Antithrombins

Name
Antithrombins
Accession Number
DBCAT000012
Description

Endogenous factors and drugs that directly inhibit the action of THROMBIN, usually by blocking its enzymatic activity. They are distinguished from INDIRECT THROMBIN INHIBITORS, such as HEPARIN, which act by enhancing the inhibitory effects of antithrombins.

ATC Classification
Drugs
DrugDrug Description
LepirudinA protein-based direct thrombin inhibitor used to reverse and prevent thrombus formation in heparin-induced thrombocytopenia.
BivalirudinA direct thrombin inhibitor used to treat heparin-induced thrombocytopenia and to prevent thrombosis during percutaneous coronary intervention.
ArgatrobanA synthetic direct thrombin inhibitor used for the prevention and treatment of thrombosis related to heparin use.
XimelagatranFor the treatment of acute deep vein thrombosis.
Dabigatran etexilateAn anticoagulant used for the prevention of venous thromboembolic events or stroke in patients with recent elective hip or knee replacement surgery and atrial fibrillation.
MelagatranNot Annotated
Antithrombin III humanAn alpha-2-glycoprotein used to prevent thromboembolisms in patients with hereditary antithrombin III deficiency.
RivaroxabanA factor Xa inhibitor used to treat deep vein thrombosis (DVT) and pulmonary embolism (PE). May also be used as thrombosis prophylaxis in specific situations.
IdraparinuxInvestigated for use/treatment in thrombosis, venous thromboembolism, strokes, heart disease, and atrial fibrillation.
ApixabanAn anticoagulant used for the prophylaxis of stroke and systemic embolism in nonvalvular atrial fibrillation, and deep vein thrombosis(DVT) leading to pulmonary embolism(PE), including in patients after a hip or knee replacement surgery.
OtamixabanInvestigated for use/treatment in thrombosis.
EdoxabanA novel oral anticoagulant used for reducing the risk of stroke and systemic embolism (SE) in patients with nonvalvular atrial fibrillation (NVAF).
LetaxabanLetaxaban has been used in trials studying the treatment and prevention of Venous Thromboembolism and Acute Coronary Syndrome.
DarexabanDarexaban has been used in trials studying the prevention and basic science of Japanese, Caucasian, Thromboembolism, Pharmacodynamics, and Pharmacokinetics, among others.
DesirudinIndicated as prophylaxis of deep vein thrombosis for patients undergoing hip replacement surgery.
DabigatranNot Annotated
FondaparinuxAn anticoagulant used to prevent venous thromboembolism, to treat deep vein thrombosis, and to improve survival following myocardial infarction.
BetrixabanA Factor Xa inhibitor used for prophylaxis of venous thromboembolism in hospitalized patients.
GW-813893Not Available
Drugs & Drug Targets
DrugTargetType
LepirudinProthrombintarget
BivalirudinProthrombintarget
BivalirudinMyeloperoxidaseenzyme
ArgatrobanProthrombintarget
ArgatrobanCytochrome P450 3A4enzyme
ArgatrobanCytochrome P450 3A5enzyme
ArgatrobanSerum albumincarrier
Argatrobanalpha1-acid glycoproteincarrier
XimelagatranProthrombintarget
XimelagatranCytochrome P450 2C9enzyme
Dabigatran etexilateProthrombintarget
Dabigatran etexilateP-glycoprotein 1transporter
Dabigatran etexilateLiver carboxylesterase 1enzyme
Dabigatran etexilateCocaine esteraseenzyme
Dabigatran etexilateUDP-glucuronosyltransferase 1-9enzyme
Dabigatran etexilateUDP-glucuronosyltransferase 2B7enzyme
Dabigatran etexilateUDP-glucuronosyltransferase 2B15enzyme
Dabigatran etexilateRibosyldihydronicotinamide dehydrogenase [quinone]enzyme
Antithrombin III humanAntithrombin-IIItarget
RivaroxabanCoagulation factor Xtarget
RivaroxabanCytochrome P450 3A4enzyme
RivaroxabanCytochrome P450 2J2enzyme
RivaroxabanP-glycoprotein 1transporter
RivaroxabanCytochrome P450 3A5enzyme
RivaroxabanATP-binding cassette sub-family G member 2transporter
IdraparinuxCoagulation factor Xtarget
ApixabanCoagulation factor Xtarget
ApixabanCytochrome P450 3A4enzyme
ApixabanCytochrome P450 1A2enzyme
ApixabanCytochrome P450 2C8enzyme
ApixabanCytochrome P450 2C9enzyme
ApixabanCytochrome P450 2C19enzyme
ApixabanCytochrome P450 2J2enzyme
ApixabanP-glycoprotein 1transporter
ApixabanATP-binding cassette sub-family G member 2transporter
ApixabanCytochrome P450 3A5enzyme
OtamixabanCoagulation factor Xtarget
EdoxabanCoagulation factor Xtarget
EdoxabanP-glycoprotein 1transporter
DesirudinCarboxypeptidase A1enzyme
FondaparinuxAntithrombin-IIItarget
FondaparinuxCoagulation factor Xtarget
BetrixabanP-glycoprotein 1transporter
BetrixabanCoagulation factor Xtarget
BetrixabanPotassium voltage-gated channel subfamily H member 2transporter
BetrixabanProthrombinenzyme
GW-813893Prothrombintarget
GW-813893Coagulation factor Xtarget