Sulfotransferase 6B1

Details

Name
Sulfotransferase 6B1
Synonyms
  • ST6B1
  • Thyroxine sulfotransferase
Gene Name
SULT6B1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0052144|Sulfotransferase 6B1
MADKSKFIEYIDEALEKSKETALSHLFFTYQGIPYPITMCTSETFQALDTFEARHDDIVL
ASYPKCGSNWILHIVSELIYAVSKKKYKYPEFPVLECGDSEKYQRMKGFPSPRILATHLH
YDKLPGSIFENKAKILVIFRNPKDTAVSFLHFHNDVPDIPSYGSWDEFFRQFMKGQVSWG
RYFDFAINWNKHLDGDNVKFILYEDLKENLAAGIKQIAEFLGFFLTGEQIQTISVQSTFQ
AMRAKSQDTHGAVGPFLFRKGEVGDWKNLFSEIQNQEMDEKFKECLAGTSLGAKLKYESY
CQG
Number of residues
303
Molecular Weight
34918.5
Theoretical pI
Not Available
GO Classification
Functions
sulfotransferase activity
Processes
3'-phosphoadenosine 5'-phosphosulfate metabolic process
Components
cytosol
General Function
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of thyroxine. Involved in the metabolism of thyroxine (By similarity).
Specific Function
Sulfotransferase activity
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0052145|Sulfotransferase 6B1 (SULT6B1)
ATGTGCACCTCAGAAACTTTCCAAGCGCTGGACACCTTCGAAGCCAGACATGATGACATC
GTGCTAGCATCTTATCCAAAGTGCGGTTCAAACTGGATTCTCCACATTGTCAGTGAATTA
ATATATGCTGTTTCTAAAAAAAAGTATAAATATCCAGAATTCCCAGTTCTTGAATGTGGG
GATTCAGAAAAATATCAGAGAATGAAAGGCTTTCCATCACCAAGGATTTTGGCAACTCAC
CTCCACTATGACAAATTACCTGGGTCTATCTTCGAGAATAAAGCCAAGATATTGGTGATA
TTTCGAAACCCTAAAGATACAGCAGTATCTTTTTTGCATTTCCACAACGATGTCCCCGAT
ATTCCAAGCTATGGCTCTTGGGATGAATTCTTCAGACAGTTCATGAAAGGACAAGTTTCT
TGGGGAAGGTATTTTGATTTTGCAATCAATTGGAACAAACATCTTGATGGCGACAATGTT
AAGTTCATATTATATGAAGACCTGAAAGAGAATCTGGCTGCTGGAATAAAACAGATTGCT
GAGTTCTTGGGATTCTTTCTAACTGGGGAGCAAATTCAAACTATCTCAGTCCAGAGCACC
TTCCAAGCCATGCGTGCGAAGTCTCAGGACACACACGGTGCTGTCGGCCCATTCCTTTTC
CGCAAAGGTGAAGTTGGTGATTGGAAAAATTTGTTCAGTGAAATTCAGAACCAGGAAATG
GATGAAAAATTCAAAGAGTGCTTAGCAGGCACCTCCCTCGGAGCAAAGTTGAAGTATGAA
TCATATTGCCAGGGTTGA
Chromosome Location
2
Locus
2p22.2
External Identifiers
ResourceLink
UniProtKB IDQ6IMI4
UniProtKB Entry NameST6B1_HUMAN
HGNC IDHGNC:33433
General References
  1. Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H, Sun H, Bradshaw-Cordum H, Ali J, Carter J, Cordes M, Harris A, Isak A, van Brunt A, Nguyen C, Du F, Courtney L, Kalicki J, Ozersky P, Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M, Cotton M, Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T, Haakenson W, Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid S, Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C, Trani L, Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L, Meyer R, Sabo A, Shotland Y, Sinha P, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD, Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD, Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P, Suyama M, Torrents D, Waterston RH, Wilson RK: Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature. 2005 Apr 7;434(7034):724-31. [Article]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  3. Freimuth RR, Wiepert M, Chute CG, Wieben ED, Weinshilboum RM: Human cytosolic sulfotransferase database mining: identification of seven novel genes and pseudogenes. Pharmacogenomics J. 2004;4(1):54-65. doi: 10.1038/sj.tpj.6500223. [Article]
  4. Takahashi S, Sakakibara Y, Mishiro E, Kouriki H, Nobe R, Kurogi K, Yasuda S, Liu MC, Suiko M: Molecular cloning, expression and characterization of a novel mouse SULT6 cytosolic sulfotransferase. J Biochem. 2009 Sep;146(3):399-405. doi: 10.1093/jb/mvp087. Epub 2009 Jun 8. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00871TerbutalineapprovedunknownsubstrateDetails
DB00960Pindololapproved, investigationalunknownsubstrateDetails
DB00968MethyldopaapprovednosubstrateDetails
DB12471Ibrexafungerpapproved, investigationalunknownsubstrateDetails
DB00867Ritodrineapproved, investigationalnosubstrateDetails
DB12243Edaravoneapproved, investigationalnosubstrateDetails