Peptides, Cyclic

Peptides whose amino and carboxy ends are linked together with a peptide bond forming a circular chain. Some of them are ANTI-INFECTIVE AGENTS. Some of them are biosynthesized non-ribosomally (PEPTIDE BIOSYNTHESIS, NON-RIBOSOMAL).
DrugDrug NameDrug Indication
DB00027Gramicidin DFor treatment of skin lesions, surface wounds and eye infections.
DB00080DaptomycinFor the treatment of complicated skin and skin structure infections caused by susceptible strains of Gram-positive microorganisms.
DB00091CyclosporineFor treatment of transplant (kidney, liver, and heart) rejection, rheumatoid arthritis, severe psoriasis.
DB00104OctreotideFor treatment of acromegaly and reduction of side effects from cancer chemotherapy
DB00314CapreomycinUsed in the treatment of tuberculosis in combination with other drugs.
DB00362AnidulafunginFor use in the treatment of the following fungal infections: Candidemia and other forms of Candida infections (intra-abdominal abscess, and peritonitis), Aspergillus infections, and esophageal candidiasis. Also considered an alternative treatment for oropharyngeal canaidiasis.
DB00520CaspofunginFor the treatment of esophageal candidiasis and invasive aspergillosis in patients who are refractory to or intolerant of other therapies.
DB00626BacitracinFor the treatment of infants with pneumonia and empyema caused by staphylococci shown to be susceptible to the drug. Also used in ointment form for topical treatment of a variety of localized skin and eye infections, as well as for the prevention of wound infections. Used against gram positive bacteria. Bacitracin is also used as an inhibitor of proteases and other enzymes. However, specific activity of bactracin's inhibition of protein disulfide isomerase has been called into question.
DB00781Polymyxin B SulfateFor treatment of infections of the urinary tract, meninges, and blood stream, caused by susceptible strains of Pseudomonas aeruginosa.
DB00803ColistinFor the treatment of acute or chronic infections due to sensitive strains of certain gram-negative bacilli, particularly Pseudomonas aeruginosa.
DB00970DactinomycinFor the treatment of Wilms' tumor, childhood rhabdomyosarcoma, Ewing's sarcoma and metastatic, nonseminomatous testicular cancer as part of a combination chemotherapy and/or multi-modality treatment regimen
DB01111ColistimethateFor the treatment of acute or chronic infections due to sensitive strains of certain gram-negative bacilli, particularly _Pseudomonas aeruginosa_.
DB01141MicafunginFor use in the treatment of candidemia, acute disseminated candidiasis, and certain other invasive Candida infections, as well as esophageal candidiasis, and prophylaxis of Candida infections in patients undergoing hematopoietic stem cell transplantation. Micafungin is also used as an alternative for the treatment of oropharyngeal candidiases and has been used with some success as primary or salvage therapy, alone or in combination with other antifungals, for the treatment of invasive aspergillosis.
DB01369QuinupristinFor the treatment of bacterial infections (usually in combination with dalfopristin).
DB01669Virginiamycin M1For the treatment of bacterial infections.
DB01764DalfopristinFor the treatment of bacterial infections (usually in combination with quinupristin).
DB03436GallichromeNot Available
DB04805Virginiamycin S1Not Available
DB04952RamoplaninFor the treatment of bacterial infections.
DB04977PlitidepsinIntended for the treatment of various forms of cancer.
DB05158PM02734Investigated for use/treatment in cancer/tumors (unspecified) and solid tumors.
DB06176RomidepsinFor the treatment of cutaneous T-cell lymphoma (CTCL) or/and peripheral T-cell lymphoma (PTCL) in patients who have received at least one prior systemic therapy. These indications are based on response rate. Clinical benefit such as improvement in overall survival has not been demonstrated.
DB06827ViomycinViomycin is an essential component in the drug cocktail currently used to fight infections of Mycobacterium tuberculosis.
DB08993EnviomycinNot Available
DB11403EmodepsideNot Available
DB11869ValspodarNot Available
DB12139AlisporivirNot Available
DB12451SCY-635Not Available
DB12602PentetreotideNot Available
DB12730Dolastatin 10Not Available
DB130689-(N-methyl-L-isoleucine)-cyclosporin ANot Available
DB13503TyrothricinTyrothricin is used as an over the counter topical antibiotic.
DB13704PristinamycinNot Available
DB13985Lutetium Lu 177 dotatateIndicated for the treatment of somatostatin receptor-positive gastroenteropancreatic neuroendocrine tumors (GEP-NETs), including foregut, midgut, and hindgut neuroendocrine tumors in adults [FDA Label].
DB14057ValinomycinNot Available
DB14058BasifunginNot Available
DB11693VoclosporinNot Available
DrugDrug NameTargetType
DB00027Gramicidin DMultidrug resistance protein 1transporter
DB00080DaptomycinBacterial outer membranetarget
DB00080DaptomycinLipoteichoic acid synthesistarget
DB00091CyclosporineCytochrome P450 3A5enzyme
DB00091CyclosporineCytochrome P450 3A4enzyme
DB00091CyclosporineCytochrome P450 3A7enzyme
DB00091CyclosporineCytochrome P450 2C19enzyme
DB00091CyclosporineCytochrome P450 2C8enzyme
DB00091CyclosporineCytochrome P450 2C9enzyme
DB00091CyclosporineCytochrome P450 2D6enzyme
DB00091CyclosporineCalcium signal-modulating cyclophilin ligandtarget
DB00091CyclosporinePeptidyl-prolyl cis-trans isomerase Atarget
DB00091CyclosporineCalcineurin subunit B type 2target
DB00091CyclosporinePeptidyl-prolyl cis-trans isomerase F, mitochondrialtarget
DB00091CyclosporineMultidrug resistance protein 1transporter
DB00091CyclosporineCanalicular multispecific organic anion transporter 2transporter
DB00091CyclosporineBile salt export pumptransporter
DB00091CyclosporineMultidrug resistance-associated protein 1transporter
DB00091CyclosporineSolute carrier organic anion transporter family member 1A2transporter
DB00091CyclosporineIleal sodium/bile acid cotransportertransporter
DB00091CyclosporineSodium/bile acid cotransportertransporter
DB00091CyclosporineSolute carrier family 22 member 6transporter
DB00091CyclosporineMultidrug resistance-associated protein 7transporter
DB00091CyclosporineCanalicular multispecific organic anion transporter 1transporter
DB00091CyclosporineATP-binding cassette sub-family G member 2transporter
DB00091CyclosporineSolute carrier organic anion transporter family member 1B1transporter
DB00091CyclosporineSolute carrier organic anion transporter family member 1B3transporter
DB00104OctreotideMyeloperoxidaseenzyme
DB00104OctreotideCytochrome P450 3A4enzyme
DB00104OctreotideSomatostatin receptor type 1target
DB00104OctreotideSomatostatin receptor type 5target
DB00104OctreotideSomatostatin receptor type 2target
DB00314Capreomycin70S ribosometarget
DB00362Anidulafungin1,3-beta-glucan synthase component FKS1target
DB00520CaspofunginCytochrome P450 3A4enzyme
DB00520Caspofungin1,3-beta-glucan synthase component FKS1target
DB00520CaspofunginSolute carrier family 22 member 1transporter
DB00520CaspofunginMultidrug resistance protein 1transporter
DB00520CaspofunginSolute carrier family 22 member 6transporter
DB00520CaspofunginSolute carrier organic anion transporter family member 1B1transporter
DB00520CaspofunginSolute carrier organic anion transporter family member 1B3transporter
DB00626BacitracinAlpha-2-macroglobulintarget
DB00626BacitracinInsulin-degrading enzymetarget
DB00626BacitracinC55-isoprenyl pyrophosphatetarget
DB00781Polymyxin B SulfateBacterial outer membranetarget
DB00803ColistinBacterial outer membranetarget
DB00970DactinomycinDNAtarget
DB00970DactinomycinDNA topoisomerase 2target
DB00970DactinomycinSolute carrier family 22 member 5transporter
DB00970DactinomycinMultidrug resistance protein 1transporter
DB00970DactinomycinMultidrug resistance-associated protein 6transporter
DB00970DactinomycinMultidrug resistance-associated protein 1transporter
DB00970DactinomycinATP-binding cassette sub-family G member 2transporter
DB01111ColistimethateBacterial outer membranetarget
DB01141MicafunginArylsulfatase Aenzyme
DB01141MicafunginCatechol O-methyltransferaseenzyme
DB01141Micafungin1,3-beta-glucan synthase component FKS1target
DB01369QuinupristinCytochrome P450 3A4enzyme
DB01369Quinupristin23S rRNAtarget
DB01369Quinupristin50S ribosomal protein L10target
DB01369Quinupristin50S ribosomal protein L22target
DB01669Virginiamycin M1Streptogramin A acetyltransferasetarget
DB01764DalfopristinCytochrome P450 3A4enzyme
DB01764DalfopristinStreptogramin A acetyltransferasetarget
DB03436GallichromeIron(3+)-hydroxamate-binding protein FhuDtarget
DB04805Virginiamycin S160S ribosomal protein L37target
DB04977PlitidepsinCytochrome P450 3A4enzyme
DB04977PlitidepsinCytochrome P450 2A6enzyme
DB04977PlitidepsinCytochrome P450 2E1enzyme
DB04977PlitidepsinCytochrome P450 4A11enzyme
DB06176RomidepsinCytochrome P450 3A4enzyme
DB06176RomidepsinCytochrome P450 3A5enzyme
DB06176RomidepsinCytochrome P450 1A1enzyme
DB06176RomidepsinCytochrome P450 2B6enzyme
DB06176RomidepsinCytochrome P450 2C19enzyme
DB06176RomidepsinHistone deacetylase 1target
DB06176RomidepsinHistone deacetylase 2target
DB06176RomidepsinHistone deacetylase 4target
DB06176RomidepsinHistone deacetylase 6target
DB06176RomidepsinMultidrug resistance-associated protein 1target
DB06176RomidepsinMultidrug resistance protein 1transporter
DB06176RomidepsinSolute carrier organic anion transporter family member 1B3transporter
DB06827Viomycin70S ribosometarget
DB11869ValspodarSolute carrier organic anion transporter family member 1B1transporter
DB11869ValspodarSolute carrier organic anion transporter family member 1B3transporter
DB13503TyrothricinAcetylcholinesterasetarget
DB13503TyrothricinBeta-galactosidasetarget
DB13503TyrothricinPhospholipid membranetarget
DB13985Lutetium Lu 177 dotatateSomatostatin receptor type 2target
DB13985Lutetium Lu 177 dotatateSomatostatin receptor type 1target
DB13985Lutetium Lu 177 dotatateSomatostatin receptor type 3target
DB13985Lutetium Lu 177 dotatateSomatostatin receptor type 4target
DB13985Lutetium Lu 177 dotatateSomatostatin receptor type 5target
DB14057ValinomycinBile salt export pumptransporter
DB14058BasifunginInositol phosphorylceramide synthasetarget
DB11693VoclosporinCalcineurin subunit B type 1target
DB11693VoclosporinCalcineurin subunit B type 2target