Vasoconstrictor Agents

Drugs used to cause constriction of the blood vessels.
DrugDrug NameDrug Indication
DB00935OxymetazolineFor treatment of nasal congestion and redness associated with minor irritations of the eye
DB00388PhenylephrinePhenylephrine is mainly used to treat nasal congestion, but may also be useful in treating hypotension and shock, hypotension during spinal anaesthesia, prolongation of spinal anaesthesia, paroxysmal supraventricular tachycardia, symptomatic relief of external or internal hemorrhoids, and to increase blood pressure as an aid in the diagnosis of heart murmurs.
DB00668EpinephrineEpinephrine injection is indicated in the emergency treatment of allergic reactions (Type I) including anaphylaxis to stinging insects (e.g., order Hymenoptera, which include bees, wasps, hornets, yellow jackets and fire ants) and biting insects (e.g., triatoma, mosquitos), allergen immunotherapy, foods, drugs, diagnostic testing substances (e.g., radiocontrast media) and other allergens, as well as idiopathic anaphylaxis or exercise-induced anaphylaxis. Injectable epinephrine is intended for immediate/urgent administration in patients, who are found to be at increased risk for anaphylaxis, including individuals with a history of anaphylaxis. Selection of the appropriate dosage strength is determined according to body weight [FDA label]. Epinephrine's cardiac effects may be of use in restoring cardiac rhythm in cardiac arrest due to various causes but is not used in cardiac failure or in hemorrhagic, traumatic, or cardiogenic shock [F1247]. Epinephrine is used as a hemostatic agent. It is also used in treating mucosal congestion of hay fever, rhinitis, and acute sinusitis; to relieve bronchial asthmatic paroxysms; in syncope due to complete heart block or carotid sinus hypersensitivity; for symptomatic relief of serum sickness, urticaria, angioneurotic edema; for resuscitation in cardiac arrest following anesthetic accidents; in simple (open angle) glaucoma; for relaxation of uterine musculature and to inhibit uterine contractions. Epinephrine injection can be utilized to prolong the action of local anesthetics [F1247]. In addition to the above, epinephrine is used as an over the counter (OTC) agent for the intermittent symptoms of asthma, such as wheezing, tightness of chest and shortness of breath [F2131]. It is also used for the maintenance of mydriasis during intraocular surgery [L4825].
DB06694XylometazolineIt is used for treating nasal congestion and minor inflammation due to allergies or colds.
DB06711NaphazolineNaphazoline is indicated for use as OTC eyedrops for ocular vasoconstriction or as a nasal preparation for nasal congestion[A176558,L5804,L5807].
DB06764TetryzolineFor temporary relief of discomfort and redness of the eye due to minor eye irritations.
DB11842Angiotensin IIAngiotensin II is a vasoconstrictor indicated for increasing blood pressure in adults with septic or other distributive shock [FDA Label].
DB00067VasopressinFor the treatment of enuresis, polyuria, diabetes insipidus, polydipsia and oesophageal varices with bleeding
DB00093FelypressinFor use as an alternative to adrenaline as a localising agent, provided that local ischaemia is not essential.
DB00211MidodrineFor the treatment of symptomatic orthostatic hypotension (OH).
DB00247MethysergideFor the treatment of vascular headache
DB00320DihydroergotamineFor the acute treatment of migraine headaches with or without aura and the acute treatment of cluster headache episodes.
DB00368NorepinephrineMainly used to treat patients in vasodilatory shock states such as septic shock and neurogenic shock and has shown a survival benefit over dopamine. Also used as a vasopressor medication for patients with critical hypotension.
DB00397PhenylpropanolamineFor the treatment of nasal congestion, control of urinary incontinence, priapism and obesity.
DB00596UlobetasolFor the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.
DB00610MetaraminolFor the treatment and prevention of hypotension due to hemorrhage, spinal anesthesia, and shock associated with brain damage
DB00669SumatriptanA combination sumatriptan and [naproxen] tablet is indicated for the treatment of migraines with or without auras in patients 12 years of age and older.[L6793] Sumatriptan nasal powder, nasal spray, subcutaneous injection, and tablets are indicated to treat migraines with or without auras in adults.[L6796,L6799,L6805,L6808,L6811] One of the subcutaneous formulations of sumatriptan is also indicated to treat cluster headaches in adults[L6805], while the other subcutaneous formulation is not.[L6808]
DB00696ErgotamineFor use as therapy to abort or prevent vascular headache, e.g., migraine, migraine variants, or so called "histaminic cephalalgia".
DB00723MethoxamineIndicated for the treatment and management of hypotension.
DB00852PseudoephedrineFor the treatment of nasal congestion, sinus congestion, Eustachian tube congestion, and vasomotor rhinitis, and as an adjunct to other agents in the optimum treatment of allergic rhinitis, croup, sinusitis, otitis media, and tracheobronchitis. Also used as first-line therapy of priapism.
DB00907CocaineFor the introduction of local (topical) anesthesia of accessible mucous membranes of the oral, laryngeal and nasal cavities.
DB00952NaratriptanFor the acute treatment of migraine attacks with or without aura in adults.
DB01364EphedrineEphedrine commonly used as a stimulant, appetite suppressant, concentration aid, decongestant, and to treat hypotension associated with anaesthesia.
DB01365MephentermineUsed to maintain blood pressure in hypotensive states.
DB02638TerlipressinCommonly used to stop bleeding of varices in the food pipe (oesophagus).
DB02860Calyculin ANot Available
DB06707LevonordefrinUsed as a topical nasal decongestant and vasoconstrictor in dentistry.
DB08985EtilefrineNot Available
DB09202CirazolineNot Available
DB09203SynephrineNot Available
DB11124RacepinephrineIndicated for temporary relief of mild symptoms of intermittent asthma.
DB13251OctopamineNot Available
DB13394AdrenaloneNot Available
DB13464OrnipressinNot Available
DB13517AngiotensinamideNot Available
DB14642LypressinNot Available
DB02234S-EthylisothioureaNot Available
DrugDrug NameTargetType
DB00935OxymetazolineAlpha-1A adrenergic receptortarget
DB00935OxymetazolineAlpha-2A adrenergic receptortarget
DB00935OxymetazolineAlpha-2C adrenergic receptortarget
DB00935OxymetazolineAlpha-2B adrenergic receptortarget
DB00935OxymetazolineAlpha-1B adrenergic receptortarget
DB00935OxymetazolineAlpha-1D adrenergic receptortarget
DB00388PhenylephrineAlpha-1A adrenergic receptortarget
DB00388PhenylephrineAlpha-1B adrenergic receptortarget
DB00388PhenylephrineAmine oxidase [flavin-containing] Aenzyme
DB00388PhenylephrineAlpha-1D adrenergic receptortarget
DB00388PhenylephrineCytochrome P450 1A2enzyme
DB00668EpinephrineAlpha-1A adrenergic receptortarget
DB00668EpinephrineBeta-1 adrenergic receptortarget
DB00668EpinephrineBeta-2 adrenergic receptortarget
DB00668EpinephrineSolute carrier family 22 member 2transporter
DB00668EpinephrineSolute carrier family 22 member 1transporter
DB00668EpinephrineCytochrome P450 2C9enzyme
DB00668EpinephrineCytochrome P450 3A4enzyme
DB00668EpinephrineAlpha-1B adrenergic receptortarget
DB00668EpinephrineAlpha-1D adrenergic receptortarget
DB00668EpinephrineAlpha-2A adrenergic receptortarget
DB00668EpinephrineAlpha-2B adrenergic receptortarget
DB00668EpinephrineTumor necrosis factortarget
DB00668EpinephrineCatechol O-methyltransferaseenzyme
DB00668EpinephrineMonoamine oxidaseenzyme
DB06694XylometazolineAlpha-2A adrenergic receptortarget
DB06694XylometazolineAlpha-1A adrenergic receptortarget
DB06694XylometazolineAlpha-1B adrenergic receptortarget
DB06694XylometazolineAlpha-1D adrenergic receptortarget
DB06694XylometazolineAlpha-2B adrenergic receptortarget
DB06694XylometazolineAlpha-2C adrenergic receptortarget
DB06711NaphazolineAlpha-1A adrenergic receptortarget
DB06711NaphazolineAlpha-2A adrenergic receptortarget
DB06764TetryzolineAlpha-1A adrenergic receptortarget
DB11842Angiotensin IIType-1 angiotensin II receptortarget
DB00067VasopressinVasopressin V1a receptortarget
DB00067VasopressinVasopressin V2 receptortarget
DB00067VasopressinVasopressin V1b receptortarget
DB00067VasopressinCanalicular multispecific organic anion transporter 1transporter
DB00093FelypressinVasopressin V1a receptortarget
DB00211MidodrineAlpha-1A adrenergic receptortarget
DB00211MidodrineAlpha-1B adrenergic receptortarget
DB00211MidodrineCytochrome P450 2D6enzyme
DB00211MidodrineSolute carrier family 15 member 1transporter
DB00211MidodrineAlpha-1D adrenergic receptortarget
DB00247Methysergide5-hydroxytryptamine receptor 2Atarget
DB00247Methysergide5-hydroxytryptamine receptor 1Atarget
DB00247Methysergide5-hydroxytryptamine receptor 7target
DB00247Methysergide5-hydroxytryptamine receptor 2Ctarget
DB00247Methysergide5-hydroxytryptamine receptor 2Btarget
DB00247Methysergide5-hydroxytryptamine receptor 1Btarget
DB00247Methysergide5-hydroxytryptamine receptor 1Ftarget
DB00247Methysergide5-hydroxytryptamine receptor 1Etarget
DB00247MethysergideCytochrome P450 3A4enzyme
DB00320Dihydroergotamine5-hydroxytryptamine receptor 1Dtarget
DB00320Dihydroergotamine5-hydroxytryptamine receptor 1Btarget
DB00320DihydroergotamineCytochrome P450 3A4enzyme
DB00320DihydroergotamineAlpha-2A adrenergic receptortarget
DB00320Dihydroergotamine5-hydroxytryptamine receptor 2Btarget
DB00320DihydroergotamineMultidrug resistance protein 1transporter
DB00368NorepinephrinePhenylalanine-4-hydroxylasetarget
DB00368NorepinephrineAlpha-1A adrenergic receptortarget
DB00368NorepinephrineAlpha-1B adrenergic receptortarget
DB00368NorepinephrineAlpha-1D adrenergic receptortarget
DB00368NorepinephrineAlpha-2A adrenergic receptortarget
DB00368NorepinephrineAlpha-2B adrenergic receptortarget
DB00368NorepinephrineAlpha-2C adrenergic receptortarget
DB00368NorepinephrineBeta-1 adrenergic receptortarget
DB00368NorepinephrineBeta-2 adrenergic receptortarget
DB00368NorepinephrineBeta-3 adrenergic receptortarget
DB00368NorepinephrineSolute carrier family 22 member 2transporter
DB00368NorepinephrineSolute carrier family 22 member 3transporter
DB00368NorepinephrineSolute carrier family 22 member 5transporter
DB00368NorepinephrineSolute carrier family 22 member 1transporter
DB00368NorepinephrinePOU domain, class 5, transcription factor 1transporter
DB00368NorepinephrineSodium-dependent noradrenaline transportertransporter
DB00368NorepinephrineSynaptic vesicular amine transportertarget
DB00368NorepinephrineChromaffin granule amine transportertarget
DB00397PhenylpropanolamineAmine oxidase [flavin-containing] Aenzyme
DB00397PhenylpropanolamineD(1A) dopamine receptortarget
DB00397PhenylpropanolamineBeta-1 adrenergic receptortarget
DB00397PhenylpropanolamineBeta-2 adrenergic receptortarget
DB00397PhenylpropanolamineAlpha-2 adrenergic receptorstarget
DB00596UlobetasolCorticosteroid-binding globulincarrier
DB00596UlobetasolGlucocorticoid receptortarget
DB00610MetaraminolAlpha-1A adrenergic receptortarget
DB00669Sumatriptan5-hydroxytryptamine receptor 1Dtarget
DB00669Sumatriptan5-hydroxytryptamine receptor 1Btarget
DB00669Sumatriptan5-hydroxytryptamine receptor 1Ftarget
DB00669SumatriptanAmine oxidase [flavin-containing] Aenzyme
DB00669Sumatriptan5-hydroxytryptamine receptor 1Atarget
DB00669SumatriptanSolute carrier organic anion transporter family member 1A2transporter
DB00669SumatriptanMultidrug resistance protein 1transporter
DB00669SumatriptanATP-binding cassette sub-family G member 2transporter
DB00669SumatriptanSolute carrier organic anion transporter family member 1B1transporter
DB00696ErgotamineAlpha-1A adrenergic receptortarget
DB00696Ergotamine5-hydroxytryptamine receptor 1Dtarget
DB00696Ergotamine5-hydroxytryptamine receptor 1Btarget
DB00696Ergotamine5-hydroxytryptamine receptor 2Atarget
DB00696ErgotamineAlpha-2A adrenergic receptortarget
DB00696ErgotamineD(2) dopamine receptortarget
DB00696ErgotamineAlpha-2B adrenergic receptortarget
DB00696ErgotamineSodium-dependent noradrenaline transportertarget
DB00696ErgotamineCytochrome P450 3A4enzyme
DB00696ErgotamineAlpha-1B adrenergic receptortarget
DB00696ErgotamineAlpha-1D adrenergic receptortarget
DB00696ErgotamineMultidrug resistance protein 1transporter
DB00696ErgotamineD(1) dopamine receptortarget
DB00696Ergotamine5-hydroxytryptamine receptor 1Atarget
DB00696Ergotamine5-hydroxytryptamine receptor 1Ftarget
DB00696Ergotamine5-hydroxytryptamine receptor 2Ctarget
DB00696Ergotamine5-hydroxytryptamine receptor 2Btarget
DB00723MethoxamineAlpha-1A adrenergic receptortarget
DB00723MethoxamineAlpha-1B adrenergic receptortarget
DB00723MethoxamineAlpha-1D adrenergic receptortarget
DB00852PseudoephedrineAlpha-1A adrenergic receptortarget
DB00852PseudoephedrineAlpha-2A adrenergic receptortarget
DB00852PseudoephedrineBeta-2 adrenergic receptortarget
DB00852PseudoephedrineAmine oxidase [flavin-containing] Aenzyme
DB00852PseudoephedrineBeta-1 adrenergic receptortarget
DB00852PseudoephedrineCytochrome P450 2D6enzyme
DB00852PseudoephedrineSodium-dependent dopamine transportertarget
DB00852PseudoephedrineSodium-dependent noradrenaline transportertarget
DB00852PseudoephedrineSodium-dependent serotonin transportertarget
DB00852PseudoephedrineNuclear factor of activated T-cells, cytoplasmic 1target
DB00852PseudoephedrineTumor necrosis factortarget
DB00852PseudoephedrineNuclear factor kappa-light-chain-enhancer of activated B cellstarget
DB00852Pseudoephedrineactivator protein 1target
DB00852PseudoephedrineInterleukin-2target
DB00907CocaineSodium-dependent noradrenaline transportertarget
DB00907CocaineSodium channel protein type 5 subunit alphatarget
DB00907CocaineSodium channel protein type 11 subunit alphatarget
DB00907CocaineSodium channel protein type 10 subunit alphatarget
DB00907CocaineSodium-dependent serotonin transportertarget
DB00907CocaineSodium-dependent dopamine transportertarget
DB00907CocaineCytochrome P450 3A4enzyme
DB00907CocaineMuscarinic acetylcholine receptor M1target
DB00907CocaineMuscarinic acetylcholine receptor M2target
DB00907CocaineCytochrome P450 3A5enzyme
DB00907CocaineCytochrome P450 3A7enzyme
DB00907CocaineCytochrome P450 2D6enzyme
DB00907CocaineSolute carrier family 22 member 2transporter
DB00907CocaineCytochrome P450 2C8enzyme
DB00907CocaineSigma non-opioid intracellular receptor 1target
DB00907CocaineLiver carboxylesterase 1target
DB00907CocaineCholinesteraseenzyme
DB00952Naratriptan5-hydroxytryptamine receptor 1Dtarget
DB00952Naratriptan5-hydroxytryptamine receptor 1Btarget
DB00952Naratriptan5-hydroxytryptamine receptor 1Ftarget
DB00952Naratriptan5-hydroxytryptamine receptor 1Atarget
DB00952NaratriptanAmine oxidase [flavin-containing] Aenzyme
DB01364EphedrineAcetylcholinesterasetarget
DB01364EphedrineAlpha-1A adrenergic receptortarget
DB01364EphedrineSodium-dependent noradrenaline transportertarget
DB01364EphedrineSynaptic vesicular amine transportertarget
DB01364EphedrineCholinesteraseenzyme
DB01365MephentermineAlpha adrenergic receptortarget
DB01365MephentermineBeta adrenergic receptortarget
DB02638TerlipressinVasopressin V1a receptortarget
DB02638TerlipressinVasopressin V2 receptortarget
DB02638TerlipressinVasopressin V1b receptortarget
DB02860Calyculin ASerine/threonine-protein phosphatase PP1-gamma catalytic subunittarget
DB06707LevonordefrinAlpha-2 adrenergic receptorstarget
DB09202CirazolineAlpha-1A adrenergic receptortarget
DB09202CirazolineAlpha-1B adrenergic receptortarget
DB09202CirazolineAlpha-1D adrenergic receptortarget
DB09202CirazolineAlpha-2 adrenergic receptorstarget
DB09203SynephrineAlpha-1 adrenergic receptorstarget
DB11124RacepinephrineAlpha-1A adrenergic receptortarget
DB11124RacepinephrineAlpha-1B adrenergic receptortarget
DB11124RacepinephrineAlpha-2A adrenergic receptortarget
DB11124RacepinephrineAlpha-2B adrenergic receptortarget
DB11124RacepinephrineAlpha-2C adrenergic receptortarget
DB11124RacepinephrineBeta-1 adrenergic receptortarget
DB11124RacepinephrineBeta-2 adrenergic receptortarget
DB11124RacepinephrineAlpha-1D adrenergic receptortarget
DB11124RacepinephrineBeta-3 adrenergic receptortarget
DB14642LypressinVasopressin V1a receptortarget
DB14642LypressinVasopressin V2 receptortarget
DB14642LypressinVasopressin V1b receptortarget
DB14642LypressinCanalicular multispecific organic anion transporter 1transporter
DB02234S-EthylisothioureaNitric oxide synthase oxygenasetarget
DB02234S-EthylisothioureaNitric oxide synthase, inducibletarget
DB02234S-EthylisothioureaNitric oxide synthase, endothelialtarget