Neuromuscular Agents

Drugs used for their actions on skeletal muscle. Included are agents that act directly on skeletal muscle, those that alter neuromuscular transmission (NEUROMUSCULAR BLOCKING AGENTS), and drugs that act centrally as skeletal muscle relaxants (MUSCLE RELAXANTS, CENTRAL). Drugs used in the treatment of movement disorders are ANTI-DYSKINESIA AGENTS.
DrugDrug NameDrug Indication
DB01219DantroleneFor use, along with appropriate supportive measures, for the management of the fulminant hypermetabolism of skeletal muscle characteristic of malignant hyperthermia crises in patients of all ages. Also used preoperatively, and sometimes postoperatively, to prevent or attenuate the development of clinical and laboratory signs of malignant hyperthermia in individuals judged to be malignant hyperthermia susceptible.
DB00202SuccinylcholineUsed in surgical procedures where a rapid onset and brief duration of muscle relaxation is needed (includes intubation, endoscopies, and ECT)
DB00416Metocurine IodideFor use as an anesthesia adjunct to induce skeletal muscle relaxation and to reduce the intensity of muscle contractions in convulsive therapy.
DB00483Gallamine TriethiodideFor use as adjuncts to anesthesia to induce skeletal muscle relaxation and to facilitate the management of patients undergoing mechanical ventilation
DB00565CisatracuriumFor inpatients and outpatients as an adjunct to general anesthesia, to facilitate tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation in the ICU.
DB00697TizanidineFor the management of increased muscle tone associated with spasticity
DB00728RocuroniumFor inpatients and outpatients as an adjunct to general anesthesia to facilitate both rapid sequence and routine tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation.
DB00732Atracurium besylateFor use, as an adjunct to general anesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.
DB01135DoxacuriumUsed to provide skeletal muscle relaxation as an adjunct to general anesthesia, for endotracheal intubation or to facilitate mechanical ventilation.
DB01178ChlormezanoneUsed in the management of anxiety and in the treatment of muscle spasm.
DB01199TubocurarineUsed as a diagnosis agent for myasthenia gravis, and also to facilitate the intubation after induction of anesthesia in surgical procedure
DB01226MivacuriumFor inpatients and outpatients, as an adjunct to general anesthesia, to facilitate tracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.
DB01245DecamethoniumFor use as a skeletal muscle relaxant
DB01336MetocurineMetocurine is a muscle relaxant.
DB01337PancuroniumUsed as a muscle relaxant during anesthesia and surgical procedures.
DB01338PipecuroniumUsed as a muscle relaxant during anesthesia and surgical procedures.
DB01339VecuroniumVecuronium is a muscle relaxing agent and is used as an ajunct in general anesthesia.
DB02852Domoic AcidNot Available
DB04834RapacuroniumUsed in anaesthesia, to aid and enable endotracheal intubation.
DB06264TolperisoneInvestigated for use/treatment in neurologic disorders, spinal cord injuries, muscle spasm, back pain, and multiple sclerosis.
DB08892Arbaclofen PlacarbilInvestigated for the treatment of spasticity in multiple sclerosis, acute back spasms, and GERD.
DB08992EperisoneNot Available
DB11156PyrantelFor the treatment of enterobiasis including roundworm (ascariasis), pinworm (enterobius) and hookworm (strongyloides) and hookworm (ancylostoma) in the pyrantel pamoate form [L1893]. Pyrantel is available in various formulations for humans, dogs, and cats as the pamoate (US Pharmacopeia nomenclature) or embonate (European Pharmacopoeia nomenclature) salt, which contains 34.7% pyrantel base combined with pamoic acid [L1893]. [L1900], [A32283]. Pyrantel pamoate (embonate) ingested orally is effective for removal and control of ascarid and hookworm infections in puppies and dogs (adult Toxocara canis, Toxascaris leonina, Ancylostoma tubaeforme, An. braziliense, Uncinaria stenocephala), cats (adult Toxocara cati, Toxa. leonina, An. caninum, An. braziliense, U. stenocephala), horses and ponies (adult and immature Parascaris equorum, adult Strongylus vulgaris, S. edentatus, S. equinus, Cyathostomes (Triodontophorus spp., Cyathostomum spp., Cylicodontophorus spp., Cylicocyclus spp., Cylicostephanus spp., Poteriostomum spp.), Oxyuris equi, Anoplocephala perfoliata), swine (adult Ascaris suum, Oesophagostomum dentatum), and humans (adult A. lumbricoides, Enterobius vermicularis, An. duodenale, Necator americanus) [L1900].
DB11477XylazineNot Available
DB12989NeosaxitoxinNot Available
DB13295AtracuriumNot Available
DB13583MephenesinMephenesin was used for the treatment of muscle spasticity in diseases like Parkinson's or Multiple Sclerosis.
DrugDrug NameTargetType
DB01219DantroleneCytochrome P450 3A4enzyme
DB01219DantroleneRyanodine receptor 1target
DB00202SuccinylcholineCholinesteraseenzyme
DB00202SuccinylcholineMuscarinic acetylcholine receptor M1target
DB00202SuccinylcholineMuscarinic acetylcholine receptor M2target
DB00202SuccinylcholineMuscarinic acetylcholine receptor M3target
DB00202SuccinylcholineAlpha-7 nicotinic cholinergic receptor subunittarget
DB00202SuccinylcholineNeuronal acetylcholine receptor subunit alpha-10target
DB00416Metocurine IodideNeuronal acetylcholine receptor subunit alpha-2target
DB00483Gallamine TriethiodideNeuronal acetylcholine receptor subunit alpha-2target
DB00483Gallamine TriethiodideMuscarinic acetylcholine receptor M2target
DB00483Gallamine TriethiodideAcetylcholinesterasetarget
DB00483Gallamine TriethiodideMuscarinic acetylcholine receptor M1target
DB00483Gallamine TriethiodideMuscarinic acetylcholine receptor M5target
DB00565CisatracuriumNeuronal acetylcholine receptor subunit alpha-2target
DB00697TizanidineCytochrome P450 1A2enzyme
DB00697TizanidineAlpha-2A adrenergic receptortarget
DB00697TizanidineAlpha-2B adrenergic receptortarget
DB00697TizanidineAlpha-2C adrenergic receptortarget
DB00697TizanidineNischarintarget
DB00728RocuroniumNeuronal acetylcholine receptor subunit alpha-2target
DB00728RocuroniumMuscarinic acetylcholine receptor M2target
DB00728Rocuronium5-hydroxytryptamine receptor 3Atarget
DB00728RocuroniumSolute carrier family 22 member 1transporter
DB00728RocuroniumSolute carrier organic anion transporter family member 1A2transporter
DB00732Atracurium besylateNeuronal acetylcholine receptor subunit alpha-2target
DB01135DoxacuriumCholinesteraseenzyme
DB01135DoxacuriumNeuronal acetylcholine receptor subunit alpha-2target
DB01135DoxacuriumMuscarinic acetylcholine receptor M2target
DB01178ChlormezanoneTranslocator proteintarget
DB01199TubocurarineNeuronal acetylcholine receptor subunit alpha-2target
DB01199TubocurarineAcetylcholinesterasetarget
DB01199Tubocurarine5-hydroxytryptamine receptor 3Atarget
DB01199TubocurarineNeuronal acetylcholine receptor subunit alpha-7target
DB01199TubocurarineSolute carrier family 22 member 1transporter
DB01199TubocurarineSolute carrier family 22 member 2transporter
DB01226MivacuriumNeuronal acetylcholine receptor subunit alpha-2target
DB01226MivacuriumMuscarinic acetylcholine receptor M2target
DB01226MivacuriumMuscarinic acetylcholine receptor M3target
DB01226MivacuriumCholinesterasetarget
DB01245DecamethoniumCholinesteraseenzyme
DB01245DecamethoniumNeuronal acetylcholine receptor subunit alpha-2target
DB01245DecamethoniumAcetylcholinesterasetarget
DB01245DecamethoniumNeuronal acetylcholine receptor subunit alpha-4target
DB01245DecamethoniumNeuronal acetylcholine receptor subunit beta-2target
DB01336MetocurineNeuronal acetylcholine receptor subunit alpha-2target
DB01336MetocurineMuscarinic acetylcholine receptor M2target
DB01337PancuroniumCholinesteraseenzyme
DB01337PancuroniumNeuronal acetylcholine receptor subunit alpha-2target
DB01337PancuroniumMuscarinic acetylcholine receptor M2target
DB01337PancuroniumMuscarinic acetylcholine receptor M3target
DB01337PancuroniumSolute carrier family 22 member 1transporter
DB01337PancuroniumSolute carrier family 22 member 2transporter
DB01338PipecuroniumCholinesteraseenzyme
DB01338PipecuroniumNeuronal acetylcholine receptor subunit alpha-2target
DB01338PipecuroniumMuscarinic acetylcholine receptor M2target
DB01338PipecuroniumMuscarinic acetylcholine receptor M3target
DB01339VecuroniumNeuronal acetylcholine receptor subunit alpha-2target
DB01339VecuroniumSolute carrier family 22 member 1transporter
DB01339VecuroniumMultidrug resistance protein 1transporter
DB02852Domoic AcidGlutamate receptor ionotropic, kainate 2target
DB04834RapacuroniumMuscarinic acetylcholine receptor M2target
DB06264TolperisoneCytochrome P450 1A2enzyme
DB08892Arbaclofen PlacarbilGamma-aminobutyric acid type B receptor subunit 1target
DB08892Arbaclofen PlacarbilGamma-aminobutyric acid type B receptor subunit 2target
DB08892Arbaclofen PlacarbilMonocarboxylate transporter 1transporter
DB08992EperisoneCytochrome P450 3A4enzyme
DB11156PyrantelCytochrome P450 4A11enzyme
DB11156PyrantelG-protein coupled receptor 35target
DB11156PyrantelMuscarinic acetylcholine receptor M1target
DB11477XylazineAlpha-2 adrenergic receptorstarget