Identification

Name
Rifampicin
Accession Number
DB01045  (APRD00207, EXPT02777)
Type
Small Molecule
Groups
Approved
Description

A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)

Structure
Thumb
Synonyms
  • 3-(((4-Methyl-1-piperazinyl)imino)methyl)rifamycin SV
  • RFP
  • Rifampicina
  • Rifampicinum
  • Rifampin
External IDs
BA-41166/E / L-5103 LEPETIT / NIH-10782 / NSC-113926 / NSC-113926-
Product Ingredients
IngredientUNIICASInChI Key
Rifampicin sodiumGPE7477YEK38776-75-9PPGHYTPFGILTSZ-LGIBZRBQSA-M
Product Images
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
RifadinCapsule150 mgOralSanofi Aventis1995-12-31Not applicableCanada
RifadinCapsule300 mg/1OralSanofi Aventis1971-05-21Not applicableUs
RifadinCapsule300 mgOralSanofi Aventis1995-12-31Not applicableCanada
RifadinCapsule150 mg/1OralSanofi Aventis1981-07-15Not applicableUs
Rifadin Cap 300mgCapsule300 mgOralMerrell Dow Pharmaceuticals (Canada) Inc., Division Of Mmdc1988-12-311996-09-09Canada
Rifadin IVInjection, powder, lyophilized, for solution600 mg/10mLIntravenousSanofi Aventis1989-05-25Not applicableUs
Rifadin IV NOVAPLUSInjection, powder, lyophilized, for solution600 mg/10mLIntravenousSanofi Aventis2017-02-01Not applicableUs
Rofact 150mgCapsule150 mgOralValeant Canada Lp Valeant Canada S.E.C.1977-12-31Not applicableCanada
Rofact 300mgCapsule300 mgOralValeant Canada Lp Valeant Canada S.E.C.1977-12-31Not applicableCanada
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
RifampinCapsule300 mg/1OralCentral Texas Community Health Centers2001-07-01Not applicableUs
RifampinCapsule150 mg/1OralVersa Pharm Incorporated2001-07-01Not applicableUs
RifampinCapsule300 mg/1OralLupin Pharmaceuticals2013-10-28Not applicableUs
RifampinCapsule300 mg/1OralRemedy Repack2007-04-032016-11-30Us
RifampinInjection, powder, lyophilized, for solution600 mg/10mLIntravenousHeritage2014-08-18Not applicableUs
RifampinCapsule300 mg/1OralLannett Company, Inc.2008-04-20Not applicableUs
RifampinCapsule300 mg/1OralPhysicians Total Care, Inc.2008-04-20Not applicableUs
RifampinCapsule300 mg/1OralMylan Institutional1999-12-15Not applicableUs
RifampinInjection, powder, lyophilized, for solution600 mg/1IntravenousWest Ward Pharmaceutical2016-03-03Not applicableUs
RifampinInjection, powder, lyophilized, for solution600 mg/10mLIntravenousAkorn2017-04-282017-06-20Us
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
IsonaRifRifampicin (300 mg/1) + Isoniazid (150 mg/1)CapsuleOralVersa Pharm Incorporated2005-09-01Not applicableUs
RifamateRifampicin (300 mg/1) + Isoniazid (150 mg/1)CapsuleOralSanofi Aventis1975-07-11Not applicableUs
RifaterRifampicin (120 mg/1) + Isoniazid (50 mg/1) + Pyrazinamide (300 mg/1)Tablet, sugar coatedOralRemedy Repack2010-09-152016-10-13Us
RifaterRifampicin (120 mg) + Isoniazid (50 mg) + Pyrazinamide (300 mg)TabletOralSanofi Aventis1995-12-312017-03-29Canada
RifaterRifampicin (120 mg/1) + Isoniazid (50 mg/1) + Pyrazinamide (300 mg/1)Tablet, sugar coatedOralSanofi Aventis1994-05-31Not applicableUs
International/Other Brands
Rifadine / Rifaldin / Rifoldin / Rimactan / Rimactane / Rofact / Tubocin
Categories
UNII
VJT6J7R4TR
CAS number
13292-46-1
Weight
Average: 822.9402
Monoisotopic: 822.40512334
Chemical Formula
C43H58N4O12
InChI Key
JQXXHWHPUNPDRT-WLSIYKJHSA-N
InChI
InChI=1S/C43H58N4O12/c1-21-12-11-13-22(2)42(55)45-33-28(20-44-47-17-15-46(9)16-18-47)37(52)30-31(38(33)53)36(51)26(6)40-32(30)41(54)43(8,59-40)57-19-14-29(56-10)23(3)39(58-27(7)48)25(5)35(50)24(4)34(21)49/h11-14,19-21,23-25,29,34-35,39,49-53H,15-18H2,1-10H3,(H,45,55)/b12-11+,19-14+,22-13-,44-20+/t21-,23+,24+,25+,29-,34-,35+,39+,43-/m0/s1
IUPAC Name
(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[(1E)-[(4-methylpiperazin-1-yl)imino]methyl]-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.1⁴,⁷.0⁵,²⁸]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl acetate
SMILES
CO[C@H]1\C=C\O[C@@]2(C)OC3=C(C2=O)C2=C(O)C(\C=N\N4CCN(C)CC4)=C(NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)C(O)=C2C(O)=C3C

Pharmacology

Indication

For the treatment of Tuberculosis and Tuberculosis-related mycobacterial infections.

Associated Conditions
Pharmacodynamics

Rifampin is an antibiotic that inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme. It is bactericidal and has a very broad spectrum of activity against most gram-positive and gram-negative organisms (including Pseudomonas aeruginosa) and specifically Mycobacterium tuberculosis. Because of rapid emergence of resistant bacteria, use is restricted to treatment of mycobacterial infections and a few other indications. Rifampin is well absorbed when taken orally and is distributed widely in body tissues and fluids, including the CSF. It is metabolized in the liver and eliminated in bile and, to a much lesser extent, in urine, but dose adjustments are unnecessary with renal insufficiency.

Mechanism of action

Rifampin acts via the inhibition of DNA-dependent RNA polymerase, leading to a suppression of RNA synthesis and cell death.

TargetActionsOrganism
ADNA-directed RNA polymerase subunit beta
inhibitor
Escherichia coli (strain K12)
ADNA-directed RNA polymerase subunit beta'
inhibitor
Escherichia coli (strain K12)
UNuclear receptor subfamily 1 group I member 2
agonist
Human
USolute carrier organic anion transporter family member 1B1Not AvailableHuman
USolute carrier organic anion transporter family member 1A2Not AvailableHuman
USolute carrier organic anion transporter family member 1B3Not AvailableHuman
ULanosterol 14-alpha demethylaseNot AvailableHuman
USerum albuminNot AvailableHuman
USolute carrier organic anion transporter family member 2B1Not AvailableHuman
Absorption

Well absorbed from gastrointestinal tract.

Volume of distribution
Not Available
Protein binding

89%

Metabolism

Primarily hepatic, rapidly deacetylated.

Route of elimination

Less than 30% of the dose is excreted in the urine as rifampin or metabolites.

Half life

3.35 (+/- 0.66) hours

Clearance
  • 0.19 +/- 0.06 L/hr/kg [300 mg IV]
  • 0.14 +/- 0.03 L/hr/kg [600 mg IV]
Toxicity

LD50=1570 mg/kg (rat), chronic exposure may cause nausea and vomiting and unconsciousness

Affected organisms
  • Mycobacteria
  • Mycobacterium tuberculosis
  • Various gram-negative and gram-positive eubacteria
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
(R)-warfarinThe metabolism of (R)-warfarin can be increased when combined with Rifampicin.Experimental
(S)-WarfarinThe metabolism of (S)-Warfarin can be increased when combined with Rifampicin.Experimental, Investigational
16-BromoepiandrosteroneThe metabolism of 16-Bromoepiandrosterone can be increased when combined with Rifampicin.Investigational
3-isobutyl-1-methyl-7H-xanthineThe metabolism of 3-isobutyl-1-methyl-7H-xanthine can be increased when combined with Rifampicin.Experimental
3,5-diiodothyropropionic acidThe metabolism of 3,5-diiodothyropropionic acid can be increased when combined with Rifampicin.Investigational
4-hydroxycoumarinThe metabolism of 4-hydroxycoumarin can be increased when combined with Rifampicin.Experimental
5-androstenedioneThe metabolism of 5-androstenedione can be increased when combined with Rifampicin.Experimental, Illicit
6-O-benzylguanineThe metabolism of 6-O-benzylguanine can be increased when combined with Rifampicin.Investigational
8-chlorotheophyllineThe metabolism of 8-chlorotheophylline can be increased when combined with Rifampicin.Approved
AbacavirThe serum concentration of Abacavir can be decreased when it is combined with Rifampicin.Approved, Investigational
AbemaciclibThe serum concentration of Abemaciclib can be decreased when it is combined with Rifampicin.Approved, Investigational
AbirateroneThe serum concentration of Abiraterone can be decreased when it is combined with Rifampicin.Approved
AcebutololThe serum concentration of Acebutolol can be increased when it is combined with Rifampicin.Approved, Investigational
AcenocoumarolThe metabolism of Acenocoumarol can be increased when combined with Rifampicin.Approved, Investigational
AcetaminophenThe serum concentration of Acetaminophen can be decreased when it is combined with Rifampicin.Approved
AcetohexamideThe serum concentration of Acetohexamide can be decreased when it is combined with Rifampicin.Approved, Investigational, Withdrawn
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Rifampicin.Approved, Vet Approved
AdinazolamThe metabolism of Adinazolam can be increased when combined with Rifampicin.Approved
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Rifampicin.Approved
AgmatineThe metabolism of Agmatine can be increased when combined with Rifampicin.Experimental, Investigational
AlbendazoleThe metabolism of Albendazole can be increased when combined with Rifampicin.Approved, Vet Approved
AlclometasoneThe metabolism of Alclometasone can be increased when combined with Rifampicin.Approved
AldosteroneThe metabolism of Aldosterone can be increased when combined with Rifampicin.Experimental, Investigational
AlectinibThe serum concentration of Rifampicin can be increased when it is combined with Alectinib.Approved, Investigational
AlfentanilThe metabolism of Alfentanil can be increased when combined with Rifampicin.Approved, Illicit
AlfuzosinThe metabolism of Alfuzosin can be increased when combined with Rifampicin.Approved, Investigational
AliskirenThe metabolism of Aliskiren can be increased when combined with Rifampicin.Approved, Investigational
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Rifampicin.Approved, Investigational
AllylestrenolThe metabolism of Allylestrenol can be increased when combined with Rifampicin.Approved
AlmasilateAlmasilate can cause a decrease in the absorption of Rifampicin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Experimental
AlmotriptanThe metabolism of Almotriptan can be increased when combined with Rifampicin.Approved, Investigational
AlogliptinThe metabolism of Alogliptin can be increased when combined with Rifampicin.Approved
AloglutamolAloglutamol can cause a decrease in the absorption of Rifampicin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
AlosetronThe metabolism of Alosetron can be increased when combined with Rifampicin.Approved, Withdrawn
alpha-Tocopherol acetateThe metabolism of alpha-Tocopherol acetate can be increased when combined with Rifampicin.Approved
AlprazolamThe serum concentration of Alprazolam can be decreased when it is combined with Rifampicin.Approved, Illicit, Investigational
AluminiumAluminium can cause a decrease in the absorption of Rifampicin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
Aluminium acetoacetateAluminium acetoacetate can cause a decrease in the absorption of Rifampicin resulting in a reduced serum concentration and potentially a decrease in efficacy.Experimental
Aluminium glycinateAluminium glycinate can cause a decrease in the absorption of Rifampicin resulting in a reduced serum concentration and potentially a decrease in efficacy.Experimental
Aluminium phosphateAluminium phosphate can cause a decrease in the absorption of Rifampicin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
Aluminum hydroxideAluminum hydroxide can cause a decrease in the absorption of Rifampicin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
AlvocidibThe serum concentration of Alvocidib can be decreased when it is combined with Rifampicin.Experimental, Investigational
AmbrisentanThe metabolism of Ambrisentan can be increased when combined with Rifampicin.Approved, Investigational
AmbroxolThe metabolism of Ambroxol can be increased when combined with Rifampicin.Approved, Investigational
AmcinonideThe metabolism of Amcinonide can be increased when combined with Rifampicin.Approved
AminophenazoneThe metabolism of Aminophenazone can be increased when combined with Rifampicin.Approved, Withdrawn
AminophyllineThe metabolism of Aminophylline can be increased when combined with Rifampicin.Approved
AmiodaroneThe serum concentration of Amiodarone can be decreased when it is combined with Rifampicin.Approved, Investigational
AmitriptylineThe serum concentration of Amitriptyline can be decreased when it is combined with Rifampicin.Approved
AmlodipineThe metabolism of Amlodipine can be increased when combined with Rifampicin.Approved
AmodiaquineThe metabolism of Amodiaquine can be increased when combined with Rifampicin.Approved, Investigational
AmoxapineThe metabolism of Amoxapine can be increased when combined with Rifampicin.Approved
AmprenavirThe serum concentration of Amprenavir can be decreased when it is combined with Rifampicin.Approved, Investigational
AmsacrineThe serum concentration of Rifampicin can be increased when it is combined with Amsacrine.Approved, Investigational
AnagrelideThe metabolism of Anagrelide can be increased when combined with Rifampicin.Approved
AndrostenedioneThe metabolism of Androstenedione can be increased when combined with Rifampicin.Experimental, Illicit
AnnamycinThe serum concentration of Rifampicin can be increased when it is combined with Annamycin.Investigational
AntipyrineThe metabolism of Antipyrine can be increased when combined with Rifampicin.Approved, Investigational
ApalutamideThe serum concentration of Rifampicin can be decreased when it is combined with Apalutamide.Approved, Investigational
ApixabanThe serum concentration of Apixaban can be decreased when it is combined with Rifampicin.Approved
ApremilastThe serum concentration of Apremilast can be decreased when it is combined with Rifampicin.Approved, Investigational
AprepitantThe serum concentration of Aprepitant can be decreased when it is combined with Rifampicin.Approved, Investigational
AranidipineThe metabolism of Aranidipine can be increased when combined with Rifampicin.Approved, Investigational
ArgatrobanThe metabolism of Argatroban can be increased when combined with Rifampicin.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be decreased when it is combined with Rifampicin.Approved, Investigational
Aripiprazole lauroxilThe serum concentration of aripiprazole, an active metabolite of Rifampicin, can be decreased when used in combination with Aripiprazole lauroxil.Approved, Investigational
Arsenic trioxideThe serum concentration of Arsenic trioxide can be increased when it is combined with Rifampicin.Approved, Investigational
ArtemetherThe serum concentration of the active metabolites of Artemether can be reduced when Artemether is used in combination with Rifampicin resulting in a loss in efficacy.Approved
Ascorbic acidThe serum concentration of Ascorbic acid can be increased when it is combined with Rifampicin.Approved, Nutraceutical
AsenapineThe metabolism of Asenapine can be increased when combined with Rifampicin.Approved
AstemizoleThe metabolism of Astemizole can be increased when combined with Rifampicin.Approved, Withdrawn
AsunaprevirThe serum concentration of Asunaprevir can be decreased when it is combined with Rifampicin.Approved, Investigational, Withdrawn
AtazanavirThe serum concentration of Atazanavir can be decreased when it is combined with Rifampicin.Approved, Investigational
AtorvastatinThe serum concentration of Atorvastatin can be decreased when it is combined with Rifampicin.Approved
AtovaquoneThe metabolism of Atovaquone can be increased when combined with Rifampicin.Approved
AtrasentanThe excretion of Atrasentan can be decreased when combined with Rifampicin.Investigational
AvanafilThe metabolism of Avanafil can be increased when combined with Rifampicin.Approved
AvatrombopagThe serum concentration of Avatrombopag can be increased when it is combined with Rifampicin.Approved, Investigational
AxitinibThe serum concentration of Axitinib can be decreased when it is combined with Rifampicin.Approved, Investigational
AzathioprineThe metabolism of Azathioprine can be increased when combined with Rifampicin.Approved
AzelastineThe metabolism of Azelastine can be increased when combined with Rifampicin.Approved
AzelnidipineThe metabolism of Azelnidipine can be increased when combined with Rifampicin.Approved, Investigational
AzithromycinThe metabolism of Azithromycin can be increased when combined with Rifampicin.Approved
Bacillus calmette-guerin substrain connaught live antigenThe therapeutic efficacy of Bacillus calmette-guerin substrain connaught live antigen can be decreased when used in combination with Rifampicin.Approved, Investigational
Bacillus calmette-guerin substrain danish 1331 live antigenThe therapeutic efficacy of Bacillus calmette-guerin substrain danish 1331 live antigen can be decreased when used in combination with Rifampicin.Investigational
Bacillus calmette-guerin substrain tice live antigenThe therapeutic efficacy of Bacillus calmette-guerin substrain tice live antigen can be decreased when used in combination with Rifampicin.Approved
Bafilomycin A1The serum concentration of Rifampicin can be increased when it is combined with Bafilomycin A1.Experimental
Bafilomycin B1The serum concentration of Rifampicin can be increased when it is combined with Bafilomycin B1.Experimental
BalaglitazoneThe metabolism of Balaglitazone can be increased when combined with Rifampicin.Investigational
BanoxantroneThe metabolism of Banoxantrone can be increased when combined with Rifampicin.Investigational
BarbitalThe metabolism of Barbital can be increased when combined with Rifampicin.Illicit
BaricitinibThe metabolism of Baricitinib can be increased when combined with Rifampicin.Approved, Investigational
BarnidipineThe serum concentration of Barnidipine can be decreased when it is combined with Rifampicin.Approved
BazedoxifeneThe serum concentration of Bazedoxifene can be decreased when it is combined with Rifampicin.Approved, Investigational
BCG vaccineThe therapeutic efficacy of BCG vaccine can be decreased when used in combination with Rifampicin.Investigational
Beclomethasone dipropionateThe metabolism of Beclomethasone dipropionate can be increased when combined with Rifampicin.Approved, Investigational
BedaquilineThe serum concentration of Bedaquiline can be decreased when it is combined with Rifampicin.Approved
BelinostatThe serum concentration of Belinostat can be decreased when it is combined with Rifampicin.Approved, Investigational
BencyclaneThe metabolism of Bencyclane can be increased when combined with Rifampicin.Experimental
BendamustineThe serum concentration of Bendamustine can be decreased when it is combined with Rifampicin.Approved, Investigational
BenidipineThe metabolism of Benidipine can be increased when combined with Rifampicin.Approved, Investigational
BenzphetamineThe metabolism of Benzphetamine can be increased when combined with Rifampicin.Approved, Illicit
BenzquinamideThe serum concentration of Rifampicin can be increased when it is combined with Benzquinamide.Withdrawn
BenzydamineThe metabolism of Benzydamine can be increased when combined with Rifampicin.Approved
Benzyl alcoholThe metabolism of Benzyl alcohol can be increased when combined with Rifampicin.Approved
BenzylpenicillinThe excretion of Benzylpenicillin can be decreased when combined with Rifampicin.Approved, Vet Approved
BepridilThe metabolism of Bepridil can be increased when combined with Rifampicin.Approved, Withdrawn
BetamethasoneThe metabolism of Betamethasone can be increased when combined with Rifampicin.Approved, Vet Approved
BetaxololThe metabolism of Betaxolol can be increased when combined with Rifampicin.Approved, Investigational
BexaroteneThe metabolism of Bexarotene can be increased when combined with Rifampicin.Approved, Investigational
BezafibrateThe metabolism of Bezafibrate can be increased when combined with Rifampicin.Approved, Investigational
BicalutamideThe metabolism of Bicalutamide can be increased when combined with Rifampicin.Approved
BictegravirThe serum concentration of Bictegravir can be decreased when it is combined with Rifampicin.Approved, Investigational
BinimetinibThe serum concentration of Binimetinib can be decreased when it is combined with Rifampicin.Approved, Investigational
BioallethrinThe metabolism of Bioallethrin can be increased when combined with Rifampicin.Approved, Experimental
Biricodar dicitrateThe serum concentration of Rifampicin can be increased when it is combined with Biricodar dicitrate.Investigational
Bismuth subnitrateBismuth subnitrate can cause a decrease in the absorption of Rifampicin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
BisoprololThe metabolism of Bisoprolol can be increased when combined with Rifampicin.Approved
BlonanserinThe metabolism of Blonanserin can be increased when combined with Rifampicin.Approved, Investigational
BortezomibThe serum concentration of Bortezomib can be decreased when it is combined with Rifampicin.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Rifampicin.Approved
Brefeldin AThe serum concentration of Rifampicin can be increased when it is combined with Brefeldin A.Experimental
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Rifampicin.Approved, Investigational
BrexpiprazoleThe serum concentration of Brexpiprazole can be decreased when it is combined with Rifampicin.Approved, Investigational
BrigatinibThe serum concentration of Brigatinib can be decreased when it is combined with Rifampicin.Approved, Investigational
BrinzolamideThe metabolism of Brinzolamide can be increased when combined with Rifampicin.Approved
BrivaracetamThe metabolism of Brivaracetam can be increased when combined with Rifampicin.Approved, Investigational
BromazepamThe metabolism of Bromazepam can be increased when combined with Rifampicin.Approved, Illicit, Investigational
BromocriptineThe metabolism of Bromocriptine can be increased when combined with Rifampicin.Approved, Investigational
BromperidolThe serum concentration of Bromperidol can be increased when it is combined with Rifampicin.Approved, Investigational
BrompheniramineThe metabolism of Brompheniramine can be increased when combined with Rifampicin.Approved
BudesonideThe metabolism of Budesonide can be increased when combined with Rifampicin.Approved
BufuralolThe metabolism of Bufuralol can be increased when combined with Rifampicin.Experimental, Investigational
BupivacaineThe metabolism of Bupivacaine can be increased when combined with Rifampicin.Approved, Investigational
BuprenorphineThe serum concentration of Buprenorphine can be decreased when it is combined with Rifampicin.Approved, Illicit, Investigational, Vet Approved
BupropionThe metabolism of Bupropion can be increased when combined with Rifampicin.Approved
BuspironeThe metabolism of Buspirone can be increased when combined with Rifampicin.Approved, Investigational
BusulfanThe metabolism of Busulfan can be increased when combined with Rifampicin.Approved, Investigational
CabazitaxelThe metabolism of Cabazitaxel can be increased when combined with Rifampicin.Approved
CabergolineThe metabolism of Cabergoline can be increased when combined with Rifampicin.Approved
CabozantinibThe serum concentration of Cabozantinib can be decreased when it is combined with Rifampicin.Approved, Investigational
CaffeineThe metabolism of Caffeine can be increased when combined with Rifampicin.Approved
CalcitriolThe metabolism of Calcitriol can be increased when combined with Rifampicin.Approved, Nutraceutical
Calcium CarbonateCalcium Carbonate can cause a decrease in the absorption of Rifampicin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
Calcium silicateCalcium silicate can cause a decrease in the absorption of Rifampicin resulting in a reduced serum concentration and potentially a decrease in efficacy.Experimental
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Rifampicin.Experimental
CanagliflozinThe serum concentration of Canagliflozin can be decreased when it is combined with Rifampicin.Approved
CannabidiolThe serum concentration of Cannabidiol can be decreased when it is combined with Rifampicin.Approved, Investigational
CaptoprilThe serum concentration of Rifampicin can be increased when it is combined with Captopril.Approved
CarbamazepineThe metabolism of Carbamazepine can be increased when combined with Rifampicin.Approved, Investigational
CarbinoxamineThe metabolism of Carbinoxamine can be increased when combined with Rifampicin.Approved
CarboxyamidotriazoleThe metabolism of Carboxyamidotriazole can be increased when combined with Rifampicin.Investigational
CarbutamideThe serum concentration of Carbutamide can be decreased when it is combined with Rifampicin.Experimental
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Rifampicin.Approved, Investigational
CariprazineThe metabolism of Cariprazine can be increased when combined with Rifampicin.Approved, Investigational
CarisoprodolThe metabolism of Carisoprodol can be increased when combined with Rifampicin.Approved
CaroverineThe metabolism of Caroverine can be increased when combined with Rifampicin.Experimental
CarvedilolThe serum concentration of Carvedilol can be decreased when it is combined with Rifampicin.Approved, Investigational
CaspofunginThe serum concentration of Caspofungin can be decreased when it is combined with Rifampicin.Approved
CefoperazoneThe serum concentration of Rifampicin can be increased when it is combined with Cefoperazone.Approved, Investigational
CeftriaxoneThe serum concentration of Rifampicin can be increased when it is combined with Ceftriaxone.Approved
CelecoxibThe metabolism of Celecoxib can be increased when combined with Rifampicin.Approved, Investigational
CeliprololThe metabolism of Celiprolol can be increased when combined with Rifampicin.Approved, Investigational
CephalexinThe metabolism of Cephalexin can be increased when combined with Rifampicin.Approved, Investigational, Vet Approved
CeritinibThe serum concentration of Ceritinib can be decreased when it is combined with Rifampicin.Approved
CerivastatinThe serum concentration of Cerivastatin can be decreased when it is combined with Rifampicin.Approved, Withdrawn
Cerliponase alfaThe serum concentration of Cerliponase alfa can be increased when it is combined with Rifampicin.Approved, Investigational
CevimelineThe metabolism of Cevimeline can be increased when combined with Rifampicin.Approved
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be increased when combined with Rifampicin.Approved
ChlorambucilThe serum concentration of Chlorambucil can be increased when it is combined with Rifampicin.Approved
ChloramphenicolThe metabolism of Chloramphenicol can be increased when combined with Rifampicin.Approved, Vet Approved
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be increased when combined with Rifampicin.Approved, Illicit, Investigational
ChlormadinoneThe metabolism of Chlormadinone can be increased when combined with Rifampicin.Experimental
ChloroformThe serum concentration of Rifampicin can be increased when it is combined with Chloroform.Vet Approved
ChloroquineThe metabolism of Chloroquine can be increased when combined with Rifampicin.Approved, Investigational, Vet Approved
ChlorphenamineThe metabolism of Chlorphenamine can be increased when combined with Rifampicin.Approved
ChlorpromazineThe metabolism of Chlorpromazine can be increased when combined with Rifampicin.Approved, Investigational, Vet Approved
ChlorpropamideThe serum concentration of Chlorpropamide can be decreased when it is combined with Rifampicin.Approved, Investigational
ChlorprothixeneThe serum concentration of Rifampicin can be increased when it is combined with Chlorprothixene.Approved, Investigational, Withdrawn
ChlorzoxazoneThe metabolism of Chlorzoxazone can be increased when combined with Rifampicin.Approved
CholecalciferolThe metabolism of Cholecalciferol can be increased when combined with Rifampicin.Approved, Nutraceutical
CholecystokininThe excretion of Cholecystokinin can be decreased when combined with Rifampicin.Approved, Investigational
Cholic AcidThe risk or severity of liver damage can be increased when Cholic Acid is combined with Rifampicin.Approved
CiclesonideThe metabolism of Ciclesonide can be increased when combined with Rifampicin.Approved, Investigational
CiglitazoneThe metabolism of Ciglitazone can be increased when combined with Rifampicin.Experimental
CilnidipineThe metabolism of Cilnidipine can be increased when combined with Rifampicin.Approved, Investigational
CilostazolThe metabolism of Cilostazol can be increased when combined with Rifampicin.Approved, Investigational
CimetidineThe serum concentration of Cimetidine can be increased when it is combined with Rifampicin.Approved, Investigational
CinacalcetThe metabolism of Cinacalcet can be increased when combined with Rifampicin.Approved
CinnarizineThe metabolism of Cinnarizine can be increased when combined with Rifampicin.Approved, Investigational
CiprofloxacinThe serum concentration of Ciprofloxacin can be increased when it is combined with Rifampicin.Approved, Investigational
CisaprideThe metabolism of Cisapride can be increased when combined with Rifampicin.Approved, Investigational, Withdrawn
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Rifampicin.Approved
CitalopramThe serum concentration of Citalopram can be decreased when it is combined with Rifampicin.Approved
ClarithromycinThe serum concentration of the active metabolites of Clarithromycin can be increased when Clarithromycin is used in combination with Rifampicin.Approved
ClevidipineThe metabolism of Clevidipine can be increased when combined with Rifampicin.Approved, Investigational
ClindamycinThe metabolism of Clindamycin can be increased when combined with Rifampicin.Approved, Vet Approved
ClobazamThe metabolism of Clobazam can be increased when combined with Rifampicin.Approved, Illicit
ClobetasolThe metabolism of Clobetasol can be increased when combined with Rifampicin.Approved, Investigational
Clobetasol propionateThe metabolism of Clobetasol propionate can be increased when combined with Rifampicin.Approved
ClobetasoneThe metabolism of Clobetasone can be increased when combined with Rifampicin.Approved
ClofazimineThe risk or severity of liver damage can be increased when Rifampicin is combined with Clofazimine.Approved, Investigational
ClofibrateThe metabolism of Clofibrate can be increased when combined with Rifampicin.Approved, Investigational
clomethiazoleThe metabolism of clomethiazole can be increased when combined with Rifampicin.Investigational
ClomipramineThe metabolism of Clomipramine can be increased when combined with Rifampicin.Approved, Investigational, Vet Approved
ClonazepamThe metabolism of Clonazepam can be increased when combined with Rifampicin.Approved, Illicit
ClonidineThe metabolism of Clonidine can be increased when combined with Rifampicin.Approved
ClopidogrelThe therapeutic efficacy of Clopidogrel can be increased when used in combination with Rifampicin.Approved
ClorazepateThe metabolism of Clorazepate can be increased when combined with Rifampicin.Approved, Illicit
ClorindioneThe metabolism of Clorindione can be increased when combined with Rifampicin.Experimental
ClotiazepamThe metabolism of Clotiazepam can be increased when combined with Rifampicin.Approved, Illicit
ClotrimazoleThe risk or severity of liver damage can be increased when Rifampicin is combined with Clotrimazole.Approved, Vet Approved
ClozapineThe serum concentration of Clozapine can be decreased when it is combined with Rifampicin.Approved
CobicistatThe serum concentration of Cobicistat can be decreased when it is combined with Rifampicin.Approved
CobimetinibThe serum concentration of Cobimetinib can be decreased when it is combined with Rifampicin.Approved, Investigational
CocaineThe metabolism of Cocaine can be increased when combined with Rifampicin.Approved, Illicit
CodeineThe serum concentration of Codeine can be decreased when it is combined with Rifampicin.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Rifampicin.Approved
Concanamycin AThe serum concentration of Rifampicin can be increased when it is combined with Concanamycin A.Experimental
ConivaptanThe serum concentration of Conivaptan can be increased when it is combined with Rifampicin.Approved, Investigational
Conjugated estrogensThe metabolism of Conjugated estrogens can be increased when combined with Rifampicin.Approved
CopanlisibThe metabolism of Copanlisib can be increased when combined with Rifampicin.Approved, Investigational
CorticosteroneThe metabolism of Corticosterone can be increased when combined with Rifampicin.Experimental
CorticotropinThe metabolism of Corticotropin can be increased when combined with Rifampicin.Approved, Investigational, Vet Approved
Cortisone acetateThe metabolism of Cortisone acetate can be increased when combined with Rifampicin.Approved, Investigational
CrizotinibThe serum concentration of Crizotinib can be decreased when it is combined with Rifampicin.Approved
CurcuminThe metabolism of Rifampicin can be decreased when combined with Curcumin.Approved, Investigational
CyclandelateThe metabolism of Cyclandelate can be increased when combined with Rifampicin.Approved
CyclobenzaprineThe serum concentration of Cyclobenzaprine can be decreased when it is combined with Rifampicin.Approved
CyclophosphamideThe metabolism of Cyclophosphamide can be increased when combined with Rifampicin.Approved, Investigational
CyclosporineThe risk or severity of liver damage can be increased when Rifampicin is combined with Cyclosporine.Approved, Investigational, Vet Approved
Cyproterone acetateThe metabolism of Cyproterone acetate can be increased when combined with Rifampicin.Approved, Investigational
CytarabineThe metabolism of Cytarabine can be increased when combined with Rifampicin.Approved, Investigational
Dabigatran etexilateThe serum concentration of Dabigatran etexilate can be decreased when it is combined with Rifampicin.Approved
DabrafenibThe serum concentration of Rifampicin can be decreased when it is combined with Dabrafenib.Approved, Investigational
DacarbazineThe metabolism of Dacarbazine can be increased when combined with Rifampicin.Approved, Investigational
DaclatasvirThe serum concentration of Daclatasvir can be decreased when it is combined with Rifampicin.Approved, Investigational
DactinomycinThe serum concentration of Dactinomycin can be increased when it is combined with Rifampicin.Approved, Investigational
DanazolThe metabolism of Rifampicin can be decreased when combined with Danazol.Approved
DantroleneThe metabolism of Dantrolene can be increased when combined with Rifampicin.Approved, Investigational
DapagliflozinThe metabolism of Dapagliflozin can be increased when combined with Rifampicin.Approved
DapsoneThe metabolism of Dapsone can be increased when combined with Rifampicin.Approved, Investigational
DarifenacinThe metabolism of Darifenacin can be increased when combined with Rifampicin.Approved, Investigational
DarodipineThe metabolism of Darodipine can be increased when combined with Rifampicin.Experimental
DarunavirThe serum concentration of Darunavir can be decreased when it is combined with Rifampicin.Approved
DasabuvirThe serum concentration of Dasabuvir can be decreased when it is combined with Rifampicin.Approved
DasatinibThe serum concentration of Dasatinib can be decreased when it is combined with Rifampicin.Approved, Investigational
DaunorubicinRifampicin may decrease the excretion rate of Daunorubicin which could result in a higher serum level.Approved
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Rifampicin.Approved, Investigational
DeferasiroxThe serum concentration of Deferasirox can be decreased when it is combined with Rifampicin.Approved, Investigational
DeflazacortThe metabolism of Deflazacort can be increased when combined with Rifampicin.Approved, Investigational
DelafloxacinThe serum concentration of Delafloxacin can be decreased when it is combined with Rifampicin.Approved, Investigational
DelamanidThe metabolism of Delamanid can be increased when combined with Rifampicin.Approved, Investigational
DelavirdineThe metabolism of Delavirdine can be increased when combined with Rifampicin.Approved
DemegestoneThe metabolism of Demegestone can be increased when combined with Rifampicin.Approved
DesipramineThe metabolism of Desipramine can be increased when combined with Rifampicin.Approved, Investigational
DesmethylsertralineThe serum concentration of Rifampicin can be increased when it is combined with Desmethylsertraline.Experimental
DesogestrelThe metabolism of Desogestrel can be increased when combined with Rifampicin.Approved
DesonideThe metabolism of Desonide can be increased when combined with Rifampicin.Approved, Investigational
Desoxycorticosterone acetateThe metabolism of Desoxycorticosterone acetate can be increased when combined with Rifampicin.Approved
Desoxycorticosterone PivalateThe metabolism of Desoxycorticosterone Pivalate can be increased when combined with Rifampicin.Experimental, Vet Approved
DesvenlafaxineThe metabolism of Desvenlafaxine can be increased when combined with Rifampicin.Approved, Investigational
DeutetrabenazineThe metabolism of Deutetrabenazine can be increased when combined with Rifampicin.Approved, Investigational
DexamethasoneThe serum concentration of Dexamethasone can be decreased when it is combined with Rifampicin.Approved, Investigational, Vet Approved
Dexamethasone isonicotinateThe metabolism of Dexamethasone isonicotinate can be increased when combined with Rifampicin.Vet Approved
Dexchlorpheniramine maleateThe metabolism of Dexchlorpheniramine maleate can be increased when combined with Rifampicin.Approved
DexfenfluramineThe metabolism of Dexfenfluramine can be increased when combined with Rifampicin.Approved, Illicit, Investigational, Withdrawn
DexlansoprazoleDexlansoprazole can cause a decrease in the absorption of Rifampicin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
DexniguldipineThe metabolism of Dexniguldipine can be increased when combined with Rifampicin.Experimental
DexrabeprazoleDexrabeprazole can cause a decrease in the absorption of Rifampicin resulting in a reduced serum concentration and potentially a decrease in efficacy.Experimental
DextromethorphanThe metabolism of Dextromethorphan can be increased when combined with Rifampicin.Approved
DextropropoxypheneThe metabolism of Dextropropoxyphene can be increased when combined with Rifampicin.Approved, Illicit, Investigational, Withdrawn
DexverapamilThe metabolism of Dexverapamil can be increased when combined with Rifampicin.Experimental
DiazepamThe metabolism of Diazepam can be increased when combined with Rifampicin.Approved, Illicit, Investigational, Vet Approved
DicoumarolThe metabolism of Dicoumarol can be increased when combined with Rifampicin.Approved
DienogestThe serum concentration of Dienogest can be decreased when it is combined with Rifampicin.Approved
Diethyl etherThe serum concentration of Rifampicin can be increased when it is combined with Diethyl ether.Experimental
DiethylstilbestrolThe metabolism of Diethylstilbestrol can be increased when combined with Rifampicin.Approved, Investigational
DifluocortoloneThe metabolism of Difluocortolone can be increased when combined with Rifampicin.Approved, Investigational, Withdrawn
DifluprednateThe metabolism of Difluprednate can be increased when combined with Rifampicin.Approved
DigitoxinThe metabolism of Digitoxin can be increased when combined with Rifampicin.Approved, Investigational
DigoxinRifampicin may decrease the excretion rate of Digoxin which could result in a higher serum level.Approved
DihydralazineThe metabolism of Dihydralazine can be increased when combined with Rifampicin.Approved, Investigational
Dihydro-alpha-ergocryptineThe metabolism of Dihydro-alpha-ergocryptine can be increased when combined with Rifampicin.Approved
DihydrocodeineThe metabolism of Dihydrocodeine can be increased when combined with Rifampicin.Approved, Illicit
DihydroergocornineThe metabolism of Dihydroergocornine can be increased when combined with Rifampicin.Approved
DihydroergocristineThe metabolism of Dihydroergocristine can be increased when combined with Rifampicin.Approved, Experimental
DihydroergocryptineThe metabolism of Dihydroergocryptine can be increased when combined with Rifampicin.Experimental
DihydroergotamineThe metabolism of Dihydroergotamine can be increased when combined with Rifampicin.Approved, Investigational
DiltiazemThe serum concentration of Diltiazem can be decreased when it is combined with Rifampicin.Approved, Investigational
DinoprostoneThe metabolism of Dinoprostone can be increased when combined with Rifampicin.Approved
DiphenadioneThe metabolism of Diphenadione can be increased when combined with Rifampicin.Experimental
DipyridamoleThe serum concentration of Rifampicin can be increased when it is combined with Dipyridamole.Approved
DisopyramideThe serum concentration of Disopyramide can be decreased when it is combined with Rifampicin.Approved
DisulfiramThe metabolism of Disulfiram can be increased when combined with Rifampicin.Approved
DocetaxelThe metabolism of Docetaxel can be increased when combined with Rifampicin.Approved, Investigational
DofequidarThe serum concentration of Rifampicin can be increased when it is combined with Dofequidar.Experimental, Investigational
DofetilideThe metabolism of Dofetilide can be increased when combined with Rifampicin.Approved, Investigational
DolasetronThe metabolism of Dolasetron can be increased when combined with Rifampicin.Approved, Investigational
DomperidoneThe metabolism of Domperidone can be increased when combined with Rifampicin.Approved, Investigational, Vet Approved
DonepezilThe metabolism of Donepezil can be increased when combined with Rifampicin.Approved
DorzolamideThe metabolism of Dorzolamide can be increased when combined with Rifampicin.Approved
DosulepinThe metabolism of Dosulepin can be increased when combined with Rifampicin.Approved
DotarizineThe metabolism of Dotarizine can be increased when combined with Rifampicin.Investigational
DovitinibThe serum concentration of Rifampicin can be increased when it is combined with Dovitinib.Investigational
DoxazosinThe serum concentration of Rifampicin can be increased when it is combined with Doxazosin.Approved
DoxepinThe metabolism of Doxepin can be increased when combined with Rifampicin.Approved, Investigational
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Rifampicin.Approved, Investigational
DoxycyclineThe serum concentration of Doxycycline can be decreased when it is combined with Rifampicin.Approved, Investigational, Vet Approved
DronabinolThe serum concentration of Dronabinol can be decreased when it is combined with Rifampicin.Approved, Illicit
DronedaroneThe serum concentration of Dronedarone can be decreased when it is combined with Rifampicin.Approved
DrospirenoneThe metabolism of Drospirenone can be increased when combined with Rifampicin.Approved
DuloxetineThe metabolism of Duloxetine can be increased when combined with Rifampicin.Approved
DutasterideThe metabolism of Dutasteride can be increased when combined with Rifampicin.Approved, Investigational
DydrogesteroneThe metabolism of Dydrogesterone can be increased when combined with Rifampicin.Approved, Investigational, Withdrawn
EconazoleThe serum concentration of Rifampicin can be increased when it is combined with Econazole.Approved
EdoxabanThe serum concentration of Edoxaban can be decreased when it is combined with Rifampicin.Approved
EfavirenzThe serum concentration of Efavirenz can be decreased when it is combined with Rifampicin.Approved, Investigational
EfonidipineThe metabolism of Efonidipine can be increased when combined with Rifampicin.Approved, Investigational
ElacridarThe serum concentration of Rifampicin can be increased when it is combined with Elacridar.Investigational
ElagolixThe serum concentration of Elagolix can be decreased when it is combined with Rifampicin.Approved, Investigational
ElbasvirThe metabolism of Elbasvir can be increased when combined with Rifampicin.Approved
EletriptanThe metabolism of Eletriptan can be increased when combined with Rifampicin.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be decreased when it is combined with Rifampicin.Approved
EltrombopagThe serum concentration of Eltrombopag can be decreased when it is combined with Rifampicin.Approved
EluxadolineThe serum concentration of Eluxadoline can be increased when it is combined with Rifampicin.Approved, Investigational
EmopamilThe metabolism of Emopamil can be increased when combined with Rifampicin.Experimental
EnalaprilThe metabolism of Enalapril can be increased when combined with Rifampicin.Approved, Vet Approved
EnasidenibThe serum concentration of Enasidenib can be decreased when it is combined with Rifampicin.Approved, Investigational
EncorafenibThe metabolism of Encorafenib can be increased when combined with Rifampicin.Approved, Investigational
EnzalutamideThe serum concentration of Enzalutamide can be decreased when it is combined with Rifampicin.Approved
EperisoneThe metabolism of Eperisone can be increased when combined with Rifampicin.Approved, Investigational
EpinastineThe metabolism of Epinastine can be increased when combined with Rifampicin.Approved, Investigational
EplerenoneThe metabolism of Eplerenone can be increased when combined with Rifampicin.Approved
EquileninThe metabolism of Equilenin can be increased when combined with Rifampicin.Experimental
EquilinThe metabolism of Equilin can be increased when combined with Rifampicin.Approved
ErgocalciferolThe metabolism of Ergocalciferol can be increased when combined with Rifampicin.Approved, Nutraceutical
Ergoloid mesylateThe metabolism of Ergoloid mesylate can be increased when combined with Rifampicin.Approved
ErgonovineThe metabolism of Ergonovine can be increased when combined with Rifampicin.Approved
ErgotamineThe metabolism of Ergotamine can be increased when combined with Rifampicin.Approved
ErlotinibThe serum concentration of Erlotinib can be decreased when it is combined with Rifampicin.Approved, Investigational
ErtugliflozinThe serum concentration of Ertugliflozin can be decreased when it is combined with Rifampicin.Approved, Investigational
ErythromycinThe metabolism of Erythromycin can be increased when combined with Rifampicin.Approved, Investigational, Vet Approved
EscitalopramThe metabolism of Escitalopram can be increased when combined with Rifampicin.Approved, Investigational
EsomeprazoleThe serum concentration of Esomeprazole can be decreased when it is combined with Rifampicin.Approved, Investigational
EstazolamThe metabolism of Estazolam can be increased when combined with Rifampicin.Approved, Illicit
EstradiolThe serum concentration of Estradiol can be decreased when it is combined with Rifampicin.Approved, Investigational, Vet Approved
Estradiol acetateThe serum concentration of Estradiol acetate can be decreased when it is combined with Rifampicin.Approved, Investigational, Vet Approved
Estradiol benzoateThe serum concentration of Estradiol benzoate can be decreased when it is combined with Rifampicin.Approved, Investigational, Vet Approved
Estradiol cypionateThe serum concentration of Estradiol cypionate can be decreased when it is combined with Rifampicin.Approved, Investigational, Vet Approved
Estradiol dienanthateThe serum concentration of Estradiol dienanthate can be decreased when it is combined with Rifampicin.Approved, Investigational, Vet Approved
Estradiol valerateThe serum concentration of Estradiol valerate can be decreased when it is combined with Rifampicin.Approved, Investigational, Vet Approved
EstramustineThe metabolism of Estramustine can be increased when combined with Rifampicin.Approved, Investigational
EstriolThe serum concentration of Estriol can be increased when it is combined with Rifampicin.Approved, Investigational, Vet Approved
Estrogens, esterifiedThe metabolism of Estrogens, esterified can be increased when combined with Rifampicin.Approved
EstroneThe metabolism of Estrone can be increased when combined with Rifampicin.Approved
Estrone sulfateThe metabolism of Estrone sulfate can be increased when combined with Rifampicin.Approved
EszopicloneThe metabolism of Eszopiclone can be increased when combined with Rifampicin.Approved, Investigational
EthanolThe metabolism of Ethanol can be increased when combined with Rifampicin.Approved
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Rifampicin.Approved
EthosuximideThe metabolism of Ethosuximide can be increased when combined with Rifampicin.Approved
Ethyl biscoumacetateThe metabolism of Ethyl biscoumacetate can be increased when combined with Rifampicin.Withdrawn
EthylmorphineThe metabolism of Ethylmorphine can be increased when combined with Rifampicin.Approved, Illicit
EthynodiolThe metabolism of Ethynodiol can be increased when combined with Rifampicin.Experimental
Ethynodiol diacetateThe metabolism of Ethynodiol diacetate can be increased when combined with Rifampicin.Approved
EtizolamThe metabolism of Etizolam can be increased when combined with Rifampicin.Approved
EtonogestrelThe metabolism of Etonogestrel can be increased when combined with Rifampicin.Approved, Investigational
EtoricoxibThe metabolism of Etoricoxib can be increased when combined with Rifampicin.Approved, Investigational
EtravirineThe metabolism of Etravirine can be increased when combined with Rifampicin.Approved
EverolimusThe serum concentration of Everolimus can be decreased when it is combined with Rifampicin.Approved
ExemestaneThe serum concentration of Exemestane can be decreased when it is combined with Rifampicin.Approved, Investigational
EzetimibeThe serum concentration of Ezetimibe can be decreased when it is combined with Rifampicin.Approved
EzogabineThe serum concentration of Ezogabine can be decreased when it is combined with Rifampicin.Approved, Investigational
FamciclovirThe metabolism of Famciclovir can be increased when combined with Rifampicin.Approved, Investigational
FelbamateThe metabolism of Felbamate can be increased when combined with Rifampicin.Approved
FelodipineThe metabolism of Felodipine can be increased when combined with Rifampicin.Approved, Investigational
FendilineThe metabolism of Fendiline can be increased when combined with Rifampicin.Withdrawn
FenofibrateThe serum concentration of Fenofibrate can be decreased when it is combined with Rifampicin.Approved
FentanylThe serum concentration of Fentanyl can be decreased when it is combined with Rifampicin.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe metabolism of Fesoterodine can be increased when combined with Rifampicin.Approved
FexofenadineThe serum concentration of Fexofenadine can be decreased when it is combined with Rifampicin.Approved, Investigational
FidaxomicinThe serum concentration of Fidaxomicin can be increased when it is combined with Rifampicin.Approved
FimasartanThe serum concentration of Fimasartan can be increased when it is combined with Rifampicin.Approved, Investigational
FinasterideThe metabolism of Finasteride can be increased when combined with Rifampicin.Approved
FingolimodThe metabolism of Fingolimod can be increased when combined with Rifampicin.Approved, Investigational
Fish oilThe metabolism of Fish oil can be increased when combined with Rifampicin.Approved, Nutraceutical
FlibanserinThe serum concentration of Flibanserin can be decreased when it is combined with Rifampicin.Approved, Investigational
Fluciclovine (18F)The serum concentration of Fluciclovine (18F) can be increased when it is combined with Rifampicin.Approved
FluconazoleThe serum concentration of Rifampicin can be increased when it is combined with Fluconazole.Approved, Investigational
FludrocortisoneThe metabolism of Fludrocortisone can be increased when combined with Rifampicin.Approved, Investigational
FluindioneThe metabolism of Fluindione can be increased when combined with Rifampicin.Approved, Investigational
FlumethasoneThe metabolism of Flumethasone can be increased when combined with Rifampicin.Approved, Vet Approved
FlunarizineThe metabolism of Flunarizine can be increased when combined with Rifampicin.Approved
FlunisolideThe metabolism of Flunisolide can be increased when combined with Rifampicin.Approved, Investigational
FlunitrazepamThe metabolism of Flunitrazepam can be increased when combined with Rifampicin.Approved, Illicit
Fluocinolone AcetonideThe metabolism of Fluocinolone Acetonide can be increased when combined with Rifampicin.Approved, Investigational, Vet Approved
FluocinonideThe metabolism of Fluocinonide can be increased when combined with Rifampicin.Approved, Investigational
FluocortoloneThe metabolism of Fluocortolone can be increased when combined with Rifampicin.Approved, Withdrawn
FluoresceinRifampicin may decrease the excretion rate of Fluorescein which could result in a higher serum level.Approved
FluorometholoneThe metabolism of Fluorometholone can be increased when combined with Rifampicin.Approved, Investigational
FluorouracilThe metabolism of Fluorouracil can be increased when combined with Rifampicin.Approved
FluoxetineThe metabolism of Fluoxetine can be increased when combined with Rifampicin.Approved, Vet Approved
FlupentixolThe serum concentration of Flupentixol can be increased when it is combined with Rifampicin.Approved, Investigational, Withdrawn
FluphenazineThe serum concentration of Rifampicin can be increased when it is combined with Fluphenazine.Approved
FluprednideneThe metabolism of Fluprednidene can be increased when combined with Rifampicin.Approved, Withdrawn
FluprednisoloneThe metabolism of Fluprednisolone can be increased when combined with Rifampicin.Approved
FlurandrenolideThe metabolism of Flurandrenolide can be increased when combined with Rifampicin.Approved
FlurazepamThe metabolism of Flurazepam can be increased when combined with Rifampicin.Approved, Illicit, Investigational
FlurbiprofenThe serum concentration of Flurbiprofen can be decreased when it is combined with Rifampicin.Approved, Investigational
FluspirileneThe metabolism of Fluspirilene can be increased when combined with Rifampicin.Approved, Investigational
FlutamideThe metabolism of Flutamide can be increased when combined with Rifampicin.Approved, Investigational
FluticasoneThe metabolism of Fluticasone can be increased when combined with Rifampicin.Approved, Experimental, Investigational
Fluticasone furoateThe metabolism of Fluticasone furoate can be increased when combined with Rifampicin.Approved
Fluticasone propionateThe metabolism of Fluticasone propionate can be increased when combined with Rifampicin.Approved
FluvastatinThe serum concentration of Fluvastatin can be decreased when it is combined with Rifampicin.Approved
FluvoxamineThe metabolism of Fluvoxamine can be increased when combined with Rifampicin.Approved, Investigational
FosamprenavirThe serum concentration of Fosamprenavir can be decreased when it is combined with Rifampicin.Approved
FosaprepitantThe serum concentration of Fosaprepitant can be decreased when it is combined with Rifampicin.Approved
FosnetupitantThe metabolism of Fosnetupitant can be increased when combined with Rifampicin.Approved
FosphenytoinThe serum concentration of Fosphenytoin can be decreased when it is combined with Rifampicin.Approved, Investigational
FostamatinibThe metabolism of Fostamatinib can be increased when combined with Rifampicin.Approved, Investigational
FrovatriptanThe metabolism of Frovatriptan can be increased when combined with Rifampicin.Approved, Investigational
FulvestrantThe serum concentration of Fulvestrant can be decreased when it is combined with Rifampicin.Approved, Investigational
FurafyllineThe metabolism of Furafylline can be increased when combined with Rifampicin.Experimental
FurosemideThe serum concentration of Furosemide can be decreased when it is combined with Rifampicin.Approved, Vet Approved
Fusidic AcidThe serum concentration of Rifampicin can be increased when it is combined with Fusidic Acid.Approved, Investigational
GabapentinThe metabolism of Gabapentin can be increased when combined with Rifampicin.Approved, Investigational
Gadoxetic acidThe excretion of Gadoxetic acid can be decreased when combined with Rifampicin.Approved
GalantamineThe metabolism of Galantamine can be increased when combined with Rifampicin.Approved
GallopamilThe metabolism of Gallopamil can be increased when combined with Rifampicin.Investigational
GanciclovirThe metabolism of Ganciclovir can be increased when combined with Rifampicin.Approved, Investigational
GavestinelThe serum concentration of Gavestinel can be decreased when it is combined with Rifampicin.Investigational
GefitinibThe serum concentration of Gefitinib can be decreased when it is combined with Rifampicin.Approved, Investigational
GemfibrozilThe serum concentration of Gemfibrozil can be decreased when it is combined with Rifampicin.Approved
GenisteinThe metabolism of Genistein can be increased when combined with Rifampicin.Investigational
GestodeneThe metabolism of Gestodene can be increased when combined with Rifampicin.Approved, Investigational
GestrinoneThe metabolism of Gestrinone can be increased when combined with Rifampicin.Approved
GimatecanThe excretion of Gimatecan can be decreased when combined with Rifampicin.Investigational
GlecaprevirThe serum concentration of Glecaprevir can be increased when it is combined with Rifampicin.Approved, Investigational
GlibornurideThe serum concentration of Glibornuride can be decreased when it is combined with Rifampicin.Investigational, Withdrawn
GliclazideThe serum concentration of Gliclazide can be decreased when it is combined with Rifampicin.Approved
GlimepirideThe serum concentration of Glimepiride can be decreased when it is combined with Rifampicin.Approved
GliquidoneThe serum concentration of Gliquidone can be decreased when it is combined with Rifampicin.Approved, Investigational
GlisoxepideThe serum concentration of Glisoxepide can be decreased when it is combined with Rifampicin.Investigational
GlyburideThe serum concentration of Glyburide can be decreased when it is combined with Rifampicin.Approved
GlycerinThe serum concentration of Rifampicin can be increased when it is combined with Glycerin.Approved, Investigational
Glycochenodeoxycholic AcidRifampicin may decrease the excretion rate of Glycochenodeoxycholic Acid which could result in a higher serum level.Experimental
Gramicidin DThe serum concentration of Gramicidin D can be increased when it is combined with Rifampicin.Approved
GranisetronThe metabolism of Granisetron can be increased when combined with Rifampicin.Approved, Investigational
GrazoprevirThe metabolism of Grazoprevir can be increased when combined with Rifampicin.Approved
GrepafloxacinThe metabolism of Grepafloxacin can be increased when combined with Rifampicin.Approved, Investigational, Withdrawn
GuanabenzThe metabolism of Guanabenz can be increased when combined with Rifampicin.Approved, Investigational
GuanfacineThe serum concentration of Guanfacine can be decreased when it is combined with Rifampicin.Approved, Investigational
GuanineThe metabolism of Guanine can be increased when combined with Rifampicin.Experimental
HalcinonideThe metabolism of Halcinonide can be increased when combined with Rifampicin.Approved, Investigational, Withdrawn
HalofantrineThe metabolism of Halofantrine can be increased when combined with Rifampicin.Approved
HaloperidolThe metabolism of Haloperidol can be increased when combined with Rifampicin.Approved
HalothaneThe metabolism of Halothane can be increased when combined with Rifampicin.Approved, Vet Approved
HE3286The metabolism of HE3286 can be increased when combined with Rifampicin.Investigational
HexobarbitalThe metabolism of Hexobarbital can be increased when combined with Rifampicin.Approved
HistamineThe metabolism of Histamine can be increased when combined with Rifampicin.Approved, Investigational
HM-30181The serum concentration of Rifampicin can be increased when it is combined with HM-30181.Experimental
HycanthoneThe serum concentration of Rifampicin can be increased when it is combined with Hycanthone.Approved, Investigational
HydrocodoneThe serum concentration of Hydrocodone can be decreased when it is combined with Rifampicin.Approved, Illicit
HydrocortisoneThe serum concentration of Hydrocortisone can be decreased when it is combined with Rifampicin.Approved, Vet Approved
Hydrocortisone aceponateThe metabolism of Hydrocortisone aceponate can be increased when combined with Rifampicin.Experimental, Vet Approved
Hydrocortisone acetateThe metabolism of Hydrocortisone acetate can be increased when combined with Rifampicin.Approved, Vet Approved
Hydrocortisone butyrateThe metabolism of Hydrocortisone butyrate can be increased when combined with Rifampicin.Approved, Vet Approved
Hydrocortisone cypionateThe metabolism of Hydrocortisone cypionate can be increased when combined with Rifampicin.Approved, Vet Approved
Hydrocortisone phosphateThe metabolism of Hydrocortisone phosphate can be increased when combined with Rifampicin.Approved, Vet Approved
Hydrocortisone probutateThe metabolism of Hydrocortisone probutate can be increased when combined with Rifampicin.Approved, Vet Approved
Hydrocortisone succinateThe metabolism of Hydrocortisone succinate can be increased when combined with Rifampicin.Approved
Hydrocortisone valerateThe metabolism of Hydrocortisone valerate can be increased when combined with Rifampicin.Approved, Vet Approved
HydromorphoneThe metabolism of Hydromorphone can be increased when combined with Rifampicin.Approved, Illicit
HydrotalciteHydrotalcite can cause a decrease in the absorption of Rifampicin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Experimental, Investigational
HydroxychloroquineThe serum concentration of Rifampicin can be increased when it is combined with Hydroxychloroquine.Approved
HydroxyprogesteroneThe metabolism of Hydroxyprogesterone can be increased when combined with Rifampicin.Experimental
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be increased when combined with Rifampicin.Approved, Investigational
HydroxyureaThe serum concentration of Hydroxyurea can be increased when it is combined with Rifampicin.Approved
HypoxanthineThe metabolism of Hypoxanthine can be increased when combined with Rifampicin.Experimental
IbrutinibThe serum concentration of Ibrutinib can be decreased when it is combined with Rifampicin.Approved
IbuprofenThe serum concentration of Ibuprofen can be decreased when it is combined with Rifampicin.Approved
IcotinibThe metabolism of Icotinib can be increased when combined with Rifampicin.Approved, Investigational
IdelalisibThe serum concentration of Idelalisib can be decreased when it is combined with Rifampicin.Approved
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be increased when Ifosfamide is used in combination with Rifampicin.Approved
IloperidoneThe metabolism of Iloperidone can be increased when combined with Rifampicin.Approved
ImatinibThe serum concentration of Imatinib can be decreased when it is combined with Rifampicin.Approved
ImidafenacinThe metabolism of Imidafenacin can be increased when combined with Rifampicin.Approved, Investigational
ImipramineThe metabolism of Imipramine can be increased when combined with Rifampicin.Approved
ImiquimodThe metabolism of Imiquimod can be increased when combined with Rifampicin.Approved, Investigational
IndacaterolThe serum concentration of Indacaterol can be decreased when it is combined with Rifampicin.Approved
IndapamideThe metabolism of Indapamide can be increased when combined with Rifampicin.Approved
IndinavirThe serum concentration of Indinavir can be decreased when it is combined with Rifampicin.Approved
IndomethacinThe serum concentration of Indomethacin can be decreased when it is combined with Rifampicin.Approved, Investigational
Inotuzumab ozogamicinThe serum concentration of Inotuzumab ozogamicin can be increased when it is combined with Rifampicin.Approved, Investigational
IpecacThe metabolism of Ipecac can be increased when combined with Rifampicin.Approved, Withdrawn
IpratropiumThe metabolism of Ipratropium can be increased when combined with Rifampicin.Approved
IrbesartanThe metabolism of Irbesartan can be increased when combined with Rifampicin.Approved, Investigational
IrinotecanThe serum concentration of Irinotecan can be decreased when it is combined with Rifampicin.Approved, Investigational
IsavuconazoleThe serum concentration of Isavuconazole can be decreased when it is combined with Rifampicin.Approved, Investigational
IsavuconazoniumThe serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Rifampicin resulting in a loss in efficacy.Approved, Investigational
IsoniazidThe therapeutic efficacy of Isoniazid can be decreased when used in combination with Rifampicin.Approved, Investigational
IsoniazidThe metabolism of Rifampicin can be decreased when combined with Isoniazid.Approved, Investigational
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be increased when combined with Rifampicin.Approved, Investigational
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be increased when combined with Rifampicin.Approved
IsradipineThe metabolism of Isradipine can be increased when combined with Rifampicin.Approved, Investigational
ItraconazoleThe serum concentration of Itraconazole can be decreased when it is combined with Rifampicin.Approved, Investigational
IvabradineThe serum concentration of Ivabradine can be decreased when it is combined with Rifampicin.Approved
IvacaftorThe serum concentration of Ivacaftor can be decreased when it is combined with Rifampicin.Approved
IvermectinThe metabolism of Ivermectin can be increased when combined with Rifampicin.Approved, Investigational, Vet Approved
IvosidenibThe metabolism of Ivosidenib can be increased when combined with Rifampicin.Approved, Investigational
IxabepiloneThe serum concentration of Ixabepilone can be decreased when it is combined with Rifampicin.Approved, Investigational
IxazomibThe serum concentration of Ixazomib can be decreased when it is combined with Rifampicin.Approved, Investigational
KetamineThe metabolism of Ketamine can be increased when combined with Rifampicin.Approved, Vet Approved
KetazolamThe metabolism of Ketazolam can be increased when combined with Rifampicin.Approved
KetobemidoneThe metabolism of Ketobemidone can be increased when combined with Rifampicin.Approved, Investigational
KetoconazoleThe risk or severity of liver damage can be increased when Rifampicin is combined with Ketoconazole.Approved, Investigational
KetoprofenThe serum concentration of Ketoprofen can be decreased when it is combined with Rifampicin.Approved, Vet Approved
LacidipineThe serum concentration of Lacidipine can be decreased when it is combined with Rifampicin.Approved, Investigational
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Rifampicin.Approved, Investigational
LamotrigineThe metabolism of Lamotrigine can be increased when combined with Rifampicin.Approved, Investigational
LaniquidarThe serum concentration of Rifampicin can be increased when it is combined with Laniquidar.Investigational
LansoprazoleLansoprazole can cause a decrease in the absorption of Rifampicin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
LapatinibThe serum concentration of Lapatinib can be decreased when it is combined with Rifampicin.Approved, Investigational
LaquinimodThe metabolism of Laquinimod can be increased when combined with Rifampicin.Investigational
LedipasvirThe serum concentration of Ledipasvir can be decreased when it is combined with Rifampicin.Approved
LeflunomideThe serum concentration of the active metabolites of Leflunomide can be increased when Leflunomide is used in combination with Rifampicin.Approved, Investigational
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Rifampicin.Approved
LenvatinibThe risk or severity of liver damage can be increased when Rifampicin is combined with Lenvatinib.Approved, Investigational
LercanidipineThe metabolism of Lercanidipine can be increased when combined with Rifampicin.Approved, Investigational
LetermovirThe serum concentration of Letermovir can be decreased when it is combined with Rifampicin.Approved, Investigational
LetrozoleThe metabolism of Letrozole can be increased when combined with Rifampicin.Approved, Investigational
LeuprolideThe metabolism of Leuprolide can be increased when combined with Rifampicin.Approved, Investigational
LevetiracetamThe metabolism of Levetiracetam can be increased when combined with Rifampicin.Approved, Investigational
LevobupivacaineThe metabolism of Levobupivacaine can be increased when combined with Rifampicin.Approved, Investigational
LevocetirizineThe metabolism of Levocetirizine can be increased when combined with Rifampicin.Approved
LevofloxacinThe serum concentration of Levofloxacin can be increased when it is combined with Rifampicin.Approved, Investigational
LevomenolThe excretion of Levomenol can be decreased when combined with Rifampicin.Approved, Experimental
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be increased when combined with Rifampicin.Approved, Investigational
LevomilnacipranThe metabolism of Levomilnacipran can be increased when combined with Rifampicin.Approved, Investigational
LevonorgestrelThe metabolism of Levonorgestrel can be increased when combined with Rifampicin.Approved, Investigational
LevosalbutamolThe excretion of Levosalbutamol can be decreased when combined with Rifampicin.Approved, Investigational
LidocaineThe metabolism of Lidocaine can be increased when combined with Rifampicin.Approved, Vet Approved
LidoflazineThe metabolism of Lidoflazine can be increased when combined with Rifampicin.Experimental
LinagliptinThe serum concentration of Linagliptin can be decreased when it is combined with Rifampicin.Approved
LiothyronineThe serum concentration of Liothyronine can be decreased when it is combined with Rifampicin.Approved, Vet Approved
LiotrixThe serum concentration of Liotrix can be decreased when it is combined with Rifampicin.Approved
LisofyllineThe metabolism of Lisofylline can be increased when combined with Rifampicin.Investigational
LisurideThe metabolism of Lisuride can be increased when combined with Rifampicin.Approved, Investigational
LobeglitazoneThe metabolism of Lobeglitazone can be increased when combined with Rifampicin.Approved, Investigational
LofepramineThe metabolism of Lofepramine can be increased when combined with Rifampicin.Experimental
LofexidineThe metabolism of Lofexidine can be increased when combined with Rifampicin.Approved, Investigational
LomerizineThe metabolism of Lomerizine can be increased when combined with Rifampicin.Experimental
LomitapideThe metabolism of Lomitapide can be increased when combined with Rifampicin.Approved, Investigational
LonafarnibThe serum concentration of Rifampicin can be increased when it is combined with Lonafarnib.Investigational
LoperamideThe metabolism of Loperamide can be increased when combined with Rifampicin.Approved
LopinavirThe risk or severity of adverse effects can be increased when Rifampicin is combined with Lopinavir.Approved
LoratadineThe metabolism of Loratadine can be increased when combined with Rifampicin.Approved, Investigational
LorcaserinThe metabolism of Lorcaserin can be increased when combined with Rifampicin.Approved
LorpiprazoleThe serum concentration of Rifampicin can be increased when it is combined with Lorpiprazole.Approved
LoteprednolThe metabolism of Loteprednol can be increased when combined with Rifampicin.Approved
LovastatinThe serum concentration of Lovastatin can be decreased when it is combined with Rifampicin.Approved, Investigational
LoxapineThe serum concentration of Rifampicin can be increased when it is combined with Loxapine.Approved
LuliconazoleThe serum concentration of Rifampicin can be increased when it is combined with Luliconazole.Approved
LumacaftorThe serum concentration of Rifampicin can be decreased when it is combined with Lumacaftor.Approved
LumefantrineThe serum concentration of Lumefantrine can be decreased when it is combined with Rifampicin.Approved
LurasidoneThe serum concentration of Lurasidone can be decreased when it is combined with Rifampicin.Approved, Investigational
LusutrombopagThe serum concentration of Lusutrombopag can be increased when it is combined with Rifampicin.Approved, Investigational
LynestrenolThe metabolism of Lynestrenol can be increased when combined with Rifampicin.Approved, Investigational
Lysergic Acid DiethylamideThe metabolism of Lysergic Acid Diethylamide can be increased when combined with Rifampicin.Illicit, Investigational, Withdrawn
MacimorelinThe serum concentration of Macimorelin can be decreased when it is combined with Rifampicin.Approved, Investigational
MacitentanThe serum concentration of Macitentan can be decreased when it is combined with Rifampicin.Approved
MagaldrateMagaldrate can cause a decrease in the absorption of Rifampicin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Withdrawn
Magnesium carbonateMagnesium carbonate can cause a decrease in the absorption of Rifampicin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
Magnesium hydroxideMagnesium hydroxide can cause a decrease in the absorption of Rifampicin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
Magnesium oxideMagnesium oxide can cause a decrease in the absorption of Rifampicin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Magnesium peroxideMagnesium peroxide can cause a decrease in the absorption of Rifampicin resulting in a reduced serum concentration and potentially a decrease in efficacy.Experimental
Magnesium silicateMagnesium silicate can cause a decrease in the absorption of Rifampicin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Magnesium sulfateThe metabolism of Magnesium sulfate can be increased when combined with Rifampicin.Approved, Investigational, Vet Approved
Magnesium TrisilicateMagnesium Trisilicate can cause a decrease in the absorption of Rifampicin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
ManidipineThe metabolism of Manidipine can be increased when combined with Rifampicin.Approved, Investigational
MaprotilineThe metabolism of Maprotiline can be increased when combined with Rifampicin.Approved, Investigational
MaravirocThe serum concentration of Maraviroc can be decreased when it is combined with Rifampicin.Approved, Investigational
MebendazoleThe metabolism of Mebendazole can be increased when combined with Rifampicin.Approved, Vet Approved
Medical CannabisThe metabolism of Medical Cannabis can be increased when combined with Rifampicin.Experimental, Investigational
MedrogestoneThe metabolism of Medrogestone can be increased when combined with Rifampicin.Approved
Medroxyprogesterone acetateThe metabolism of Medroxyprogesterone acetate can be increased when combined with Rifampicin.Approved, Investigational
MedrysoneThe metabolism of Medrysone can be increased when combined with Rifampicin.Approved
MefloquineThe metabolism of Mefloquine can be increased when combined with Rifampicin.Approved, Investigational
Megestrol acetateThe metabolism of Megestrol acetate can be increased when combined with Rifampicin.Approved, Investigational, Vet Approved
MelatoninThe metabolism of Melatonin can be increased when combined with Rifampicin.Approved, Nutraceutical, Vet Approved
MelengestrolThe metabolism of Melengestrol can be increased when combined with Rifampicin.Vet Approved
MelitracenThe metabolism of Melitracen can be increased when combined with Rifampicin.Experimental, Investigational
MeloxicamThe metabolism of Meloxicam can be increased when combined with Rifampicin.Approved, Vet Approved
MelphalanThe serum concentration of Melphalan can be increased when it is combined with Rifampicin.Approved
MentholThe metabolism of Menthol can be increased when combined with Rifampicin.Approved
MephenytoinThe metabolism of Mephenytoin can be increased when combined with Rifampicin.Investigational, Withdrawn
MeprednisoneThe metabolism of Meprednisone can be increased when combined with Rifampicin.Approved, Investigational
MestranolThe metabolism of Mestranol can be increased when combined with Rifampicin.Approved
MetahexamideThe serum concentration of Metahexamide can be decreased when it is combined with Rifampicin.Experimental
MethadoneThe metabolism of Methadone can be increased when combined with Rifampicin.Approved
MethaqualoneThe metabolism of Methaqualone can be increased when combined with Rifampicin.Illicit, Withdrawn
MethohexitalThe metabolism of Methohexital can be increased when combined with Rifampicin.Approved
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Rifampicin.Approved
MethoxsalenThe metabolism of Methoxsalen can be increased when combined with Rifampicin.Approved
MethoxyfluraneThe metabolism of Methoxyflurane can be increased when combined with Rifampicin.Approved, Investigational, Vet Approved
MethsuximideThe metabolism of Methsuximide can be increased when combined with Rifampicin.Approved
MethylergometrineThe metabolism of Methylergometrine can be increased when combined with Rifampicin.Approved
MethylphenobarbitalThe metabolism of Methylphenobarbital can be increased when combined with Rifampicin.Approved
MethylprednisoloneThe serum concentration of Methylprednisolone can be decreased when it is combined with Rifampicin.Approved, Vet Approved
MethyltestosteroneThe metabolism of Methyltestosterone can be increased when combined with Rifampicin.Approved
MetronidazoleThe serum concentration of Metronidazole can be decreased when it is combined with Rifampicin.Approved
MexiletineThe metabolism of Mexiletine can be increased when combined with Rifampicin.Approved, Investigational
MianserinThe metabolism of Mianserin can be increased when combined with Rifampicin.Approved, Investigational
MibefradilThe metabolism of Mibefradil can be increased when combined with Rifampicin.Investigational, Withdrawn
MiconazoleThe metabolism of Miconazole can be increased when combined with Rifampicin.Approved, Investigational, Vet Approved
MidazolamThe metabolism of Midazolam can be increased when combined with Rifampicin.Approved, Illicit
MidecamycinThe metabolism of Midecamycin can be increased when combined with Rifampicin.Approved
MidostaurinThe metabolism of Midostaurin can be increased when combined with Rifampicin.Approved, Investigational
MifepristoneThe serum concentration of Mifepristone can be decreased when it is combined with Rifampicin.Approved, Investigational
MirabegronThe serum concentration of Mirabegron can be decreased when it is combined with Rifampicin.Approved
MirtazapineThe metabolism of Mirtazapine can be increased when combined with Rifampicin.Approved
MitomycinThe serum concentration of Mitomycin can be increased when it is combined with Rifampicin.Approved
MitotaneThe serum concentration of Rifampicin can be decreased when it is combined with Mitotane.Approved
MitoxantroneThe serum concentration of Mitoxantrone can be increased when it is combined with Rifampicin.Approved, Investigational
ModafinilThe metabolism of Modafinil can be increased when combined with Rifampicin.Approved, Investigational
MometasoneThe metabolism of Mometasone can be increased when combined with Rifampicin.Approved, Vet Approved
Mometasone furoateThe metabolism of Mometasone furoate can be increased when combined with Rifampicin.Approved, Vet Approved
MonensinThe serum concentration of Rifampicin can be increased when it is combined with Monensin.Vet Approved
MontelukastThe metabolism of Montelukast can be increased when combined with Rifampicin.Approved
MorphineThe serum concentration of Morphine can be decreased when it is combined with Rifampicin.Approved, Investigational
MoxidectinThe serum concentration of Moxidectin can be increased when it is combined with Rifampicin.Approved, Investigational, Vet Approved
MuraglitazarThe serum concentration of Muraglitazar can be decreased when it is combined with Rifampicin.Investigational
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be decreased when it is combined with Rifampicin.Approved, Investigational
NabiximolsThe metabolism of Nabiximols can be increased when combined with Rifampicin.Approved, Investigational
NabumetoneThe metabolism of Nabumetone can be increased when combined with Rifampicin.Approved
NadololThe serum concentration of Nadolol can be increased when it is combined with Rifampicin.Approved
NafcillinThe serum concentration of Rifampicin can be decreased when it is combined with Nafcillin.Approved, Investigational
NaftopidilThe metabolism of Naftopidil can be increased when combined with Rifampicin.Investigational
NaloxegolThe serum concentration of Naloxegol can be decreased when it is combined with Rifampicin.Approved
NaloxoneThe serum concentration of Naloxone can be decreased when it is combined with Rifampicin.Approved, Vet Approved
NaltrexoneThe serum concentration of Naltrexone can be decreased when it is combined with Rifampicin.Approved, Investigational, Vet Approved
NaproxenThe serum concentration of Naproxen can be decreased when it is combined with Rifampicin.Approved, Vet Approved
NateglinideThe metabolism of Nateglinide can be increased when combined with Rifampicin.Approved, Investigational
NefazodoneThe metabolism of Nefazodone can be increased when combined with Rifampicin.Approved, Withdrawn
NelfinavirThe serum concentration of Nelfinavir can be decreased when it is combined with Rifampicin.Approved
NeostigmineThe serum concentration of Neostigmine can be increased when it is combined with Rifampicin.Approved, Vet Approved
NeratinibThe metabolism of Neratinib can be increased when combined with Rifampicin.Approved, Investigational
NetoglitazoneThe metabolism of Netoglitazone can be increased when combined with Rifampicin.Experimental
NetupitantThe serum concentration of Netupitant can be decreased when it is combined with Rifampicin.Approved, Investigational
NevirapineThe serum concentration of Nevirapine can be decreased when it is combined with Rifampicin.Approved
NicardipineThe metabolism of Nicardipine can be increased when combined with Rifampicin.Approved, Investigational
NicotineThe metabolism of Nicotine can be increased when combined with Rifampicin.Approved
NifedipineThe serum concentration of Nifedipine can be decreased when it is combined with Rifampicin.Approved
NigericinThe serum concentration of Rifampicin can be increased when it is combined with Nigericin.Experimental
NiguldipineThe metabolism of Niguldipine can be increased when combined with Rifampicin.Experimental
NilotinibThe serum concentration of Nilotinib can be decreased when it is combined with Rifampicin.Approved, Investigational
NiludipineThe metabolism of Niludipine can be increased when combined with Rifampicin.Experimental
NilvadipineThe metabolism of Nilvadipine can be increased when combined with Rifampicin.Approved, Investigational
NimesulideThe metabolism of Nimesulide can be increased when combined with Rifampicin.Approved, Investigational, Withdrawn
NimodipineThe serum concentration of Nimodipine can be decreased when it is combined with Rifampicin.Approved, Investigational
NintedanibThe serum concentration of Nintedanib can be decreased when it is combined with Rifampicin.Approved
NisoldipineThe serum concentration of Nisoldipine can be decreased when it is combined with Rifampicin.Approved
NitrazepamThe serum concentration of Nitrazepam can be decreased when it is combined with Rifampicin.Approved
NitrendipineThe metabolism of Nitrendipine can be increased when combined with Rifampicin.Approved, Investigational
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Rifampicin.Approved
NomegestrolThe metabolism of Nomegestrol can be increased when combined with Rifampicin.Approved
Nomegestrol acetateThe metabolism of Nomegestrol acetate can be increased when combined with Rifampicin.Approved, Investigational
NordazepamThe metabolism of Nordazepam can be increased when combined with Rifampicin.Approved
NorelgestrominThe metabolism of Norelgestromin can be increased when combined with Rifampicin.Approved, Investigational
NorethisteroneThe metabolism of Norethisterone can be increased when combined with Rifampicin.Approved
NorethynodrelThe metabolism of Norethynodrel can be increased when combined with Rifampicin.Approved
NorgestimateThe metabolism of Norgestimate can be increased when combined with Rifampicin.Approved, Investigational
NorgestrelThe metabolism of Norgestrel can be increased when combined with Rifampicin.Approved
NorgestrienoneThe metabolism of Norgestrienone can be increased when combined with Rifampicin.Experimental
NortriptylineThe metabolism of Nortriptyline can be increased when combined with Rifampicin.Approved
NylidrinThe metabolism of Nylidrin can be increased when combined with Rifampicin.Approved
OctreotideThe serum concentration of Octreotide can be increased when it is combined with Rifampicin.Approved, Investigational
OdanacatibThe metabolism of Odanacatib can be increased when combined with Rifampicin.Investigational
OlanzapineThe serum concentration of Olanzapine can be decreased when it is combined with Rifampicin.Approved, Investigational
OlaparibThe serum concentration of Olaparib can be decreased when it is combined with Rifampicin.Approved
OlmesartanThe excretion of Olmesartan can be decreased when combined with Rifampicin.Approved, Investigational
OlopatadineThe metabolism of Olopatadine can be increased when combined with Rifampicin.Approved
OmbitasvirThe serum concentration of Ombitasvir can be decreased when it is combined with Rifampicin.Approved, Investigational
OmeprazoleThe serum concentration of Omeprazole can be decreased when it is combined with Rifampicin.Approved, Investigational, Vet Approved
OndansetronThe metabolism of Ondansetron can be increased when combined with Rifampicin.Approved
ONT-093The serum concentration of Rifampicin can be increased when it is combined with ONT-093.Investigational
OpiumThe metabolism of Opium can be increased when combined with Rifampicin.Approved, Illicit
OrphenadrineThe metabolism of Orphenadrine can be increased when combined with Rifampicin.Approved
OsimertinibThe serum concentration of Osimertinib can be decreased when it is combined with Rifampicin.Approved
OspemifeneThe metabolism of Ospemifene can be increased when combined with Rifampicin.Approved, Investigational
OtiloniumThe metabolism of Otilonium can be increased when combined with Rifampicin.Experimental, Investigational
OxazepamThe metabolism of Oxazepam can be increased when combined with Rifampicin.Approved
OxcarbazepineThe serum concentration of Oxcarbazepine can be decreased when it is combined with Rifampicin.Approved
OxtriphyllineThe metabolism of Oxtriphylline can be increased when combined with Rifampicin.Approved
OxybutyninThe metabolism of Oxybutynin can be increased when combined with Rifampicin.Approved, Investigational
OxycodoneThe serum concentration of Oxycodone can be decreased when it is combined with Rifampicin.Approved, Illicit, Investigational
OxymorphoneThe metabolism of Oxymorphone can be increased when combined with Rifampicin.Approved, Investigational, Vet Approved
PaclitaxelRifampicin may decrease the excretion rate of Paclitaxel which could result in a higher serum level.Approved, Vet Approved
PalbociclibThe serum concentration of Palbociclib can be decreased when it is combined with Rifampicin.Approved, Investigational
PaliperidoneThe serum concentration of Paliperidone can be decreased when it is combined with Rifampicin.Approved
PalonosetronThe metabolism of Palonosetron can be increased when combined with Rifampicin.Approved, Investigational
PanobinostatThe serum concentration of Panobinostat can be decreased when it is combined with Rifampicin.Approved, Investigational
PantoprazolePantoprazole can cause a decrease in the absorption of Rifampicin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
ParamethadioneThe metabolism of Paramethadione can be increased when combined with Rifampicin.Approved
ParamethasoneThe metabolism of Paramethasone can be increased when combined with Rifampicin.Approved
ParecoxibThe metabolism of Parecoxib can be increased when combined with Rifampicin.Approved
ParicalcitolThe metabolism of Paricalcitol can be increased when combined with Rifampicin.Approved, Investigational
ParitaprevirThe serum concentration of Paritaprevir can be decreased when it is combined with Rifampicin.Approved, Investigational
ParoxetineThe serum concentration of Rifampicin can be increased when it is combined with Paroxetine.Approved, Investigational
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Rifampicin.Approved
PefloxacinThe metabolism of Pefloxacin can be increased when combined with Rifampicin.Approved
PenfluridolThe metabolism of Penfluridol can be increased when combined with Rifampicin.Experimental
PenicillamineThe excretion of Penicillamine can be decreased when combined with Rifampicin.Approved
PentamidineThe metabolism of Pentamidine can be increased when combined with Rifampicin.Approved, Investigational
PentazocineThe serum concentration of Pentazocine can be increased when it is combined with Rifampicin.Approved, Vet Approved
PentobarbitalThe metabolism of Pentobarbital can be increased when combined with Rifampicin.Approved, Investigational, Vet Approved
PentoxifyllineThe metabolism of Pentoxifylline can be increased when combined with Rifampicin.Approved, Investigational
PerampanelThe serum concentration of Perampanel can be decreased when it is combined with Rifampicin.Approved
PergolideThe metabolism of Pergolide can be increased when combined with Rifampicin.Approved, Investigational, Vet Approved, Withdrawn
PerhexilineThe metabolism of Perhexiline can be increased when combined with Rifampicin.Approved, Investigational
PermethrinThe metabolism of Permethrin can be increased when combined with Rifampicin.Approved, Investigational
PerospironeThe metabolism of Perospirone can be increased when combined with Rifampicin.Approved
PerphenazineThe metabolism of Perphenazine can be increased when combined with Rifampicin.Approved
PethidineThe metabolism of Pethidine can be increased when combined with Rifampicin.Approved
PhenacetinThe metabolism of Phenacetin can be increased when combined with Rifampicin.Withdrawn
PhenobarbitalThe metabolism of Rifampicin can be increased when combined with Phenobarbital.Approved, Investigational
PhenothiazineThe serum concentration of Phenothiazine can be increased when it is combined with Rifampicin.Vet Approved
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be increased when combined with Rifampicin.Approved
PhenprocoumonThe metabolism of Phenprocoumon can be increased when combined with Rifampicin.Approved, Investigational
PhenylbutazoneThe metabolism of Phenylbutazone can be increased when combined with Rifampicin.Approved, Vet Approved
PhenytoinThe serum concentration of Phenytoin can be decreased when it is combined with Rifampicin.Approved, Vet Approved
PibrentasvirThe serum concentration of Pibrentasvir can be increased when it is combined with Rifampicin.Approved, Investigational
Picosulfuric acidThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Rifampicin.Approved
PilocarpineThe metabolism of Pilocarpine can be increased when combined with Rifampicin.Approved, Investigational
PimecrolimusThe metabolism of Pimecrolimus can be increased when combined with Rifampicin.Approved, Investigational
PimobendanThe metabolism of Pimobendan can be increased when combined with Rifampicin.Vet Approved
PimozideThe metabolism of Pimozide can be increased when combined with Rifampicin.Approved
PinacidilThe metabolism of Pinacidil can be increased when combined with Rifampicin.Approved
PinaveriumThe metabolism of Pinaverium can be increased when combined with Rifampicin.Approved
PioglitazoneThe metabolism of Pioglitazone can be increased when combined with Rifampicin.Approved, Investigational
Pipemidic acidThe metabolism of Pipemidic acid can be increased when combined with Rifampicin.Experimental
PiperaquineThe metabolism of Piperaquine can be increased when combined with Rifampicin.Approved, Investigational
PipotiazineThe metabolism of Pipotiazine can be increased when combined with Rifampicin.Approved, Investigational
PirfenidoneThe serum concentration of Pirfenidone can be decreased when it is combined with Rifampicin.Approved, Investigational
PiroxicamThe metabolism of Piroxicam can be increased when combined with Rifampicin.Approved, Investigational
PitavastatinThe excretion of Pitavastatin can be decreased when combined with Rifampicin.Approved
PitolisantThe serum concentration of Pitolisant can be decreased when it is combined with Rifampicin.Approved, Investigational
PodofiloxThe metabolism of Podofilox can be increased when combined with Rifampicin.Approved
PomalidomideThe metabolism of Pomalidomide can be increased when combined with Rifampicin.Approved
PonatinibThe serum concentration of Ponatinib can be decreased when it is combined with Rifampicin.Approved, Investigational
PosaconazoleThe metabolism of Posaconazole can be increased when combined with Rifampicin.Approved, Investigational, Vet Approved
PrasteroneThe metabolism of Prasterone can be increased when combined with Rifampicin.Approved, Investigational, Nutraceutical
PrasugrelRifampicin may decrease the antiplatelet activities of Prasugrel.Approved
PravastatinRifampicin may decrease the excretion rate of Pravastatin which could result in a higher serum level.Approved
PrazepamThe metabolism of Prazepam can be increased when combined with Rifampicin.Approved, Illicit
PraziquantelThe serum concentration of Praziquantel can be decreased when it is combined with Rifampicin.Approved, Investigational, Vet Approved
PrazosinThe serum concentration of Prazosin can be increased when it is combined with Rifampicin.Approved
PrednicarbateThe metabolism of Prednicarbate can be increased when combined with Rifampicin.Approved, Investigational
PrednisoloneThe serum concentration of Prednisolone can be decreased when it is combined with Rifampicin.Approved, Vet Approved
PrednisoneThe serum concentration of Prednisone can be decreased when it is combined with Rifampicin.Approved, Vet Approved
PrednylideneThe metabolism of Prednylidene can be increased when combined with Rifampicin.Experimental
PregabalinThe metabolism of Pregabalin can be increased when combined with Rifampicin.Approved, Illicit, Investigational
PregnenoloneThe metabolism of Pregnenolone can be increased when combined with Rifampicin.Approved, Experimental, Investigational
PrenylamineThe metabolism of Prenylamine can be increased when combined with Rifampicin.Withdrawn
PrimaquineThe metabolism of Primaquine can be increased when combined with Rifampicin.Approved
PrimidoneThe metabolism of Rifampicin can be increased when combined with Primidone.Approved, Vet Approved
ProchlorperazineThe metabolism of Prochlorperazine can be increased when combined with Rifampicin.Approved, Vet Approved
ProgesteroneThe risk or severity of liver damage can be increased when Rifampicin is combined with Progesterone.Approved, Vet Approved
ProguanilThe metabolism of Proguanil can be increased when combined with Rifampicin.Approved
PromazineThe metabolism of Promazine can be increased when combined with Rifampicin.Approved, Vet Approved
PromegestoneThe metabolism of Promegestone can be increased when combined with Rifampicin.Experimental
PromethazineThe serum concentration of Rifampicin can be increased when it is combined with Promethazine.Approved, Investigational
PropafenoneThe serum concentration of Propafenone can be decreased when it is combined with Rifampicin.Approved
PropiverineThe metabolism of Propiverine can be increased when combined with Rifampicin.Approved, Investigational
PropofolRifampicin may increase the hypotensive activities of Propofol.Approved, Investigational, Vet Approved
PropranololThe metabolism of Propranolol can be increased when combined with Rifampicin.Approved, Investigational
ProtriptylineThe serum concentration of Rifampicin can be increased when it is combined with Protriptyline.Approved
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Rifampicin.Approved
PyrazinamidePyrazinamide may increase the hepatotoxic activities of Rifampicin.Approved, Investigational
QuazepamThe metabolism of Quazepam can be increased when combined with Rifampicin.Approved, Illicit
QuercetinThe serum concentration of Rifampicin can be increased when it is combined with Quercetin.Experimental, Investigational
QuetiapineThe serum concentration of Quetiapine can be decreased when it is combined with Rifampicin.Approved
QuinacrineThe metabolism of Quinacrine can be increased when combined with Rifampicin.Approved, Investigational
QuingestanolThe metabolism of Quingestanol can be increased when combined with Rifampicin.Experimental
QuinidineThe metabolism of Quinidine can be increased when combined with Rifampicin.Approved, Investigational
QuinineThe serum concentration of Quinine can be decreased when it is combined with Rifampicin.Approved
RabeprazoleRabeprazole can cause a decrease in the absorption of Rifampicin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
RaloxifeneThe serum concentration of Raloxifene can be decreased when it is combined with Rifampicin.Approved, Investigational
RamelteonThe metabolism of Ramelteon can be increased when combined with Rifampicin.Approved, Investigational
RamosetronThe metabolism of Ramosetron can be increased when combined with Rifampicin.Approved, Investigational
RanitidineThe metabolism of Ranitidine can be increased when combined with Rifampicin.Approved
RasagilineThe metabolism of Rasagiline can be increased when combined with Rifampicin.Approved
ReboxetineThe metabolism of Reboxetine can be increased when combined with Rifampicin.Approved, Investigational
RegorafenibThe serum concentration of Regorafenib can be decreased when it is combined with Rifampicin.Approved
RepaglinideThe serum concentration of Repaglinide can be decreased when it is combined with Rifampicin.Approved, Investigational
ReserpineThe risk or severity of liver damage can be increased when Rifampicin is combined with Reserpine.Approved, Investigational
ResveratrolThe metabolism of Resveratrol can be increased when combined with Rifampicin.Approved, Experimental, Investigational
RetapamulinThe metabolism of Retapamulin can be increased when combined with Rifampicin.Approved
Reversin 121The serum concentration of Rifampicin can be increased when it is combined with Reversin 121.Experimental
Rhodamine 6GThe serum concentration of Rhodamine 6G can be increased when it is combined with Rifampicin.Experimental
RibociclibThe serum concentration of Ribociclib can be decreased when it is combined with Rifampicin.Approved, Investigational
RifabutinThe metabolism of Rifabutin can be increased when combined with Rifampicin.Approved, Investigational
RifamycinThe metabolism of Rifamycin can be increased when combined with Rifampicin.Investigational
RifapentineThe metabolism of Rifapentine can be increased when combined with Rifampicin.Approved, Investigational
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Rifampicin.Approved, Investigational
RilpivirineThe serum concentration of Rilpivirine can be decreased when it is combined with Rifampicin.Approved
RiluzoleThe metabolism of Riluzole can be increased when combined with Rifampicin.Approved, Investigational
RimexoloneThe metabolism of Rimexolone can be increased when combined with Rifampicin.Approved
RimonabantThe metabolism of Rimonabant can be increased when combined with Rifampicin.Approved, Investigational
RiociguatThe metabolism of Riociguat can be increased when combined with Rifampicin.Approved
RisperidoneThe metabolism of Risperidone can be increased when combined with Rifampicin.Approved, Investigational
RitonavirThe serum concentration of Ritonavir can be decreased when it is combined with Rifampicin.Approved, Investigational
RivaroxabanThe serum concentration of Rivaroxaban can be decreased when it is combined with Rifampicin.Approved
RivoglitazoneThe metabolism of Rivoglitazone can be increased when combined with Rifampicin.Experimental, Investigational
RofecoxibThe metabolism of Rofecoxib can be increased when combined with Rifampicin.Approved, Investigational, Withdrawn
RolapitantThe serum concentration of Rolapitant can be decreased when it is combined with Rifampicin.Approved, Investigational
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Rifampicin.Approved, Investigational
RopiniroleThe metabolism of Ropinirole can be increased when combined with Rifampicin.Approved, Investigational
RopivacaineThe metabolism of Ropivacaine can be increased when combined with Rifampicin.Approved
RosiglitazoneThe metabolism of Rosiglitazone can be increased when combined with Rifampicin.Approved, Investigational
RosuvastatinRifampicin may decrease the excretion rate of Rosuvastatin which could result in a higher serum level.Approved
RotigotineThe metabolism of Rotigotine can be increased when combined with Rifampicin.Approved
RoxithromycinThe metabolism of Roxithromycin can be increased when combined with Rifampicin.Approved, Investigational, Withdrawn
RucaparibThe metabolism of Rucaparib can be increased when combined with Rifampicin.Approved, Investigational
RupatadineThe metabolism of Rupatadine can be increased when combined with Rifampicin.Approved
RuxolitinibThe metabolism of Ruxolitinib can be increased when combined with Rifampicin.Approved
SafinamideThe metabolism of Safinamide can be increased when combined with Rifampicin.Approved, Investigational
SalinomycinThe serum concentration of Rifampicin can be increased when it is combined with Salinomycin.Vet Approved
SalmeterolThe metabolism of Salmeterol can be increased when combined with Rifampicin.Approved
Salmonella typhi Ty21a live antigenThe therapeutic efficacy of Salmonella typhi Ty21a live antigen can be decreased when used in combination with Rifampicin.Approved
SaquinavirThe serum concentration of Saquinavir can be decreased when it is combined with Rifampicin.Approved, Investigational
SarilumabThe therapeutic efficacy of Rifampicin can be decreased when used in combination with Sarilumab.Approved, Investigational
SaxagliptinThe serum concentration of Saxagliptin can be decreased when it is combined with Rifampicin.Approved
SelegilineThe metabolism of Selegiline can be increased when combined with Rifampicin.Approved, Investigational, Vet Approved
SeletracetamThe metabolism of Seletracetam can be increased when combined with Rifampicin.Investigational
SelexipagThe metabolism of Selexipag can be increased when combined with Rifampicin.Approved
SeratrodastThe metabolism of Seratrodast can be increased when combined with Rifampicin.Approved
SertindoleThe metabolism of Sertindole can be increased when combined with Rifampicin.Approved, Investigational, Withdrawn
SertralineThe metabolism of Sertraline can be increased when combined with Rifampicin.Approved
SevofluraneThe metabolism of Sevoflurane can be increased when combined with Rifampicin.Approved, Vet Approved
SibutramineThe metabolism of Sibutramine can be increased when combined with Rifampicin.Approved, Illicit, Investigational, Withdrawn
SildenafilThe metabolism of Sildenafil can be increased when combined with Rifampicin.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Rifampicin.Approved
SiltuximabThe serum concentration of Rifampicin can be decreased when it is combined with Siltuximab.Approved, Investigational
SimeprevirThe serum concentration of Simeprevir can be decreased when it is combined with Rifampicin.Approved
SimvastatinThe serum concentration of Simvastatin can be decreased when it is combined with Rifampicin.Approved
SirolimusThe metabolism of Sirolimus can be increased when combined with Rifampicin.Approved, Investigational
SitagliptinThe metabolism of Sitagliptin can be increased when combined with Rifampicin.Approved, Investigational
Sodium bicarbonateSodium bicarbonate can cause a decrease in the absorption of Rifampicin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
SofosbuvirThe serum concentration of Sofosbuvir can be decreased when it is combined with Rifampicin.Approved
SolifenacinThe metabolism of Solifenacin can be increased when combined with Rifampicin.Approved
SomatostatinThe serum concentration of Somatostatin can be increased when it is combined with Rifampicin.Approved, Investigational
SonidegibThe serum concentration of Sonidegib can be decreased when it is combined with Rifampicin.Approved, Investigational
SorafenibThe serum concentration of Sorafenib can be decreased when it is combined with Rifampicin.Approved, Investigational
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Rifampicin.Approved, Investigational
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Rifampicin.Experimental
SpiramycinThe metabolism of Spiramycin can be increased when combined with Rifampicin.Approved
St. John's WortThe serum concentration of Rifampicin can be decreased when it is combined with St. John's Wort.Approved, Investigational, Nutraceutical
StanoloneThe serum concentration of Stanolone can be increased when it is combined with Rifampicin.Illicit, Investigational
Stanolone acetateThe serum concentration of Stanolone acetate can be increased when it is combined with Rifampicin.Experimental
StaurosporineThe serum concentration of Rifampicin can be increased when it is combined with Staurosporine.Experimental
StiripentolThe serum concentration of Rifampicin can be increased when it is combined with Stiripentol.Approved
SufentanilThe metabolism of Sufentanil can be increased when combined with Rifampicin.Approved, Investigational
SulfadiazineThe metabolism of Sulfadiazine can be increased when combined with Rifampicin.Approved, Investigational, Vet Approved
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be increased when combined with Rifampicin.Approved
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be increased when combined with Rifampicin.Approved
SumatriptanThe serum concentration of Sumatriptan can be increased when it is combined with Rifampicin.Approved, Investigational
SunitinibThe serum concentration of Sunitinib can be decreased when it is combined with Rifampicin.Approved, Investigational
SuprofenThe serum concentration of Suprofen can be decreased when it is combined with Rifampicin.Approved, Withdrawn
SuvorexantThe serum concentration of Suvorexant can be decreased when it is combined with Rifampicin.Approved, Investigational
Synthetic Conjugated Estrogens, AThe metabolism of Synthetic Conjugated Estrogens, A can be increased when combined with Rifampicin.Approved
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be increased when combined with Rifampicin.Approved
TacrineThe metabolism of Tacrine can be increased when combined with Rifampicin.Investigational, Withdrawn
TacrolimusThe metabolism of Tacrolimus can be increased when combined with Rifampicin.Approved, Investigational
TadalafilThe serum concentration of Tadalafil can be decreased when it is combined with Rifampicin.Approved, Investigational
TalinololThe serum concentration of Talinolol can be increased when it is combined with Rifampicin.Investigational
TamoxifenThe metabolism of Tamoxifen can be increased when combined with Rifampicin.Approved
TamsulosinThe metabolism of Tamsulosin can be increased when combined with Rifampicin.Approved, Investigational
TariquidarThe serum concentration of Rifampicin can be increased when it is combined with Tariquidar.Investigational
TasimelteonThe serum concentration of Tasimelteon can be decreased when it is combined with Rifampicin.Approved, Investigational
TasosartanThe metabolism of Tasosartan can be increased when combined with Rifampicin.Approved
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be increased when combined with Rifampicin.Experimental
Taurocholic AcidRifampicin may decrease the excretion rate of Taurocholic Acid which could result in a higher serum level.Experimental
Technetium Tc-99m mebrofeninThe excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Rifampicin.Approved
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Rifampicin.Approved, Investigational
TegafurThe metabolism of Tegafur can be increased when combined with Rifampicin.Approved, Investigational
TelithromycinThe metabolism of Telithromycin can be increased when combined with Rifampicin.Approved
TelmisartanThe serum concentration of Rifampicin can be increased when it is combined with Telmisartan.Approved, Investigational
TemazepamThe metabolism of Temazepam can be increased when combined with Rifampicin.Approved, Investigational
TemocaprilThe excretion of Temocapril can be decreased when combined with Rifampicin.Experimental, Investigational
TemsirolimusThe metabolism of Temsirolimus can be increased when combined with Rifampicin.Approved
TeniposideThe metabolism of Teniposide can be increased when combined with Rifampicin.Approved
TerbinafineThe serum concentration of Terbinafine can be decreased when it is combined with Rifampicin.Approved, Investigational, Vet Approved
TerfenadineThe metabolism of Terfenadine can be increased when combined with Rifampicin.Approved, Withdrawn
TergurideThe metabolism of Terguride can be increased when combined with Rifampicin.Experimental
TerodilineThe metabolism of Terodiline can be increased when combined with Rifampicin.Experimental
TesmilifeneThe metabolism of Tesmilifene can be increased when combined with Rifampicin.Investigational
TestosteroneThe metabolism of Testosterone can be increased when combined with Rifampicin.Approved, Investigational
Testosterone cypionateThe metabolism of Testosterone cypionate can be increased when combined with Rifampicin.Approved
Testosterone enanthateThe metabolism of Testosterone enanthate can be increased when combined with Rifampicin.Approved
Testosterone propionateThe metabolism of Testosterone propionate can be increased when combined with Rifampicin.Approved, Investigational, Vet Approved, Withdrawn
Testosterone undecanoateThe metabolism of Testosterone undecanoate can be increased when combined with Rifampicin.Approved, Investigational
TetracyclineThe metabolism of Tetracycline can be increased when combined with Rifampicin.Approved, Vet Approved
TetrahydropalmatineThe metabolism of Tetrahydropalmatine can be increased when combined with Rifampicin.Investigational
TetrandrineThe metabolism of Tetrandrine can be increased when combined with Rifampicin.Experimental
TezacaftorThe metabolism of Tezacaftor can be increased when combined with Rifampicin.Approved, Investigational
TheobromineThe metabolism of Theobromine can be increased when combined with Rifampicin.Approved, Investigational
TheophyllineThe metabolism of Theophylline can be increased when combined with Rifampicin.Approved
ThiamylalThe metabolism of Thiamylal can be increased when combined with Rifampicin.Approved, Vet Approved
ThiopentalThe metabolism of Thiopental can be increased when combined with Rifampicin.Approved, Vet Approved
ThioridazineThe metabolism of Thioridazine can be increased when combined with Rifampicin.Approved, Withdrawn
ThiotepaThe metabolism of Thiotepa can be increased when combined with Rifampicin.Approved, Investigational
ThiothixeneThe metabolism of Thiothixene can be increased when combined with Rifampicin.Approved
Thyroid, porcineThe serum concentration of Thyroid, porcine can be decreased when it is combined with Rifampicin.Approved
TiagabineThe serum concentration of Tiagabine can be decreased when it is combined with Rifampicin.Approved, Investigational
TianeptineThe metabolism of Tianeptine can be increased when combined with Rifampicin.Approved, Investigational
TicagrelorThe serum concentration of Ticagrelor can be decreased when it is combined with Rifampicin.Approved
TiclopidineThe metabolism of Ticlopidine can be increased when combined with Rifampicin.Approved
TimololThe serum concentration of Timolol can be increased when it is combined with Rifampicin.Approved
TinidazoleThe metabolism of Tinidazole can be increased when combined with Rifampicin.Approved, Investigational
TiotropiumThe metabolism of Tiotropium can be increased when combined with Rifampicin.Approved
TipifarnibThe serum concentration of Rifampicin can be increased when it is combined with Tipifarnib.Investigational
TipranavirThe serum concentration of Tipranavir can be decreased when it is combined with Rifampicin.Approved, Investigational
TizanidineThe metabolism of Tizanidine can be increased when combined with Rifampicin.Approved, Investigational
TocilizumabThe serum concentration of Rifampicin can be decreased when it is combined with Tocilizumab.Approved
TocofersolanThe metabolism of Tocofersolan can be increased when combined with Rifampicin.Approved
TocopherolThe metabolism of Tocopherol can be increased when combined with Rifampicin.Approved, Investigational
TofacitinibThe serum concentration of Tofacitinib can be decreased when it is combined with Rifampicin.Approved, Investigational
TolazamideThe serum concentration of Tolazamide can be decreased when it is combined with Rifampicin.Approved, Investigational
TolbutamideThe serum concentration of Tolbutamide can be decreased when it is combined with Rifampicin.Approved, Investigational
Tolfenamic AcidThe metabolism of Tolfenamic Acid can be increased when combined with Rifampicin.Approved, Investigational
TolterodineThe metabolism of Tolterodine can be increased when combined with Rifampicin.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be decreased when it is combined with Rifampicin.Approved
TopiramateThe serum concentration of Topiramate can be increased when it is combined with Rifampicin.Approved
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Rifampicin.Approved, Investigational
TorasemideThe metabolism of Torasemide can be increased when combined with Rifampicin.Approved
ToremifeneThe serum concentration of Toremifene can be decreased when it is combined with Rifampicin.Approved, Investigational
TrabectedinThe serum concentration of Trabectedin can be decreased when it is combined with Rifampicin.Approved, Investigational
TramadolThe serum concentration of Tramadol can be decreased when it is combined with Rifampicin.Approved, Investigational
TranilastThe metabolism of Tranilast can be increased when combined with Rifampicin.Approved, Investigational
Trastuzumab emtansineThe metabolism of Trastuzumab emtansine can be increased when combined with Rifampicin.Approved, Investigational
TrazodoneThe metabolism of Trazodone can be increased when combined with Rifampicin.Approved, Investigational
TreprostinilThe serum concentration of Treprostinil can be decreased when it is combined with Rifampicin.Approved, Investigational
TretinoinThe metabolism of Tretinoin can be increased when combined with Rifampicin.Approved, Investigational, Nutraceutical
TriamcinoloneThe metabolism of Triamcinolone can be increased when combined with Rifampicin.Approved, Vet Approved
TriamtereneThe metabolism of Triamterene can be increased when combined with Rifampicin.Approved
TriazolamThe metabolism of Triazolam can be increased when combined with Rifampicin.Approved, Investigational
TrifluoperazineThe metabolism of Trifluoperazine can be increased when combined with Rifampicin.Approved, Investigational
TriflupromazineThe serum concentration of Rifampicin can be increased when it is combined with Triflupromazine.Approved, Vet Approved
TrilostaneThe metabolism of Trilostane can be increased when combined with Rifampicin.Approved, Investigational, Vet Approved, Withdrawn
TrimebutineThe metabolism of Trimebutine can be increased when combined with Rifampicin.Approved
TrimethadioneThe metabolism of Trimethadione can be increased when combined with Rifampicin.Approved
TrimethoprimThe metabolism of Trimethoprim can be increased when combined with Rifampicin.Approved, Vet Approved
TrimipramineThe metabolism of Trimipramine can be increased when combined with Rifampicin.Approved
TroglitazoneThe serum concentration of Troglitazone can be decreased when it is combined with Rifampicin.Investigational, Withdrawn
TroleandomycinThe metabolism of Troleandomycin can be increased when combined with Rifampicin.Approved
UbidecarenoneThe serum concentration of Ubidecarenone can be increased when it is combined with Rifampicin.Approved, Investigational, Nutraceutical
UdenafilThe metabolism of Udenafil can be increased when combined with Rifampicin.Approved, Investigational
UlipristalThe serum concentration of Ulipristal can be decreased when it is combined with Rifampicin.Approved
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Rifampicin.Approved
Ursodeoxycholic acidThe risk or severity of liver damage can be increased when Ursodeoxycholic acid is combined with Rifampicin.Approved, Investigational
VadimezanThe metabolism of Vadimezan can be increased when combined with Rifampicin.Investigational
ValbenazineThe metabolism of Valbenazine can be increased when combined with Rifampicin.Approved, Investigational
ValdecoxibThe metabolism of Valdecoxib can be increased when combined with Rifampicin.Approved, Investigational, Withdrawn
ValinomycinThe serum concentration of Valinomycin can be increased when it is combined with Rifampicin.Experimental
ValsartanThe excretion of Valsartan can be decreased when combined with Rifampicin.Approved, Investigational
ValspodarThe serum concentration of Valspodar can be increased when it is combined with Rifampicin.Investigational
VandetanibThe serum concentration of Vandetanib can be decreased when it is combined with Rifampicin.Approved
VanoxerineThe metabolism of Vanoxerine can be increased when combined with Rifampicin.Investigational
VardenafilThe metabolism of Vardenafil can be increased when combined with Rifampicin.Approved
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Rifampicin.Approved
VelpatasvirThe metabolism of Velpatasvir can be increased when combined with Rifampicin.Approved, Investigational
VemurafenibThe serum concentration of Vemurafenib can be decreased when it is combined with Rifampicin.Approved
VenetoclaxThe metabolism of Venetoclax can be increased when combined with Rifampicin.Approved, Investigational
VenlafaxineThe metabolism of Venlafaxine can be increased when combined with Rifampicin.Approved
VerapamilThe metabolism of Verapamil can be increased when combined with Rifampicin.Approved
VicrivirocThe metabolism of Vicriviroc can be increased when combined with Rifampicin.Investigational
VilanterolThe metabolism of Vilanterol can be increased when combined with Rifampicin.Approved
VilazodoneThe serum concentration of Vilazodone can be decreased when it is combined with Rifampicin.Approved
VinblastineThe risk or severity of liver damage can be increased when Rifampicin is combined with Vinblastine.Approved
VincristineThe serum concentration of Vincristine can be decreased when it is combined with Rifampicin.Approved, Investigational
VindesineThe metabolism of Vindesine can be increased when combined with Rifampicin.Approved, Investigational
VinflunineThe metabolism of Vinflunine can be increased when combined with Rifampicin.Approved, Investigational
VinorelbineThe metabolism of Vinorelbine can be increased when combined with Rifampicin.Approved, Investigational
VinpocetineThe metabolism of Vinpocetine can be increased when combined with Rifampicin.Investigational
VismodegibThe metabolism of Vismodegib can be increased when combined with Rifampicin.Approved, Investigational
VoacamineThe serum concentration of Rifampicin can be increased when it is combined with Voacamine.Approved, Investigational
VorapaxarThe serum concentration of Vorapaxar can be decreased when it is combined with Rifampicin.Approved
VoriconazoleThe metabolism of Voriconazole can be increased when combined with Rifampicin.Approved, Investigational
VortioxetineThe serum concentration of Vortioxetine can be decreased when it is combined with Rifampicin.Approved, Investigational
VoxilaprevirThe metabolism of Voxilaprevir can be increased when combined with Rifampicin.Approved, Investigational
WarfarinThe metabolism of Warfarin can be increased when combined with Rifampicin.Approved
WIN 55212-2The metabolism of WIN 55212-2 can be increased when combined with Rifampicin.Experimental
XanthineThe metabolism of Xanthine can be increased when combined with Rifampicin.Experimental
YohimbineThe metabolism of Yohimbine can be increased when combined with Rifampicin.Approved, Investigational, Vet Approved
ZafirlukastThe metabolism of Zafirlukast can be increased when combined with Rifampicin.Approved, Investigational
ZalcitabineThe metabolism of Zalcitabine can be increased when combined with Rifampicin.Approved, Investigational
ZaleplonThe serum concentration of Zaleplon can be decreased when it is combined with Rifampicin.Approved, Illicit, Investigational
ZiconotideThe metabolism of Ziconotide can be increased when combined with Rifampicin.Approved
ZidovudineThe serum concentration of Zidovudine can be decreased when it is combined with Rifampicin.Approved
ZileutonThe metabolism of Zileuton can be increased when combined with Rifampicin.Approved, Investigational, Withdrawn
ZiprasidoneThe metabolism of Ziprasidone can be increased when combined with Rifampicin.Approved
ZolmitriptanThe metabolism of Zolmitriptan can be increased when combined with Rifampicin.Approved, Investigational
ZolpidemThe metabolism of Zolpidem can be increased when combined with Rifampicin.Approved
ZomepiracThe metabolism of Zomepirac can be increased when combined with Rifampicin.Withdrawn
ZonisamideThe serum concentration of Zonisamide can be decreased when it is combined with Rifampicin.Approved, Investigational
ZopicloneThe metabolism of Zopiclone can be increased when combined with Rifampicin.Approved
ZosuquidarThe serum concentration of Rifampicin can be increased when it is combined with Zosuquidar.Investigational
ZotepineThe metabolism of Zotepine can be increased when combined with Rifampicin.Approved, Investigational, Withdrawn
ZuclopenthixolThe serum concentration of Zuclopenthixol can be decreased when it is combined with Rifampicin.Approved, Investigational
Food Interactions
  • Avoid alcohol.
  • Take on empty stomach: 1 hour before or 2 hours after meals.
  • Take with a full glass of water.

References

Synthesis Reference

Klaus Jurgen, Joachim Seydel, "Combination preparations containing rifampicin and thioacetazon." U.S. Patent US5104875, issued August, 1973.

US5104875
General References
  1. Baysarowich J, Koteva K, Hughes DW, Ejim L, Griffiths E, Zhang K, Junop M, Wright GD: Rifamycin antibiotic resistance by ADP-ribosylation: Structure and diversity of Arr. Proc Natl Acad Sci U S A. 2008 Mar 25;105(12):4886-91. doi: 10.1073/pnas.0711939105. Epub 2008 Mar 18. [PubMed:18349144]
External Links
Human Metabolome Database
HMDB15179
KEGG Drug
D00211
KEGG Compound
C06688
PubChem Compound
5381226
PubChem Substance
46506170
ChemSpider
10468813
BindingDB
50370232
ChEBI
71365
ChEMBL
CHEMBL374478
Therapeutic Targets Database
DNC000965
PharmGKB
PA451250
IUPHAR
2765
Guide to Pharmacology
GtP Drug Page
HET
RFP
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
Wikipedia
Rifampin
ATC Codes
J04AB02 — RifampicinJ04AM02 — Rifampicin and isoniazidJ04AM06 — Rifampicin, pyrazinamide, ethambutol and isoniazidJ04AM05 — Rifampicin, pyrazinamide and isoniazid
AHFS Codes
  • 08:16.04 — Antituberculosis Agents
PDB Entries
1i6v / 1skx / 1ynn / 2hw2 / 3aob / 3aod / 4kmu / 5hv1 / 5kox / 5uac
show 9 more
FDA label
Download (43.3 KB)
MSDS
Download (86.7 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0CompletedTreatmentDrug Interactions / Pharmacokinetics1
0Not Yet RecruitingTreatmentRhinoscleroma1
0RecruitingTreatmentOsteomyelitis1
1Active Not RecruitingNot AvailableHealthy Volunteers1
1Active Not RecruitingOtherBiological Availability1
1Active Not RecruitingOtherLung Cancer Non-Small Cell Cancer (NSCLC)1
1Active Not RecruitingOtherOncology, Medical1
1Active Not RecruitingTreatmentMetastatic Melanoma, BRAF V600 Mutation Positive1
1CompletedNot AvailableHealthy Volunteers11
1CompletedNot AvailableHealthy Volunteers / Pharmacokinetics of Darexaban and Metabolites1
1CompletedNot AvailableHypertension,Essential1
1CompletedNot AvailableMale, Healthy Normal Subjects1
1CompletedNot AvailableMalignancies, Hematologic / Malignant Lymphomas1
1CompletedNot AvailablePharmacokinetics of YM1781
1CompletedNot AvailableTumors, Solid1
1CompletedBasic ScienceAdvanced Solid Tumors1
1CompletedBasic ScienceAlzheimer's Disease (AD)1
1CompletedBasic ScienceAtherothrombotic Diseases1
1CompletedBasic ScienceCoronary Artery Disease1
1CompletedBasic ScienceDiabetes Mellitus (DM)1
1CompletedBasic ScienceDrug Induced Constipation1
1CompletedBasic ScienceDrug Interaction Potentiation1
1CompletedBasic ScienceDrug Interactions1
1CompletedBasic ScienceDrug-Drug Interaction (DDI) / Healthy Volunteers / Pharmacokinetics of Enzalutamide1
1CompletedBasic ScienceEndometriosis1
1CompletedBasic ScienceEvaluation of Pharmacokinetics of Sativex in the Absence and Presence of a CYP2C19 Inhibitor / Evaluation of Pharmacokinetics of Sativex in the Absence and Presence of a Known Inducer of CYP3A4 / Evaluation of Pharmacokinetics of Sativex in the Absence and Presence of a Potent Inhibitor of CYP3A41
1CompletedBasic ScienceGastrointestinal Hormones1
1CompletedBasic ScienceHealthy Volunteers8
1CompletedBasic ScienceHealthy Volunteers: Asian, Non-Asian1
1CompletedBasic ScienceHealthy Volunteers / Rheumatoid Arthritis1
1CompletedBasic ScienceNASH - Nonalcoholic Steatohepatitis1
1CompletedBasic ScienceParkinson's Disease (PD)1
1CompletedBasic ScienceThrombosis1
1CompletedBasic ScienceTumors, Solid1
1CompletedDiagnosticLung Function / Sarcoidosis, Pulmonary1
1CompletedHealth Services ResearchHuman Immunodeficiency Virus (HIV)1
1CompletedOtherBiological Availability1
1CompletedOtherHealthy Volunteers2
1CompletedOtherMalignancies Multiple1
1CompletedOtherTuberculosis2
1CompletedTreatmentAdult Solid Neoplasm1
1CompletedTreatmentAdvanced Solid Tumors1
1CompletedTreatmentAdvanced Solid Tumors / Neoplasms1
1CompletedTreatmentAnaplastic Large-Cell Lymphoma / Lymphoma, Hodgkins1
1CompletedTreatmentCarcinoma NOS / Hodgkins Disease (HD) / Lymphoma, Large-Cell, Anaplastic / Neoplasms / Non-Hodgkin's Lymphoma (NHL)1
1CompletedTreatmentCystic Fibrosis (CF)2
1CompletedTreatmentDrug Interactions1
1CompletedTreatmentHCV / Hepatitis C Viral Infection / Pharmacokinetics / Rifampin / Tuberculosis1
1CompletedTreatmentHealthy Male Volunteers1
1CompletedTreatmentHealthy Participants2
1CompletedTreatmentHealthy Volunteers20
1CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections1
1CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Opioid Dependency1
1CompletedTreatmentHuman Immunodeficiency Virus (HIV) / Tuberculosis1
1CompletedTreatmentImpaired Renal Function1
1CompletedTreatmentLymphoma, Including Chronic Lymphocytic Leukemia / Tumors, Solid1
1CompletedTreatmentMalignant Lymphomas / Nonhematologic Malignancies1
1CompletedTreatmentMalignant Lymphomas / Tumors, Solid1
1CompletedTreatmentMalignant Melanoma, Neoplasms1
1CompletedTreatmentMultiple Myeloma (MM) / Non-Hodgkin's Lymphoma (NHL)1
1CompletedTreatmentNeoplasms1
1CompletedTreatmentNocturia1
1CompletedTreatmentPharmacokinetics1
1CompletedTreatmentTuberculosis6
1CompletedTreatmentTuberculosis / Tuberculosis, Pulmonary1
1CompletedTreatmentTumors1
1CompletedTreatmentType 2 Diabetes Mellitus1
1CompletedTreatmentProphylaxis of acute chemotherapy induced nausea and vomiting / Vomiting1
1Not Yet RecruitingOtherHealthy Volunteers1
1Not Yet RecruitingOtherNeoplasms, Advanced Solid1
1Not Yet RecruitingTreatmentHIV-1-infection / Tuberculosis1
1RecruitingBasic ScienceAutoimmune Diseases / Drug Drug Interactions / Fibrotic Disease1
1RecruitingBasic ScienceHealthy Volunteers1
1RecruitingOtherHealthy Volunteers1
1RecruitingTreatmentAdvanced Malignancies (Except Leukemia) / Advanced Malignancies Except Leukemia / Non-Small Cell Lung Cancer (ALK-positive) / Non-Small Cell Lung Cancer (c-Met Dependent) / Non-Small Cell Lung Cancer (ROS Marker Positive) / Non-Small Cell Lung Cancer ALK-positive / Non-Small Cell Lung Cancer c-Met Dependent / Non-Small Cell Lung Cancer ROS Marker Positive / Systemic Anaplastic Large-Cell Lymphoma1
1RecruitingTreatmentHealthy Participants1
1RecruitingTreatmentHuman Immunodeficiency Virus (HIV)1
1RecruitingTreatmentIdiopathic Infantile Hypercalcemia - Mild Form1
1RecruitingTreatmentTuberculosis1
1SuspendedTreatmentTuberculosis1
1TerminatedNot AvailableType 2 Diabetes Mellitus1
1TerminatedBasic ScienceInfection NOS1
1Unknown StatusNot AvailableAdverse Drug Interactions1
1WithdrawnBasic ScienceHealthy Volunteers1
1WithdrawnBasic ScienceNon-Hodgkin's Lymphoma (NHL)1
1WithdrawnBasic SciencePulmonary Arterial Hypertension (PAH)1
1WithdrawnTreatmentCancers1
1, 2CompletedDiagnosticHealthy Volunteers1
1, 2RecruitingTreatmentTuberculous Meningitis1
2CompletedBasic ScienceChronic Kidney Disease (CKD) / Tuberculosis1
2CompletedBasic ScienceTuberculosis1
2CompletedTreatmentCystic Fibrosis (CF)1
2CompletedTreatmentCystic Fibrosis (CF) / Methicillin-Resistant Staphylococcus Aureus (MRSA)1
2CompletedTreatmentDisseminated Sclerosis1
2CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Infection, Mycobacterium Avium-Intracellulare1
2CompletedTreatmentInfection, Mycobacterium Avium-Intracellulare1
2CompletedTreatmentOnchocerciasis1
2CompletedTreatmentSmear Positive, Pan-sensitive, Pulmonary Tuberculosis1
2CompletedTreatmentTuberculosis4
2CompletedTreatmentTuberculosis, Pulmonary4
2CompletedTreatmentTuberculous Meningitis1
2RecruitingTreatmentDrug-resistant Tuberculosis / Drug-Resistant Tuberculosis, Extremely / Tuberculosis / Tuberculosis, MDR / Tuberculosis, Multidrug Resistant / Tuberculosis, Pulmonary1
2RecruitingTreatmentGenetic Diseases / Hypercalcemia, Idiopathic, of Infancy / Hypercalciuria / Hypercalciuric Hypercalcemia / Idiopathic Infantile Hypercalcaemia - Severe Form / Idiopathic Infantile Hypercalcemia - Mild Form1
2RecruitingTreatmentSarcoidosis; Antimycobacterial Therapy1
2RecruitingTreatmentTuberculosis, Pulmonary1
2SuspendedTreatmentTuberculosis, Pulmonary1
2TerminatedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Tuberculosis1
2TerminatedTreatmentInfected Spacers / Prosthetic Joint Infections of Hip / Prosthetic Joint Infections of Knee1
2Unknown StatusTreatmentHip Prosthetic Joint Infection1
2Unknown StatusTreatmentPulmonary Tuberculosis (TB)1
2Unknown StatusTreatmentTuberculosis1
2, 3CompletedTreatmentTuberculous Meningitis1
2, 3Not Yet RecruitingTreatmentTuberculosis, Pulmonary1
2, 3Not Yet RecruitingTreatmentLate phase Tuberculosis1
3Active Not RecruitingTreatmentHuman Immunodeficiency Virus (HIV) Infections / Tuberculosis, Pulmonary1
3CompletedPreventionHuman Immunodeficiency Virus (HIV) Infections / Tuberculosis1
3CompletedTreatmentAcquired Immune Deficiency Syndrome (AIDS) / Human Immunodeficiency Virus (HIV) Infections / Tuberculosis1
3CompletedTreatmentAlzheimer's Disease (AD)1
3CompletedTreatmentAntibiotic-Associated Diarrhea / Clostridium Enterocolitis / Pseudomembranous Colitis / Pseudomembranous Enteritis / Pseudomembranous Enterocolitis1
3CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Tuberculosis1
3CompletedTreatmentHospital-acquired bacterial pneumonia / Infection Due to Resistant Bacteria / Infection of Bloodstream / Infectious Disease of Abdomen / Ventilator-Associated Pneumonia (VAP)1
3CompletedTreatmentLatent Tuberculosis Infection (LTI)2
3CompletedTreatmentReactive Arthritis / Reiter's Disease1
3CompletedTreatmentTuberculosis3
3CompletedTreatmentTuberculosis, Pulmonary1
3CompletedTreatmentTuberculosis, Pulmonary, Drug Sensitive / Tuberculosis, Pulmonary, Multi Drug-resistant1
3Not Yet RecruitingTreatmentLung Infection / Mycobacterium avium complex infection1
3RecruitingTreatmentInfective Endocarditis1
3RecruitingTreatmentTuberculosis1
3RecruitingTreatmentTuberculosis, Pulmonary1
3TerminatedTreatmentMultiple System Atrophy (MSA)1
3Unknown StatusTreatmentAlzheimer's Disease (AD)1
3Unknown StatusTreatmentDrug Safety1
3Unknown StatusTreatmentHuman Immunodeficiency Virus (HIV) Infections / Tuberculosis1
4Active Not RecruitingPreventionInfection, Human Immunodeficiency Virus I1
4Active Not RecruitingTreatmentDiabetes Mellitus (DM) / Tuberculin (Skin Test) Positive1
4CompletedBasic ScienceBlood Pressure Regulation1
4CompletedBasic ScienceGlucose Metabolism1
4CompletedBasic ScienceGlucose Tolerance1
4CompletedBasic ScienceHealthy Volunteers1
4CompletedBasic ScienceNon-Alcoholic Fatty Liver Disease (NAFLD)1
4CompletedTreatmentMRSA Infection1
4Not Yet RecruitingDiagnosticDrug Interactions / Transplantation, Kidney1
4Not Yet RecruitingTreatmentCystic Fibrosis (CF) / MRSA1
4RecruitingTreatmentAIDS With Tuberculosis1
4RecruitingTreatmentAmputations / Diabetes Mellitus (DM) / Osteomyelitis1
4RecruitingTreatmentHuman Immunodeficiency Virus (HIV) Infections1
4RecruitingTreatmentOsteoarticular Infections1
4RecruitingTreatmentTuberculosis, Pulmonary1
4RecruitingTreatmentTuberculosis, Spinal1
4Unknown StatusTreatmentHepatitis / Tuberculosis, Pulmonary1
4Unknown StatusTreatmentHuman Immunodeficiency Virus (HIV) Infections / Tuberculosis1
4Unknown StatusTreatmentInfection caused by staphylococci / Prosthesis-Related Infections1
4Unknown StatusTreatmentReinfection Pulmonary Tuberculosis1
Not AvailableActive Not RecruitingBasic ScienceVitamin D and Calcium Homeostasis1
Not AvailableCompletedNot AvailableHealthy Volunteers1
Not AvailableCompletedBasic ScienceDrug Interactions / Healthy Volunteers / Warfarin1
Not AvailableCompletedBasic ScienceHuman Immunodeficiency Virus (HIV) Infections1
Not AvailableCompletedDiagnosticCYP3A4 Induction1
Not AvailableCompletedPreventionHuman Immunodeficiency Virus (HIV) Infections / Tuberculosis1
Not AvailableCompletedSupportive CareBody Weight Changes / Motor Activities / Tuberculosis, Pulmonary1
Not AvailableCompletedTreatmentCystic Fibrosis (CF)1
Not AvailableCompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Tuberculosis4
Not AvailableCompletedTreatmentOsteoarticular Infections1
Not AvailableCompletedTreatmentTuberculosis1
Not AvailableNot Yet RecruitingBasic ScienceHealthy Volunteers1
Not AvailableNot Yet RecruitingTreatmentProsthetic Joint Infection1
Not AvailableRecruitingNot AvailableTuberculosis1
Not AvailableRecruitingOtherHealthy Volunteers1
Not AvailableRecruitingPreventionMotility Disorders / Staphylococcus Aureus1
Not AvailableRecruitingTreatmentAcquired Immune Deficiency Syndrome (AIDS) / Tuberculosis, Pulmonary1
Not AvailableRecruitingTreatmentDrug-resistant Tuberculosis / Tuberculosis / Tuberculosis, Multidrug Resistant1
Not AvailableRecruitingTreatmentMethicillin-Resistant Staphylococcus Aureus (MRSA)1
Not AvailableUnknown StatusNot AvailableTuberculosis, Pulmonary1
Not AvailableUnknown StatusTreatmentHidradenitis Suppurativa (HS)1
Not AvailableUnknown StatusTreatmentScrub Typhus1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
  • AAIPharma Inc.
  • Akorn Inc.
  • Amerisource Health Services Corp.
  • Apotheca Inc.
  • A-S Medication Solutions LLC
  • Bedford Labs
  • Belgomex Sprl
  • Ben Venue Laboratories Inc.
  • Cardinal Health
  • Ciba Geigy Ltd.
  • Comprehensive Consultant Services Inc.
  • Dept Health Central Pharmacy
  • Eon Labs
  • Gruppo Lepetit SPA
  • H.J. Harkins Co. Inc.
  • Innoviant Pharmacy Inc.
  • Lannett Co. Inc.
  • Major Pharmaceuticals
  • Mckesson Corp.
  • Medisca Inc.
  • Merrell Pharmaceuticals Inc.
  • Murfreesboro Pharmaceutical Nursing Supply
  • Novartis AG
  • Nucare Pharmaceuticals Inc.
  • PD-Rx Pharmaceuticals Inc.
  • Physicians Total Care Inc.
  • Rebel Distributors Corp.
  • Remedy Repack
  • Sanofi-Aventis Inc.
  • Spectrum Pharmaceuticals
  • Stat Rx Usa
  • Strides Arcolab Limited
  • Tya Pharmaceuticals
  • UDL Laboratories
  • Versapharm Inc.
  • West-Ward Pharmaceuticals
Dosage forms
FormRouteStrength
CapsuleOral
CapsuleOral150 mg
CapsuleOral300 mg
CapsuleOral150 mg/1
CapsuleOral300 mg/1
Capsule, coatedOral300 mg/1
Injection, powder, lyophilized, for solutionIntravenous600 mg/10mL
Injection, powder, lyophilized, for solutionIntravenous600 mg/1
TabletOral
Tablet, sugar coatedOral
Prices
Unit descriptionCostUnit
Rifadin iv 600 mg vial140.9USD vial
Rifampin iv 600 mg vial136.3USD vial
Rifampin crystals6.72USD g
Rifampin powder3.98USD g
Rifadin 300 mg capsule3.09USD capsule
Rifadin 150 mg capsule2.57USD capsule
Rifampin 300 mg capsule2.37USD capsule
Rimactane 300 mg capsule2.35USD capsule
Rifampin 150 mg capsule2.27USD capsule
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)183 °CNot Available
water solubility1400 mg/L (at 25 °C)YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP2.7Not Available
pKa1.7SANGSTER (2004)
Predicted Properties
PropertyValueSource
Water Solubility0.0413 mg/mLALOGPS
logP3.85ALOGPS
logP2.77ChemAxon
logS-4.3ALOGPS
pKa (Strongest Acidic)6.9ChemAxon
pKa (Strongest Basic)7.53ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count14ChemAxon
Hydrogen Donor Count6ChemAxon
Polar Surface Area220.15 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity225.58 m3·mol-1ChemAxon
Polarizability86.46 Å3ChemAxon
Number of Rings5ChemAxon
Bioavailability0ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.5553
Blood Brain Barrier-0.974
Caco-2 permeable-0.7123
P-glycoprotein substrateSubstrate0.9308
P-glycoprotein inhibitor IInhibitor0.8564
P-glycoprotein inhibitor IINon-inhibitor0.6049
Renal organic cation transporterNon-inhibitor0.8178
CYP450 2C9 substrateNon-substrate0.8508
CYP450 2D6 substrateNon-substrate0.9115
CYP450 3A4 substrateSubstrate0.7296
CYP450 1A2 substrateNon-inhibitor0.9045
CYP450 2C9 inhibitorNon-inhibitor0.907
CYP450 2D6 inhibitorNon-inhibitor0.9231
CYP450 2C19 inhibitorNon-inhibitor0.9025
CYP450 3A4 inhibitorNon-inhibitor0.8432
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9099
Ames testNon AMES toxic0.5803
CarcinogenicityNon-carcinogens0.8493
BiodegradationNot ready biodegradable0.9962
Rat acute toxicity2.6875 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.908
hERG inhibition (predictor II)Non-inhibitor0.5486
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as macrolactams. These are cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring. They are nitrogen analogues (the a nitrogen atom replacing the o atom of the cyclic carboxylic acid group ) of the naturally occurring macrolides.
Kingdom
Organic compounds
Super Class
Phenylpropanoids and polyketides
Class
Macrolactams
Sub Class
Not Available
Direct Parent
Macrolactams
Alternative Parents
Naphthofurans / Naphthols and derivatives / Benzofurans / Coumarans / Aryl alkyl ketones / Hydroquinones / Ketals / N-methylpiperazines / Amino acids and derivatives / Trialkylamines
show 13 more
Substituents
Macrolactam / Naphthofuran / 1-naphthol / Naphthalene / Benzofuran / Coumaran / Hydroquinone / Aryl alkyl ketone / Aryl ketone / Ketal
show 35 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
N-methylpiperazine, N-iminopiperazine, rifamycin (CHEBI:28077) / Ansamycins (C06688)

Targets

Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
Yes
Actions
Inhibitor
General Function
Ribonucleoside binding
Specific Function
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Gene Name
rpoB
Uniprot ID
P0A8V2
Uniprot Name
DNA-directed RNA polymerase subunit beta
Molecular Weight
150631.165 Da
References
  1. Villain-Guillot P, Bastide L, Gualtieri M, Leonetti JP: Progress in targeting bacterial transcription. Drug Discov Today. 2007 Mar;12(5-6):200-8. Epub 2007 Feb 5. [PubMed:17331884]
  2. White RJ, Lancini GC, Silvestri LG: Mechanism of action of rifampin on Mycobacterium smegmatis. J Bacteriol. 1971 Nov;108(2):737-41. [PubMed:4942761]
  3. Tupin A, Gualtieri M, Roquet-Baneres F, Morichaud Z, Brodolin K, Leonetti JP: Resistance to rifampicin: at the crossroads between ecological, genomic and medical concerns. Int J Antimicrob Agents. 2010 Jun;35(6):519-23. doi: 10.1016/j.ijantimicag.2009.12.017. Epub 2010 Feb 24. [PubMed:20185278]
  4. Campbell EA, Korzheva N, Mustaev A, Murakami K, Nair S, Goldfarb A, Darst SA: Structural mechanism for rifampicin inhibition of bacterial rna polymerase. Cell. 2001 Mar 23;104(6):901-12. [PubMed:11290327]
  5. Wehrli W: Rifampin: mechanisms of action and resistance. Rev Infect Dis. 1983 Jul-Aug;5 Suppl 3:S407-11. [PubMed:6356275]
Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
Yes
Actions
Inhibitor
General Function
Dna-directed rna polymerase activity
Specific Function
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Gene Name
rpoC
Uniprot ID
P0A8T7
Uniprot Name
DNA-directed RNA polymerase subunit beta'
Molecular Weight
155158.84 Da
References
  1. Villain-Guillot P, Bastide L, Gualtieri M, Leonetti JP: Progress in targeting bacterial transcription. Drug Discov Today. 2007 Mar;12(5-6):200-8. Epub 2007 Feb 5. [PubMed:17331884]
  2. White RJ, Lancini GC, Silvestri LG: Mechanism of action of rifampin on Mycobacterium smegmatis. J Bacteriol. 1971 Nov;108(2):737-41. [PubMed:4942761]
  3. Tupin A, Gualtieri M, Roquet-Baneres F, Morichaud Z, Brodolin K, Leonetti JP: Resistance to rifampicin: at the crossroads between ecological, genomic and medical concerns. Int J Antimicrob Agents. 2010 Jun;35(6):519-23. doi: 10.1016/j.ijantimicag.2009.12.017. Epub 2010 Feb 24. [PubMed:20185278]
  4. Campbell EA, Korzheva N, Mustaev A, Murakami K, Nair S, Goldfarb A, Darst SA: Structural mechanism for rifampicin inhibition of bacterial rna polymerase. Cell. 2001 Mar 23;104(6):901-12. [PubMed:11290327]
  5. Wehrli W: Rifampin: mechanisms of action and resistance. Rev Infect Dis. 1983 Jul-Aug;5 Suppl 3:S407-11. [PubMed:6356275]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Agonist
General Function
Zinc ion binding
Specific Function
Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism an...
Gene Name
NR1I2
Uniprot ID
O75469
Uniprot Name
Nuclear receptor subfamily 1 group I member 2
Molecular Weight
49761.245 Da
References
  1. Chen J, Raymond K: Roles of rifampicin in drug-drug interactions: underlying molecular mechanisms involving the nuclear pregnane X receptor. Ann Clin Microbiol Antimicrob. 2006 Feb 15;5:3. [PubMed:16480505]
  2. Cheng J, Ma X, Krausz KW, Idle JR, Gonzalez FJ: Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance acetaminophen-induced toxicity. Drug Metab Dispos. 2009 Aug;37(8):1611-21. doi: 10.1124/dmd.109.027565. Epub 2009 May 21. [PubMed:19460945]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Sodium-independent organic anion transmembrane transporter activity
Specific Function
Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostagland...
Gene Name
SLCO1B1
Uniprot ID
Q9Y6L6
Uniprot Name
Solute carrier organic anion transporter family member 1B1
Molecular Weight
76447.99 Da
References
  1. Vavricka SR, Van Montfoort J, Ha HR, Meier PJ, Fattinger K: Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver. Hepatology. 2002 Jul;36(1):164-72. [PubMed:12085361]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Sodium-independent organic anion transmembrane transporter activity
Specific Function
Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibit...
Gene Name
SLCO1A2
Uniprot ID
P46721
Uniprot Name
Solute carrier organic anion transporter family member 1A2
Molecular Weight
74144.105 Da
References
  1. Vavricka SR, Van Montfoort J, Ha HR, Meier PJ, Fattinger K: Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver. Hepatology. 2002 Jul;36(1):164-72. [PubMed:12085361]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Sodium-independent organic anion transmembrane transporter activity
Specific Function
Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotre...
Gene Name
SLCO1B3
Uniprot ID
Q9NPD5
Uniprot Name
Solute carrier organic anion transporter family member 1B3
Molecular Weight
77402.175 Da
References
  1. Vavricka SR, Van Montfoort J, Ha HR, Meier PJ, Fattinger K: Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver. Hepatology. 2002 Jul;36(1):164-72. [PubMed:12085361]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Sterol 14-demethylase activity
Specific Function
Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.
Gene Name
CYP51A1
Uniprot ID
Q16850
Uniprot Name
Lanosterol 14-alpha demethylase
Molecular Weight
56805.26 Da
References
  1. Ekins S, Mankowski DC, Hoover DJ, Lawton MP, Treadway JL, Harwood HJ Jr: Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors. Drug Metab Dispos. 2007 Mar;35(3):493-500. Epub 2006 Dec 28. [PubMed:17194716]
Details
8. Serum albumin
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Toxic substance binding
Specific Function
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloid...
Gene Name
ALB
Uniprot ID
P02768
Uniprot Name
Serum albumin
Molecular Weight
69365.94 Da
References
  1. Baneres-Roquet F, Gualtieri M, Villain-Guillot P, Pugniere M, Leonetti JP: Use of a surface plasmon resonance method to investigate antibiotic and plasma protein interactions. Antimicrob Agents Chemother. 2009 Apr;53(4):1528-31. doi: 10.1128/AAC.00971-08. Epub 2009 Jan 21. [PubMed:19164148]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Sodium-independent organic anion transmembrane transporter activity
Specific Function
Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost.
Gene Name
SLCO2B1
Uniprot ID
O94956
Uniprot Name
Solute carrier organic anion transporter family member 2B1
Molecular Weight
76709.98 Da
References
  1. Karlgren M, Vildhede A, Norinder U, Wisniewski JR, Kimoto E, Lai Y, Haglund U, Artursson P: Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. J Med Chem. 2012 May 24;55(10):4740-63. doi: 10.1021/jm300212s. Epub 2012 May 15. [PubMed:22541068]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
Inducer
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2C9
Uniprot ID
P11712
Uniprot Name
Cytochrome P450 2C9
Molecular Weight
55627.365 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014]
  2. Dixit V, Hariparsad N, Li F, Desai P, Thummel KE, Unadkat JD: Cytochrome P450 enzymes and transporters induced by anti-human immunodeficiency virus protease inhibitors in human hepatocytes: implications for predicting clinical drug interactions. Drug Metab Dispos. 2007 Oct;35(10):1853-9. Epub 2007 Jul 16. [PubMed:17639026]
  3. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
  4. Clin-Info. (2006). In Compendium of Pharmaceuticals and Specialties: The Canadian Drug Reference for Health Professionals (pp. L57). Canadian Pharmacists Association. [ISBN:1-894402-22-7]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inducer
General Function
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP1A2
Uniprot ID
P05177
Uniprot Name
Cytochrome P450 1A2
Molecular Weight
58293.76 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
Inducer
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2C8
Uniprot ID
P10632
Uniprot Name
Cytochrome P450 2C8
Molecular Weight
55824.275 Da
References
  1. Dixit V, Hariparsad N, Li F, Desai P, Thummel KE, Unadkat JD: Cytochrome P450 enzymes and transporters induced by anti-human immunodeficiency virus protease inhibitors in human hepatocytes: implications for predicting clinical drug interactions. Drug Metab Dispos. 2007 Oct;35(10):1853-9. Epub 2007 Jul 16. [PubMed:17639026]
  2. Madan A, Graham RA, Carroll KM, Mudra DR, Burton LA, Krueger LA, Downey AD, Czerwinski M, Forster J, Ribadeneira MD, Gan LS, LeCluyse EL, Zech K, Robertson P Jr, Koch P, Antonian L, Wagner G, Yu L, Parkinson A: Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes. Drug Metab Dispos. 2003 Apr;31(4):421-31. [PubMed:12642468]
  3. Glaeser H, Drescher S, Eichelbaum M, Fromm MF: Influence of rifampicin on the expression and function of human intestinal cytochrome P450 enzymes. Br J Clin Pharmacol. 2005 Feb;59(2):199-206. doi: 10.1111/j.1365-2125.2004.02265.x. [PubMed:15676042]
  4. Gerbal-Chaloin S, Pascussi JM, Pichard-Garcia L, Daujat M, Waechter F, Fabre JM, Carrere N, Maurel P: Induction of CYP2C genes in human hepatocytes in primary culture. Drug Metab Dispos. 2001 Mar;29(3):242-51. [PubMed:11181490]
  5. Rae JM, Johnson MD, Lippman ME, Flockhart DA: Rifampin is a selective, pleiotropic inducer of drug metabolism genes in human hepatocytes: studies with cDNA and oligonucleotide expression arrays. J Pharmacol Exp Ther. 2001 Dec;299(3):849-57. [PubMed:11714868]
  6. Raucy JL, Mueller L, Duan K, Allen SW, Strom S, Lasker JM: Expression and induction of CYP2C P450 enzymes in primary cultures of human hepatocytes. J Pharmacol Exp Ther. 2002 Aug;302(2):475-82. doi: 10.1124/jpet.102.033837. [PubMed:12130704]
  7. Li AP, Reith MK, Rasmussen A, Gorski JC, Hall SD, Xu L, Kaminski DL, Cheng LK: Primary human hepatocytes as a tool for the evaluation of structure-activity relationship in cytochrome P450 induction potential of xenobiotics: evaluation of rifampin, rifapentine and rifabutin. Chem Biol Interact. 1997 Nov 6;107(1-2):17-30. [PubMed:9402947]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
Inducer
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Dixit V, Hariparsad N, Li F, Desai P, Thummel KE, Unadkat JD: Cytochrome P450 enzymes and transporters induced by anti-human immunodeficiency virus protease inhibitors in human hepatocytes: implications for predicting clinical drug interactions. Drug Metab Dispos. 2007 Oct;35(10):1853-9. Epub 2007 Jul 16. [PubMed:17639026]
  2. Edwards RJ, Price RJ, Watts PS, Renwick AB, Tredger JM, Boobis AR, Lake BG: Induction of cytochrome P450 enzymes in cultured precision-cut human liver slices. Drug Metab Dispos. 2003 Mar;31(3):282-8. [PubMed:12584154]
  3. Svensson EM, Murray S, Karlsson MO, Dooley KE: Rifampicin and rifapentine significantly reduce concentrations of bedaquiline, a new anti-TB drug. J Antimicrob Chemother. 2015 Apr;70(4):1106-14. doi: 10.1093/jac/dku504. Epub 2014 Dec 21. [PubMed:25535219]
  4. Clin-Info. (2006). In Compendium of Pharmaceuticals and Specialties: The Canadian Drug Reference for Health Professionals (pp. L57). Canadian Pharmacists Association. [ISBN:1-894402-22-7]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inducer
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2B6
Uniprot ID
P20813
Uniprot Name
Cytochrome P450 2B6
Molecular Weight
56277.81 Da
References
  1. Dixit V, Hariparsad N, Li F, Desai P, Thummel KE, Unadkat JD: Cytochrome P450 enzymes and transporters induced by anti-human immunodeficiency virus protease inhibitors in human hepatocytes: implications for predicting clinical drug interactions. Drug Metab Dispos. 2007 Oct;35(10):1853-9. Epub 2007 Jul 16. [PubMed:17639026]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inducer
General Function
Steroid binding
Specific Function
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the...
Gene Name
UGT1A1
Uniprot ID
P22309
Uniprot Name
UDP-glucuronosyltransferase 1-1
Molecular Weight
59590.91 Da
References
  1. Ellis E, Wagner M, Lammert F, Nemeth A, Gumhold J, Strassburg CP, Kylander C, Katsika D, Trauner M, Einarsson C, Marschall HU: Successful treatment of severe unconjugated hyperbilirubinemia via induction of UGT1A1 by rifampicin. J Hepatol. 2006 Jan;44(1):243-5. Epub 2005 Oct 27. [PubMed:16288819]
  2. Jemnitz K, Lengyel G, Vereczkey L: In vitro induction of bilirubin conjugation in primary rat hepatocyte culture. Biochem Biophys Res Commun. 2002 Feb 15;291(1):29-33. [PubMed:11829457]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inducer
General Function
Steroid hydroxylase activity
Specific Function
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and im...
Gene Name
CYP2C19
Uniprot ID
P33261
Uniprot Name
Cytochrome P450 2C19
Molecular Weight
55930.545 Da
References
  1. Edwards RJ, Price RJ, Watts PS, Renwick AB, Tredger JM, Boobis AR, Lake BG: Induction of cytochrome P450 enzymes in cultured precision-cut human liver slices. Drug Metab Dispos. 2003 Mar;31(3):282-8. [PubMed:12584154]
  2. Clin-Info. (2006). In Compendium of Pharmaceuticals and Specialties: The Canadian Drug Reference for Health Professionals (pp. L57). Canadian Pharmacists Association. [ISBN:1-894402-22-7]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
Inhibitor
Inducer
General Function
Steroid hydroxylase activity
Specific Function
Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Const...
Gene Name
CYP2A6
Uniprot ID
P11509
Uniprot Name
Cytochrome P450 2A6
Molecular Weight
56501.005 Da
References
  1. Edwards RJ, Price RJ, Watts PS, Renwick AB, Tredger JM, Boobis AR, Lake BG: Induction of cytochrome P450 enzymes in cultured precision-cut human liver slices. Drug Metab Dispos. 2003 Mar;31(3):282-8. [PubMed:12584154]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inducer
General Function
Steroid hydroxylase activity
Specific Function
Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic ...
Gene Name
CYP2E1
Uniprot ID
P05181
Uniprot Name
Cytochrome P450 2E1
Molecular Weight
56848.42 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inducer
General Function
Monooxygenase activity
Specific Function
Exhibits low testosterone 6-beta-hydroxylase activity.
Gene Name
CYP3A43
Uniprot ID
Q9HB55
Uniprot Name
Cytochrome P450 3A43
Molecular Weight
57669.21 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inducer
General Function
Oxygen binding
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP3A5
Uniprot ID
P20815
Uniprot Name
Cytochrome P450 3A5
Molecular Weight
57108.065 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inducer
General Function
Oxygen binding
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP3A7
Uniprot ID
P24462
Uniprot Name
Cytochrome P450 3A7
Molecular Weight
57525.03 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inducer
General Function
Leukotriene-b4 20-monooxygenase activity
Specific Function
Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate, myristate and palmitate. Has little activity toward prostaglandins A1 and E1. Oxidizes arachidonic acid to 2...
Gene Name
CYP4A11
Uniprot ID
Q02928
Uniprot Name
Cytochrome P450 4A11
Molecular Weight
59347.31 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
No
Actions
Inducer
General Function
Steroid hydroxylase activity
Specific Function
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic...
Gene Name
CYP2D6
Uniprot ID
P10635
Uniprot Name
Cytochrome P450 2D6
Molecular Weight
55768.94 Da
References
  1. Agrawal A, Agarwal SK, Kaleekal T, Gupta YK: Rifampicin and anti-hypertensive drugs in chronic kidney disease: Pharmacokinetic interactions and their clinical impact. Indian J Nephrol. 2016 Sep;26(5):322-328. doi: 10.4103/0971-4065.176145. [PubMed:27795624]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
Inducer
General Function
Xenobiotic-transporting atpase activity
Specific Function
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name
ABCB1
Uniprot ID
P08183
Uniprot Name
Multidrug resistance protein 1
Molecular Weight
141477.255 Da
References
  1. Geick A, Eichelbaum M, Burk O: Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin. J Biol Chem. 2001 May 4;276(18):14581-7. Epub 2001 Jan 31. [PubMed:11297522]
  2. Schuetz EG, Beck WT, Schuetz JD: Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells. Mol Pharmacol. 1996 Feb;49(2):311-8. [PubMed:8632764]
  3. Greiner B, Eichelbaum M, Fritz P, Kreichgauer HP, von Richter O, Zundler J, Kroemer HK: The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin. J Clin Invest. 1999 Jul;104(2):147-53. [PubMed:10411543]
  4. Fardel O, Lecureur V, Loyer P, Guillouzo A: Rifampicin enhances anti-cancer drug accumulation and activity in multidrug-resistant cells. Biochem Pharmacol. 1995 May 11;49(9):1255-60. [PubMed:7763306]
  5. Collett A, Tanianis-Hughes J, Hallifax D, Warhurst G: Predicting P-glycoprotein effects on oral absorption: correlation of transport in Caco-2 with drug pharmacokinetics in wild-type and mdr1a(-/-) mice in vivo. Pharm Res. 2004 May;21(5):819-26. [PubMed:15180340]
  6. Kuypers DR, Verleden G, Naesens M, Vanrenterghem Y: Drug interaction between mycophenolate mofetil and rifampin: possible induction of uridine diphosphate-glucuronosyltransferase. Clin Pharmacol Ther. 2005 Jul;78(1):81-8. [PubMed:16003296]
  7. Gurley BJ, Barone GW, Williams DK, Carrier J, Breen P, Yates CR, Song PF, Hubbard MA, Tong Y, Cheboyina S: Effect of milk thistle (Silybum marianum) and black cohosh (Cimicifuga racemosa) supplementation on digoxin pharmacokinetics in humans. Drug Metab Dispos. 2006 Jan;34(1):69-74. Epub 2005 Oct 12. [PubMed:16221754]
  8. Chen J, Raymond K: Roles of rifampicin in drug-drug interactions: underlying molecular mechanisms involving the nuclear pregnane X receptor. Ann Clin Microbiol Antimicrob. 2006 Feb 15;5:3. [PubMed:16480505]
  9. Lamba J, Strom S, Venkataramanan R, Thummel KE, Lin YS, Liu W, Cheng C, Lamba V, Watkins PB, Schuetz E: MDR1 genotype is associated with hepatic cytochrome P450 3A4 basal and induction phenotype. Clin Pharmacol Ther. 2006 Apr;79(4):325-38. Epub 2006 Feb 20. [PubMed:16580901]
  10. Huang R, Murry DJ, Kolwankar D, Hall SD, Foster DR: Vincristine transcriptional regulation of efflux drug transporters in carcinoma cell lines. Biochem Pharmacol. 2006 Jun 14;71(12):1695-704. Epub 2006 Apr 18. [PubMed:16620787]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
Inhibitor
General Function
Sodium-independent organic anion transmembrane transporter activity
Specific Function
Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotre...
Gene Name
SLCO1B3
Uniprot ID
Q9NPD5
Uniprot Name
Solute carrier organic anion transporter family member 1B3
Molecular Weight
77402.175 Da
References
  1. Cui Y, Konig J, Leier I, Buchholz U, Keppler D: Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6. J Biol Chem. 2001 Mar 30;276(13):9626-30. Epub 2000 Dec 27. [PubMed:11134001]
  2. Vavricka SR, Van Montfoort J, Ha HR, Meier PJ, Fattinger K: Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver. Hepatology. 2002 Jul;36(1):164-72. [PubMed:12085361]
  3. Cui Y, Konig J, Keppler D: Vectorial transport by double-transfected cells expressing the human uptake transporter SLC21A8 and the apical export pump ABCC2. Mol Pharmacol. 2001 Nov;60(5):934-43. [PubMed:11641421]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Transporter activity
Specific Function
Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotre...
Gene Name
ABCC1
Uniprot ID
P33527
Uniprot Name
Multidrug resistance-associated protein 1
Molecular Weight
171589.5 Da
References
  1. Courtois A, Payen L, Vernhet L, de Vries EG, Guillouzo A, Fardel O: Inhibition of multidrug resistance-associated protein (MRP) activity by rifampicin in human multidrug-resistant lung tumor cells. Cancer Lett. 1999 May 3;139(1):97-104. [PubMed:10408915]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Sodium-independent organic anion transmembrane transporter activity
Specific Function
Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost.
Gene Name
SLCO2B1
Uniprot ID
O94956
Uniprot Name
Solute carrier organic anion transporter family member 2B1
Molecular Weight
76709.98 Da
References
  1. Vavricka SR, Van Montfoort J, Ha HR, Meier PJ, Fattinger K: Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver. Hepatology. 2002 Jul;36(1):164-72. [PubMed:12085361]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Transporter activity
Specific Function
Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.
Gene Name
ABCB11
Uniprot ID
O95342
Uniprot Name
Bile salt export pump
Molecular Weight
146405.83 Da
References
  1. Byrne JA, Strautnieks SS, Mieli-Vergani G, Higgins CF, Linton KJ, Thompson RJ: The human bile salt export pump: characterization of substrate specificity and identification of inhibitors. Gastroenterology. 2002 Nov;123(5):1649-58. [PubMed:12404239]
  2. Wang EJ, Casciano CN, Clement RP, Johnson WW: Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites. Pharm Res. 2003 Apr;20(4):537-44. [PubMed:12739759]
  3. Noe J, Hagenbuch B, Meier PJ, St-Pierre MV: Characterization of the mouse bile salt export pump overexpressed in the baculovirus system. Hepatology. 2001 May;33(5):1223-31. [PubMed:11343252]
  4. Stieger B, Fattinger K, Madon J, Kullak-Ublick GA, Meier PJ: Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver. Gastroenterology. 2000 Feb;118(2):422-30. [PubMed:10648470]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Sodium-independent organic anion transmembrane transporter activity
Specific Function
Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibit...
Gene Name
SLCO1A2
Uniprot ID
P46721
Uniprot Name
Solute carrier organic anion transporter family member 1A2
Molecular Weight
74144.105 Da
References
  1. Vavricka SR, Van Montfoort J, Ha HR, Meier PJ, Fattinger K: Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver. Hepatology. 2002 Jul;36(1):164-72. [PubMed:12085361]
  2. Fattinger K, Cattori V, Hagenbuch B, Meier PJ, Stieger B: Rifamycin SV and rifampicin exhibit differential inhibition of the hepatic rat organic anion transporting polypeptides, Oatp1 and Oatp2. Hepatology. 2000 Jul;32(1):82-6. [PubMed:10869292]
  3. Shitara Y, Sugiyama D, Kusuhara H, Kato Y, Abe T, Meier PJ, Itoh T, Sugiyama Y: Comparative inhibitory effects of different compounds on rat oatpl (slc21a1)- and Oatp2 (Slc21a5)-mediated transport. Pharm Res. 2002 Feb;19(2):147-53. [PubMed:11883641]
  4. van Montfoort JE, Stieger B, Meijer DK, Weinmann HJ, Meier PJ, Fattinger KE: Hepatic uptake of the magnetic resonance imaging contrast agent gadoxetate by the organic anion transporting polypeptide Oatp1. J Pharmacol Exp Ther. 1999 Jul;290(1):153-7. [PubMed:10381771]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Sodium-independent organic anion transmembrane transporter activity
Specific Function
Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulf...
Gene Name
SLC22A7
Uniprot ID
Q9Y694
Uniprot Name
Solute carrier family 22 member 7
Molecular Weight
60025.025 Da
References
  1. Sekine T, Cha SH, Tsuda M, Apiwattanakul N, Nakajima N, Kanai Y, Endou H: Identification of multispecific organic anion transporter 2 expressed predominantly in the liver. FEBS Lett. 1998 Jun 12;429(2):179-82. [PubMed:9650585]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Sodium-independent organic anion transmembrane transporter activity
Specific Function
Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostagland...
Gene Name
SLCO1B1
Uniprot ID
Q9Y6L6
Uniprot Name
Solute carrier organic anion transporter family member 1B1
Molecular Weight
76447.99 Da
References
  1. Cui Y, Konig J, Leier I, Buchholz U, Keppler D: Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6. J Biol Chem. 2001 Mar 30;276(13):9626-30. Epub 2000 Dec 27. [PubMed:11134001]
  2. Vavricka SR, Van Montfoort J, Ha HR, Meier PJ, Fattinger K: Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver. Hepatology. 2002 Jul;36(1):164-72. [PubMed:12085361]
  3. Tirona RG, Leake BF, Wolkoff AW, Kim RB: Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation. J Pharmacol Exp Ther. 2003 Jan;304(1):223-8. [PubMed:12490595]
  4. Sharma P, Holmes VE, Elsby R, Lambert C, Surry D: Validation of cell-based OATP1B1 assays to assess drug transport and the potential for drug-drug interaction to support regulatory submissions. Xenobiotica. 2010 Jan;40(1):24-37. doi: 10.3109/00498250903351013. [PubMed:19919292]
  5. Anderson MS, Cote J, Liu Y, Stypinski D, Auger P, Hohnstein A, Rasmussen S, Johnson-Levonas AO, Gutstein DE: Effects of Rifampin, a potent inducer of drug-metabolizing enzymes and an inhibitor of OATP1B1/3 transport, on the single dose pharmacokinetics of anacetrapib. J Clin Pharmacol. 2013 Jul;53(7):746-52. doi: 10.1002/jcph.97. Epub 2013 May 14. [PubMed:23670789]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inducer
General Function
Organic anion transmembrane transporter activity
Specific Function
Acts as a multispecific organic anion pump which can transport nucleotide analogs.
Gene Name
ABCC5
Uniprot ID
O15440
Uniprot Name
Multidrug resistance-associated protein 5
Molecular Weight
160658.8 Da
References
  1. Schrenk D, Baus PR, Ermel N, Klein C, Vorderstemann B, Kauffmann HM: Up-regulation of transporters of the MRP family by drugs and toxins. Toxicol Lett. 2001 Mar 31;120(1-3):51-7. [PubMed:11323161]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inducer
General Function
Organic anion transmembrane transporter activity
Specific Function
Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.
Gene Name
ABCC2
Uniprot ID
Q92887
Uniprot Name
Canalicular multispecific organic anion transporter 1
Molecular Weight
174205.64 Da
References
  1. Kauffmann HM, Pfannschmidt S, Zoller H, Benz A, Vorderstemann B, Webster JI, Schrenk D: Influence of redox-active compounds and PXR-activators on human MRP1 and MRP2 gene expression. Toxicology. 2002 Feb 28;171(2-3):137-46. [PubMed:11836020]
  2. Fromm MF, Kauffmann HM, Fritz P, Burk O, Kroemer HK, Warzok RW, Eichelbaum M, Siegmund W, Schrenk D: The effect of rifampin treatment on intestinal expression of human MRP transporters. Am J Pathol. 2000 Nov;157(5):1575-80. [PubMed:11073816]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inducer
General Function
Organic anion transmembrane transporter activity
Specific Function
May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocyte...
Gene Name
ABCC3
Uniprot ID
O15438
Uniprot Name
Canalicular multispecific organic anion transporter 2
Molecular Weight
169341.14 Da
References
  1. Teng S, Jekerle V, Piquette-Miller M: Induction of ABCC3 (MRP3) by pregnane X receptor activators. Drug Metab Dispos. 2003 Nov;31(11):1296-9. [PubMed:14570758]

Drug created on June 13, 2005 07:24 / Updated on August 15, 2018 09:48