Serine Protease Inhibitors

Exogenous or endogenous compounds which inhibit SERINE ENDOPEPTIDASES.
DrugDrug NameDrug Description
DB00001LepirudinA protein-based direct thrombin inhibitor used to reverse and prevent thrombus formation in heparin-induced thrombocytopenia.
DB00006BivalirudinA direct thrombin inhibitor used to treat heparin-induced thrombocytopenia and to prevent thrombosis during percutaneous coronary intervention.
DB00058Alpha-1-proteinase inhibitorA purified form of human alpha-1 proteinase inhibitor used to treat emphysema patients with associated alpha-1 proteinase inhibitor deficiency.
DB00278ArgatrobanA synthetic direct thrombin inhibitor used for the prevention and treatment of thrombosis related to heparin use.
DB01683ChymostatinNot Available
DB03127BenzamidineNot Available
DB044593,4-DichloroisocoumarinNot Available
DB04898XimelagatranFor the treatment of acute deep vein thrombosis.
DB06228RivaroxabanA factor Xa inhibitor used to treat deep vein thrombosis (DVT) and pulmonary embolism (PE). May also be used as thrombosis prophylaxis in specific situations.
DB06406IdraparinuxInvestigated for use/treatment in thrombosis, venous thromboembolism, strokes, heart disease, and atrial fibrillation.
DB06605ApixabanAn anticoagulant used for the prophylaxis of stroke and systemic embolism in nonvalvular atrial fibrillation, and deep vein thrombosis(DVT) leading to pulmonary embolism(PE), including in patients after a hip or knee replacement surgery.
DB06635OtamixabanInvestigated for use/treatment in thrombosis.
DB06692AprotininA serine protease inhibitor used to reduce the risk for perioperative blood loss and the need for blood transfusion in high-risk patients during cardiopulmonary bypass for coronary artery bypass graft surgery.
DB06695Dabigatran etexilateAn anticoagulant used for the prevention of venous thromboembolic events or stroke in patients with recent elective hip or knee replacement surgery and atrial fibrillation.
DB073474-(2-Aminoethyl)Benzenesulfonyl FluorideNot Available
DB09075EdoxabanA novel oral anticoagulant used for reducing the risk of stroke and systemic embolism (SE) in patients with nonvalvular atrial fibrillation (NVAF).
DB11598Antithrombin III humanAn alpha-2-glycoprotein used to prevent thromboembolisms in patients with hereditary antithrombin III deficiency.
DB11984LetaxabanLetaxaban has been used in trials studying the treatment and prevention of Venous Thromboembolism and Acute Coronary Syndrome.
DB12038UlinastatinUlinastatin has been investigated for the prevention of Cardiovascular Disease and Adverse Reaction to Drug.
DB12289DarexabanDarexaban has been used in trials studying the prevention and basic science of Japanese, Caucasian, Thromboembolism, Pharmacodynamics, and Pharmacokinetics, among others.
DB12598NafamostatUsed as an anticoagulant in patients with disseminative blood vessel coagulation, hemorrhagic lesions, and hemorrhagic tendencies. It prevents blood clot formation during extracorporeal circulation in patients undergoing continuous renal replacement...
DB12831GabexateNo approved indication.
DB12863SivelestatSivelestat has been used in trials studying the treatment of Acute Lung Injury and Respiratory Distress Syndrome, Adult.
DB13616MelagatranNot Annotated
DB13729CamostatNot Annotated
DB01990Cholesterol sulfateComponent of human seminal plasma & spermatozoa.
DB14726DabigatranNot Annotated
DB00569FondaparinuxAn anticoagulant used to prevent venous thromboembolism, to treat deep vein thrombosis, and to improve survival following myocardial infarction.
DB06404Human C1-esterase inhibitorA C1 inhibitor used to prevent angioedema attacks associated with hereditary angioedema.
DB11095DesirudinIndicated as prophylaxis of deep vein thrombosis for patients undergoing hip replacement surgery.
DB12364BetrixabanA Factor Xa inhibitor used for prophylaxis of venous thromboembolism in hospitalized patients.
DB07556CGS-27023Not Available
DB07278GW-813893Not Available
DrugDrug NameTargetType
DB00001LepirudinProthrombintarget
DB00006BivalirudinProthrombintarget
DB00006BivalirudinMyeloperoxidaseenzyme
DB00058Alpha-1-proteinase inhibitorNeutrophil elastasetarget
DB00278ArgatrobanProthrombintarget
DB00278ArgatrobanCytochrome P450 3A4enzyme
DB00278ArgatrobanCytochrome P450 3A5enzyme
DB00278ArgatrobanSerum albumincarrier
DB00278Argatrobanalpha1-acid glycoproteincarrier
DB01683ChymostatinPeptide amidasetarget
DB03127BenzamidineUrokinase-type plasminogen activatortarget
DB03127BenzamidineTrypsin-1target
DB03127BenzamidineCasein kinase II subunit alphatarget
DB03127BenzamidineKallikrein-6target
DB03127BenzamidineTrypsin-2target
DB03127BenzamidineTrypsin-3target
DB03127BenzamidineCopper transport protein ATOX1target
DB03127BenzamidineEnoyl-CoA delta isomerase 1, mitochondrialtarget
DB03127BenzamidineTrypsintarget
DB03127BenzamidineSuppressor of tumorigenicity 14 proteintarget
DB03127BenzamidineKallikrein-1target
DB044593,4-DichloroisocoumarinComplement factor Dtarget
DB04898XimelagatranProthrombintarget
DB04898XimelagatranCytochrome P450 2C9enzyme
DB06228RivaroxabanCoagulation factor Xtarget
DB06228RivaroxabanCytochrome P450 3A4enzyme
DB06228RivaroxabanCytochrome P450 2J2enzyme
DB06228RivaroxabanP-glycoprotein 1transporter
DB06228RivaroxabanCytochrome P450 3A5enzyme
DB06228RivaroxabanATP-binding cassette sub-family G member 2transporter
DB06406IdraparinuxCoagulation factor Xtarget
DB06605ApixabanCoagulation factor Xtarget
DB06605ApixabanCytochrome P450 3A4enzyme
DB06605ApixabanCytochrome P450 1A2enzyme
DB06605ApixabanCytochrome P450 2C8enzyme
DB06605ApixabanCytochrome P450 2C9enzyme
DB06605ApixabanCytochrome P450 2C19enzyme
DB06605ApixabanCytochrome P450 2J2enzyme
DB06605ApixabanP-glycoprotein 1transporter
DB06605ApixabanATP-binding cassette sub-family G member 2transporter
DB06605ApixabanCytochrome P450 3A5enzyme
DB06635OtamixabanCoagulation factor Xtarget
DB06692AprotininTrypsin-1target
DB06692AprotininChymotrypsinogen Btarget
DB06692AprotininPlasminogentarget
DB06692AprotininKallikrein-1target
DB06692AprotininCholinesteraseenzyme
DB06695Dabigatran etexilateProthrombintarget
DB06695Dabigatran etexilateP-glycoprotein 1transporter
DB06695Dabigatran etexilateLiver carboxylesterase 1enzyme
DB06695Dabigatran etexilateCocaine esteraseenzyme
DB06695Dabigatran etexilateUDP-glucuronosyltransferase 1-9enzyme
DB06695Dabigatran etexilateUDP-glucuronosyltransferase 2B7enzyme
DB06695Dabigatran etexilateUDP-glucuronosyltransferase 2B15enzyme
DB06695Dabigatran etexilateRibosyldihydronicotinamide dehydrogenase [quinone]enzyme
DB073474-(2-Aminoethyl)Benzenesulfonyl FluorideGlyceraldehyde-3-phosphate dehydrogenasetarget
DB073474-(2-Aminoethyl)Benzenesulfonyl FluorideV-type proton ATPase subunit B, brain isoformtarget
DB09075EdoxabanCoagulation factor Xtarget
DB09075EdoxabanP-glycoprotein 1transporter
DB11598Antithrombin III humanAntithrombin-IIItarget
DB12598NafamostatIntercellular adhesion molecule 1target
DB12598NafamostatTrypsin-1target
DB12598NafamostatKallikrein-1target
DB12598NafamostatProthrombintarget
DB12598NafamostatCoagulation factor Xtarget
DB12598NafamostatCoagulation factor XIItarget
DB12598NafamostatSolute carrier family 22 member 1transporter
DB12598NafamostatSolute carrier family 22 member 2transporter
DB12831GabexateTrypsin-1enzyme
DB12831GabexateComplement C1s subcomponentenzyme
DB12831GabexateComplement C1r subcomponentenzyme
DB12831GabexatePlasma kallikreintarget
DB12831GabexateProthrombintarget
DB12831GabexatePlasminogentarget
DB01990Cholesterol sulfateNuclear receptor ROR-alphatarget
DB00569FondaparinuxAntithrombin-IIItarget
DB00569FondaparinuxCoagulation factor Xtarget
DB06404Human C1-esterase inhibitorComplement C1r subcomponenttarget
DB06404Human C1-esterase inhibitorComplement C1s subcomponenttarget
DB06404Human C1-esterase inhibitorPlasma kallikreintarget
DB06404Human C1-esterase inhibitorCoagulation factor XIItarget
DB06404Human C1-esterase inhibitorProthrombintarget
DB06404Human C1-esterase inhibitorCoagulation factor XItarget
DB06404Human C1-esterase inhibitorTissue-type plasminogen activatortarget
DB11095DesirudinCarboxypeptidase A1enzyme
DB12364BetrixabanP-glycoprotein 1transporter
DB12364BetrixabanCoagulation factor Xtarget
DB12364BetrixabanPotassium voltage-gated channel subfamily H member 2transporter
DB12364BetrixabanProthrombinenzyme
DB07556CGS-27023Macrophage metalloelastasetarget
DB07556CGS-27023Interstitial collagenasetarget
DB07278GW-813893Prothrombintarget
DB07278GW-813893Coagulation factor Xtarget