Growth Inhibitors

Endogenous or exogenous substances which inhibit the normal growth of human and animal cells or micro-organisms, as distinguished from those affecting plant growth (= PLANT GROWTH REGULATORS).
DrugDrug NameDrug Indication
DB00112BevacizumabAs part of combination therapy for metastatic colorectal cancer and HER2-negative metastatic breast cancer.
DB00480LenalidomideLenalidomide is indicated for the treatment of multiple myeloma in combination with dexamethasone. It is also indicated for the treatment of patients with transfusion-dependent anemia due to low- or intermediate- risk myelodysplastic syndromes (MDS) associated with a deletion 5q cytogenetic abnormality with or without additional cytogenetic abnormalities.
DB01041ThalidomideFor the acute treatment of the cutaneous manifestations of moderate to severe erythema nodosum leprosum (ENL). Also for use as maintenance therapy for prevention and suppression of the cutaneous manifestations of ENL recurrence.
DB01169Arsenic trioxideFor induction of remission and consolidation in patients with acute promyelocytic leukemia (APL), and whose APL is characterized by the presence of the t(15;17) translocation or PML/RAR-alpha gene expression
DB01268SunitinibFor the treatment of advanced renal cell carcinoma as well as the treatment of gastrointestinal stromal tumor after disease progression on or intolerance to imatinib mesylate.
DB01270RanibizumabFor the treatment of patients with macular edema after retinal vein occlusion, age-related macular degeneration (wet), and diabetic macular edema.
DB02640FumagillinNot Available
DB03496AlvocidibInvestigated for use/treatment in esophageal cancer, leukemia (lymphoid), lung cancer, liver cancer, and lymphoma (unspecified).
DB04865Omacetaxine mepesuccinateUsed in patients who are intolerant and/or resistant to two or more tyrosine kinase inhibitors used to treat accelerated or chronic phase CML.
DB04866HalofuginoneFor the treatment of scleroderma, cancer, and restenosis.
DB05088TetrathiomolybdateInvestigated for use/treatment in liver disease and pulmonary fibrosis.
DB05779OglufanideInvestigated for use/treatment in hepatitis (viral, C).
DB06423EndostatinInvestigated for use/treatment in cancer/tumors (unspecified), macular degeneration, and diabetic retinopathy.
DB06436SemaxanibInvestigated for use/treatment in colorectal cancer and lung cancer.
DB06461SqualamineInvestigated for use/treatment in ovarian cancer, lung cancer, and macular degeneration.
DB08910PomalidomidePomalidomide is indicated for patients with multiple myeloma who have received at least two prior therapies including lenalidomide and bortezomib and have demonstrated disease progression on or within 60 days of completion of the last therapy.
DB11366RoquinimexRoquinimex is investigated to be used as a treatment of a number of cancers and autoimmune conditions. As well, roquinimex is researched to be used as adjuvant therapy after bone marrow transplantation in cases of acute leukemia.
DB12056TrebananibNot Available
DB12081AnecortaveNot Available
DB13182DaidzeinNot Available
DB08633TNP-470Not Available
DrugDrug NameTargetType
DB00112BevacizumabLow affinity immunoglobulin gamma Fc region receptor III-Btarget
DB00112BevacizumabComplement C1r subcomponenttarget
DB00112BevacizumabComplement C1q subcomponent subunit Atarget
DB00112BevacizumabComplement C1q subcomponent subunit Btarget
DB00112BevacizumabComplement C1q subcomponent subunit Ctarget
DB00112BevacizumabLow affinity immunoglobulin gamma Fc region receptor III-Atarget
DB00112BevacizumabHigh affinity immunoglobulin gamma Fc receptor Itarget
DB00112BevacizumabLow affinity immunoglobulin gamma Fc region receptor II-atarget
DB00112BevacizumabLow affinity immunoglobulin gamma Fc region receptor II-btarget
DB00112BevacizumabLow affinity immunoglobulin gamma Fc region receptor II-ctarget
DB00112BevacizumabVascular endothelial growth factor Atarget
DB00480LenalidomideProstaglandin G/H synthase 2target
DB00480LenalidomideTumor necrosis factor ligand superfamily member 11target
DB00480LenalidomideProtein cereblontarget
DB00480LenalidomideMultidrug resistance protein 1transporter
DB01041ThalidomideTumor necrosis factortarget
DB01041ThalidomideNuclear factor NF-kappa-B p105 subunittarget
DB01041ThalidomideProstaglandin G/H synthase 2target
DB01041ThalidomideCytochrome P450 2C19enzyme
DB01041ThalidomideCytochrome P450 1A1enzyme
DB01041ThalidomideCytochrome P450 2E1enzyme
DB01041ThalidomideCytochrome P450 2C9enzyme
DB01041ThalidomideProstaglandin G/H synthase 1enzyme
DB01041ThalidomideProstaglandin G/H synthase 2enzyme
DB01041ThalidomideCytochrome P450 3A5enzyme
DB01041ThalidomideFibroblast growth factor receptor 2target
DB01041ThalidomideProtein cereblontarget
DB01041ThalidomideNuclear factor kappa-light-chain-enhancer of activated B cellstarget
DB01041Thalidomidealpha1-acid glycoproteintarget
DB01169Arsenic trioxideInhibitor of nuclear factor kappa-B kinase subunit betatarget
DB01169Arsenic trioxideTranscription factor AP-1target
DB01169Arsenic trioxideG1/S-specific cyclin-D1target
DB01169Arsenic trioxideMitogen-activated protein kinase 3target
DB01169Arsenic trioxideMitogen-activated protein kinase 1target
DB01169Arsenic trioxideRAC-alpha serine/threonine-protein kinasetarget
DB01169Arsenic trioxideCytochrome P450 1A1enzyme
DB01169Arsenic trioxideCanalicular multispecific organic anion transporter 1transporter
DB01169Arsenic trioxideThioredoxin reductase 1, cytoplasmictarget
DB01169Arsenic trioxideMultidrug resistance protein 1transporter
DB01169Arsenic trioxideCytochrome P450 1B1enzyme
DB01169Arsenic trioxideCytochrome P450 3A4enzyme
DB01169Arsenic trioxideCyclin-dependent kinase inhibitor 1target
DB01169Arsenic trioxideHistone deacetylase 1target
DB01169Arsenic trioxideProtein PMLtarget
DB01169Arsenic trioxideSerum albumincarrier
DB01268SunitinibPlatelet-derived growth factor receptor betatarget
DB01268SunitinibVascular endothelial growth factor receptor 1target
DB01268SunitinibVascular endothelial growth factor receptor 2target
DB01268SunitinibVascular endothelial growth factor receptor 3target
DB01268SunitinibMast/stem cell growth factor receptor Kittarget
DB01268SunitinibReceptor-type tyrosine-protein kinase FLT3target
DB01268SunitinibMacrophage colony-stimulating factor 1 receptortarget
DB01268SunitinibPlatelet-derived growth factor receptor alphatarget
DB01268SunitinibCytochrome P450 3A4enzyme
DB01268SunitinibCytochrome P450 3A5enzyme
DB01268SunitinibCytochrome P450 3A7enzyme
DB01268SunitinibMultidrug resistance-associated protein 4transporter
DB01268SunitinibMultidrug resistance protein 1transporter
DB01268SunitinibCanalicular multispecific organic anion transporter 1transporter
DB01268SunitinibATP-binding cassette sub-family G member 2transporter
DB01270RanibizumabVascular endothelial growth factor Atarget
DB02640FumagillinMethionine aminopeptidase 2target
DB03496AlvocidibGlycogen phosphorylase, muscle formtarget
DB03496AlvocidibCyclin-dependent kinase 7target
DB03496AlvocidibCyclin-dependent kinase 5target
DB03496AlvocidibCyclin-dependent kinase 9target
DB03496AlvocidibCyclin-dependent kinase 1target
DB03496AlvocidibCyclin-dependent kinase 6target
DB03496AlvocidibEpidermal growth factor receptortarget
DB03496AlvocidibCyclin-dependent kinase 4target
DB03496AlvocidibCyclin-dependent kinase 8target
DB03496AlvocidibCyclin-dependent kinase 2target
DB03496AlvocidibATP-binding cassette sub-family G member 2transporter
DB03496AlvocidibGlycogen phosphorylase, brain formtarget
DB03496AlvocidibGlycogen phosphorylase, liver formtarget
DB03496AlvocidibUDP-glucuronosyltransferase 1-1enzyme
DB04865Omacetaxine mepesuccinate50S ribosomal protein L2target
DB04865Omacetaxine mepesuccinate60S ribosomal protein L3target
DB04866HalofuginoneCollagen alpha-1(I) chaintarget
DB04866Halofuginone72 kDa type IV collagenasetarget
DB05088TetrathiomolybdateAmyloid beta A4 proteintarget
DB06423Endostatin72 kDa type IV collagenasetarget
DB06423EndostatinMatrix metalloproteinase-9target
DB06423EndostatinCollagenase 3target
DB06423EndostatinFocal adhesion kinase 1target
DB06423EndostatinCytochrome P450 19A1enzyme
DB06436SemaxanibVascular endothelial growth factor receptor 2target
DB06436SemaxanibProstaglandin G/H synthase 2enzyme
DB08910PomalidomideCytochrome P450 1A2enzyme
DB08910PomalidomideCytochrome P450 3A4enzyme
DB08910PomalidomideMultidrug resistance protein 1transporter
DB08910PomalidomideProtein cereblontarget
DB08910PomalidomideTumor necrosis factortarget
DB08910PomalidomideProstaglandin G/H synthase 2target
DB08633TNP-470Methionine aminopeptidase 2target