|DB00027||Gramicidin D||For treatment of skin lesions, surface wounds and eye infections.|
|DB00080||Daptomycin||For the treatment of complicated skin and skin structure infections caused by susceptible strains of Gram-positive microorganisms.|
|DB00091||Ciclosporin||Cyclosporine is officially approved for different conditions listed below:
* Prophylaxis of organ rejection in kidney, liver, and heart allogeneic transplants. For this indication, it can be used concomitantly with azathioprine and corticosteroids.
* Treatment of patients with severe active, rheumatoid arthritis when the patient no longer responds to methotrexate.
* Concomitantly with methotrexate for the treatment of patients with severe active rheumatoid arthritis when patients do not respond to methotrexate treatment alone.
* Treatment of adult nonimmunocompromised patients with severe, recalcitrant, plaque psoriasis that have failed to respond to at least one systemic therapy or when systemic therapies are not tolerated or contraindicated.[FDA label]
* Its ophthalmic solution is indicated to increase tear production in patients with keratoconjunctivitis sicca in patients from 4 years old.[L5158]
* Prevention of graft rejection following bone marrow transplantation and in the treatment of graft-versus-host disease (GVHD).
* Treatment of steroid dependent and steroid-resistant nephrotic syndrome due to glomerular diseases such as minimal change nephropathy, focal and segmental glomerulosclerosis or membranous glomerulonephritis in adults and children.[F3091]
Away from all this approved and reviewed indications, cyclosporine is commonly used on dermatology for the treatment of various inflammatory skin conditions such as atopic dermatitis, blistering disorders, and connective tissue diseases.[A174085]|
|DB00104||Octreotide||For treatment of acromegaly and reduction of side effects from cancer chemotherapy|
|DB00314||Capreomycin||Used in the treatment of tuberculosis in combination with other drugs.|
|DB00362||Anidulafungin||For use in the treatment of the following fungal infections: Candidemia and other forms of Candida infections (intra-abdominal abscess, and peritonitis), Aspergillus infections, and esophageal candidiasis. Also considered an alternative treatment for oropharyngeal canaidiasis.|
|DB00520||Caspofungin||For the treatment of esophageal candidiasis and invasive aspergillosis in patients who are refractory to or intolerant of other therapies.|
|DB00626||Bacitracin||For the treatment of infants with pneumonia and empyema caused by staphylococci shown to be susceptible to the drug. Also used in ointment form for topical treatment of a variety of localized skin and eye infections, as well as for the prevention of wound infections. Used against gram positive bacteria. Bacitracin is also used as an inhibitor of proteases and other enzymes.
However, specific activity of bactracin's inhibition of protein disulfide isomerase has been called into question. |
|DB00781||Polymyxin B sulfate||For treatment of infections of the urinary tract, meninges, and blood stream, caused by susceptible strains of Pseudomonas aeruginosa.|
|DB00803||Colistin||For the treatment of acute or chronic infections due to sensitive strains of certain gram-negative bacilli, particularly Pseudomonas aeruginosa.|
|DB00970||Dactinomycin||For the treatment of Wilms' tumor, childhood rhabdomyosarcoma, Ewing's sarcoma and metastatic, nonseminomatous testicular cancer as part of a combination chemotherapy and/or multi-modality treatment regimen|
|DB01111||Colistimethate||For the treatment of acute or chronic infections due to sensitive strains of certain gram-negative bacilli, particularly _Pseudomonas aeruginosa_.|
|DB01141||Micafungin||For use in the treatment of candidemia, acute disseminated candidiasis, and certain other invasive Candida infections, as well as esophageal candidiasis, and prophylaxis of Candida infections in patients undergoing hematopoietic stem cell transplantation. Micafungin is also used as an alternative for the treatment of oropharyngeal candidiases and has been used with some success as primary or salvage therapy, alone or in combination with other antifungals, for the treatment of invasive aspergillosis.|
|DB01369||Quinupristin||For the treatment of bacterial infections (usually in combination with dalfopristin).|
|DB01669||Virginiamycin M1||For the treatment of bacterial infections.|
|DB01764||Dalfopristin||For the treatment of bacterial infections (usually in combination with quinupristin).|
|DB04805||Virginiamycin S1||Not Available|
|DB04952||Ramoplanin||For the treatment of bacterial infections.|
|DB04977||Plitidepsin||Intended for the treatment of various forms of cancer.|
|DB05158||PM02734||Investigated for use/treatment in cancer/tumors (unspecified) and solid tumors.|
|DB06176||Romidepsin||For the treatment of cutaneous T-cell lymphoma (CTCL) or/and peripheral T-cell lymphoma (PTCL) in patients who have received at least one prior systemic therapy. These indications are based on response rate. Clinical benefit such as improvement in overall survival has not been demonstrated. |
|DB06827||Viomycin||Viomycin is an essential component in the drug cocktail currently used to fight infections of Mycobacterium tuberculosis.|
|DB12730||Dolastatin 10||Not Available|
|DB13068||9-(N-methyl-L-isoleucine)-cyclosporin A||Not Available|
|DB13503||Tyrothricin||Tyrothricin is used as an over the counter topical antibiotic.|
|DB13985||Lutetium Lu 177 dotatate||Indicated for the treatment of somatostatin receptor-positive gastroenteropancreatic neuroendocrine tumors (GEP-NETs), including foregut, midgut, and hindgut neuroendocrine tumors in adults [FDA Label].|