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Identification
NameRifampicin
Accession NumberDB01045  (APRD00207, EXPT02777)
TypeSmall Molecule
GroupsApproved
DescriptionA semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)
Structure
Thumb
Synonyms
3-(((4-Methyl-1-piperazinyl)imino)methyl)rifamycin SV
RFP
Rifampicina
Rifampicinum
Rifampin
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
RifadinCapsule150 mgOralSanofi Aventis Canada Inc1995-12-31Not applicableCanada
RifadinCapsule300 mgOralSanofi Aventis Canada Inc1995-12-31Not applicableCanada
RifadinCapsule300 mg/1OralSanofi Aventis U.S. Llc1971-05-21Not applicableUs
Rifadin Cap 300mgCapsule300 mgOralMerrell Dow Pharmaceuticals (Canada) Inc., Division Of Mmdc1988-12-311996-09-09Canada
Rifadin IVInjection, powder, lyophilized, for solution600 mg/10mLIntravenousSanofi Aventis U.S. Llc1989-05-25Not applicableUs
Rofact 150mgCapsule150 mgOralValeant Canada Lp Valeant Canada S.E.C.1977-12-31Not applicableCanada
Rofact 300mgCapsule300 mgOralValeant Canada Lp Valeant Canada S.E.C.1977-12-31Not applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
RifadinCapsule150 mg/1OralSanofi Aventis U.S. Llc1981-07-15Not applicableUs
RifampinCapsule300 mg/1OralREMEDYREPACK INC.2007-04-032016-11-30Us
RifampinCapsule150 mg/1OralREMEDYREPACK INC.2011-06-202016-10-21Us
RifampinInjection, powder, lyophilized, for solution600 mg/10mLIntravenousMylan Institutional LLC2008-05-23Not applicableUs
RifampinInjection, powder, lyophilized, for solution600 mg/1IntravenousWest Ward Pharmaceuticals Corp2016-03-03Not applicableUs
RifampinInjection, powder, lyophilized, for solution600 mg/10mLIntravenousPfizer Laboratories Div Pfizer Inc2011-05-10Not applicableUs
RifampinCapsule, coated300 mg/1OralCardinal Health2001-03-14Not applicableUs
RifampinCapsule150 mg/1OralLupin Pharmaceuticals, Inc.2013-10-28Not applicableUs
RifampinCapsule150 mg/1OralCentral Texas Community Health Centers2001-07-01Not applicableUs
RifampinCapsule, coated300 mg/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
RifampinInjection, powder, lyophilized, for solution600 mg/1IntravenousFresenius Kabi USA, LLC2014-08-21Not applicableUs
RifampinCapsule300 mg/1OralLannett Company, Inc.2008-04-20Not applicableUs
RifampinInjection, powder, lyophilized, for solution600 mg/10mLIntravenousHeritage Pharmaceuticals Inc.2014-08-18Not applicableUs
RifampinCapsule300 mg/1OralA S Medication Solutions2008-04-20Not applicableUs
RifampinCapsule150 mg/1OralREMEDYREPACK INC.2011-08-032016-10-13Us
RifampinCapsule150 mg/1OralAmerican Health Packaging2009-09-25Not applicableUs
RifampinInjection, powder, lyophilized, for solution600 mg/10mLIntravenousPfizer Laboratories Div Pfizer Inc2011-05-10Not applicableUs
RifampinCapsule300 mg/1OralClinical Solutions Wholesale, Llc2008-04-20Not applicableUs
RifampinCapsule300 mg/1OralLupin Pharmaceuticals, Inc.2013-10-28Not applicableUs
RifampinCapsule300 mg/1OralCentral Texas Community Health Centers2001-07-01Not applicableUs
RifampinCapsule300 mg/1OralPhysicians Total Care, Inc.2008-04-20Not applicableUs
RifampinCapsule300 mg/1Oralbryant ranch prepack1997-05-28Not applicableUs
RifampinCapsule150 mg/1OralLannett Company, Inc.2008-04-20Not applicableUs
RifampinCapsule300 mg/1OralRebel Distributors Corp2008-04-20Not applicableUs
RifampinCapsule300 mg/1OralA S Medication Solutions2001-07-01Not applicableUs
RifampinCapsule300 mg/1OralMylan Institutional Inc.1999-12-15Not applicableUs
RifampinCapsule300 mg/1OralAmerican Health Packaging2009-09-25Not applicableUs
RifampinCapsule300 mg/1OralEon Labs, Inc.1997-05-28Not applicableUs
RifampinInjection, powder, lyophilized, for solution600 mg/10mLIntravenousAkorn, Inc.2012-06-01Not applicableUs
RifampinCapsule150 mg/1OralVersa Pharm Incorporated2001-07-01Not applicableUs
RifampinCapsule300 mg/1OralDepartment Of State Health Services, Pharmacy Branch2001-07-01Not applicableUs
RifampinCapsule150 mg/1OralA S Medication Solutions2001-07-01Not applicableUs
RifampinCapsule150 mg/1OralPhysicians Total Care, Inc.2008-04-20Not applicableUs
RifampinCapsule300 mg/1OralREMEDYREPACK INC.2011-03-282016-10-18Us
RifampinCapsule300 mg/1OralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2006-11-30Not applicableUs
RifampinCapsule300 mg/1OralMajor Pharmaceuticals2009-10-07Not applicableUs
RifampinCapsule, coated300 mg/1OralCarilion Materials Management2001-07-01Not applicableUs
RifampinCapsule300 mg/1OralA S Medication Solutions2008-04-20Not applicableUs
RifampinCapsule, coated300 mg/1OralH.J. Harkins Company, Inc.2001-07-01Not applicableUs
RifampinCapsule300 mg/1OralVersa Pharm Incorporated2001-07-01Not applicableUs
RifampinCapsule150 mg/1OralEon Labs, Inc.1998-01-02Not applicableUs
RifampinCapsule300 mg/1OralRebel Distributors Corp1997-05-28Not applicableUs
RifampinCapsule300 mg/1OralCardinal Health2011-05-20Not applicableUs
RifampinCapsule150 mg/1OralDepartment Of State Health Services, Pharmacy Branch2001-07-01Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
RifadineNot Available
RifaldinNot Available
RifoldinNot Available
RimactanNot Available
RimactaneNot Available
RofactNot Available
TubocinNot Available
Brand mixtures
NameLabellerIngredients
IsonarifVersa Pharm Incorporated
RifamateSanofi Aventis U.S. Llc
RifaterREMEDYREPACK INC.
Salts
Name/CASStructureProperties
Rifampicin sodium
ThumbNot applicableDBSALT001014
Categories
UNIIVJT6J7R4TR
CAS number13292-46-1
WeightAverage: 822.9402
Monoisotopic: 822.40512334
Chemical FormulaC43H58N4O12
InChI KeyJQXXHWHPUNPDRT-WLSIYKJHSA-N
InChI
InChI=1S/C43H58N4O12/c1-21-12-11-13-22(2)42(55)45-33-28(20-44-47-17-15-46(9)16-18-47)37(52)30-31(38(33)53)36(51)26(6)40-32(30)41(54)43(8,59-40)57-19-14-29(56-10)23(3)39(58-27(7)48)25(5)35(50)24(4)34(21)49/h11-14,19-21,23-25,29,34-35,39,49-53H,15-18H2,1-10H3,(H,45,55)/b12-11+,19-14+,22-13-,44-20+/t21-,23+,24+,25+,29-,34-,35+,39+,43-/m0/s1
IUPAC Name
(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[(1E)-[(4-methylpiperazin-1-yl)imino]methyl]-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.1⁴,⁷.0⁵,²⁸]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl acetate
SMILES
CO[[email protected]]1\C=C\O[C@@]2(C)OC3=C(C2=O)C2=C(O)C(\C=N\N4CCN(C)CC4)=C(NC(=O)\C(C)=C/C=C/[[email protected]](C)[[email protected]](O)[C@@H](C)[C@@H](O)[C@@H](C)[[email protected]](OC(C)=O)[C@@H]1C)C(O)=C2C(O)=C3C
Pharmacology
IndicationFor the treatment of Tuberculosis and Tuberculosis-related mycobacterial infections.
Structured Indications
PharmacodynamicsRifampin is an antibiotic that inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme. It is bactericidal and has a very broad spectrum of activity against most gram-positive and gram-negative organisms (including Pseudomonas aeruginosa) and specifically Mycobacterium tuberculosis. Because of rapid emergence of resistant bacteria, use is restricted to treatment of mycobacterial infections and a few other indications. Rifampin is well absorbed when taken orally and is distributed widely in body tissues and fluids, including the CSF. It is metabolized in the liver and eliminated in bile and, to a much lesser extent, in urine, but dose adjustments are unnecessary with renal insufficiency.
Mechanism of actionRifampin acts via the inhibition of DNA-dependent RNA polymerase, leading to a suppression of RNA synthesis and cell death.
TargetKindPharmacological actionActionsOrganismUniProt ID
DNA-directed RNA polymerase subunit betaProteinyes
inhibitor
Escherichia coli (strain K12)P0A8V2 details
DNA-directed RNA polymerase subunit beta'Proteinyes
inhibitor
Escherichia coli (strain K12)P0A8T7 details
Nuclear receptor subfamily 1 group I member 2Proteinunknown
agonist
HumanO75469 details
Solute carrier organic anion transporter family member 1B1ProteinunknownNot AvailableHumanQ9Y6L6 details
Solute carrier organic anion transporter family member 1A2ProteinunknownNot AvailableHumanP46721 details
Solute carrier organic anion transporter family member 1B3ProteinunknownNot AvailableHumanQ9NPD5 details
Lanosterol 14-alpha demethylaseProteinunknownNot AvailableHumanQ16850 details
Serum albuminProteinunknownNot AvailableHumanP02768 details
Solute carrier organic anion transporter family member 2B1ProteinunknownNot AvailableHumanO94956 details
Related Articles
AbsorptionWell absorbed from gastrointestinal tract.
Volume of distributionNot Available
Protein binding89%
Metabolism

Primarily hepatic, rapidly deacetylated.

Route of eliminationLess than 30% of the dose is excreted in the urine as rifampin or metabolites.
Half life3.35 (+/- 0.66) hours
Clearance
  • 0.19 +/- 0.06 L/hr/kg [300 mg IV]
  • 0.14 +/- 0.03 L/hr/kg [600 mg IV]
ToxicityLD50=1570 mg/kg (rat), chronic exposure may cause nausea and vomiting and unconsciousness
Affected organisms
  • Mycobacteria
  • Mycobacterium tuberculosis
  • Various gram-negative and gram-positive eubacteria
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
16-BromoepiandrosteroneThe serum concentration of 16-Bromoepiandrosterone can be decreased when it is combined with Rifampicin.Investigational
19-norandrostenedioneThe serum concentration of 19-norandrostenedione can be decreased when it is combined with Rifampicin.Experimental, Illicit
2-HYDROXY-1,4-NAPHTHOQUINONEThe serum concentration of Rifampicin can be increased when it is combined with 2-HYDROXY-1,4-NAPHTHOQUINONE.Experimental
2-mercaptobenzothiazoleThe serum concentration of Rifampicin can be increased when it is combined with 2-mercaptobenzothiazole.Vet Approved
4-AndrostenedioneThe serum concentration of 4-Androstenedione can be decreased when it is combined with Rifampicin.Experimental, Illicit
5-androstenedioneThe serum concentration of 5-androstenedione can be decreased when it is combined with Rifampicin.Experimental, Illicit
AbirateroneThe serum concentration of Abiraterone can be decreased when it is combined with Rifampicin.Approved
AcebutololThe serum concentration of Acebutolol can be decreased when it is combined with Rifampicin.Approved
AceclofenacThe metabolism of Aceclofenac can be increased when combined with Rifampicin.Approved
AcenocoumarolThe metabolism of Acenocoumarol can be increased when combined with Rifampicin.Approved
AcetaminophenThe metabolism of Acetaminophen can be increased when combined with Rifampicin.Approved
AcetohexamideThe serum concentration of Acetohexamide can be decreased when it is combined with Rifampicin.Withdrawn
Acetylsalicylic acidThe metabolism of Acetylsalicylic acid can be increased when combined with Rifampicin.Approved, Vet Approved
AdinazolamThe metabolism of Adinazolam can be increased when combined with Rifampicin.Approved
AfatinibThe serum concentration of Afatinib can be decreased when it is combined with Rifampicin.Approved
AlbendazoleThe metabolism of Albendazole can be increased when combined with Rifampicin.Approved, Vet Approved
AlclometasoneThe metabolism of Alclometasone can be increased when combined with Rifampicin.Approved
AldosteroneThe serum concentration of Aldosterone can be decreased when it is combined with Rifampicin.Experimental
AlectinibThe serum concentration of Rifampicin can be increased when it is combined with Alectinib.Approved
AlfentanilThe serum concentration of Alfentanil can be decreased when it is combined with Rifampicin.Approved, Illicit
AlfuzosinThe metabolism of Alfuzosin can be increased when combined with Rifampicin.Approved, Investigational
AliskirenThe metabolism of Aliskiren can be increased when combined with Rifampicin.Approved, Investigational
AlitretinoinThe serum concentration of Alitretinoin can be decreased when it is combined with Rifampicin.Approved, Investigational
AllylestrenolThe metabolism of Allylestrenol can be increased when combined with Rifampicin.Approved
AlmotriptanThe metabolism of Almotriptan can be increased when combined with Rifampicin.Approved, Investigational
AlogliptinThe metabolism of Alogliptin can be increased when combined with Rifampicin.Approved
AlosetronThe metabolism of Alosetron can be increased when combined with Rifampicin.Approved, Withdrawn
AlprazolamThe metabolism of Alprazolam can be increased when combined with Rifampicin.Approved, Illicit, Investigational
AlprenololThe serum concentration of Alprenolol can be decreased when it is combined with Rifampicin.Approved, Withdrawn
AmantadineThe serum concentration of Rifampicin can be increased when it is combined with Amantadine.Approved
AmbrisentanThe metabolism of Ambrisentan can be increased when combined with Rifampicin.Approved, Investigational
AmbroxolThe metabolism of Ambroxol can be increased when combined with Rifampicin.Approved
AmcinonideThe serum concentration of Amcinonide can be decreased when it is combined with Rifampicin.Approved
Aminohippuric acidThe serum concentration of Rifampicin can be increased when it is combined with Aminohippuric acid.Approved
AminophenazoneThe metabolism of Aminophenazone can be increased when combined with Rifampicin.Approved, Withdrawn
AminophyllineThe metabolism of Aminophylline can be increased when combined with Rifampicin.Approved
AmiodaroneThe serum concentration of the active metabolites of Amiodarone can be reduced when Amiodarone is used in combination with Rifampicin resulting in a loss in efficacy.Approved, Investigational
AmitriptylineThe metabolism of Amitriptyline can be increased when combined with Rifampicin.Approved
AmlodipineThe metabolism of Amlodipine can be increased when combined with Rifampicin.Approved
AmobarbitalThe metabolism of Amobarbital can be increased when combined with Rifampicin.Approved, Illicit
AmodiaquineThe serum concentration of Amodiaquine can be increased when it is combined with Rifampicin.Approved
AmorolfineThe serum concentration of Rifampicin can be increased when it is combined with Amorolfine.Approved
AmoxicillinThe metabolism of Amoxicillin can be increased when combined with Rifampicin.Approved, Vet Approved
Amphotericin BThe serum concentration of Rifampicin can be increased when it is combined with Amphotericin B.Approved, Investigational
AmprenavirThe metabolism of Amprenavir can be increased when combined with Rifampicin.Approved
AmrinoneThe serum concentration of Amrinone can be decreased when it is combined with Rifampicin.Approved
AmsacrineThe serum concentration of Rifampicin can be increased when it is combined with Amsacrine.Approved
AN2690The serum concentration of Rifampicin can be increased when it is combined with AN2690.Investigational
AnagrelideThe metabolism of Anagrelide can be increased when combined with Rifampicin.Approved
AnecortaveThe serum concentration of Anecortave can be decreased when it is combined with Rifampicin.Investigational
AnidulafunginThe serum concentration of Rifampicin can be increased when it is combined with Anidulafungin.Approved, Investigational
AntipyrineThe metabolism of Antipyrine can be increased when combined with Rifampicin.Approved
Aop200704The serum concentration of Aop200704 can be decreased when it is combined with Rifampicin.Investigational
ApixabanThe serum concentration of Apixaban can be decreased when it is combined with Rifampicin.Approved
ApremilastThe serum concentration of Apremilast can be decreased when it is combined with Rifampicin.Approved, Investigational
AprepitantThe serum concentration of Aprepitant can be decreased when it is combined with Rifampicin.Approved, Investigational
Arachidonic AcidThe metabolism of Arachidonic Acid can be increased when combined with Rifampicin.Experimental
ArformoterolThe metabolism of Arformoterol can be increased when combined with Rifampicin.Approved, Investigational
ArgatrobanThe metabolism of Argatroban can be increased when combined with Rifampicin.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be decreased when it is combined with Rifampicin.Approved, Investigational
ArotinololThe serum concentration of Arotinolol can be decreased when it is combined with Rifampicin.Approved
Arsenic trioxideThe serum concentration of Arsenic trioxide can be decreased when it is combined with Rifampicin.Approved, Investigational
ArtemetherThe serum concentration of the active metabolites of Artemether can be reduced when Artemether is used in combination with Rifampicin resulting in a loss in efficacy.Approved
ArtesunateThe serum concentration of the active metabolites of Artesunate can be reduced when Artesunate is used in combination with Rifampicin resulting in a loss in efficacy.Approved
ASA404The metabolism of ASA404 can be increased when combined with Rifampicin.Investigational
AsenapineThe metabolism of Asenapine can be increased when combined with Rifampicin.Approved
AstemizoleThe metabolism of Astemizole can be increased when combined with Rifampicin.Approved, Withdrawn
AtazanavirThe serum concentration of Atazanavir can be decreased when it is combined with Rifampicin.Approved, Investigational
AtenololThe serum concentration of Atenolol can be decreased when it is combined with Rifampicin.Approved
AtomoxetineThe metabolism of Atomoxetine can be increased when combined with Rifampicin.Approved
AtorvastatinThe metabolism of Atorvastatin can be increased when combined with Rifampicin.Approved
AtovaquoneThe serum concentration of Atovaquone can be decreased when it is combined with Rifampicin.Approved
AV650The metabolism of AV650 can be increased when combined with Rifampicin.Approved, Investigational
AvanafilThe metabolism of Avanafil can be increased when combined with Rifampicin.Approved
AxitinibThe serum concentration of Axitinib can be decreased when it is combined with Rifampicin.Approved, Investigational
AzelastineThe metabolism of Azelastine can be increased when combined with Rifampicin.Approved
AzelnidipineThe serum concentration of Azelnidipine can be decreased when it is combined with Rifampicin.Approved
AzimilideThe serum concentration of Azimilide can be decreased when it is combined with Rifampicin.Investigational
AzithromycinThe metabolism of Azithromycin can be increased when combined with Rifampicin.Approved
Bafilomycin A1The serum concentration of Rifampicin can be increased when it is combined with Bafilomycin A1.Experimental
BanoxantroneThe metabolism of Banoxantrone can be increased when combined with Rifampicin.Investigational
BarbexacloneThe metabolism of Barbexaclone can be increased when combined with Rifampicin.Experimental
BarbitalThe metabolism of Barbital can be increased when combined with Rifampicin.Illicit
BarnidipineThe serum concentration of Barnidipine can be decreased when it is combined with Rifampicin.Approved
BazedoxifeneThe serum concentration of Bazedoxifene can be decreased when it is combined with Rifampicin.Approved, Investigational
BcgThe therapeutic efficacy of Bcg can be decreased when used in combination with Rifampicin.Investigational
BeclomethasoneThe serum concentration of Beclomethasone can be decreased when it is combined with Rifampicin.Investigational
Beclomethasone dipropionateThe serum concentration of Beclomethasone dipropionate can be decreased when it is combined with Rifampicin.Approved, Investigational
BedaquilineThe serum concentration of Bedaquiline can be decreased when it is combined with Rifampicin.Approved
BefunololThe serum concentration of Befunolol can be decreased when it is combined with Rifampicin.Experimental
BendamustineThe serum concentration of Bendamustine can be decreased when it is combined with Rifampicin.Approved, Investigational
BenidipineThe serum concentration of Benidipine can be decreased when it is combined with Rifampicin.Approved
BenzatropineThe metabolism of Benzatropine can be increased when combined with Rifampicin.Approved
BenzocaineThe serum concentration of Rifampicin can be increased when it is combined with Benzocaine.Approved
Benzoic AcidThe serum concentration of Rifampicin can be increased when it is combined with Benzoic Acid.Approved
BenzphetamineThe metabolism of Benzphetamine can be increased when combined with Rifampicin.Approved, Illicit
Benzyl alcoholThe metabolism of Benzyl alcohol can be increased when combined with Rifampicin.Approved
BepridilThe serum concentration of Bepridil can be decreased when it is combined with Rifampicin.Approved, Withdrawn
BeraprostThe metabolism of Beraprost can be increased when combined with Rifampicin.Investigational
BetamethasoneThe serum concentration of Betamethasone can be decreased when it is combined with Rifampicin.Approved, Vet Approved
BetaxololThe metabolism of Betaxolol can be increased when combined with Rifampicin.Approved
BevantololThe serum concentration of Bevantolol can be decreased when it is combined with Rifampicin.Approved
BexaroteneThe metabolism of Bexarotene can be increased when combined with Rifampicin.Approved, Investigational
BezafibrateThe metabolism of Bezafibrate can be increased when combined with Rifampicin.Approved
BicalutamideThe metabolism of Bicalutamide can be increased when combined with Rifampicin.Approved
BifonazoleThe serum concentration of Rifampicin can be increased when it is combined with Bifonazole.Approved
BiperidenThe serum concentration of Rifampicin can be increased when it is combined with Biperiden.Approved
BisoprololThe metabolism of Bisoprolol can be increased when combined with Rifampicin.Approved
BoceprevirThe serum concentration of Boceprevir can be decreased when it is combined with Rifampicin.Approved
BopindololThe serum concentration of Bopindolol can be decreased when it is combined with Rifampicin.Approved
BortezomibThe serum concentration of Bortezomib can be decreased when it is combined with Rifampicin.Approved, Investigational
BosentanThe serum concentration of Bosentan can be decreased when it is combined with Rifampicin.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be decreased when it is combined with Rifampicin.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be decreased when it is combined with Rifampicin.Approved
BrexpiprazoleThe serum concentration of Brexpiprazole can be decreased when it is combined with Rifampicin.Approved
BrinzolamideThe metabolism of Brinzolamide can be increased when combined with Rifampicin.Approved
BromazepamThe metabolism of Bromazepam can be increased when combined with Rifampicin.Approved, Illicit
BromocriptineThe metabolism of Bromocriptine can be increased when combined with Rifampicin.Approved, Investigational
BrompheniramineThe metabolism of Brompheniramine can be increased when combined with Rifampicin.Approved
BucindololThe serum concentration of Bucindolol can be decreased when it is combined with Rifampicin.Investigational
BudesonideThe metabolism of Budesonide can be increased when combined with Rifampicin.Approved
BufuralolThe serum concentration of Bufuralol can be decreased when it is combined with Rifampicin.Experimental, Investigational
BupivacaineThe metabolism of Bupivacaine can be increased when combined with Rifampicin.Approved, Investigational
BupranololThe serum concentration of Bupranolol can be decreased when it is combined with Rifampicin.Approved
BuprenorphineThe metabolism of Buprenorphine can be increased when combined with Rifampicin.Approved, Illicit, Investigational, Vet Approved
BupropionThe metabolism of Bupropion can be increased when combined with Rifampicin.Approved
BuspironeThe serum concentration of Buspirone can be decreased when it is combined with Rifampicin.Approved, Investigational
BusulfanThe metabolism of Busulfan can be increased when combined with Rifampicin.Approved, Investigational
ButenafineThe serum concentration of Rifampicin can be increased when it is combined with Butenafine.Approved
ButoconazoleThe serum concentration of Rifampicin can be increased when it is combined with Butoconazole.Approved
CabazitaxelThe metabolism of Cabazitaxel can be increased when combined with Rifampicin.Approved
CabergolineThe metabolism of Cabergoline can be increased when combined with Rifampicin.Approved
CabozantinibThe serum concentration of Cabozantinib can be decreased when it is combined with Rifampicin.Approved
CaffeineThe metabolism of Caffeine can be increased when combined with Rifampicin.Approved
CaiThe serum concentration of Cai can be decreased when it is combined with Rifampicin.Investigational
CalcitriolThe metabolism of Calcitriol can be increased when combined with Rifampicin.Approved, Nutraceutical
CamptothecinThe serum concentration of Camptothecin can be decreased when it is combined with Rifampicin.Experimental
CanagliflozinThe serum concentration of Canagliflozin can be decreased when it is combined with Rifampicin.Approved
CandesartanThe metabolism of Candesartan can be increased when combined with Rifampicin.Approved
CandicidinThe serum concentration of Rifampicin can be increased when it is combined with Candicidin.Withdrawn
CannabidiolThe serum concentration of Cannabidiol can be decreased when it is combined with Rifampicin.Approved, Investigational
CapecitabineThe metabolism of Rifampicin can be decreased when combined with Capecitabine.Approved, Investigational
CaptoprilThe serum concentration of Rifampicin can be increased when it is combined with Captopril.Approved
CarbamazepineThe metabolism of Rifampicin can be increased when combined with Carbamazepine.Approved, Investigational
CarbinoxamineThe metabolism of Carbinoxamine can be increased when combined with Rifampicin.Approved
CarbomycinThe metabolism of Rifampicin can be decreased when combined with Carbomycin.Vet Approved
CarfilzomibThe serum concentration of Carfilzomib can be decreased when it is combined with Rifampicin.Approved
CariprazineThe metabolism of Cariprazine can be increased when combined with Rifampicin.Approved
CarisoprodolThe metabolism of Carisoprodol can be increased when combined with Rifampicin.Approved
CarmustineThe metabolism of Carmustine can be increased when combined with Rifampicin.Approved
CarteololThe serum concentration of Carteolol can be decreased when it is combined with Rifampicin.Approved
CarvedilolThe metabolism of Carvedilol can be increased when combined with Rifampicin.Approved, Investigational
CaspofunginThe serum concentration of Caspofungin can be decreased when it is combined with Rifampicin.Approved
CelecoxibThe metabolism of Celecoxib can be increased when combined with Rifampicin.Approved, Investigational
CeliprololThe metabolism of Celiprolol can be increased when combined with Rifampicin.Approved, Investigational
CephalexinThe metabolism of Cephalexin can be increased when combined with Rifampicin.Approved, Vet Approved
CeritinibThe serum concentration of Ceritinib can be decreased when it is combined with Rifampicin.Approved
CerivastatinThe metabolism of Cerivastatin can be increased when combined with Rifampicin.Withdrawn
CeruleninThe serum concentration of Rifampicin can be increased when it is combined with Cerulenin.Approved
CevimelineThe metabolism of Cevimeline can be increased when combined with Rifampicin.Approved
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be increased when combined with Rifampicin.Approved
ChloramphenicolThe metabolism of Chloramphenicol can be increased when combined with Rifampicin.Approved, Vet Approved
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be increased when combined with Rifampicin.Approved, Illicit
ChloroquineThe metabolism of Chloroquine can be increased when combined with Rifampicin.Approved, Vet Approved
ChlorotrianiseneThe serum concentration of Chlorotrianisene can be decreased when it is combined with Rifampicin.Withdrawn
ChloroxineThe serum concentration of Rifampicin can be increased when it is combined with Chloroxine.Approved
ChlorphenamineThe metabolism of Chlorphenamine can be increased when combined with Rifampicin.Approved
ChlorpromazineThe metabolism of Chlorpromazine can be increased when combined with Rifampicin.Approved, Vet Approved
ChlorpropamideThe serum concentration of Chlorpropamide can be decreased when it is combined with Rifampicin.Approved
ChlorprothixeneThe serum concentration of Rifampicin can be increased when it is combined with Chlorprothixene.Approved, Withdrawn
ChlorzoxazoneThe metabolism of Chlorzoxazone can be increased when combined with Rifampicin.Approved
CholecalciferolThe metabolism of Cholecalciferol can be increased when combined with Rifampicin.Approved, Nutraceutical
CholesterolThe serum concentration of Rifampicin can be increased when it is combined with Cholesterol.Experimental
Cholic AcidRifampicin may decrease the excretion rate of Cholic Acid which could result in a higher serum level.Approved
CiclesonideThe metabolism of Ciclesonide can be increased when combined with Rifampicin.Approved, Investigational
CiclopiroxThe serum concentration of Rifampicin can be increased when it is combined with Ciclopirox.Approved, Investigational
CilazaprilThe serum concentration of Rifampicin can be increased when it is combined with Cilazapril.Approved
CilnidipineThe serum concentration of Cilnidipine can be decreased when it is combined with Rifampicin.Approved
CilostazolThe metabolism of Cilostazol can be increased when combined with Rifampicin.Approved
CimetidineThe serum concentration of Cimetidine can be decreased when it is combined with Rifampicin.Approved
CinacalcetThe metabolism of Cinacalcet can be increased when combined with Rifampicin.Approved
CinnarizineThe metabolism of Cinnarizine can be increased when combined with Rifampicin.Approved
CiprofloxacinThe serum concentration of Ciprofloxacin can be decreased when it is combined with Rifampicin.Approved, Investigational
CisaprideThe metabolism of Cisapride can be increased when combined with Rifampicin.Approved, Investigational, Withdrawn
CisplatinThe serum concentration of Cisplatin can be decreased when it is combined with Rifampicin.Approved
CitalopramThe serum concentration of Citalopram can be decreased when it is combined with Rifampicin.Approved
ClarithromycinThe serum concentration of the active metabolites of Clarithromycin can be increased when Clarithromycin is used in combination with Rifampicin.Approved
ClemastineThe metabolism of Rifampicin can be decreased when combined with Clemastine.Approved
ClenbuterolThe metabolism of Clenbuterol can be increased when combined with Rifampicin.Approved, Vet Approved
ClevidipineThe metabolism of Clevidipine can be increased when combined with Rifampicin.Approved
ClindamycinThe metabolism of Clindamycin can be increased when combined with Rifampicin.Approved, Vet Approved
ClobazamThe metabolism of Clobazam can be increased when combined with Rifampicin.Approved, Illicit
ClobetasolThe serum concentration of Clobetasol can be decreased when it is combined with Rifampicin.Investigational
Clobetasol propionateThe serum concentration of Clobetasol propionate can be decreased when it is combined with Rifampicin.Approved
ClocortoloneThe serum concentration of Clocortolone can be decreased when it is combined with Rifampicin.Approved
ClofazimineThe metabolism of Clofazimine can be increased when combined with Rifampicin.Approved, Investigational
ClofibrateThe metabolism of Clofibrate can be increased when combined with Rifampicin.Approved
clomethiazoleThe metabolism of clomethiazole can be increased when combined with Rifampicin.Investigational
ClomifeneThe serum concentration of Clomifene can be decreased when it is combined with Rifampicin.Approved, Investigational
ClomipramineThe metabolism of Clomipramine can be increased when combined with Rifampicin.Approved, Vet Approved
ClonazepamThe metabolism of Clonazepam can be increased when combined with Rifampicin.Approved, Illicit
ClonidineThe metabolism of Clonidine can be increased when combined with Rifampicin.Approved
ClopidogrelThe risk or severity of adverse effects can be increased when Rifampicin is combined with Clopidogrel.Approved, Nutraceutical
ClorazepateThe metabolism of Clorazepate can be increased when combined with Rifampicin.Approved, Illicit
ClotiazepamThe metabolism of Clotiazepam can be increased when combined with Rifampicin.Approved, Illicit
ClotrimazoleThe serum concentration of Rifampicin can be increased when it is combined with Clotrimazole.Approved, Vet Approved
ClozapineThe serum concentration of Clozapine can be decreased when it is combined with Rifampicin.Approved
CobicistatThe serum concentration of Cobicistat can be decreased when it is combined with Rifampicin.Approved
CobimetinibThe serum concentration of Cobimetinib can be decreased when it is combined with Rifampicin.Approved
CocaineThe metabolism of Cocaine can be increased when combined with Rifampicin.Approved, Illicit
CodeineThe metabolism of Codeine can be increased when combined with Rifampicin.Approved, Illicit
Coenzyme Q10The serum concentration of Coenzyme Q10 can be decreased when it is combined with Rifampicin.Experimental
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Rifampicin.Approved
ColforsinThe serum concentration of Rifampicin can be increased when it is combined with Colforsin.Experimental
ConivaptanThe serum concentration of Rifampicin can be increased when it is combined with Conivaptan.Approved, Investigational
Conjugated Equine EstrogensThe metabolism of Conjugated Equine Estrogens can be increased when combined with Rifampicin.Approved
CordycepinThe serum concentration of Rifampicin can be increased when it is combined with Cordycepin.Investigational
Cortisone acetateThe metabolism of Cortisone acetate can be increased when combined with Rifampicin.Approved
CrizotinibThe serum concentration of Crizotinib can be decreased when it is combined with Rifampicin.Approved
CyclobenzaprineThe metabolism of Cyclobenzaprine can be increased when combined with Rifampicin.Approved
CyclophosphamideThe metabolism of Cyclophosphamide can be increased when combined with Rifampicin.Approved, Investigational
CyclosporineThe metabolism of Cyclosporine can be increased when combined with Rifampicin.Approved, Investigational, Vet Approved
CytarabineThe metabolism of Cytarabine can be increased when combined with Rifampicin.Approved, Investigational
Dabigatran etexilateThe serum concentration of Dabigatran etexilate can be decreased when it is combined with Rifampicin.Approved
DabrafenibThe serum concentration of Rifampicin can be decreased when it is combined with Dabrafenib.Approved
DacarbazineThe metabolism of Dacarbazine can be increased when combined with Rifampicin.Approved, Investigational
DaclatasvirThe serum concentration of Daclatasvir can be decreased when it is combined with Rifampicin.Approved
DactinomycinThe serum concentration of Dactinomycin can be decreased when it is combined with Rifampicin.Approved
DantroleneThe metabolism of Dantrolene can be increased when combined with Rifampicin.Approved
DapagliflozinThe metabolism of Dapagliflozin can be increased when combined with Rifampicin.Approved
DapsoneThe metabolism of Dapsone can be increased when combined with Rifampicin.Approved, Investigational
DarifenacinThe metabolism of Darifenacin can be increased when combined with Rifampicin.Approved, Investigational
DarodipineThe serum concentration of Darodipine can be decreased when it is combined with Rifampicin.Experimental
DarunavirThe serum concentration of Darunavir can be decreased when it is combined with Rifampicin.Approved
DasabuvirThe serum concentration of Dasabuvir can be decreased when it is combined with Rifampicin.Approved
DasatinibThe serum concentration of Dasatinib can be decreased when it is combined with Rifampicin.Approved, Investigational
DaunorubicinThe metabolism of Daunorubicin can be increased when combined with Rifampicin.Approved
DebrisoquinThe serum concentration of Debrisoquin can be decreased when it is combined with Rifampicin.Approved
Decanoic AcidThe serum concentration of Rifampicin can be increased when it is combined with Decanoic Acid.Experimental
DeferasiroxThe serum concentration of Deferasirox can be decreased when it is combined with Rifampicin.Approved, Investigational
dehydroepiandrosterone sulfateThe serum concentration of dehydroepiandrosterone sulfate can be decreased when it is combined with Rifampicin.Investigational
DelavirdineThe metabolism of Delavirdine can be increased when combined with Rifampicin.Approved
DesipramineThe metabolism of Desipramine can be increased when combined with Rifampicin.Approved
DesloratadineThe serum concentration of Rifampicin can be increased when it is combined with Desloratadine.Approved, Investigational
DesogestrelThe serum concentration of Desogestrel can be decreased when it is combined with Rifampicin.Approved
DesoximetasoneThe serum concentration of Desoximetasone can be decreased when it is combined with Rifampicin.Approved
Desoxycorticosterone acetateThe serum concentration of Desoxycorticosterone acetate can be decreased when it is combined with Rifampicin.Approved
Desoxycorticosterone PivalateThe serum concentration of Desoxycorticosterone Pivalate can be decreased when it is combined with Rifampicin.Experimental, Vet Approved
DesvenlafaxineThe metabolism of Desvenlafaxine can be increased when combined with Rifampicin.Approved
DexamethasoneThe serum concentration of Dexamethasone can be decreased when it is combined with Rifampicin.Approved, Investigational, Vet Approved
DexamethasoneThe metabolism of Dexamethasone can be increased when combined with Rifampicin.Approved, Investigational, Vet Approved
Dexamethasone isonicotinateThe serum concentration of Dexamethasone isonicotinate can be decreased when it is combined with Rifampicin.Vet Approved
DexfenfluramineThe metabolism of Dexfenfluramine can be increased when combined with Rifampicin.Approved, Illicit, Withdrawn
DextromethorphanThe metabolism of Dextromethorphan can be increased when combined with Rifampicin.Approved
DextropropoxypheneThe metabolism of Dextropropoxyphene can be increased when combined with Rifampicin.Approved, Illicit, Withdrawn
DiazepamThe metabolism of Diazepam can be increased when combined with Rifampicin.Approved, Illicit, Vet Approved
DiclofenacThe metabolism of Diclofenac can be increased when combined with Rifampicin.Approved, Vet Approved
DiclofenacThe serum concentration of Diclofenac can be decreased when it is combined with Rifampicin.Approved, Vet Approved
DicoumarolThe metabolism of Dicoumarol can be increased when combined with Rifampicin.Approved
DienestrolThe serum concentration of Dienestrol can be decreased when it is combined with Rifampicin.Approved
DienogestThe serum concentration of Dienogest can be decreased when it is combined with Rifampicin.Approved
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be decreased when it is combined with Rifampicin.Approved
DiflorasoneThe serum concentration of Diflorasone can be decreased when it is combined with Rifampicin.Approved
DifluocortoloneThe serum concentration of Difluocortolone can be decreased when it is combined with Rifampicin.Approved
DifluprednateThe serum concentration of Difluprednate can be decreased when it is combined with Rifampicin.Approved
DigitoxinThe metabolism of Digitoxin can be increased when combined with Rifampicin.Approved
DigoxinThe metabolism of Digoxin can be increased when combined with Rifampicin.Approved
DihydrocodeineThe metabolism of Dihydrocodeine can be increased when combined with Rifampicin.Approved, Illicit
DihydroergotamineThe metabolism of Dihydroergotamine can be increased when combined with Rifampicin.Approved
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Rifampicin.Illicit
DiltiazemThe serum concentration of Diltiazem can be decreased when it is combined with Rifampicin.Approved
DinoprostoneThe metabolism of Dinoprostone can be increased when combined with Rifampicin.Approved
DiphenhydramineThe metabolism of Diphenhydramine can be increased when combined with Rifampicin.Approved
DipyridamoleThe serum concentration of Dipyridamole can be decreased when it is combined with Rifampicin.Approved
DisopyramideThe serum concentration of Disopyramide can be decreased when it is combined with Rifampicin.Approved
DisulfiramThe metabolism of Disulfiram can be increased when combined with Rifampicin.Approved
DocetaxelThe metabolism of Docetaxel can be increased when combined with Rifampicin.Approved, Investigational
DofetilideThe metabolism of Dofetilide can be increased when combined with Rifampicin.Approved
DolasetronThe metabolism of Dolasetron can be increased when combined with Rifampicin.Approved
DolutegravirThe serum concentration of Dolutegravir can be decreased when it is combined with Rifampicin.Approved
DomperidoneThe metabolism of Domperidone can be increased when combined with Rifampicin.Approved, Investigational, Vet Approved
DonepezilThe metabolism of Donepezil can be increased when combined with Rifampicin.Approved
DopamineThe metabolism of Dopamine can be increased when combined with Rifampicin.Approved
DorzolamideThe metabolism of Dorzolamide can be increased when combined with Rifampicin.Approved
DotarizineThe serum concentration of Dotarizine can be decreased when it is combined with Rifampicin.Investigational
DoxazosinThe metabolism of Doxazosin can be increased when combined with Rifampicin.Approved
DoxepinThe metabolism of Doxepin can be increased when combined with Rifampicin.Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Rifampicin.Approved, Investigational
DoxorubicinThe metabolism of Doxorubicin can be increased when combined with Rifampicin.Approved, Investigational
DoxycyclineThe serum concentration of Doxycycline can be decreased when it is combined with Rifampicin.Approved, Investigational, Vet Approved
DronabinolThe serum concentration of Dronabinol can be decreased when it is combined with Rifampicin.Approved, Illicit
DronedaroneThe serum concentration of Dronedarone can be decreased when it is combined with Rifampicin.Approved
DrospirenoneThe serum concentration of Drospirenone can be decreased when it is combined with Rifampicin.Approved
DuloxetineThe metabolism of Duloxetine can be increased when combined with Rifampicin.Approved
DutasterideThe metabolism of Dutasteride can be increased when combined with Rifampicin.Approved, Investigational
EconazoleThe serum concentration of Rifampicin can be increased when it is combined with Econazole.Approved
EdoxabanThe serum concentration of Edoxaban can be decreased when it is combined with Rifampicin.Approved
EfavirenzThe serum concentration of Efavirenz can be decreased when it is combined with Rifampicin.Approved, Investigational
EfinaconazoleThe serum concentration of Rifampicin can be increased when it is combined with Efinaconazole.Approved
EfonidipineThe serum concentration of Efonidipine can be decreased when it is combined with Rifampicin.Approved
ElbasvirThe serum concentration of Rifampicin can be increased when it is combined with Elbasvir.Approved
EletriptanThe metabolism of Eletriptan can be increased when combined with Rifampicin.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be decreased when it is combined with Rifampicin.Approved
EltrombopagThe metabolism of Eltrombopag can be increased when combined with Rifampicin.Approved
EluxadolineThe serum concentration of Eluxadoline can be increased when it is combined with Rifampicin.Approved
ElvitegravirThe serum concentration of Elvitegravir can be decreased when it is combined with Rifampicin.Approved
EnalaprilThe metabolism of Enalapril can be increased when combined with Rifampicin.Approved, Vet Approved
EnfuvirtideThe metabolism of Enfuvirtide can be increased when combined with Rifampicin.Approved, Investigational
EnzalutamideThe serum concentration of Enzalutamide can be decreased when it is combined with Rifampicin.Approved
EperisoneThe serum concentration of Eperisone can be decreased when it is combined with Rifampicin.Approved, Investigational
EpinastineThe metabolism of Epinastine can be increased when combined with Rifampicin.Approved, Investigational
EplerenoneThe metabolism of Eplerenone can be increased when combined with Rifampicin.Approved
EpoprostenolThe metabolism of Epoprostenol can be increased when combined with Rifampicin.Approved
EquileninThe serum concentration of Equilenin can be decreased when it is combined with Rifampicin.Experimental
EquilinThe serum concentration of Equilin can be decreased when it is combined with Rifampicin.Approved
ErgocalciferolThe metabolism of Ergocalciferol can be increased when combined with Rifampicin.Approved, Nutraceutical
Ergoloid mesylateThe metabolism of Ergoloid mesylate can be increased when combined with Rifampicin.Approved
ErgonovineThe metabolism of Ergonovine can be increased when combined with Rifampicin.Approved
ErgotamineThe metabolism of Ergotamine can be increased when combined with Rifampicin.Approved
ErlotinibThe serum concentration of Erlotinib can be decreased when it is combined with Rifampicin.Approved, Investigational
ErythromycinThe metabolism of Erythromycin can be increased when combined with Rifampicin.Approved, Vet Approved
EscitalopramThe metabolism of Escitalopram can be increased when combined with Rifampicin.Approved, Investigational
Eslicarbazepine acetateThe serum concentration of Rifampicin can be decreased when it is combined with Eslicarbazepine acetate.Approved
EsmololThe serum concentration of Esmolol can be decreased when it is combined with Rifampicin.Approved
EsomeprazoleThe serum concentration of Esomeprazole can be decreased when it is combined with Rifampicin.Approved, Investigational
EstazolamThe metabolism of Estazolam can be increased when combined with Rifampicin.Approved, Illicit
EstradiolThe metabolism of Estradiol can be increased when combined with Rifampicin.Approved, Investigational, Vet Approved
Estradiol valerate/DienogestThe metabolism of Estradiol valerate/Dienogest can be increased when combined with Rifampicin.Approved
EstramustineThe metabolism of Estramustine can be increased when combined with Rifampicin.Approved
EstriolThe serum concentration of Estriol can be decreased when it is combined with Rifampicin.Approved, Vet Approved
Estrogens, esterifiedThe serum concentration of Estrogens, esterified can be decreased when it is combined with Rifampicin.Approved
EstroneThe metabolism of Estrone can be increased when combined with Rifampicin.Approved
Estrone sulfateThe metabolism of Estrone sulfate can be increased when combined with Rifampicin.Approved
EszopicloneThe metabolism of Eszopiclone can be increased when combined with Rifampicin.Approved
EthanolThe metabolism of Ethanol can be increased when combined with Rifampicin.Approved
Ethinyl EstradiolThe metabolism of Ethinyl Estradiol can be increased when combined with Rifampicin.Approved
EthosuximideThe metabolism of Ethosuximide can be increased when combined with Rifampicin.Approved
Ethyl biscoumacetateThe metabolism of Ethyl biscoumacetate can be increased when combined with Rifampicin.Withdrawn
EthylmorphineThe metabolism of Ethylmorphine can be increased when combined with Rifampicin.Approved, Illicit
Ethynodiol diacetateThe serum concentration of Ethynodiol diacetate can be decreased when it is combined with Rifampicin.Approved
EtodolacThe metabolism of Etodolac can be increased when combined with Rifampicin.Approved, Investigational, Vet Approved
EtonogestrelThe metabolism of Etonogestrel can be increased when combined with Rifampicin.Approved, Investigational
EtoposideThe serum concentration of Etoposide can be decreased when it is combined with Rifampicin.Approved
EtoricoxibThe metabolism of Etoricoxib can be increased when combined with Rifampicin.Approved, Investigational
EtravirineThe serum concentration of Etravirine can be decreased when it is combined with Rifampicin.Approved
EverolimusThe serum concentration of Everolimus can be decreased when it is combined with Rifampicin.Approved
ExemestaneThe serum concentration of Exemestane can be decreased when it is combined with Rifampicin.Approved, Investigational
EzetimibeThe serum concentration of Ezetimibe can be decreased when it is combined with Rifampicin.Approved
FamciclovirThe metabolism of Famciclovir can be increased when combined with Rifampicin.Approved
FamotidineThe metabolism of Famotidine can be increased when combined with Rifampicin.Approved
FelbamateThe metabolism of Felbamate can be increased when combined with Rifampicin.Approved
FelodipineThe metabolism of Felodipine can be increased when combined with Rifampicin.Approved, Investigational
FendilineThe serum concentration of Fendiline can be decreased when it is combined with Rifampicin.Withdrawn
FenofibrateThe metabolism of Fenofibrate can be increased when combined with Rifampicin.Approved
FentanylThe serum concentration of Fentanyl can be decreased when it is combined with Rifampicin.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe metabolism of Fesoterodine can be increased when combined with Rifampicin.Approved
FexofenadineThe serum concentration of Fexofenadine can be decreased when it is combined with Rifampicin.Approved
FidaxomicinThe serum concentration of Fidaxomicin can be decreased when it is combined with Rifampicin.Approved
FimasartanThe serum concentration of Fimasartan can be increased when it is combined with Rifampicin.Approved
FinasterideThe metabolism of Finasteride can be increased when combined with Rifampicin.Approved
FingolimodThe metabolism of Fingolimod can be increased when combined with Rifampicin.Approved, Investigational
FlibanserinThe serum concentration of Flibanserin can be decreased when it is combined with Rifampicin.Approved
FloxuridineThe metabolism of Rifampicin can be decreased when combined with Floxuridine.Approved
fluasteroneThe serum concentration of fluasterone can be decreased when it is combined with Rifampicin.Investigational
FluconazoleThe metabolism of Rifampicin can be decreased when combined with Fluconazole.Approved
FlucytosineThe serum concentration of Rifampicin can be increased when it is combined with Flucytosine.Approved
FludrocortisoneThe serum concentration of Fludrocortisone can be decreased when it is combined with Rifampicin.Approved
FluindioneThe metabolism of Fluindione can be increased when combined with Rifampicin.Investigational
FlumethasoneThe serum concentration of Flumethasone can be decreased when it is combined with Rifampicin.Approved, Vet Approved
FlunarizineThe metabolism of Flunarizine can be increased when combined with Rifampicin.Approved
FlunisolideThe metabolism of Flunisolide can be increased when combined with Rifampicin.Approved, Investigational
FlunitrazepamThe metabolism of Flunitrazepam can be increased when combined with Rifampicin.Approved, Illicit
Fluocinolone AcetonideThe serum concentration of Fluocinolone Acetonide can be decreased when it is combined with Rifampicin.Approved, Investigational, Vet Approved
FluocinonideThe serum concentration of Fluocinonide can be decreased when it is combined with Rifampicin.Approved, Investigational
FluocortoloneThe serum concentration of Fluocortolone can be decreased when it is combined with Rifampicin.Approved, Withdrawn
FluorometholoneThe metabolism of Fluorometholone can be increased when combined with Rifampicin.Approved
FluorouracilThe metabolism of Fluorouracil can be increased when combined with Rifampicin.Approved
FluoxetineThe metabolism of Fluoxetine can be increased when combined with Rifampicin.Approved, Vet Approved
FlupentixolThe serum concentration of Rifampicin can be increased when it is combined with Flupentixol.Approved, Withdrawn
FluphenazineThe serum concentration of Rifampicin can be increased when it is combined with Fluphenazine.Approved
FluprednideneThe serum concentration of Fluprednidene can be decreased when it is combined with Rifampicin.Approved, Withdrawn
FluprednisoloneThe serum concentration of Fluprednisolone can be decreased when it is combined with Rifampicin.Approved
FlurandrenolideThe serum concentration of Flurandrenolide can be decreased when it is combined with Rifampicin.Approved
FlurazepamThe metabolism of Flurazepam can be increased when combined with Rifampicin.Approved, Illicit
FlurbiprofenThe metabolism of Flurbiprofen can be increased when combined with Rifampicin.Approved, Investigational
FlutamideThe metabolism of Flutamide can be increased when combined with Rifampicin.Approved
Fluticasone furoateThe metabolism of Fluticasone furoate can be increased when combined with Rifampicin.Approved
Fluticasone PropionateThe metabolism of Fluticasone Propionate can be increased when combined with Rifampicin.Approved
FluvastatinThe metabolism of Fluvastatin can be increased when combined with Rifampicin.Approved
FluvoxamineThe metabolism of Fluvoxamine can be increased when combined with Rifampicin.Approved, Investigational
FormestaneThe serum concentration of Formestane can be decreased when it is combined with Rifampicin.Approved, Investigational, Withdrawn
FormoterolThe metabolism of Formoterol can be increased when combined with Rifampicin.Approved, Investigational
FosamprenavirThe serum concentration of Fosamprenavir can be decreased when it is combined with Rifampicin.Approved
FosaprepitantThe serum concentration of Fosaprepitant can be decreased when it is combined with Rifampicin.Approved
FosphenytoinThe serum concentration of Fosphenytoin can be decreased when it is combined with Rifampicin.Approved
FrovatriptanThe metabolism of Frovatriptan can be increased when combined with Rifampicin.Approved, Investigational
FulvestrantThe metabolism of Fulvestrant can be increased when combined with Rifampicin.Approved, Investigational
Fusidic AcidThe serum concentration of Rifampicin can be increased when it is combined with Fusidic Acid.Approved
GabapentinThe serum concentration of Gabapentin can be decreased when it is combined with Rifampicin.Approved, Investigational
GalantamineThe metabolism of Galantamine can be increased when combined with Rifampicin.Approved
GallopamilThe serum concentration of Gallopamil can be decreased when it is combined with Rifampicin.Investigational
GavestinelThe metabolism of Gavestinel can be increased when combined with Rifampicin.Investigational
GefitinibThe serum concentration of Gefitinib can be decreased when it is combined with Rifampicin.Approved, Investigational
GemcitabineThe serum concentration of Gemcitabine can be decreased when it is combined with Rifampicin.Approved
GemfibrozilThe metabolism of Gemfibrozil can be increased when combined with Rifampicin.Approved
GenisteinThe metabolism of Genistein can be increased when combined with Rifampicin.Investigational
GestodeneThe serum concentration of Gestodene can be decreased when it is combined with Rifampicin.Approved
GlibornurideThe serum concentration of Glibornuride can be decreased when it is combined with Rifampicin.Withdrawn
GliclazideThe serum concentration of Gliclazide can be decreased when it is combined with Rifampicin.Approved
GlimepirideThe serum concentration of Glimepiride can be decreased when it is combined with Rifampicin.Approved
GlipizideThe serum concentration of Glipizide can be decreased when it is combined with Rifampicin.Approved
GliquidoneThe serum concentration of Gliquidone can be decreased when it is combined with Rifampicin.Approved
GlisoxepideThe serum concentration of Glisoxepide can be decreased when it is combined with Rifampicin.Approved
GlucosamineThe metabolism of Glucosamine can be increased when combined with Rifampicin.Approved
GlyburideThe serum concentration of Glyburide can be decreased when it is combined with Rifampicin.Approved
GlycerolThe serum concentration of Rifampicin can be increased when it is combined with Glycerol.Experimental
GlyphosateThe serum concentration of Rifampicin can be increased when it is combined with Glyphosate.Experimental
Gramicidin DThe serum concentration of Rifampicin can be increased when it is combined with Gramicidin D.Approved
GranisetronThe metabolism of Granisetron can be increased when combined with Rifampicin.Approved, Investigational
GrazoprevirThe serum concentration of Grazoprevir can be decreased when it is combined with Rifampicin.Approved
GrepafloxacinThe metabolism of Grepafloxacin can be increased when combined with Rifampicin.Withdrawn
GriseofulvinThe serum concentration of Rifampicin can be increased when it is combined with Griseofulvin.Approved, Vet Approved
GuanabenzThe metabolism of Guanabenz can be increased when combined with Rifampicin.Approved
GuanfacineThe serum concentration of Guanfacine can be decreased when it is combined with Rifampicin.Approved, Investigational
HalofantrineThe metabolism of Halofantrine can be increased when combined with Rifampicin.Approved
HaloperidolThe metabolism of Haloperidol can be increased when combined with Rifampicin.Approved
HaloproginThe serum concentration of Rifampicin can be increased when it is combined with Haloprogin.Approved, Withdrawn
HalothaneThe metabolism of Halothane can be increased when combined with Rifampicin.Approved, Vet Approved
HE3286The serum concentration of HE3286 can be decreased when it is combined with Rifampicin.Investigational
HesperetinThe metabolism of Hesperetin can be increased when combined with Rifampicin.Approved
HexestrolThe serum concentration of Hexestrol can be decreased when it is combined with Rifampicin.Withdrawn
HexetidineThe serum concentration of Rifampicin can be increased when it is combined with Hexetidine.Approved
HexobarbitalThe metabolism of Hexobarbital can be increased when combined with Rifampicin.Approved
Histamine PhosphateThe metabolism of Histamine Phosphate can be increased when combined with Rifampicin.Approved
HydrocodoneThe serum concentration of Hydrocodone can be decreased when it is combined with Rifampicin.Approved, Illicit
HydrocortisoneThe metabolism of Hydrocortisone can be increased when combined with Rifampicin.Approved, Vet Approved
HydrocortisoneThe serum concentration of Hydrocortisone can be decreased when it is combined with Rifampicin.Approved, Vet Approved
HydromorphoneThe metabolism of Hydromorphone can be increased when combined with Rifampicin.Approved, Illicit
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be increased when combined with Rifampicin.Approved
IbrutinibThe serum concentration of Ibrutinib can be decreased when it is combined with Rifampicin.Approved
IbuprofenThe metabolism of Ibuprofen can be increased when combined with Rifampicin.Approved
IdarubicinThe metabolism of Idarubicin can be increased when combined with Rifampicin.Approved
IdelalisibThe serum concentration of Rifampicin can be increased when it is combined with Idelalisib.Approved
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be increased when Ifosfamide is used in combination with Rifampicin.Approved
IloperidoneThe metabolism of Iloperidone can be increased when combined with Rifampicin.Approved
ImatinibThe serum concentration of Imatinib can be decreased when it is combined with Rifampicin.Approved
ImipramineThe metabolism of Imipramine can be increased when combined with Rifampicin.Approved
ImiquimodThe metabolism of Imiquimod can be increased when combined with Rifampicin.Approved, Investigational
IndacaterolThe metabolism of Indacaterol can be increased when combined with Rifampicin.Approved
IndapamideThe metabolism of Indapamide can be increased when combined with Rifampicin.Approved
IndenololThe serum concentration of Indenolol can be decreased when it is combined with Rifampicin.Withdrawn
IndinavirThe serum concentration of Indinavir can be decreased when it is combined with Rifampicin.Approved
indisulamThe metabolism of indisulam can be increased when combined with Rifampicin.Investigational
IndomethacinThe metabolism of Indomethacin can be increased when combined with Rifampicin.Approved, Investigational
Ipratropium bromideThe metabolism of Ipratropium bromide can be increased when combined with Rifampicin.Approved
IrbesartanThe metabolism of Irbesartan can be increased when combined with Rifampicin.Approved, Investigational
IrinotecanThe serum concentration of the active metabolites of Irinotecan can be reduced when Irinotecan is used in combination with Rifampicin resulting in a loss in efficacy.Approved, Investigational
IsavuconazoniumThe serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Rifampicin resulting in a loss in efficacy.Approved, Investigational
IsoconazoleThe serum concentration of Rifampicin can be increased when it is combined with Isoconazole.Approved
IsofluraneThe metabolism of Isoflurane can be increased when combined with Rifampicin.Approved, Vet Approved
IsoniazidRifampicin may increase the hepatotoxic activities of Isoniazid.Approved
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be increased when combined with Rifampicin.Approved
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be increased when combined with Rifampicin.Approved
IsradipineThe metabolism of Isradipine can be increased when combined with Rifampicin.Approved
IstaroximeThe serum concentration of Istaroxime can be decreased when it is combined with Rifampicin.Investigational
ItraconazoleThe serum concentration of Itraconazole can be decreased when it is combined with Rifampicin.Approved, Investigational
IvabradineThe serum concentration of Ivabradine can be decreased when it is combined with Rifampicin.Approved
IvacaftorThe serum concentration of Ivacaftor can be decreased when it is combined with Rifampicin.Approved
IvermectinThe metabolism of Ivermectin can be increased when combined with Rifampicin.Approved, Vet Approved
IxabepiloneThe serum concentration of Ixabepilone can be decreased when it is combined with Rifampicin.Approved, Investigational
IxazomibThe serum concentration of Ixazomib can be decreased when it is combined with Rifampicin.Approved
JosamycinThe metabolism of Rifampicin can be decreased when combined with Josamycin.Approved
KetamineThe metabolism of Ketamine can be increased when combined with Rifampicin.Approved, Vet Approved
KetazolamThe metabolism of Ketazolam can be increased when combined with Rifampicin.Approved
KetobemidoneThe metabolism of Ketobemidone can be increased when combined with Rifampicin.Approved
KetoconazoleThe metabolism of Ketoconazole can be increased when combined with Rifampicin.Approved, Investigational
KetoprofenThe metabolism of Ketoprofen can be increased when combined with Rifampicin.Approved, Vet Approved
KitasamycinThe metabolism of Rifampicin can be decreased when combined with Kitasamycin.Experimental
LabetalolThe serum concentration of Labetalol can be decreased when it is combined with Rifampicin.Approved
LacidipineThe serum concentration of Lacidipine can be decreased when it is combined with Rifampicin.Approved
LamivudineThe serum concentration of Lamivudine can be decreased when it is combined with Rifampicin.Approved, Investigational
LamotrigineThe metabolism of Lamotrigine can be increased when combined with Rifampicin.Approved, Investigational
LansoprazoleThe metabolism of Lansoprazole can be increased when combined with Rifampicin.Approved, Investigational
LapatinibThe serum concentration of Lapatinib can be decreased when it is combined with Rifampicin.Approved, Investigational
LaquinimodThe metabolism of Laquinimod can be increased when combined with Rifampicin.Investigational
LedipasvirThe serum concentration of Ledipasvir can be decreased when it is combined with Rifampicin.Approved
LeflunomideThe serum concentration of the active metabolites of Leflunomide can be increased when Leflunomide is used in combination with Rifampicin.Approved, Investigational
LenalidomideThe serum concentration of Lenalidomide can be decreased when it is combined with Rifampicin.Approved
LenvatinibThe metabolism of Lenvatinib can be increased when combined with Rifampicin.Approved
LercanidipineThe metabolism of Lercanidipine can be increased when combined with Rifampicin.Approved, Investigational
LesinuradThe metabolism of Lesinurad can be increased when combined with Rifampicin.Approved
LetrozoleThe metabolism of Letrozole can be increased when combined with Rifampicin.Approved, Investigational
LevetiracetamThe serum concentration of Levetiracetam can be decreased when it is combined with Rifampicin.Approved, Investigational
LevobunololThe serum concentration of Levobunolol can be decreased when it is combined with Rifampicin.Approved
LevobupivacaineThe metabolism of Levobupivacaine can be increased when combined with Rifampicin.Approved
LevocetirizineThe metabolism of Levocetirizine can be increased when combined with Rifampicin.Approved
LevofloxacinThe serum concentration of Levofloxacin can be decreased when it is combined with Rifampicin.Approved, Investigational
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be increased when combined with Rifampicin.Approved
LevomilnacipranThe metabolism of Levomilnacipran can be increased when combined with Rifampicin.Approved
LevonorgestrelThe metabolism of Levonorgestrel can be increased when combined with Rifampicin.Approved, Investigational
LevothyroxineThe serum concentration of Levothyroxine can be decreased when it is combined with Rifampicin.Approved
LicofeloneThe metabolism of Licofelone can be increased when combined with Rifampicin.Investigational
LidocaineThe metabolism of Lidocaine can be increased when combined with Rifampicin.Approved, Vet Approved
LinagliptinThe serum concentration of Linagliptin can be decreased when it is combined with Rifampicin.Approved
LiothyronineThe serum concentration of Liothyronine can be decreased when it is combined with Rifampicin.Approved, Vet Approved
LiotrixThe serum concentration of Liotrix can be decreased when it is combined with Rifampicin.Approved
LisinoprilThe serum concentration of Rifampicin can be increased when it is combined with Lisinopril.Approved, Investigational
LisurideThe metabolism of Lisuride can be increased when combined with Rifampicin.Approved
LomefloxacinThe metabolism of Lomefloxacin can be increased when combined with Rifampicin.Approved
LomitapideThe metabolism of Lomitapide can be increased when combined with Rifampicin.Approved
LoperamideThe metabolism of Loperamide can be increased when combined with Rifampicin.Approved
LopinavirThe risk or severity of adverse effects can be increased when Rifampicin is combined with Lopinavir.Approved
LoratadineThe metabolism of Loratadine can be increased when combined with Rifampicin.Approved
LorcaserinThe metabolism of Lorcaserin can be increased when combined with Rifampicin.Approved
LornoxicamThe metabolism of Lornoxicam can be increased when combined with Rifampicin.Approved
LosartanThe serum concentration of Losartan can be decreased when it is combined with Rifampicin.Approved
LovastatinThe metabolism of Lovastatin can be increased when combined with Rifampicin.Approved, Investigational
LuliconazoleThe serum concentration of Rifampicin can be increased when it is combined with Luliconazole.Approved
LumacaftorThe serum concentration of Rifampicin can be increased when it is combined with Lumacaftor.Approved
LumefantrineThe serum concentration of Lumefantrine can be decreased when it is combined with Rifampicin.Approved
LumiracoxibThe metabolism of Lumiracoxib can be increased when combined with Rifampicin.Approved, Investigational
LurasidoneThe serum concentration of Lurasidone can be decreased when it is combined with Rifampicin.Approved
LynestrenolThe serum concentration of Lynestrenol can be decreased when it is combined with Rifampicin.Investigational
MacitentanThe serum concentration of Macitentan can be decreased when it is combined with Rifampicin.Approved
Magnesium SulfateThe serum concentration of Magnesium Sulfate can be decreased when it is combined with Rifampicin.Approved, Vet Approved
MalathionThe metabolism of Malathion can be increased when combined with Rifampicin.Approved, Investigational
ManidipineThe serum concentration of Manidipine can be decreased when it is combined with Rifampicin.Approved
MannitolThe serum concentration of Mannitol can be decreased when it is combined with Rifampicin.Approved, Investigational
MaprotilineThe metabolism of Maprotiline can be increased when combined with Rifampicin.Approved
MaravirocThe serum concentration of Maraviroc can be decreased when it is combined with Rifampicin.Approved, Investigational
ME-609The serum concentration of ME-609 can be decreased when it is combined with Rifampicin.Investigational
MebendazoleThe metabolism of Mebendazole can be increased when combined with Rifampicin.Approved, Vet Approved
Medroxyprogesterone acetateThe metabolism of Medroxyprogesterone acetate can be increased when combined with Rifampicin.Approved, Investigational
MedrysoneThe serum concentration of Medrysone can be decreased when it is combined with Rifampicin.Approved
Mefenamic acidThe metabolism of Mefenamic acid can be increased when combined with Rifampicin.Approved
MefloquineThe metabolism of Mefloquine can be increased when combined with Rifampicin.Approved
Megestrol acetateThe serum concentration of Rifampicin can be increased when it is combined with Megestrol acetate.Approved, Vet Approved
MelatoninThe metabolism of Melatonin can be increased when combined with Rifampicin.Approved, Nutraceutical, Vet Approved
MelengestrolThe serum concentration of Melengestrol can be decreased when it is combined with Rifampicin.Vet Approved
MeloxicamThe metabolism of Meloxicam can be increased when combined with Rifampicin.Approved, Vet Approved
MenadioneThe metabolism of Menadione can be increased when combined with Rifampicin.Approved, Nutraceutical
MephenytoinThe metabolism of Mephenytoin can be increased when combined with Rifampicin.Investigational, Withdrawn
MeprobamateThe metabolism of Meprobamate can be increased when combined with Rifampicin.Approved, Illicit
MestranolThe metabolism of Mestranol can be increased when combined with Rifampicin.Approved
MethadoneThe serum concentration of Methadone can be decreased when it is combined with Rifampicin.Approved
MethallenestrilThe serum concentration of Methallenestril can be decreased when it is combined with Rifampicin.Experimental
MethaqualoneThe metabolism of Methaqualone can be increased when combined with Rifampicin.Illicit, Withdrawn
MethohexitalThe metabolism of Methohexital can be increased when combined with Rifampicin.Approved
MethotrexateThe serum concentration of Methotrexate can be decreased when it is combined with Rifampicin.Approved
MethoxsalenThe metabolism of Methoxsalen can be increased when combined with Rifampicin.Approved
MethoxyfluraneThe metabolism of Methoxyflurane can be increased when combined with Rifampicin.Approved, Vet Approved
MethsuximideThe metabolism of Methsuximide can be increased when combined with Rifampicin.Approved
MethylphenobarbitalThe metabolism of Methylphenobarbital can be increased when combined with Rifampicin.Approved
MethylprednisoloneThe serum concentration of Methylprednisolone can be decreased when it is combined with Rifampicin.Approved, Vet Approved
MethyltestosteroneThe metabolism of Methyltestosterone can be increased when combined with Rifampicin.Approved
MetipranololThe serum concentration of Metipranolol can be decreased when it is combined with Rifampicin.Approved
MetoprololThe metabolism of Metoprolol can be increased when combined with Rifampicin.Approved, Investigational
MetronidazoleThe metabolism of Metronidazole can be increased when combined with Rifampicin.Approved
MevastatinThe serum concentration of Mevastatin can be decreased when it is combined with Rifampicin.Experimental
MexiletineThe metabolism of Mexiletine can be increased when combined with Rifampicin.Approved
MianserinThe metabolism of Mianserin can be increased when combined with Rifampicin.Approved
MibefradilThe metabolism of Mibefradil can be increased when combined with Rifampicin.Withdrawn
MicafunginThe serum concentration of Rifampicin can be increased when it is combined with Micafungin.Approved, Investigational
MiconazoleThe metabolism of Miconazole can be increased when combined with Rifampicin.Approved, Investigational, Vet Approved
MidazolamThe metabolism of Midazolam can be increased when combined with Rifampicin.Approved, Illicit
MifepristoneThe serum concentration of Mifepristone can be decreased when it is combined with Rifampicin.Approved, Investigational
MiltefosineThe serum concentration of Rifampicin can be increased when it is combined with Miltefosine.Approved
MirabegronThe serum concentration of Mirabegron can be decreased when it is combined with Rifampicin.Approved
MirtazapineThe metabolism of Mirtazapine can be increased when combined with Rifampicin.Approved
MitomycinThe serum concentration of Rifampicin can be increased when it is combined with Mitomycin.Approved
MitotaneThe serum concentration of Rifampicin can be decreased when it is combined with Mitotane.Approved
MitoxantroneThe serum concentration of Mitoxantrone can be decreased when it is combined with Rifampicin.Approved, Investigational
MoclobemideThe metabolism of Moclobemide can be increased when combined with Rifampicin.Approved
ModafinilThe metabolism of Modafinil can be increased when combined with Rifampicin.Approved, Investigational
MometasoneThe serum concentration of Mometasone can be decreased when it is combined with Rifampicin.Approved, Vet Approved
MonensinThe serum concentration of Rifampicin can be increased when it is combined with Monensin.Vet Approved
MontelukastThe metabolism of Montelukast can be increased when combined with Rifampicin.Approved
MorphineThe metabolism of Morphine can be increased when combined with Rifampicin.Approved, Investigational
MorphineThe serum concentration of Morphine can be decreased when it is combined with Rifampicin.Approved, Investigational
muraglitazarThe metabolism of muraglitazar can be increased when combined with Rifampicin.Investigational
Mycophenolate mofetilThe metabolism of Mycophenolate mofetil can be increased when combined with Rifampicin.Approved, Investigational
Mycophenolic acidThe serum concentration of Mycophenolic acid can be decreased when it is combined with Rifampicin.Approved
MyxothiazolThe serum concentration of Rifampicin can be increased when it is combined with Myxothiazol.Experimental
NabumetoneThe metabolism of Nabumetone can be increased when combined with Rifampicin.Approved
NadololThe serum concentration of Nadolol can be decreased when it is combined with Rifampicin.Approved
NafcillinThe serum concentration of Rifampicin can be decreased when it is combined with Nafcillin.Approved
NaftifineThe serum concentration of Rifampicin can be increased when it is combined with Naftifine.Approved
NaftopidilThe serum concentration of Naftopidil can be decreased when it is combined with Rifampicin.Investigational
NaloxegolThe serum concentration of Naloxegol can be decreased when it is combined with Rifampicin.Approved
NaloxoneThe metabolism of Naloxone can be increased when combined with Rifampicin.Approved, Vet Approved
NaltrexoneThe serum concentration of Rifampicin can be increased when it is combined with Naltrexone.Approved, Investigational, Vet Approved
NaproxenThe metabolism of Naproxen can be increased when combined with Rifampicin.Approved, Vet Approved
NaringeninThe serum concentration of Rifampicin can be increased when it is combined with Naringenin.Experimental
NatamycinThe serum concentration of Rifampicin can be increased when it is combined with Natamycin.Approved
NateglinideThe metabolism of Nateglinide can be increased when combined with Rifampicin.Approved, Investigational
NCX 1022The serum concentration of NCX 1022 can be decreased when it is combined with Rifampicin.Investigational
NefazodoneThe metabolism of Nefazodone can be increased when combined with Rifampicin.Approved, Withdrawn
NelfinavirThe serum concentration of Nelfinavir can be decreased when it is combined with Rifampicin.Approved
NeostigmineThe serum concentration of Rifampicin can be increased when it is combined with Neostigmine.Approved, Vet Approved
NetupitantThe serum concentration of Netupitant can be decreased when it is combined with Rifampicin.Approved
NevirapineThe serum concentration of Nevirapine can be decreased when it is combined with Rifampicin.Approved
NicardipineThe metabolism of Nicardipine can be increased when combined with Rifampicin.Approved
NiclosamideThe metabolism of Niclosamide can be increased when combined with Rifampicin.Approved, Vet Approved
NicotineThe metabolism of Nicotine can be increased when combined with Rifampicin.Approved
NifedipineThe serum concentration of Nifedipine can be decreased when it is combined with Rifampicin.Approved
NiguldipineThe serum concentration of Niguldipine can be decreased when it is combined with Rifampicin.Experimental
NilotinibThe serum concentration of Nilotinib can be decreased when it is combined with Rifampicin.Approved, Investigational
NiludipineThe serum concentration of Niludipine can be decreased when it is combined with Rifampicin.Experimental
NilutamideThe metabolism of Nilutamide can be increased when combined with Rifampicin.Approved
NilvadipineThe metabolism of Nilvadipine can be increased when combined with Rifampicin.Approved
NimesulideThe serum concentration of Nimesulide can be decreased when it is combined with Rifampicin.Approved, Withdrawn
NimodipineThe serum concentration of Nimodipine can be decreased when it is combined with Rifampicin.Approved
NintedanibThe serum concentration of Nintedanib can be decreased when it is combined with Rifampicin.Approved
NisoldipineThe serum concentration of Nisoldipine can be decreased when it is combined with Rifampicin.Approved
NitrazepamThe serum concentration of Nitrazepam can be decreased when it is combined with Rifampicin.Approved
NitrendipineThe metabolism of Nitrendipine can be increased when combined with Rifampicin.Approved
Nitric OxideThe metabolism of Nitric Oxide can be increased when combined with Rifampicin.Approved
NitroxolineThe serum concentration of Rifampicin can be increased when it is combined with Nitroxoline.Approved
NizatidineThe serum concentration of Nizatidine can be decreased when it is combined with Rifampicin.Approved
NorelgestrominThe serum concentration of Norelgestromin can be decreased when it is combined with Rifampicin.Approved
NorethisteroneThe metabolism of Norethisterone can be increased when combined with Rifampicin.Approved
NorgestimateThe serum concentration of Norgestimate can be decreased when it is combined with Rifampicin.Approved
NorgestrelThe metabolism of Norgestrel can be increased when combined with Rifampicin.Approved
NortriptylineThe metabolism of Nortriptyline can be increased when combined with Rifampicin.Approved
NystatinThe serum concentration of Rifampicin can be increased when it is combined with Nystatin.Approved, Vet Approved
OlanzapineThe metabolism of Olanzapine can be increased when combined with Rifampicin.Approved, Investigational
OlaparibThe serum concentration of Olaparib can be decreased when it is combined with Rifampicin.Approved
OleandomycinThe metabolism of Rifampicin can be decreased when combined with Oleandomycin.Vet Approved
Oleoyl estroneThe serum concentration of Oleoyl estrone can be decreased when it is combined with Rifampicin.Investigational
OlodaterolThe metabolism of Olodaterol can be increased when combined with Rifampicin.Approved
OlopatadineThe metabolism of Olopatadine can be increased when combined with Rifampicin.Approved
OmbitasvirThe serum concentration of Ombitasvir can be decreased when it is combined with Rifampicin.Approved
OmeprazoleThe serum concentration of Omeprazole can be decreased when it is combined with Rifampicin.Approved, Investigational, Vet Approved
OndansetronThe metabolism of Ondansetron can be increased when combined with Rifampicin.Approved
OrphenadrineThe metabolism of Orphenadrine can be increased when combined with Rifampicin.Approved
OsimertinibThe serum concentration of Osimertinib can be decreased when it is combined with Rifampicin.Approved
OspemifeneThe metabolism of Ospemifene can be increased when combined with Rifampicin.Approved
OxaliplatinThe metabolism of Oxaliplatin can be increased when combined with Rifampicin.Approved, Investigational
OxaprozinThe metabolism of Oxaprozin can be increased when combined with Rifampicin.Approved
OxazepamThe metabolism of Oxazepam can be increased when combined with Rifampicin.Approved
OxiconazoleThe metabolism of Oxiconazole can be increased when combined with Rifampicin.Approved
OxprenololThe serum concentration of Oxprenolol can be decreased when it is combined with Rifampicin.Approved
OxtriphyllineThe metabolism of Oxtriphylline can be increased when combined with Rifampicin.Approved
OxybutyninThe metabolism of Oxybutynin can be increased when combined with Rifampicin.Approved, Investigational
OxycodoneThe serum concentration of Oxycodone can be decreased when it is combined with Rifampicin.Approved, Illicit, Investigational
OxymorphoneThe metabolism of Oxymorphone can be increased when combined with Rifampicin.Approved, Investigational, Vet Approved
P-NitrophenolThe serum concentration of Rifampicin can be increased when it is combined with P-Nitrophenol.Experimental
PaclitaxelThe metabolism of Paclitaxel can be increased when combined with Rifampicin.Approved, Vet Approved
pafuramidineThe serum concentration of Rifampicin can be increased when it is combined with pafuramidine.Investigational
PalbociclibThe serum concentration of Palbociclib can be decreased when it is combined with Rifampicin.Approved
Palmitic AcidThe serum concentration of Rifampicin can be increased when it is combined with Palmitic Acid.Experimental
PalonosetronThe metabolism of Palonosetron can be increased when combined with Rifampicin.Approved, Investigational
PanobinostatThe serum concentration of Panobinostat can be decreased when it is combined with Rifampicin.Approved, Investigational
PantoprazoleThe metabolism of Pantoprazole can be increased when combined with Rifampicin.Approved
ParamethadioneThe metabolism of Paramethadione can be increased when combined with Rifampicin.Approved
ParamethasoneThe metabolism of Paramethasone can be increased when combined with Rifampicin.Approved
ParecoxibThe metabolism of Parecoxib can be increased when combined with Rifampicin.Approved
ParicalcitolThe metabolism of Paricalcitol can be increased when combined with Rifampicin.Approved, Investigational
ParitaprevirThe serum concentration of Paritaprevir can be decreased when it is combined with Rifampicin.Approved
ParoxetineThe serum concentration of Rifampicin can be increased when it is combined with Paroxetine.Approved, Investigational
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Rifampicin.Approved
PenbutololThe serum concentration of Penbutolol can be decreased when it is combined with Rifampicin.Approved, Investigational
PentamidineThe metabolism of Pentamidine can be increased when combined with Rifampicin.Approved
PentobarbitalThe metabolism of Rifampicin can be increased when combined with Pentobarbital.Approved, Vet Approved
PentoxifyllineThe metabolism of Pentoxifylline can be increased when combined with Rifampicin.Approved, Investigational
PerampanelThe serum concentration of Perampanel can be decreased when it is combined with Rifampicin.Approved
PergolideThe metabolism of Pergolide can be increased when combined with Rifampicin.Approved, Vet Approved, Withdrawn
PerhexilineThe metabolism of Perhexiline can be increased when combined with Rifampicin.Approved
PerindoprilThe serum concentration of Rifampicin can be increased when it is combined with Perindopril.Approved
PermethrinThe metabolism of Permethrin can be increased when combined with Rifampicin.Approved, Investigational
PerphenazineThe metabolism of Perphenazine can be increased when combined with Rifampicin.Approved
PethidineThe metabolism of Pethidine can be increased when combined with Rifampicin.Approved
PhenacetinThe metabolism of Phenacetin can be increased when combined with Rifampicin.Withdrawn
PhenindioneThe metabolism of Phenindione can be increased when combined with Rifampicin.Approved
PhenobarbitalThe metabolism of Rifampicin can be increased when combined with Phenobarbital.Approved
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be increased when combined with Rifampicin.Approved
PhenprocoumonThe metabolism of Phenprocoumon can be increased when combined with Rifampicin.Approved
PhenylbutazoneThe metabolism of Phenylbutazone can be increased when combined with Rifampicin.Approved, Vet Approved
PhenytoinThe serum concentration of Phenytoin can be decreased when it is combined with Rifampicin.Approved, Vet Approved
Picosulfuric acidThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Rifampicin.Approved
PilocarpineThe metabolism of Pilocarpine can be increased when combined with Rifampicin.Approved
PimecrolimusThe metabolism of Pimecrolimus can be increased when combined with Rifampicin.Approved, Investigational
PimozideThe metabolism of Pimozide can be increased when combined with Rifampicin.Approved
PinacidilThe metabolism of Pinacidil can be increased when combined with Rifampicin.Withdrawn
PinaveriumThe serum concentration of Pinaverium can be decreased when it is combined with Rifampicin.Approved
PindololThe serum concentration of Pindolol can be decreased when it is combined with Rifampicin.Approved
PioglitazoneThe metabolism of Pioglitazone can be increased when combined with Rifampicin.Approved, Investigational
PipotiazineThe metabolism of Pipotiazine can be increased when combined with Rifampicin.Approved
PirfenidoneThe serum concentration of Pirfenidone can be decreased when it is combined with Rifampicin.Investigational
PiroxicamThe metabolism of Piroxicam can be increased when combined with Rifampicin.Approved, Investigational
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Rifampicin.Approved
Platelet Activating FactorThe serum concentration of Rifampicin can be decreased when it is combined with Platelet Activating Factor.Experimental
PodofiloxThe metabolism of Podofilox can be increased when combined with Rifampicin.Approved
PomalidomideThe metabolism of Pomalidomide can be increased when combined with Rifampicin.Approved
PonatinibThe serum concentration of Ponatinib can be decreased when it is combined with Rifampicin.Approved
PosaconazoleThe metabolism of Posaconazole can be increased when combined with Rifampicin.Approved, Investigational, Vet Approved
PractololThe serum concentration of Practolol can be decreased when it is combined with Rifampicin.Approved
PrasteroneThe metabolism of Prasterone can be increased when combined with Rifampicin.Approved, Nutraceutical
PrasugrelRifampicin may decrease the antiplatelet activities of Prasugrel.Approved
PravastatinThe metabolism of Pravastatin can be increased when combined with Rifampicin.Approved
PrazepamThe metabolism of Prazepam can be increased when combined with Rifampicin.Approved, Illicit
PraziquantelThe serum concentration of Praziquantel can be decreased when it is combined with Rifampicin.Approved, Vet Approved
PrazosinThe serum concentration of Prazosin can be decreased when it is combined with Rifampicin.Approved
PrednicarbateThe serum concentration of Prednicarbate can be decreased when it is combined with Rifampicin.Approved
PrednisoloneThe metabolism of Prednisolone can be increased when combined with Rifampicin.Approved, Vet Approved
PrednisoloneThe serum concentration of Prednisolone can be decreased when it is combined with Rifampicin.Approved, Vet Approved
PrednisoneThe serum concentration of Prednisone can be decreased when it is combined with Rifampicin.Approved, Vet Approved
PregabalinThe serum concentration of Pregabalin can be decreased when it is combined with Rifampicin.Approved, Illicit, Investigational
PregnenoloneThe serum concentration of Pregnenolone can be decreased when it is combined with Rifampicin.Experimental
PrenylamineThe serum concentration of Prenylamine can be decreased when it is combined with Rifampicin.Withdrawn
PrimaquineThe metabolism of Primaquine can be increased when combined with Rifampicin.Approved
PrimidoneThe metabolism of Rifampicin can be increased when combined with Primidone.Approved, Vet Approved
ProbenecidThe serum concentration of Rifampicin can be increased when it is combined with Probenecid.Approved
ProchlorperazineThe metabolism of Prochlorperazine can be increased when combined with Rifampicin.Approved, Vet Approved
ProgesteroneThe metabolism of Progesterone can be increased when combined with Rifampicin.Approved, Vet Approved
ProguanilThe metabolism of Proguanil can be increased when combined with Rifampicin.Approved
PromazineThe metabolism of Promazine can be increased when combined with Rifampicin.Approved, Vet Approved
PromethazineThe metabolism of Promethazine can be increased when combined with Rifampicin.Approved
PropafenoneThe serum concentration of Propafenone can be decreased when it is combined with Rifampicin.Approved
PropofolRifampicin may increase the hypotensive activities of Propofol.Approved, Investigational, Vet Approved
PropranololThe metabolism of Propranolol can be increased when combined with Rifampicin.Approved, Investigational
ProtriptylineThe serum concentration of Rifampicin can be increased when it is combined with Protriptyline.Approved
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Rifampicin.Approved
PyrazinamidePyrazinamide may increase the hepatotoxic activities of Rifampicin.Approved
PyrimethamineThe metabolism of Rifampicin can be decreased when combined with Pyrimethamine.Approved, Vet Approved
QuazepamThe metabolism of Quazepam can be increased when combined with Rifampicin.Approved, Illicit
QuercetinThe serum concentration of Rifampicin can be increased when it is combined with Quercetin.Experimental
QuetiapineThe serum concentration of Quetiapine can be decreased when it is combined with Rifampicin.Approved
QuinacrineThe metabolism of Quinacrine can be increased when combined with Rifampicin.Approved
QuinidineThe serum concentration of Quinidine can be decreased when it is combined with Rifampicin.Approved
QuinineThe serum concentration of Quinine can be decreased when it is combined with Rifampicin.Approved
RabeprazoleThe metabolism of Rabeprazole can be increased when combined with Rifampicin.Approved, Investigational
RadicicolThe serum concentration of Rifampicin can be increased when it is combined with Radicicol.Experimental
RaloxifeneThe metabolism of Raloxifene can be increased when combined with Rifampicin.Approved, Investigational
RaltegravirThe serum concentration of Raltegravir can be decreased when it is combined with Rifampicin.Approved
RamelteonThe metabolism of Ramelteon can be increased when combined with Rifampicin.Approved, Investigational
RanitidineThe metabolism of Ranitidine can be increased when combined with Rifampicin.Approved
RanolazineThe serum concentration of Ranolazine can be decreased when it is combined with Rifampicin.Approved, Investigational
RasagilineThe metabolism of Rasagiline can be increased when combined with Rifampicin.Approved
ReboxetineThe metabolism of Reboxetine can be increased when combined with Rifampicin.Approved, Investigational
RegorafenibThe serum concentration of Regorafenib can be decreased when it is combined with Rifampicin.Approved
RepaglinideThe serum concentration of Repaglinide can be decreased when it is combined with Rifampicin.Approved, Investigational
ReserpineThe serum concentration of Reserpine can be decreased when it is combined with Rifampicin.Approved
ResveratrolThe metabolism of Resveratrol can be increased when combined with Rifampicin.Experimental, Investigational
RetapamulinThe metabolism of Retapamulin can be increased when combined with Rifampicin.Approved
RifabutinThe metabolism of Rifampicin can be increased when combined with Rifabutin.Approved
RifapentineThe metabolism of Rifampicin can be increased when combined with Rifapentine.Approved
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Rifampicin.Approved, Investigational
RilpivirineThe serum concentration of Rilpivirine can be decreased when it is combined with Rifampicin.Approved
RiluzoleThe metabolism of Riluzole can be increased when combined with Rifampicin.Approved, Investigational
RimexoloneThe serum concentration of Rimexolone can be decreased when it is combined with Rifampicin.Approved
RimonabantThe metabolism of Rimonabant can be increased when combined with Rifampicin.Approved, Investigational
RiociguatThe metabolism of Riociguat can be increased when combined with Rifampicin.Approved
RisedronateThe serum concentration of Risedronate can be decreased when it is combined with Rifampicin.Approved, Investigational
RisperidoneThe metabolism of Risperidone can be increased when combined with Rifampicin.Approved, Investigational
RitonavirThe serum concentration of Ritonavir can be decreased when it is combined with Rifampicin.Approved, Investigational
RivaroxabanThe serum concentration of Rivaroxaban can be decreased when it is combined with Rifampicin.Approved
RizatriptanThe metabolism of Rizatriptan can be increased when combined with Rifampicin.Approved
RofecoxibThe metabolism of Rofecoxib can be increased when combined with Rifampicin.Investigational, Withdrawn
RoflumilastThe serum concentration of Roflumilast can be decreased when it is combined with Rifampicin.Approved
RolapitantThe serum concentration of Rolapitant can be decreased when it is combined with Rifampicin.Approved
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Rifampicin.Approved, Investigational
RopiniroleThe metabolism of Ropinirole can be increased when combined with Rifampicin.Approved, Investigational
RopivacaineThe metabolism of Ropivacaine can be increased when combined with Rifampicin.Approved
RosiglitazoneThe metabolism of Rosiglitazone can be increased when combined with Rifampicin.Approved, Investigational
RosuvastatinThe metabolism of Rosuvastatin can be increased when combined with Rifampicin.Approved
RotigotineThe metabolism of Rotigotine can be increased when combined with Rifampicin.Approved
RoxithromycinThe metabolism of Roxithromycin can be increased when combined with Rifampicin.Approved, Withdrawn
RuxolitinibThe metabolism of Ruxolitinib can be increased when combined with Rifampicin.Approved
Salicylhydroxamic AcidThe serum concentration of Rifampicin can be increased when it is combined with Salicylhydroxamic Acid.Experimental
Salicylic acidThe metabolism of Salicylic acid can be increased when combined with Rifampicin.Approved, Vet Approved
SalmeterolThe metabolism of Salmeterol can be increased when combined with Rifampicin.Approved
SaquinavirThe risk or severity of adverse effects can be increased when Rifampicin is combined with Saquinavir.Approved, Investigational
SaxagliptinThe serum concentration of Saxagliptin can be decreased when it is combined with Rifampicin.Approved
ScopolamineThe serum concentration of Rifampicin can be increased when it is combined with Scopolamine.Approved
SecobarbitalThe metabolism of Rifampicin can be increased when combined with Secobarbital.Approved, Vet Approved
SelegilineThe metabolism of Selegiline can be increased when combined with Rifampicin.Approved, Investigational, Vet Approved
SelexipagThe metabolism of Selexipag can be increased when combined with Rifampicin.Approved
SeratrodastThe metabolism of Seratrodast can be increased when combined with Rifampicin.Approved, Investigational
SertaconazoleThe serum concentration of Rifampicin can be increased when it is combined with Sertaconazole.Approved
SertindoleThe metabolism of Sertindole can be increased when combined with Rifampicin.Approved, Withdrawn
SertralineThe metabolism of Sertraline can be increased when combined with Rifampicin.Approved
SevofluraneThe metabolism of Sevoflurane can be increased when combined with Rifampicin.Approved, Vet Approved
SibutramineThe metabolism of Sibutramine can be increased when combined with Rifampicin.Approved, Illicit, Investigational, Withdrawn
SildenafilThe metabolism of Sildenafil can be increased when combined with Rifampicin.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Rifampicin.Approved
SiltuximabThe serum concentration of Rifampicin can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Simeprevir can be decreased when it is combined with Rifampicin.Approved
SimvastatinThe metabolism of Simvastatin can be increased when combined with Rifampicin.Approved
SinefunginThe serum concentration of Rifampicin can be increased when it is combined with Sinefungin.Experimental
SirolimusThe metabolism of Sirolimus can be increased when combined with Rifampicin.Approved, Investigational
SitagliptinThe metabolism of Sitagliptin can be increased when combined with Rifampicin.Approved, Investigational
SitaxentanThe metabolism of Sitaxentan can be increased when combined with Rifampicin.Approved, Investigational, Withdrawn
SofosbuvirThe serum concentration of Sofosbuvir can be decreased when it is combined with Rifampicin.Approved
SolifenacinThe metabolism of Solifenacin can be increased when combined with Rifampicin.Approved
SolithromycinThe metabolism of Rifampicin can be decreased when combined with Solithromycin.Investigational
SonidegibThe serum concentration of Sonidegib can be decreased when it is combined with Rifampicin.Approved, Investigational
SorafenibThe serum concentration of Sorafenib can be decreased when it is combined with Rifampicin.Approved, Investigational
SotalolThe serum concentration of Sotalol can be decreased when it is combined with Rifampicin.Approved
SparfloxacinThe serum concentration of Sparfloxacin can be decreased when it is combined with Rifampicin.Approved
SphingosineThe serum concentration of Sphingosine can be decreased when it is combined with Rifampicin.Experimental
SpiramycinThe metabolism of Spiramycin can be increased when combined with Rifampicin.Approved
SpironolactoneThe serum concentration of Rifampicin can be increased when it is combined with Spironolactone.Approved
St. John's WortThe serum concentration of Rifampicin can be decreased when it is combined with St. John's Wort.Nutraceutical
StaurosporineThe serum concentration of Rifampicin can be increased when it is combined with Staurosporine.Experimental
StiripentolThe serum concentration of Rifampicin can be increased when it is combined with Stiripentol.Approved
StreptozocinThe serum concentration of Rifampicin can be decreased when it is combined with Streptozocin.Approved
SufentanilThe metabolism of Sufentanil can be increased when combined with Rifampicin.Approved, Investigational
SulconazoleThe serum concentration of Rifampicin can be increased when it is combined with Sulconazole.Approved
SulfadiazineThe metabolism of Sulfadiazine can be increased when combined with Rifampicin.Approved, Vet Approved
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be increased when combined with Rifampicin.Approved
SulfamoxoleThe metabolism of Sulfamoxole can be increased when combined with Rifampicin.Approved
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be increased when combined with Rifampicin.Approved
SulfisoxazoleThe metabolism of Sulfisoxazole can be increased when combined with Rifampicin.Approved, Vet Approved
SumatriptanThe serum concentration of Rifampicin can be increased when it is combined with Sumatriptan.Approved, Investigational
SunitinibThe serum concentration of Sunitinib can be decreased when it is combined with Rifampicin.Approved, Investigational
SuprofenThe metabolism of Suprofen can be increased when combined with Rifampicin.Approved, Withdrawn
SuvorexantThe serum concentration of Suvorexant can be decreased when it is combined with Rifampicin.Approved
Synthetic Conjugated Estrogens, AThe metabolism of Synthetic Conjugated Estrogens, A can be increased when combined with Rifampicin.Approved
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be increased when combined with Rifampicin.Approved
TacrineThe metabolism of Tacrine can be increased when combined with Rifampicin.Withdrawn
TacrolimusThe metabolism of Tacrolimus can be increased when combined with Rifampicin.Approved, Investigational
TacrolimusThe serum concentration of Tacrolimus can be decreased when it is combined with Rifampicin.Approved, Investigational
TadalafilThe serum concentration of Tadalafil can be decreased when it is combined with Rifampicin.Approved, Investigational
TamoxifenThe metabolism of Tamoxifen can be increased when combined with Rifampicin.Approved
TamsulosinThe metabolism of Tamsulosin can be increased when combined with Rifampicin.Approved, Investigational
TapentadolThe metabolism of Tapentadol can be increased when combined with Rifampicin.Approved
TasimelteonThe serum concentration of Tasimelteon can be decreased when it is combined with Rifampicin.Approved
TasosartanThe metabolism of Tasosartan can be increased when combined with Rifampicin.Approved
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be increased when combined with Rifampicin.Experimental
Taurocholic AcidThe serum concentration of Taurocholic Acid can be decreased when it is combined with Rifampicin.Experimental
TavaboroleThe serum concentration of Rifampicin can be increased when it is combined with Tavaborole.Approved
TazaroteneThe metabolism of Tazarotene can be increased when combined with Rifampicin.Approved, Investigational
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Rifampicin.Approved
TelaprevirThe serum concentration of Telaprevir can be decreased when it is combined with Rifampicin.Approved
TelithromycinThe metabolism of Telithromycin can be increased when combined with Rifampicin.Approved
TelmisartanThe serum concentration of Rifampicin can be increased when it is combined with Telmisartan.Approved, Investigational
TemafloxacinThe metabolism of Temafloxacin can be increased when combined with Rifampicin.Withdrawn
TemazepamThe metabolism of Temazepam can be increased when combined with Rifampicin.Approved
TemsirolimusThe serum concentration of Temsirolimus can be decreased when it is combined with Rifampicin.Approved
TeniposideThe metabolism of Teniposide can be increased when combined with Rifampicin.Approved
TenoxicamThe metabolism of Tenoxicam can be increased when combined with Rifampicin.Approved
TerazosinThe serum concentration of Rifampicin can be increased when it is combined with Terazosin.Approved
TerbinafineThe metabolism of Terbinafine can be increased when combined with Rifampicin.Approved, Investigational, Vet Approved
TerbinafineThe serum concentration of Terbinafine can be decreased when it is combined with Rifampicin.Approved, Investigational, Vet Approved
TerconazoleThe serum concentration of Rifampicin can be increased when it is combined with Terconazole.Approved
TerfenadineThe metabolism of Terfenadine can be increased when combined with Rifampicin.Withdrawn
TeriflunomideThe metabolism of Rifampicin can be decreased when combined with Teriflunomide.Approved
TesmilifeneThe metabolism of Tesmilifene can be increased when combined with Rifampicin.Investigational
TestosteroneThe metabolism of Testosterone can be increased when combined with Rifampicin.Approved, Investigational
TetracyclineThe metabolism of Tetracycline can be increased when combined with Rifampicin.Approved, Vet Approved
ThalidomideThe metabolism of Thalidomide can be increased when combined with Rifampicin.Approved, Investigational, Withdrawn
TheobromineThe metabolism of Theobromine can be increased when combined with Rifampicin.Approved
TheophyllineThe metabolism of Theophylline can be increased when combined with Rifampicin.Approved
ThiabendazoleThe metabolism of Thiabendazole can be increased when combined with Rifampicin.Approved, Vet Approved
ThiamylalThe metabolism of Thiamylal can be increased when combined with Rifampicin.Approved, Vet Approved
ThiopentalThe metabolism of Thiopental can be increased when combined with Rifampicin.Approved, Vet Approved
ThioridazineThe metabolism of Thioridazine can be increased when combined with Rifampicin.Approved
ThiotepaThe metabolism of Thiotepa can be increased when combined with Rifampicin.Approved
ThiothixeneThe metabolism of Thiothixene can be increased when combined with Rifampicin.Approved
ThymolThe serum concentration of Rifampicin can be increased when it is combined with Thymol.Approved
Thyroid, porcineThe serum concentration of Thyroid, porcine can be decreased when it is combined with Rifampicin.Approved
TiagabineThe metabolism of Tiagabine can be increased when combined with Rifampicin.Approved
TicagrelorThe serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with Rifampicin resulting in a loss in efficacy.Approved
TiclopidineThe metabolism of Ticlopidine can be increased when combined with Rifampicin.Approved
TimololThe metabolism of Timolol can be increased when combined with Rifampicin.Approved
TinidazoleThe metabolism of Tinidazole can be increased when combined with Rifampicin.Approved, Investigational
TioconazoleThe serum concentration of Rifampicin can be increased when it is combined with Tioconazole.Approved
TiotropiumThe metabolism of Tiotropium can be increased when combined with Rifampicin.Approved
TipranavirThe serum concentration of Tipranavir can be decreased when it is combined with Rifampicin.Approved, Investigational
TixocortolThe serum concentration of Tixocortol can be decreased when it is combined with Rifampicin.Approved
TizanidineThe metabolism of Tizanidine can be increased when combined with Rifampicin.Approved
TocilizumabThe serum concentration of Rifampicin can be decreased when it is combined with Tocilizumab.Approved
TofacitinibThe serum concentration of Tofacitinib can be decreased when it is combined with Rifampicin.Approved, Investigational
TolazamideThe serum concentration of Tolazamide can be decreased when it is combined with Rifampicin.Approved
TolbutamideThe serum concentration of Tolbutamide can be decreased when it is combined with Rifampicin.Approved
Tolfenamic AcidThe serum concentration of Tolfenamic Acid can be decreased when it is combined with Rifampicin.Approved
TolnaftateThe serum concentration of Rifampicin can be increased when it is combined with Tolnaftate.Approved, Vet Approved
TolterodineThe metabolism of Tolterodine can be increased when combined with Rifampicin.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be decreased when it is combined with Rifampicin.Approved
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Rifampicin.Approved, Investigational
TorasemideThe metabolism of Torasemide can be increased when combined with Rifampicin.Approved
ToremifeneThe serum concentration of Toremifene can be decreased when it is combined with Rifampicin.Approved, Investigational
TrabectedinThe serum concentration of Trabectedin can be decreased when it is combined with Rifampicin.Approved, Investigational
TramadolThe metabolism of Tramadol can be increased when combined with Rifampicin.Approved, Investigational
TranilastThe serum concentration of Tranilast can be decreased when it is combined with Rifampicin.Approved, Investigational
Trastuzumab emtansineThe metabolism of Trastuzumab emtansine can be increased when combined with Rifampicin.Approved
TrazodoneThe metabolism of Trazodone can be increased when combined with Rifampicin.Approved, Investigational
TreprostinilThe serum concentration of Treprostinil can be decreased when it is combined with Rifampicin.Approved, Investigational
TretinoinThe metabolism of Tretinoin can be increased when combined with Rifampicin.Approved, Investigational, Nutraceutical
TriamcinoloneThe metabolism of Triamcinolone can be increased when combined with Rifampicin.Approved, Vet Approved
TriamtereneThe metabolism of Triamterene can be increased when combined with Rifampicin.Approved
TriazolamThe metabolism of Triazolam can be increased when combined with Rifampicin.Approved
TrifluoperazineThe metabolism of Trifluoperazine can be increased when combined with Rifampicin.Approved
TriflupromazineThe serum concentration of Rifampicin can be increased when it is combined with Triflupromazine.Approved, Vet Approved
TrimethadioneThe metabolism of Trimethadione can be increased when combined with Rifampicin.Approved
TrimethoprimThe metabolism of Trimethoprim can be increased when combined with Rifampicin.Approved, Vet Approved
TrimetrexateThe serum concentration of Rifampicin can be increased when it is combined with Trimetrexate.Approved, Investigational
TrimipramineThe metabolism of Trimipramine can be increased when combined with Rifampicin.Approved
TroglitazoneThe metabolism of Troglitazone can be increased when combined with Rifampicin.Withdrawn
TroleandomycinThe metabolism of Troleandomycin can be increased when combined with Rifampicin.Approved
TylosinThe metabolism of Rifampicin can be decreased when combined with Tylosin.Vet Approved
UdenafilThe metabolism of Udenafil can be increased when combined with Rifampicin.Approved, Investigational
UlipristalThe serum concentration of Ulipristal can be decreased when it is combined with Rifampicin.Approved
UmeclidiniumThe serum concentration of Umeclidinium can be decreased when it is combined with Rifampicin.Approved
ValdecoxibThe metabolism of Valdecoxib can be increased when combined with Rifampicin.Investigational, Withdrawn
Valproic AcidThe serum concentration of Valproic Acid can be decreased when it is combined with Rifampicin.Approved, Investigational
ValsartanThe metabolism of Valsartan can be increased when combined with Rifampicin.Approved, Investigational
VandetanibThe serum concentration of Vandetanib can be decreased when it is combined with Rifampicin.Approved
VanoxerineThe metabolism of Vanoxerine can be increased when combined with Rifampicin.Investigational
VardenafilThe metabolism of Vardenafil can be increased when combined with Rifampicin.Approved
VecuroniumThe serum concentration of Vecuronium can be decreased when it is combined with Rifampicin.Approved
VemurafenibThe serum concentration of Vemurafenib can be decreased when it is combined with Rifampicin.Approved
VenetoclaxThe metabolism of Venetoclax can be increased when combined with Rifampicin.Approved
VenlafaxineThe metabolism of Venlafaxine can be increased when combined with Rifampicin.Approved
VerapamilThe metabolism of Verapamil can be increased when combined with Rifampicin.Approved
VicrivirocThe metabolism of Vicriviroc can be increased when combined with Rifampicin.Investigational
VilanterolThe metabolism of Vilanterol can be increased when combined with Rifampicin.Approved
VilazodoneThe serum concentration of Vilazodone can be decreased when it is combined with Rifampicin.Approved
VinblastineThe metabolism of Vinblastine can be increased when combined with Rifampicin.Approved
VincristineThe serum concentration of Vincristine can be decreased when it is combined with Rifampicin.Approved, Investigational
VincristineThe metabolism of Vincristine can be increased when combined with Rifampicin.Approved, Investigational
VindesineThe metabolism of Vindesine can be increased when combined with Rifampicin.Approved
VinorelbineThe metabolism of Vinorelbine can be increased when combined with Rifampicin.Approved, Investigational
VinpocetineThe serum concentration of Vinpocetine can be decreased when it is combined with Rifampicin.Investigational
VismodegibThe metabolism of Vismodegib can be increased when combined with Rifampicin.Approved
VorapaxarThe serum concentration of Vorapaxar can be decreased when it is combined with Rifampicin.Approved
VoriconazoleThe serum concentration of Rifampicin can be increased when it is combined with Voriconazole.Approved, Investigational
VortioxetineThe serum concentration of Vortioxetine can be decreased when it is combined with Rifampicin.Approved
WarfarinThe metabolism of Warfarin can be increased when combined with Rifampicin.Approved
XimelagatranThe metabolism of Ximelagatran can be increased when combined with Rifampicin.Approved, Investigational, Withdrawn
XylometazolineThe serum concentration of Xylometazoline can be decreased when it is combined with Rifampicin.Approved
YohimbineThe metabolism of Yohimbine can be increased when combined with Rifampicin.Approved, Vet Approved
ZafirlukastThe metabolism of Zafirlukast can be increased when combined with Rifampicin.Approved, Investigational
ZalcitabineThe metabolism of Zalcitabine can be increased when combined with Rifampicin.Approved
ZaleplonThe serum concentration of Zaleplon can be decreased when it is combined with Rifampicin.Approved, Illicit, Investigational
ZaltoprofenThe metabolism of Zaltoprofen can be increased when combined with Rifampicin.Approved
ZiconotideThe serum concentration of Ziconotide can be decreased when it is combined with Rifampicin.Approved
ZidovudineThe serum concentration of Zidovudine can be decreased when it is combined with Rifampicin.Approved
ZileutonThe metabolism of Zileuton can be increased when combined with Rifampicin.Approved, Investigational, Withdrawn
ZimelidineThe serum concentration of Rifampicin can be increased when it is combined with Zimelidine.Withdrawn
ZiprasidoneThe metabolism of Ziprasidone can be increased when combined with Rifampicin.Approved
ZolmitriptanThe metabolism of Zolmitriptan can be increased when combined with Rifampicin.Approved, Investigational
ZolpidemThe serum concentration of Zolpidem can be decreased when it is combined with Rifampicin.Approved
ZomepiracThe metabolism of Zomepirac can be increased when combined with Rifampicin.Withdrawn
ZonisamideThe metabolism of Zonisamide can be increased when combined with Rifampicin.Approved, Investigational
ZopicloneThe metabolism of Zopiclone can be increased when combined with Rifampicin.Approved
ZuclopenthixolThe serum concentration of Zuclopenthixol can be decreased when it is combined with Rifampicin.Approved, Investigational
Food Interactions
  • Avoid alcohol.
  • Take on empty stomach: 1 hour before or 2 hours after meals.
  • Take with a full glass of water.
References
Synthesis Reference

Klaus Jurgen, Joachim Seydel, “Combination preparations containing rifampicin and thioacetazon.” U.S. Patent US5104875, issued August, 1973.

US5104875
General References
  1. Baysarowich J, Koteva K, Hughes DW, Ejim L, Griffiths E, Zhang K, Junop M, Wright GD: Rifamycin antibiotic resistance by ADP-ribosylation: Structure and diversity of Arr. Proc Natl Acad Sci U S A. 2008 Mar 25;105(12):4886-91. doi: 10.1073/pnas.0711939105. Epub 2008 Mar 18. [PubMed:18349144 ]
External Links
ATC CodesJ04AM02J04AM06J04AB02J04AM05
AHFS Codes
  • 08:16.04
PDB Entries
FDA labelDownload (43.3 KB)
MSDSDownload (86.7 KB)
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.5553
Blood Brain Barrier-0.974
Caco-2 permeable-0.7123
P-glycoprotein substrateSubstrate0.9308
P-glycoprotein inhibitor IInhibitor0.8564
P-glycoprotein inhibitor IINon-inhibitor0.6049
Renal organic cation transporterNon-inhibitor0.8178
CYP450 2C9 substrateNon-substrate0.8508
CYP450 2D6 substrateNon-substrate0.9115
CYP450 3A4 substrateSubstrate0.7296
CYP450 1A2 substrateNon-inhibitor0.9045
CYP450 2C9 inhibitorNon-inhibitor0.907
CYP450 2D6 inhibitorNon-inhibitor0.9231
CYP450 2C19 inhibitorNon-inhibitor0.9025
CYP450 3A4 inhibitorNon-inhibitor0.8432
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9099
Ames testNon AMES toxic0.5803
CarcinogenicityNon-carcinogens0.8493
BiodegradationNot ready biodegradable0.9962
Rat acute toxicity2.6875 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.908
hERG inhibition (predictor II)Non-inhibitor0.5486
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
CapsuleOral
CapsuleOral150 mg
CapsuleOral300 mg
CapsuleOral150 mg/1
CapsuleOral300 mg/1
Capsule, coatedOral300 mg/1
Injection, powder, lyophilized, for solutionIntravenous600 mg/10mL
Injection, powder, lyophilized, for solutionIntravenous600 mg/1
TabletOral
Tablet, sugar coatedOral
Prices
Unit descriptionCostUnit
Rifadin iv 600 mg vial140.9USD vial
Rifampin iv 600 mg vial136.3USD vial
Rifampin crystals6.72USD g
Rifampin powder3.98USD g
Rifadin 300 mg capsule3.09USD capsule
Rifadin 150 mg capsule2.57USD capsule
Rifampin 300 mg capsule2.37USD capsule
Rimactane 300 mg capsule2.35USD capsule
Rifampin 150 mg capsule2.27USD capsule
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point183 °CNot Available
water solubility1400 mg/L (at 25 °C)YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP2.7Not Available
pKa1.7SANGSTER (2004)
Predicted Properties
PropertyValueSource
Water Solubility0.0413 mg/mLALOGPS
logP3.85ALOGPS
logP2.77ChemAxon
logS-4.3ALOGPS
pKa (Strongest Acidic)6.9ChemAxon
pKa (Strongest Basic)7.53ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count14ChemAxon
Hydrogen Donor Count6ChemAxon
Polar Surface Area220.15 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity225.58 m3·mol-1ChemAxon
Polarizability86.46 Å3ChemAxon
Number of Rings5ChemAxon
Bioavailability0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
Taxonomy
ClassificationNot classified

Targets

Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
yes
Actions
inhibitor
General Function:
Ribonucleoside binding
Specific Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Gene Name:
rpoB
Uniprot ID:
P0A8V2
Molecular Weight:
150631.165 Da
References
  1. Villain-Guillot P, Bastide L, Gualtieri M, Leonetti JP: Progress in targeting bacterial transcription. Drug Discov Today. 2007 Mar;12(5-6):200-8. Epub 2007 Feb 5. [PubMed:17331884 ]
  2. White RJ, Lancini GC, Silvestri LG: Mechanism of action of rifampin on Mycobacterium smegmatis. J Bacteriol. 1971 Nov;108(2):737-41. [PubMed:4942761 ]
  3. Tupin A, Gualtieri M, Roquet-Baneres F, Morichaud Z, Brodolin K, Leonetti JP: Resistance to rifampicin: at the crossroads between ecological, genomic and medical concerns. Int J Antimicrob Agents. 2010 Jun;35(6):519-23. doi: 10.1016/j.ijantimicag.2009.12.017. Epub 2010 Feb 24. [PubMed:20185278 ]
  4. Campbell EA, Korzheva N, Mustaev A, Murakami K, Nair S, Goldfarb A, Darst SA: Structural mechanism for rifampicin inhibition of bacterial rna polymerase. Cell. 2001 Mar 23;104(6):901-12. [PubMed:11290327 ]
  5. Wehrli W: Rifampin: mechanisms of action and resistance. Rev Infect Dis. 1983 Jul-Aug;5 Suppl 3:S407-11. [PubMed:6356275 ]
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
yes
Actions
inhibitor
General Function:
Dna-directed rna polymerase activity
Specific Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Gene Name:
rpoC
Uniprot ID:
P0A8T7
Molecular Weight:
155158.84 Da
References
  1. Villain-Guillot P, Bastide L, Gualtieri M, Leonetti JP: Progress in targeting bacterial transcription. Drug Discov Today. 2007 Mar;12(5-6):200-8. Epub 2007 Feb 5. [PubMed:17331884 ]
  2. White RJ, Lancini GC, Silvestri LG: Mechanism of action of rifampin on Mycobacterium smegmatis. J Bacteriol. 1971 Nov;108(2):737-41. [PubMed:4942761 ]
  3. Tupin A, Gualtieri M, Roquet-Baneres F, Morichaud Z, Brodolin K, Leonetti JP: Resistance to rifampicin: at the crossroads between ecological, genomic and medical concerns. Int J Antimicrob Agents. 2010 Jun;35(6):519-23. doi: 10.1016/j.ijantimicag.2009.12.017. Epub 2010 Feb 24. [PubMed:20185278 ]
  4. Campbell EA, Korzheva N, Mustaev A, Murakami K, Nair S, Goldfarb A, Darst SA: Structural mechanism for rifampicin inhibition of bacterial rna polymerase. Cell. 2001 Mar 23;104(6):901-12. [PubMed:11290327 ]
  5. Wehrli W: Rifampin: mechanisms of action and resistance. Rev Infect Dis. 1983 Jul-Aug;5 Suppl 3:S407-11. [PubMed:6356275 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
agonist
General Function:
Zinc ion binding
Specific Function:
Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and is...
Gene Name:
NR1I2
Uniprot ID:
O75469
Molecular Weight:
49761.245 Da
References
  1. Chen J, Raymond K: Roles of rifampicin in drug-drug interactions: underlying molecular mechanisms involving the nuclear pregnane X receptor. Ann Clin Microbiol Antimicrob. 2006 Feb 15;5:3. [PubMed:16480505 ]
  2. Cheng J, Ma X, Krausz KW, Idle JR, Gonzalez FJ: Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance acetaminophen-induced toxicity. Drug Metab Dispos. 2009 Aug;37(8):1611-21. doi: 10.1124/dmd.109.027565. Epub 2009 May 21. [PubMed:19460945 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver.
Gene Name:
SLCO1B1
Uniprot ID:
Q9Y6L6
Molecular Weight:
76447.99 Da
References
  1. Vavricka SR, Van Montfoort J, Ha HR, Meier PJ, Fattinger K: Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver. Hepatology. 2002 Jul;36(1):164-72. [PubMed:12085361 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin.
Gene Name:
SLCO1A2
Uniprot ID:
P46721
Molecular Weight:
74144.105 Da
References
  1. Vavricka SR, Van Montfoort J, Ha HR, Meier PJ, Fattinger K: Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver. Hepatology. 2002 Jul;36(1):164-72. [PubMed:12085361 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver.
Gene Name:
SLCO1B3
Uniprot ID:
Q9NPD5
Molecular Weight:
77402.175 Da
References
  1. Vavricka SR, Van Montfoort J, Ha HR, Meier PJ, Fattinger K: Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver. Hepatology. 2002 Jul;36(1):164-72. [PubMed:12085361 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Sterol 14-demethylase activity
Specific Function:
Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.
Gene Name:
CYP51A1
Uniprot ID:
Q16850
Molecular Weight:
56805.26 Da
References
  1. Ekins S, Mankowski DC, Hoover DJ, Lawton MP, Treadway JL, Harwood HJ Jr: Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors. Drug Metab Dispos. 2007 Mar;35(3):493-500. Epub 2006 Dec 28. [PubMed:17194716 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Toxic substance binding
Specific Function:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.
Gene Name:
ALB
Uniprot ID:
P02768
Molecular Weight:
69365.94 Da
References
  1. Baneres-Roquet F, Gualtieri M, Villain-Guillot P, Pugniere M, Leonetti JP: Use of a surface plasmon resonance method to investigate antibiotic and plasma protein interactions. Antimicrob Agents Chemother. 2009 Apr;53(4):1528-31. doi: 10.1128/AAC.00971-08. Epub 2009 Jan 21. [PubMed:19164148 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost.
Gene Name:
SLCO2B1
Uniprot ID:
O94956
Molecular Weight:
76709.98 Da
References
  1. Karlgren M, Vildhede A, Norinder U, Wisniewski JR, Kimoto E, Lai Y, Haglund U, Artursson P: Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. J Med Chem. 2012 May 24;55(10):4740-63. doi: 10.1021/jm300212s. Epub 2012 May 15. [PubMed:22541068 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinducer
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Dixit V, Hariparsad N, Li F, Desai P, Thummel KE, Unadkat JD: Cytochrome P450 enzymes and transporters induced by anti-human immunodeficiency virus protease inhibitors in human hepatocytes: implications for predicting clinical drug interactions. Drug Metab Dispos. 2007 Oct;35(10):1853-9. Epub 2007 Jul 16. [PubMed:17639026 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitorinducer
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme...
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular Weight:
55824.275 Da
References
  1. Dixit V, Hariparsad N, Li F, Desai P, Thummel KE, Unadkat JD: Cytochrome P450 enzymes and transporters induced by anti-human immunodeficiency virus protease inhibitors in human hepatocytes: implications for predicting clinical drug interactions. Drug Metab Dispos. 2007 Oct;35(10):1853-9. Epub 2007 Jul 16. [PubMed:17639026 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Steroid binding
Specific Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4-methylumbelliferone, 1-naph...
Gene Name:
UGT1A1
Uniprot ID:
P22309
Molecular Weight:
59590.91 Da
References
  1. Ellis E, Wagner M, Lammert F, Nemeth A, Gumhold J, Strassburg CP, Kylander C, Katsika D, Trauner M, Einarsson C, Marschall HU: Successful treatment of severe unconjugated hyperbilirubinemia via induction of UGT1A1 by rifampicin. J Hepatol. 2006 Jan;44(1):243-5. Epub 2005 Oct 27. [PubMed:16288819 ]
  2. Jemnitz K, Lengyel G, Vereczkey L: In vitro induction of bilirubin conjugation in primary rat hepatocyte culture. Biochem Biophys Res Commun. 2002 Feb 15;291(1):29-33. [PubMed:11829457 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinducer
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Dixit V, Hariparsad N, Li F, Desai P, Thummel KE, Unadkat JD: Cytochrome P450 enzymes and transporters induced by anti-human immunodeficiency virus protease inhibitors in human hepatocytes: implications for predicting clinical drug interactions. Drug Metab Dispos. 2007 Oct;35(10):1853-9. Epub 2007 Jul 16. [PubMed:17639026 ]
  3. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Gene Name:
CYP2B6
Uniprot ID:
P20813
Molecular Weight:
56277.81 Da
References
  1. Dixit V, Hariparsad N, Li F, Desai P, Thummel KE, Unadkat JD: Cytochrome P450 enzymes and transporters induced by anti-human immunodeficiency virus protease inhibitors in human hepatocytes: implications for predicting clinical drug interactions. Drug Metab Dispos. 2007 Oct;35(10):1853-9. Epub 2007 Jul 16. [PubMed:17639026 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitorinducer
General Function:
Steroid hydroxylase activity
Specific Function:
Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity.
Gene Name:
CYP2A6
Uniprot ID:
P11509
Molecular Weight:
56501.005 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Steroid hydroxylase activity
Specific Function:
Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
Gene Name:
CYP2E1
Uniprot ID:
P05181
Molecular Weight:
56848.42 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Monooxygenase activity
Specific Function:
Exhibits low testosterone 6-beta-hydroxylase activity.
Gene Name:
CYP3A43
Uniprot ID:
Q9HB55
Molecular Weight:
57669.21 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A5
Uniprot ID:
P20815
Molecular Weight:
57108.065 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A7
Uniprot ID:
P24462
Molecular Weight:
57525.03 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Leukotriene-b4 20-monooxygenase activity
Specific Function:
Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate, myristate and palmitate. Has little activity toward prostaglandins A1 and E1. Oxidizes arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE).
Gene Name:
CYP4A11
Uniprot ID:
Q02928
Molecular Weight:
59347.31 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitorinducer
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Geick A, Eichelbaum M, Burk O: Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin. J Biol Chem. 2001 May 4;276(18):14581-7. Epub 2001 Jan 31. [PubMed:11297522 ]
  2. Schuetz EG, Beck WT, Schuetz JD: Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells. Mol Pharmacol. 1996 Feb;49(2):311-8. [PubMed:8632764 ]
  3. Greiner B, Eichelbaum M, Fritz P, Kreichgauer HP, von Richter O, Zundler J, Kroemer HK: The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin. J Clin Invest. 1999 Jul;104(2):147-53. [PubMed:10411543 ]
  4. Fardel O, Lecureur V, Loyer P, Guillouzo A: Rifampicin enhances anti-cancer drug accumulation and activity in multidrug-resistant cells. Biochem Pharmacol. 1995 May 11;49(9):1255-60. [PubMed:7763306 ]
  5. Collett A, Tanianis-Hughes J, Hallifax D, Warhurst G: Predicting P-glycoprotein effects on oral absorption: correlation of transport in Caco-2 with drug pharmacokinetics in wild-type and mdr1a(-/-) mice in vivo. Pharm Res. 2004 May;21(5):819-26. [PubMed:15180340 ]
  6. Kuypers DR, Verleden G, Naesens M, Vanrenterghem Y: Drug interaction between mycophenolate mofetil and rifampin: possible induction of uridine diphosphate-glucuronosyltransferase. Clin Pharmacol Ther. 2005 Jul;78(1):81-8. [PubMed:16003296 ]
  7. Gurley BJ, Barone GW, Williams DK, Carrier J, Breen P, Yates CR, Song PF, Hubbard MA, Tong Y, Cheboyina S: Effect of milk thistle (Silybum marianum) and black cohosh (Cimicifuga racemosa) supplementation on digoxin pharmacokinetics in humans. Drug Metab Dispos. 2006 Jan;34(1):69-74. Epub 2005 Oct 12. [PubMed:16221754 ]
  8. Chen J, Raymond K: Roles of rifampicin in drug-drug interactions: underlying molecular mechanisms involving the nuclear pregnane X receptor. Ann Clin Microbiol Antimicrob. 2006 Feb 15;5:3. [PubMed:16480505 ]
  9. Lamba J, Strom S, Venkataramanan R, Thummel KE, Lin YS, Liu W, Cheng C, Lamba V, Watkins PB, Schuetz E: MDR1 genotype is associated with hepatic cytochrome P450 3A4 basal and induction phenotype. Clin Pharmacol Ther. 2006 Apr;79(4):325-38. Epub 2006 Feb 20. [PubMed:16580901 ]
  10. Huang R, Murry DJ, Kolwankar D, Hall SD, Foster DR: Vincristine transcriptional regulation of efflux drug transporters in carcinoma cell lines. Biochem Pharmacol. 2006 Jun 14;71(12):1695-704. Epub 2006 Apr 18. [PubMed:16620787 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver.
Gene Name:
SLCO1B3
Uniprot ID:
Q9NPD5
Molecular Weight:
77402.175 Da
References
  1. Cui Y, Konig J, Leier I, Buchholz U, Keppler D: Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6. J Biol Chem. 2001 Mar 30;276(13):9626-30. Epub 2000 Dec 27. [PubMed:11134001 ]
  2. Vavricka SR, Van Montfoort J, Ha HR, Meier PJ, Fattinger K: Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver. Hepatology. 2002 Jul;36(1):164-72. [PubMed:12085361 ]
  3. Cui Y, Konig J, Keppler D: Vectorial transport by double-transfected cells expressing the human uptake transporter SLC21A8 and the apical export pump ABCC2. Mol Pharmacol. 2001 Nov;60(5):934-43. [PubMed:11641421 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Transporter activity
Specific Function:
Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.
Gene Name:
ABCC1
Uniprot ID:
P33527
Molecular Weight:
171589.5 Da
References
  1. Courtois A, Payen L, Vernhet L, de Vries EG, Guillouzo A, Fardel O: Inhibition of multidrug resistance-associated protein (MRP) activity by rifampicin in human multidrug-resistant lung tumor cells. Cancer Lett. 1999 May 3;139(1):97-104. [PubMed:10408915 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost.
Gene Name:
SLCO2B1
Uniprot ID:
O94956
Molecular Weight:
76709.98 Da
References
  1. Vavricka SR, Van Montfoort J, Ha HR, Meier PJ, Fattinger K: Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver. Hepatology. 2002 Jul;36(1):164-72. [PubMed:12085361 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Transporter activity
Specific Function:
Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.
Gene Name:
ABCB11
Uniprot ID:
O95342
Molecular Weight:
146405.83 Da
References
  1. Byrne JA, Strautnieks SS, Mieli-Vergani G, Higgins CF, Linton KJ, Thompson RJ: The human bile salt export pump: characterization of substrate specificity and identification of inhibitors. Gastroenterology. 2002 Nov;123(5):1649-58. [PubMed:12404239 ]
  2. Wang EJ, Casciano CN, Clement RP, Johnson WW: Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites. Pharm Res. 2003 Apr;20(4):537-44. [PubMed:12739759 ]
  3. Noe J, Hagenbuch B, Meier PJ, St-Pierre MV: Characterization of the mouse bile salt export pump overexpressed in the baculovirus system. Hepatology. 2001 May;33(5):1223-31. [PubMed:11343252 ]
  4. Stieger B, Fattinger K, Madon J, Kullak-Ublick GA, Meier PJ: Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver. Gastroenterology. 2000 Feb;118(2):422-30. [PubMed:10648470 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin.
Gene Name:
SLCO1A2
Uniprot ID:
P46721
Molecular Weight:
74144.105 Da
References
  1. Vavricka SR, Van Montfoort J, Ha HR, Meier PJ, Fattinger K: Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver. Hepatology. 2002 Jul;36(1):164-72. [PubMed:12085361 ]
  2. Fattinger K, Cattori V, Hagenbuch B, Meier PJ, Stieger B: Rifamycin SV and rifampicin exhibit differential inhibition of the hepatic rat organic anion transporting polypeptides, Oatp1 and Oatp2. Hepatology. 2000 Jul;32(1):82-6. [PubMed:10869292 ]
  3. Shitara Y, Sugiyama D, Kusuhara H, Kato Y, Abe T, Meier PJ, Itoh T, Sugiyama Y: Comparative inhibitory effects of different compounds on rat oatpl (slc21a1)- and Oatp2 (Slc21a5)-mediated transport. Pharm Res. 2002 Feb;19(2):147-53. [PubMed:11883641 ]
  4. van Montfoort JE, Stieger B, Meijer DK, Weinmann HJ, Meier PJ, Fattinger KE: Hepatic uptake of the magnetic resonance imaging contrast agent gadoxetate by the organic anion transporting polypeptide Oatp1. J Pharmacol Exp Ther. 1999 Jul;290(1):153-7. [PubMed:10381771 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate.
Gene Name:
SLC22A7
Uniprot ID:
Q9Y694
Molecular Weight:
60025.025 Da
References
  1. Sekine T, Cha SH, Tsuda M, Apiwattanakul N, Nakajima N, Kanai Y, Endou H: Identification of multispecific organic anion transporter 2 expressed predominantly in the liver. FEBS Lett. 1998 Jun 12;429(2):179-82. [PubMed:9650585 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver.
Gene Name:
SLCO1B1
Uniprot ID:
Q9Y6L6
Molecular Weight:
76447.99 Da
References
  1. Cui Y, Konig J, Leier I, Buchholz U, Keppler D: Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6. J Biol Chem. 2001 Mar 30;276(13):9626-30. Epub 2000 Dec 27. [PubMed:11134001 ]
  2. Vavricka SR, Van Montfoort J, Ha HR, Meier PJ, Fattinger K: Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver. Hepatology. 2002 Jul;36(1):164-72. [PubMed:12085361 ]
  3. Tirona RG, Leake BF, Wolkoff AW, Kim RB: Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation. J Pharmacol Exp Ther. 2003 Jan;304(1):223-8. [PubMed:12490595 ]
  4. Sharma P, Holmes VE, Elsby R, Lambert C, Surry D: Validation of cell-based OATP1B1 assays to assess drug transport and the potential for drug-drug interaction to support regulatory submissions. Xenobiotica. 2010 Jan;40(1):24-37. doi: 10.3109/00498250903351013. [PubMed:19919292 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Organic anion transmembrane transporter activity
Specific Function:
Acts as a multispecific organic anion pump which can transport nucleotide analogs.
Gene Name:
ABCC5
Uniprot ID:
O15440
Molecular Weight:
160658.8 Da
References
  1. Schrenk D, Baus PR, Ermel N, Klein C, Vorderstemann B, Kauffmann HM: Up-regulation of transporters of the MRP family by drugs and toxins. Toxicol Lett. 2001 Mar 31;120(1-3):51-7. [PubMed:11323161 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Organic anion transmembrane transporter activity
Specific Function:
Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.
Gene Name:
ABCC2
Uniprot ID:
Q92887
Molecular Weight:
174205.64 Da
References
  1. Kauffmann HM, Pfannschmidt S, Zoller H, Benz A, Vorderstemann B, Webster JI, Schrenk D: Influence of redox-active compounds and PXR-activators on human MRP1 and MRP2 gene expression. Toxicology. 2002 Feb 28;171(2-3):137-46. [PubMed:11836020 ]
  2. Fromm MF, Kauffmann HM, Fritz P, Burk O, Kroemer HK, Warzok RW, Eichelbaum M, Siegmund W, Schrenk D: The effect of rifampin treatment on intestinal expression of human MRP transporters. Am J Pathol. 2000 Nov;157(5):1575-80. [PubMed:11073816 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Organic anion transmembrane transporter activity
Specific Function:
May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity).
Gene Name:
ABCC3
Uniprot ID:
O15438
Molecular Weight:
169341.14 Da
References
  1. Teng S, Jekerle V, Piquette-Miller M: Induction of ABCC3 (MRP3) by pregnane X receptor activators. Drug Metab Dispos. 2003 Nov;31(11):1296-9. [PubMed:14570758 ]
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Drug created on June 13, 2005 07:24 / Updated on November 02, 2016 15:48