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Identification
NameDoxycycline
Accession NumberDB00254  (APRD00597)
TypeSmall Molecule
GroupsApproved, Investigational, Vet Approved
DescriptionA synthetic tetracycline derivative with similar antimicrobial activity. Animal studies suggest that it may cause less tooth staining than other tetracyclines. It is used in some areas for the treatment of chloroquine-resistant falciparum malaria (malaria, falciparum). [PubChem]
Structure
Thumb
Synonyms
(4S,4AR,5S,5ar,6R,12as)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
5-Hydroxy-alpha-6-deoxytetracycline
6-alpha-deoxy-5-oxytetracycline
6alpha-Deoxy-5-oxytetracycline
6α-deoxy-5-oxytetracycline
Doxiciclina
Doxycyclin
Doxycycline (anhydrous)
Doxycyclinum
Jenacyclin
Supracyclin
Vibramycin
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Acticlatetablet, coated75 mg/1oralAqua Pharmaceuticals2014-07-28Not applicableUs
Acticlatetablet, coated150 mg/1oralAqua Pharmaceuticals2014-07-28Not applicableUs
Alti-doxycycline - Tab 100mgtablet100 mgoralAltimed Pharma Inc.1995-12-312001-09-05Canada
Alti-doxycycline-cap 100mgcapsule100 mgoralAltimed Pharma Inc.1995-12-312001-09-05Canada
AtridoxkitoralTOLMAR Inc.1998-09-03Not applicableUs
Atridoxgel (controlled-release)44 mgsubgingivalTolmar Inc2001-01-31Not applicableCanada
Dom-doxycyclinecapsule100 mgoralDominion Pharmacal2008-04-16Not applicableCanada
Dom-doxycyclinetablet100 mgoralDominion Pharmacal2008-04-16Not applicableCanada
Doryxtablet, delayed release200 mg/1oralMayne Pharma2015-04-13Not applicableUs
Doryxtablet, delayed release150 mg/1oralWarner Chilcott (US), LLC2011-09-21Not applicableUs
Doryxtablet, delayed release200 mg/1oralWarner Chilcott (US), LLC2013-07-01Not applicableUs
Doryxtablet, delayed release50 mg/1oralMayne Pharma2015-05-26Not applicableUs
Doryx 100mg Capcapsule (sustained-release)100 mgoralParke Davis Division, Warner Lambert Canada Inc.1991-12-311998-09-14Canada
Doxycin Cap 100mgcapsule100 mgoralLaboratoire Riva Inc1989-12-31Not applicableCanada
Doxycin Tab 100mgtablet100 mgoralLaboratoire Riva Inc1989-12-31Not applicableCanada
Doxycyclinecapsule40 mg/1oralPrasco Laboratories2015-04-01Not applicableUs
Doxycyclinecapsule40 mg/1oralOwen Laboratories, Inc.2010-05-14Not applicableUs
Doxycyclinecapsule100 mg/1oralGreenstone LLC2015-05-01Not applicableUs
Doxycycline Capsulescapsule100 mgoralSanis Health Inc2010-06-15Not applicableCanada
Doxycycline Hyclatetablet, delayed release75 mg/1oralMayne Pharma Inc.2013-07-08Not applicableUs
Doxycycline Hyclatetablet, delayed release100 mg/1oralMayne Pharma Inc.2013-07-08Not applicableUs
Doxycycline Hyclatetablet, delayed release200 mg/1oralMayne Pharma Inc.2016-02-01Not applicableUs
Doxycycline Hyclatetablet, delayed release150 mg/1oralMayne Pharma Inc.2013-07-08Not applicableUs
Doxycycline Monohydratecapsule75 mg/1oralActavis Pharma, Inc.2011-02-07Not applicableUs
Doxycycline Monohydratecapsule100 mg/1oralPhysicians Total Care, Inc.2010-10-22Not applicableUs
Doxycycline Monohydratecapsule50 mg/1oralActavis Pharma, Inc.2005-02-07Not applicableUs
Doxycycline Monohydratecapsule100 mg/1oralPd Rx Pharmaceuticals, Inc.2005-02-07Not applicableUs
Doxycycline Monohydratecapsule100 mg/1oralActavis Pharma, Inc.2005-02-07Not applicableUs
Doxycycline Monohydratecapsule100 mg/1oralbryant ranch prepack2005-02-07Not applicableUs
Doxycycline Tabletstablet100 mgoralSanis Health Inc2010-06-15Not applicableCanada
Doxycycline-100 Cap 100mg USPcapsule100 mgoralPro Doc Limitee1987-12-312010-07-13Canada
Doxytab 100mgtablet100 mgoralPro Doc Limitee1990-12-31Not applicableCanada
Monodoxcapsule75 mg/1oralAqua Pharmaceuticals, LLC2007-01-31Not applicableUs
Monodoxcapsule100 mg/1oralAqua Pharmaceuticals, LLC1989-12-29Not applicableUs
Monodoxcapsule50 mg/1oralAqua Pharmaceuticals, LLC1992-02-10Not applicableUs
Ntp-doxycycline Capsulescapsule100 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Ntp-doxycycline Tabletstablet100 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Nu-doxycycline Cap 100mgcapsule100 mgoralNu Pharm Inc1993-12-312012-09-04Canada
Nu-doxycycline Tab 100mgtablet100 mgoralNu Pharm Inc1993-12-312012-09-04Canada
Oraceacapsule40 mg/1oralGalderma Laboratories, L.P.2010-05-14Not applicableUs
Penta-doxycycline Tabletstablet100 mgoralPentapharm Ltd.Not applicableNot applicableCanada
Periostatcapsule20 mgoralPendopharm Division Of De Pharmascience Inc2003-09-03Not applicableCanada
PHL-doxycyclinetablet100 mgoralPharmel Inc2007-07-27Not applicableCanada
PHL-doxycyclinecapsule100 mgoralPharmel Inc2007-07-27Not applicableCanada
PMS-doxycyclinetablet100 mgoralPharmascience Inc2007-04-12Not applicableCanada
PMS-doxycyclinecapsule100 mgoralPharmascience Inc2007-04-12Not applicableCanada
Ratio-doxycyclinetablet100 mgoralRatiopharm Inc Division Of Teva Canada Limited1994-12-312008-08-01Canada
Ratio-doxycyclinecapsule100 mgoralRatiopharm Inc Division Of Teva Canada Limited1994-12-312008-08-01Canada
Rho-doxycin - Cap 100mgcapsule100 mgoralRhodiapharm Inc1995-12-311996-09-09Canada
Rho-doxycin Tabs - 100mgtablet100 mgoralRhodiapharm Inc1995-12-311996-09-09Canada
Rho-doxycycline - Cap 100mgcapsule100 mgoralRhodiapharm Inc1996-02-021998-08-05Canada
Rho-doxycycline - Tab 100mgtablet100 mgoralRhodiapharm Inc1996-12-311998-08-05Canada
Teva-doxycyclinetablet100 mgoralTeva Canada Limited1995-12-31Not applicableCanada
Teva-doxycyclinecapsule100 mgoralTeva Canada Limited1989-12-31Not applicableCanada
Vibra-tabstablet100 mgoralPfizer Canada Inc1986-12-312014-04-04Canada
Vibramycin Calciumsyrup50 mg/5mLoralPfizer Laboratories Div Pfizer Inc1974-09-23Not applicableUs
Vibramycin Cap 100mgcapsule100 mgoralPfizer Canada Inc1969-12-312016-04-04Canada
Vibramycin Hyclatecapsule100 mg/1oralPfizer Laboratories Div Pfizer Inc1967-12-05Not applicableUs
Vibramycin Injpowder100 mgintravenousPfizer Canada Inc1997-07-252000-07-26Canada
Vibramycin Monohydratepowder, for suspension25 mg/5mLoralPfizer Laboratories Div Pfizer Inc1967-12-06Not applicableUs
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Adoxacapsule150 mg/1oralPharma Derm A Division Of Fougera Pharmaceuticals Inc.2011-06-01Not applicableUs
Alodoxtablet20 mg/1oralO Cu Soft Inc.2008-10-01Not applicableUs
Apo-doxy Cap 100mgcapsule100 mgoralApotex Inc1987-12-31Not applicableCanada
Apo-doxy Tabs 100mgtablet100 mgoralApotex Inc1990-12-31Not applicableCanada
Direct Rxtablet100 mg/1oralDIRECT RX2015-01-01Not applicableUs
Doxy 100injection, powder, lyophilized, for solution100 mg/100mgintravenousGeneral Injectables & Vaccines, Inc2012-02-22Not applicableUs
Doxy 100injection, powder, lyophilized, for solution100 mg/10mLintravenousFresenius Kabi USA, LLC2000-10-17Not applicableUs
Doxycyclate Hyclatecapsule50 mg/1oralGolden State Medical Supply, Inc.2002-12-092016-02-22Us
Doxycyclate Hyclatecapsule100 mg/1oralGolden State Medical Supply, Inc.2002-12-092016-02-22Us
Doxycyclate Hyclatecapsule100 mg/1oralWest Ward Pharmaceuticals Corp1990-09-01Not applicableUs
Doxycyclate Hyclatecapsule100 mg/1oralLiberty Pharmaceuticals, Inc.1990-09-01Not applicableUs
Doxycyclinecapsule50 mg/1oralLupin Pharmaceuticals, Inc.2014-04-14Not applicableUs
Doxycyclinetablet100 mg/1oralKAISER FOUNDATION HOSPITALS2014-04-28Not applicableUs
Doxycyclinetablet150 mg/1oralHeritage Pharmaceuticals Inc.2012-01-05Not applicableUs
Doxycyclinetablet, coated100 mg/1oralAidarex Pharmaceuticals LLC2003-07-02Not applicableUs
Doxycyclinecapsule50 mg/1oralPd Rx Pharmaceuticals, Inc.2015-07-08Not applicableUs
Doxycyclinetablet50 mg/1oralLake Erie Medical DBA Quality Care Products LLC2012-01-05Not applicableUs
Doxycyclinecapsule75 mg/1oralRanbaxy Pharmaceuticals Inc.2000-12-26Not applicableUs
Doxycyclinecapsule50 mg/1oralCadila Healthcare Limited2016-03-14Not applicableUs
Doxycyclineinjection, powder, lyophilized, for solution100 mg/10mLintravenousPfizer Laboratories Div Pfizer Inc2012-08-21Not applicableUs
Doxycyclinetablet75 mg/1oralPar Pharmaceutical Inc2000-12-15Not applicableUs
Doxycyclinetablet, film coated150 mg/1oralLannett Company, Inc.2008-08-25Not applicableUs
Doxycyclinetablet, film coated50 mg/1oralLannett Company, Inc.2005-12-08Not applicableUs
Doxycyclinetablet, coated100 mg/1oralREMEDYREPACK INC.2013-05-10Not applicableUs
Doxycyclinetablet, film coated100 mg/1oralElorac, Inc.2005-12-08Not applicableUs
Doxycyclinecapsule100 mg/1oralCardinal Health2000-12-01Not applicableUs
Doxycyclinetablet, coated100 mg/1oralMedsource Pharmaceuticals2003-07-02Not applicableUs
Doxycyclinetablet, film coated75 mg/1oralRanbaxy Pharmaceuticals Inc.2006-10-05Not applicableUs
Doxycyclinetablet, coated100 mg/1oralKeltman Pharmaceuticals Inc.2011-01-10Not applicableUs
Doxycyclinetablet, coated100 mg/1oralWest Ward Pharmaceuticals Corp2003-07-02Not applicableUs
Doxycyclinetablet, film coated100 mg/1oralMylan Pharmaceuticals Inc.2006-11-17Not applicableUs
Doxycyclinecapsule50 mg/1oralPar Pharmaceutical Inc.2000-12-01Not applicableUs
Doxycyclinetablet50 mg/1oralHeritage Pharmaceuticals Inc.2012-01-05Not applicableUs
Doxycyclinecapsule50 mg/1oralNovel Laboratories, Inc.2015-05-28Not applicableUs
Doxycyclinecapsule75 mg/1oralGAVIS Pharmaceuticals, LLC2015-07-08Not applicableUs
Doxycyclinetablet, coated100 mg/1oralA S Medication Solutions Llc2003-07-02Not applicableUs
Doxycyclinetablet, coated100 mg/1oralBlenheim Pharmacal, Inc.2012-05-09Not applicableUs
Doxycyclinetablet, coated100 mg/1oralAmerican Health Packaging2013-03-22Not applicableUs
Doxycyclinecapsule75 mg/1oralLupin Pharmaceuticals, Inc.2014-04-14Not applicableUs
Doxycyclinecapsule100 mg/1oralREMEDYREPACK INC.2016-04-08Not applicableUs
Doxycyclinetablet, coated100 mg/1oralLiberty Pharmaceuticals, Inc.2003-07-02Not applicableUs
Doxycyclinecapsule150 mg/1oralMylan Pharmaceuticals Inc.2012-06-12Not applicableUs
Doxycyclinetablet100 mg/1oralPar Pharmaceutical Inc2000-12-15Not applicableUs
Doxycyclineinjection, powder, lyophilized, for solution100 mg/100mgintravenousGeneral Injectables & Vaccines, Inc2010-08-01Not applicableUs
Doxycyclinecapsule100 mg/1oralPd Rx Pharmaceuticals, Inc.2015-07-08Not applicableUs
Doxycyclinetablet100 mg/1oralLake Erie Medical DBA Quality Care Products LLC2012-01-05Not applicableUs
Doxycyclinecapsule100 mg/1oralRanbaxy Pharmaceuticals Inc.2000-12-26Not applicableUs
Doxycyclineinjection, powder, lyophilized, for solution100 mg/10mLintravenousMylan Institutional LLC2012-08-21Not applicableUs
Doxycyclinecapsule75 mg/1oralCadila Healthcare Limited2016-03-14Not applicableUs
Doxycyclinecapsule75 mg/1oralZydus Pharmaceuticals (USA) Inc.2016-03-14Not applicableUs
Doxycyclinecapsule100 mg/1oralREMEDYREPACK INC.2013-05-15Not applicableUs
Doxycyclinetablet, coated100 mg/1oralBlu Pharmaceuticals, LLC2010-05-01Not applicableUs
Doxycyclinetablet, coated100 mg/1oralCardinal Health2013-03-22Not applicableUs
Doxycyclinetablet, film coated100 mg/1oralRanbaxy Pharmaceuticals Inc.2006-10-05Not applicableUs
Doxycyclinepowder, for suspension25 mg/5mLoralHarris Pharmaceutical, Inc2008-07-16Not applicableUs
Doxycyclinetablet, film coated150 mg/1oralMylan Pharmaceuticals Inc.2007-06-08Not applicableUs
Doxycyclinecapsule100 mg/1oralPar Pharmaceutical Inc.2000-12-01Not applicableUs
Doxycyclinetablet75 mg/1oralHeritage Pharmaceuticals Inc.2012-01-05Not applicableUs
Doxycyclinecapsule75 mg/1oralNovel Laboratories, Inc.2015-05-28Not applicableUs
Doxycyclinecapsule100 mg/1oralGAVIS Pharmaceuticals, LLC2015-07-08Not applicableUs
Doxycyclinetablet, coated100 mg/1oralA S Medication Solutions Llc2003-07-02Not applicableUs
Doxycyclinetablet, coated100 mg/1oralGolden State Medical Supply, Inc.2003-07-022016-02-22Us
Doxycyclinecapsule100 mg/1oralProficient Rx LP2000-12-01Not applicableUs
Doxycyclinecapsule100 mg/1oralLupin Pharmaceuticals, Inc.2014-04-14Not applicableUs
Doxycyclinepowder, for suspension25 mg/5mLoralCIPLA USA, Inc2008-07-16Not applicableUs
Doxycyclinecapsule100 mg/1oralProficient Rx LP2014-04-14Not applicableUs
Doxycyclinetablet, film coated50 mg/1oralMylan Pharmaceuticals Inc.2006-11-17Not applicableUs
Doxycyclinetablet150 mg/1oralPar Pharmaceutical Inc2000-12-15Not applicableUs
Doxycyclinetablet, film coated50 mg/1oralDIRECT RX2015-01-01Not applicableUs
Doxycyclinecapsule100 mg/1oralCadila Healthcare Limited2016-03-14Not applicableUs
Doxycyclinetablet, coated100 mg/1oralLegacy Pharmaceutical Packaging2010-05-01Not applicableUs
Doxycyclinecapsule100 mg/1oralZydus Pharmaceuticals (USA) Inc.2016-03-14Not applicableUs
Doxycyclinetablet, film coated100 mg/1oralLannett Company, Inc.2005-12-08Not applicableUs
Doxycyclinetablet, film coated150 mg/1oralRanbaxy Pharmaceuticals Inc.2006-10-05Not applicableUs
Doxycyclinetablet, coated100 mg/1oralCardinal Health2003-07-02Not applicableUs
Doxycyclinetablet, film coated100 mg/1oralKAISER FOUNDATION HOSPITALS2013-03-14Not applicableUs
Doxycyclinetablet, coated100 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2011-12-07Not applicableUs
Doxycyclinetablet100 mg/1oralHeritage Pharmaceuticals Inc.2012-01-05Not applicableUs
Doxycyclinecapsule100 mg/1oralNovel Laboratories, Inc.2015-05-28Not applicableUs
Doxycyclinetablet, coated100 mg/1oralCardinal Health2004-08-03Not applicableUs
Doxycyclinetablet, film coated50 mg/1oralRanbaxy Pharmaceuticals Inc.2006-10-05Not applicableUs
Doxycyclinefor suspension25 mg/5mLoralLupin Pharmaceuticals, Inc.2013-06-04Not applicableUs
Doxycyclinecapsule100 mg/1oralLake Erie Medical DBA Quality Care Products LLC2000-12-01Not applicableUs
Doxycyclinecapsule150 mg/1oralImpax Generics2011-02-17Not applicableUs
Doxycyclinetablet, film coated75 mg/1oralMylan Pharmaceuticals Inc.2006-11-17Not applicableUs
Doxycyclinecapsule150 mg/1oralPar Pharmaceutical Inc.2011-06-01Not applicableUs
Doxycyclinetablet, coated100 mg/1oralRebel Distributors Corp.2003-07-02Not applicableUs
Doxycyclinecapsule50 mg/1oralGAVIS Pharmaceuticals, LLC2015-07-08Not applicableUs
Doxycyclinetablet, coated100 mg/1oralDIRECT RX2015-12-17Not applicableUs
Doxycyclinecapsule100 mg/1oralAmerican Health Packaging2014-06-02Not applicableUs
Doxycyclinetablet, coated100 mg/1oralSt Marys Medical Park Pharmacy2003-07-02Not applicableUs
Doxycyclinecapsule50 mg/1oralRanbaxy Pharmaceuticals Inc.2000-12-26Not applicableUs
Doxycyclinecapsule50 mg/1oralZydus Pharmaceuticals (USA) Inc.2016-03-14Not applicableUs
Doxycyclinetablet, film coated75 mg/1oralLannett Company, Inc.2008-08-25Not applicableUs
Doxycyclinecapsule100 mg/1oralREMEDYREPACK INC.2013-11-18Not applicableUs
Doxycyclinetablet, coated100 mg/1oralPd Rx Pharmaceuticals, Inc.2003-07-02Not applicableUs
Doxycyclinetablet50 mg/1oralPar Pharmaceutical Inc2000-12-15Not applicableUs
Doxycycline Hyclatetablet, film coated100 mg/1oralMutual Pharmaceutical Company, Inc.1986-07-10Not applicableUs
Doxycycline Hyclatecapsule50 mg/1oralRebel Distributors Corp1984-11-07Not applicableUs
Doxycycline Hyclatecapsule50 mg/1oralPhysicians Total Care, Inc.1994-08-01Not applicableUs
Doxycycline Hyclatecapsule100 mg/1oralChartwell RX LLC1984-09-11Not applicableUs
Doxycycline Hyclatecapsule50 mg/1oralDispensing Solutions, Inc.1986-07-10Not applicableUs
Doxycycline Hyclatecapsule100 mg/1oralCipla USA, Inc.1984-09-11Not applicableUs
Doxycycline Hyclatecapsule, gelatin coated50 mg/1oralWest Ward Pharmaceuticals Corp1984-11-07Not applicableUs
Doxycycline Hyclatetablet, film coated100 mg/1oralA S Medication Solutions1986-07-10Not applicableUs
Doxycycline Hyclatecapsule100 mg/1oralLiberty Pharmaceuticals, Inc.1984-05-07Not applicableUs
Doxycycline Hyclatecapsule100 mg/1oralLake Erie Medical DBA Quality Care Products LLC2012-04-16Not applicableUs
Doxycycline Hyclatecapsule100 mg/1oralBlenheim Pharmacal, Inc.2011-11-15Not applicableUs
Doxycycline Hyclatetablet100 mg/1oralNorthwind Pharmaceuticals2014-09-15Not applicableUs
Doxycycline Hyclatecapsule, gelatin coated100 mg/1oralA S Medication Solutions Llc1984-05-07Not applicableUs
Doxycycline Hyclatecapsule100 mg/1oralSTAT Rx USA LLC1984-05-07Not applicableUs
Doxycycline Hyclatecapsule50 mg/1oralA S Medication Solutions Llc1986-07-10Not applicableUs
Doxycycline Hyclatecapsule, gelatin coated100 mg/1oralVersa Pharm Incorporated1998-04-01Not applicableUs
Doxycycline Hyclatecapsule100 mg/1oralHarris Pharmaceutical, Inc1984-09-11Not applicableUs
Doxycycline Hyclatecapsule100 mg/1oralPreferred Pharmaceuticals, Inc.2011-06-09Not applicableUs
Doxycycline Hyclatetablet, delayed release100 mg/1oralMylan Pharmaceuticals Inc.2010-12-30Not applicableUs
Doxycycline Hyclatecapsule100 mg/1oralMylan Pharmaceuticals Inc.1982-03-29Not applicableUs
Doxycycline Hyclatetablet, film coated100 mg/1oralA S Medication Solutions Llc1986-07-10Not applicableUs
Doxycycline Hyclatetablet, film coated100 mg/1oralHHS/Program Support Center/Supply Service Center2011-06-17Not applicableUs
Doxycycline Hyclatecapsule100 mg/1oralREMEDYREPACK INC.2012-01-12Not applicableUs
Doxycycline Hyclatecapsule100 mg/1oralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
Doxycycline Hyclatetablet100 mg/1oralDAVA Pharmaceuticals, Inc.1984-09-11Not applicableUs
Doxycycline Hyclatecapsule100 mg/1oralMHC Pharma, LLC1984-09-11Not applicableUs
Doxycycline Hyclatetablet, film coated100 mg/1oralDepartment Of State Health Services, Pharmacy Branch1986-07-10Not applicableUs
Doxycycline Hyclatecapsule100 mg/1oralCardinal Health1982-01-01Not applicableUs
Doxycycline Hyclatecapsule, gelatin coated50 mg/1oralMajor Pharmaceuticals1984-11-01Not applicableUs
Doxycycline Hyclatecapsule100 mg/1oralAv Pak2014-06-05Not applicableUs
Doxycycline Hyclatetablet, film coated100 mg/1oralAphena Pharma Solutions New Jersey, Llc1986-07-10Not applicableUs
Doxycycline Hyclatetablet, film coated100 mg/1oralCitron Pharma LLC1984-09-11Not applicableUs
Doxycycline Hyclatetablet, film coated20 mg/1oralCore Pharma, Llc2005-12-122016-03-15Us
Doxycycline Hyclatecapsule50 mg/1oralChartwell Governmental and Specialty RX LLC1984-09-11Not applicableUs
Doxycycline Hyclatecapsule100 mg/1oralREMEDYREPACK INC.2013-02-27Not applicableUs
Doxycycline Hyclatetablet, film coated20 mg/1oralMutual Pharmaceutical Company, Inc.2005-05-13Not applicableUs
Doxycycline Hyclatetablet, film coated100 mg/1oralAv Kare, Inc.2013-06-06Not applicableUs
Doxycycline Hyclatetablet, film coated20 mg/1oralPhysicians Total Care, Inc.2005-04-20Not applicableUs
Doxycycline Hyclatecapsule100 mg/1oralContract Pharmacy Services Pa2010-03-10Not applicableUs
Doxycycline Hyclatetablet, film coated100 mg/1oralCipla USA, Inc.1984-09-11Not applicableUs
Doxycycline Hyclatecapsule, gelatin coated100 mg/1oralWest Ward Pharmaceuticals Corp1984-05-07Not applicableUs
Doxycycline Hyclatetablet, delayed release75 mg/1oralActavis Pharma, Inc.2013-10-28Not applicableUs
Doxycycline Hyclatetablet, delayed release75 mg/1oralGlobal Pharmaceuticals, Division of Impax Laboratories, Inc.2011-04-11Not applicableUs
Doxycycline Hyclatecapsule100 mg/1oralActavis Pharma, Inc.1977-02-14Not applicableUs
Doxycycline Hyclatecapsule100 mg/1oralA S Medication Solutions Llc1986-07-10Not applicableUs
Doxycycline Hyclatecapsule50 mg/1oralSTAT Rx USA LLC1984-11-07Not applicableUs
Doxycycline Hyclatecapsule100 mg/1oralAidarex Pharmaceuticals LLC1984-05-07Not applicableUs
Doxycycline Hyclatecapsule100 mg/1oralA S Medication Solutions Llc1977-02-14Not applicableUs
Doxycycline Hyclatecapsule100 mg/1oralDIRECT RX2014-01-01Not applicableUs
Doxycycline Hyclatetablet, film coated100 mg/1oralPreferred Pharmaceuticals, Inc.2015-04-21Not applicableUs
Doxycycline Hyclatetablet, film coated100 mg/1oralMHC Pharma, LLC1984-09-11Not applicableUs
Doxycycline Hyclatetablet100 mg/1oralMylan Pharmaceuticals Inc.1983-02-15Not applicableUs
Doxycycline Hyclatetablet, film coated20 mg/1oralLannett Company, Inc.2005-11-10Not applicableUs
Doxycycline Hyclatecapsule, gelatin coated50 mg/1oralA S Medication Solutions Llc1984-11-07Not applicableUs
Doxycycline Hyclatetablet, coated100 mg/1oralHHS/Program Support Center/Supply Service Center2003-07-02Not applicableUs
Doxycycline Hyclatecapsule100 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Doxycycline Hyclatetablet, film coated100 mg/1oralApothecary Shop Wholesale Inc.2011-07-01Not applicableUs
Doxycycline Hyclatetablet, film coated100 mg/1oralSafecor Health, LLC1986-07-10Not applicableUs
Doxycycline Hyclatecapsule, gelatin coated100 mg/1oralGolden State Medical Supply, Inc.2015-03-16Not applicableUs
Doxycycline Hyclatetablet, film coated100 mg/1oralLegacy Pharmaceutical Packaging2011-02-09Not applicableUs
Doxycycline Hyclatecapsule50 mg/1oralAmerican Health Packaging2015-03-31Not applicableUs
Doxycycline Hyclatecapsule100 mg/1oralChartwell Governmental and Specialty RX LLC1984-09-11Not applicableUs
Doxycycline Hyclatetablet100 mg/1oralCardinal Health1983-02-02Not applicableUs
Doxycycline Hyclatecapsule100 mg/1oralMajor Pharmaceuticals2008-08-05Not applicableUs
Doxycycline Hyclatetablet, film coated100 mg/1oralAv Pak2014-06-05Not applicableUs
Doxycycline Hyclatecapsule50 mg/1oralMutual Pharmaceutical Company, Inc.1986-07-10Not applicableUs
Doxycycline Hyclatecapsule100 mg/1oralPhysicians Total Care, Inc.1993-06-11Not applicableUs
Doxycycline Hyclatecapsule100 mg/1oralClinical Solutions Wholesale1984-05-07Not applicableUs
Doxycycline Hyclatetablet, film coated100 mg/1oralChartwell RX LLC1984-09-11Not applicableUs
Doxycycline Hyclatecapsule100 mg/1oralTYA Pharmaceuticals1977-02-14Not applicableUs
Doxycycline Hyclatetablet, delayed release100 mg/1oralActavis Pharma, Inc.2013-10-28Not applicableUs
Doxycycline Hyclatecapsule100 mg/1oralC.O. Truxton, Inc.2013-01-14Not applicableUs
Doxycycline Hyclatecapsule100 mg/1oralBlenheim Pharmacal, Inc.2013-01-14Not applicableUs
Doxycycline Hyclatecapsule100 mg/1oralREMEDYREPACK INC.2012-10-01Not applicableUs
Doxycycline Hyclatecapsule100 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Doxycycline Hyclatecapsule50 mg/1oralAv Kare, Inc.2013-07-23Not applicableUs
Doxycycline Hyclatecapsule50 mg/1oralDAVA Pharmaceuticals, Inc.1984-09-11Not applicableUs
Doxycycline Hyclatecapsule, gelatin coated50 mg/1oralPd Rx Pharmaceuticals, Inc.1984-11-07Not applicableUs
Doxycycline Hyclatetablet, delayed release100 mg/1oralGlobal Pharmaceuticals, Division of Impax Laboratories, Inc.2011-04-11Not applicableUs
Doxycycline Hyclatecapsule50 mg/1oralActavis Pharma, Inc.1982-10-13Not applicableUs
Doxycycline Hyclatecapsule100 mg/1oralA S Medication Solutions Llc1986-07-10Not applicableUs
Doxycycline Hyclatecapsule100 mg/1oralRebel Distributors Corp1984-11-07Not applicableUs
Doxycycline Hyclatecapsule100 mg/1oralH.J. Harkins Company, Inc.1984-11-07Not applicableUs
Doxycycline Hyclatetablet, film coated20 mg/1oralAidarex Pharmaceuticals LLC2005-11-10Not applicableUs
Doxycycline Hyclatetablet100 mg/1oralA S Medication Solutions Llc1983-02-02Not applicableUs
Doxycycline Hyclatetablet, film coated100 mg/1oralAphena Pharma Solutions Tennessee, Llc1986-07-10Not applicableUs
Doxycycline Hyclatecapsule50 mg/1oralCitron Pharma LLC1984-09-11Not applicableUs
Doxycycline Hyclatetablet20 mg/1oralLarken Laboratories, Inc.2010-11-15Not applicableUs
Doxycycline Hyclatetablet, film coated100 mg/1oralPreferred Pharmaceuticals Inc.2015-08-19Not applicableUs
Doxycycline Hyclatecapsule100 mg/1oralLife Line Home Care Services, Inc.2012-02-08Not applicableUs
Doxycycline Hyclatetablet, film coated100 mg/1oralHarris Pharmaceutical, Inc1984-09-11Not applicableUs
Doxycycline Hyclatecapsule50 mg/1oralMHC Pharma, LLC1984-09-11Not applicableUs
Doxycycline Hyclatetablet, delayed release150 mg/1oralMylan Pharmaceuticals Inc.2012-04-30Not applicableUs
Doxycycline Hyclatecapsule50 mg/1oralA S Medication Solutions Llc1986-07-10Not applicableUs
Doxycycline Hyclatetablet, film coated100 mg/1oralHHS/Program Support Center/Supply Service Center2011-06-17Not applicableUs
Doxycycline Hyclatecapsule100 mg/1oralREMEDYREPACK INC.2013-05-20Not applicableUs
Doxycycline Hyclatetablet100 mg/1oralBlu Pharmaceuticals, LLC2013-11-25Not applicableUs
Doxycycline Hyclatecapsule100 mg/1oralState of Florida DOH Central Pharmacy2014-11-01Not applicableUs
Doxycycline Hyclatecapsule100 mg/1oralPd Rx Pharmaceuticals, Inc.1984-05-07Not applicableUs
Doxycycline Hyclatecapsule100 mg/1oralPd Rx Pharmaceuticals, Inc.1984-05-07Not applicableUs
Doxycycline Hyclatecapsule100 mg/1oralREMEDYREPACK INC.2012-03-29Not applicableUs
Doxycycline Hyclatecapsule100 mg/1oralAmerican Health Packaging2015-06-01Not applicableUs
Doxycycline Hyclatecapsule50 mg/1oralChartwell RX LLC1984-09-11Not applicableUs
Doxycycline Hyclatetablet, film coated100 mg/1oralMed Vantx, Inc.1984-09-11Not applicableUs
Doxycycline Hyclatecapsule100 mg/1oralCarilion Materials Management1984-05-07Not applicableUs
Doxycycline Hyclatecapsule50 mg/1oralCipla USA, Inc.1984-09-11Not applicableUs
Doxycycline Hyclatetablet100 mg/1oralAvera Mc Kennan Hospital2015-03-09Not applicableUs
Doxycycline Hyclatetablet100 mg/1oralUnit Dose Services1983-02-02Not applicableUs
Doxycycline Hyclatecapsule100 mg/1oralMutual Pharmaceutical Company, Inc.1986-07-10Not applicableUs
Doxycycline Hyclatetablet100 mg/1oralPhysicians Total Care, Inc.1994-03-24Not applicableUs
Doxycycline Hyclatecapsule50 mg/1oralMylan Pharmaceuticals Inc.1982-03-29Not applicableUs
Doxycycline Hyclatetablet100 mg/1oralC.O. Truxton, Inc.2013-11-25Not applicableUs
Doxycycline Hyclatetablet, film coated100 mg/1oralA S Medication Solutions Llc1986-07-10Not applicableUs
Doxycycline Hyclatecapsule100 mg/1oralBlenheim Pharmacal, Inc.2009-12-22Not applicableUs
Doxycycline Hyclatecapsule100 mg/1oralREMEDYREPACK INC.2013-02-09Not applicableUs
Doxycycline Hyclatecapsule100 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Doxycycline Hyclatecapsule100 mg/1oralAv Kare, Inc.2013-07-23Not applicableUs
Doxycycline Hyclatecapsule100 mg/1oralMedsource Pharmaceuticals1986-07-10Not applicableUs
Doxycycline Hyclatetablet100 mg/1oralGolden State Medical Supply, Inc.2014-02-12Not applicableUs
Doxycycline Hyclatecapsule100 mg/1oralDAVA Pharmaceuticals, Inc.1984-09-11Not applicableUs
Doxycycline Hyclatetablet, film coated20 mg/1oralBurke Therapeutics, LLC2014-09-29Not applicableUs
Doxycycline Hyclatetablet100 mg/1oralActavis Pharma, Inc.1983-02-02Not applicableUs
Doxycycline Hyclatecapsule50 mg/1oralAv Pak2014-06-05Not applicableUs
Doxycycline Hyclatetablet100 mg/1oralAphena Pharma Solutions (Formerly Test Pak)2011-07-14Not applicableUs
Doxycycline Hyclatecapsule50 mg/1oralAidarex Pharmaceuticals LLC1982-10-13Not applicableUs
Doxycycline Hyclatecapsule100 mg/1oralCitron Pharma LLC1984-09-11Not applicableUs
Doxycycline Hyclatecapsule100 mg/1oralbryant ranch prepack1984-11-07Not applicableUs
Doxycycline Hyclatetablet, film coated100 mg/1oralCHARTWELL GOVERNMENTAL & SPECIALTY RX LLC1984-09-11Not applicableUs
Doxycycline Hyclatecapsule100 mg/1oralLake Erie Medical DBA Quality Care Products LLC1984-09-11Not applicableUs
Doxycycline Hyclatetablet100 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation1983-02-02Not applicableUs
Doxycycline Hyclatecapsule50 mg/1oralHarris Pharmaceutical, Inc1984-09-11Not applicableUs
Doxycycline Hyclatetablet100 mg/1oralPreferred Pharmaceuticals, Inc.2013-12-17Not applicableUs
Doxycycline Hyclatetablet, delayed release75 mg/1oralMylan Pharmaceuticals Inc.2010-12-30Not applicableUs
Doxycycline Hyclatecapsule, gelatin coated100 mg/1oralA S Medication Solutions Llc1984-05-07Not applicableUs
Doxycycline Hyclatecapsule, gelatin coated100 mg/1oralApace Packaging LLC1984-05-07Not applicableUs
Doxycycline Hyclatetablet100 mg/1oralPutney, Inc.2015-02-20Not applicableUs
Doxycycline Hyclatetablet100 mg/1oralA S Medication Solutions Llc1983-02-02Not applicableUs
Doxycycline Hyclatecapsule, gelatin coated100 mg/1oralPd Rx Pharmaceuticals, Inc.1984-05-07Not applicableUs
Doxycycline Hyclate Capsulescapsule50 mg/1oralHikma Pharmaceutical1990-09-01Not applicableUs
Doxycycline Hyclate Capsulescapsule100 mg/1oralHikma Pharmaceutical1990-09-01Not applicableUs
Doxycycline Hyclate Delayed Releasetablet, delayed release75 mg/1oralHeritage Pharmaceuticals Inc.2013-04-30Not applicableUs
Doxycycline Hyclate Delayed Releasetablet, delayed release100 mg/1oralHeritage Pharmaceuticals Inc.2013-04-30Not applicableUs
Doxycycline Hyclate Delayed Releasetablet, delayed release150 mg/1oralHeritage Pharmaceuticals Inc.2013-04-30Not applicableUs
Doxycycline Monohydratetablet100 mg/1oralAmerican Health Packaging2014-12-15Not applicableUs
Mondoxynecapsule75 mg/75mgoralOculus Innovative Scicences2015-05-28Not applicableUs
Mondoxynecapsule50 mg/50mgoralOculus Innovative Sciences2015-05-28Not applicableUs
Mondoxyne Nl 100mgcapsule100 mg/100mgoralOculus Innovative Sciences2015-05-28Not applicableUs
Morgidoxcapsule100 mg/1oralMedimetriks Pharmaceuticals, Inc.2011-03-15Not applicableUs
Morgidoxcapsule100 mg/1oralMedimetriks Pharmaceuticals, Inc.2011-03-15Not applicableUs
Morgidoxcapsule100 mg/1oralMedimetriks Pharmaceuticals, Inc.2011-03-15Not applicableUs
Morgidoxcapsule100 mg/1oralMedimetriks Pharmaceuticals, Inc.2011-03-15Not applicableUs
Ocudoxcapsule50 mg/1oralO Cu Soft Inc.2011-04-01Not applicableUs
Oraceacapsule, delayed release pellets40 mg/1oralPhysicians Total Care, Inc.2006-09-29Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
DoxyGalpharma
DoxycinLaboratoire Riva
DoxylinActavis
JenacyclinNot Available
MicrodoxMicro Labs
NicAzelDoxyKitNot Available
Nu-DoxycyclineNu-Pharm
SupracyclinGrünenthal
VibramycinPfizer
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Doxycycline calcium
94088-85-4
Thumb
  • InChI Key: IYECPECUTCOMMD-QFWOMMJSSA-N
  • Monoisotopic Mass: 524.0762532
  • Average Mass: 524.594
DBSALT001217
Doxycycline hyclate
24390-14-5
Thumb
  • InChI Key: HALQELOKLVRWRI-VDBOFHIQSA-N
  • Monoisotopic Mass: 1024.3123164
  • Average Mass: 1025.88
DBSALT000896
Doxycycline hydrochloride
10592-13-9
Thumb
  • InChI Key: RUYHIJHUVHIMIR-CVHRZJFOSA-N
  • Monoisotopic Mass: 480.1299435
  • Average Mass: 480.9
DBSALT000897
Categories
UNII334895S862
CAS number564-25-0
WeightAverage: 444.4346
Monoisotopic: 444.153265754
Chemical FormulaC22H24N2O8
InChI KeyInChIKey=JBIWCJUYHHGXTC-AKNGSSGZSA-N
InChI
InChI=1S/C22H24N2O8/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29/h4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31)/t7-,10+,14+,15-,17-,22-/m0/s1
IUPAC Name
(4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
SMILES
[H][C@@]12[C@@H](C)C3=C(C(O)=CC=C3)C(=O)C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@]1([H])[[email protected]]2O
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as tetracyclines. These are polyketides having an octahydrotetracene-2-carboxamide skeleton, substituted with many hydroxy and other groups.
KingdomOrganic compounds
Super ClassPhenylpropanoids and polyketides
ClassTetracyclines
Sub ClassNot Available
Direct ParentTetracyclines
Alternative Parents
Substituents
  • Tetracycline
  • Tetracene
  • Naphthacene
  • Anthracene carboxylic acid or derivatives
  • Tetralin
  • Aryl ketone
  • Aralkylamine
  • Benzenoid
  • Vinylogous acid
  • Tertiary alcohol
  • Tertiary aliphatic amine
  • Tertiary amine
  • Secondary alcohol
  • Primary carboxylic acid amide
  • Polyol
  • Ketone
  • Carboxamide group
  • Enol
  • Carboxylic acid derivative
  • Carboxylic acid amide
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Amine
  • Alcohol
  • Aromatic homopolycyclic compound
Molecular FrameworkAromatic homopolycyclic compounds
External Descriptors
Pharmacology
IndicationDoxycycline is indicated for use in respiratory tract infections caused by Mycoplasma pneumoniae, Haemophilus influenzae, Streptococcus pneumoniae, Legionella spp., or Klebsiella spp. It is also used for prophylaxis of malaria. Doxycycline is indicated for a variety of bacterial infections, from Mycobacterium fortuitum and M. marinum, to susceptible E. coli and Brucella spp. It can be used as an alternative to treating plague, tetanus, Campylobacter fetus
PharmacodynamicsDoxycycline, a long-acting tetracycline derived from oxytetracycline, is used to inhibit bacterial protein synthesis and treat non-gonococcal urethritis and cervicitis, exacerbations of bronchitis in patients with COPD, and adult periodontitis.
Mechanism of actionDoxycycline, like minocycline, is lipophilic and can pass through the lipid bilayer of bacteria. Doxycycline reversibly binds to the 30 S ribosomal subunits and possibly the 50S ribosomal subunit(s), blocking the binding of aminoacyl tRNA to the mRNA and inhibiting bacterial protein synthesis. Doxycycline prevents the normal function of the apicoplast of Plasmodium falciparum, a malaria causing organism.
Related Articles
AbsorptionCompletely absorbed following oral administration.
Volume of distributionNot Available
Protein binding>90%
Metabolism

Hepatic

Route of eliminationThey are concentrated by the liver in the bile and excreted in the urine and feces at high concentrations in a biologically active form.
Half life18-22 hours
ClearanceNot Available
ToxicitySymptoms of overdose include anorexia, nausea, diarrhoea, glossitis, dysphagia, enterocolitis and inflammatory lesions (with monilial overgrowth) in the anogenital region, skin reactions such as maculopapular and erythematous rashes, exfoliative dermatitis, photosensitivity, hypersensitivity reactions such as urticaria, angioneurotic oedema, anaphylaxis, anaphyl-actoid purpura, pericarditis, and exacerbation of systemic lupus erythematosus, benign intracranial hypertension in adults disappearing on discontinuation of the medicine, haematologic abnormalities such as haemolytic anaemia, thrombocytopenia, neutropenia, and eosinophilia. LD50=262 mg/kg (I.P. in rat).
Affected organisms
  • Enteric bacteria and other eubacteria
  • Treponema pallidum
  • Leptospira interrogans
  • Clostridium perfringens
  • Borrelia burgdorferi
  • Brucella abortus
  • Brucella canis
  • Chlamydia pneumoniae
  • Chlamydia trachomatis
  • Helicobacter pylori
  • Mycoplasma pneumoniae
  • Neisseria gonorrhoeae
  • Rickettsia rickettsii
  • Vibrio cholerae
  • Yersinia pestis
  • Chlamydia psittaci
Pathways
PathwayCategorySMPDB ID
Doxycycline Action PathwayDrug actionSMP00291
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.85
Blood Brain Barrier-0.9881
Caco-2 permeable-0.8706
P-glycoprotein substrateSubstrate0.699
P-glycoprotein inhibitor INon-inhibitor0.8038
P-glycoprotein inhibitor IINon-inhibitor0.8628
Renal organic cation transporterNon-inhibitor0.9562
CYP450 2C9 substrateNon-substrate0.8008
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateSubstrate0.6551
CYP450 1A2 substrateNon-inhibitor0.9045
CYP450 2C9 inhibitorNon-inhibitor0.9144
CYP450 2D6 inhibitorNon-inhibitor0.9293
CYP450 2C19 inhibitorNon-inhibitor0.9099
CYP450 3A4 inhibitorNon-inhibitor0.8567
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8086
Ames testNon AMES toxic0.9132
CarcinogenicityNon-carcinogens0.8632
BiodegradationNot ready biodegradable0.9941
Rat acute toxicity2.3159 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9946
hERG inhibition (predictor II)Non-inhibitor0.7466
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Mylan pharmaceuticals inc
  • Par pharmaceutical inc
  • Ranbaxy laboratories ltd
  • Sandoz inc
  • Watson laboratories inc
  • Watson pharmaceuticals inc
  • Galderma laboratories lp
  • Rachelle laboratories inc
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Pfizer laboratories div pfizer inc
  • Lannett holdings inc
  • Mutual pharmaceutical co inc
  • Pliva inc
  • Mayne pharma international faulding pharm
  • Warner chilcott bermuda ltd
  • Medicis pharmaceutical corp
  • Halsey drug co inc
  • Heather drug co inc
  • Interpharm inc
  • Private formulations inc
  • Ranbaxy pharmaceuticals inc
  • Superpharm corp
  • Warner chilcott div warner lambert co
  • West ward pharmaceutical corp
  • Teva pharmaceuticals usa inc
  • Collagenex inc
  • App pharmaceuticals llc
  • Baxter healthcare corp anesthesia and critical care
  • Bedford laboratories div ben venue laboratories inc
  • Tolmar inc
  • Corepharma llc
  • Larken laboratories inc
  • Mutual pharmacal co
  • Truxton inc
  • Vintage pharmaceuticals inc
Packagers
Dosage forms
FormRouteStrength
Tablet, coatedoral150 mg/1
Tablet, coatedoral75 mg/1
Tabletoral20 mg/1
Gel (controlled-release)subgingival44 mg
Kitoral
Tablet, delayed releaseoral200 mg/1
Tablet, delayed releaseoral50 mg/1
Capsule (sustained-release)oral100 mg
Injection, powder, lyophilized, for solutionintravenous100 mg/100mg
Tabletoral100 mg
Capsuleoral150 mg/1
For suspensionoral25 mg/5mL
Injection, powder, lyophilized, for solutionintravenous100 mg/10mL
Tabletoral100 mg/1
Tabletoral150 mg/1
Tabletoral50 mg/1
Tabletoral75 mg/1
Tablet, coatedoral100 mg/1
Tablet, film coatedoral100 mg/1
Tablet, film coatedoral150 mg/1
Tablet, film coatedoral50 mg/1
Tablet, film coatedoral75 mg/1
Capsuleoral50 mg/1
Capsule, gelatin coatedoral100 mg/1
Capsule, gelatin coatedoral50 mg/1
Tablet, delayed releaseoral100 mg/1
Tablet, delayed releaseoral150 mg/1
Tablet, delayed releaseoral75 mg/1
Tablet, film coatedoral20 mg/1
Capsuleoral75 mg/1
Capsuleoral50 mg/50mg
Capsuleoral75 mg/75mg
Capsuleoral100 mg/100mg
Capsuleoral40 mg/1
Capsule, delayed release pelletsoral40 mg/1
Capsuleoral20 mg
Capsuleoral100 mg
Syruporal50 mg/5mL
Capsuleoral100 mg/1
Powderintravenous100 mg
Powder, for suspensionoral25 mg/5mL
Prices
Unit descriptionCostUnit
Vibramycin 25 mg/5ml Suspension 60ml Bottle36.29USD bottle
Adoxa pak 1-150 mg tablet19.93USD tablet
Doryx 150 mg Enteric Coated Tabs17.51USD tab
Doryx dr 150 mg tablet16.83USD tablet
Doxycycline hyc 100 mg vial14.16USD vial
Adoxa 100 mg tablet13.86USD tablet
Monodox 100 mg capsule13.46USD capsule
Adoxa 75 mg tablet12.77USD tablet
Oracea 40 mg Delayed Release Capsule12.44USD capsule
Oracea 40 mg capsule11.96USD capsule
Avidoxy 100 mg tablet11.52USD tablet
Monodox 75 mg capsule11.02USD capsule
Doryx 100 mg Enteric Coated Tabs10.31USD tab
Doryx dr 100 mg tablet9.91USD tablet
Adoxa pak 1-100 mg tablet9.88USD tablet
Doxycycline Monohydrate 150 mg tablet9.51USD tablet
Adoxa 50 mg tablet9.29USD tablet
Doxycycline mono 150 mg tablet9.13USD tablet
Doryx 75 mg Enteric Coated Tabs8.76USD tab
Doryx dr 75 mg tablet8.42USD tablet
Vibramycin 100 mg capsule6.67USD capsule
Vibra-tabs 100 mg tablet6.67USD tablet
Monodox 50 mg capsule6.0USD capsule
Doxycycline mono 100 mg tablet5.98USD tablet
Periostat 20 mg tablet5.75USD tablet
Doxycycline mono 75 mg tablet5.74USD tablet
Doxycycline Monohydrate 100 mg tablet5.12USD tablet
Doxycycline mono 50 mg tablet4.17USD tablet
Doxycycline Monohydrate 50 mg tablet3.0USD tablet
Doxycycline hyclate powder2.56USD g
Vibramycin 50 mg capsule2.41USD capsule
Doxycycline Monohydrate 100 mg capsule2.22USD capsule
Vibramycin 100 mg Capsule1.91USD capsule
Doxycycline Monohydrate 50 mg capsule1.51USD capsule
Doxycycline hyclate 100 mg tablet1.28USD tablet
Doxycycline hyclate 20 mg tablet1.28USD tablet
Doxycycline Hyclate 100 mg capsule1.18USD capsule
Doxycycline Hyclate 50 mg capsule0.76USD capsule
Vibramycin 50 mg/5ml Syrup0.67USD ml
Vibramycin 50 mg/5 ml syrup0.64USD ml
Apo-Doxy 100 mg Capsule0.61USD capsule
Apo-Doxy 100 mg Tablet0.61USD tablet
Doxycin 100 mg Capsule0.61USD capsule
Doxycin 100 mg Tablet0.61USD tablet
Novo-Doxylin 100 mg Capsule0.61USD capsule
Novo-Doxylin 100 mg Tablet0.61USD tablet
Nu-Doxycycline 100 mg Capsule0.61USD capsule
Pms-Doxycycline 100 mg Capsule0.61USD capsule
Pms-Doxycycline 100 mg Tablet0.61USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US5789395 No1996-08-302016-08-30Us
US5919775 No1996-08-302016-08-30Us
US6958161 No2002-12-152022-12-15Us
US7211267 No2002-04-052022-04-05Us
US7232572 No2002-04-052022-04-05Us
US7749532 No2007-12-192027-12-19Us
US8206740 No2005-12-242025-12-24Us
US8394405 No2004-04-072024-04-07Us
US8394406 No2004-04-072024-04-07Us
US8470364 No2004-04-072024-04-07Us
US8603506 No2002-04-052022-04-05Us
US8709478 No2004-04-072024-04-07Us
US8715724 No2008-02-032028-02-03Us
US9241946 No2002-04-052022-04-05Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point201 °CNot Available
water solubility630 mg/L (at 25 °C)YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP-0.02SANGSTER (1994)
logS-2.87ADME Research, USCD
Predicted Properties
PropertyValueSource
Water Solubility0.63 mg/mLALOGPS
logP-0.72ALOGPS
logP-3.4ChemAxon
logS-2.9ALOGPS
pKa (Strongest Acidic)-2.2ChemAxon
pKa (Strongest Basic)7.75ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count9ChemAxon
Hydrogen Donor Count6ChemAxon
Polar Surface Area181.62 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity113.89 m3·mol-1ChemAxon
Polarizability42.88 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
References
Synthesis Reference

Dai-Wu Seol, “DNA cassette for the production of secretable recombinant trimeric TRAIL proteins, tetracycline/ doxycycline-inducible adeno-associated virus vector, their combination and use in gene therapy.” U.S. Patent US20020128438, issued September 12, 2002.

US20020128438
General References
  1. Dahl EL, Shock JL, Shenai BR, Gut J, DeRisi JL, Rosenthal PJ: Tetracyclines specifically target the apicoplast of the malaria parasite Plasmodium falciparum. Antimicrob Agents Chemother. 2006 Sep;50(9):3124-31. [PubMed:16940111 ]
  2. Hoerauf A, Mand S, Fischer K, Kruppa T, Marfo-Debrekyei Y, Debrah AY, Pfarr KM, Adjei O, Buttner DW: Doxycycline as a novel strategy against bancroftian filariasis-depletion of Wolbachia endosymbionts from Wuchereria bancrofti and stop of microfilaria production. Med Microbiol Immunol. 2003 Nov;192(4):211-6. Epub 2003 Mar 5. [PubMed:12684759 ]
  3. Taylor MJ, Makunde WH, McGarry HF, Turner JD, Mand S, Hoerauf A: Macrofilaricidal activity after doxycycline treatment of Wuchereria bancrofti: a double-blind, randomised placebo-controlled trial. Lancet. 2005 Jun 18-24;365(9477):2116-21. [PubMed:15964448 ]
External Links
ATC CodesA01AB22J01AA02
AHFS Codes
  • 08:12.24
  • 52:04.04
PDB Entries
FDA labelDownload (48.1 KB)
MSDSDownload (73.4 KB)
Interactions
Drug Interactions
Drug
AbirateroneThe metabolism of Abiraterone can be decreased when combined with Doxycycline.
AcenocoumarolThe metabolism of Acenocoumarol can be decreased when combined with Doxycycline.
AcepromazineThe serum concentration of Acepromazine can be increased when it is combined with Doxycycline.
AcetaminophenThe metabolism of Acetaminophen can be decreased when combined with Doxycycline.
AdinazolamThe metabolism of Adinazolam can be decreased when combined with Doxycycline.
AlbendazoleThe metabolism of Albendazole can be decreased when combined with Doxycycline.
AlclometasoneThe metabolism of Alclometasone can be decreased when combined with Doxycycline.
AlfentanilThe metabolism of Alfentanil can be decreased when combined with Doxycycline.
AlfuzosinThe metabolism of Alfuzosin can be decreased when combined with Doxycycline.
AlimemazineThe serum concentration of Alimemazine can be increased when it is combined with Doxycycline.
AliskirenThe metabolism of Aliskiren can be decreased when combined with Doxycycline.
AllylestrenolThe metabolism of Allylestrenol can be decreased when combined with Doxycycline.
AlmotriptanThe metabolism of Almotriptan can be decreased when combined with Doxycycline.
AlogliptinThe metabolism of Alogliptin can be decreased when combined with Doxycycline.
AlosetronThe metabolism of Alosetron can be decreased when combined with Doxycycline.
AlprazolamThe metabolism of Alprazolam can be decreased when combined with Doxycycline.
AmbrisentanThe metabolism of Ambrisentan can be decreased when combined with Doxycycline.
AmbroxolThe metabolism of Ambroxol can be decreased when combined with Doxycycline.
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Doxycycline.
AminophyllineThe metabolism of Aminophylline can be decreased when combined with Doxycycline.
AmiodaroneThe metabolism of Amiodarone can be decreased when combined with Doxycycline.
AmitriptylineThe metabolism of Amitriptyline can be decreased when combined with Doxycycline.
AmlodipineThe metabolism of Amlodipine can be decreased when combined with Doxycycline.
AmobarbitalThe serum concentration of Doxycycline can be decreased when it is combined with Amobarbital.
AmprenavirThe metabolism of Amprenavir can be decreased when combined with Doxycycline.
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Doxycycline.
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Doxycycline.
ApremilastThe metabolism of Apremilast can be decreased when combined with Doxycycline.
AprepitantThe metabolism of Aprepitant can be decreased when combined with Doxycycline.
ArgatrobanThe metabolism of Argatroban can be decreased when combined with Doxycycline.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Doxycycline.
ArtemetherThe risk or severity of adverse effects can be increased when Artemether is combined with Doxycycline.
ArtemetherThe metabolism of Artemether can be decreased when combined with Doxycycline.
AsenapineThe metabolism of Asenapine can be decreased when combined with Doxycycline.
AstemizoleThe metabolism of Astemizole can be decreased when combined with Doxycycline.
AtazanavirThe metabolism of Atazanavir can be decreased when combined with Doxycycline.
AtorvastatinThe metabolism of Atorvastatin can be decreased when combined with Doxycycline.
AvanafilThe metabolism of Avanafil can be decreased when combined with Doxycycline.
AxitinibThe metabolism of Axitinib can be decreased when combined with Doxycycline.
AzelastineThe metabolism of Azelastine can be decreased when combined with Doxycycline.
AzithromycinThe metabolism of Azithromycin can be decreased when combined with Doxycycline.
BanoxantroneThe metabolism of Banoxantrone can be decreased when combined with Doxycycline.
BarbitalThe serum concentration of Doxycycline can be decreased when it is combined with Barbital.
BedaquilineThe metabolism of Bedaquiline can be decreased when combined with Doxycycline.
BenzphetamineThe metabolism of Benzphetamine can be decreased when combined with Doxycycline.
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Doxycycline.
BexaroteneThe metabolism of Bexarotene can be decreased when combined with Doxycycline.
BezafibrateThe metabolism of Bezafibrate can be decreased when combined with Doxycycline.
BicalutamideThe metabolism of Bicalutamide can be decreased when combined with Doxycycline.
BisoprololThe metabolism of Bisoprolol can be decreased when combined with Doxycycline.
BoceprevirThe metabolism of Boceprevir can be decreased when combined with Doxycycline.
BortezomibThe metabolism of Bortezomib can be decreased when combined with Doxycycline.
BosentanThe serum concentration of Bosentan can be increased when it is combined with Doxycycline.
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Doxycycline.
Brentuximab vedotinThe metabolism of Brentuximab vedotin can be decreased when combined with Doxycycline.
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Doxycycline.
BrinzolamideThe metabolism of Brinzolamide can be decreased when combined with Doxycycline.
BromazepamThe metabolism of Bromazepam can be decreased when combined with Doxycycline.
BromocriptineThe metabolism of Bromocriptine can be decreased when combined with Doxycycline.
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Doxycycline.
BudesonideThe metabolism of Budesonide can be decreased when combined with Doxycycline.
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Doxycycline.
BuprenorphineThe metabolism of Buprenorphine can be decreased when combined with Doxycycline.
BupropionThe metabolism of Bupropion can be decreased when combined with Doxycycline.
BuspironeThe metabolism of Buspirone can be decreased when combined with Doxycycline.
BusulfanThe metabolism of Busulfan can be decreased when combined with Doxycycline.
CabazitaxelThe metabolism of Cabazitaxel can be decreased when combined with Doxycycline.
CabergolineThe metabolism of Cabergoline can be decreased when combined with Doxycycline.
CabozantinibThe metabolism of Cabozantinib can be decreased when combined with Doxycycline.
CaffeineThe metabolism of Caffeine can be decreased when combined with Doxycycline.
CalcitriolThe metabolism of Calcitriol can be decreased when combined with Doxycycline.
CanagliflozinThe metabolism of Canagliflozin can be decreased when combined with Doxycycline.
CarbamazepineThe serum concentration of Doxycycline can be decreased when it is combined with Carbamazepine.
CarbamazepineThe metabolism of Carbamazepine can be decreased when combined with Doxycycline.
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Doxycycline.
CariprazineThe metabolism of Cariprazine can be decreased when combined with Doxycycline.
CarvedilolThe metabolism of Carvedilol can be decreased when combined with Doxycycline.
CelecoxibThe metabolism of Celecoxib can be decreased when combined with Doxycycline.
CeliprololThe metabolism of Celiprolol can be decreased when combined with Doxycycline.
CephalexinThe metabolism of Cephalexin can be decreased when combined with Doxycycline.
CerivastatinThe metabolism of Cerivastatin can be decreased when combined with Doxycycline.
CevimelineThe metabolism of Cevimeline can be decreased when combined with Doxycycline.
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be decreased when combined with Doxycycline.
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Doxycycline.
ChloroquineThe metabolism of Chloroquine can be decreased when combined with Doxycycline.
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Doxycycline.
ChlorpromazineThe serum concentration of Chlorpromazine can be increased when it is combined with Doxycycline.
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Doxycycline.
CholecalciferolThe metabolism of Cholecalciferol can be decreased when combined with Doxycycline.
CiclesonideThe metabolism of Ciclesonide can be decreased when combined with Doxycycline.
CilostazolThe metabolism of Cilostazol can be decreased when combined with Doxycycline.
CinacalcetThe metabolism of Cinacalcet can be decreased when combined with Doxycycline.
CisaprideThe metabolism of Cisapride can be decreased when combined with Doxycycline.
CitalopramThe metabolism of Citalopram can be decreased when combined with Doxycycline.
ClarithromycinThe metabolism of Clarithromycin can be decreased when combined with Doxycycline.
ClindamycinThe metabolism of Clindamycin can be decreased when combined with Doxycycline.
ClobazamThe metabolism of Clobazam can be decreased when combined with Doxycycline.
ClofazimineThe metabolism of Clofazimine can be decreased when combined with Doxycycline.
ClofibrateThe metabolism of Clofibrate can be decreased when combined with Doxycycline.
clomethiazoleThe metabolism of clomethiazole can be decreased when combined with Doxycycline.
ClomipramineThe metabolism of Clomipramine can be decreased when combined with Doxycycline.
ClonazepamThe metabolism of Clonazepam can be decreased when combined with Doxycycline.
ClonidineThe metabolism of Clonidine can be decreased when combined with Doxycycline.
ClopidogrelThe metabolism of Clopidogrel can be decreased when combined with Doxycycline.
ClorazepateThe metabolism of Clorazepate can be decreased when combined with Doxycycline.
ClotiazepamThe metabolism of Clotiazepam can be decreased when combined with Doxycycline.
ClozapineThe metabolism of Clozapine can be decreased when combined with Doxycycline.
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Doxycycline.
CocaineThe metabolism of Cocaine can be decreased when combined with Doxycycline.
CodeineThe metabolism of Codeine can be decreased when combined with Doxycycline.
ColchicineThe metabolism of Colchicine can be decreased when combined with Doxycycline.
ConivaptanThe metabolism of Conivaptan can be decreased when combined with Doxycycline.
Conjugated Equine EstrogensThe metabolism of Conjugated Equine Estrogens can be decreased when combined with Doxycycline.
Cortisone acetateThe metabolism of Cortisone acetate can be decreased when combined with Doxycycline.
CrizotinibThe metabolism of Crizotinib can be decreased when combined with Doxycycline.
CyclobenzaprineThe metabolism of Cyclobenzaprine can be decreased when combined with Doxycycline.
CyclophosphamideThe metabolism of Cyclophosphamide can be decreased when combined with Doxycycline.
CyclosporineThe metabolism of Cyclosporine can be decreased when combined with Doxycycline.
CytarabineThe metabolism of Cytarabine can be decreased when combined with Doxycycline.
DabrafenibThe metabolism of Dabrafenib can be decreased when combined with Doxycycline.
DaclatasvirThe metabolism of Daclatasvir can be decreased when combined with Doxycycline.
DantroleneThe metabolism of Dantrolene can be decreased when combined with Doxycycline.
DapagliflozinThe metabolism of Dapagliflozin can be decreased when combined with Doxycycline.
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Doxycycline.
DapsoneThe metabolism of Dapsone can be decreased when combined with Doxycycline.
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Doxycycline.
DarunavirThe metabolism of Darunavir can be decreased when combined with Doxycycline.
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Doxycycline.
DasatinibThe metabolism of Dasatinib can be decreased when combined with Doxycycline.
DaunorubicinThe metabolism of Daunorubicin can be decreased when combined with Doxycycline.
DehydroepiandrosteroneThe metabolism of Dehydroepiandrosterone can be decreased when combined with Doxycycline.
DelavirdineThe metabolism of Delavirdine can be decreased when combined with Doxycycline.
DesvenlafaxineThe metabolism of Desvenlafaxine can be decreased when combined with Doxycycline.
DexamethasoneThe metabolism of Dexamethasone can be decreased when combined with Doxycycline.
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Doxycycline.
DextropropoxypheneThe metabolism of Dextropropoxyphene can be decreased when combined with Doxycycline.
DiazepamThe metabolism of Diazepam can be decreased when combined with Doxycycline.
DiclofenacThe metabolism of Diclofenac can be decreased when combined with Doxycycline.
DigitoxinThe metabolism of Digitoxin can be decreased when combined with Doxycycline.
DigoxinThe metabolism of Digoxin can be decreased when combined with Doxycycline.
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Doxycycline.
DihydroergotamineThe metabolism of Dihydroergotamine can be decreased when combined with Doxycycline.
DiltiazemThe metabolism of Diltiazem can be decreased when combined with Doxycycline.
DisopyramideThe metabolism of Disopyramide can be decreased when combined with Doxycycline.
DisulfiramThe metabolism of Disulfiram can be decreased when combined with Doxycycline.
DocetaxelThe metabolism of Docetaxel can be decreased when combined with Doxycycline.
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Doxycycline.
DolasetronThe metabolism of Dolasetron can be decreased when combined with Doxycycline.
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Doxycycline.
DonepezilThe metabolism of Donepezil can be decreased when combined with Doxycycline.
DorzolamideThe metabolism of Dorzolamide can be decreased when combined with Doxycycline.
DoxepinThe metabolism of Doxepin can be decreased when combined with Doxycycline.
DoxorubicinThe metabolism of Doxorubicin can be decreased when combined with Doxycycline.
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Doxycycline.
DronedaroneThe metabolism of Dronedarone can be decreased when combined with Doxycycline.
DutasterideThe metabolism of Dutasteride can be decreased when combined with Doxycycline.
EfavirenzThe metabolism of Efavirenz can be decreased when combined with Doxycycline.
EletriptanThe metabolism of Eletriptan can be decreased when combined with Doxycycline.
EliglustatThe metabolism of Eliglustat can be decreased when combined with Doxycycline.
ElvitegravirThe metabolism of Elvitegravir can be decreased when combined with Doxycycline.
EnalaprilThe metabolism of Enalapril can be decreased when combined with Doxycycline.
EnzalutamideThe metabolism of Enzalutamide can be decreased when combined with Doxycycline.
EpinastineThe metabolism of Epinastine can be decreased when combined with Doxycycline.
EplerenoneThe metabolism of Eplerenone can be decreased when combined with Doxycycline.
ErgocalciferolThe metabolism of Ergocalciferol can be decreased when combined with Doxycycline.
Ergoloid mesylateThe metabolism of Ergoloid mesylate can be decreased when combined with Doxycycline.
ErgonovineThe metabolism of Ergonovine can be decreased when combined with Doxycycline.
ErgotamineThe metabolism of Ergotamine can be decreased when combined with Doxycycline.
ErlotinibThe metabolism of Erlotinib can be decreased when combined with Doxycycline.
ErythromycinThe metabolism of Erythromycin can be decreased when combined with Doxycycline.
EscitalopramThe metabolism of Escitalopram can be decreased when combined with Doxycycline.
EsomeprazoleThe metabolism of Esomeprazole can be decreased when combined with Doxycycline.
EstazolamThe metabolism of Estazolam can be decreased when combined with Doxycycline.
EstradiolThe metabolism of Estradiol can be decreased when combined with Doxycycline.
Estradiol valerate/DienogestThe metabolism of Estradiol valerate/Dienogest can be decreased when combined with Doxycycline.
EstramustineThe metabolism of Estramustine can be decreased when combined with Doxycycline.
EstroneThe metabolism of Estrone can be decreased when combined with Doxycycline.
Estrone sulfateThe metabolism of Estrone sulfate can be decreased when combined with Doxycycline.
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Doxycycline.
EthanolThe metabolism of Ethanol can be decreased when combined with Doxycycline.
Ethinyl EstradiolThe metabolism of Ethinyl Estradiol can be decreased when combined with Doxycycline.
EthosuximideThe metabolism of Ethosuximide can be decreased when combined with Doxycycline.
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Doxycycline.
EtonogestrelThe metabolism of Etonogestrel can be decreased when combined with Doxycycline.
EtoposideThe metabolism of Etoposide can be decreased when combined with Doxycycline.
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Doxycycline.
EtravirineThe metabolism of Etravirine can be decreased when combined with Doxycycline.
EverolimusThe metabolism of Everolimus can be decreased when combined with Doxycycline.
ExemestaneThe metabolism of Exemestane can be decreased when combined with Doxycycline.
FamciclovirThe metabolism of Famciclovir can be decreased when combined with Doxycycline.
FelbamateThe metabolism of Felbamate can be decreased when combined with Doxycycline.
FelodipineThe metabolism of Felodipine can be decreased when combined with Doxycycline.
FenofibrateThe metabolism of Fenofibrate can be decreased when combined with Doxycycline.
FentanylThe metabolism of Fentanyl can be decreased when combined with Doxycycline.
FesoterodineThe metabolism of Fesoterodine can be decreased when combined with Doxycycline.
FinasterideThe metabolism of Finasteride can be decreased when combined with Doxycycline.
FingolimodThe metabolism of Fingolimod can be decreased when combined with Doxycycline.
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Doxycycline.
FlunisolideThe metabolism of Flunisolide can be decreased when combined with Doxycycline.
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Doxycycline.
FluorometholoneThe metabolism of Fluorometholone can be decreased when combined with Doxycycline.
FluoxetineThe metabolism of Fluoxetine can be decreased when combined with Doxycycline.
FluphenazineThe serum concentration of Fluphenazine can be increased when it is combined with Doxycycline.
FlurazepamThe metabolism of Flurazepam can be decreased when combined with Doxycycline.
FlutamideThe metabolism of Flutamide can be decreased when combined with Doxycycline.
Fluticasone furoateThe metabolism of Fluticasone furoate can be decreased when combined with Doxycycline.
Fluticasone PropionateThe metabolism of Fluticasone Propionate can be decreased when combined with Doxycycline.
FluvastatinThe metabolism of Fluvastatin can be decreased when combined with Doxycycline.
FosamprenavirThe metabolism of Fosamprenavir can be decreased when combined with Doxycycline.
FosphenytoinThe serum concentration of Doxycycline can be decreased when it is combined with Fosphenytoin.
FulvestrantThe metabolism of Fulvestrant can be decreased when combined with Doxycycline.
GalantamineThe metabolism of Galantamine can be decreased when combined with Doxycycline.
GefitinibThe metabolism of Gefitinib can be decreased when combined with Doxycycline.
GemfibrozilThe metabolism of Gemfibrozil can be decreased when combined with Doxycycline.
GlipizideThe metabolism of Glipizide can be decreased when combined with Doxycycline.
GlyburideThe metabolism of Glyburide can be decreased when combined with Doxycycline.
GranisetronThe metabolism of Granisetron can be decreased when combined with Doxycycline.
GrepafloxacinThe metabolism of Grepafloxacin can be decreased when combined with Doxycycline.
GuanfacineThe metabolism of Guanfacine can be decreased when combined with Doxycycline.
HalofantrineThe metabolism of Halofantrine can be decreased when combined with Doxycycline.
HaloperidolThe metabolism of Haloperidol can be decreased when combined with Doxycycline.
HalothaneThe metabolism of Halothane can be decreased when combined with Doxycycline.
HexobarbitalThe serum concentration of Doxycycline can be decreased when it is combined with Hexobarbital.
HexobarbitalThe metabolism of Hexobarbital can be decreased when combined with Doxycycline.
Histamine PhosphateThe metabolism of Histamine Phosphate can be decreased when combined with Doxycycline.
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Doxycycline.
HydrocortisoneThe metabolism of Hydrocortisone can be decreased when combined with Doxycycline.
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Doxycycline.
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be decreased when combined with Doxycycline.
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Doxycycline.
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Doxycycline resulting in a loss in efficacy.
IloperidoneThe metabolism of Iloperidone can be decreased when combined with Doxycycline.
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Doxycycline.
ImipramineThe metabolism of Imipramine can be decreased when combined with Doxycycline.
ImiquimodThe metabolism of Imiquimod can be decreased when combined with Doxycycline.
IndacaterolThe metabolism of Indacaterol can be decreased when combined with Doxycycline.
IndapamideThe metabolism of Indapamide can be decreased when combined with Doxycycline.
IndinavirThe metabolism of Indinavir can be decreased when combined with Doxycycline.
Ipratropium bromideThe metabolism of Ipratropium bromide can be decreased when combined with Doxycycline.
IrinotecanThe metabolism of Irinotecan can be decreased when combined with Doxycycline.
IsavuconazoniumThe metabolism of Isavuconazonium can be decreased when combined with Doxycycline.
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be decreased when combined with Doxycycline.
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be decreased when combined with Doxycycline.
IsradipineThe metabolism of Isradipine can be decreased when combined with Doxycycline.
ItraconazoleThe metabolism of Itraconazole can be decreased when combined with Doxycycline.
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Doxycycline.
IvacaftorThe metabolism of Ivacaftor can be decreased when combined with Doxycycline.
IvermectinThe metabolism of Ivermectin can be decreased when combined with Doxycycline.
IxabepiloneThe metabolism of Ixabepilone can be decreased when combined with Doxycycline.
IxazomibThe metabolism of Ixazomib can be decreased when combined with Doxycycline.
KetamineThe metabolism of Ketamine can be decreased when combined with Doxycycline.
KetazolamThe metabolism of Ketazolam can be decreased when combined with Doxycycline.
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Doxycycline.
KetoconazoleThe metabolism of Ketoconazole can be decreased when combined with Doxycycline.
LansoprazoleThe metabolism of Lansoprazole can be decreased when combined with Doxycycline.
LapatinibThe metabolism of Lapatinib can be decreased when combined with Doxycycline.
LaquinimodThe metabolism of Laquinimod can be decreased when combined with Doxycycline.
LenvatinibThe metabolism of Lenvatinib can be decreased when combined with Doxycycline.
LercanidipineThe metabolism of Lercanidipine can be decreased when combined with Doxycycline.
LetrozoleThe metabolism of Letrozole can be decreased when combined with Doxycycline.
LevobupivacaineThe metabolism of Levobupivacaine can be decreased when combined with Doxycycline.
LevocetirizineThe metabolism of Levocetirizine can be decreased when combined with Doxycycline.
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be decreased when combined with Doxycycline.
LevomilnacipranThe metabolism of Levomilnacipran can be decreased when combined with Doxycycline.
LevonorgestrelThe metabolism of Levonorgestrel can be decreased when combined with Doxycycline.
LevothyroxineThe metabolism of Levothyroxine can be decreased when combined with Doxycycline.
LidocaineThe metabolism of Lidocaine can be decreased when combined with Doxycycline.
LisurideThe metabolism of Lisuride can be decreased when combined with Doxycycline.
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Doxycycline.
LoperamideThe metabolism of Loperamide can be decreased when combined with Doxycycline.
LopinavirThe metabolism of Lopinavir can be decreased when combined with Doxycycline.
LoratadineThe metabolism of Loratadine can be decreased when combined with Doxycycline.
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Doxycycline.
LosartanThe metabolism of Losartan can be decreased when combined with Doxycycline.
LovastatinThe metabolism of Lovastatin can be decreased when combined with Doxycycline.
LumefantrineThe risk or severity of adverse effects can be increased when Doxycycline is combined with Lumefantrine.
LurasidoneThe metabolism of Lurasidone can be decreased when combined with Doxycycline.
MacitentanThe metabolism of Macitentan can be decreased when combined with Doxycycline.
MaravirocThe metabolism of Maraviroc can be decreased when combined with Doxycycline.
MebendazoleThe metabolism of Mebendazole can be decreased when combined with Doxycycline.
Medroxyprogesterone acetateThe metabolism of Medroxyprogesterone acetate can be decreased when combined with Doxycycline.
MefloquineThe metabolism of Mefloquine can be decreased when combined with Doxycycline.
MeloxicamThe metabolism of Meloxicam can be decreased when combined with Doxycycline.
MesoridazineThe serum concentration of Mesoridazine can be increased when it is combined with Doxycycline.
MethadoneThe metabolism of Methadone can be decreased when combined with Doxycycline.
MethaqualoneThe metabolism of Methaqualone can be decreased when combined with Doxycycline.
MethohexitalThe serum concentration of Doxycycline can be decreased when it is combined with Methohexital.
MethotrimeprazineThe serum concentration of Methotrimeprazine can be increased when it is combined with Doxycycline.
MethoxsalenThe metabolism of Methoxsalen can be decreased when combined with Doxycycline.
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Doxycycline.
Methylene blueThe serum concentration of Methylene blue can be increased when it is combined with Doxycycline.
MethylphenobarbitalThe serum concentration of Doxycycline can be decreased when it is combined with Methylphenobarbital.
MethylprednisoloneThe metabolism of Methylprednisolone can be decreased when combined with Doxycycline.
MethyltestosteroneThe metabolism of Methyltestosterone can be decreased when combined with Doxycycline.
MetronidazoleThe metabolism of Metronidazole can be decreased when combined with Doxycycline.
MexiletineThe metabolism of Mexiletine can be decreased when combined with Doxycycline.
MianserinThe metabolism of Mianserin can be decreased when combined with Doxycycline.
MibefradilThe metabolism of Mibefradil can be decreased when combined with Doxycycline.
MiconazoleThe metabolism of Miconazole can be decreased when combined with Doxycycline.
MidazolamThe metabolism of Midazolam can be decreased when combined with Doxycycline.
MifepristoneThe metabolism of Mifepristone can be decreased when combined with Doxycycline.
MirabegronThe metabolism of Mirabegron can be decreased when combined with Doxycycline.
MirtazapineThe metabolism of Mirtazapine can be decreased when combined with Doxycycline.
ModafinilThe metabolism of Modafinil can be decreased when combined with Doxycycline.
MontelukastThe metabolism of Montelukast can be decreased when combined with Doxycycline.
MoricizineThe serum concentration of Moricizine can be increased when it is combined with Doxycycline.
MorphineThe metabolism of Morphine can be decreased when combined with Doxycycline.
Mycophenolate mofetilThe metabolism of Mycophenolate mofetil can be decreased when combined with Doxycycline.
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Doxycycline.
NaloxoneThe metabolism of Naloxone can be decreased when combined with Doxycycline.
NateglinideThe metabolism of Nateglinide can be decreased when combined with Doxycycline.
NefazodoneThe metabolism of Nefazodone can be decreased when combined with Doxycycline.
NelfinavirThe metabolism of Nelfinavir can be decreased when combined with Doxycycline.
NevirapineThe metabolism of Nevirapine can be decreased when combined with Doxycycline.
NicardipineThe metabolism of Nicardipine can be decreased when combined with Doxycycline.
NicotineThe metabolism of Nicotine can be decreased when combined with Doxycycline.
NifedipineThe metabolism of Nifedipine can be decreased when combined with Doxycycline.
NilotinibThe metabolism of Nilotinib can be decreased when combined with Doxycycline.
NilvadipineThe metabolism of Nilvadipine can be decreased when combined with Doxycycline.
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Doxycycline.
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Doxycycline.
NisoldipineThe metabolism of Nisoldipine can be decreased when combined with Doxycycline.
NitrazepamThe metabolism of Nitrazepam can be decreased when combined with Doxycycline.
NitrendipineThe metabolism of Nitrendipine can be decreased when combined with Doxycycline.
NorethisteroneThe metabolism of Norethisterone can be decreased when combined with Doxycycline.
NorgestrelThe metabolism of Norgestrel can be decreased when combined with Doxycycline.
NortriptylineThe metabolism of Nortriptyline can be decreased when combined with Doxycycline.
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Doxycycline.
OlopatadineThe metabolism of Olopatadine can be decreased when combined with Doxycycline.
OmeprazoleThe metabolism of Omeprazole can be decreased when combined with Doxycycline.
OndansetronThe metabolism of Ondansetron can be decreased when combined with Doxycycline.
OrphenadrineThe metabolism of Orphenadrine can be decreased when combined with Doxycycline.
OspemifeneThe metabolism of Ospemifene can be decreased when combined with Doxycycline.
OxazepamThe metabolism of Oxazepam can be decreased when combined with Doxycycline.
OxybutyninThe metabolism of Oxybutynin can be decreased when combined with Doxycycline.
OxycodoneThe metabolism of Oxycodone can be decreased when combined with Doxycycline.
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Doxycycline.
PaclitaxelThe metabolism of Paclitaxel can be decreased when combined with Doxycycline.
PalbociclibThe metabolism of Palbociclib can be decreased when combined with Doxycycline.
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Doxycycline.
PanobinostatThe metabolism of Panobinostat can be decreased when combined with Doxycycline.
PantoprazoleThe metabolism of Pantoprazole can be decreased when combined with Doxycycline.
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Doxycycline.
ParamethasoneThe metabolism of Paramethasone can be decreased when combined with Doxycycline.
ParecoxibThe metabolism of Parecoxib can be decreased when combined with Doxycycline.
ParicalcitolThe metabolism of Paricalcitol can be decreased when combined with Doxycycline.
ParitaprevirThe metabolism of Paritaprevir can be decreased when combined with Doxycycline.
PazopanibThe metabolism of Pazopanib can be decreased when combined with Doxycycline.
PentamidineThe metabolism of Pentamidine can be decreased when combined with Doxycycline.
PentobarbitalThe serum concentration of Doxycycline can be decreased when it is combined with Pentobarbital.
PerampanelThe metabolism of Perampanel can be decreased when combined with Doxycycline.
PergolideThe metabolism of Pergolide can be decreased when combined with Doxycycline.
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Doxycycline.
PermethrinThe metabolism of Permethrin can be decreased when combined with Doxycycline.
PerphenazineThe serum concentration of Perphenazine can be increased when it is combined with Doxycycline.
PethidineThe metabolism of Pethidine can be decreased when combined with Doxycycline.
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Doxycycline.
PhenobarbitalThe serum concentration of Doxycycline can be decreased when it is combined with Phenobarbital.
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be decreased when combined with Doxycycline.
PhenprocoumonThe metabolism of Phenprocoumon can be decreased when combined with Doxycycline.
PhenytoinThe serum concentration of Doxycycline can be decreased when it is combined with Phenytoin.
PhenytoinThe metabolism of Phenytoin can be decreased when combined with Doxycycline.
Picosulfuric acidThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Doxycycline.
PilocarpineThe metabolism of Pilocarpine can be decreased when combined with Doxycycline.
PimecrolimusThe metabolism of Pimecrolimus can be decreased when combined with Doxycycline.
PimozideThe serum concentration of Pimozide can be increased when it is combined with Doxycycline.
PinacidilThe metabolism of Pinacidil can be decreased when combined with Doxycycline.
PioglitazoneThe metabolism of Pioglitazone can be decreased when combined with Doxycycline.
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Doxycycline.
PodofiloxThe metabolism of Podofilox can be decreased when combined with Doxycycline.
PomalidomideThe metabolism of Pomalidomide can be decreased when combined with Doxycycline.
PonatinibThe metabolism of Ponatinib can be decreased when combined with Doxycycline.
PosaconazoleThe metabolism of Posaconazole can be decreased when combined with Doxycycline.
PrasugrelThe metabolism of Prasugrel can be decreased when combined with Doxycycline.
PravastatinThe metabolism of Pravastatin can be decreased when combined with Doxycycline.
PrazepamThe metabolism of Prazepam can be decreased when combined with Doxycycline.
PraziquantelThe metabolism of Praziquantel can be decreased when combined with Doxycycline.
PrednisoloneThe metabolism of Prednisolone can be decreased when combined with Doxycycline.
PrednisoneThe metabolism of Prednisone can be decreased when combined with Doxycycline.
PrimaquineThe metabolism of Primaquine can be decreased when combined with Doxycycline.
PrimidoneThe serum concentration of Doxycycline can be decreased when it is combined with Primidone.
ProchlorperazineThe serum concentration of Prochlorperazine can be increased when it is combined with Doxycycline.
ProgesteroneThe metabolism of Progesterone can be decreased when combined with Doxycycline.
ProguanilThe metabolism of Proguanil can be decreased when combined with Doxycycline.
PromazineThe serum concentration of Promazine can be increased when it is combined with Doxycycline.
PromethazineThe serum concentration of Promethazine can be increased when it is combined with Doxycycline.
PropafenoneThe serum concentration of Propafenone can be increased when it is combined with Doxycycline.
PropofolThe metabolism of Propofol can be decreased when combined with Doxycycline.
PropranololThe metabolism of Propranolol can be decreased when combined with Doxycycline.
PyrazinamideThe metabolism of Pyrazinamide can be decreased when combined with Doxycycline.
QuazepamThe metabolism of Quazepam can be decreased when combined with Doxycycline.
QuetiapineThe metabolism of Quetiapine can be decreased when combined with Doxycycline.
QuinacrineThe metabolism of Quinacrine can be decreased when combined with Doxycycline.
QuinidineThe metabolism of Quinidine can be decreased when combined with Doxycycline.
QuinineThe metabolism of Quinine can be decreased when combined with Doxycycline.
RabeprazoleThe metabolism of Rabeprazole can be decreased when combined with Doxycycline.
RaloxifeneThe metabolism of Raloxifene can be decreased when combined with Doxycycline.
RamelteonThe metabolism of Ramelteon can be decreased when combined with Doxycycline.
RanolazineThe metabolism of Ranolazine can be decreased when combined with Doxycycline.
ReboxetineThe metabolism of Reboxetine can be decreased when combined with Doxycycline.
RegorafenibThe metabolism of Regorafenib can be decreased when combined with Doxycycline.
RepaglinideThe metabolism of Repaglinide can be decreased when combined with Doxycycline.
RetapamulinThe metabolism of Retapamulin can be decreased when combined with Doxycycline.
RifabutinThe metabolism of Rifabutin can be decreased when combined with Doxycycline.
RifampicinThe serum concentration of Doxycycline can be decreased when it is combined with Rifampicin.
RifampicinThe metabolism of Rifampicin can be decreased when combined with Doxycycline.
RilpivirineThe metabolism of Rilpivirine can be decreased when combined with Doxycycline.
RimonabantThe metabolism of Rimonabant can be decreased when combined with Doxycycline.
RiociguatThe metabolism of Riociguat can be decreased when combined with Doxycycline.
RisperidoneThe metabolism of Risperidone can be decreased when combined with Doxycycline.
RitonavirThe metabolism of Ritonavir can be decreased when combined with Doxycycline.
RivaroxabanThe metabolism of Rivaroxaban can be decreased when combined with Doxycycline.
RofecoxibThe metabolism of Rofecoxib can be decreased when combined with Doxycycline.
RolapitantThe metabolism of Rolapitant can be decreased when combined with Doxycycline.
RomidepsinThe metabolism of Romidepsin can be decreased when combined with Doxycycline.
RopiniroleThe metabolism of Ropinirole can be decreased when combined with Doxycycline.
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Doxycycline.
RosuvastatinThe metabolism of Rosuvastatin can be decreased when combined with Doxycycline.
RotigotineThe metabolism of Rotigotine can be decreased when combined with Doxycycline.
RoxithromycinThe metabolism of Roxithromycin can be decreased when combined with Doxycycline.
RuxolitinibThe metabolism of Ruxolitinib can be decreased when combined with Doxycycline.
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Doxycycline.
SaquinavirThe metabolism of Saquinavir can be decreased when combined with Doxycycline.
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Doxycycline.
SecobarbitalThe serum concentration of Doxycycline can be decreased when it is combined with Secobarbital.
SelegilineThe metabolism of Selegiline can be decreased when combined with Doxycycline.
SelexipagThe metabolism of Selexipag can be decreased when combined with Doxycycline.
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Doxycycline.
SertindoleThe metabolism of Sertindole can be decreased when combined with Doxycycline.
SertralineThe metabolism of Sertraline can be decreased when combined with Doxycycline.
SevofluraneThe metabolism of Sevoflurane can be decreased when combined with Doxycycline.
SibutramineThe metabolism of Sibutramine can be decreased when combined with Doxycycline.
SildenafilThe metabolism of Sildenafil can be decreased when combined with Doxycycline.
SilodosinThe metabolism of Silodosin can be decreased when combined with Doxycycline.
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with Doxycycline.
SimvastatinThe metabolism of Simvastatin can be decreased when combined with Doxycycline.
SirolimusThe metabolism of Sirolimus can be decreased when combined with Doxycycline.
SitagliptinThe metabolism of Sitagliptin can be decreased when combined with Doxycycline.
SolifenacinThe metabolism of Solifenacin can be decreased when combined with Doxycycline.
SonidegibThe metabolism of Sonidegib can be decreased when combined with Doxycycline.
SorafenibThe metabolism of Sorafenib can be decreased when combined with Doxycycline.
SpiramycinThe metabolism of Spiramycin can be decreased when combined with Doxycycline.
SufentanilThe metabolism of Sufentanil can be decreased when combined with Doxycycline.
SulfadiazineThe metabolism of Sulfadiazine can be decreased when combined with Doxycycline.
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be decreased when combined with Doxycycline.
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be decreased when combined with Doxycycline.
SunitinibThe metabolism of Sunitinib can be decreased when combined with Doxycycline.
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Doxycycline.
Synthetic Conjugated Estrogens, AThe metabolism of Synthetic Conjugated Estrogens, A can be decreased when combined with Doxycycline.
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be decreased when combined with Doxycycline.
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Doxycycline.
TadalafilThe metabolism of Tadalafil can be decreased when combined with Doxycycline.
TamoxifenThe metabolism of Tamoxifen can be decreased when combined with Doxycycline.
TamsulosinThe metabolism of Tamsulosin can be decreased when combined with Doxycycline.
TasosartanThe metabolism of Tasosartan can be decreased when combined with Doxycycline.
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be decreased when combined with Doxycycline.
TelaprevirThe metabolism of Telaprevir can be decreased when combined with Doxycycline.
TelithromycinThe metabolism of Telithromycin can be decreased when combined with Doxycycline.
TemazepamThe metabolism of Temazepam can be decreased when combined with Doxycycline.
TemsirolimusThe metabolism of Temsirolimus can be decreased when combined with Doxycycline.
TeniposideThe metabolism of Teniposide can be decreased when combined with Doxycycline.
TerbinafineThe metabolism of Terbinafine can be decreased when combined with Doxycycline.
TerfenadineThe metabolism of Terfenadine can be decreased when combined with Doxycycline.
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Doxycycline.
TestosteroneThe metabolism of Testosterone can be decreased when combined with Doxycycline.
TetracyclineThe metabolism of Tetracycline can be decreased when combined with Doxycycline.
TheophyllineThe metabolism of Theophylline can be decreased when combined with Doxycycline.
ThiamylalThe serum concentration of Doxycycline can be decreased when it is combined with Thiamylal.
ThiethylperazineThe serum concentration of Thiethylperazine can be increased when it is combined with Doxycycline.
ThiopentalThe serum concentration of Doxycycline can be decreased when it is combined with Thiopental.
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Doxycycline.
ThiotepaThe metabolism of Thiotepa can be decreased when combined with Doxycycline.
TiagabineThe metabolism of Tiagabine can be decreased when combined with Doxycycline.
TicagrelorThe metabolism of Ticagrelor can be decreased when combined with Doxycycline.
TiclopidineThe metabolism of Ticlopidine can be decreased when combined with Doxycycline.
TinidazoleThe metabolism of Tinidazole can be decreased when combined with Doxycycline.
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Doxycycline.
TipranavirThe metabolism of Tipranavir can be decreased when combined with Doxycycline.
TofacitinibThe metabolism of Tofacitinib can be decreased when combined with Doxycycline.
TolterodineThe metabolism of Tolterodine can be decreased when combined with Doxycycline.
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Doxycycline.
ToremifeneThe metabolism of Toremifene can be decreased when combined with Doxycycline.
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Doxycycline.
TramadolThe metabolism of Tramadol can be decreased when combined with Doxycycline.
Trastuzumab emtansineThe metabolism of Trastuzumab emtansine can be decreased when combined with Doxycycline.
TrazodoneThe metabolism of Trazodone can be decreased when combined with Doxycycline.
TretinoinThe metabolism of Tretinoin can be decreased when combined with Doxycycline.
TriamcinoloneThe metabolism of Triamcinolone can be decreased when combined with Doxycycline.
TriazolamThe metabolism of Triazolam can be decreased when combined with Doxycycline.
TrifluoperazineThe serum concentration of Trifluoperazine can be increased when it is combined with Doxycycline.
TriflupromazineThe serum concentration of Triflupromazine can be increased when it is combined with Doxycycline.
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Doxycycline.
TrimethoprimThe metabolism of Trimethoprim can be decreased when combined with Doxycycline.
TrimipramineThe metabolism of Trimipramine can be decreased when combined with Doxycycline.
TroglitazoneThe metabolism of Troglitazone can be decreased when combined with Doxycycline.
TroleandomycinThe metabolism of Troleandomycin can be decreased when combined with Doxycycline.
UdenafilThe metabolism of Udenafil can be decreased when combined with Doxycycline.
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Doxycycline.
ValdecoxibThe metabolism of Valdecoxib can be decreased when combined with Doxycycline.
VandetanibThe metabolism of Vandetanib can be decreased when combined with Doxycycline.
VanoxerineThe metabolism of Vanoxerine can be decreased when combined with Doxycycline.
VardenafilThe metabolism of Vardenafil can be decreased when combined with Doxycycline.
VemurafenibThe metabolism of Vemurafenib can be decreased when combined with Doxycycline.
VenlafaxineThe metabolism of Venlafaxine can be decreased when combined with Doxycycline.
VerapamilThe metabolism of Verapamil can be decreased when combined with Doxycycline.
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Doxycycline.
VilanterolThe metabolism of Vilanterol can be decreased when combined with Doxycycline.
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Doxycycline.
VinblastineThe metabolism of Vinblastine can be decreased when combined with Doxycycline.
VincristineThe metabolism of Vincristine can be decreased when combined with Doxycycline.
VindesineThe serum concentration of Vindesine can be increased when it is combined with Doxycycline.
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Doxycycline.
VismodegibThe metabolism of Vismodegib can be decreased when combined with Doxycycline.
VoriconazoleThe metabolism of Voriconazole can be decreased when combined with Doxycycline.
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Doxycycline.
WarfarinThe metabolism of Warfarin can be decreased when combined with Doxycycline.
YohimbineThe metabolism of Yohimbine can be decreased when combined with Doxycycline.
ZafirlukastThe metabolism of Zafirlukast can be decreased when combined with Doxycycline.
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Doxycycline.
ZaleplonThe metabolism of Zaleplon can be decreased when combined with Doxycycline.
ZidovudineThe metabolism of Zidovudine can be decreased when combined with Doxycycline.
ZileutonThe metabolism of Zileuton can be decreased when combined with Doxycycline.
ZiprasidoneThe metabolism of Ziprasidone can be decreased when combined with Doxycycline.
ZolpidemThe metabolism of Zolpidem can be decreased when combined with Doxycycline.
ZomepiracThe metabolism of Zomepirac can be decreased when combined with Doxycycline.
ZonisamideThe metabolism of Zonisamide can be decreased when combined with Doxycycline.
ZopicloneThe metabolism of Zopiclone can be decreased when combined with Doxycycline.
ZuclopenthixolThe serum concentration of Zuclopenthixol can be increased when it is combined with Doxycycline.
Food Interactions
  • Avoid alcohol.
  • Avoid milk, calcium containing dairy products, iron, antacids, or aluminum salts 2 hours before or 6 hours after using antacids while on this medication.
  • Take with a full glass of water Do not take calcium, aluminum, magnesium or Iron supplements within 2 hours of taking this medication.

Targets

Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
yes
Actions
inhibitor
General Function:
Translation repressor activity, nucleic acid binding
Specific Function:
One of two assembly initiator proteins for the 30S subunit, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.With S5 and S12 plays an important role in translational accuracy; many suppressors of streptomycin-dependent mutants of protein S12 are found in this protein, some but not all of which decrease translational accuracy (ram, ribosomal ambiguity muta...
Gene Name:
rpsD
Uniprot ID:
P0A7V8
Molecular Weight:
23468.915 Da
References
  1. Griffin MO, Fricovsky E, Ceballos G, Villarreal F: Tetracyclines: a pleitropic family of compounds with promising therapeutic properties. Review of the literature. Am J Physiol Cell Physiol. 2010 Sep;299(3):C539-48. doi: 10.1152/ajpcell.00047.2010. Epub 2010 Jun 30. [PubMed:20592239 ]
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
yes
Actions
inhibitor
General Function:
Trna binding
Specific Function:
The C-terminal tail plays a role in the affinity of the 30S P site for different tRNAs. Mutations that decrease this affinity are suppressed in the 70S ribosome.
Gene Name:
rpsI
Uniprot ID:
P0A7X3
Molecular Weight:
14856.105 Da
References
  1. Griffin MO, Fricovsky E, Ceballos G, Villarreal F: Tetracyclines: a pleitropic family of compounds with promising therapeutic properties. Review of the literature. Am J Physiol Cell Physiol. 2010 Sep;299(3):C539-48. doi: 10.1152/ajpcell.00047.2010. Epub 2010 Jun 30. [PubMed:20592239 ]
3. 16S rRNA
Kind
Nucleotide
Organism
Enteric bacteria and other eubacteria
Pharmacological action
yes
Actions
inhibitor
References
  1. Pringle M, Fellstrom C, Johansson KE: Decreased susceptibility to doxycycline associated with a 16S rRNA gene mutation in Brachyspira hyodysenteriae. Vet Microbiol. 2007 Jul 20;123(1-3):245-8. Epub 2007 Feb 25. [PubMed:17428623 ]
  2. Kumar S, Kutlin A, Roblin P, Kohlhoff S, Bodetti T, Timms P, Hammerschlag MR: Isolation and antimicrobial susceptibilities of Chlamydial isolates from Western barred bandicoots. J Clin Microbiol. 2007 Feb;45(2):392-4. Epub 2006 Nov 22. [PubMed:17122017 ]
  3. Ross JI, Eady EA, Cove JH, Cunliffe WJ: 16S rRNA mutation associated with tetracycline resistance in a gram-positive bacterium. Antimicrob Agents Chemother. 1998 Jul;42(7):1702-5. [PubMed:9661007 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Protein-arginine deiminase activity
Specific Function:
Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance. Citrullinates histone H1 at 'Arg-54' (to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3' (to form H4R3ci). Acts as...
Gene Name:
PADI4
Uniprot ID:
Q9UM07
Molecular Weight:
74078.65 Da
References
  1. Knuckley B, Luo Y, Thompson PR: Profiling Protein Arginine Deiminase 4 (PAD4): a novel screen to identify PAD4 inhibitors. Bioorg Med Chem. 2008 Jan 15;16(2):739-45. Epub 2007 Oct 13. [PubMed:17964793 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Identical protein binding
Specific Function:
Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
Gene Name:
B2M
Uniprot ID:
P61769
Molecular Weight:
13714.43 Da
References
  1. Giorgetti S, Raimondi S, Pagano K, Relini A, Bucciantini M, Corazza A, Fogolari F, Codutti L, Salmona M, Mangione P, Colombo L, De Luigi A, Porcari R, Gliozzi A, Stefani M, Esposito G, Bellotti V, Stoppini M: Effect of tetracyclines on the dynamics of formation and destructuration of beta2-microglobulin amyloid fibrils. J Biol Chem. 2011 Jan 21;286(3):2121-31. doi: 10.1074/jbc.M110.178376. Epub 2010 Nov 10. [PubMed:21068391 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Zhao XJ, Ishizaki T: A further interaction study of quinine with clinically important drugs by human liver microsomes: determinations of inhibition constant (Ki) and type of inhibition. Eur J Drug Metab Pharmacokinet. 1999 Jul-Sep;24(3):272-8. [PubMed:10716067 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS) (By similarity). Mediates the sodium-in...
Gene Name:
SLC22A6
Uniprot ID:
Q4U2R8
Molecular Weight:
61815.78 Da
References
  1. Babu E, Takeda M, Narikawa S, Kobayashi Y, Yamamoto T, Cha SH, Sekine T, Sakthisekaran D, Endou H: Human organic anion transporters mediate the transport of tetracycline. Jpn J Pharmacol. 2002 Jan;88(1):69-76. [PubMed:11855680 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone-3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA).
Gene Name:
SLC22A8
Uniprot ID:
Q8TCC7
Molecular Weight:
59855.585 Da
References
  1. Babu E, Takeda M, Narikawa S, Kobayashi Y, Yamamoto T, Cha SH, Sekine T, Sakthisekaran D, Endou H: Human organic anion transporters mediate the transport of tetracycline. Jpn J Pharmacol. 2002 Jan;88(1):69-76. [PubMed:11855680 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates saturable uptake of estrone sulfate, dehydroepiandrosterone sulfate and related compounds.
Gene Name:
SLC22A11
Uniprot ID:
Q9NSA0
Molecular Weight:
59970.945 Da
References
  1. Babu E, Takeda M, Narikawa S, Kobayashi Y, Yamamoto T, Cha SH, Sekine T, Sakthisekaran D, Endou H: Human organic anion transporters mediate the transport of tetracycline. Jpn J Pharmacol. 2002 Jan;88(1):69-76. [PubMed:11855680 ]
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Drug created on June 13, 2005 07:24 / Updated on September 29, 2016 02:27