Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.

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Hall N, Pain A, Berriman M, Churcher C, Harris B, Harris D, Mungall K, Bowman S, Atkin R, Baker S, Barron A, Brooks K, Buckee CO, Burrows C, Cherevach I, Chillingworth C, Chillingworth T, Christodoulou Z, Clark L, Clark R, Corton C, Cronin A, Davies R, Davis P, Dear P, Dearden F, Doggett J, Feltwell T, Goble A, Goodhead I, Gwilliam R, Hamlin N, Hance Z, Harper D, Hauser H, Hornsby T, Holroyd S, Horrocks P, Humphray S, Jagels K, James KD, Johnson D, Kerhornou A, Knights A, Konfortov B, Kyes S, Larke N, Lawson D, Lennard N, Line A, Maddison M, McLean J, Mooney P, Moule S, Murphy L, Oliver K, Ormond D, Price C, Quail MA, Rabbinowitsch E, Rajandream MA, Rutter S, Rutherford KM, Sanders M, Simmonds M, Seeger K, Sharp S, Smith R, Squares R, Squares S, Stevens K, Taylor K, Tivey A, Unwin L, Whitehead S, Woodward J, Sulston JE, Craig A, Newbold C, Barrell BG

Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.

Nature. 2002 Oct 3;419(6906):527-31.

PubMed ID
12368867 [ View in PubMed
]
Abstract

Since the sequencing of the first two chromosomes of the malaria parasite, Plasmodium falciparum, there has been a concerted effort to sequence and assemble the entire genome of this organism. Here we report the sequence of chromosomes 1, 3-9 and 13 of P. falciparum clone 3D7--these chromosomes account for approximately 55% of the total genome. We describe the methods used to map, sequence and annotate these chromosomes. By comparing our assemblies with the optical map, we indicate the completeness of the resulting sequence. During annotation, we assign Gene Ontology terms to the predicted gene products, and observe clustering of some malaria-specific terms to specific chromosomes. We identify a highly conserved sequence element found in the intergenic region of internal var genes that is not associated with their telomeric counterparts.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Dihydroorotate dehydrogenase (quinone), mitochondrialQ08210Details
Peptide deformylaseQ8I372Details
1-cys peroxiredoxinQ5MYR6Details
Translationally-controlled tumor protein homologQ8I3Z5Details
Ornithine aminotransferaseQ6LFH8Details
Heat shock protein 70Q8IB24Details
Cell division cycle protein 48 homologue,putativeC6KT34Details
Heat shock protein 90Q8IC05Details
Pyruvate kinaseC6KTA4Details
Protein disulfide-isomeraseC0H4Y6Details
Thioredoxin-related protein, putativeQ8IDH5Details
Probable ATP-dependent 6-phosphofructokinaseQ8I2Z8Details
S-adenosylmethionine synthaseQ7K6A4Details
60S ribosomal protein L4Q8I431Details
Phosphoethanolamine N-methyltransferaseQ8IDQ9Details
40S ribosomal protein S3aO97313Details
High molecular weight rhoptry protein 2C0H571Details
40S ribosomal protein S19C0H5C2Details
V-type proton ATPase catalytic subunit AQ76NM6Details
60S ribosomal protein L2Q8I3T9Details
14-3-3 proteinC0H4V6Details
Mature parasite-infected erythrocyte surface antigenQ8I492Details
Importin-7, putativeC0H4L1Details
Peptidyl-prolyl cis-trans isomeraseQ76NN7Details
DnaJ protein, putativeQ8IB72Details
Glutamate--tRNA ligaseQ8IDD3Details
T-complex protein 1 subunit etaO77323Details
Chaperone, putativeC0H546Details
40S ribosomal protein S5, putativeQ8IBN5Details
Skeleton-binding protein 1Q8I487Details
AdenosylhomocysteinaseP50250Details
Carbamoyl phosphate synthetaseQ8IEN3Details
Aspartate carbamoyltransferaseQ8IDP8Details
Parasite-infected erythrocyte surface proteinO77361Details
Coatomer alpha subunit, putativeC6KSR5Details
Proteasome subunit alpha typeQ8IBI3Details
Ubiquitin-conjugating enzyme E2Q8IDP1Details
60S ribosomal protein L24, putativeQ8IEM3Details
60S ribosomal protein L23Q8IE82Details
60S ribosomal protein L17, putativeQ8IDI5Details
Heat shock protein 110, putativeC0H5H0Details
Ubiquitin-60S ribosomal protein L40Q8ID50Details
Calcium-dependent protein kinase 4Q8IBS5Details
Nucleoside transporter 2Q8IB78Details
Anamorsin homologC0H4X5Details
Glutamine synthetase, putativeC0H551Details
Elongation factor 1-gamma, putativeQ8IDV0Details
Pyridoxal 5'-phosphate synthase subunit Pdx1C6KT50Details
Ferredoxin--NADP reductase, apicoplastC6KT68Details
Importin subunit alphaQ8IAW0Details
Phosphoribosylpyrophosphate synthetaseQ8IE67Details