Identification

Name
Desirudin
Accession Number
DB11095
Type
Biotech
Groups
Approved
Biologic Classification
Protein Based Therapies
Other protein based therapies
Description

Desirudin is a direct inhibitor of human thrombin. It has a protein structure that is similar to that of hirudin, the naturally occurring anticoagulant present in the peripharyngeal glands in the medicinal leech, Hirudo medicinalis. Hirudin is a single polypeptide chain of 65 amino acids residues and contains three disulfide bridges. Desirudin has a chemical formula of C287H440N80O110S6 with a molecular weight of 6963.52.

It is mainly indicated for the prevention of deep vein thrombosis in hip replacement surgery patients. Common side effects include: Bleeding gums, collection of blood under the skin, coughing up blood, deep, dark purple bruise and difficulty with breathing or swallowing.

Protein chemical formula
C287H440N80O110S6
Protein average weight
Not Available
Sequences
Not Available
Synonyms
  • 63-Desulfohirudin
  • 63-Desulfohirudin (Hirudo Medicinalis Isoform HV1)
  • 63-Desulfohirudin (recombinant)
  • Desirudin recombinant
  • Hirudin desirudin
External IDs
CGP-39393
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
IprivaskKitMarathon Pharmaceuticals2013-12-312016-08-31Us
IprivaskKitValeant Pharmaceuticals North America2013-12-31Not applicableUs
Categories
UNII
U0JZ726775
CAS number
120993-53-5

Pharmacology

Indication

Indicated as prophylaxis of deep vein thrombosis for patients undergoing hip replacement surgery.

Structured Indications
Pharmacodynamics

Desirudin results in dose-dependent prolongation of the activated partial thromboplastin time (aPTT).

Mechanism of action

Desirudin is a direct, highly selective thrombin inhibitor. Reversibly binds to the active thrombin site of free and clot-associated thrombin. Inhibits fibrin formation, activation of coagulation factors V, VII, and XIII, and thrombin-induced platelet aggregation resulting in a dose-dependent prolongation of the activated partial thromboplastin time (aPTT).

Absorption

Absorption is complete after subcutaneous administration. Time to peak in plasma is 1 to 3 hours.

Volume of distribution

0.25 L/kg.

Protein binding

Desirudin binds specifically and directly to thrombin, forming an extremely tight, non-covalent complex with an inhibitionconstant of approximately 2.6 x 10-13 M. Thus, free or protein bound desirudin immediately binds circulating thrombin.

Metabolism

Human and animal data suggest that desirudin is primarily eliminated and metabolized by the kidney. The total urinary excretion of unchanged desirudin amounts to 40 to 50% of the administered dose. Metabolites lacking one or two C-terminal amino acids constitute a minor proportion of the material recovered from urine (< 7%). There is no evidence for the presence of other metabolites. This indicates that desirudin is metabolized by stepwise degradation from the C-terminus probably catalyzed by carboxypeptidase(s) such as carboxypeptidase A.

Route of elimination

Urine (40% to 50% as unchanged drug).

Half life

~2 hours.

Clearance

1.5 to 2.7 mL/min/kg.

Toxicity

No data available.

Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
(4R)-limonene(4R)-limonene may increase the anticoagulant activities of Desirudin.Investigational
AbciximabAbciximab may increase the anticoagulant activities of Desirudin.Approved
AceclofenacAceclofenac may increase the anticoagulant activities of Desirudin.Approved, Investigational
AcemetacinThe risk or severity of bleeding can be increased when Desirudin is combined with Acemetacin.Approved, Experimental, Investigational
AcenocoumarolAcenocoumarol may increase the anticoagulant activities of Desirudin.Approved, Investigational
Acetylsalicylic acidAcetylsalicylic acid may increase the anticoagulant activities of Desirudin.Approved, Vet Approved
AdapaleneAdapalene may increase the anticoagulant activities of Desirudin.Approved
AlclofenacAlclofenac may increase the anticoagulant activities of Desirudin.Approved, Withdrawn
AllylestrenolThe therapeutic efficacy of Desirudin can be decreased when used in combination with Allylestrenol.Approved
AlminoprofenAlminoprofen may increase the anticoagulant activities of Desirudin.Experimental
AloxiprinAloxiprin may increase the anticoagulant activities of Desirudin.Experimental
AlprostadilAlprostadil may increase the anticoagulant activities of Desirudin.Approved, Investigational
AlteplaseAlteplase may increase the anticoagulant activities of Desirudin.Approved
AltrenogestThe therapeutic efficacy of Desirudin can be decreased when used in combination with Altrenogest.Vet Approved
Aminosalicylic AcidAminosalicylic Acid may increase the anticoagulant activities of Desirudin.Approved
AnagrelideAnagrelide may increase the anticoagulant activities of Desirudin.Approved
AncrodAncrod may increase the anticoagulant activities of Desirudin.Approved, Investigational
AndrographolideAndrographolide may increase the anticoagulant activities of Desirudin.Investigational
AnisodamineAnisodamine may increase the anticoagulant activities of Desirudin.Investigational
AnistreplaseAnistreplase may increase the anticoagulant activities of Desirudin.Approved
AntipyrineAntipyrine may increase the anticoagulant activities of Desirudin.Approved, Investigational
Antithrombin III humanDesirudin may increase the anticoagulant activities of Antithrombin III human.Approved
ApixabanApixaban may increase the anticoagulant activities of Desirudin.Approved
ApocyninApocynin may increase the anticoagulant activities of Desirudin.Investigational
ApremilastApremilast may increase the anticoagulant activities of Desirudin.Approved, Investigational
AprotininThe therapeutic efficacy of Desirudin can be decreased when used in combination with Aprotinin.Approved, Investigational, Withdrawn
ArdeparinArdeparin may increase the anticoagulant activities of Desirudin.Approved, Investigational, Withdrawn
ArgatrobanArgatroban may increase the anticoagulant activities of Desirudin.Approved, Investigational
AstaxanthinAstaxanthin may increase the anticoagulant activities of Desirudin.Investigational
AzapropazoneAzapropazone may increase the anticoagulant activities of Desirudin.Withdrawn
AzelastineAzelastine may increase the anticoagulant activities of Desirudin.Approved
Azficel-TThe risk or severity of adverse effects can be increased when Desirudin is combined with Azficel-T.Approved, Investigational
BalsalazideBalsalazide may increase the anticoagulant activities of Desirudin.Approved, Investigational
BatroxobinBatroxobin may increase the anticoagulant activities of Desirudin.Experimental
BecaplerminBecaplermin may increase the anticoagulant activities of Desirudin.Approved, Investigational
BemiparinBemiparin may increase the anticoagulant activities of Desirudin.Approved, Investigational
BendazacBendazac may increase the anticoagulant activities of Desirudin.Experimental
BenorilateBenorilate may increase the anticoagulant activities of Desirudin.Experimental
BenoxaprofenBenoxaprofen may increase the anticoagulant activities of Desirudin.Withdrawn
BenzydamineBenzydamine may increase the anticoagulant activities of Desirudin.Approved
BeraprostBeraprost may increase the anticoagulant activities of Desirudin.Investigational
BevoniumBevonium may increase the anticoagulant activities of Desirudin.Experimental
BivalirudinBivalirudin may increase the anticoagulant activities of Desirudin.Approved, Investigational
BrinaseBrinase may increase the anticoagulant activities of Desirudin.Experimental
BromfenacBromfenac may increase the anticoagulant activities of Desirudin.Approved
BucillamineBucillamine may increase the anticoagulant activities of Desirudin.Investigational
BufexamacBufexamac may increase the anticoagulant activities of Desirudin.Approved, Experimental
BuflomedilBuflomedil may increase the anticoagulant activities of Desirudin.Experimental
BumadizoneBumadizone may increase the anticoagulant activities of Desirudin.Experimental
ButylphthalideButylphthalide may increase the anticoagulant activities of Desirudin.Investigational
CangrelorCangrelor may increase the anticoagulant activities of Desirudin.Approved
CaplacizumabCaplacizumab may increase the anticoagulant activities of Desirudin.Investigational
Carbaspirin calciumCarbaspirin calcium may increase the anticoagulant activities of Desirudin.Experimental, Investigational
CarprofenCarprofen may increase the anticoagulant activities of Desirudin.Approved, Vet Approved, Withdrawn
CastanospermineCastanospermine may increase the anticoagulant activities of Desirudin.Experimental
CelecoxibCelecoxib may increase the anticoagulant activities of Desirudin.Approved, Investigational
CertoparinCertoparin may increase the anticoagulant activities of Desirudin.Approved, Investigational
ChloroquineChloroquine may increase the anticoagulant activities of Desirudin.Approved, Investigational, Vet Approved
ChlorotrianiseneChlorotrianisene may decrease the anticoagulant activities of Desirudin.Investigational, Withdrawn
Choline magnesium trisalicylateCholine magnesium trisalicylate may increase the anticoagulant activities of Desirudin.Approved
CilostazolCilostazol may increase the anticoagulant activities of Desirudin.Approved, Investigational
Citric AcidCitric Acid may increase the anticoagulant activities of Desirudin.Approved, Nutraceutical, Vet Approved
ClonixinClonixin may increase the anticoagulant activities of Desirudin.Approved
ClopidogrelClopidogrel may increase the anticoagulant activities of Desirudin.Approved
CloricromenCloricromen may increase the anticoagulant activities of Desirudin.Experimental
ClorindioneClorindione may increase the anticoagulant activities of Desirudin.Experimental
Collagenase clostridium histolyticumThe risk or severity of adverse effects can be increased when Desirudin is combined with Collagenase clostridium histolyticum.Approved, Investigational
Conjugated estrogensConjugated estrogens may decrease the anticoagulant activities of Desirudin.Approved
CurcuminCurcumin may increase the anticoagulant activities of Desirudin.Approved, Investigational
Dabigatran etexilateDabigatran etexilate may increase the anticoagulant activities of Desirudin.Approved
DaidzeinDaidzein may decrease the anticoagulant activities of Desirudin.Experimental
DalteparinDalteparin may increase the anticoagulant activities of Desirudin.Approved
DanaparoidDanaparoid may increase the anticoagulant activities of Desirudin.Approved, Withdrawn
DarexabanDesirudin may increase the anticoagulant activities of Darexaban.Investigational
DasatinibDasatinib may increase the anticoagulant activities of Desirudin.Approved, Investigational
DeferasiroxThe risk or severity of adverse effects can be increased when Desirudin is combined with Deferasirox.Approved, Investigational
DefibrotideDefibrotide may increase the anticoagulant activities of Desirudin.Approved, Investigational
DemegestoneThe therapeutic efficacy of Desirudin can be decreased when used in combination with Demegestone.Experimental
Deoxycholic AcidThe risk or severity of adverse effects can be increased when Desirudin is combined with Deoxycholic Acid.Approved
DersalazineDersalazine may increase the anticoagulant activities of Desirudin.Investigational
DesmoteplaseDesmoteplase may increase the anticoagulant activities of Desirudin.Investigational
DesogestrelThe therapeutic efficacy of Desirudin can be decreased when used in combination with Desogestrel.Approved
DextranDextran may increase the anticoagulant activities of Desirudin.Approved, Investigational, Vet Approved
DiclofenacDiclofenac may increase the anticoagulant activities of Desirudin.Approved, Vet Approved
DicoumarolDicoumarol may increase the anticoagulant activities of Desirudin.Approved
DienestrolDienestrol may decrease the anticoagulant activities of Desirudin.Approved, Investigational
DienogestThe therapeutic efficacy of Desirudin can be decreased when used in combination with Dienogest.Approved
DiethylstilbestrolDiethylstilbestrol may decrease the anticoagulant activities of Desirudin.Approved, Investigational
DifenpiramideDifenpiramide may increase the anticoagulant activities of Desirudin.Experimental
DiflunisalDiflunisal may increase the anticoagulant activities of Desirudin.Approved, Investigational
DiphenadioneDiphenadione may increase the anticoagulant activities of Desirudin.Experimental
DipyridamoleDipyridamole may increase the anticoagulant activities of Desirudin.Approved
DitazoleDitazole may increase the anticoagulant activities of Desirudin.Approved, Withdrawn
Drotrecogin alfaDrotrecogin alfa may increase the anticoagulant activities of Desirudin.Approved, Investigational, Withdrawn
DroxicamDroxicam may increase the anticoagulant activities of Desirudin.Withdrawn
DuvelisibDuvelisib may increase the anticoagulant activities of Desirudin.Investigational
DydrogesteroneThe therapeutic efficacy of Desirudin can be decreased when used in combination with Dydrogesterone.Approved, Investigational, Withdrawn
E-6201E-6201 may increase the anticoagulant activities of Desirudin.Investigational
Edetic AcidEdetic Acid may increase the anticoagulant activities of Desirudin.Approved, Vet Approved
EdoxabanEdoxaban may increase the anticoagulant activities of Desirudin.Approved
EnoxaparinEnoxaparin may increase the anticoagulant activities of Desirudin.Approved
EpimestrolEpimestrol may decrease the anticoagulant activities of Desirudin.Experimental
EpinastineEpinastine may increase the anticoagulant activities of Desirudin.Approved, Investigational
EpirizoleEpirizole may increase the anticoagulant activities of Desirudin.Approved
EplivanserinEplivanserin may increase the anticoagulant activities of Desirudin.Investigational
eplivanserineeplivanserine may increase the anticoagulant activities of Desirudin.Investigational
EpoprostenolEpoprostenol may increase the anticoagulant activities of Desirudin.Approved
EptifibatideEptifibatide may increase the anticoagulant activities of Desirudin.Approved, Investigational
EquolEquol may decrease the anticoagulant activities of Desirudin.Investigational
EstradiolEstradiol may decrease the anticoagulant activities of Desirudin.Approved, Investigational, Vet Approved
Estradiol acetateEstradiol acetate may decrease the anticoagulant activities of Desirudin.Approved, Investigational, Vet Approved
Estradiol cypionateEstradiol cypionate may decrease the anticoagulant activities of Desirudin.Approved, Investigational, Vet Approved
Estradiol valerateEstradiol valerate may decrease the anticoagulant activities of Desirudin.Approved, Investigational, Vet Approved
EstriolEstriol may decrease the anticoagulant activities of Desirudin.Approved, Investigational, Vet Approved
Estrogens, esterifiedEstrogens, esterified may decrease the anticoagulant activities of Desirudin.Approved
EstroneEstrone may decrease the anticoagulant activities of Desirudin.Approved
EtanerceptEtanercept may increase the anticoagulant activities of Desirudin.Approved, Investigational
EthenzamideEthenzamide may increase the anticoagulant activities of Desirudin.Experimental
Ethinyl EstradiolEthinyl Estradiol may decrease the anticoagulant activities of Desirudin.Approved
Ethyl biscoumacetateEthyl biscoumacetate may increase the anticoagulant activities of Desirudin.Withdrawn
EthynodiolThe therapeutic efficacy of Desirudin can be decreased when used in combination with Ethynodiol.Experimental
EtodolacEtodolac may increase the anticoagulant activities of Desirudin.Approved, Investigational, Vet Approved
EtofenamateEtofenamate may increase the anticoagulant activities of Desirudin.Approved, Investigational
EtonogestrelThe therapeutic efficacy of Desirudin can be decreased when used in combination with Etonogestrel.Approved, Investigational
EtoricoxibEtoricoxib may increase the anticoagulant activities of Desirudin.Approved, Investigational
Evening primrose oilEvening primrose oil may increase the anticoagulant activities of Desirudin.Approved, Investigational
ExisulindExisulind may increase the anticoagulant activities of Desirudin.Investigational
FelbinacFelbinac may increase the anticoagulant activities of Desirudin.Experimental
FenbufenFenbufen may increase the anticoagulant activities of Desirudin.Approved
FenoprofenFenoprofen may increase the anticoagulant activities of Desirudin.Approved
FentiazacFentiazac may increase the anticoagulant activities of Desirudin.Experimental
FeprazoneFeprazone may increase the anticoagulant activities of Desirudin.Experimental
Ferulic acidFerulic acid may increase the anticoagulant activities of Desirudin.Experimental
FibrinolysinFibrinolysin may increase the anticoagulant activities of Desirudin.Investigational
FloctafenineFloctafenine may increase the anticoagulant activities of Desirudin.Approved, Withdrawn
FluindioneDesirudin may increase the anticoagulant activities of Fluindione.Approved, Investigational
FlunixinFlunixin may increase the anticoagulant activities of Desirudin.Vet Approved
FlunoxaprofenFlunoxaprofen may increase the anticoagulant activities of Desirudin.Experimental
FlurbiprofenFlurbiprofen may increase the anticoagulant activities of Desirudin.Approved, Investigational
FondaparinuxDesirudin may increase the anticoagulant activities of Fondaparinux.Approved, Investigational
Fondaparinux sodiumFondaparinux sodium may increase the anticoagulant activities of Desirudin.Approved, Investigational
GabexateDesirudin may increase the anticoagulant activities of Gabexate.Investigational
GenisteinGenistein may decrease the anticoagulant activities of Desirudin.Investigational
GestodeneThe therapeutic efficacy of Desirudin can be decreased when used in combination with Gestodene.Approved, Investigational
GestonoroneThe therapeutic efficacy of Desirudin can be decreased when used in combination with Gestonorone.Experimental
GestrinoneThe therapeutic efficacy of Desirudin can be decreased when used in combination with Gestrinone.Approved
GuacetisalGuacetisal may increase the anticoagulant activities of Desirudin.Experimental
HeminHemin may increase the anticoagulant activities of Desirudin.Approved, Investigational
Hemoglobin crosfumarilHemoglobin crosfumaril may increase the anticoagulant activities of Desirudin.Experimental
HeparinHeparin may increase the anticoagulant activities of Desirudin.Approved, Investigational
HexestrolHexestrol may decrease the anticoagulant activities of Desirudin.Withdrawn
HigenamineHigenamine may increase the anticoagulant activities of Desirudin.Investigational
Hydroxyprogesterone caproateThe therapeutic efficacy of Desirudin can be decreased when used in combination with Hydroxyprogesterone caproate.Approved, Investigational
HydroxytyrosolHydroxytyrosol may increase the anticoagulant activities of Desirudin.Investigational
Ibritumomab tiuxetanThe risk or severity of adverse effects can be increased when Desirudin is combined with Ibritumomab tiuxetan.Approved, Investigational
IbrutinibThe risk or severity of adverse effects can be increased when Ibrutinib is combined with Desirudin.Approved
IbudilastIbudilast may increase the anticoagulant activities of Desirudin.Approved, Investigational
IbuprofenIbuprofen may increase the anticoagulant activities of Desirudin.Approved
IbuproxamIbuproxam may increase the anticoagulant activities of Desirudin.Withdrawn
IcatibantIcatibant may increase the anticoagulant activities of Desirudin.Approved, Investigational
Icosapent ethylIcosapent ethyl may increase the anticoagulant activities of Desirudin.Approved, Investigational, Nutraceutical
IdraparinuxIdraparinux may increase the anticoagulant activities of Desirudin.Investigational
IfenprodilIfenprodil may increase the anticoagulant activities of Desirudin.Approved, Investigational, Withdrawn
IfetrobanIfetroban may increase the anticoagulant activities of Desirudin.Investigational
IloprostIloprost may increase the anticoagulant activities of Desirudin.Approved, Investigational
Imidazole salicylateImidazole salicylate may increase the anticoagulant activities of Desirudin.Experimental
IndobufenIndobufen may increase the anticoagulant activities of Desirudin.Investigational
IndomethacinIndomethacin may increase the anticoagulant activities of Desirudin.Approved, Investigational
IndoprofenIndoprofen may increase the anticoagulant activities of Desirudin.Withdrawn
IsoxicamIsoxicam may increase the anticoagulant activities of Desirudin.Withdrawn
KebuzoneKebuzone may increase the anticoagulant activities of Desirudin.Experimental
KetanserinKetanserin may increase the anticoagulant activities of Desirudin.Investigational
KetoprofenKetoprofen may increase the anticoagulant activities of Desirudin.Approved, Vet Approved
KetorolacKetorolac may increase the anticoagulant activities of Desirudin.Approved
LeflunomideLeflunomide may increase the anticoagulant activities of Desirudin.Approved, Investigational
LepirudinLepirudin may increase the anticoagulant activities of Desirudin.Approved
LetaxabanDesirudin may increase the anticoagulant activities of Letaxaban.Investigational
LevonorgestrelThe therapeutic efficacy of Desirudin can be decreased when used in combination with Levonorgestrel.Approved, Investigational
LimaprostThe risk or severity of adverse effects can be increased when Limaprost is combined with Desirudin.Approved, Investigational
LinsidomineLinsidomine may increase the anticoagulant activities of Desirudin.Experimental
LisofyllineLisofylline may increase the anticoagulant activities of Desirudin.Investigational
LonazolacLonazolac may increase the anticoagulant activities of Desirudin.Experimental
LornoxicamLornoxicam may increase the anticoagulant activities of Desirudin.Approved, Investigational
LoxoprofenLoxoprofen may increase the anticoagulant activities of Desirudin.Approved, Investigational
LumiracoxibLumiracoxib may increase the anticoagulant activities of Desirudin.Approved, Investigational
Magnesium salicylateMagnesium salicylate may increase the anticoagulant activities of Desirudin.Approved
MasoprocolMasoprocol may increase the anticoagulant activities of Desirudin.Approved, Investigational
Meclofenamic acidMeclofenamic acid may increase the anticoagulant activities of Desirudin.Approved, Vet Approved
MedrogestoneThe therapeutic efficacy of Desirudin can be decreased when used in combination with Medrogestone.Approved
Medroxyprogesterone acetateThe therapeutic efficacy of Desirudin can be decreased when used in combination with Medroxyprogesterone acetate.Approved, Investigational
Mefenamic acidMefenamic acid may increase the anticoagulant activities of Desirudin.Approved
Megestrol acetateThe therapeutic efficacy of Desirudin can be decreased when used in combination with Megestrol acetate.Approved, Investigational, Vet Approved
MelagatranDesirudin may increase the anticoagulant activities of Melagatran.Experimental
MeloxicamMeloxicam may increase the anticoagulant activities of Desirudin.Approved, Vet Approved
MesalazineMesalazine may increase the anticoagulant activities of Desirudin.Approved
MestranolMestranol may decrease the anticoagulant activities of Desirudin.Approved
MetamizoleMetamizole may increase the anticoagulant activities of Desirudin.Approved, Investigational, Withdrawn
MethallenestrilMethallenestril may decrease the anticoagulant activities of Desirudin.Experimental
Methyl salicylateMethyl salicylate may increase the anticoagulant activities of Desirudin.Approved, Vet Approved
MethylestrenoloneThe therapeutic efficacy of Desirudin can be decreased when used in combination with Methylestrenolone.Experimental
MilrinoneMilrinone may increase the anticoagulant activities of Desirudin.Approved
MizoribineMizoribine may increase the anticoagulant activities of Desirudin.Investigational
MofebutazoneMofebutazone may increase the anticoagulant activities of Desirudin.Experimental
MoxestrolMoxestrol may decrease the anticoagulant activities of Desirudin.Experimental
Mycophenolate mofetilMycophenolate mofetil may increase the anticoagulant activities of Desirudin.Approved, Investigational
Mycophenolic acidMycophenolic acid may increase the anticoagulant activities of Desirudin.Approved
NabumetoneNabumetone may increase the anticoagulant activities of Desirudin.Approved
NadroparinNadroparin may increase the anticoagulant activities of Desirudin.Approved, Investigational
NafamostatNafamostat may increase the anticoagulant activities of Desirudin.Approved, Investigational
NaftifineNaftifine may increase the anticoagulant activities of Desirudin.Approved
NaftopidilNaftopidil may increase the anticoagulant activities of Desirudin.Investigational
NaproxenNaproxen may increase the anticoagulant activities of Desirudin.Approved, Vet Approved
NepafenacNepafenac may increase the anticoagulant activities of Desirudin.Approved, Investigational
NifenazoneNifenazone may increase the anticoagulant activities of Desirudin.Experimental
Niflumic AcidNiflumic Acid may increase the anticoagulant activities of Desirudin.Approved
NimesulideNimesulide may increase the anticoagulant activities of Desirudin.Approved, Investigational, Withdrawn
NintedanibThe risk or severity of adverse effects can be increased when Desirudin is combined with Nintedanib.Approved
NitroaspirinNitroaspirin may increase the anticoagulant activities of Desirudin.Investigational
NomegestrolThe therapeutic efficacy of Desirudin can be decreased when used in combination with Nomegestrol.Approved
NorethisteroneThe therapeutic efficacy of Desirudin can be decreased when used in combination with Norethisterone.Approved
NorgestrienoneThe therapeutic efficacy of Desirudin can be decreased when used in combination with Norgestrienone.Experimental
ObinutuzumabThe risk or severity of adverse effects can be increased when Desirudin is combined with Obinutuzumab.Approved, Investigational
OlopatadineOlopatadine may increase the anticoagulant activities of Desirudin.Approved
OlsalazineOlsalazine may increase the anticoagulant activities of Desirudin.Approved
Omacetaxine mepesuccinateThe risk or severity of bleeding can be increased when Desirudin is combined with Omacetaxine mepesuccinate.Approved, Investigational
Omega-3 fatty acidsOmega-3 fatty acids may increase the anticoagulant activities of Desirudin.Approved, Nutraceutical
Omega-3-carboxylic acidsThe therapeutic efficacy of Desirudin can be increased when used in combination with Omega-3-carboxylic acids.Approved, Investigational
OrgoteinOrgotein may increase the anticoagulant activities of Desirudin.Vet Approved
OtamixabanOtamixaban may increase the anticoagulant activities of Desirudin.Investigational
OxaprozinOxaprozin may increase the anticoagulant activities of Desirudin.Approved
OxyphenbutazoneOxyphenbutazone may increase the anticoagulant activities of Desirudin.Approved, Withdrawn
OzagrelOzagrel may increase the anticoagulant activities of Desirudin.Investigational
ParecoxibParecoxib may increase the anticoagulant activities of Desirudin.Approved
ParnaparinParnaparin may increase the anticoagulant activities of Desirudin.Approved, Investigational
ParthenolideParthenolide may increase the anticoagulant activities of Desirudin.Approved, Investigational
Pentaerythritol TetranitratePentaerythritol Tetranitrate may increase the anticoagulant activities of Desirudin.Approved
Pentosan PolysulfatePentosan Polysulfate may increase the anticoagulant activities of Desirudin.Approved
PentoxifyllinePentoxifylline may increase the anticoagulant activities of Desirudin.Approved, Investigational
PhenindionePhenindione may increase the anticoagulant activities of Desirudin.Approved, Investigational
PhenprocoumonPhenprocoumon may increase the anticoagulant activities of Desirudin.Approved, Investigational
Phenyl aminosalicylatePhenyl aminosalicylate may increase the anticoagulant activities of Desirudin.Approved
PhenylbutazonePhenylbutazone may increase the anticoagulant activities of Desirudin.Approved, Vet Approved
PicotamidePicotamide may increase the anticoagulant activities of Desirudin.Experimental
PimecrolimusPimecrolimus may increase the anticoagulant activities of Desirudin.Approved, Investigational
PirfenidonePirfenidone may increase the anticoagulant activities of Desirudin.Approved, Investigational
PiroxicamPiroxicam may increase the anticoagulant activities of Desirudin.Approved, Investigational
PirprofenPirprofen may increase the anticoagulant activities of Desirudin.Experimental
Polyestradiol phosphatePolyestradiol phosphate may decrease the anticoagulant activities of Desirudin.Approved
PranoprofenPranoprofen may increase the anticoagulant activities of Desirudin.Experimental, Investigational
PrasugrelPrasugrel may increase the anticoagulant activities of Desirudin.Approved
ProgesteroneThe therapeutic efficacy of Desirudin can be decreased when used in combination with Progesterone.Approved, Vet Approved
ProglumetacinProglumetacin may increase the anticoagulant activities of Desirudin.Experimental
PromegestoneThe therapeutic efficacy of Desirudin can be decreased when used in combination with Promegestone.Experimental
PromestrienePromestriene may decrease the anticoagulant activities of Desirudin.Investigational
PropacetamolPropacetamol may increase the anticoagulant activities of Desirudin.Approved, Investigational
PropyphenazonePropyphenazone may increase the anticoagulant activities of Desirudin.Experimental
ProquazoneProquazone may increase the anticoagulant activities of Desirudin.Experimental
Protein CDesirudin may increase the anticoagulant activities of Protein C.Approved
Protein S humanDesirudin may increase the anticoagulant activities of Protein S human.Approved
ProtocatechualdehydeDesirudin may increase the anticoagulant activities of Protocatechualdehyde.Approved
PTC299PTC299 may increase the anticoagulant activities of Desirudin.Investigational
QuinestrolQuinestrol may decrease the anticoagulant activities of Desirudin.Approved
RamatrobanRamatroban may increase the anticoagulant activities of Desirudin.Investigational
RelcovaptanRelcovaptan may increase the anticoagulant activities of Desirudin.Investigational
ResveratrolResveratrol may increase the anticoagulant activities of Desirudin.Approved, Experimental, Investigational
ReteplaseReteplase may increase the anticoagulant activities of Desirudin.Approved, Investigational
ReviparinReviparin may increase the anticoagulant activities of Desirudin.Approved, Investigational
RidogrelRidogrel may increase the anticoagulant activities of Desirudin.Approved
RivaroxabanDesirudin may increase the anticoagulant activities of Rivaroxaban.Approved
RofecoxibRofecoxib may increase the anticoagulant activities of Desirudin.Approved, Investigational, Withdrawn
RosiglitazoneRosiglitazone may increase the anticoagulant activities of Desirudin.Approved, Investigational
SalicylamideSalicylamide may increase the anticoagulant activities of Desirudin.Approved
Salicylic acidSalicylic acid may increase the anticoagulant activities of Desirudin.Approved, Investigational, Vet Approved
SalsalateSalsalate may increase the anticoagulant activities of Desirudin.Approved
SarpogrelateSarpogrelate may increase the anticoagulant activities of Desirudin.Investigational
SaruplaseSaruplase may increase the anticoagulant activities of Desirudin.Experimental
SecoisolariciresinolSecoisolariciresinol may decrease the anticoagulant activities of Desirudin.Investigational
SelexipagSelexipag may increase the anticoagulant activities of Desirudin.Approved
SemapimodSemapimod may increase the anticoagulant activities of Desirudin.Investigational
SeratrodastSeratrodast may increase the anticoagulant activities of Desirudin.Approved
SerrapeptaseSerrapeptase may increase the anticoagulant activities of Desirudin.Investigational
SevofluraneSevoflurane may increase the anticoagulant activities of Desirudin.Approved, Vet Approved
SRT501SRT501 may increase the anticoagulant activities of Desirudin.Investigational
StreptokinaseStreptokinase may increase the anticoagulant activities of Desirudin.Approved, Investigational
SugammadexSugammadex may increase the anticoagulant activities of Desirudin.Approved
SulfasalazineSulfasalazine may increase the anticoagulant activities of Desirudin.Approved
SulindacSulindac may increase the anticoagulant activities of Desirudin.Approved, Investigational
SulodexideSulodexide may increase the anticoagulant activities of Desirudin.Approved, Investigational
SuprofenSuprofen may increase the anticoagulant activities of Desirudin.Approved, Withdrawn
SuxibuzoneSuxibuzone may increase the anticoagulant activities of Desirudin.Experimental
Synthetic Conjugated Estrogens, ASynthetic Conjugated Estrogens, A may decrease the anticoagulant activities of Desirudin.Approved
Synthetic Conjugated Estrogens, BSynthetic Conjugated Estrogens, B may decrease the anticoagulant activities of Desirudin.Approved
TarenflurbilTarenflurbil may increase the anticoagulant activities of Desirudin.Investigational
TenecteplaseTenecteplase may increase the anticoagulant activities of Desirudin.Approved
TenidapTenidap may increase the anticoagulant activities of Desirudin.Experimental
TenoxicamTenoxicam may increase the anticoagulant activities of Desirudin.Approved
TepoxalinTepoxalin may increase the anticoagulant activities of Desirudin.Vet Approved
TeriflunomideTeriflunomide may increase the anticoagulant activities of Desirudin.Approved
TesmilifeneTesmilifene may increase the anticoagulant activities of Desirudin.Investigational
Testosterone cypionateThe therapeutic efficacy of Desirudin can be increased when used in combination with Testosterone cypionate.Approved
Testosterone enanthateThe therapeutic efficacy of Desirudin can be increased when used in combination with Testosterone enanthate.Approved
Testosterone undecanoateThe therapeutic efficacy of Desirudin can be increased when used in combination with Testosterone undecanoate.Approved, Investigational
Tiaprofenic acidTiaprofenic acid may increase the anticoagulant activities of Desirudin.Approved
TiboloneTibolone may increase the anticoagulant activities of Desirudin.Approved, Investigational
TicagrelorTicagrelor may increase the anticoagulant activities of Desirudin.Approved
TiclopidineTiclopidine may increase the anticoagulant activities of Desirudin.Approved
TinoridineTinoridine may increase the anticoagulant activities of Desirudin.Investigational
TinzaparinTinzaparin may increase the anticoagulant activities of Desirudin.Approved
TioclomarolTioclomarol may increase the anticoagulant activities of Desirudin.Experimental
TipranavirTipranavir may increase the anticoagulant activities of Desirudin.Approved, Investigational
TirofibanTirofiban may increase the anticoagulant activities of Desirudin.Approved
Tolfenamic AcidTolfenamic Acid may increase the anticoagulant activities of Desirudin.Approved, Investigational
TolmetinTolmetin may increase the anticoagulant activities of Desirudin.Approved
TositumomabThe risk or severity of adverse effects can be increased when Desirudin is combined with Tositumomab.Approved, Investigational
TranilastTranilast may increase the anticoagulant activities of Desirudin.Approved, Investigational
TrapidilTrapidil may increase the anticoagulant activities of Desirudin.Approved
TreprostinilTreprostinil may increase the anticoagulant activities of Desirudin.Approved, Investigational
TribenosideTribenoside may increase the anticoagulant activities of Desirudin.Experimental
TriflusalTriflusal may increase the anticoagulant activities of Desirudin.Approved, Investigational
TriptolideTriptolide may increase the anticoagulant activities of Desirudin.Investigational
Trolamine salicylateTrolamine salicylate may increase the anticoagulant activities of Desirudin.Approved
TroxerutinDesirudin may increase the anticoagulant activities of Troxerutin.Investigational
UrokinaseUrokinase may increase the anticoagulant activities of Desirudin.Approved, Investigational, Withdrawn
ValdecoxibValdecoxib may increase the anticoagulant activities of Desirudin.Approved, Investigational, Withdrawn
Vitamin EVitamin E may increase the anticoagulant activities of Desirudin.Approved, Nutraceutical, Vet Approved
VorapaxarThe risk or severity of adverse effects can be increased when Vorapaxar is combined with Desirudin.Approved
WarfarinWarfarin may increase the anticoagulant activities of Desirudin.Approved
XimelagatranXimelagatran may increase the anticoagulant activities of Desirudin.Approved, Investigational, Withdrawn
ZaltoprofenZaltoprofen may increase the anticoagulant activities of Desirudin.Approved, Investigational
ZeranolZeranol may decrease the anticoagulant activities of Desirudin.Vet Approved
ZileutonZileuton may increase the anticoagulant activities of Desirudin.Approved, Investigational, Withdrawn
ZomepiracZomepirac may increase the anticoagulant activities of Desirudin.Withdrawn
Food Interactions
Not Available

References

General References
  1. Monograph [Link]
  2. FDA label [Link]
External Links
PubChem Substance
347911114
Wikipedia
Desirudin
ATC Codes
B01AE01 — Desirudin

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2, 3CompletedPreventionDeep Venous Thrombosis1
4CompletedTreatmentThrombosis1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
Kit
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available

Taxonomy

Description
Not Available
Kingdom
Organic Compounds
Super Class
Organic Acids
Class
Carboxylic Acids and Derivatives
Sub Class
Amino Acids, Peptides, and Analogues
Direct Parent
Peptides
Alternative Parents
Not Available
Substituents
Not Available
Molecular Framework
Not Available
External Descriptors
Not Available

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Zinc ion binding
Specific Function
Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.
Gene Name
CPA1
Uniprot ID
P15085
Uniprot Name
Carboxypeptidase A1
Molecular Weight
47139.86 Da

Drug created on December 03, 2015 09:51 / Updated on May 02, 2018 00:02