ATP-binding cassette sub-family B member 5
Details
- Name
- ATP-binding cassette sub-family B member 5
- Synonyms
- ABCB5 P-gp
- P-glycoprotein ABCB5
- Gene Name
- ABCB5
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0037199|ATP-binding cassette sub-family B member 5 MENSERAEEMQENYQRNGTAEEQPKLRKEAVGSIEIFRFADGLDITLMILGILASLVNGA CLPLMPLVLGEMSDNLISGCLVQTNTTNYQNCTQSQEKLNEDMTLLTLYYVGIGVAALIF GYIQISLWIITAARQTKRIRKQFFHSVLAQDIGWFDSCDIGELNTRMTDDIDKISDGIGD KIALLFQNMSTFSIGLAVGLVKGWKLTLVTLSTSPLIMASAAACSRMVISLTSKELSAYS KAGAVAEEVLSSIRTVIAFRAQEKELQRYTQNLKDAKDFGIKRTIASKVSLGAVYFFMNG TYGLAFWYGTSLILNGEPGYTIGTVLAVFFSVIHSSYCIGAAVPHFETFAIARGAAFHIF QVIDKKPSIDNFSTAGYKPESIEGTVEFKNVSFNYPSRPSIKILKGLNLRIKSGETVALV GLNGSGKSTVVQLLQRLYDPDDGFIMVDENDIRALNVRHYRDHIGVVSQEPVLFGTTISN NIKYGRDDVTDEEMERAAREANAYDFIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALV RNPKILILDEATSALDSESKSAVQAALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGML AEKGAHAELMAKRGLYYSLVMSQDIKKADEQMESMTYSTERKTNSLPLHSVKSIKSDFID KAEESTQSKEISLPEVSLLKILKLNKPEWPFVVLGTLASVLNGTVHPVFSIIFAKIITMF GNNDKTTLKHDAEIYSMIFVILGVICFVSYFMQGLFYGRAGEILTMRLRHLAFKAMLYQD IAWFDEKENSTGGLTTILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFL ILSIAPVLAVTGMIETAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFEQMY EEMLQTQHRNTSKKAQIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAGRMTPEGMFIVFTA IAYGAMAIGETLVLAPEYSKAKSGAAHLFALLEKKPNIDSRSQEGKKPDTCEGNLEFREV SFFYPCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVD AKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEG LPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDK ARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLVNAQSVQ
- Number of residues
- 1257
- Molecular Weight
- 138639.48
- Theoretical pI
- 8.41
- GO Classification
- FunctionsATP binding / ATPase activity, coupled to transmembrane movement of substances / efflux transmembrane transporter activityProcessesantigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent / antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent / antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent / cell differentiation / compound eye corneal lens development / positive regulation of antigen processing and presentation of peptide antigen via MHC class I / regulation of membrane potential / transmembrane transportComponentsintegral component of plasma membrane / plasma membrane
- General Function
- Efflux transmembrane transporter activity
- Specific Function
- Drug efflux transporter present in a number of stem cells that acts as a regulator of cellular differentiation. Able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Specifically present in limbal stem cells, where it plays a key role in corneal development and repair.
- Pfam Domain Function
- Transmembrane Regions
- 49-69 110-130 181-201 203-223 294-314 322-342 693-713 737-757 827-847 917-937 954-974
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0011699|ATP-binding cassette sub-family B member 5 (ABCB5) ATGGAAAATTCAGAAAGAGCTGAAGAAATGCAAGAAAATTATCAGAGAAATGGAACTGCA GAAGAACAGCCAAAACTGAGAAAGGAAGCAGTTGGATCTATTGAGATATTCCGCTTTGCT GATGGACTGGACATCACACTCATGATCCTGGGTATACTGGCATCACTGGTCAATGGAGCC TGCCTTCCTTTAATGCCACTGGTTTTAGGAGAAATGAGTGATAACCTTATTAGTGGATGT CTAGTCCAAACTAACACAACAAATTATCAGAACTGTACTCAGTCTCAAGAGAAGCTGAAT GAAGATATGACTCTGTTGACCCTGTATTATGTTGGAATAGGTGTTGCTGCCTTGATTTTT GGTTACATACAGATTTCCTTGTGGATTATAACTGCAGCACGACAGACCAAGAGGATTCGA AAACAGTTTTTTCATTCAGTTTTGGCACAGGACATCGGCTGGTTTGATAGCTGTGACATC GGTGAACTTAACACTCGCATGACAGATGACATTGACAAAATCAGTGATGGTATTGGAGAT AAGATTGCTCTGTTGTTTCAAAACATGTCTACTTTTTCGATTGGCCTGGCAGTTGGTTTG GTGAAGGGCTGGAAACTCACCCTAGTGACTCTATCCACGTCTCCTCTTATAATGGCTTCA GCGGCAGCATGTTCTAGGATGGTCATCTCATTGACCAGTAAGGAATTAAGTGCCTATTCC AAAGCTGGGGCTGTGGCAGAAGAAGTCTTGTCATCAATCCGAACAGTCATAGCCTTTAGG GCCCAGGAGAAAGAACTTCAAAGGTATACACAGAATCTCAAAGATGCAAAGGATTTTGGC ATAAAAAGGACTATAGCTTCAAAAGTGTCTCTTGGTGCTGTGTACTTCTTTATGAATGGA ACCTATGGACTTGCTTTTTGGTATGGAACCTCCTTGATTCTTAATGGAGAACCTGGATAT ACCATCGGGACTGTTCTTGCTGTTTTCTTTAGTGTAATCCATAGCAGTTATTGCATTGGA GCAGCAGTCCCTCACTTTGAAACCTTCGCAATAGCCCGAGGAGCTGCCTTTCATATTTTC CAGGTTATTGATAAGAAACCCAGTATAGATAACTTTTCCACAGCTGGATATAAACCTGAA TCCATAGAAGGAACTGTGGAATTTAAAAATGTTTCTTTCAATTATCCATCAAGACCATCT ATCAAGATTCTGAAAGGTCTGAATCTCAGAATTAAGTCTGGAGAGACAGTCGCCTTGGTC GGTCTCAATGGCAGTGGGAAGAGTACGGTAGTCCAGCTTCTGCAGAGGTTATATGATCCG GATGATGGCTTTATCATGGTGGATGAGAATGACATCAGAGCTTTAAATGTGCGGCATTAT CGAGACCATATTGGAGTGGTTAGTCAAGAGCCTGTTTTGTTCGGGACCACCATCAGTAAC AATATCAAGTATGGACGAGATGATGTGACTGATGAAGAGATGGAGAGAGCAGCAAGGGAA GCAAATGCGTATGATTTTATCATGGAGTTTCCTAATAAATTTAATACATTGGTAGGGGAA AAAGGAGCTCAAATGAGTGGAGGGCAGAAACAGAGGATCGCAATTGCTCGTGCCTTAGTT CGAAACCCCAAGATTCTGATTTTAGATGAGGCTACGTCTGCCCTGGATTCAGAAAGCAAG TCAGCTGTTCAAGCTGCACTGGAGAAGGCGAGCAAAGGTCGGACTACAATCGTGGTAGCA CACCGACTTTCTACTATTCGAAGTGCAGATTTGATTGTGACCCTAAAGGATGGAATGCTG GCGGAGAAAGGAGCACATGCTGAACTAATGGCAAAACGAGGTCTATATTATTCACTTGTG ATGTCACAGGATATTAAAAAAGCTGATGAACAGATGGAGTCAATGACATATTCTACTGAA AGAAAGACCAACTCACTTCCTCTGCACTCTGTGAAGAGCATCAAGTCAGACTTCATTGAC AAGGCTGAGGAATCCACCCAATCTAAAGAGATAAGTCTTCCTGAAGTCTCTCTATTAAAA ATTTTAAAGTTAAACAAGCCTGAATGGCCTTTTGTGGTTCTGGGGACATTGGCTTCTGTT CTAAATGGAACTGTTCATCCAGTATTTTCCATCATCTTTGCAAAAATTATAACCATGTTT GGAAATAATGATAAAACCACATTAAAGCATGATGCAGAAATTTATTCCATGATATTCGTC ATTTTGGGTGTTATTTGCTTTGTCAGTTATTTCATGCAGGGATTATTTTACGGCAGAGCA GGGGAAATTTTAACGATGAGATTAAGACACTTGGCCTTCAAAGCCATGTTATATCAGGAT ATTGCCTGGTTTGATGAAAAGGAAAACAGCACAGGAGGCTTGACAACAATATTAGCCATA GATATAGCACAAATTCAAGGAGCAACAGGTTCCAGGATTGGCGTCTTAACACAAAATGCA ACTAACATGGGACTTTCAGTTATCATTTCCTTTATATATGGATGGGAGATGACATTCCTG ATTCTGAGTATTGCTCCAGTACTTGCCGTGACAGGAATGATTGAAACCGCAGCAATGACT GGATTTGCCAACAAAGATAAGCAAGAACTTAAGCATGCTGGAAAGATAGCAACTGAAGCT TTGGAGAATATACGTACTATAGTGTCATTAACAAGGGAAAAAGCCTTCGAGCAAATGTAT GAAGAGATGCTTCAGACTCAACACAGAAATACCTCGAAGAAAGCACAGATTATTGGAAGC TGTTATGCATTCAGCCATGCCTTTATATATTTTGCCTATGCGGCAGGGTTTCGATTTGGA GCCTATTTAATTCAAGCTGGACGAATGACCCCAGAGGGCATGTTCATAGTTTTTACTGCA ATTGCATATGGAGCTATGGCCATCGGAGAAACGCTCGTTTTGGCTCCTGAATATTCCAAA GCCAAATCGGGGGCTGCGCATCTGTTTGCCTTGTTGGAAAAGAAACCAAATATAGACAGC CGCAGTCAAGAAGGGAAAAAGCCAGACACATGTGAAGGGAATTTAGAGTTTCGAGAAGTC TCTTTCTTCTATCCATGTCGCCCAGATGTTTTCATCCTCCGTGGCTTATCCCTCAGTATT GAGCGAGGAAAGACAGTAGCATTTGTGGGGAGCAGCGGCTGTGGGAAAAGCACTTCTGTT CAACTTCTGCAGAGACTTTATGACCCCGTGCAAGGACAAGTGCTGTTTGATGGTGTGGAT GCAAAAGAATTGAATGTACAGTGGCTCCGTTCCCAAATAGCAATCGTTCCTCAAGAGCCT GTGCTCTTCAACTGCAGCATTGCTGAGAACATCGCCTATGGTGACAACAGCCGTGTGGTG CCATTAGATGAGATCAAAGAAGCCGCAAATGCAGCAAATATCCATTCTTTTATTGAAGGT CTCCCTGAGAAATACAACACACAAGTTGGACTGAAAGGAGCACAGCTTTCTGGCGGCCAG AAACAAAGACTAGCTATTGCAAGGGCTCTTCTCCAAAAACCCAAAATTTTATTGTTGGAT GAGGCCACTTCAGCCCTCGATAATGACAGTGAGAAGGTGGTTCAGCATGCCCTTGATAAA GCCAGGACGGGAAGGACATGCCTAGTGGTCACTCACAGGCTCTCTGCAATTCAGAACGCA GATTTGATAGTGGTTCTGCACAATGGAAAGATAAAGGAACAAGGAACTCATCAAGAGCTC CTGAGAAATCGAGACATATATTTTAAGTTAGTGAATGCACAGTCAGTGCAGTGA
- Chromosome Location
- 7
- Locus
- 7p15.3
- External Identifiers
Resource Link UniProtKB ID Q2M3G0 UniProtKB Entry Name ABCB5_HUMAN GenBank Gene ID AY090613 GenAtlas ID ABCB5 HGNC ID HGNC:46 - General References
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB04851 Biricodar investigational unknown Details DB09183 Dasabuvir approved no substrate Details DB11943 Delafloxacin approved, investigational no substrate Details DB11591 Bilastine approved, investigational unknown substrateinhibitor Details DB11691 Naldemedine approved, investigational no substrate Details DB12267 Brigatinib approved, investigational no substrateinhibitor Details DB11641 Vinflunine approved, investigational no substrate Details DB06263 Amrubicin investigational unknown substrate Details DB08870 Brentuximab vedotin approved, investigational unknown substrate Details DB12010 Fostamatinib approved, investigational no substrate Details DB04948 Lofexidine approved, investigational no inhibitor Details DB14067 Dofequidar experimental, investigational unknown inhibitor Details DB00254 Doxycycline approved, investigational, vet_approved unknown inducer Details DB00598 Labetalol approved unknown Details