Neuromuscular Agents

Name
Neuromuscular Agents
Accession Number
DBCAT000187
Description

Drugs used for their actions on skeletal muscle. Included are agents that act directly on skeletal muscle, those that alter neuromuscular transmission (NEUROMUSCULAR BLOCKING AGENTS), and drugs that act centrally as skeletal muscle relaxants (MUSCLE RELAXANTS, CENTRAL). Drugs used in the treatment of movement disorders are ANTI-DYSKINESIA AGENTS.

Drugs
DrugDrug Description
DantroleneA direct-acting skeletal muscle relaxant used for the treatment of management of the fulminant hypermetabolism of skeletal muscle leading to malignant hyperthermia crisis.
SuccinylcholineA depolarizing skeletal muscle relaxant used as an adjunct to anesthesia and for skeletal muscle relaxation during intubation, mechanical ventilation, and surgical procedures.
Metocurine iodideFor use as an anesthesia adjunct to induce skeletal muscle relaxation and to reduce the intensity of muscle contractions in convulsive therapy.
Gallamine triethiodideA nondepolarizing nerve blocker used in addition to anesthesia to cause skeletal muscle relaxation.
CisatracuriumA skeletal muscle relaxant used to facilitate tracheal intubation, muscle relaxation in surgery, or mechanical ventilation.
TizanidineAn alpha-2 adrenergic agonist used for the short-term treatment of muscle spasticity.
RocuroniumA vecuronium analog used to facilitate tracheal intubation and to relax skeletal muscles during surgery.
Atracurium besylateA non-depolarizing neuromuscular blocker used to facilitate endotracheal intubation and relax skeletal muscles during surgery.
DoxacuriumA nondepolarizing neuromuscular blocking agent used as an adjunct to general anesthesia to facilitate tracheal intubation, and to provide skeletal muscle relaxation during surgical procedures.
ChlormezanoneUsed in the management of anxiety and in the treatment of muscle spasm.
TubocurarineA neuromuscular blocker used for the diagnosis of and facilitation of intubation after induction of anesthesia during surgical procedures.
MivacuriumA short-acting non-depolarizing neuromuscular blocking agent used to induce anesthesia during intubation and promote skeletal muscle relaxation during surgery or mechanical ventilation.
DecamethoniumFor use as a skeletal muscle relaxant
MetocurineMetocurine is a muscle relaxant.
PancuroniumA neuromuscular blocker used as an adjunct to general anesthesia to facilitate tracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.
PipecuroniumA nondepolarizing neuromuscular blocking agent used to relax muscles during anesthesia and surgical procedures.
VecuroniumA nondepolarizing neuromuscular blocking agent used to relax muscles or as an adjunct in general anesthesia during surgical procedures.
Domoic AcidNot Available
RapacuroniumA nondepolarizing neuromuscular blocking agent used as an adjunct to general anesthesia to facilitate tracheal intubation, and to provide skeletal muscle relaxation during surgical procedures.
TolperisoneInvestigated for use/treatment in neurologic disorders, spinal cord injuries, muscle spasm, back pain, and multiple sclerosis.
Arbaclofen PlacarbilInvestigated for the treatment of spasticity in multiple sclerosis, acute back spasms, and GERD.
EperisoneEperisone is an antispasmodic drug which relaxes both skeletal muscles and vascular smooth muscles, and demonstrates a variety of effects such as reduction of myotonia, improvement of circulation, and suppression...
PyrantelAn anthelmintic used to treat helminth infections.
XylazineXylazine is a clonidine analog which acts as an agonist at α2 adrenoceptors. Veterinarians also use xylazine as an emetic, especially in cats.
NeosaxitoxinNeosaxitoxin is under investigation in clinical trial NCT01786655 (Safety Study of Long-Acting Local Anesthetic).
AtracuriumNot Annotated
TetrazepamNot Annotated
ChlorproethazineNot Annotated
MedazepamNot Annotated
MephenesinA cresol glyceryl ether used to treat muscle spasticity in Parkinson's and Multiple Sclerosis.
GallamineNot Annotated
AlcuroniumA non-depolarizing skeletal muscle relaxant similar to tubocurarine. It is used as an anesthesia adjuvant.
Botulinum toxin type AA purified form of botulinum toxin type A used to block acetylcholine release in the treatment of chronic sialorrhea, muscle spasticity, and dystonia, as well as in cosmetic applications.
QuinineAn alkaloid used to treat uncomplicated Plasmodium falciparum malaria.
Y-27632Y-27632 is an inhibitor of Rho-associated protein kinase. It inhibits calcium sensitization to affect smooth muscle relaxation.
Drugs & Drug Targets
DrugTargetType
DantroleneRyanodine receptor 1target
DantroleneThyroxine-binding globulincarrier
SuccinylcholineMuscarinic acetylcholine receptor M1target
SuccinylcholineCholinesteraseenzyme
SuccinylcholineMuscarinic acetylcholine receptor M2target
SuccinylcholineMuscarinic acetylcholine receptor M3target
SuccinylcholineAlpha-7 nicotinic cholinergic receptor subunittarget
SuccinylcholineNeuronal acetylcholine receptor subunit alpha-10target
Metocurine iodideNeuronal acetylcholine receptor subunit alpha-2target
Gallamine triethiodideNeuronal acetylcholine receptor subunit alpha-2target
Gallamine triethiodideMuscarinic acetylcholine receptor M2target
Gallamine triethiodideAcetylcholinesterasetarget
Gallamine triethiodideMuscarinic acetylcholine receptor M1target
Gallamine triethiodideMuscarinic acetylcholine receptor M5target
CisatracuriumNeuronal acetylcholine receptor subunit alpha-2target
TizanidineAlpha-2 adrenergic receptorstarget
TizanidineCytochrome P450 1A2enzyme
TizanidineNischarintarget
TizanidineAlpha-1 adrenergic receptorstarget
RocuroniumNeuronal acetylcholine receptor subunit alpha-2target
RocuroniumMuscarinic acetylcholine receptor M2target
Rocuronium5-hydroxytryptamine receptor 3Atarget
RocuroniumSolute carrier family 22 member 1transporter
RocuroniumSolute carrier organic anion transporter family member 1A2transporter
Atracurium besylateNeuronal acetylcholine receptor subunit alpha-2target
DoxacuriumNeuronal acetylcholine receptor subunit alpha-2target
DoxacuriumMuscarinic acetylcholine receptor M2target
DoxacuriumCholinesteraseenzyme
ChlormezanoneTranslocator proteintarget
TubocurarineNeuronal acetylcholine receptor subunit alpha-2target
TubocurarineAcetylcholinesterasetarget
Tubocurarine5-hydroxytryptamine receptor 3Atarget
TubocurarineSolute carrier family 22 member 1transporter
TubocurarineSolute carrier family 22 member 2transporter
TubocurarineNeuronal acetylcholine receptor subunit alpha-7target
TubocurarineCholinesteraseenzyme
MivacuriumNeuronal acetylcholine receptor subunit alpha-2target
MivacuriumMuscarinic acetylcholine receptor M2target
MivacuriumMuscarinic acetylcholine receptor M3target
MivacuriumCholinesterasetarget
DecamethoniumNeuronal acetylcholine receptor subunit alpha-2target
DecamethoniumAcetylcholinesterasetarget
DecamethoniumCholinesteraseenzyme
DecamethoniumNeuronal acetylcholine receptor subunit alpha-4target
DecamethoniumNeuronal acetylcholine receptor subunit beta-2target
MetocurineNeuronal acetylcholine receptor subunit alpha-2target
MetocurineMuscarinic acetylcholine receptor M2target
PancuroniumNeuronal acetylcholine receptor subunit alpha-2target
PancuroniumCholinesteraseenzyme
PancuroniumMuscarinic acetylcholine receptor M2target
PancuroniumMuscarinic acetylcholine receptor M3target
PancuroniumSolute carrier family 22 member 1transporter
PancuroniumSolute carrier family 22 member 2transporter
PipecuroniumNeuronal acetylcholine receptor subunit alpha-2target
PipecuroniumMuscarinic acetylcholine receptor M2target
PipecuroniumMuscarinic acetylcholine receptor M3target
PipecuroniumCholinesteraseenzyme
VecuroniumP-glycoprotein 1transporter
VecuroniumNeuronal acetylcholine receptor subunit alpha-2target
Domoic AcidGlutamate receptor ionotropic, kainate 2target
RapacuroniumMuscarinic acetylcholine receptor M2target
TolperisoneCytochrome P450 1A2enzyme
Arbaclofen PlacarbilMonocarboxylate transporter 1transporter
Arbaclofen PlacarbilGamma-aminobutyric acid type B receptor subunit 1target
Arbaclofen PlacarbilGamma-aminobutyric acid type B receptor subunit 2target
EperisoneCytochrome P450 3A4enzyme
PyrantelG-protein coupled receptor 35target
PyrantelCytochrome P450 4A11enzyme
PyrantelMuscarinic acetylcholine receptor M1target
XylazineAlpha-2 adrenergic receptorstarget
MedazepamGABA(A) Receptortarget
MedazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
Botulinum toxin type ASynaptosomal-associated protein 25target
Botulinum toxin type ARho-related GTP-binding protein RhoBtarget
QuininePlatelet glycoprotein IXtarget
QuinineIntermediate conductance calcium-activated potassium channel protein 4target
QuinineCytochrome P450 3A4enzyme
QuinineCytochrome P450 3A5enzyme
QuinineCytochrome P450 1A1enzyme
QuinineCytochrome P450 2D6enzyme
QuinineCytochrome P450 1A2enzyme
QuinineCytochrome P450 2C8enzyme
QuinineCytochrome P450 2C9enzyme
QuinineCytochrome P450 2C19enzyme
QuinineCytochrome P450 2E1enzyme
QuinineCytochrome P450 3A7enzyme
QuinineSolute carrier family 22 member 2transporter
QuinineSolute carrier family 22 member 1transporter
QuinineSolute carrier family 22 member 5transporter
QuinineP-glycoprotein 1transporter
QuinineSolute carrier organic anion transporter family member 1A2transporter
QuinineSolute carrier family 22 member 4transporter
QuinineFe(II)-protoporphyrin IXtarget
QuinineSolute carrier organic anion transporter family member 1B1transporter
Y-27632cAMP-dependent protein kinase catalytic subunit alphatarget
Y-27632cAMP-dependent protein kinase inhibitor alphatarget
Y-27632Rho-associated protein kinase 1target
Y-27632Rho-associated protein kinase 2target