Bevacizumab

Identification

Name
Bevacizumab
Accession Number
DB00112  (BTD00087, BIOD00087)
Type
Biotech
Groups
Approved, Investigational
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Description

A recombinant humanized monoclonal IgG1 antibody that binds to and inhibits the biologic activity of human vascular endothelial growth factor (VEGF). Bevacizumab contains human framework regions and the complementarity-determining regions of a murine antibody that binds to VEGF. Bevacizumab is produced in a Chinese Hamster Ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin and has a molecular weight of approximately 149 kilodaltons.

Protein structure
Db00112
Protein chemical formula
C6538H10034N1716O2033S44
Protein average weight
149000.0 Da
Sequences
>"Bevacizumab light chain"
DIQMTQSPSSLSASVGDRVTITCSASQDISNYLNWYQQKPGKAPKVLIYFTSSLHSGVPS
RFSGSGSGTDFTLTISSLQPEDFATYYCQQYSTVPWTFGQGTKVEIKRTVAAPSVFIFPP
SDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLT
LSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
>"Bevacizumab heavy chain"
EVQLVESGGGLVQPGGSLRLSCAASGYTFTNYGMNWVRQAPGKGLEWVGWINTYTGEPTY
AADFKRRFTFSLDTSKSTAYLQMNSLRAEDTAVYYCAKYPHYYGSSHWYFDVWGQGTLVT
VSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVL
QSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEL
LGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREE
QYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPS
REEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDK
SRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
Download FASTA Format
Synonyms
  • antiVEGF
  • bevacizumab-awwb
External IDs
R-435
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
AvastinInjection, solution100 mg/4mLIntravenousGenentech, Inc.2004-02-26Not applicableUs
AvastinSolution25 mgIntravenousHoffmann La Roche2005-11-02Not applicableCanada
AvastinInjection, solution400 mg/16mLIntravenousGenentech, Inc.2004-02-26Not applicableUs
MvasiInjection, solution400 mg/16mLIntravenousAmgen2018-06-01Not applicableUs
MvasiInjection, solution100 mg/4mLIntravenousAmgen2018-06-01Not applicableUs
International/Other Brands
Avastin
Categories
UNII
2S9ZZM9Q9V
CAS number
216974-75-3

Pharmacology

Indication

As part of combination therapy for metastatic colorectal cancer and HER2-negative metastatic breast cancer.

Associated Conditions
Pharmacodynamics

Bevacizumab is an antineoplastic agent and prevents or reduces the formation of blood vessels (angiogenesis) thereby preventing or reducing metatstatic disease progressing. Bevacizumab binds VEGF and prevents vascular endothelial growth and endothelial cell proliferation.

Mechanism of action

Bevacizumab contains human framework regions with antigen binding regions of a humanised murine antibody that binds to VEGF. Bevacizumab is produced by recombinant DNA technology in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin and is purified by a process that includes specific viral inactivation and removal steps. Bevacizumab binds VEGF and prevents the interaction of VEGF to its receptors (Flt-1 and KDR) on the surface of endothelial cells. This prevents blood vessel proliferation and in response retardation of metastatic tumor growth occurs.

TargetActionsOrganism
AVascular endothelial growth factor ANot AvailableHuman
ULow affinity immunoglobulin gamma Fc region receptor III-BNot AvailableHuman
UComplement C1r subcomponentNot AvailableHuman
UComplement C1q subcomponent subunit ANot AvailableHuman
UComplement C1q subcomponent subunit BNot AvailableHuman
UComplement C1q subcomponent subunit CNot AvailableHuman
ULow affinity immunoglobulin gamma Fc region receptor III-ANot AvailableHuman
UHigh affinity immunoglobulin gamma Fc receptor INot AvailableHuman
ULow affinity immunoglobulin gamma Fc region receptor II-aNot AvailableHuman
ULow affinity immunoglobulin gamma Fc region receptor II-bNot AvailableHuman
ULow affinity immunoglobulin gamma Fc region receptor II-cNot AvailableHuman
Absorption
Not Available
Volume of distribution

Vd: 46 mL/kg

Protein binding
Not Available
Metabolism

Most likely removed by opsonization via the reticuloendothelial system when bound to endothelial cells, or by human antimurine antibody production

Route of elimination
Not Available
Half life

approximately 20 days (range: 11–50 days)

Clearance
  • 0.26 L/day [Male patients who received 1 to 20 mg/kg of Avastin weekly, every 2 weeks, or every 3 weeks]
  • 0.21 L/day [Female patients who received 1 to 20 mg/kg of Avastin weekly, every 2 weeks, or every 3 weeks]
  • 0.25 L/day [Patients with higher tumor burden who received 1 to 20 mg/kg of Avastin weekly, every 2 weeks, or every 3 weeks]
  • 0.2 L/day [patients with tumor burdens below the median who received 1 to 20 mg/kg of Avastin weekly, every 2 weeks, or every 3 weeks]

Clearance varies by body weight, gender, and tumor burden. Increased clearance observed in men and in patients with higher tumor burden; however, no evidence of reduced efficacy.

Toxicity

Category C in pregnancy. No studies on lactating patients: recommended to discontinue the drug or discontinue lactation. No extensive studies in pediatrics. In geriatrics: increased risk of proteinuria, arterial thromboembolic events, as well as GI bleeding and sepsis among others.

Affected organisms
  • Humans and other mammals
Pathways
PathwayCategory
Bevacizumab Action PathwayDrug action
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
2-MethoxyethanolThe risk or severity of adverse effects can be increased when 2-Methoxyethanol is combined with Bevacizumab.
9-(N-methyl-L-isoleucine)-cyclosporin AThe risk or severity of adverse effects can be increased when 9-(N-methyl-L-isoleucine)-cyclosporin A is combined with Bevacizumab.
AbataceptThe risk or severity of adverse effects can be increased when Abatacept is combined with Bevacizumab.
AbciximabThe risk or severity of adverse effects can be increased when Abciximab is combined with Bevacizumab.
AbetimusThe risk or severity of adverse effects can be increased when Abetimus is combined with Bevacizumab.
AbituzumabThe risk or severity of adverse effects can be increased when Bevacizumab is combined with Abituzumab.
AcetyldigitoxinAcetyldigitoxin may decrease the cardiotoxic activities of Bevacizumab.
AcetyldigoxinAcetyldigoxin may decrease the cardiotoxic activities of Bevacizumab.
ActeosideThe risk or severity of adverse effects can be increased when Acteoside is combined with Bevacizumab.
AdalimumabThe risk or severity of adverse effects can be increased when Adalimumab is combined with Bevacizumab.
Food Interactions
Not Available

References

General References
  1. Velcheti V, Viswanathan A, Govindan R: The proportion of patients with metastatic non-small cell lung cancer potentially eligible for treatment with bevacizumab: a single institutional survey. J Thorac Oncol. 2006 Jun;1(5):501. [PubMed:17409907]
  2. Link [Link]
External Links
PubChem Substance
46504473
ChEMBL
CHEMBL1201583
Therapeutic Targets Database
DAP000393
PharmGKB
PA130232992
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
Wikipedia
Bevacizumab
ATC Codes
L01XC07 — Bevacizumab
AHFS Codes
  • 10:00.00 — Antineoplastic Agents
FDA label
Download (133 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0Active Not RecruitingTreatmentClear Cell Renal Cell Carcinoma / Metastatic Renal Cell Cancer / Renal Cancers / Stage IV Renal Cell Cancer AJCC V71
0CompletedBasic ScienceGlioblastoma Multiforme (GBM)1
0CompletedTreatmentCancer, Breast1
0CompletedTreatmentDiffuse Intrinsic Pontine Glioma (DIPG) / Newly Diagnosed High-Grade Gliomas1
0CompletedTreatmentHead and Neck Carcinoma / Pharynx Cancer1
0Not Yet RecruitingNot AvailableEnd Stage Renal Disease (ESRD) / Hemodialysis Vascular Access Failure1
0Not Yet RecruitingTreatmentChildhood CNS Tumor1
0RecruitingBasic ScienceBevacizumab-alone Maintenance Treatment Progression / Metastatic Breast Cancer (MBC)1
0RecruitingBasic ScienceCancer, Breast / Early-Stage Breast Carcinoma / Human Epidermal Growth Factor 2 Negative Carcinoma of Breast1
0RecruitingPreventionTumors, Solid1
0RecruitingTreatmentPrimary Esophageal Carcinoma1
0SuspendedTreatmentGlioblastomas / Neoplasms, Brain1
0TerminatedTreatmentGlioblastomas / Gliosarcoma / Neoplasms, Brain1
0TerminatedTreatmentHemangioblastomas / Von Hippel Lindau Disease1
0Unknown StatusTreatmentGlioblastomas / Optic Neuropathies1
1Active Not RecruitingNot AvailableHealthy Volunteers1
1Active Not RecruitingDiagnosticCancers / Lung Cancer Non-Small Cell Cancer (NSCLC)1
1Active Not RecruitingTreatmentAdult Glioblastoma / Endometrial Clear Cell Adenocarcinoma / Endometrial Serous Adenocarcinoma / Ovarian Clear Cell Cystadenocarcinoma / Ovarian Endometrioid Adenocarcinoma / Ovarian Mucinous Cystadenocarcinoma / Ovarian Serous Cystadenocarcinoma / Recurrent Fallopian Tube Carcinoma / Recurrent Ovarian Carcinoma / Recurrent Primary Peritoneal Carcinoma / Recurrent Uterine Corpus Carcinoma / Solid Neoplasms / Stage IIIA Fallopian Tube Cancer / Stage IIIA Fallopian Tube Cancer AJCC v7 / Stage IIIA Ovarian Cancer / Stage IIIA Ovarian Cancer AJCC v6 and v7 / Stage IIIA Primary Peritoneal Cancer / Stage IIIA Primary Peritoneal Cancer AJCC v7 / Stage IIIB Fallopian Tube Cancer / Stage IIIB Fallopian Tube Cancer AJCC v7 / Stage IIIB Ovarian Cancer / Stage IIIB Ovarian Cancer AJCC v6 and v7 / Stage IIIB Primary Peritoneal Cancer / Stage IIIB Primary Peritoneal Cancer AJCC v7 / Stage IIIC Fallopian Tube Cancer / Stage IIIC Fallopian Tube Cancer AJCC v7 / Stage IIIC Ovarian Cancer / Stage IIIC Ovarian Cancer AJCC v6 and v7 / Stage IIIC Primary Peritoneal Cancer / Stage IIIC Primary Peritoneal Cancer AJCC v7 / Stage IV Fallopian Tube Cancer / Stage IV Fallopian Tube Cancer AJCC v6 and v7 / Stage IV Ovarian Cancer / Stage IV Ovarian Cancer AJCC v6 and v7 / Stage IV Primary Peritoneal Cancer / Stage IV Primary Peritoneal Cancer AJCC v71
1Active Not RecruitingTreatmentAdvanced Cancers1
1Active Not RecruitingTreatmentCancer of the Ovary / Fallopian Tube Cancer / Malignant Peritoneal Neoplasm1
1Active Not RecruitingTreatmentCancer of the Ovary / Fallopian Tube Cancer / No Prior Chemotherapy / Primary Peritoneal Cancer1
1Active Not RecruitingTreatmentCancer of the Ovary / Fallopian Tube Cancer / Primary Peritoneal Cancer1
1Active Not RecruitingTreatmentCancer of the Ovary / Fallopian Tube Cancer / Primary Peritoneal Cancer / Primary Peritoneal Carcinoma1
1Active Not RecruitingTreatmentCancer, Advanced5
1Active Not RecruitingTreatmentCancer, Advanced / Tumors, Solid1
1Active Not RecruitingTreatmentCancer, Breast / Colorectal Cancers / Esophagogastric Cancer / Lung Cancer Non-Small Cell Cancer (NSCLC) / Malignant Neoplasm of Pancreas / Tumors1
1Active Not RecruitingTreatmentCancers1
1Active Not RecruitingTreatmentCancers / Metastatic Colorectal Cancer (MCRC) / Tumors, Solid1
1Active Not RecruitingTreatmentCancers / Neoplasms1
1Active Not RecruitingTreatmentCervical Carcinoma / Colorectal Adenocarcinoma / Non-Squamous Non-Small Cell Lung Cancer / Platinum-refractory Ovarian Carcinoma / Renal Cell Adenocarcinoma1
1Active Not RecruitingTreatmentColorectal Cancers2
1Active Not RecruitingTreatmentFallopian Tube Cancer / Ovarian Carcinoma / Primary Peritoneal Cancer1
1Active Not RecruitingTreatmentFallopian Tube Carcinosarcoma / Fallopian Tube Clear Cell Adenocarcinoma / Fallopian Tube Endometrioid Adenocarcinoma / Fallopian Tube Mucinous Adenocarcinoma / Fallopian Tube Serous Neoplasm / Fallopian Tube Transitional Cell Carcinoma / Fallopian Tube Undifferentiated Carcinoma / Ovarian Brenner Tumor / Ovarian Carcinosarcoma / Ovarian Clear Cell Adenocarcinoma / Ovarian Endometrioid Adenocarcinoma / Ovarian Mixed Epithelial Tumor / Ovarian Mucinous Adenocarcinoma / Ovarian Seromucinous Tumor / Ovarian Serous Adenocarcinoma / Ovarian Transitional Cell Carcinoma / Ovarian Undifferentiated Carcinoma / Primary Peritoneal Serous Adenocarcinoma / Stage IIA Fallopian Tube Cancer / Stage IIA Fallopian Tube Cancer AJCC v6 and v7 / Stage IIA Ovarian Cancer / Stage IIA Ovarian Cancer AJCC V6 and v7 / Stage IIB Fallopian Tube Cancer / Stage IIB Fallopian Tube Cancer AJCC v6 and v7 / Stage IIB Ovarian Cancer / Stage IIB Ovarian Cancer AJCC v6 and v7 / Stage IIC Fallopian Tube Cancer / Stage IIC Fallopian Tube Cancer AJCC v6 and v7 / Stage IIC Ovarian Cancer / Stage IIC Ovarian Cancer AJCC v6 and v7 / Stage IIIA Fallopian Tube Cancer / Stage IIIA Fallopian Tube Cancer AJCC v7 / Stage IIIA Ovarian Cancer / Stage IIIA Ovarian Cancer AJCC v6 and v7 / Stage IIIA Primary Peritoneal Cancer / Stage IIIA Primary Peritoneal Cancer AJCC v7 / Stage IIIB Fallopian Tube Cancer / Stage IIIB Fallopian Tube Cancer AJCC v7 / Stage IIIB Ovarian Cancer / Stage IIIB Ovarian Cancer AJCC v6 and v7 / Stage IIIB Primary Peritoneal Cancer / Stage IIIB Primary Peritoneal Cancer AJCC v7 / Stage IIIC Fallopian Tube Cancer / Stage IIIC Fallopian Tube Cancer AJCC v7 / Stage IIIC Ovarian Cancer / Stage IIIC Ovarian Cancer AJCC v6 and v7 / Stage IIIC Primary Peritoneal Cancer / Stage IIIC Primary Peritoneal Cancer AJCC v7 / Stage IV Fallopian Tube Cancer / Stage IV Fallopian Tube Cancer AJCC v6 and v7 / Stage IV Ovarian Cancer / Stage IV Ovarian Cancer AJCC v6 and v7 / Stage IV Primary Peritoneal Cancer / Stage IV Primary Peritoneal Cancer AJCC v7 / Undifferentiated Fallopian Tube Carcinoma / Undifferentiated Ovarian Carcinoma1
1Active Not RecruitingTreatmentGlioblastomas / Gliomas1
1Active Not RecruitingTreatmentKRAS Mutant Metastatic Colorectal Cancer1
1Active Not RecruitingTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)1
1Active Not RecruitingTreatmentMalignant Gliomas1
1Active Not RecruitingTreatmentMetastatic Colorectal Cancers1
1Active Not RecruitingTreatmentNeuroblastomas1
1Active Not RecruitingTreatmentSarcomas1
1Active Not RecruitingTreatmentSolid Cancers1
1Active Not RecruitingTreatmentTumors, Solid1
1CompletedNot AvailablePterygium1
1CompletedNot AvailableTumors, Solid3
1CompletedBasic ScienceHealthy Volunteers1
1CompletedBasic ScienceLung Cancer Non-Small Cell Cancer (NSCLC) / Lung Cancers1
1CompletedOtherRenal Cell Adenocarcinoma1
1CompletedTreatmentAdenocarcinoma of the Ovaries / Fallopian Tube Adenocarcinoma / Primary Peritoneal Carcinoma1
1CompletedTreatmentAdenocarcinoma of the Rectum / Stage II Rectal Cancer / Stage III Rectal Cancer1
1CompletedTreatmentAdenocarcinomas / Lung Cancer Non-Small Cell Cancer (NSCLC)1
1CompletedTreatmentAdult Grade III Lymphomatoid Granulomatosis / Adult Nasal Type Extranodal NK/T-Cell Lymphoma / Anaplastic Large Cell Lymphoma / Angioimmunoblastic T-Cell Lymphoma / Childhood Burkitt Lymphoma / Childhood Diffuse Large Cell Lymphoma / Childhood Grade III Lymphomatoid Granulomatosis / Childhood Immunoblastic Large Cell Lymphoma / Childhood Nasal Type Extranodal NK/T-cell Lymphoma / Cutaneous B-Cell Non-Hodgkin Lymphoma / Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue / Hepatosplenic T-Cell Lymphoma / Intraocular Lymphoma / Nodal marginal zone B-cell lymphomas / Noncutaneous Extranodal Lymphoma / Peripheral T-Cell Lymphoma (PTCL) / Progressive Hairy Cell Leukemia, Initial Treatment / Recurrent Adult Burkitt Lymphoma / Recurrent Adult Diffuse Large Cell Lymphoma / Recurrent Adult Diffuse Mixed Cell Lymphoma / Recurrent Adult Diffuse Small Cleaved Cell Lymphoma / Recurrent Adult Hodgkin's Lymphoma / Recurrent Adult Immunoblastic Large Cell Lymphoma / Recurrent Adult Lymphoblastic Lymphoma / Recurrent Adult T-Cell Leukemia/Lymphoma / Recurrent Childhood Anaplastic Large Cell Lymphoma / Recurrent Childhood Large Cell Lymphoma / Recurrent Childhood Lymphoblastic Lymphoma / Recurrent Childhood Small Noncleaved Cell Lymphoma / Recurrent Grade 1 Follicular Lymphoma / Recurrent Grade 2 Follicular Lymphoma / Recurrent Grade 3 Follicular Lymphoma / Recurrent Mantle Cell Lymphoma / Recurrent Mycosis Fungoides/Sezary Syndrome / Recurrent/Refractory Childhood Hodgkin Lymphoma / Refractory Hairy Cell Leukemia / Small Intestine Lymphoma / Splenic Marginal Zone Lymphoma / Stage IV Adult Burkitt Lymphoma / Stage IV Adult Diffuse Large Cell Lymphoma / Stage IV Adult Diffuse Mixed Cell Lymphoma / Stage IV Adult Diffuse Small Cleaved Cell Lymphoma / Stage IV Adult Hodgkin Lymphoma / Stage IV Adult Immunoblastic Large Cell Lymphoma / Stage IV Adult Lymphoblastic Lymphoma / Stage IV Adult T-Cell Leukemia/Lymphoma / Stage IV Childhood Anaplastic Large Cell Lymphoma / Stage IV Childhood Hodgkin Lymphoma / Stage IV Childhood Large Cell Lymphoma / Stage IV Childhood Lymphoblastic Lymphoma / Stage IV Childhood Small Noncleaved Cell Lymphoma / Stage IV Grade 1 Follicular Lymphoma / Stage IV Grade 2 Follicular Lymphoma / Stage IV Grade 3 Follicular Lymphoma / Stage IV Mantle Cell Lymphoma / Stage IVA Mycosis Fungoides/Sezary Syndrome / Stage IVB Mycosis Fungoides/Sezary Syndrome / T-Cell Large Granular Lymphocyte Leukemia / Testicular Lymphoma / Unspecified Adult Solid Tumor, Protocol Specific / Unspecified Childhood Solid Tumor, Protocol Specific / Waldenström's Macroglobulinemia (WM)1
1CompletedTreatmentAdult Solid Tumor1
1CompletedTreatmentAdvanced Cancers3
1CompletedTreatmentAdvanced Gastrointestinal Tumors1
1CompletedTreatmentAdvanced Malignancies / Refractory Malignancy1
1CompletedTreatmentAdvanced Malignancy / Malignant Lymphomas / Plasma Cell Myeloma / Tumors, Solid1
1CompletedTreatmentAdvanced Solid Tumors2
1CompletedTreatmentAdvanced Solid Tumors / Liver Cancer1
1CompletedTreatmentAnal, Colon, and Rectal Cancers / Colon/Rectal Cancer / Neoplasms, Colorectal1
1CompletedTreatmentAnaplastic Astrocytoma (AA) / Glioblastoma Multiforme (GBM)1
1CompletedTreatmentAstrocytoma, Oligoastrocytoma, Mixed / Ganglioglioma / Ganglioneuroma / Glioblastoma Multiforme Glioma / Gliomas1
1CompletedTreatmentBrenner Tumor / Fallopian Tube Cancer / Ovarian Carcinosarcoma / Ovarian Clear Cell Cystadenocarcinoma / Ovarian Endometrioid Adenocarcinoma / Ovarian Mixed Epithelial Carcinoma / Ovarian Mucinous Cystadenocarcinoma / Ovarian Serous Cystadenocarcinoma / Ovarian Undifferentiated Adenocarcinoma / Primary Peritoneal Cavity Cancer / Stage II Ovarian Epithelial Cancer / Stage III Ovarian Epithelial Cancer / Stage IV Ovarian Epithelial Cancer1
1CompletedTreatmentBrenner Tumor / Fallopian Tube Cancer / Ovarian Clear Cell Cystadenocarcinoma / Ovarian Endometrioid Adenocarcinoma / Ovarian Mixed Epithelial Carcinoma / Ovarian Mucinous Cystadenocarcinoma / Ovarian Serous Cystadenocarcinoma / Ovarian Undifferentiated Adenocarcinoma / Primary Peritoneal Cavity Cancer / Stage II Ovarian Epithelial Cancer / Stage III Ovarian Epithelial Cancer / Stage IV Ovarian Epithelial Cancer1
1CompletedTreatmentCancer of Parotid / Head and Neck Carcinoma / Malignant Neoplasm of Thyroid / Melanoma / Parotid Gland Cancer / Stage IV Head and Neck Cancer / Thyroid neoplasms malignant1
1CompletedTreatmentCancer of the Ovary1
1CompletedTreatmentCancer of the Ovary / Fallopian Tube Cancer / Primary Peritoneal Cancer1
1CompletedTreatmentCancer of the Ovary / Non-Squamous Non-Small Cell Lung Cancer1
1CompletedTreatmentCancer, Advanced3
1CompletedTreatmentCancer, Advanced / Liver Cancer1
1CompletedTreatmentCancer, Advanced / Metastatic Cancers1
1CompletedTreatmentCancer, Breast1
1CompletedTreatmentCancer, Breast / Metastatic Breast Cancer, Locally Advanced Breast Cancer1
1CompletedTreatmentCancer, Breast / Lymphedema of the extremities1
1CompletedTreatmentCancers1
1CompletedTreatmentCancers / Unspecified Adult Solid Tumor, Protocol Specific1
1CompletedTreatmentCentral nervous system neoplasms malignant NEC / Recurrent or Refractory Solid Tumors1
1CompletedTreatmentClear Cell Renal Cell Carcinoma / Renal Cell Cancer, Recurrent / Stage I Renal Cell Cancer / Stage II Renal Cell Cancer / Stage III Renal Cell Cancer / Stage IV Renal Cell Cancer / Unspecified Adult Solid Tumor, Protocol Specific1
1CompletedTreatmentColorectal Cancers5
1CompletedTreatmentCorneal Neovascularization1
1CompletedTreatmentGlioblastoma Multiforme (GBM)2
1CompletedTreatmentGlioblastomas1
1CompletedTreatmentHealthy Volunteers1
1CompletedTreatmentHemorrhagic Hereditary Telangiectasia (HHT)1
1CompletedTreatmentLeukemias / Refractory Solid Tumors1
1CompletedTreatmentLiver Cancer1
1CompletedTreatmentLocally Advanced Sarcoma / Metastatic Sarcoma / Sarcomas / Soft Tissue Sarcoma (STS) / Unresectable Sarcoma1
1CompletedTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)1
1CompletedTreatmentLung Cancers1
1CompletedTreatmentLung Cancers / Lymphoproliferative Disorders / Malignant Lymphomas / Small Intestine Cancer / Unspecified Adult Solid Tumor, Protocol Specific1
1CompletedTreatmentMalignant Neoplasm of Pancreas4
1CompletedTreatmentMalignant Ovarian Mixed Epithelial Tumor / Ovarian Clear Cell Cystadenocarcinoma / Ovarian Endometrioid Adenocarcinoma / Ovarian Seromucinous Carcinoma / Ovarian Serous Cystadenocarcinoma / Recurrent Fallopian Tube Carcinoma / Recurrent Ovarian Carcinoma / Recurrent Primary Peritoneal Carcinoma / Undifferentiated Ovarian Carcinoma1
1CompletedTreatmentMalignant Peritoneal Neoplasm1
1CompletedTreatmentMetastatic Colon Cancer / Recurrent Colon Cancer / Recurrent Rectal Cancer / Stage IV Rectal Cancer1
1CompletedTreatmentMetastatic Colorectal Cancers5
1CompletedTreatmentMetastatic Colorectal Cancers / Tumors, Solid1
1CompletedTreatmentMetastatic Malignant Neoplasm to Brain1
1CompletedTreatmentMetastatic Renal Cell Carcinoma / Renal Cancers1
1CompletedTreatmentMetastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma / Recurrent Adenoid Cystic Carcinoma of the Oral Cavity / Recurrent Basal Cell Carcinoma of the Lip / Recurrent Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity / Recurrent Inverted Papilloma of the Paranasal Sinus and Nasal Cavity / Recurrent Lymphoepithelioma of the Nasopharynx / Recurrent Lymphoepithelioma of the Oropharynx / Recurrent Metastatic Squamous Neck Cancer With Occult Primary / Recurrent Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity / Recurrent Mucoepidermoid Carcinoma of the Oral Cavity / Recurrent Salivary Gland Cancer / Recurrent Squamous Cell Carcinoma of the Hypopharynx / Recurrent Squamous Cell Carcinoma of the Larynx / Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity / Recurrent Squamous Cell Carcinoma of the Nasopharynx / Recurrent Squamous Cell Carcinoma of the Oropharynx / Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity / Recurrent Verrucous Carcinoma of the Larynx / Recurrent Verrucous Carcinoma of the Oral Cavity / Stage III Adenoid Cystic Carcinoma of the Oral Cavity / Stage III Basal Cell Carcinoma of the Lip / Stage III Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity / Stage III Inverted Papilloma of the Paranasal Sinus and Nasal Cavity / Stage III Lymphoepithelioma of the Nasopharynx / Stage III Lymphoepithelioma of the Oropharynx / Stage III Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity / Stage III Mucoepidermoid Carcinoma of the Oral Cavity / Stage III Salivary Gland Cancer / Stage III Squamous Cell Carcinoma of the Hypopharynx / Stage III Squamous Cell Carcinoma of the Larynx / Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity / Stage III Squamous Cell Carcinoma of the Nasopharynx / Stage III Squamous Cell Carcinoma of the Oropharynx / Stage III Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity / Stage III Verrucous Carcinoma of the Larynx / Stage III Verrucous Carcinoma of the Oral Cavity / Stage IV Adenoid Cystic Carcinoma of the Oral Cavity / Stage IV Basal Cell Carcinoma of the Lip / Stage IV Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity / Stage IV Inverted Papilloma of the Paranasal Sinus and Nasal Cavity / Stage IV Lymphoepithelioma of the Nasopharynx / Stage IV Lymphoepithelioma of the Oropharynx / Stage IV Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity / Stage IV Mucoepidermoid Carcinoma of the Oral Cavity / Stage IV Salivary Gland Cancer / Stage IV Squamous Cell Carcinoma of the Hypopharynx / Stage IV Squamous Cell Carcinoma of the Larynx / Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity / Stage IV Squamous Cell Carcinoma of the Nasopharynx / Stage IV Squamous Cell Carcinoma of the Oropharynx / Stage IV Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity / Stage IV Verrucous Carcinoma of the Larynx / Stage IV Verrucous Carcinoma of the Oral Cavity / Untreated Metastatic Squamous Neck Cancer With Occult Primary1
1CompletedTreatmentMucinous Adenocarcinoma of the Colon / Mucinous Adenocarcinoma of the Rectum / Recurrent Colon Cancer / Recurrent Rectal Cancer / Signet Ring Adenocarcinoma of the Colon / Signet Ring Adenocarcinoma of the Rectum / Stage IIIA Colon Cancer / Stage IIIA Rectal Cancer / Stage IIIB Colon Cancer / Stage IIIB Rectal Cancer / Stage IIIC Colon Cancer / Stage IIIC Rectal Cancer / Stage IVA Colon Cancer / Stage IVA Rectal Cancer / Stage IVB Colon Cancer / Stage IVB Rectal Cancer1
1CompletedTreatmentMyopia1
1CompletedTreatmentMyopia, Degenerative / Pathological Myopia / Subfoveal Choroidal Neovascularization1
1CompletedTreatmentNeoplasms3
1CompletedTreatmentNeoplasms Metastasis1
1CompletedTreatmentNeoplasms, Malignant1
1CompletedTreatmentNeovascular Age-Related Macular Degeneration1
1CompletedTreatmentNeuroblastomas1
1CompletedTreatmentNeuromyelitis Optica / Neuromyelitis Optica Spectrum Disorder1
1CompletedTreatmentNon-Squamous Non-Small Cell Lung Cancer3
1CompletedTreatmentRectal Carcinoma1
1CompletedTreatmentRecurrent Colon Carcinoma / Recurrent Rectal Carcinoma / Stage IVA Colon Cancer / Stage IVA Rectal Cancer / Stage IVB Colon Cancer / Stage IVB Rectal Cancer1
1CompletedTreatmentRecurrent Respiratory Papillomatosis1
1CompletedTreatmentRefractory Solid Tumors in Children1
1CompletedTreatmentRenal Cell Adenocarcinoma2
1CompletedTreatmentSarcomas1
1CompletedTreatmentSolid Cancers6
1CompletedTreatmentSolid Neoplasms1
1CompletedTreatmentTumors1
1CompletedTreatmentTumors, Central Nervous System1
1CompletedTreatmentTumors, Solid4
1CompletedTreatmentUnresectable Advanced Cancer1
1CompletedTreatmentUnspecified Adult Solid Tumor1
1CompletedTreatmentUnspecified Adult Solid Tumor, Protocol Specific5
1CompletedTreatmentUnspecified Childhood Solid Tumor, Protocol Specific1
1Not Yet RecruitingTreatmentCancer of the Ovary1
1Not Yet RecruitingTreatmentGlioblastomas1
1Not Yet RecruitingTreatmentHealthy Volunteers1
1Not Yet RecruitingTreatmentLiver Cancer1
1Not Yet RecruitingTreatmentMetastatic Colorectal Cancers1
1RecruitingDiagnosticRecurrent Glioblastoma1
1RecruitingOtherHealthy Volunteers1
1RecruitingScreeningHealthy Volunteers1
1RecruitingTreatmentAdvanced Cancers / Advanced Malignant Neoplasm / Castleman's Disease / Digestive System Carcinoma / Erdheim-Chester Disease (ECD) / Lip and Oral Cavity Carcinoma / Lymphangioleiomyomatosis / Malignant Endocrine Neoplasm / Malignant Female Reproductive System Neoplasm / Malignant Male Reproductive System Neoplasm / Malignant respiratory tract neoplasm / Malignant Thoracic Neoplasm / Malignant Urinary System Neoplasm / Mesothelial Neoplasm / Metastatic Malignant Neoplasm / Neoplasms, Malignant / Neurofibromatosis Type 2 / Recurrent Adult Soft Tissue Sarcoma / Recurrent Breast Carcinoma / Recurrent Childhood Soft Tissue Sarcoma / Recurrent Digestive System Carcinoma / Recurrent Female Reproductive System Carcinoma / Recurrent Male Reproductive System Carcinoma / Recurrent Malignant Neoplasm / Recurrent Pharyngeal Carcinoma / Recurrent Thyroid Gland Carcinoma / Refractory Malignant Neoplasm / Soft Tissue Neoplasms / Stage III Breast Cancer AJCC V7 / Stage III Pharyngeal Cancer / Stage IIIA Breast Cancer AJCC v7 / Stage IIIB Breast Cancer AJCC v7 / Stage IIIC Breast Cancer AJCC v7 / Stage IV Breast Cancer AJCC v6 and v7 / Stage IV Pharyngeal Cancer / Stage IVA Pharyngeal Cancer / Stage IVB Pharyngeal Cancer / Stage IVC Pharyngeal Cancer / Thyroid Gland Neoplasm / Urothelial carcinoma ureter metastatic1
1RecruitingTreatmentAdvanced/Metastatic Solid Tumors1
1RecruitingTreatmentBrain Arteriovenous Malformations1
1RecruitingTreatmentCancer, Advanced / Metastatic Cancers / Tumors, Solid1
1RecruitingTreatmentCarcinoma NOS1
1RecruitingTreatmentCarcinoma, Colorectal / Colorectal Cancers / Colorectal Tumors / Neoplasms, Colorectal1
1RecruitingTreatmentColorectal Cancers / Glioblastoma Multiforme (GBM) / Gliosarcoma / Renal Cell Adenocarcinoma1
1RecruitingTreatmentEndometrial Cancers / Fallopian Tube Cancer / Ovarian Epithelial Cancer / Primary Peritoneal Cancer1
1RecruitingTreatmentGlioblastoma Multiforme (GBM)1
1RecruitingTreatmentGlioblastomas1
1RecruitingTreatmentGlioblastomas / Malignant Gliomas1
1RecruitingTreatmentHealthy Male Subjects1
1RecruitingTreatmentHealthy Volunteers2
1RecruitingTreatmentHepatocellular,Carcinoma1
1RecruitingTreatmentHigh Grade Glioma (HGG)1
1RecruitingTreatmentInflammatory carcinoma of the breast1
1RecruitingTreatmentMetastatic Colorectal Cancers1
1RecruitingTreatmentNeoplasms, Brain1
1RecruitingTreatmentRenal Cell Adenocarcinoma1
1RecruitingTreatmentRetinopathy of Prematurity1
1RecruitingTreatmentTumors, Solid1
1RecruitingTreatmentWet Age-Related Macular Degeneration1
1SuspendedTreatmentAdenosquamous carcinoma of the cervix / Cervical Adenosarcoma / Cervical Carcinosarcoma / Cervical Squamous Cell Carcinoma, Not Otherwise Specified / Endometrial Clear Cell Adenocarcinoma / Endometrial Endometrioid Adenocarcinoma / Endometrial Mixed Adenocarcinoma / Endometrial Mucinous Adenocarcinoma / Endometrial Squamous Cell Carcinoma / Endometrial Transitional Cell Carcinoma / Endometrial Undifferentiated Carcinoma / Fallopian Tube Adenocarcinoma / Fallopian Tube Clear Cell Adenocarcinoma / Fallopian Tube Mucinous Adenocarcinoma / Fallopian Tube Serous Adenocarcinoma / Fallopian Tube Transitional Cell Carcinoma / Malignant Ovarian Epithelial Tumor / Malignant Peritoneal Neoplasm / Ovarian Carcinosarcoma / Ovarian Clear Cell Adenocarcinoma / Ovarian Endometrioid Adenocarcinoma / Ovarian Mucinous Adenocarcinoma / Ovarian Serous Adenocarcinoma / Ovarian Transitional Cell Carcinoma / Primary Peritoneal Serous Adenocarcinoma / Recurrent Fallopian Tube Carcinoma / Recurrent Melanoma / Recurrent Ovarian Carcinoma / Recurrent Primary Peritoneal Carcinoma / Stage IV Skin Melanoma / Undifferentiated Fallopian Tube Carcinoma / Undifferentiated Ovarian Carcinoma / Uterine Corpus Carcinosarcoma1
1SuspendedTreatmentMalignant Gliomas1
1SuspendedTreatmentVestibular Schwannomas1
1TerminatedTreatmentAdenocarcinoma of the Lung / Bronchoalveolar Cell Lung Cancer / Large Cell Lung Cancer / Stage II Non-Small Cell Lung Cancer / Stage IIIA Non-Small Cell Lung Cancer / Stage IIIb Non-small Cell Lung Cancer1
1TerminatedTreatmentAdvanced Colorectal Cancer1
1TerminatedTreatmentAnaplastic Astrocytoma (AA) / Anaplastic Oligodendroglioma (AO) / High Grade Glioma: Glioblastoma (GBM) / High Grade Glioma: Gliosarcoma / Mixed Anaplastic Oligoastrocytoma (AOA)1
1TerminatedTreatmentCancer of the Ovary / Fallopian Tube Carcinoma / Ovarian Epithelial Cancer / Primary Peritoneal Carcinoma1
1TerminatedTreatmentCancer, Breast / Pleural Effusion, Malignant1
1TerminatedTreatmentCholangiocarcinomas / Hepatocellular,Carcinoma / Liver Cancer1
1TerminatedTreatmentColorectal Cancers / Unspecified Adult Solid Tumor, Protocol Specific1
1TerminatedTreatmentGlioblastoma Multiforme (GBM)1
1TerminatedTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)1
1TerminatedTreatmentMalignant Glioma (WHO Grade III or IV)1
1TerminatedTreatmentMetastatic Colorectal Cancers1
1TerminatedTreatmentNeoplasms1
1TerminatedTreatmentRetinopathy of Prematurity1
1TerminatedTreatmentToxicity1
1TerminatedTreatmentUnspecified Adult Solid Tumor, Protocol Specific1
1Unknown StatusTreatmentDiffuse Diabetic Macular Edema1
1Unknown StatusTreatmentIntravitreal Bevacizumab Injection / Pars Plana Vitrectomy / Retinopathy, Diabetic / Tractional Retinal Detachment1
1Unknown StatusTreatmentRefractory Malignant Ascites1
1Unknown StatusTreatmentLymphedema of the extremities1
1WithdrawnNot AvailableNeovascular Age-Related Macular Degeneration1
1WithdrawnOtherHealthy Volunteers1
1WithdrawnTreatmentGlioblastoma Multiforme (GBM)1
1WithdrawnTreatmentTumors, Central Nervous System1
1, 2Active Not RecruitingTreatmentAdvanced Gastrointestinal Cancers1
1, 2Active Not RecruitingTreatmentCancer of the Ovary1
1, 2Active Not RecruitingTreatmentClear Cell Renal Cell Carcinoma1
1, 2Active Not RecruitingTreatmentCorneal Graft Failure / Corneal Neovascularization1
1, 2Active Not RecruitingTreatmentGlioblastoma Multiforme (GBM)3
1, 2Active Not RecruitingTreatmentGlioblastoma Multiforme (GBM) / Gliomas / Gliosarcoma / Malignant Brain Tumors1
1, 2Active Not RecruitingTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)1
1, 2Active Not RecruitingTreatmentMalignant Gliomas1
1, 2Active Not RecruitingTreatmentMalignant Neoplasm of Pancreas2
1, 2Active Not RecruitingTreatmentMetastatic Pancreas Adenocarcinoma1
1, 2Active Not RecruitingTreatmentNon-Small Cell Lung Carcinoma (NSCLC)1
1, 2Active Not RecruitingTreatmentPulmonary Veno Occlusive Disease1
1, 2Active Not RecruitingTreatmentRecurrent Gliomas1
1, 2Active Not RecruitingTreatmentRenal Cell Adenocarcinoma1
1, 2CompletedBasic ScienceAge-Related Macular Degeneration (ARMD) / Diabetic Macular Edema (DME) / Retinal Vein Occlusions(RVO)1
1, 2CompletedTreatmentAdenocarcinoma of the Rectum / Rectal Carcinoma1
1, 2CompletedTreatmentAdenocarcinomas / Malignant Neoplasm of Colon / Metastasis / Rectal Carcinoma1
1, 2CompletedTreatmentAdult Anaplastic Astrocytoma / Adult Anaplastic Oligodendroglioma / Adult Giant Cell Glioblastoma / Adult Glioblastoma / Adult Gliosarcoma / Adult Mixed Glioma / Recurrent Adult Brain Neoplasm1
1, 2CompletedTreatmentAdult Brain Glioblastoma / Glioblastoma Multiforme (GBM)1
1, 2CompletedTreatmentBrain Cancer / Malignant Gliomas / Recurrent Glioblastoma1
1, 2CompletedTreatmentCancer, Breast3
1, 2CompletedTreatmentCentral Nervous System Neoplasms / Neoplasms, Brain1
1, 2CompletedTreatmentChromophobe Renal Cell Carcinoma / Clear Cell Renal Cell Carcinoma / Papillary Renal Cell Carcinoma / Renal Cell Carcinoma Recurrent / Sarcomatoid Renal Cell Carcinoma / Stage IV Renal Cell Cancer1
1, 2CompletedTreatmentClear Cell Renal Cell Carcinoma1
1, 2CompletedTreatmentClear Cell Renal Cell Carcinoma / Renal Cell Cancer, Recurrent / Stage III Renal Cell Cancer / Stage IV Renal Cell Cancer1
1, 2CompletedTreatmentClear Cell Renal Cell Carcinoma / Renal Cell Cancer, Recurrent / Stage IV Renal Cell Cancer1
1, 2CompletedTreatmentColon Cancer With Metastases to the Liver1
1, 2CompletedTreatmentColorectal Cancers3
1, 2CompletedTreatmentColorectal Cancers / Malignant Neoplasm of Colon / Metastatic Colorectal Cancers / Rectal Carcinoma1
1, 2CompletedTreatmentCorneal Graft Failure / Corneal Neovascularization1
1, 2CompletedTreatmentGlioblastomas / Neoplasms, Brain1
1, 2CompletedTreatmentLeptomeningeal Metastases1
1, 2CompletedTreatmentLeukemias / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Neoplasms1
1, 2CompletedTreatmentLiver Cancer1
1, 2CompletedTreatmentLocally Advanced Gastric Carcinoma1
1, 2CompletedTreatmentLung Cancers2
1, 2CompletedTreatmentMale Breast Cancer / Stage IIIB Breast Cancer / Stage IIIC Breast Cancer / Stage IV Breast Cancer1
1, 2CompletedTreatmentMalignant Gliomas1
1, 2CompletedTreatmentMetastatic Colon Cancer / Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma / Non-Small Cell Lung Cancer Recurrent / Recurrent Adenoid Cystic Carcinoma of the Oral Cavity / Recurrent Basal Cell Carcinoma of the Lip / Recurrent Colon Cancer / Recurrent Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity / Recurrent Inverted Papilloma of the Paranasal Sinus and Nasal Cavity / Recurrent Lymphoepithelioma of the Nasopharynx / Recurrent Lymphoepithelioma of the Oropharynx / Recurrent Metastatic Squamous Neck Cancer With Occult Primary / Recurrent Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity / Recurrent Mucoepidermoid Carcinoma of the Oral Cavity / Recurrent Pancreatic Cancer / Recurrent Rectal Cancer / Recurrent Salivary Gland Cancer / Recurrent Squamous Cell Carcinoma of the Hypopharynx / Recurrent Squamous Cell Carcinoma of the Larynx / Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity / Recurrent Squamous Cell Carcinoma of the Nasopharynx / Recurrent Squamous Cell Carcinoma of the Oropharynx / Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity / Recurrent Verrucous Carcinoma of the Larynx / Recurrent Verrucous Carcinoma of the Oral Cavity / Stage III Adenoid Cystic Carcinoma of the Oral Cavity / Stage III Basal Cell Carcinoma of the Lip / Stage III Colon Cancer / Stage III Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity / Stage III Inverted Papilloma of the Paranasal Sinus and Nasal Cavity / Stage III Lymphoepithelioma of the Nasopharynx / Stage III Lymphoepithelioma of the Oropharynx / Stage III Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity / Stage III Mucoepidermoid Carcinoma of the Oral Cavity / Stage III Pancreatic Cancer / Stage III Rectal Cancer / Stage III Salivary Gland Cancer / Stage III Squamous Cell Carcinoma of the Hypopharynx / Stage III Squamous Cell Carcinoma of the Larynx / Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity / Stage III Squamous Cell Carcinoma of the Nasopharynx / Stage III Squamous Cell Carcinoma of the Oropharynx / Stage III Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity / Stage III Verrucous Carcinoma of the Larynx / Stage III Verrucous Carcinoma of the Oral Cavity / Stage IIIb Non-small Cell Lung Cancer / Stage IV Adenoid Cystic Carcinoma of the Oral Cavity / Stage IV Basal Cell Carcinoma of the Lip / Stage IV Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity / Stage IV Inverted Papilloma of the Paranasal Sinus and Nasal Cavity / Stage IV Lymphoepithelioma of the Nasopharynx / Stage IV Lymphoepithelioma of the Oropharynx / Stage IV Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity / Stage IV Mucoepidermoid Carcinoma of the Oral Cavity / Stage IV Non-Small Cell Lung Cancer / Stage IV Pancreatic Cancer / Stage IV Rectal Cancer / Stage IV Renal Cell Cancer / Stage IV Salivary Gland Cancer / Stage IV Squamous Cell Carcinoma of the Hypopharynx / Stage IV Squamous Cell Carcinoma of the Larynx / Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity / Stage IV Squamous Cell Carcinoma of the Nasopharynx / Stage IV Squamous Cell Carcinoma of the Oropharynx / Stage IV Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity / Stage IV Verrucous Carcinoma of the Larynx / Stage IV Verrucous Carcinoma of the Oral Cavity / Untreated Metastatic Squamous Neck Cancer With Occult Primary1
1, 2CompletedTreatmentMetastatic Colorectal Cancers1
1, 2CompletedTreatmentMetastatic Melanoma1
1, 2CompletedTreatmentNeoplasms, Colorectal1
1, 2CompletedTreatmentProstate Cancer2
1, 2CompletedTreatmentRecurrent Melanoma / Stage III Melanoma / Stage IV Melanoma / Unspecified Adult Solid Tumor, Protocol Specific1
1, 2CompletedTreatmentRecurrent Squamous Cell Carcinoma of the Hypopharynx / Recurrent Squamous Cell Carcinoma of the Larynx / Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity / Recurrent Squamous Cell Carcinoma of the Nasopharynx / Recurrent Squamous Cell Carcinoma of the Oropharynx / Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity / Salivary Gland Squamous Cell Carcinoma / Stage IV Squamous Cell Carcinoma of the Hypopharynx / Stage IV Squamous Cell Carcinoma of the Larynx / Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity / Stage IV Squamous Cell Carcinoma of the Nasopharynx / Stage IV Squamous Cell Carcinoma of the Oropharynx / Stage IV Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity1
1, 2CompletedTreatmentRetinopathy, Diabetic / Vitreous Hemorrhage1
1, 2CompletedTreatmentStage IV Colorectal Cancer1
1, 2Enrolling by InvitationTreatmentTumors, Solid1
1, 2Not Yet RecruitingTreatmentAdvanced Colorectal Cancer1
1, 2Not Yet RecruitingTreatmentCancer of Colon / Cancer of Liver / Cancer of Pancreas / Cancer of Rectum / Cancer, Gall Bladder / Glioblastoma Multiforme (GBM) / Myeloma Multiple1
1, 2Not Yet RecruitingTreatmentCancer of the Ovary1
1, 2Not Yet RecruitingTreatmentColorectal Cancers1
1, 2Not Yet RecruitingTreatmentGlioblastomas / Gliomas1
1, 2Not Yet RecruitingTreatmentHead and Neck Squamous Cell Carcinoma (HNSCC)1
1, 2Not Yet RecruitingTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)1
1, 2Not Yet RecruitingTreatmentMelanoma1
1, 2Not Yet RecruitingTreatmentNeuroendocrine Carcinoma of the Skin1
1, 2Not Yet RecruitingTreatmentNon Hodgkin Lymphoma (NHL)1
1, 2Not Yet RecruitingTreatmentTransitional Cell Carcinoma1
1, 2Not Yet RecruitingTreatmentTriple Negative Breast Cancer (TNBC)1
1, 2RecruitingTreatmentAdenocarcinoma of the Pancreas1
1, 2RecruitingTreatmentAdenocarcinoma of the Pancreas / Colorectal Adenocarcinoma / Metastatic Colorectal Cancers / Pancreatic Cancer Metastatic1
1, 2RecruitingTreatmentAdvanced (Stage IIIB-C-IV) Ovarian, Primary Peritoneal and Fallopian Tube Cancer1
1, 2RecruitingTreatmentAnaplastic Astrocytoma (AA) / Brain Stem Gliomas / Diffuse Intrinsic Pontine Glioma (DIPG) / DIPG / Glioblastoma Multiforme (GBM) / Glioma, Astrocytic / Gliosarcoma / Low-Grade Gliomas / Optic Nerve Glioma / Pilocytic Astrocytoma / Pilomyxoid Astrocytoma / Pleomorphic Xanthoastrocytoma1
1, 2RecruitingTreatmentAnaplastic Astrocytoma (AA) / Brain Stem Gliomas / Diffuse Intrinsic Pontine Glioma (DIPG) / Fibrillary Astrocytoma of Brain / Glioblastoma Multiforme (GBM) / Glioma of Brainstem / Mixed Oligodendroglioma-Astrocytoma / Pilomyxoid Astrocytoma1
1, 2RecruitingTreatmentAnaplastic Astrocytoma (AA) / Glioblastoma Multiforme (GBM)1
1, 2RecruitingTreatmentBreast / Lung Cancer Small Cell Lung Cancer (SCLC) / Malignant Neoplasm of Stomach / Ovarian1
1, 2RecruitingTreatmentClear Cell Renal Cell Carcinoma / Stage IV Renal Cell Cancer1
1, 2RecruitingTreatmentColorectal Cancers1
1, 2RecruitingTreatmentEGFR-mutant Lung Cancers / Lung Cancer Non-Small Cell Cancer (NSCLC)1
1, 2RecruitingTreatmentGerm Cell Tumors1
1, 2RecruitingTreatmentGlioblastoma Multiforme (GBM)1
1, 2RecruitingTreatmentGlioblastoma Multiforme (GBM) / Neoplasms, Brain1
1, 2RecruitingTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)1
1, 2RecruitingTreatmentMalignant Neoplasm of Pancreas2
1, 2RecruitingTreatmentMalignant Solid Tumours1
1, 2RecruitingTreatmentMetastatic Cancers / Renal Cancers1
1, 2RecruitingTreatmentNeoplasms, Breast1
1, 2RecruitingTreatmentNeoplasms, Colorectal1
1, 2RecruitingTreatmentRenal Cell Adenocarcinoma1
1, 2RecruitingTreatmentSquamous Cell Carcinoma (SCC)1
1, 2RecruitingTreatmentTriple Negative Breast Cancer (TNBC)2
1, 2SuspendedTreatmentAnaplastic Astrocytoma (AA) / Glioblastoma Multiforme (GBM)1
1, 2TerminatedOtherLung Cancer Non-Small Cell Cancer (NSCLC)1
1, 2TerminatedTreatmentAdult Anaplastic Astrocytoma / Adult Anaplastic Oligodendroglioma / Adult Giant Cell Glioblastoma / Adult Glioblastoma / Adult Gliosarcoma / Recurrent Adult Brain Tumor1
1, 2TerminatedTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)1
1, 2TerminatedTreatmentLung Cancers1
1, 2TerminatedTreatmentMalignant Neoplasm of Pancreas1
1, 2TerminatedTreatmentMalignant Neoplasm of Pancreas / Pancreatic Ductal Adenocarcinoma1
1, 2TerminatedTreatmentMesothelioma1
1, 2TerminatedTreatmentMetastatic Colorectal Carcinoma1
1, 2TerminatedTreatmentProstate Cancer1
1, 2TerminatedTreatmentRenal Cell Adenocarcinoma / Renal Cell Cancer, Recurrent / Stage III Renal Cell Cancer / Stage IV Renal Cell Cancer1
1, 2Unknown StatusTreatmentAcute Nonarteritic Anterior Ischemic Optic Neuropathy1
1, 2Unknown StatusTreatmentAdvanced Gastric Cancer1
1, 2Unknown StatusTreatmentHereditary Haemorrhagic Telangiectasia (HHT)1
1, 2Unknown StatusTreatmentMacular Degeneration1
1, 2Unknown StatusTreatmentMelanoma (Skin)1
1, 2Unknown StatusTreatmentRenal Cell Adenocarcinoma1
1, 2WithdrawnNot AvailableCancer of the Ovary / Primary Peritoneal Cancer1
1, 2WithdrawnTreatmentGlioblastoma Multiforme (GBM)1
1, 2WithdrawnTreatmentLung Cancers1
1, 2WithdrawnTreatmentMetastatic Brain Tumors / Metastatic Melanoma1
2Active Not RecruitingNot AvailableAdenocarcinoma of the Gastro-oesophageal Junction / Metastatic Gastric Cancers1
2Active Not RecruitingBasic ScienceStage II Breast Cancer / Stage IIIA Breast Cancer / Stage IIIB Breast Cancer / Stage IIIC Breast Cancer1
2Active Not RecruitingOtherLung Cancer Non-Small Cell Cancer (NSCLC)1
2Active Not RecruitingTreatmentAcoustic Schwannoma / Adult Anaplastic Meningioma / Adult Ependymoma / Adult Grade I Meningioma / Adult Grade II Meningioma / Adult Meningeal Hemangiopericytoma / Adult Papillary Meningioma / Neurofibromatosis Type 1 / Neurofibromatosis Type 2 / Recurrent Adult Brain Tumor1
2Active Not RecruitingTreatmentAdenocarcinoma of the Cervix / Adenosquamous carcinoma of the cervix / Cervical Squamous Cell Carcinoma, Not Otherwise Specified / Recurrent Cervical Carcinoma / Recurrent, IV-B Cervical cancer / Stage IV Cervical Cancer AJCC v6 and v7 / Stage IVA Cervical Cancer / Stage IVA Cervical Cancer AJCC v6 and v7 / Stage IVB Cervical Cancer / Stage IVB Cervical Cancer AJCC v6 and v71
2Active Not RecruitingTreatmentAdenocarcinoma of the Lung / Adenosquamous Cell Lung Cancer / Adenosquamous Lung Carcinoma / Bronchoalveolar Cell Lung Cancer / Large Cell Lung Cancer / Large Cell Lung Carcinoma / Minimally Invasive Lung Adenocarcinoma / Squamous Cell Carcinoma of Lung / Squamous Cell Lung Carcinoma / Stage IIIA Non-Small Cell Lung Cancer / Stage IIIA Non-Small Cell Lung Cancer AJCC v7 / Stage IIIb Non-small Cell Lung Cancer / Stage IIIB Non-Small Cell Lung Cancer AJCC v71
2Active Not RecruitingTreatmentAdenocarcinoma of the Lung / Lung Cancer Non-Small Cell Cancer (NSCLC)1
2Active Not RecruitingTreatmentAdult Anaplastic Astrocytoma / Adult Anaplastic Ependymoma / Adult Anaplastic Oligodendroglioma / Adult Giant Cell Glioblastoma / Adult Glioblastoma1
2Active Not RecruitingTreatmentAdult Anaplastic Oligodendroglioma / Adult Giant Cell Glioblastoma / Adult Glioblastoma / Adult Gliosarcoma / Adult Oligodendroglioma / Giant Cell Glioblastoma / Glioblastomas / Gliosarcoma / Oligodendrogliomas / Recurrent Adult Brain Neoplasm / Recurrent Brain Neoplasm / Recurrent Glioblastoma1
2Active Not RecruitingTreatmentAdult Giant Cell Glioblastoma / Adult Glioblastoma / Adult Gliosarcoma / Recurrent Adult Brain Tumor1
2Active Not RecruitingTreatmentAdvanced Colorectal Cancer1
2Active Not RecruitingTreatmentAdvanced Gastric Cancer1
2Active Not RecruitingTreatmentAdvanced Ovarian Carcinoma / Ovarian Carcinosarcoma / Primary Peritoneal Carcinoma1
2Active Not RecruitingTreatmentAdvanced Solid Tumors / Carcinoids / Colorectal Cancers / Locally Advanced / Lung Cancer Non-Small Cell Cancer (NSCLC) / Malignant Lymphomas / Metastatic Cancers / Sarcomas / Tumors, Solid1
2Active Not RecruitingTreatmentAnaplastic Astrocytoma (AA) / Brain Stem Gliomas / Glial Cell Tumors / Glioblastoma Multiforme (GBM) / Gliomatosis Cerebri / Gliosarcoma / Malignant Gliomas1
2Active Not RecruitingTreatmentBrain and Central Nervous System Tumors3
2Active Not RecruitingTreatmentCancer of the Breast / Cancer, Breast / Neoplasms, Breast1
2Active Not RecruitingTreatmentCancer of the Ovary2
2Active Not RecruitingTreatmentCancer of the Ovary / Fallopian Tube Cancer / Malignant Peritoneal Neoplasm1
2Active Not RecruitingTreatmentCancer of the Ovary / Fallopian Tube Cancer / Primary Peritoneal Cavity Cancer / Recurrent Fallopian Tube Carcinoma / Recurrent Ovarian Carcinoma / Recurrent Primary Peritoneal Carcinoma1
2Active Not RecruitingTreatmentCancer, Breast7
2Active Not RecruitingTreatmentCancer, Breast / HER2-Negative Breast Cancer / Her2-Positive Breast Cancer / Recurrent Breast Cancer / Stage IA Breast Cancer / Stage IB Breast Cancer / Stage II Breast Cancer / Stage IIIA Breast Cancer / Stage IIIB Breast Cancer / Stage IIIC Breast Cancer1
2Active Not RecruitingTreatmentCervical Cancer, Cancer, Metastatic Cancers / Cervical Cancers1
2Active Not RecruitingTreatmentChoriocarcinoma / Epithelioid Trophoblastic Tumor / Gestational Trophoblastic Neoplasia / Placental Site Trophoblastic Tumor1
2Active Not RecruitingTreatmentClear Cell Renal Cell Carcinoma / Renal Cell Cancer, Recurrent / Renal Cell Carcinoma Recurrent / Stage IV Renal Cell Cancer / Stage IV Renal Cell Cancer AJCC V71
2Active Not RecruitingTreatmentColorectal Adenocarcinoma / KRAS wt Allele / Metastatic Colorectal Cancers / NRAS wt Allele / RAS Wild Type / Stage IV Colorectal Cancer / Stage IV Colorectal Cancer AJCC v7 / Stage IVA Colorectal Cancer / Stage IVA Colorectal Cancer AJCC v7 / Stage IVB Colorectal Cancer / Stage IVB Colorectal Cancer AJCC v71
2Active Not RecruitingTreatmentColorectal Cancer Liver Metastases1
2Active Not RecruitingTreatmentColorectal Cancers2
2Active Not RecruitingTreatmentDesmoplastic Small Round Cell Tumor (DSRCT) / Ewing Sarcoma of Bone or Soft Tissue / Localized Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor / Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor1
2Active Not RecruitingTreatmentEGFR Activating Mutation / EGFR Exon 19 Deletion Mutation / EGFR NP_005219.2:p.L858R / Non-Squamous Non-Small Cell Lung Carcinoma / Stage IV Non-Small Cell Lung Cancer / Stage IV Non-Small Cell Lung Cancer AJCC v71
2Active Not RecruitingTreatmentEndometrial Adenocarcinomas / Endometrial Adenosquamous Carcinoma / Endometrial Clear Cell Adenocarcinoma / Endometrial Serous Adenocarcinoma / Recurrent Uterine Corpus Carcinoma / Stage IIIA Uterine Corpus Cancer / Stage IIIB Uterine Corpus Cancer / Stage IIIC Uterine Corpus Cancer / Stage IVA Uterine Corpus Cancer / Stage IVB Uterine Corpus Cancer1
2Active Not RecruitingTreatmentEsophageal Cancers / Malignant Neoplasm of Stomach3
2Active Not RecruitingTreatmentEstrogen Receptor Negative / HER2/Neu Negative / Male Breast Carcinoma / Progesterone Receptor Negative / Stage IIA Breast Cancer / Stage IIB Breast Cancer / Stage IIIA Breast Cancer / Triple-Negative Breast Carcinoma1
2Active Not RecruitingTreatmentEstrogen Receptor-negative Breast Cancer / HER2-Negative Breast Cancer / Progesterone Receptor-negative Breast Cancer / Recurrent Breast Cancer / Stage IV Breast Cancer / Triple-Negative Breast Cancer (TNBC)1
2Active Not RecruitingTreatmentFallopian Tube Cancer / Fallopian Tube Carcinoma / Fallopian Tube Clear Cell Adenocarcinoma / Fallopian Tube Endometrioid Adenocarcinoma / Fallopian Tube Mucinous Adenocarcinoma / Fallopian Tube Serous Adenocarcinoma / Fallopian Tube Transitional Cell Carcinoma / Fallopian Tube Undifferentiated Carcinoma / FIGO Stage III Ovarian Cancer / FIGO Stage IIIA Ovarian Cancer / FIGO Stage IIIA1 Ovarian Cancer / FIGO Stage IIIA1(i) Ovarian Cancer / FIGO Stage IIIA1(ii) Ovarian Cancer / FIGO Stage IIIA2 Ovarian Cancer / FIGO Stage IIIB Ovarian Cancer / FIGO Stage IIIC Ovarian Cancer / FIGO Stage IVA Ovarian Cancer / FIGO Stage IVB Ovarian Cancer / Malignant Ovarian Brenner Tumor / Ovarian Clear Cell Adenocarcinoma / Ovarian Endometrioid Adenocarcinoma / Ovarian Epithelial Cancer / Ovarian Mucinous Adenocarcinoma / Ovarian Seromucinous Carcinoma / Ovarian Serous Adenocarcinoma / Ovarian Transitional Cell Carcinoma / Ovarian Undifferentiated Carcinoma / Primary Peritoneal Carcinoma / Primary Peritoneal Serous Adenocarcinoma1
2Active Not RecruitingTreatmentGastrin-Producing Neuroendocrine Tumor / Malignant Pancreatic Gastrinoma / Malignant Pancreatic Glucagonoma / Malignant Pancreatic Insulinoma / Malignant Pancreatic Somatostatinoma / Pancreatic Alpha Cell Adenoma / Pancreatic Beta Cell Adenoma / Pancreatic Delta Cell Adenoma / Pancreatic G-Cell Adenoma / Pancreatic Gastrinoma / Pancreatic Glucagonoma / Pancreatic Insulinoma / Pancreatic Neuroendocrine Tumor G1 / Pancreatic Neuroendocrine Tumor G2 / Pancreatic Polypeptide Tumor / Pancreatic Vipoma / Recurrent Pancreatic Carcinoma / Recurrent Pancreatic Neuroendocrine Carcinoma / Somatostatin-Producing Neuroendocrine Tumor / Stage III Pancreatic Cancer / Stage IV Pancreatic Cancer1
2Active Not RecruitingTreatmentGastrinoma / Glucagonoma / Insulinoma / Pancreatic Polypeptide Tumor / Recurrent Islet Cell Carcinoma / Recurrent Pancreatic Cancer / Somatostatinoma / Stage III Pancreatic Cancer / Stage IV Pancreatic Cancer1
2Active Not RecruitingTreatmentGiant Cell Glioblastoma / Glioblastomas / Gliosarcoma1
2Active Not RecruitingTreatmentGlioblastoma - Category / Glioblastoma Multiforme (GBM)1
2Active Not RecruitingTreatmentGlioblastoma Multiforme (GBM)2
2Active Not RecruitingTreatmentGlioblastoma Multiforme (GBM) / Glioblastomas / Gliosarcoma / Malignant Gliomas1
2Active Not RecruitingTreatmentGlioblastoma Multiforme (GBM) / Gliosarcoma1
2Active Not RecruitingTreatmentGlioblastomas3
2Active Not RecruitingTreatmentGlioblastomas / Gliomas1
2Active Not RecruitingTreatmentGlioblastomas / Gliosarcoma / Grade 4 Malignant Glioma / Malignant Gliomas1
2Active Not RecruitingTreatmentGliomas / High Grade Glioma (HGG)1
2Active Not RecruitingTreatmentGliosarcoma / Recurrent Adult Brain Tumor / Recurrent Glioblastoma1
2Active Not RecruitingTreatmentHER2-Negative Breast Cancer / Stage II Breast Cancer / Stage IIIA Breast Cancer / Stage IIIB Breast Cancer / Stage IIIC Breast Cancer1
2Active Not RecruitingTreatmentHemangiosarcoma / Paclitaxel1
2Active Not RecruitingTreatmentLeukemias / Malignant Lymphomas1
2Active Not RecruitingTreatmentLiver Cancer3
2Active Not RecruitingTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)2
2Active Not RecruitingTreatmentLung Cancers4
2Active Not RecruitingTreatmentLung Cancers / Neoplasms Metastasis1
2Active Not RecruitingTreatmentMalignant Peripheral Nerve Sheath Tumour (MPNST) / MPNST / Sarcomas1
2Active Not RecruitingTreatmentMalignant Fibrous Histiocytoma (MFH) of Bone / Sarcoma, Osteogenic1
2Active Not RecruitingTreatmentMalignant Neoplasm of Pancreas2
2Active Not RecruitingTreatmentMalignant Neoplasm of Stomach / Unresectable1
2Active Not RecruitingTreatmentMalignant Neoplasms of Female Genital Organs1
2Active Not RecruitingTreatmentMelanoma (Skin)1
2Active Not RecruitingTreatmentMetastatic Breast Cancer (MBC)2
2Active Not RecruitingTreatmentMetastatic Cancers / Unspecified Adult Solid Tumor, Protocol Specific1
2Active Not RecruitingTreatmentMetastatic Colon Cancer / Recurrent Colon Cancer / Recurrent Rectal Cancer / Stage IV Rectal Cancer1
2Active Not RecruitingTreatmentMetastatic Colorectal Cancers6
2Active Not RecruitingTreatmentMetastatic Melanoma / Mucosal Melanoma / Recurrent Melanoma / Stage IV Cutaneous Melanoma AJCC v6 and v7 / Stage IV Skin Melanoma / Stage IV Uveal Melanoma1
2Active Not RecruitingTreatmentMucinous Adenocarcinoma of the Rectum / Signet Ring Adenocarcinoma of the Rectum / Stage IIA Rectal Cancer / Stage IIB Rectal Cancer / Stage IIC Rectal Cancer / Stage IIIA Rectal Cancer / Stage IIIB Rectal Cancer / Stage IIIC Rectal Cancer1
2Active Not RecruitingTreatmentNeoplasms, Breast1
2Active Not RecruitingTreatmentNeuroblastomas1
2Active Not RecruitingTreatmentNeuroblastomas / Sarcomas1
2Active Not RecruitingTreatmentNeurofibromatosis Type 2 / Progressive Vestibular Schwannomas1
2Active Not RecruitingTreatmentOvarian Sex-cord Stromal Tumor1
2Active Not RecruitingTreatmentRadiation Necrosis1
2Active Not RecruitingTreatmentRectal Adenocarcinoma / Stage II Rectal Cancer / Stage II Rectal Cancer AJCC v7 / Stage III Rectal Cancer / Stage III Rectal Cancer AJCC v71
2Active Not RecruitingTreatmentRectal Carcinoma2
2Active Not RecruitingTreatmentRecurrent Childhood Medulloblastoma / Recurrent Childhood Pineoblastoma / Recurrent Childhood Supratentorial Embryonal Tumor, Not Otherwise Specified / Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor1
2Active Not RecruitingTreatmentRecurrent Colorectal Carcinoma / Refractory Colorectal Carcinoma / Stage IV Colorectal Cancer / Stage IV Colorectal Cancer AJCC v7 / Stage IVA Colorectal Cancer / Stage IVA Colorectal Cancer AJCC v7 / Stage IVB Colorectal Cancer / Stage IVB Colorectal Cancer AJCC v71
2Active Not RecruitingTreatmentRecurrent Melanoma / Stage IIIC Cutaneous Melanoma AJCC v7 / Stage IIIC Skin Melanoma / Stage IV Cutaneous Melanoma AJCC v6 and v7 / Stage IV Skin Melanoma1
2Active Not RecruitingTreatmentRenal Cancers1
2Active Not RecruitingTreatmentRenal Cell Adenocarcinoma2
2Active Not RecruitingTreatmentRenal Cell Carcinoma Recurrent / Stage III Renal Cell Cancer / Stage III Renal Cell Cancer AJCC v7 / Stage IV Renal Cell Cancer / Stage IV Renal Cell Cancer AJCC V71
2Active Not RecruitingTreatmentRetinopathy of Prematurity1
2Active Not RecruitingTreatmentSarcomas1
2Active Not RecruitingTreatmentTransitional Cell Carcinoma1
2Active Not RecruitingTreatmentTumors, Central Nervous System1
2Active Not RecruitingTreatmentMCRC1
2CompletedNot AvailableMacular Degeneration / Macular Edema (ME) / Retinopathy, Diabetic1
2CompletedNot AvailableMalignant Gliomas1
2CompletedDiagnosticCancers1
2CompletedDiagnosticColorectal Cancers / Neoplasms Metastasis1
2CompletedPreventionPancreatic Cancer Metastatic1
2CompletedSupportive CareAdult Anaplastic Astrocytoma / Adult Anaplastic Ependymoma / Adult Anaplastic Meningioma / Adult Anaplastic Oligodendroglioma / Adult Brain Stem Glioma / Adult Central Nervous System Germ Cell Tumor / Adult Choroid Plexus Tumor / Adult Diffuse Astrocytoma / Adult Ependymoma / Adult Grade II Meningioma / Adult Grade III Meningioma / Adult Malignant Hemangiopericytoma / Adult Mixed Glioma / Adult Oligodendroglioma / Adult Papillary Meningioma / Adult Pineocytoma / Meningeal Melanocytoma / Neoplasms, Malignant / Radiation Toxicity / Recurrent Adenoid Cystic Carcinoma of the Oral Cavity / Recurrent Adult Brain Tumor / Recurrent Basal Cell Carcinoma of the Lip / Recurrent Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity / Recurrent Inverted Papilloma of the Paranasal Sinus and Nasal Cavity / Recurrent Lymphoepithelioma of the Nasopharynx / Recurrent Lymphoepithelioma of the Oropharynx / Recurrent Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity / Recurrent Mucoepidermoid Carcinoma of the Oral Cavity / Recurrent Salivary Gland Cancer / Recurrent Squamous Cell Carcinoma of the Hypopharynx / Recurrent Squamous Cell Carcinoma of the Larynx / Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity / Recurrent Squamous Cell Carcinoma of the Nasopharynx / Recurrent Squamous Cell Carcinoma of the Oropharynx / Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity / Recurrent Verrucous Carcinoma of the Larynx / Recurrent Verrucous Carcinoma of the Oral Cavity / Stage I Adenoid Cystic Carcinoma of the Oral Cavity / Stage I Basal Cell Carcinoma of the Lip / Stage I Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity / Stage I Inverted Papilloma of the Paranasal Sinus and Nasal Cavity / Stage I Lymphoepithelioma of the Nasopharynx / Stage I Lymphoepithelioma of the Oropharynx / Stage I Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity / Stage I Mucoepidermoid Carcinoma of the Oral Cavity / Stage I Salivary Gland Cancer / Stage I Squamous Cell Carcinoma of the Hypopharynx / Stage I Squamous Cell Carcinoma of the Larynx / Stage I Squamous Cell Carcinoma of the Lip and Oral Cavity / Stage I Squamous Cell Carcinoma of the Nasopharynx / Stage I Squamous Cell Carcinoma of the Oropharynx / Stage I Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity / Stage I Verrucous Carcinoma of the Larynx / Stage I Verrucous Carcinoma of the Oral Cavity / Stage III Adenoid Cystic Carcinoma of the Oral Cavity / Stage III Basal Cell Carcinoma of the Lip / Stage III Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity / Stage III Inverted Papilloma of the Paranasal Sinus and Nasal Cavity / Stage III Lymphoepithelioma of the Nasopharynx / Stage III Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity / Stage III Mucoepidermoid Carcinoma of the Oral Cavity / Stage III Salivary Gland Cancer / Stage III Squamous Cell Carcinoma of the Hypopharynx / Stage III Squamous Cell Carcinoma of the Larynx / Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity / Stage III Squamous Cell Carcinoma of the Nasopharynx / Stage III Squamous Cell Carcinoma of the Oropharynx / Stage III Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity / Stage III Verrucous Carcinoma of the Larynx / Stage III Verrucous Carcinoma of the Oral Cavity / Stage IV Adenoid Cystic Carcinoma of the Oral Cavity / Stage IV Basal Cell Carcinoma of the Lip / Stage IV Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity / Stage IV Inverted Papilloma of the Paranasal Sinus and Nasal Cavity / Stage IV Lymphoepithelioma of the Nasopharynx / Stage IV Lymphoepithelioma of the Oropharynx / Stage IV Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity / Stage IV Mucoepidermoid Carcinoma of the Oral Cavity / Stage IV Salivary Gland Cancer / Stage IV Squamous Cell Carcinoma of the Hypopharynx / Stage IV Squamous Cell Carcinoma of the Larynx / Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity / Stage IV Squamous Cell Carcinoma of the Nasopharynx / Stage IV Squamous Cell Carcinoma of the Oropharynx / Stage IV Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity / Stage IV Verrucous Carcinoma of the Larynx / Stage IV Verrucous Carcinoma of the Oral Cavity1
2CompletedSupportive CareColorectal Cancers1
2CompletedTreatmentAcoustic Schwannoma / Neurofibromatosis Type 2 / Vestibular Schwannomas1
2CompletedTreatmentAdenocarcinoma of the Cervix / Adenosquamous carcinoma of the cervix / Cervical Adenosquamous Cell Carcinoma / Cervical Squamous Cell Carcinoma / Cervical Squamous Cell Carcinoma, Not Otherwise Specified / Stage IB Cervical Cancer / Stage IB Cervical Cancer AJCC v6 and v7 / Stage IIA Cervical Cancer / Stage IIA Cervical Cancer AJCC v7 / Stage IIB Cervical Cancer / Stage IIB Cervical Cancer AJCC v6 and v7 / Stage III Cervical Cancer / Stage III Cervical Cancer AJCC v6 and v71
2CompletedTreatmentAdenocarcinoma of the Colon / Adenocarcinoma of the Rectum / Advanced Colorectal Cancer1
2CompletedTreatmentAdenocarcinoma of the Esophagus / Adenocarcinomas of the Gastroesophageal Junction / Diffuse Adenocarcinoma of the Stomach / Intestinal Adenocarcinoma of the Stomach / Mixed Adenocarcinoma of the Stomach / Squamous Cell Carcinoma of the Esophagus / Stage IA Esophageal Cancer / Stage IA Gastric Cancer / Stage IB Esophageal Cancer / Stage IB Gastric Cancer / Stage IIA Esophageal Cancer / Stage IIA Gastric Cancer / Stage IIB Esophageal Cancer / Stage IIB Gastric Cancer / Stage IIIA Esophageal Cancer / Stage IIIA Gastric Cancer / Stage IIIB Esophageal Cancer / Stage IIIB Gastric Cancer / Stage IIIC Esophageal Cancer / Stage IIIC Gastric Cancer1
2CompletedTreatmentAdenocarcinoma of the Lung / Adenosquamous Cell Lung Cancer / Bronchoalveolar Cell Lung Cancer / Large Cell Lung Cancer / Non-Small Cell Lung Cancer Recurrent / Squamous Cell Carcinoma of Lung / Stage IIIb Non-small Cell Lung Cancer / Stage IV Non-Small Cell Lung Cancer1
2CompletedTreatmentAdenocarcinoma of the Pancreas / Malignant Neoplasm of Pancreas1
2CompletedTreatmentAdenocarcinoma of the Pancreas / Recurrent Pancreatic Cancer / Stage II Pancreatic Cancer / Stage III Pancreatic Cancer / Stage IV Pancreatic Cancer1
2CompletedTreatmentAdenocarcinoma of the Pancreas / Recurrent Pancreatic Cancer / Stage III Pancreatic Cancer / Stage IV Pancreatic Cancer1
2CompletedTreatmentAdenocarcinoma of the Pancreas / Stage II Pancreatic Cancer / Stage III Pancreatic Cancer1
2CompletedTreatmentAdenocarcinoma of the Prostate / Hormone-Resistant Prostate Cancer / Recurrent Prostate Cancer / Stage IV Prostate Cancer1
2CompletedTreatmentAdenocarcinoma of the Prostate / Prostate Cancer1
2CompletedTreatmentAdenocarcinoma of the Prostate / Recurrent Prostate Cancer / Stage I Prostate Cancer / Stage IIA Prostate Cancer / Stage IIB Prostate Cancer / Stage III Prostate Cancer1
2CompletedTreatmentAdenocarcinoma of the Rectum / Metastatic Colon Cancer / Mucinous Adenocarcinoma of the Colon / Recurrent Colon Cancer / Recurrent Rectal Cancer / Signet Ring Adenocarcinoma of the Colon / Stage IV Rectal Cancer1
2CompletedTreatmentAdenocarcinomas of the Gastroesophageal Junction / Advanced Gastric Cancer / Diffuse Adenocarcinoma of the Stomach / Intestinal Adenocarcinoma of the Stomach / Mixed Adenocarcinoma of the Stomach / Recurrent Gastric Cancer / Stage IIIA Gastric Cancer / Stage IIIB Gastric Cancer / Stage IIIC Gastric Cancer1
2CompletedTreatmentAdenocarcinomas / Carcinoma NOS / Hypernephroid / Nephroid Carcinoma / Renal Cell / Renal Cell Adenocarcinoma1
2CompletedTreatmentAdenocarcinomas / Lung Cancer Non-Small Cell Cancer (NSCLC)1
2CompletedTreatmentAdenosquamous Cell Lung Cancer / Drug/Agent Toxicity by Tissue/Organ / Hemoptysis / Squamous Cell Carcinoma of Lung / Stage IIIb Non-small Cell Lung Cancer / Stage IV Non-Small Cell Lung Cancer1
2CompletedTreatmentAdult Brain Tumors / Malignant Gliomas / Recurrent Glioblastoma Multiforme1
2CompletedTreatmentAdult Glioblastoma / Adult Gliosarcoma / Recurrent Adult Brain Neoplasm / Recurrent Adult Brain Tumor1
2CompletedTreatmentAdult Hepatocellular Carcinoma / Advanced Adult Hepatocellular Carcinoma / Endometrial Serous Adenocarcinoma / Localized Non-Resectable Adult Liver Carcinoma / Lung Carcinoid Tumor / Malignant Ovarian Mixed Epithelial Tumor / Malignant Pancreatic Gastrinoma / Malignant Pancreatic Glucagonoma / Malignant Pancreatic Insulinoma / Malignant Pancreatic Somatostatinoma / Metastatic Digestive System Neuroendocrine Tumor G1 / Ovarian Carcinosarcoma / Ovarian Endometrioid Adenocarcinoma / Ovarian Seromucinous Carcinoma / Ovarian Serous Surface Papillary Adenocarcinoma / Pancreatic Alpha Cell Adenoma / Pancreatic Beta Cell Adenoma / Pancreatic Delta Cell Adenoma / Pancreatic G-Cell Adenoma / Pancreatic Polypeptide Tumor / Recurrent Adult Liver Carcinoma / Recurrent Digestive System Neuroendocrine Tumor G1 / Recurrent Fallopian Tube Carcinoma / Recurrent Ovarian Carcinoma / Recurrent Pancreatic Neuroendocrine Carcinoma / Recurrent Primary Peritoneal Carcinoma / Recurrent Uterine Corpus Carcinoma / Regional Digestive System Neuroendocrine Tumor G1 / Stage IIIA Fallopian Tube Cancer / Stage IIIA Ovarian Cancer / Stage IIIA Primary Peritoneal Cancer / Stage IIIA Uterine Corpus Cancer / Stage IIIB Fallopian Tube Cancer / Stage IIIB Ovarian Cancer / Stage IIIB Primary Peritoneal Cancer / Stage IIIB Uterine Corpus Cancer / Stage IIIC Fallopian Tube Cancer / Stage IIIC Ovarian Cancer / Stage IIIC Primary Peritoneal Cancer / Stage IIIC Uterine Corpus Cancer / Stage IV Fallopian Tube Cancer / Stage IV Ovarian Cancer / Stage IV Primary Peritoneal Cancer / Stage IVA Uterine Corpus Cancer / Stage IVB Uterine Corpus Cancer / Uterine Carcinosarcoma1
2CompletedTreatmentAdult Primary Hepatocellular Carcinoma / Advanced Adult Primary Liver Cancer / Localized Unresectable Adult Primary Liver Cancer / Recurrent Adult Primary Liver Cancer1
2CompletedTreatmentAdult Primary Hepatocellular Carcinoma / Localized Unresectable Adult Primary Liver Cancer / Recurrent Adult Primary Liver Cancer1
2CompletedTreatmentAdult Rhabdomyosarcoma / Childhood Alveolar Rhabdomyosarcoma / Childhood Pleomorphic Rhabdomyosarcoma / Childhood Rhabdomyosarcoma With Mixed Embryonal and Alveolar Features / Previously Treated Childhood Rhabdomyosarcoma / Recurrent Adult Soft Tissue Sarcoma / Recurrent Childhood Rhabdomyosarcoma1
2CompletedTreatmentAdvanced Malignant Mesothelioma / Epithelial Mesothelioma / Localized Malignant Mesothelioma / Recurrent Malignant Mesothelioma / Sarcomatous Mesothelioma1
2CompletedTreatmentAdvanced Non-Small Cell Lung Cancer / Lung Cancer Non-Small Cell Cancer (NSCLC) / Non-Small Cell Lung Cancer Recurrent1
2CompletedTreatmentAdverse Effect of Radiation Therapy / Brain Necrosis / Nasopharyngeal Carcinoma1
2CompletedTreatmentAge Related Macular Degeneration (ARMD)1
2CompletedTreatmentAge Related Macular Degeneration (ARMD) / Macular Edema (ME) / Subfoveal Choroidal Neovascularization1
2CompletedTreatmentAge Related Macular Degeneration (ARMD) / Proliferative Diabetic Retinopathy (PDR)1
2CompletedTreatmentAmpulla of Vater Adenocarcinoma / Gastrointestinal Cancers / Small Intestinal Adenocarcinoma / Stage III Ampulla of Vater Cancer AJCC v8 / Stage III Small Intestinal Adenocarcinoma AJCC v8 / Stage IIIA Ampulla of Vater Cancer AJCC v8 / Stage IIIA Small Intestinal Adenocarcinoma AJCC v8 / Stage IIIB Ampulla of Vater Cancer AJCC v8 / Stage IIIB Small Intestinal Adenocarcinoma AJCC v8 / Stage IV Ampulla of Vater Cancer AJCC v8 / Stage IV Small Intestinal Adenocarcinoma AJCC v81
2CompletedTreatmentAnaplastic Astrocytoma (AA) / Anaplastic Mixed Oligoastrocytoma / Anaplastic Oligodendroglioma (AO) / Glioblastomas / Gliosarcoma1
2CompletedTreatmentAnaplastic Large Cell Lymphoma / Recurrent Adult Burkitt Lymphoma / Recurrent Adult Diffuse Large Cell Lymphoma / Recurrent Mantle Cell Lymphoma1
2CompletedTreatmentAstrocytomas / Glioblastomas1
2CompletedTreatmentB-Cell Chronic Lymphocytic Leukemia / Chronic Lymphocytic Leukemia (CLL) - Refractory1
2CompletedTreatmentBasal Cell Carcinoma (BCC) / Cancer of the Ovary / Metastatic Colorectal Cancers1
2CompletedTreatmentBiliary Tract Cancer / Gallbladder Adenocarcinoma2
2CompletedTreatmentBladder Cancers3
2CompletedTreatmentBrain Cancer / Glioblastomas1
2CompletedTreatmentBrain Cancer / Pediatric Cancers1
2CompletedTreatmentBrain and Central Nervous System Tumors3
2CompletedTreatmentBreast Cancer Invasive Nos1
2CompletedTreatmentCancer of the Ovary7
2CompletedTreatmentCancer of the Ovary / Carcinoma of the Vulva / Cervical Cancers / Endometrial Cancers / Vaginal Cancers1
2CompletedTreatmentCancer of the Ovary / Clear Cell Mullerian Tumor / Fallopian Tube Cancer / Papillary Serous Mullerian Tumor / Primary Peritoneal Cancer1
2CompletedTreatmentCancer of the Ovary / Fallopian Tube Cancer / Malignant Peritoneal Neoplasm3
2CompletedTreatmentCancer of the Ovary / Fallopian Tube Cancer / Malignant Tumor of Peritoneum1
2CompletedTreatmentCancer of the Ovary / Fallopian Tube Cancer / Primary Peritoneal Carcinoma2
2CompletedTreatmentCancer of the Rectum / Colorectal Cancers / Rectal Carcinoma1
2CompletedTreatmentCancer, Breast39
2CompletedTreatmentCancer, Breast / Metastatic Breast Cancer (MBC)1
2CompletedTreatmentCancer, Breast / Metastatic Breast Cancer (MBC) / Progressive Breast Cancer1
2CompletedTreatmentCancer, Breast / Neoplasms, Breast1
2CompletedTreatmentCancers4
2CompletedTreatmentCancers / Colorectal Cancers / Malignant Neoplasm of Colon / Metastatic Cancers / Metastatic Colorectal Cancers / Rectal Carcinoma1
2CompletedTreatmentCancers / Myeloproliferative Disorders / Transitional Cell Carcinoma1
2CompletedTreatmentCarcinoma NOS1
2CompletedTreatmentCervical Cancers1
2CompletedTreatmentCervical Squamous Cell Carcinoma / Recurrent Cervical Cancer1
2CompletedTreatmentChildhood Cerebral Anaplastic Astrocytoma / Childhood Oligodendroglioma / Childhood Spinal Cord Neoplasm / Recurrent Childhood Brain Stem Glioma / Recurrent Childhood Ependymoma / Recurrent Childhood Medulloblastoma1
2CompletedTreatmentCholangiocarcinoma of the Extrahepatic Bile Duct / Cholangiocarcinoma of the Gallbladder / Gastrointestinal Cancers / Recurrent Extrahepatic Bile Duct Cancer / Recurrent Gallbladder Cancer / Unresectable Extrahepatic Bile Duct Cancer / Unresectable Gallbladder Cancer1
2CompletedTreatmentCholangiocarcinomas2
2CompletedTreatmentCholangiocarcinomas / Gallbladder Cancer1
2CompletedTreatmentChoriocarcinoma1
2CompletedTreatmentChronic Lymphocytic Leukaemia (CLL)2
2CompletedTreatmentClear Cell Renal Cell Carcinoma / Renal Cell Carcinoma Recurrent / Stage IV Renal Cell Cancer / Type 1 Papillary Renal Cell Carcinoma / Type 2 Papillary Renal Cell Carcinoma1
2CompletedTreatmentColorectal Adenocarcinoma1
2CompletedTreatmentColorectal Cancer (CRC)1
2CompletedTreatmentColorectal Cancer Stage II1
2CompletedTreatmentColorectal Cancers37
2CompletedTreatmentColorectal Cancers / Liver Metastasis1
2CompletedTreatmentColorectal Cancers / Malignant Neoplasm of Colon / Metastatic Colorectal Cancers / Rectal Carcinoma1
2CompletedTreatmentColorectal Cancers / Neoplasms Metastasis1
2CompletedTreatmentColorectal Cancers / Neoplasms, Colorectal1
2CompletedTreatmentColorectal Cancers / Rectal Carcinoma1
2CompletedTreatmentColorectal, Cancer1
2CompletedTreatmentContiguous Stage II Adult Diffuse Large Cell Lymphoma / Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma / Stage III Adult Diffuse Large Cell Lymphoma / Stage IV Adult Diffuse Large Cell Lymphoma1
2CompletedTreatmentDiabetes Mellitus (DM) / Diabetic Macular Edema (DME) / Retinopathy, Diabetic1
2CompletedTreatmentDiabetic Macular Edema (DME)3
2CompletedTreatmentDiffuse Intrinsic Pontine Glioma (DIPG)1
2CompletedTreatmentEndometrial Adenocarcinomas / Endometrial Adenosquamous Carcinoma / Endometrial Adenosquamous Cell Carcinoma / Endometrial Clear Cell Adenocarcinoma / Endometrial Clear Cell Carcinoma / Endometrial Papillary Serous Carcinoma / Endometrial Serous Adenocarcinoma / Stage I Endometrial Carcinoma / Stage IA Uterine Corpus Cancer AJCC v7 / Stage IB Uterine Corpus Cancer AJCC v7 / Stage II Endometrial Carcinoma / Stage II Uterine Corpus Cancer AJCC v7 / Stage III Endometrial Carcinoma / Stage IIIA Uterine Corpus Cancer AJCC v7 / Stage IIIB Uterine Corpus Cancer AJCC v7 / Stage IIIC Uterine Corpus Cancer AJCC v7 / Stage IV Endometrial Carcinoma / Stage IVA Uterine Corpus Cancer AJCC v7 / Stage IVB Uterine Corpus Cancer AJCC v71
2CompletedTreatmentEndometrial Cancers1
2CompletedTreatmentEndometrial Carcinoma1
2CompletedTreatmentEsophageal Cancers2
2CompletedTreatmentEsophageal Cancers / Malignant Neoplasm of Stomach3
2CompletedTreatmentEwing Sarcoma of Bone / Extraosseous Ewing Sarcoma / Peripheral Primitive Neuroectodermal Tumor / Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor1
2CompletedTreatmentExtensive Stage Small Cell Lung Cancer2
2CompletedTreatmentFallopian Tube Cancer / Neoplasms, Ovarian / Primary Peritoneal Cancer1
2CompletedTreatmentFallopian Tube Cancer / Primary Peritoneal Cavity Cancer / Recurrent Ovarian Epithelial Cancer / Stage IV Ovarian Epithelial Cancer1
2CompletedTreatmentFollicular Lymphoma (FL)1
2CompletedTreatmentGastrointestinal Cancers / Malignant Ascites1
2CompletedTreatmentGastrooesophageal Cancer / Malignant Neoplasm of Stomach1
2CompletedTreatmentGiant Cell Glioblastoma / Glioblastoma With Oligodendroglial Component / Glioblastomas / Gliosarcoma / Recurrent Glioblastoma / Relapsed Glioblastoma / Small Cell Glioblastoma1
2CompletedTreatmentGlioblastoma Multiforme (GBM)8
2CompletedTreatmentGlioblastoma Multiforme (GBM) / Glioblastomas1
2CompletedTreatmentGlioblastoma Multiforme (GBM) / Gliosarcoma2
2CompletedTreatmentGlioblastoma Multiforme (GBM) / Primary Brain Tumors1
2CompletedTreatmentGlioblastomas7
2CompletedTreatmentGlioblastomas / Gliomas / Recurrent Brain Tumors1
2CompletedTreatmentGlioblastomas / Gliosarcoma6
2CompletedTreatmentGlioblastomas / Gliosarcoma / Neoplasms, Brain1
2CompletedTreatmentGliomas2
2CompletedTreatmentGliomas / Neoplasms, Brain1
2CompletedTreatmentHIV Seronegativity / Human Immunodeficiency Virus (HIV) Infections / Kaposi s Sarcoma (KS)1
2CompletedTreatmentHead and Neck Carcinoma3
2CompletedTreatmentHead and Neck Carcinoma / Squamous Cell Carcinoma (SCC)1
2CompletedTreatmentHemangiosarcoma / Histiocytoma / Leiomyosarcomas / Malignant Fibrous / Sarcomas1
2CompletedTreatmentHemorrhagic Hereditary Telangiectasia (HHT)1
2CompletedTreatmentHepatocellular,Carcinoma3
2CompletedTreatmentHepatocellular,Carcinoma / Liver Cancer1
2CompletedTreatmentHereditary Haemorrhagic Telangiectasia (HHT) / Morbus Osler / Nasal Bleeding1
2CompletedTreatmentHereditary Haemorrhagic Telangiectasia (HHT) / Nasal Bleeding1
2CompletedTreatmentIdiopathic Polypoidal Choroidal Vasculopathy1
2CompletedTreatmentKaposi s Sarcoma (KS)2
2CompletedTreatmentLeptomeningeal Metastasis / Metastatic Brain Tumors / Neoplasms, Breast1
2CompletedTreatmentLeukemias / Myelodysplastic Syndromes1
2CompletedTreatmentLiver Cancer5
2CompletedTreatmentLiver Only Metastasis From KRAS Exon 2 Wild Type (Under Protocol 1.0-1.2 Edition) and RAS Wild Type (Under Protocol 2.0 Edition) Colorectal Cancer1
2CompletedTreatmentLocally Advanced Breast Cancer (LABC) / Metastatic Breast Cancer (MBC)1
2CompletedTreatmentLocally Advanced Non-Small Cell Lung Cancer / Lung Cancer Non-Small Cell Cancer (NSCLC)1
2CompletedTreatmentLocally Recurrent and Metastatic Breast Cancer1
2CompletedTreatmentLocally Recurrent or Metastatic Breast Cancer1
2CompletedTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)32
2CompletedTreatmentLung Cancer Non-Small Cell Cancer (NSCLC) / Lung Cancers1
2CompletedTreatmentLung Cancer Non-Small Cell Cancer (NSCLC) / Neoplasm Recurrence, Local1
2CompletedTreatmentLung Cancer Non-Small Cell Cancer (NSCLC) / Neoplasms, Brain1
2CompletedTreatmentLung Cancer Small Cell Lung Cancer (SCLC)2
2CompletedTreatmentLung Cancers18
2CompletedTreatmentLung Cancers / Small Cell Lung Carcinoma1
2CompletedTreatmentMacular Degeneration2
2CompletedTreatmentMacular Degeneration / Subfoveal Choroidal Neovascularization1
2CompletedTreatmentMacular Edema (ME) / Retinopathy, Diabetic1
2CompletedTreatmentMale Breast Cancer / Recurrent Breast Cancer / Stage IV Breast Cancer1
2CompletedTreatmentMale Breast Cancer / Stage II Breast Cancer / Stage IIIA Breast Cancer / Stage IIIB Breast Cancer1
2CompletedTreatmentMalignant Gliomas1
2CompletedTreatmentMalignant Gliomas / Recurrent High-Grade Gliomas1
2CompletedTreatmentMalignant Lymphomas3
2CompletedTreatmentMalignant Melanoma2
2CompletedTreatmentMalignant Neoplasm of Colon1
2CompletedTreatmentMalignant Neoplasm of Pancreas7
2CompletedTreatmentMalignant Ovarian Epithelial Tumor / Ovarian Granulosa Cell Tumor / Ovarian Gynandroblastoma / Ovarian Sertoli-Leydig Cell Tumors / Ovarian Sex Cord Tumor With Annular Tubules / Ovarian Sex Cord-Stromal Tumor / Ovarian Sex Cord-Stromal Tumor of Mixed or Unclassified Cell Types / Ovarian Steroid Cell Tumor / Ovarian Stromal Cancer1
2CompletedTreatmentMelanoma3
2CompletedTreatmentMelanoma (Skin)2
2CompletedTreatmentMesothelioma3
2CompletedTreatmentMetastases / Renal Cell Adenocarcinoma1
2CompletedTreatmentMetastatic Breast Cancer (MBC)8
2CompletedTreatmentMetastatic Colorectal Cancers10
2CompletedTreatmentMetastatic Gastrointestinal Carcinoid Tumor / Recurrent Gastrointestinal Carcinoid Tumor / Regional Gastrointestinal Carcinoid Tumor1
2CompletedTreatmentMetastatic Hormone Refractory Prostate Cancer1
2CompletedTreatmentMetastatic Malignant Melanoma1
2CompletedTreatmentMetastatic Melanoma3
2CompletedTreatmentMetastatic Non-Small Cell Lung Cancer / Nonsquamous Nonsmall Cell Neoplasm of Lung1
2CompletedTreatmentMetastatic Renal Cell Carcinoma2
2CompletedTreatmentMultiple Myeloma (MM)2
2CompletedTreatmentMultiple Myeloma and Plasma Cell Neoplasm2
2CompletedTreatmentNaive Unresectable Glioblastoma1
2CompletedTreatmentNeoplasms2
2CompletedTreatmentNeoplasms Metastasis / Neoplasms, Esophageal / Stomach Neoplasms1
2CompletedTreatmentNeoplasms, Breast1
2CompletedTreatmentNeoplasms, Colorectal5
2CompletedTreatmentNeoplasms, Esophageal / Stomach Neoplasms1
2CompletedTreatmentNeoplasms, Germ Cell and Embryonal1
2CompletedTreatmentNeoplasms, Ovarian2
2CompletedTreatmentNeoplasms, Pancreatic1
2CompletedTreatmentNeovascular Age-Related Macular Degeneration1
2CompletedTreatmentNeuroendocrine Carcinomas2
2CompletedTreatmentNeuroendocrine Tumors2
2CompletedTreatmentNon-Squamous Non-Small Cell Lung Cancer4
2CompletedTreatmentOvarian Carcinoma / Primary Peritoneal Carcinoma1
2CompletedTreatmentOvarian Epithelial Cancer / Primary Peritoneal Carcinoma1
2CompletedTreatmentPrimary Peritoneal Carcinoma / Recurrent Ovarian Carcinoma / Stage IV Ovarian Cancer1
2CompletedTreatmentPrimary Peritoneal Cavity Cancer / Recurrent Ovarian Epithelial Cancer / Stage IV Ovarian Epithelial Cancer1
2CompletedTreatmentProstate Cancer5
2CompletedTreatmentProstatic Neoplasms1
2CompletedTreatmentPterygium2
2CompletedTreatmentRectal Adenocarcinoma1
2CompletedTreatmentRectal Carcinoma4
2CompletedTreatmentRectum Cancer1
2CompletedTreatmentRecurrent Breast Cancer / Stage IV Breast Cancer1
2CompletedTreatmentRecurrent Breast Carcinoma / Stage IV Breast Cancer1
2CompletedTreatmentRecurrent Colon Cancer / Recurrent Rectal Cancer / Stage IVA Colon Cancer / Stage IVA Rectal Cancer / Stage IVB Colon Cancer / Stage IVB Rectal Cancer1
2CompletedTreatmentRecurrent Endometrial Carcinoma2
2CompletedTreatmentRecurrent Fallopian Tube Carcinoma / Recurrent Ovarian Carcinoma / Recurrent Primary Peritoneal Carcinoma1
2CompletedTreatmentRecurrent Glioblastoma1
2CompletedTreatmentRecurrent Glioblastoma Multiforme / Recurrent Gliosarcoma1
2CompletedTreatmentRecurrent Melanoma / Stage IIIA Skin Melanoma / Stage IIIB Skin Melanoma / Stage IIIC Skin Melanoma / Stage IV Skin Melanoma1
2CompletedTreatmentRecurrent Melanoma / Stage IV Melanoma1
2CompletedTreatmentRecurrent Melanoma / Stage IV Skin Melanoma1
2CompletedTreatmentRecurrent Melanoma / Stage IV Skin Melanoma / Stages III Skin Melanoma1
2CompletedTreatmentRenal Cancers4
2CompletedTreatmentRenal Cancers / Renal Cell Adenocarcinoma3
2CompletedTreatmentRenal Cell Adenocarcinoma3
2CompletedTreatmentRenal Cell Cancer, Recurrent / Stage IV Renal Cell Cancer1
2CompletedTreatmentRenal Cell Carcinoma Recurrent / Stage IV Renal Cell Cancer1
2CompletedTreatmentRetinal Detachment / Retinopathy, Diabetic1
2CompletedTreatmentRetinal Neovascularization1
2CompletedTreatmentRetinopathy, Diabetic1
2CompletedTreatmentSarcomas2
2CompletedTreatmentSmall Cell Lung Carcinoma1
2CompletedTreatmentSquamous Cell Carcinoma of the Head and Neck (SCCHN)1
2CompletedTreatmentStage IA Pancreatic Cancer / Stage IB Pancreatic Cancer / Stage IIA Pancreatic Cancer / Stage IIB Pancreatic Cancer1
2CompletedTreatmentStage II Nasopharyngeal Keratinizing Squamous Cell Carcinoma AJCC v7 / Stage II Squamous Cell Carcinoma of the Nasopharynx / Stage III Lymphoepithelioma of the Nasopharynx / Stage III Nasopharyngeal Keratinizing Squamous Cell Carcinoma AJCC v7 / Stage III Nasopharyngeal Undifferentiated Carcinoma AJCC v7 / Stage III Squamous Cell Carcinoma of the Nasopharynx / Stage IV Lymphoepithelioma of the Nasopharynx / Stage IV Nasopharyngeal Keratinizing Squamous Cell Carcinoma AJCC v7 / Stage IV Nasopharyngeal Undifferentiated Carcinoma AJCC v7 / Stage IV Squamous Cell Carcinoma of the Nasopharynx1
2CompletedTreatmentStage III Ovarian Cancer / Stage IV Ovarian Cancer1
2CompletedTreatmentAdvanced thymic carcinoma / Thymic Cancer1
2CompletedTreatmentTumors1
2CompletedTreatmentUnknown Primary Neoplasms2
2CompletedTreatmentUntreated Mantle Cell Lymphoma1
2Enrolling by InvitationTreatmentColorectal Cancers1
2Enrolling by InvitationTreatmentLung Cancer Non-Small Cell Cancer (NSCLC) / Malignant Pleural Effusions1
2Not Yet RecruitingTreatmentAdvanced Ovarian Cancer1
2Not Yet RecruitingTreatmentCancer of the Ovary1
2Not Yet RecruitingTreatmentColonic Neoplasms / Neoplasms Metastasis / Neoplasms, Colorectal / Rectal Neoplasms1
2Not Yet RecruitingTreatmentColorectal Adenocarcinoma / Stage IVA Colorectal Cancer / Stage IVB Colorectal Cancer1
2Not Yet RecruitingTreatmentColorectal Cancers1
2Not Yet RecruitingTreatmentColorectal Cancers / Metastatic Cancers1
2Not Yet RecruitingTreatmentColorectal Carcinomatosis1
2Not Yet RecruitingTreatmentEfficacy / Metastatic Triple Negative Breast Cancer / Safety Issues1
2Not Yet RecruitingTreatmentEndometrial Cancers1
2Not Yet RecruitingTreatmentGlioblastomas1
2Not Yet RecruitingTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)2
2Not Yet RecruitingTreatmentMetastatic Colorectal Cancers / MSI1
2Not Yet RecruitingTreatmentMalignant Neoplasm of Pancreas1
2Not Yet RecruitingTreatmentMesothelioma, Malignant1
2Not Yet RecruitingTreatmentMetastatic Colorectal Cancers1
2Not Yet RecruitingTreatmentPancreatic Cancer Metastatic1
2RecruitingOtherCancer, Breast / Estrogen Receptor-Positive Breast Cancer1
2RecruitingSupportive CareMetastatic Brain Tumors / Radionecrosis1
2RecruitingTreatmentAdult Giant Cell Glioblastoma / Adult Glioblastoma / Adult Gliosarcoma / Recurrent Adult Brain Tumor1
2RecruitingTreatmentAdvanced Colorectal Cancer1
2RecruitingTreatmentAdvanced Non-Clear Cell Kidney Cancer1
2RecruitingTreatmentAnaplastic (Malignant) Meningioma / Atypical Meningioma / Grade II Meningioma / Grade III Meningioma / Recurrent Meningiomas / Supratentorial Meningioma1
2RecruitingTreatmentAnaplastic Ependymoma / Ependymomas1
2RecruitingTreatmentAnaplastic Thyroid Carcinoma / Malignant Neoplasms of Thyroid and Other Endocrine Glands / Poorly Differentiated Thyroid Cancer1
2RecruitingTreatmentAstrocytomas1
2RecruitingTreatmentBevacizumab / Metastatic Brain Tumors / Non Squamous Non-small Cell Lung Cancer1
2RecruitingTreatmentCancer - Metastatic Colorectal / Cancers1
2RecruitingTreatmentCancer of Unknown Primary Site1
2RecruitingTreatmentCancer of the Ovary1
2RecruitingTreatmentCancer of the Ovary / Fallopian Tube Cancer / Malignant Neoplasms of Female Genital Organs / Primary Peritoneal Cancer1
2RecruitingTreatmentCancer of the Ovary / Fallopian Tube Cancer / Primary Peritoneal Carcinoma2
2RecruitingTreatmentCancer, Breast1
2RecruitingTreatmentCancer, Breast / Estrogen Receptor Negative / HER2/Neu Negative / Invasive Breast Carcinoma / Progesterone Receptor Negative / Triple-Negative Breast Carcinoma1
2RecruitingTreatmentCancer, Breast / Metastatic Brain Tumors1
2RecruitingTreatmentCarcinoma, Breast1
2RecruitingTreatmentCarcinoma, Colorectal / Colorectal Adenocarcinoma / Colorectal Cancers / Colorectal Tumors / Neoplasms, Colorectal1
2RecruitingTreatmentCervical Cancers1
2RecruitingTreatmentCervical Cancers / Endometrial Cancers1
2RecruitingTreatmentCollecting Duct Carcinoma (Kidney)1
2RecruitingTreatmentColorectal Cancers1
2RecruitingTreatmentCancer treatment / Colorectal Cancers / MSI / Resistance, APC1
2RecruitingTreatmentColorectal Cancers / Neoplasms / Neoplasms, Metastatic1
2RecruitingTreatmentEGFR Activating Mutation / EGFR NP_005219.2:p.T790M / Lung Carcinoma Metastatic in the Brain / Metastatic Malignant Neoplasm in the Brain / Non-Small Cell Lung Carcinoma (NSCLC) / Recurrent Non-Small Cell Lung Carcinoma1
2RecruitingTreatmentEGFR Activating Mutation / NSCLC Stage IIIB / NSCLC Stage IV1
2RecruitingTreatmentEndometrial Cancers1
2RecruitingTreatmentExtranodal NK/T-cell Lymphoma, Nasal Type1
2RecruitingTreatmentFallopian Tube Cancer / Ovarian Epithelial Cancer / Primary Peritoneal Cancer1
2RecruitingTreatmentFallopian Tube Clear Cell Adenocarcinoma / Fallopian Tube Endometrioid Adenocarcinoma / Fallopian Tube Mucinous Adenocarcinoma / Fallopian Tube Serous Adenocarcinoma / Ovarian Clear Cell Adenocarcinoma / Ovarian Endometrioid Adenocarcinoma / Ovarian Mucinous Adenocarcinoma / Ovarian Serous Adenocarcinoma / Primary Peritoneal Serous Adenocarcinoma / Recurrent Fallopian Tube Carcinoma / Recurrent Ovarian Carcinoma / Recurrent Primary Peritoneal Carcinoma / Undifferentiated Fallopian Tube Carcinoma / Undifferentiated Ovarian Carcinoma1
2RecruitingTreatmentFallopian Tube Endometrioid Adenocarcinoma / High Grade Fallopian Tube Serous Adenocarcinoma / High Grade Ovarian Serous Adenocarcinoma / Ovarian Endometrioid Adenocarcinoma / Platinum-Resistant Ovarian Carcinoma / Primary Peritoneal High Grade Serous Adenocarcinoma / Refractory Fallopian Tube Carcinoma / Refractory Ovarian Carcinoma / Refractory Primary Peritoneal Carcinoma1
2RecruitingTreatmentGBM / Glioblastoma Multiforme (GBM) / Glioblastomas / Malignant Gliomas1
2RecruitingTreatmentGlioblastoma Multiforme (GBM) / Glioblastomas1
2RecruitingTreatmentGlioblastomas1
2RecruitingTreatmentGlioblastomas / Gliomas / Gliosarcoma1
2RecruitingTreatmentGlioblastomas / Gliosarcoma1
2RecruitingTreatmentGliomas1
2RecruitingTreatmentHLRCC / Metastatic Papillary RCC1
2RecruitingTreatmentHigh Grade Recurrent Glioma and Newly Diagnosed Glioblastoma1
2RecruitingTreatmentHuman Epidermal Growth Factor 2 Negative Carcinoma of Breast / Metastatic Breast Cancer (MBC)1
2RecruitingTreatmentLow Grade Glioma (LGG)1
2RecruitingTreatmentMalignant Neoplasm of Colon1
2RecruitingTreatmentMalignant Neoplasms of Digestive Organs / Malignant Neoplasms of Lip Oral Cavity and Pharynx / Malignant Neoplasms of Mesothelial and Soft Tissue / Malignant Neoplasms of Respiratory and Intrathoracic Organs1
2RecruitingTreatmentMalignant Pleural Effusions1
2RecruitingTreatmentMedulloblastomas1
2RecruitingTreatmentMelanoma1
2RecruitingTreatmentMelanoma and Other Malignant Neoplasms of Skin1
2RecruitingTreatmentMetastatic Breast Cancer (MBC)1
2RecruitingTreatmentMetastatic Colorectal Cancers5
2RecruitingTreatmentMetastatic Renal Cell Carcinoma1
2RecruitingTreatmentMicrosatellite Stable / Mismatch Repair Protein Proficient / Stage III Colorectal Cancer AJCC v7 / Stage IIIB Colorectal Cancer AJCC v7 / Stage IIIC Colorectal Cancer AJCC v7 / Stage IV Colorectal Cancer AJCC v7 / Stage IVA Colorectal Cancer AJCC v7 / Stage IVB Colorectal Cancer AJCC v71
2RecruitingTreatmentNasopharyngeal Neoplasms1
2RecruitingTreatmentNeoplasms, Colorectal1
2RecruitingTreatmentCancer treatment / Neoplasms, Colorectal1
2RecruitingTreatmentNeoplasms, Ovarian1
2RecruitingTreatmentNeuroblastomas1
2RecruitingTreatmentNon Small Cell Lung Cancer Metastatic1
2RecruitingTreatmentOvarian Epithelial Cancer1
2RecruitingTreatmentPeritoneal Adhesion1
2RecruitingTreatmentPulmonary Fibrosis1
2RecruitingTreatmentRectal Carcinoma1
2RecruitingTreatmentRecurrent Fallopian Tube Carcinoma / Recurrent Ovarian Carcinoma / Recurrent Primary Peritoneal Carcinoma1
2RecruitingTreatmentRecurrent Glioblastoma1
2RecruitingTreatmentRecurrent Ovarian Epithelial Cancer1
2RecruitingTreatmentRecurrent Respiratory Papillomatosis1
2RecruitingTreatmentRhabdomyosarcomas1
2RecruitingTreatmentStage III Esophageal Squamous Cell Carcinoma1
2RecruitingTreatmentStage III-IV or Recurrent Endometrial Cancer1
2RecruitingTreatmentTransitional Cell Carcinoma1
2RecruitingTreatmentWet Age-Related Macular Degeneration / Wet Macular Degeneration1
2RecruitingTreatmentMetastatic Lung Adenocarcinoma1
2SuspendedTreatmentColorectal Cancers1
2SuspendedTreatmentGerm Cell Tumors1
2TerminatedTreatmentAge-Related Macular Degeneration (AMD) / AMD / Eye Diseases / Macular Degeneration / Macular Degeneration, Age-related, 10 / Neovascular Age-Related Macular Degeneration / Retinal Degenerations / Retinal Diseases1
2TerminatedTreatmentAdenocarcinoma of the Lung / Bronchioloalveolar Carcinoma / Bronchioloalveolar Lung Carcinoma / Large Cell Lung Carcinoma / Recurrent Non-Small Cell Lung Carcinoma / Stage IV Non-Small Cell Lung Cancer1
2TerminatedTreatmentAdenocarcinomas / Malignant Neoplasm of Colon1
2TerminatedTreatmentAcute, secondary Myeloid Leukemia / Adult Acute Basophilic Leukemia / Adult Acute Eosinophilic Leukemia / Adult Acute Megakaryoblastic Leukemia (M7) / Adult Acute Minimally Differentiated Myeloid Leukemia (M0) / Adult Acute Monoblastic Leukemia (M5a) / Adult Acute Monocytic Leukemia (M5b) / Adult Acute Myeloblastic Leukemia With Maturation (M2) / Adult Acute Myeloblastic Leukemia Without Maturation (M1) / Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities / Adult Acute Myelomonocytic Leukemia (M4) / Adult Erythroleukemia (M6a) / Adult Pure Erythroid Leukemia (M6b) / Childhood Acute Basophilic Leukemia / Childhood Acute Eosinophilic Leukemia / Childhood Acute Erythroleukemia (M6) / Childhood Acute Megakaryocytic Leukemia (M7) / Childhood Acute Monoblastic Leukemia (M5a) / Childhood Acute Monocytic Leukemia (M5b) / Childhood Acute Myeloblastic Leukemia With Maturation (M2) / Childhood Acute Myeloblastic Leukemia Without Maturation (M1) / Childhood Acute Myelomonocytic Leukemia (M4) / Untreated Adult Acute Myeloid Leukemia / Untreated Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies1
2TerminatedTreatmentAdvanced Non-Small Cell Lung Cancer / Non-Small Cell Lung Cancer Stage IIIB / Stage IIIB or IV Non-Small Cell Lung Cancer1
2TerminatedTreatmentAdvanced Non-squamous NSCLC1
2TerminatedTreatmentAge-Related Macular Degeneration (ARMD)2
2TerminatedTreatmentAgnogenic Myeloid Metaplasia1
2TerminatedTreatmentBiliary Tract Cancer1
2TerminatedTreatmentBlastic Phase Chronic Myelogenous Leukemia / Chronic Myelogenous Leukemia, BCR-ABL1 Positive1
2TerminatedTreatmentBrain Cancer1
2TerminatedTreatmentCancer of the Ovary1
2TerminatedTreatmentCancer of the Ovary / Cancer, Breast1
2TerminatedTreatmentCancer of the Ovary / Fallopian Tube Cancer / Malignant Peritoneal Neoplasm / Stage 3 Cancer / Stage 4 Cancer1
2TerminatedTreatmentCancer of the Ovary / Fallopian Tube Cancer / Primary Peritoneal Cancer1
2TerminatedTreatmentCancer of the Ovary / Fallopian Tube Cancer / Primary Peritoneal Serous Cancer1
2TerminatedTreatmentCancer of the Ovary / Malignant Peritoneal Neoplasm1
2TerminatedTreatmentCancer, Breast7
2TerminatedTreatmentCancer, Breast / Locally Recurrent and Metastatic Breast Cancer / Neoplasms, Breast / Tumors, Breast1
2TerminatedTreatmentCarcinoma NOS / Metastatic Cancers / Neoplasms, Thyroid / Thyroid Cancers1
2TerminatedTreatmentCarcinoma, Colorectal1
2TerminatedTreatmentCervical Cancers / Uterine Cancers1
2TerminatedTreatmentColorectal Cancers7
2TerminatedTreatmentColorectal Cancers / Metastases2
2TerminatedTreatmentColorectal Cancers / Metastatic Cancers1
2TerminatedTreatmentColorectal Cancers / Neoplasms Metastasis1
2TerminatedTreatmentColorectal Liver Metastases1
2TerminatedTreatmentCystoid Macular Edema / Macular Edema (ME) / Radiation Maculopathy / Radiation Retinopathy / Uveal Melanoma1
2TerminatedTreatmentEsophageal Diseases / Neoplasms, Esophageal1
2TerminatedTreatmentFallopian Tube Cancer / Ovarian Epithelial Cancer / Primary Peritoneal Cancer1
2TerminatedTreatmentFallopian Tube Carcinoma / Ovarian Carcinoma / Primary Peritoneal Cancer1
2TerminatedTreatmentGlioblastoma Multiforme (GBM)2
2TerminatedTreatmentGlioblastoma Multiforme (GBM) / Gliosarcoma / Malignant Gliomas1
2TerminatedTreatmentHepatic Metastases / KRAS Wild Type Colorectal Cancer / Metastatic Colorectal Cancers1
2TerminatedTreatmentHepatic Metastases / Recurrent Colon Cancer / Recurrent Rectal Cancer / Stage IVA Colon Cancer / Stage IVA Rectal Cancer / Stage IVB Colon Cancer / Stage IVB Rectal Cancer1
2TerminatedTreatmentHepatocellular,Carcinoma1
2TerminatedTreatmentHigh-Grade Gliomas1
2TerminatedTreatmentIntracranial Meningioma1
2TerminatedTreatmentKeloid Scars1
2TerminatedTreatmentKidney (Renal Cell) Cancer / Neoplasms, Kidney1
2TerminatedTreatmentLoco-regional Esophageal Cancer1
2TerminatedTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)10
2TerminatedTreatmentLung Cancer Non-Small Cell Cancer (NSCLC) / Postmenopausal Women1
2TerminatedTreatmentLung Cancer Non-Small Cell Cancer (NSCLC) / Stage IIIA (N2)1
2TerminatedTreatmentLung Cancers4
2TerminatedTreatmentLymphoma, B-Cell / Non-Hodgkin's Lymphoma (NHL)1
2TerminatedTreatmentLymphoma, Hodgkins1
2TerminatedTreatmentMalignant Neoplasm of Colon1
2TerminatedTreatmentMalignant Neoplasm of Pancreas1
2TerminatedTreatmentMelanoma / Metastatic Melanoma1
2TerminatedTreatmentMetastatic Breast Cancer (MBC)4
2TerminatedTreatmentMetastatic Colon Cancer / Stage IV Rectal Cancer1
2TerminatedTreatmentMetastatic Colorectal Cancers2
2TerminatedTreatmentMetastatic Malignant Melanoma / Unresectable Malignant Melanoma1
2TerminatedTreatmentMetastatic Renal Cell Carcinoma1
2TerminatedTreatmentMultiple Myeloma (MM)1
2TerminatedTreatmentMyelodysplastic Syndromes1
2TerminatedTreatmentNeoplasms Metastasis / Neoplasms, Breast1
2TerminatedTreatmentNeoplasms, Colorectal4
2TerminatedTreatmentNon-Small Cell Lung Cancer Recurrent / Stage IIIb Non-small Cell Lung Cancer / Stage IV Non-Small Cell Lung Cancer1
2TerminatedTreatmentNon-Squamous Non-Small Cell Lung Cancer2
2TerminatedTreatmentPancreatic Cancer Metastatic1
2TerminatedTreatmentRectal Carcinoma1
2TerminatedTreatmentRenal Cancers2
2TerminatedTreatmentRenal Cell Adenocarcinoma3
2TerminatedTreatmentSarcomas / Soft Tissue Sarcoma (STS)1
2TerminatedTreatmentTriple Negative Metastatic Breast Cancer1
2Unknown StatusDiagnosticColorectal Cancers1
2Unknown StatusDiagnosticRecurrent Malignant Gliomas1
2Unknown StatusDiagnosticRenal Cancers1
2Unknown StatusPreventionBleb Fibrosis / Bleb Vascularity / Trabeculectomy Failure1
2Unknown StatusPreventionRetinal Detachment / Vitreoretinopathy, Proliferative1
2Unknown StatusPreventionVitreous Hemorrhage Secondary to PDR1
2Unknown StatusTreatmentBranch Retinal Vein Occlusion1
2Unknown StatusTreatmentCancer, Breast3
2Unknown StatusTreatmentCancer, Breast / Hormone-Sensitive Breast Cancer1
2Unknown StatusTreatmentCancer, Breast / Metastasis1
2Unknown StatusTreatmentColorectal Cancers4
2Unknown StatusTreatmentColorectal Cancers / Metastatic Cancers2
2Unknown StatusTreatmentCorneal Neovascularization1
2Unknown StatusTreatmentDiabetic Macular Edema (DME)1
2Unknown StatusTreatmentDiabetic Macular Edema (DME) / Non-Proliferative Diabetic Retinopathy / Proliferative Diabetic Retinopathy (PDR)1
2Unknown StatusTreatmentFibrosarcomas malignant / Fibrous Histiocytoma / Leiomyosarcomas / Liposarcoma / Soft Tissue Sarcoma (STS) / Synovial Sarcoma1
2Unknown StatusTreatmentGastric (Stomach) Cancer / Gastrointestinal Stromal Tumors (GISTs) / Malignant Neoplasm of Stomach / Neoplasm of Cardioesophageal Junction1
2Unknown StatusTreatmentGliomas1
2Unknown StatusTreatmentHemangiosarcoma / Soft Tissue Sarcoma (STS)1
2Unknown StatusTreatmentHepatocellular,Carcinoma1
2Unknown StatusTreatmentHereditary Haemorrhagic Telangiectasia (HHT)2
2Unknown StatusTreatmentIntraocular Melanoma1
2Unknown StatusTreatmentLocally Advanced Rectal Adenocarcinoma / Rectal Neoplasms1
2Unknown StatusTreatmentLocally Advanced Rectal Cancer1
2Unknown StatusTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)3
2Unknown StatusTreatmentLung Cancers2
2Unknown StatusTreatmentLung, Carcinoma1
2Unknown StatusTreatmentMacular Degeneration1
2Unknown StatusTreatmentMacular Edema (ME) / Retinopathy, Diabetic1
2Unknown StatusTreatmentMalignant Pleural Effusions1
2Unknown StatusTreatmentMetastatic Colorectal Cancers3
2Unknown StatusTreatmentMetastatic Renal Cell Carcinoma1
2Unknown StatusTreatmentNeoplasms, Brain1
2Unknown StatusTreatmentNeoplasms, Colorectal / Neoplasms, Hepatic1
2Unknown StatusTreatmentNeuroendocrine Carcinomas1
2Unknown StatusTreatmentOvarian Cancer With Malignant Ascites1
2Unknown StatusTreatmentProstate Cancer1
2Unknown StatusTreatmentRefractory Multiple Myeloma / Stage II Multiple Myeloma / Stage III Multiple Myeloma1
2Unknown StatusTreatmentRenal Cancers1
2Unknown StatusTreatmentRetinovascular Disease1
2Unknown StatusTreatmentUntreated Advanced Non-Small Cell Lung Cancer1
2WithdrawnPreventionAcute Respiratory Distress Syndrome (ARDS) / Severe Sepsis1
2WithdrawnPreventionMalignant Ascites1
2WithdrawnTreatmentAdenocarcinoma of the Colon / Adenocarcinoma of the Rectum / Recurrent Colon Cancer / Recurrent Rectal Cancer / Stage IVA Colon Cancer / Stage IVA Rectal Cancer / Stage IVB Colon Cancer / Stage IVB Rectal Cancer1
2WithdrawnTreatmentAdenocarcinoma of the Pancreas / Recurrent Pancreatic Cancer / Stage I Pancreatic Cancer / Stage II Pancreatic Cancer / Stage III Pancreatic Cancer1
2WithdrawnTreatmentAdrenocortical Carcinoma1
2WithdrawnTreatmentAdult Brain Glioblastoma / Recurrent Adult Brain Neoplasm1
2WithdrawnTreatmentB-Cell Chronic Lymphocytic Leukemia / Chronic Lymphocytic Leukemia (CLL) - Refractory1
2WithdrawnTreatmentCancer of the Ovary / Fallopian Tube Neoplasms / Primary Peritoneal1
2WithdrawnTreatmentCancer, Breast1
2WithdrawnTreatmentCervical Cancers1
2WithdrawnTreatmentColon Cancer Liver Metastasis1
2WithdrawnTreatmentColorectal Cancers3
2WithdrawnTreatmentColorectal Cancers / Metastatic Cancers2
2WithdrawnTreatmentGlioblastoma Multiforme (GBM)1
2WithdrawnTreatmentGlioblastomas1
2WithdrawnTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)1
2WithdrawnTreatmentLung Cancer Small Cell Lung Cancer (SCLC)1
2WithdrawnTreatmentLung Cancers1
2WithdrawnTreatmentMetastatic Colorectal Cancers2
2WithdrawnTreatmentNeoplasms, Colorectal1
2WithdrawnTreatmentNeoplasms, Head and Neck1
2WithdrawnTreatmentOesophageal Carcinoma1
2WithdrawnTreatmentRectal Cancer Patients1
2WithdrawnTreatmentRenal Cell Adenocarcinoma1
2WithdrawnTreatmentRetinopathy of Prematurity1
2WithdrawnTreatmentUnknown Primary Tumors1
2, 3Active Not RecruitingTreatmentCarcinoid tumour of the gastrointestinal tract / Islet Cell Tumor / Lung Cancers / Neoplastic Syndrome / Neuroendocrine Tumors1
2, 3CompletedDiagnosticColorectal Cancers1
2, 3CompletedTreatmentAdenocarcinoma of the Lung / Bronchoalveolar Cell Lung Cancer / Large Cell Lung Cancer / Non-Small Cell Lung Cancer Recurrent / Stage IIIb Non-small Cell Lung Cancer / Stage IV Non-Small Cell Lung Cancer1
2, 3CompletedTreatmentBrain Stem Gliomas / Cerebral Astrocytoma / Childhood Cerebellar Anaplastic Astrocytoma / Childhood Cerebral Anaplastic Astrocytoma / Childhood Spinal Cord Neoplasm / Untreated Childhood Brain Stem Glioma / Untreated Childhood Cerebral Astrocytoma1
2, 3CompletedTreatmentColorectal Cancers2
2, 3CompletedTreatmentCorneal Neovascularization1
2, 3CompletedTreatmentDiabetic Macular Edema (DME) / Macular Edema (ME)1
2, 3CompletedTreatmentGlaucoma3
2, 3CompletedTreatmentHER-2 Positive Breast Cancer / Inflammatory carcinoma of breast stage IV / Inflammatory carcinoma of the breast / Invasive Ductal Breast Carcinoma / Malignant Neoplasm of Female Breast / Mucinous Breast Cancer Stage II / Tubular Breast Cancer Stage II / Tubular Breast Cancer Stage III1
2, 3CompletedTreatmentMacular Degeneration1
2, 3CompletedTreatmentNon-Ischemic Central Retinal Vein Occlusion1
2, 3CompletedTreatmentProgression Free Survival1
2, 3CompletedTreatmentProliferative Diabetic Retinopathy (PDR)1
2, 3CompletedTreatmentRecurrent Pterygium1
2, 3Not Yet RecruitingTreatmentAbdominal wall neoplasm / Carcinoma, Colorectal / Colorectal Cancers / Colorectal Tumors / Neoplasms, Colorectal / Peritoneal Diseases1
2, 3Not Yet RecruitingTreatmentDiabetic Macular Edema (DME)1
2, 3RecruitingBasic ScienceAge Related Macular Degeneration (ARMD)1
2, 3RecruitingTreatmentAnaplastic Astrocytoma (AA) / Glioblastoma Multiforme (GBM)1
2, 3RecruitingTreatmentColorectal Cancers1
2, 3RecruitingTreatmentColorectal neoplasms malignant1
2, 3RecruitingTreatmentDiabetic Macular Edema (DME)2
2, 3RecruitingTreatmentFallopian Tube Clear Cell Adenocarcinoma / Fallopian Tube Endometrioid Adenocarcinoma / Fallopian Tube Undifferentiated Carcinoma / High Grade Fallopian Tube Serous Adenocarcinoma / High Grade Ovarian Serous Adenocarcinoma / Ovarian Clear Cell Adenocarcinoma / Ovarian Endometrioid Adenocarcinoma / Ovarian Seromucinous Carcinoma / Ovarian Undifferentiated Carcinoma / Primary Peritoneal High Grade Serous Adenocarcinoma / Recurrent Fallopian Tube Carcinoma / Recurrent Ovarian Carcinoma / Recurrent Primary Peritoneal Carcinoma / Undifferentiated Fallopian Tube Carcinoma / Undifferentiated Ovarian Carcinoma1
2, 3RecruitingTreatmentOesophagogastric Cancer1
2, 3RecruitingTreatmentRetinal Vein Occlusions(RVO)2
2, 3TerminatedTreatmentHereditary Haemorrhagic Telangiectasia (HHT) / Nasal Bleeding1
2, 3TerminatedTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)1
2, 3Unknown StatusNot AvailableMacular Edema (ME) / Retinopathy, Diabetic1
2, 3WithdrawnTreatmentCarcinoma, Colorectal / Hepatic Metastases1
3Active Not RecruitingTreatmentAbdominal wall neoplasm / Fallopian Tube Neoplasms / Genital Diseases, Female / Neoplasms, Ovarian / Ovarian Diseases1
3Active Not RecruitingTreatmentAdenocarcinoma of Lung Stage IV / Recurrent Large Cell Lung Carcinoma / Recurrent Lung Adenocarcinoma / Recurrent Squamous Cell Lung Carcinoma / Stage IV Large Cell Lung Carcinoma / Stage IV Squamous Cell Lung Carcinoma1
3Active Not RecruitingTreatmentAdenocarcinoma, Mucinous / Carcinoma, Undifferentiated / Clear Cell Adenocarcinoma / Fallopian Tube Clear Cell Adenocarcinoma / Fallopian Tube Endometrioid Adenocarcinoma / Fallopian Tube Mucinous Adenocarcinoma / Fallopian Tube Serous Adenocarcinoma / Fallopian Tube Undifferentiated Carcinoma / Malignant Ovarian Mixed Epithelial Tumor / Ovarian Brenner Tumor / Ovarian Clear Cell Adenocarcinofibroma / Ovarian Endometrioid Adenocarcinoma / Ovarian Seromucinous Carcinoma / Ovarian Serous Adenocarcinoma / Ovarian Undifferentiated Carcinoma / Primary Peritoneal Serous Adenocarcinoma / Recurrent Fallopian Tube Carcinoma / Recurrent Ovarian Carcinoma / Recurrent Primary Peritoneal Carcinoma / Undifferentiated Fallopian Tube Carcinoma / Undifferentiated Ovarian Carcinoma1
3Active Not RecruitingTreatmentAdvanced Non-Small Cell Lung Cancer1
3Active Not RecruitingTreatmentAge Related Macular Degeneration (ARMD)1
3Active Not RecruitingTreatmentAtypical Carcinoid Tumor / Carcinoid Tumors / Colorectal Neuroendocrine Tumor G1 / Gastric Neuroendocrine Tumor G1 / Neuroendocrine Carcinomas / Neuroendocrine Neoplasms1
3Active Not RecruitingTreatmentBladder Urothelial Carcinoma / Distal Urethral Carcinoma / Infiltrating Bladder Urothelial Carcinoma Associated With Urethral Carcinoma / Metastatic Bladder Cancer / Metastatic Urothelial Carcinoma of the Renal Pelvis and Ureter / Proximal Urethral Carcinoma / Recurrent Bladder Carcinoma / Recurrent Prostate Carcinoma / Recurrent Urethra Carcinoma / Recurrent Urethral Carcinoma / Recurrent Urothelial Carcinoma of the Renal Pelvis and Ureter / Regional Urothelial Carcinoma of the Renal Pelvis and Ureter / Stage IV Bladder Cancer AJCC v7 / Stage IV Prostate Cancer / Stage IV Prostate Cancer AJCC v7 / Stage IV Urethral Cancer / Stage IV Urethral Cancer AJCC v7 / Ureter Carcinoma1
3Active Not RecruitingTreatmentBorderline Ovarian Mucinous Tumor / Ovarian Mucinous Cystadenocarcinoma / Recurrent Fallopian Tube Carcinoma / Recurrent Ovarian Carcinoma / Stage IA Fallopian Tube Cancer / Stage IA Ovarian Cancer / Stage IB Fallopian Tube Cancer / Stage IB Ovarian Cancer / Stage IC Fallopian Tube Cancer / Stage IC Ovarian Cancer / Stage IIA Fallopian Tube Cancer / Stage IIA Ovarian Cancer / Stage IIB Fallopian Tube Cancer / Stage IIB Ovarian Cancer / Stage IIC Fallopian Tube Cancer / Stage IIC Ovarian Cancer / Stage IIIA Fallopian Tube Cancer / Stage IIIA Ovarian Cancer / Stage IIIB Fallopian Tube Cancer / Stage IIIB Ovarian Cancer / Stage IIIC Fallopian Tube Cancer / Stage IIIC Ovarian Cancer / Stage IV Fallopian Tube Cancer / Stage IV Ovarian Cancer1
3Active Not RecruitingTreatmentCancer, Breast3
3Active Not RecruitingTreatmentCarcinoma, Colorectal1
3Active Not RecruitingTreatmentCentral Retinal Vein Occlusion (CRVO)1
3Active Not RecruitingTreatmentChoroidal Subfoveal/Juxtafoveal Neovascularization in High Myopia1
3Active Not RecruitingTreatmentCognition Disorders / Disability Evaluation / Glioblastoma Multiforme (GBM)1
3Active Not RecruitingTreatmentColon Mucinous Adenocarcinoma / Colon Signet Ring Cell Adenocarcinoma / Lynch Syndrome / Stage IIA Colon Cancer / Stage IIA Colon Cancer AJCC v7 / Stage IIB Colon Cancer / Stage IIB Colon Cancer AJCC v7 / Stage IIC Colon Cancer / Stage IIC Colon Cancer AJCC v71
3Active Not RecruitingTreatmentColorectal Cancers3
3Active Not RecruitingTreatmentDiabetic Macular Edema (DME)1
3Active Not RecruitingTreatmentDigestive System Neoplasms / Intestinal Neoplasms / Neoplasms Metastasis / Neoplasms, Colorectal / Neoplasms, Gastrointestinal1
3Active Not RecruitingTreatmentEstrogen Receptor Negative / Estrogen Receptor Positive / HER2/Neu Negative / HER2/Neu Positive / Male Breast Carcinoma / Progesterone Receptor Negative / Progesterone Receptor Positive / Recurrent Breast Carcinoma / Stage IIIC Breast Cancer AJCC v6 / Stage IV Breast Cancer / Stage IV Breast Cancer AJCC v6 and v71
3Active Not RecruitingTreatmentEstrogen Receptor Negative / Estrogen Receptor Positive / HER2/Neu Negative / Male Breast Carcinoma / Stage IA Breast Cancer / Stage IB Breast Cancer / Stage IIA Breast Cancer / Stage IIB Breast Cancer / Stage IIIA Breast Cancer / Stage IIIB Breast Cancer / Stage IIIC Breast Cancer1
3Active Not RecruitingTreatmentEstrogen Receptor Positive / Progesterone Receptor Positive / Recurrent Breast Carcinoma / Stage IIIB Breast Cancer / Stage IV Breast Cancer1
3Active Not RecruitingTreatmentFallopian Tube Endometrioid Adenocarcinoma / Fallopian Tube Mucinous Adenocarcinoma / Fallopian Tube Transitional Cell Carcinoma / Malignant Ovarian Mixed Epithelial Tumor / Ovarian Brenner Tumor / Ovarian Clear Cell Adenocarcinofibroma / Ovarian Endometrioid Adenocarcinoma / Ovarian Mucinous Adenocarcinoma / Ovarian Serous Adenocarcinoma / Ovarian Transitional Cell Carcinoma / Primary Peritoneal Serous Adenocarcinoma / Stage IIA Fallopian Tube Cancer / Stage IIA Ovarian Cancer / Stage IIB Fallopian Tube Cancer / Stage IIB Ovarian Cancer / Stage IIC Fallopian Tube Cancer / Stage IIC Ovarian Cancer / Stage IIIA Fallopian Tube Cancer / Stage IIIA Ovarian Cancer / Stage IIIA Primary Peritoneal Cancer / Stage IIIB Fallopian Tube Cancer / Stage IIIB Ovarian Cancer / Stage IIIB Primary Peritoneal Cancer / Stage IIIC Fallopian Tube Cancer / Stage IIIC Ovarian Cancer / Stage IIIC Primary Peritoneal Cancer / Stage IV Fallopian Tube Cancer / Stage IV Ovarian Cancer / Stage IV Primary Peritoneal Cancer / Undifferentiated Ovarian Carcinoma1
3Active Not RecruitingTreatmentGlaucoma1
3Active Not RecruitingTreatmentGlioblastomas1
3Active Not RecruitingTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)5
3Active Not RecruitingTreatmentLung Cancer Non-Small Cell Cancer (NSCLC) / Lung Cancers1
3Active Not RecruitingTreatmentLung Cancer Non-Small Cell Cancer (NSCLC) / Non-Squamous Non-Small Cell Lung Cancer1
3Active Not RecruitingTreatmentLung Cancers1
3Active Not RecruitingTreatmentMalignant Ovarian Mixed Epithelial Tumor / Ovarian Brenner Tumor / Ovarian Clear Cell Cystadenocarcinoma / Ovarian Endometrioid Adenocarcinoma / Ovarian Mucinous Cystadenocarcinoma / Ovarian Serous Cystadenocarcinoma / Stage IIA Fallopian Tube Cancer / Stage IIA Ovarian Cancer / Stage IIB Fallopian Tube Cancer / Stage IIB Ovarian Cancer / Stage IIC Fallopian Tube Cancer / Stage IIC Ovarian Cancer / Stage IIIA Fallopian Tube Cancer / Stage IIIA Ovarian Cancer / Stage IIIA Primary Peritoneal Cancer / Stage IIIB Fallopian Tube Cancer / Stage IIIB Ovarian Cancer / Stage IIIB Primary Peritoneal Cancer / Stage IIIC Fallopian Tube Cancer / Stage IIIC Ovarian Cancer / Stage IIIC Primary Peritoneal Cancer / Undifferentiated Ovarian Carcinoma1
3Active Not RecruitingTreatmentMetastatic Colorectal Cancers3
3Active Not RecruitingTreatmentNon-Squamous Non-Small Cell Lung Cancer1
3Active Not RecruitingTreatmentRecurrent Glioblastoma1
3Active Not RecruitingTreatmentRecurrent Hypopharyngeal Squamous Cell Carcinoma / Recurrent Laryngeal Squamous Cell Carcinoma / Recurrent Laryngeal Verrucous Carcinoma / Recurrent Lip and Oral Cavity Squamous Cell Carcinoma / Recurrent Metastatic Squamous Cell Carcinoma in the Neck With Occult Primary / Recurrent Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma / Recurrent Oral Cavity Verrucous Carcinoma / Recurrent Oropharyngeal Squamous Cell Carcinoma / Recurrent Salivary Gland Carcinoma / Salivary Gland Squamous Cell Carcinoma / Squamous Cell Carcinoma Metastatic in the Neck With Occult Primary / Stage IV Hypopharyngeal Squamous Cell Carcinoma / Stage IV Hypopharyngeal Squamous Cell Carcinoma AJCC v7 / Stage IV Major Salivary Gland Cancer AJCC v7 / Stage IV Major Salivary Gland Carcinoma / Stage IVA Laryngeal Squamous Cell Carcinoma / Stage IVA Laryngeal Squamous Cell Carcinoma AJCC v7 / Stage IVA Laryngeal Verrucous Carcinoma / Stage IVA Laryngeal Verrucous Carcinoma AJCC v7 / Stage IVA Lip and Oral Cavity Squamous Cell Carcinoma / Stage IVA Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7 / Stage IVA Major Salivary Gland Cancer AJCC v7 / Stage IVA Major Salivary Gland Carcinoma / Stage IVA Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma / Stage IVA Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma AJCC v7 / Stage IVA Oral Cavity Cancer AJCC v6 and v7 / Stage IVA Oral Cavity Verrucous Carcinoma / Stage IVA Oropharyngeal Squamous Cell Carcinoma / Stage IVA Oropharyngeal Squamous Cell Carcinoma AJCC v7 / Stage IVB Laryngeal Squamous Cell Carcinoma / Stage IVB Laryngeal Squamous Cell Carcinoma AJCC v7 / Stage IVB Laryngeal Verrucous Carcinoma / Stage IVB Laryngeal Verrucous Carcinoma AJCC v7 / Stage IVB Lip and Oral Cavity Squamous Cell Carcinoma / Stage IVB Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7 / Stage IVB Major Salivary Gland Cancer AJCC v7 / Stage IVB Major Salivary Gland Carcinoma / Stage IVB Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma / Stage IVB Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma AJCC v7 / Stage IVB Oral Cavity Cancer AJCC v6 and v7 / Stage IVB Oral Cavity Verrucous Carcinoma / Stage IVB Oropharyngeal Squamous Cell Carcinoma / Stage IVB Oropharyngeal Squamous Cell Carcinoma AJCC v7 / Stage IVC Laryngeal Squamous Cell Carcinoma / Stage IVC Laryngeal Squamous Cell Carcinoma AJCC v7 / Stage IVC Laryngeal Verrucous Carcinoma / Stage IVC Laryngeal Verrucous Carcinoma AJCC v7 / Stage IVC Lip and Oral Cavity Squamous Cell Carcinoma / Stage IVC Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7 / Stage IVC Major Salivary Gland Cancer AJCC v7 / Stage IVC Major Salivary Gland Carcinoma / Stage IVC Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma / Stage IVC Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma AJCC v7 / Stage IVC Oral Cavity Cancer AJCC v6 and v7 / Stage IVC Oral Cavity Verrucous Carcinoma / Stage IVC Oropharyngeal Squamous Cell Carcinoma / Stage IVC Oropharyngeal Squamous Cell Carcinoma AJCC v7 / Tongue Carcinoma / Untreated Metastatic Squamous Cell Carcinoma to Neck With Occult Primary1
3Active Not RecruitingTreatmentRecurrent Ovarian Cancer1
3Active Not RecruitingTreatmentRecurrent Platinum-sensitive Ovarian Cancer1
3Active Not RecruitingTreatmentRenal Cell Adenocarcinoma1
3Active Not RecruitingTreatmentStage IB Non-Small Cell Lung Carcinoma / Stage IB Non-Small Cell Lung Carcinoma AJCC v7 / Stage IIA Non-Small Cell Lung Carcinoma / Stage IIA Non-Small Cell Lung Carcinoma AJCC v7 / Stage IIB Non-Small Cell Lung Carcinoma / Stage IIB Non-Small Cell Lung Carcinoma AJCC v7 / Stage IIIA Non-Small Cell Lung Cancer / Stage IIIA Non-Small Cell Lung Cancer AJCC v71
3CompletedNot AvailableDiabetic Macular Edema (DME)1
3CompletedPreventionCataracts / Cystoid Macular Edema / Diabetes Mellitus (DM)1
3CompletedSupportive CareCancers / Colorectal Cancers / Fevers / Locally Advanced / Malignant Neoplasm of Colon / Metastatic Colorectal Cancers / Neutropenias / Rectal Carcinoma1
3CompletedTreatmentAdenocarcinoma of the Cervix / Adenosquamous carcinoma of the cervix / Cervical Squamous Cell Carcinoma / Recurrent Cervical Carcinoma / Stage IVB Cervical Cancer1
3CompletedTreatmentAdenocarcinoma of the Colon / Adenocarcinoma of the Rectum / Metastatic Colon Cancer / Recurrent Colon Cancer / Recurrent Rectal Cancer / Stage III Colon Cancer / Stage III Rectal Cancer / Stage IV Rectal Cancer1
3CompletedTreatmentAdenocarcinoma of the Colon / Stage IIA Colon Cancer / Stage IIB Colon Cancer / Stage IIC Colon Cancer / Stage IIIA Colon Cancer / Stage IIIB Colon Cancer / Stage IIIC Colon Cancer1
3CompletedTreatmentAdenocarcinoma of the Pancreas / Recurrent Pancreatic Cancer / Stage II Pancreatic Cancer / Stage III Pancreatic Cancer / Stage IV Pancreatic Cancer1
3CompletedTreatmentAdenocarcinoma of the Prostate / Hormone-Resistant Prostate Cancer / Recurrent Prostate Cancer / Stage IV Prostate Cancer1
3CompletedTreatmentAdenocarcinomas1
3CompletedTreatmentAdult Giant Cell Glioblastoma / Adult Glioblastoma / Adult Gliosarcoma / Cognitive Side Effects of Cancer Therapy / Glioblastomas / Gliosarcoma / Supratentorial Glioblastoma1
3CompletedTreatmentAge Related Macular Degeneration (ARMD)2
3CompletedTreatmentAge-Related Macular Degeneration (ARMD)1
3CompletedTreatmentBranch Retinal Vein Occlusion1
3CompletedTreatmentCancer of the Ovary3
3CompletedTreatmentCancer of the Ovary / Fallopian Tube Cancer / Primary Peritoneal Cavity Cancer1
3CompletedTreatmentCancer, Breast8
3CompletedTreatmentCancer, Breast / Colorectal Cancers / Metastases1
3CompletedTreatmentCentral Retinal Vein Occlusion (CRVO)1
3CompletedTreatmentColorectal Cancers16
3CompletedTreatmentColorectal Cancers / Metastases1
3CompletedTreatmentDiabetic Macular Edema (DME)2
3CompletedTreatmentDiabetic Macular Edema (DME) / Proliferative Diabetic Retinopathy (PDR) / Retinopathy, Diabetic1
3CompletedTreatmentFallopian Tube Clear Cell Adenocarcinoma / Fallopian Tube Endometrioid Adenocarcinoma / Fallopian Tube Mucinous Adenocarcinoma / Fallopian Tube Serous Adenocarcinoma / Fallopian Tube Transitional Cell Carcinoma / Malignant Ovarian Mixed Epithelial Tumor / Ovarian Brenner Tumor / Ovarian Clear Cell Adenocarcinoma / Ovarian Endometrioid Adenocarcinoma / Ovarian Mucinous Adenocarcinoma / Ovarian Serous Adenocarcinoma / Ovarian Transitional Cell Carcinoma / Primary Peritoneal Serous Adenocarcinoma / Stage IIIA Fallopian Tube Cancer / Stage IIIA Ovarian Cancer / Stage IIIA Primary Peritoneal Cancer / Stage IIIB Fallopian Tube Cancer / Stage IIIB Ovarian Cancer / Stage IIIB Primary Peritoneal Cancer / Stage IIIC Fallopian Tube Cancer / Stage IIIC Ovarian Cancer / Stage IIIC Primary Peritoneal Cancer / Stage IV Fallopian Tube Cancer / Stage IV Ovarian Cancer / Stage IV Primary Peritoneal Cancer / Undifferentiated Fallopian Tube Carcinoma / Undifferentiated Ovarian Carcinoma1
3CompletedTreatmentGastrointestinal Stromal Tumors1
3CompletedTreatmentGlioblastomas1
3CompletedTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)2
3CompletedTreatmentLung Cancer Non-Small Cell Cancer (NSCLC) / Non-Squamous Non-Small Cell Lung Cancer1
3CompletedTreatmentMacular Edema (ME) / Retinal Vein Occlusions(RVO)1
3CompletedTreatmentMacular Edema (ME) / Retinopathy, Diabetic1
3CompletedTreatmentMalignant Neoplasm of Pancreas1
3CompletedTreatmentMalignant Neoplasm of Stomach1
3CompletedTreatmentMalignant Pleural Effusions1
3CompletedTreatmentMetastatic Breast Cancer (MBC)4
3CompletedTreatmentMetastatic Colorectal Cancers2
3CompletedTreatmentMetastatic Non-Small Cell Lung Cancer1
3CompletedTreatmentMultifocal Choroiditis / Serpiginous Choroiditis / Vogt Koyanagi Harada Disease1
3CompletedTreatmentMyopia / Subfoveal Choroidal Neovascularization1
3CompletedTreatmentNeoplasms, Breast1
3CompletedTreatmentNeoplasms, Colorectal3
3CompletedTreatmentNon-Squamous Non-Small Cell Lung Cancer5
3CompletedTreatmentProliferative Diabetic Retinopathy (PDR)1
3CompletedTreatmentRenal Cancers1
3CompletedTreatmentRenal Cell Adenocarcinoma2
3CompletedTreatmentRetinal Diseases1
3CompletedTreatmentRetinal Vein Occlusions(RVO)1
3CompletedTreatmentSubfoveal Choroidal Neovascularization1
3CompletedTreatmentTumors, Solid1
3Not Yet RecruitingPreventionRecurrent Ovarian Carcinoma1
3Not Yet RecruitingTreatmentAdenocarcinoma of the Lung1
3Not Yet RecruitingTreatmentCervical Cancers1
3Not Yet RecruitingTreatmentColorectal Cancers1
3Not Yet RecruitingTreatmentLung Cancer Non-Small Cell Cancer (NSCLC) / Lung Cancers1
3Not Yet RecruitingTreatmentOvarian Epithelial Cancer1
3Not Yet RecruitingTreatmentRenal Cell Adenocarcinoma1
3RecruitingOtherAdenocarcinoma of Lung Metastatic to Brain / Bevacizumab / Brain Radiotherapy / Cerebral Metastases / Cerebral Radiotherapy / Lung Cancer Non-Small Cell Cancer (NSCLC) / Metastatic Non-Small Cell Lung Cancer / Non Epidermoid1
3RecruitingTreatmentAbdominal wall neoplasm / Cancer of the Ovary / Fallopian Tube Cancer1
3RecruitingTreatmentCancer of the Ovary1
3RecruitingTreatmentCancer of the Ovary / Fallopian Tube Cancer / Primary Peritoneal Cancer1
3RecruitingTreatmentCarcinoma of the Cervix, Stage IVB1
3RecruitingTreatmentColorectal Adenocarcinoma / High-Frequency Microsatellite Instability / Mismatch Repair Deficiency / Stage IV Colorectal Cancer / Stage IV Colorectal Cancer AJCC v7 / Stage IVA Colorectal Cancer / Stage IVA Colorectal Cancer AJCC v7 / Stage IVB Colorectal Cancer / Stage IVB Colorectal Cancer AJCC v71
3RecruitingTreatmentColorectal Cancers1
3RecruitingTreatmentCorneal Newvessels1
3RecruitingTreatmentDiabetic Macular Edema (DME)1
3RecruitingTreatmentDigestive System Neoplasms / Intestinal Neoplasms / Neoplasms Metastasis / Neoplasms, Colorectal / Neoplasms, Gastrointestinal1
3RecruitingTreatmentGlioblastomas / Progression / Recurrences1
3RecruitingTreatmentHemorrhagic Hereditary Telangiectasia (HHT)1
3RecruitingTreatmentHepatocellular,Carcinoma1
3RecruitingTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)4
3RecruitingTreatmentLung Cancer Non-Small Cell Cancer (NSCLC) / Non Small Cell Lung Cancer Metastatic / Recurrent Non Small Cell Lung Cancer1
3RecruitingTreatmentMetastatic Colorectal Cancer (MCRC)1
3RecruitingTreatmentMetastatic Colorectal Cancers2
3RecruitingTreatmentNeoplasms, Colorectal1
3RecruitingTreatmentNon-Small Cell Lung Carcinoma (NSCLC)1
3RecruitingTreatmentNon-Squamous Non-Small Cell Lung Cancer1
3RecruitingTreatmentRecurrent Ovarian Carcinoma1
3TerminatedTreatmentAdenocarcinoma of the Colon / Adenocarcinoma of the Rectum / Metastatic Colon Cancer / Recurrent Colon Cancer / Recurrent Rectal Cancer / Stage III Colon Cancer / Stage III Rectal Cancer / Stage IV Rectal Cancer1
3TerminatedTreatmentAdenocarcinoma of the Rectum / Stage II Rectal Cancer / Stage III Rectal Cancer1
3TerminatedTreatmentAge-Related Macular Degeneration (ARMD)1
3TerminatedTreatmentCancer, Breast2
3TerminatedTreatmentCarcinoma, Breast / HER2/Neu Positive / Male Breast Carcinoma / Recurrent Breast Carcinoma / Stage IV Breast Cancer1
3TerminatedTreatmentClear Cell Renal Cell Carcinoma / Renal Cell Carcinoma Recurrent / Stage III Renal Cell Cancer / Stage III Renal Cell Cancer AJCC v7 / Stage IV Renal Cell Cancer / Stage IV Renal Cell Cancer AJCC V71
3TerminatedTreatmentCognitive/Functional Effects / Colorectal Cancers / Neurotoxicity1
3TerminatedTreatmentColorectal Cancers1
3TerminatedTreatmentColorectal Cancers / Hepatic Metastases1
3TerminatedTreatmentFirst Line Metastatic Breast Cancer1
3TerminatedTreatmentLymphoma, B-Cell1
3TerminatedTreatmentRecurrent Colon Cancer / Recurrent Rectal Cancer / Stage IVA Colon Cancer / Stage IVA Rectal Cancer / Stage IVB Colon Cancer / Stage IVB Rectal Cancer1
3TerminatedTreatmentRecurrent Uterine Corpus Sarcoma / Stage IIIA Uterine Sarcoma / Stage IIIB Uterine Sarcoma / Stage IIIC Uterine Sarcoma / Stage IVA Uterine Sarcoma / Stage IVB Uterine Sarcoma / Uterine Corpus Leiomyosarcoma1
3TerminatedTreatmentUveitis1
3Unknown StatusNot AvailableCystoid Macular Edema1
3Unknown StatusTreatmentAge Related Macular Degeneration (ARMD)2
3Unknown StatusTreatmentAge-Related Neovascular Macular Degeneration1
3Unknown StatusTreatmentCancer, Breast / Cardiac Toxicity / Perioperative/Postoperative Complications1
3Unknown StatusTreatmentChoroidal Neovascularisation / Polypoidal Choroidal Vasculopathy (PCV)1
3Unknown StatusTreatmentColorectal Cancers2
3Unknown StatusTreatmentColorectal Cancers / Neoplasms Metastasis1
3Unknown StatusTreatmentDiabetic Macular Edema (DME)3
3Unknown StatusTreatmentDiffuse Diabetic Macular Edema1
3Unknown StatusTreatmentInflammatory Reaction / Pterygium1
3Unknown StatusTreatmentMalignant Neoplasm of Colon / Metastatic Colorectal Cancers / Rectal Carcinoma1
3Unknown StatusTreatmentMetastatic Breast Cancer (MBC)1
3Unknown StatusTreatmentMetastatic Colorectal Cancers2
3Unknown StatusTreatmentNeovascular Age-Related Macular Degeneration1
3Unknown StatusTreatmentRetinopathy, Diabetic1
3Unknown StatusTreatmentTelangiectasias1
3WithdrawnTreatmentAge-Related Macular Degeneration (ARMD)1
3WithdrawnTreatmentColorectal Cancers1
3WithdrawnTreatmentRenal Cell Adenocarcinoma1
3WithdrawnTreatmentWet Age-Related Macular Degeneration1
4Active Not RecruitingTreatmentCancer of the Ovary1
4Active Not RecruitingTreatmentNeoplasms1
4Active Not RecruitingTreatmentRecurrent Pterygium1
4CompletedNot AvailableDiabetic Macular Edema (DME) / Retinopathy, Diabetic1
4CompletedNot AvailableMacular Degeneration1
4CompletedHealth Services ResearchAge-Related Macular Degeneration (ARMD)1
4CompletedOtherHER2/Neu-negative Carcinoma of Breast / Hormone Receptor Positive Malignant Neoplasm of Breast / Recurrent Breast Cancer1
4CompletedTreatmentAge Related Macular Degeneration (ARMD)1
4CompletedTreatmentAge-Related Macular Degeneration (ARMD)1
4CompletedTreatmentCancer, Breast2
4CompletedTreatmentColorectal Cancer, Neoplasm Metastasis / Colorectal Cancers1
4CompletedTreatmentColorectal Cancers2
4CompletedTreatmentColorectal Cancers / Neoplasms, Colorectal1
4CompletedTreatmentCorneal Neovascularization1
4CompletedTreatmentDiabetic Macular Edema (DME)4
4CompletedTreatmentDiabetic Traction Retinal Detachment / Proliferative Diabetic Retinopathy (PDR) / Vitreous Hemorrhage1
4CompletedTreatmentFibrosis / Glaucoma / Optic Neuropathies1
4CompletedTreatmentGlaucoma / Iris Neovascularization1
4CompletedTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)1
4CompletedTreatmentMacular Edema (ME)1
4CompletedTreatmentMacular Edema Caused by Retinal Vein Occlusion1
4CompletedTreatmentNeovascular Age-Related Macular Degeneration1
4CompletedTreatmentNon-Squamous Non-Small Cell Lung Cancer1
4CompletedTreatmentProliferative Diabetic Retinopathy (PDR)1
4CompletedTreatmentProliferative Diabetic Retinopathy (PDR) / Vitreous Hemorrhage1
4CompletedTreatmentPterygium1
4CompletedTreatmentRetinal Vein Occlusions(RVO)1
4CompletedTreatmentRetinopathy, Diabetic1
4Enrolling by InvitationTreatmentDiabetic Macular Edema (DME)1
4Not Yet RecruitingTreatmentCorneal Neovascularization1
4Not Yet RecruitingTreatmentPterygium of Conjunctiva and Cornea1
4RecruitingHealth Services ResearchMalignant Neoplasm of Colon / Unresectable Metastasis Originating in Colonic Cancer1
4RecruitingOtherEye Diseases / Premature Births / Retinal Diseases / Retinopathy of Prematurity Both Eyes / Type 1 Retinopathy of Prematurity Both Eyes1
4RecruitingTreatmentDiabetic Macular Edema (DME) / Ischemic Maculopathy1
4RecruitingTreatmentHemophilia / Synovitis1
4RecruitingTreatmentHereditary Haemorrhagic Telangiectasia (HHT) / Nasal Bleeding1
4RecruitingTreatmentMacular Edema (ME) / Retinal Neovascularization1
4TerminatedTreatmentColorectal Cancers1
4TerminatedTreatmentColorectal Cancers / Neoplasms Metastasis1
4Unknown StatusSupportive CareGlaucoma1
4Unknown StatusTreatmentBleb Vascularity / Conjunctival Scarring1
4Unknown StatusTreatmentCentral Retinal Vein Occlusion (CRVO) / Macular Edema (ME)1
4Unknown StatusTreatmentDiabetic Macular Edema (DME) / Non-Proliferative Diabetic Retinopathy / Proliferative Diabetic Retinopathy (PDR)1
4Unknown StatusTreatmentDiffuse Diabetic Macular Edema1
4Unknown StatusTreatmentLiver Metastasis / Malignant Neoplasm of Stomach1
4Unknown StatusTreatmentMacular Edema (ME)1
4WithdrawnTreatmentCancer, Breast2
Not AvailableActive Not RecruitingNot AvailableCancer of the Ovary1
Not AvailableActive Not RecruitingNot AvailableCancer, Breast / Metastatic Breast Cancer (MBC)1
Not AvailableActive Not RecruitingNot AvailableCancers1
Not AvailableActive Not RecruitingNot AvailableColorectal Cancers1
Not AvailableActive Not RecruitingTreatmentRadiation Necrosis1
Not AvailableCompletedNot AvailableAMD1
Not AvailableCompletedNot AvailableAdenocarcinoma of the Lung1
Not AvailableCompletedNot AvailableAnal Carcinoma / Malignant Neoplasm of Colon / Neoplasms, Colorectal / Rectal Carcinoma1
Not AvailableCompletedNot AvailableCancer, Breast1
Not AvailableCompletedNot AvailableCancers1
Not AvailableCompletedNot AvailableCancers / Endothelial Dysfunction / High Blood Pressure (Hypertension)1
Not AvailableCompletedNot AvailableCancers / High Blood Pressure (Hypertension)1
Not AvailableCompletedNot AvailableColorectal Cancers5
Not AvailableCompletedNot AvailableColorectal Liver Metastases1
Not AvailableCompletedNot AvailableLung Cancers2
Not AvailableCompletedNot AvailableMacular Edema (ME) / Retinal Vein Occlusions(RVO)1
Not AvailableCompletedNot AvailableMetastatic Colorectal Cancers2
Not AvailableCompletedNot AvailableNon-Squamous Non-Small Cell Lung Cancer1
Not AvailableCompletedNot AvailableNonsquamous Nonsmall Cell Neoplasm of Lung1
Not AvailableCompletedNot AvailableOvarian Epithelial Cancer1
Not AvailableCompletedNot AvailableRecurrent Pterygium1
Not AvailableCompletedNot AvailableRenal Cell Adenocarcinoma3
Not AvailableCompletedNot AvailableRetinopathy of Prematurity1
Not AvailableCompletedBasic ScienceClear Cell Renal Cell Carcinoma1
Not AvailableCompletedBasic ScienceGlioblastomas / Gliomas1
Not AvailableCompletedBasic ScienceProliferative Diabetic Retinopathy (PDR)1
Not AvailableCompletedHealth Services ResearchDiabetic Macular Edema (DME) / Exudative Macular Degeneration1
Not AvailableCompletedTreatmentAge-Related Macular Degeneration (ARMD)1
Not AvailableCompletedTreatmentAge-Related Macular Degeneration (ARMD) / Central Retinal Vein Occlusion (CRVO) / Diabetic Macular Edema (DME)1
Not AvailableCompletedTreatmentCancer of the Ovary / Fallopian Tubes Cancer / Malignant Peritoneal Neoplasm1
Not AvailableCompletedTreatmentCancer, Breast2
Not AvailableCompletedTreatmentCentral Retinal Vein Occlusion (CRVO) / Macular Edema (ME)1
Not AvailableCompletedTreatmentCentral Serous Chorioretinopathy (CSC)1
Not AvailableCompletedTreatmentColonic Neoplasms / Rectal Neoplasms1
Not AvailableCompletedTreatmentColorectal Cancers1
Not AvailableCompletedTreatmentColorectal Cancers / Liver Metastasis1
Not AvailableCompletedTreatmentCorneal Neovascularization1
Not AvailableCompletedTreatmentDiabetic Macular Edema (DME)1
Not AvailableCompletedTreatmentGlaucoma / Neovascular1
Not AvailableCompletedTreatmentHerpetic Keratopathy / Lipid Keratopathy / Penetrating Keratoplasty / Rosaceas1
Not AvailableCompletedTreatmentMacular Edema (ME) / Retinal Vein Occlusions(RVO)1
Not AvailableCompletedTreatmentMalignant Gliomas1
Not AvailableCompletedTreatmentMetastatic Colorectal Cancers1
Not AvailableCompletedTreatmentNeovascular Age-Related Macular Degeneration2
Not AvailableCompletedTreatmentProliferative Diabetic Retinopathy (PDR)1
Not AvailableCompletedTreatmentProliferative Diabetic Retinopathy (PDR) / Vitreous Hemorrhage1
Not AvailableCompletedTreatmentProstate Cancer1
Not AvailableCompletedTreatmentPterygium of the Conjunctiva and Cornea1
Not AvailableCompletedTreatmentRetinal Detachment / Retinopathy, Diabetic1
Not AvailableCompletedTreatmentRetinopathy, Diabetic1
Not AvailableCompletedTreatmentUveal Melanoma1
Not AvailableNot Yet RecruitingDiagnosticGlioma of Brain / Metastatic Brain Tumors / Metastatic Melanoma / Neoplasms, Brain1
Not AvailableNot Yet RecruitingDiagnosticLung Cancer Non-Small Cell Cancer (NSCLC)1
Not AvailableRecruitingNot AvailableCancer of the Ovary1
Not AvailableRecruitingNot AvailableElderly Metastatic Colorectal Cancer Patients1
Not AvailableRecruitingNot AvailableLung Cancer Non-Small Cell Cancer (NSCLC)1
Not AvailableRecruitingNot AvailableMetastatic Colorectal Cancers2
Not AvailableRecruitingNot AvailableMetastatic Colorectal Cancers / Quality of Life1
Not AvailableRecruitingDiagnosticRecurrent Glioblastoma1
Not AvailableRecruitingTreatmentMetastatic Colorectal Cancers1
Not AvailableRecruitingTreatmentMulti-organ Metastatic Colorectal Cancer1
Not AvailableTemporarily Not AvailableNot AvailableRetinopathy of Prematurity1
Not AvailableTerminatedNot AvailableCancer, Breast2
Not AvailableTerminatedNot AvailableColorectal Cancers / Hepatocellular Cancer / Lung Cancer Non-Small Cell Cancer (NSCLC) / Renal Cell Adenocarcinoma1
Not AvailableTerminatedNot AvailableGlioma Patients1
Not AvailableTerminatedBasic ScienceGlioblastomas1
Not AvailableTerminatedTreatmentMalignant Neoplasm of Colon1
Not AvailableUnknown StatusNot AvailableAge Related Macular Degeneration (ARMD)1
Not AvailableUnknown StatusNot AvailableBevacizumab / Cancer, Breast / Molecular Targeted Therapy / Neoadjuvant Chemotherapy1
Not AvailableUnknown StatusNot AvailableCancer, Breast / Metastatic1
Not AvailableUnknown StatusNot AvailableNeovascular Age Related Macular Degeneration1
Not AvailableUnknown StatusNot AvailableUnspecified Adult Solid Tumor, Protocol Specific / Unspecified Childhood Solid Tumor, Protocol Specific1
Not AvailableUnknown StatusPreventionRetinopathy, Diabetic1
Not AvailableUnknown StatusTreatmentCancer, Breast1
Not AvailableUnknown StatusTreatmentDiabetes Complications1
Not AvailableUnknown StatusTreatmentMacular Oedema / Proliferative Diabetic Retinopathy (PDR) / Wet AMD1
Not AvailableUnknown StatusTreatmentRetinal Detachment / Vitreoretinopathy Proliferative1
Not AvailableUnknown StatusTreatmentSubfoveal Choroidal Neovascularization1
Not AvailableWithdrawnBasic ScienceCorneal Neovascularization1
Not AvailableWithdrawnTreatmentAngioid Streaks / Central Serous Chorioretinopathy (CSC) / Multifocal Choroiditis / Myopia / Ocular Histoplasmosis Syndrome / Punctate Inner Choroidopathy (PIC) / Subfoveal Choroidal Neovascularization / Trauma, or Hereditary Eye Diseases1
Not AvailableWithdrawnTreatmentCancer, Breast1
Not AvailableWithdrawnTreatmentMalignant Neoplasm of Pancreas1
Not AvailableWithdrawnTreatmentShock, Septic1

Pharmacoeconomics

Manufacturers
  • Roche Pharmaceuticals
Packagers
  • F Hoffmann-La Roche Ltd.
  • Genentech Inc.
Dosage forms
FormRouteStrength
SolutionIntravenous25 mg
Injection, solutionIntravenous100 mg/4mL
Injection, solutionIntravenous400 mg/16mL
Prices
Unit descriptionCostUnit
Avastin 400 mg/16ml Solution 16ml Vial2786.78USD vial
Avastin 100 mg/4ml Solution 4ml Vial696.7USD vial
Avastin 100 mg/4 ml vial167.48USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2286330No2008-06-102018-04-03Canada
CA2145985No2003-09-162012-10-28Canada

Properties

State
Liquid
Experimental Properties
PropertyValueSource
melting point (°C)61 °C (FAB fragment), 71 °C (whole mAb)Vermeer, A.W.P. & Norde, W., Biophys. J. 78:394-404 (2000)

Taxonomy

Description
Not Available
Kingdom
Organic Compounds
Super Class
Organic Acids
Class
Carboxylic Acids and Derivatives
Sub Class
Amino Acids, Peptides, and Analogues
Direct Parent
Peptides
Alternative Parents
Not Available
Substituents
Not Available
Molecular Framework
Not Available
External Descriptors
Not Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
Yes
General Function
Vascular endothelial growth factor receptor binding
Specific Function
Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of...
Gene Name
VEGFA
Uniprot ID
P15692
Uniprot Name
Vascular endothelial growth factor A
Molecular Weight
27042.205 Da
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352]
  2. Gerber HP, Ferrara N: Pharmacology and pharmacodynamics of bevacizumab as monotherapy or in combination with cytotoxic therapy in preclinical studies. Cancer Res. 2005 Feb 1;65(3):671-80. [PubMed:15705858]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Not Available
Specific Function
Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent...
Gene Name
FCGR3B
Uniprot ID
O75015
Uniprot Name
Low affinity immunoglobulin gamma Fc region receptor III-B
Molecular Weight
26215.64 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Serine-type peptidase activity
Specific Function
C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.
Gene Name
C1R
Uniprot ID
P00736
Uniprot Name
Complement C1r subcomponent
Molecular Weight
80118.04 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Not Available
Specific Function
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proe...
Gene Name
C1QA
Uniprot ID
P02745
Uniprot Name
Complement C1q subcomponent subunit A
Molecular Weight
26016.47 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Not Available
Specific Function
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proe...
Gene Name
C1QB
Uniprot ID
P02746
Uniprot Name
Complement C1q subcomponent subunit B
Molecular Weight
26721.62 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Not Available
Specific Function
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proe...
Gene Name
C1QC
Uniprot ID
P02747
Uniprot Name
Complement C1q subcomponent subunit C
Molecular Weight
25773.56 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Not Available
Specific Function
Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as...
Gene Name
FCGR3A
Uniprot ID
P08637
Uniprot Name
Low affinity immunoglobulin gamma Fc region receptor III-A
Molecular Weight
29088.895 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Receptor signaling protein activity
Specific Function
High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses.
Gene Name
FCGR1A
Uniprot ID
P12314
Uniprot Name
High affinity immunoglobulin gamma Fc receptor I
Molecular Weight
42631.525 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Not Available
Specific Function
Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized ...
Gene Name
FCGR2A
Uniprot ID
P12318
Uniprot Name
Low affinity immunoglobulin gamma Fc region receptor II-a
Molecular Weight
35000.42 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Not Available
Specific Function
Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complex...
Gene Name
FCGR2B
Uniprot ID
P31994
Uniprot Name
Low affinity immunoglobulin gamma Fc region receptor II-b
Molecular Weight
34043.355 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Transmembrane signaling receptor activity
Specific Function
Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulat...
Gene Name
FCGR2C
Uniprot ID
P31995
Uniprot Name
Low affinity immunoglobulin gamma Fc region receptor II-c
Molecular Weight
35577.96 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]

Drug created on June 13, 2005 07:24 / Updated on October 16, 2018 08:23