Peptides, Cyclic

Peptides whose amino and carboxy ends are linked together with a peptide bond forming a circular chain. Some of them are ANTI-INFECTIVE AGENTS. Some of them are biosynthesized non-ribosomally (PEPTIDE BIOSYNTHESIS, NON-RIBOSOMAL).
DrugDrug NameDrug Description
DB00027Gramicidin DA bactericidal antibiotic used in the treatment of dermatological and ophthalmic infections.
DB00080DaptomycinA cyclic lipopeptide antibiotic used to treat complicated skin infections and bacteremia due to Staphylococcus aureus.
DB00091CyclosporineA steroid-sparing immunosuppressant used in organ and bone marrow transplants as well as inflammatory conditions such as ulcerative colitis, rheumatoid arthritis, and atopic dermatitis.
DB00104OctreotideA peptide drug used to treat acromegaly as well as diarrhea associated with metastatic carcinoid tumors and vasoactive intestinal peptide secreting tumors.
DB00314CapreomycinAn aminoglycoside antibiotic used as an adjunct drug in tuberculosis.
DB00362AnidulafunginAn antifungal used in the treatment of several types of candida infections.
DB00520CaspofunginAn echinocandin used to treat a variety of fungal infections.
DB00626BacitracinA cyclic polypeptide antibiotic used to prevent wound infections, treat pneumonia and empyema in infants, and to treat skin and eye infections.
DB00803ColistinA polymyxin antibiotic used to treat bacterial infections caused by susceptible Gram negative bacteria.
DB00970DactinomycinAn actinomycin used to treat a wide variety of cancers.
DB01111ColistimethateAn antibiotic indicated for treatment of infections caused by susceptible strains of certain gram-negative bacilli. It is particularly useful for targeting sensitive strains of Pseudomonas aeruginosa.
DB01141MicafunginAn antifungal agent used for the treatment of candidemia, acute disseminated candidiasis, and certain other invasive Candida infections, and for the prophylaxis of Candida infections during stem cell transplantation.
DB01369QuinupristinAn antibiotic agent used in the treatment of serious vancomycin-resistant Enterococcus faecium bacteremia as well as complicated skin and skin structure infections.
DB01669Virginiamycin M1For the treatment of bacterial infections.
DB01764DalfopristinAn antibiotic used with quinupristin to treat severe or life-threatening infections of vancomycin-resistant Enterococcus faecium (VREF), and skin infections caused by methicillin susceptible staphylococcus aureus or streptococcus pyogenes.
DB03436GallichromeNot Available
DB04805Virginiamycin S1One of the components of virginiamycin, a cyclic polypeptide antibiotic complex from streptomyces virginiae, s. Loidensis, s. Mitakaensis, s. Pristina-spiralis, s. Ostreogriseus, and others. It is used to treat infections...
DB04952RamoplaninFor the treatment of bacterial infections.
DB04977PlitidepsinIntended for the treatment of various forms of cancer.
DB05158PM02734Investigated for use/treatment in cancer/tumors (unspecified) and solid tumors.
DB06176RomidepsinA histone deacetylase (HDAC) inhibitor used to treat cutaneous and peripheral T-cell lymphoma.
DB06827ViomycinViomycin is an essential component in the drug cocktail currently used to fight infections of Mycobacterium tuberculosis.
DB08993EnviomycinCyclic basic peptide related to viomycin. It is isolated from an induced mutant of Streptomyces griseoverticillatus var. tuberacticus and acts as an antitubercular agent with less ototoxicity than tuberactinomycin.
DB11403EmodepsideEmodepside is an anthelmintic drug that is effective against a number of gastrointestinal nematodes, is licensed for use in cats and belongs to the class of drugs known as the...
DB11467ThiostreptonThiostrepton is a natural cyclic oligopeptide antibiotic, derived from several strains of streptomycetes including Streptomyces azureus and Streptomyces laurentii. Thiostrepton is a natural product of the ribosomally synthesized and post-translationally...
DB11476VirginiamycinVirginiamycin is a streptogramin antibiotic similar to pristinamycin and quinupristin/dalfopristin. It is a combination of pristinamycin IIA and virginiamycin S1. Virginiamycin is used in the fuel ethanol industry to prevent...
DB11869ValspodarValspodar has been used in trials studying the treatment of Cancer, Sarcoma, Leukemia, Lymphoma, and Breast Cancer, among others.
DB12139AlisporivirAlisporivir has been used in trials studying the treatment of Hepatitis C and Chronic Hepatitis C.
DB12451SCY-635SCY-635 has been investigated for the treatment of Chronic Hepatitis C and Hepatitis C Infection.
DB12602PentetreotidePentetreotide has been used in trials studying the diagnostic of cushing syndrome.
DB12730Dolastatin 10Dolastatin 10 has been used in trials studying the treatment of Sarcoma, Leukemia, Lymphoma, Liver Cancer, and Kidney Cancer, among others.
DB130689-(N-methyl-L-isoleucine)-cyclosporin A9-(N-methyl-L-isoleucine)-cyclosporin A (NIM811) has been used in trials studying the treatment of Chronic Hepatitis C Genotype-1 Relapse.
DB13503TyrothricinA topical antibiotic with broad spectrum activity against Gram positive bacteria and some fungal infections.
DB13704PristinamycinNot Annotated
DB13985Lutetium Lu 177 dotatateA radiolabeled somatostatin analog used to treat somatostatin receptor positive gastroenteropancreatic neuroendocrine tumors.
DB14057ValinomycinA cyclododecadepsipeptide ionophore antibiotic produced by Streptomyces fulvissimus and related to the enniatins. It is composed of 3 moles each of L-valine, D-alpha-hydroxyisovaleric acid, D-valine, and L-lactic acid linked alternately...
DB14058BasifunginBasifungin, also known as aureuobacidin A, is a phosphorylceramide synthase inhibitor , .
DB11693VoclosporinVoclosporin is a novel cyclosporine analog and immunosuppressive compound currently being investigated for the treatment of psoriasis and for the prevention of organ rejection in kidney transplant patients. All studies...
DB00781Polymyxin BA polymyxin antibiotic used to treat a wide variety of infections in the body.
DB00063EptifibatideA peptide-based antagonist for glycoprotein IIb/IIIa used in the medical management of myocardial infarction and as an adjunct to percutaneous coronary intervention.
DB08965FusafungineFusafungine is an antibiotic from Fusarium lateririum, and is used for the treatment of respiratory infections.
DB13925Dotatate gallium Ga-68Dotatate gallium 68 is one of the most prominent radiopharmaceuticals used in imaging with positron emission tomography. It binds to the somatostatin-2 receptor which is usually overexpressed in many neuroendocrine...
DrugDrug NameTargetType
DB00027Gramicidin DP-glycoprotein 1transporter
DB00080DaptomycinBacterial outer membranetarget
DB00091CyclosporineCalcium signal-modulating cyclophilin ligandtarget
DB00091CyclosporinePeptidyl-prolyl cis-trans isomerase Atarget
DB00091CyclosporineCalcineurin subunit B type 2target
DB00091CyclosporineCytochrome P450 3A5enzyme
DB00091CyclosporineCytochrome P450 3A4enzyme
DB00091CyclosporineCytochrome P450 3A7enzyme
DB00091CyclosporineP-glycoprotein 1transporter
DB00091CyclosporineCanalicular multispecific organic anion transporter 2transporter
DB00091CyclosporineBile salt export pumptransporter
DB00091CyclosporineSolute carrier organic anion transporter family member 1A2transporter
DB00091CyclosporineIleal sodium/bile acid cotransportertransporter
DB00091CyclosporineSodium/bile acid cotransportertransporter
DB00091CyclosporineSolute carrier family 22 member 6transporter
DB00091CyclosporineMultidrug resistance-associated protein 7transporter
DB00091CyclosporineCanalicular multispecific organic anion transporter 1transporter
DB00091CyclosporineATP-binding cassette sub-family G member 2transporter
DB00091CyclosporineSolute carrier organic anion transporter family member 1B1transporter
DB00091CyclosporineCytochrome P450 2C19enzyme
DB00091CyclosporineCytochrome P450 2C9enzyme
DB00091CyclosporineCytochrome P450 2D6enzyme
DB00091CyclosporinePeptidyl-prolyl cis-trans isomerase F, mitochondrialtarget
DB00091CyclosporineSolute carrier organic anion transporter family member 1B3transporter
DB00104OctreotideSomatostatin receptor type 1target
DB00104OctreotideSomatostatin receptor type 5target
DB00104OctreotideSomatostatin receptor type 2target
DB00104OctreotideMyeloperoxidaseenzyme
DB00104OctreotideCytochrome P450 3A4enzyme
DB00314Capreomycin16S/23S rRNA (cytidine-2'-O)-methyltransferase TlyAtarget
DB00362Anidulafungin1,3-beta-glucan synthase component FKS1target
DB00520CaspofunginSolute carrier family 22 member 1transporter
DB00520CaspofunginP-glycoprotein 1transporter
DB00520CaspofunginSolute carrier family 22 member 6transporter
DB00520CaspofunginSolute carrier organic anion transporter family member 1B1transporter
DB00520CaspofunginSolute carrier organic anion transporter family member 1B3transporter
DB00520CaspofunginCytochrome P450 3A4enzyme
DB00520Caspofungin1,3-beta-glucan synthase component FKS1target
DB00626BacitracinAlpha-2-macroglobulintarget
DB00626BacitracinInsulin-degrading enzymetarget
DB00626BacitracinC55-isoprenyl pyrophosphatetarget
DB00626BacitracinBacitracin transport ATP-binding protein BcrAtransporter
DB00626BacitracinBacitracin transport permease protein BCRBtransporter
DB00626BacitracinBacitracin transport permease protein BcrCtransporter
DB00803ColistinBacterial outer membranetarget
DB00970DactinomycinDNAtarget
DB00970DactinomycinSolute carrier family 22 member 5transporter
DB00970DactinomycinP-glycoprotein 1transporter
DB00970DactinomycinMultidrug resistance-associated protein 6transporter
DB00970DactinomycinMultidrug resistance-associated protein 1transporter
DB00970DactinomycinATP-binding cassette sub-family G member 2transporter
DB00970DactinomycinDNA topoisomerase 2target
DB01111ColistimethateBacterial outer membranetarget
DB01141MicafunginArylsulfatase Aenzyme
DB01141MicafunginCatechol O-methyltransferaseenzyme
DB01141Micafungin1,3-beta-glucan synthase component FKS1target
DB01369Quinupristin23S ribosomal RNAtarget
DB01369Quinupristin50S ribosomal protein L10target
DB01369Quinupristin50S ribosomal protein L22target
DB01369QuinupristinCytochrome P450 3A4enzyme
DB01669Virginiamycin M1Streptogramin A acetyltransferasetarget
DB01764DalfopristinStreptogramin A acetyltransferasetarget
DB01764DalfopristinCytochrome P450 3A4enzyme
DB03436GallichromeIron(3+)-hydroxamate-binding protein FhuDtarget
DB04805Virginiamycin S160S ribosomal protein L37target
DB04977PlitidepsinCytochrome P450 3A4enzyme
DB04977PlitidepsinCytochrome P450 2A6enzyme
DB04977PlitidepsinCytochrome P450 2E1enzyme
DB04977PlitidepsinCytochrome P450 4A11enzyme
DB06176RomidepsinCytochrome P450 3A4enzyme
DB06176RomidepsinCytochrome P450 3A5enzyme
DB06176RomidepsinP-glycoprotein 1transporter
DB06176RomidepsinSolute carrier organic anion transporter family member 1B3transporter
DB06176RomidepsinCytochrome P450 1A1enzyme
DB06176RomidepsinCytochrome P450 2B6enzyme
DB06176RomidepsinCytochrome P450 2C19enzyme
DB06176RomidepsinHistone deacetylase 1target
DB06176RomidepsinHistone deacetylase 2target
DB06176RomidepsinHistone deacetylase 4target
DB06176RomidepsinHistone deacetylase 6target
DB06176RomidepsinMultidrug resistance-associated protein 1target
DB06827Viomycin16S/23S rRNA (cytidine-2'-O)-methyltransferase TlyAtarget
DB11869ValspodarSolute carrier organic anion transporter family member 1B1transporter
DB11869ValspodarSolute carrier organic anion transporter family member 1B3transporter
DB13503TyrothricinAcetylcholinesterasetarget
DB13503TyrothricinBeta-galactosidasetarget
DB13503TyrothricinPhospholipid membranetarget
DB13985Lutetium Lu 177 dotatateSomatostatin receptor type 2target
DB13985Lutetium Lu 177 dotatateSomatostatin receptor type 1target
DB13985Lutetium Lu 177 dotatateSomatostatin receptor type 3target
DB13985Lutetium Lu 177 dotatateSomatostatin receptor type 4target
DB13985Lutetium Lu 177 dotatateSomatostatin receptor type 5target
DB14057ValinomycinBile salt export pumptransporter
DB14058BasifunginInositol phosphorylceramide synthasetarget
DB11693VoclosporinCalcineurin subunit B type 1target
DB11693VoclosporinCalcineurin subunit B type 2target
DB00781Polymyxin BBacterial outer membranetarget
DB00781Polymyxin BSolute carrier family 15 member 2transporter
DB00063EptifibatideIntegrin beta-3target
DB13925Dotatate gallium Ga-68Somatostatin receptor type 2target