Up-regulation of transporters of the MRP family by drugs and toxins.
Article Details
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Schrenk D, Baus PR, Ermel N, Klein C, Vorderstemann B, Kauffmann HM
Up-regulation of transporters of the MRP family by drugs and toxins.
Toxicol Lett. 2001 Mar 31;120(1-3):51-7.
- PubMed ID
- 11323161 [ View in PubMed]
- Abstract
Expression of a variety of ABC efflux pumps including certain conjugate transporters of the multidrug resistance protein (MRP) subfamily is inducible in primate and rodent tissues, and in a variety of cell lines and primary cells in culture. In human cell lines (HepG2, MCF-7), we studied the inducibility of MRPs 1-5. Similar to the rat mrp2 gene, human mrp2 is inducible by the chemical carcinogen 2-AAF, the chemotherapeutic drug cisplatin and the barbiturate phenobarbital, as demonstrated in Northern and Western Blots. Furthermore, the antibiotic rifampicin was identified as MRP2 inducer in HepG2 cells. MRP1 and 4 mRNAs being expressed in human liver at a very low level could not be detected in HepG2 cells after treatment with various agents. However, MRP3 and 5 mRNAs were detected in addition to MRP2 and their expression was found to be increased by 2-AAF, cisplatin and rifampicin. MRP1 expression was studied in MCF-7 cells where the chemotherapeutic drug vinblastine and tert-butyl hydroquinone but not the MRP2 inducing agents described above acted as inducers.
DrugBank Data that Cites this Article
- Drug Transporters
Drug Transporter Kind Organism Pharmacological Action Actions Cisplatin Canalicular multispecific organic anion transporter 1 Protein Humans UnknownInducerDetails Cisplatin Canalicular multispecific organic anion transporter 2 Protein Humans UnknownInducerDetails Cisplatin Multidrug resistance-associated protein 5 Protein Humans UnknownInducerDetails Dexamethasone Canalicular multispecific organic anion transporter 1 Protein Humans UnknownInducerDetails Dexamethasone acetate Canalicular multispecific organic anion transporter 1 Protein Humans UnknownInducerDetails Phenobarbital Canalicular multispecific organic anion transporter 1 Protein Humans UnknownInducerDetails Rifampicin Multidrug resistance-associated protein 5 Protein Humans UnknownInducerDetails Vinblastine Canalicular multispecific organic anion transporter 1 Protein Humans UnknownSubstrateInhibitorInducerDetails Vinblastine Multidrug resistance-associated protein 1 Protein Humans UnknownSubstrateInhibitorInducerDetails