Name
Quinones
Accession Number
DBCAT000386
Description

Hydrocarbon rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.

Drugs
DrugDrug Description
MenadioneThe primary known function of vitamin K is to assist in the normal clotting of blood, but it may also play a role in normal bone calcification.
PhylloquinoneA fat soluble vitamin used to treat hemorrhagic conditions in infants and coumarin overdoses.
AtovaquoneAn antimicrobial indicated for the prevention and treatment of Pneumocystis jirovecii pneumonia (PCP) and for the prevention and treatment of Plasmodium falciparum malaria.
MitoxantroneA chemotherapeutic agent used for the treatment of secondary progressive, progressive relapsing, or worsening relapsing-remitting multiple sclerosis.
Nanaomycin DNot Available
DuroquinoneNot Available
GeldanamycinNot Available
DibromothymoquinoneAt low concentrations, this compound inhibits reduction of conventional hydrophilic electron acceptors, probably acting as a plastoquinone antagonist. At higher concentrations, it acts as an electron acceptor, intercepting electrons either...
LawsoneNot Available
DantronWithdrawn from the Canadian, US, and UK markets in 1998 due to genotoxicity.
BanoxantroneFor the treatment of various forms of cancer.
MitoquinoneInvestigated for use/treatment in hepatitis (viral, C) and parkinson's disease.
TanespimycinInvestigated for use/treatment in leukemia (myeloid) and solid tumors.
RetaspimycinInvestigated for use/treatment in gastric cancer, lung cancer, and multiple myeloma.
PorfiromycinInvestigated for use/treatment in head and neck cancer.
SeratrodastSeratrodast (INN) is a thromboxane receptor antagonist used primarily in the treatment of asthma.
BW-A 58CBW-A 58C, also known as 2-(4-tert-butylcyclohexyl)-3-hydroxy-1,4-naphthoquinone, is an experimental naphthoquinone antimalarial drug which undergoes extensive alkyl hydroxylation to a single t-butylhydroxy metabolite in man in vivo and also in human...
2,3-Dimethyl-1,4-naphthoquinoneNot Available
Ubiquinone Q2Not Available
IdebenoneAn analogue of ubiquinone used for the treatment of visual impairment in adolescent and adult patients with Leber’s Hereditary Optic Neuropathy (LHON).
UbidecarenoneA cofactor found in various dietary supplements.
TriethoxycaprylylsilaneNot Annotated
UbiquinolUbiquinol (CoQH2) is a reduced form of coenzyme Q10 (CoQ10) that acts as an active antioxidant that prevents the initiation and propagation of lipid peroxidation in biological membranes and human...
SennosidesA laxative used to treat constipation.
VatiquinoneVatiquinone has been investigated for the treatment and prevention of Retinopathy, Rett Syndrome, Genetic Disease, Noise-induced Hearing Loss, and Methylmalonic Aciduria and Homocystinuria,Cblc Type.
DiacereinFor the treatment of osteoarthritis affecting the hip or knee .
MenatetrenoneMenatetrenone has been used in trials studying the treatment of Diabetes, Osteoporosis, Prediabetic State, and Hepatocellular Carcinoma.
AntroquinonolAntroquinonol has been used in trials studying the treatment of Hyperlipidemias, Non-small Cell Lung Cancer, and Non-small Cell Lung Cancer Stage IV.
AlvespimycinInvestigated for use as an antineoplastic agent for solid tumors, advanced solid tumours or acute myeloid leukaemia.
TU-100TU-100 has been used in trials studying the treatment of Abdominal Pain, Colonic Transit, Crohn's Disease, Rectal Sensation, and Gastric Emptying, among others.
ApaziquoneApaziquone has been investigated for the treatment of Bladder Cancer and Bladder Neoplasms.
IPI-493IPI-493 has been used in trials studying the treatment of Advanced Malignancies.
Menaquinone 7Menaquinone 7 is under investigation in clinical trial NCT00402974 (The Effect of Vitamin K Supplementation on Osteocalcin Carboxylation in Healthy Children).
RheinNo approved indication.
IprazochromeNot Annotated
CarboquoneNot Annotated
NaftazoneNot Annotated
Menadiol diphosphateNot Annotated
EmodinEmodin has been investigated for the treatment of Polycystic Kidney.
LapachoneLapachone has been used in trials studying the treatment of Cancer, Carcinoma, Advanced Solid Tumors, Head and Neck Neoplasms, and Carcinoma, Squamous Cell.
Menaquinone 6Menaquinone 6 is under investigation in clinical trial NCT01194778 (Comparison of Efficacy of Different Dosages Vitamin K2).
MenaquinoneMenaquinone is under investigation in clinical trial NCT01533441 (Vitamin K2 Intervention in Patients With Vitamin K Antagonists).
NapabucasinNapabucasin has been investigated for the treatment of Colorectal Carcinoma.
AlloinNot Annotated
Frangula purshiana barkNot Annotated
FlaviolinNot Available
QuinalizarinNot Available
Ubiquinone Q1Not Available
OchromycinoneOchromycinone is under investigation in clinical trial NCT01047943 (STA-21 Topical Efficacy on Psoriasis).
2,3-dichloro-5,6-dicyanobenzoquinoneNot Annotated
Drugs & Drug Targets
DrugTargetType
MenadioneProthrombintarget
MenadioneVitamin K epoxide reductase complex subunit 1target
MenadioneCoagulation factor IXtarget
MenadioneVitamin K-dependent gamma-carboxylasetarget
MenadioneVitamin K-dependent protein Ctarget
MenadioneVitamin K-dependent protein Starget
MenadioneNAD(P)H dehydrogenase [quinone] 1target
MenadioneRibosyldihydronicotinamide dehydrogenase [quinone]target
MenadioneVitamin K epoxide reductase complex subunit 1-like protein 1target
MenadioneXanthine dehydrogenase/oxidaseenzyme
MenadioneAldehyde oxidaseenzyme
MenadioneMethylenetetrahydrofolate reductaseenzyme
MenadioneCytochrome P450 1A1enzyme
MenadioneOsteocalcintarget
MenadioneCytochrome P450 1A2enzyme
MenadioneCytochrome P450 2A6enzyme
PhylloquinoneVitamin K-dependent gamma-carboxylasetarget
PhylloquinoneOsteocalcintarget
AtovaquoneDihydroorotate dehydrogenase (quinone), mitochondrialtarget
AtovaquoneDihydroorotate dehydrogenase (quinone), mitochondrialtarget
AtovaquoneCytochrome btarget
AtovaquoneCytochrome P450 2C9enzyme
AtovaquoneCytochrome P450 3A4enzyme
AtovaquoneP-glycoprotein 1transporter
MitoxantroneDNA topoisomerase 2-alphatarget
MitoxantroneCytochrome P450 2E1enzyme
MitoxantroneP-glycoprotein 1transporter
MitoxantroneMultidrug resistance-associated protein 1transporter
MitoxantroneATP-binding cassette sub-family G member 2transporter
MitoxantroneDNAtarget
MitoxantroneCytochrome P450 1B1enzyme
MitoxantroneCytochrome P450 3A4enzyme
Nanaomycin DActVA 6 proteintarget
DuroquinoneNAD(P)H dehydrogenase [quinone] 1target
GeldanamycinHeat shock protein HSP 90-alphatarget
GeldanamycinHeat shock protein HSP 90-betatarget
GeldanamycinEndoplasmintarget
DibromothymoquinoneCytochrome b6target
DibromothymoquinoneCytochrome b6-f complex iron-sulfur subunittarget
DibromothymoquinoneCytochrome b6-f complex subunit 4target
DibromothymoquinoneApocytochrome ftarget
DibromothymoquinoneCytochrome b6-f complex subunit 5target
DibromothymoquinoneCytochrome b6-f complex subunit 6target
DibromothymoquinoneCytochrome b6-f complex subunit 7target
DibromothymoquinoneCytochrome b6-f complex subunit 8target
DantronSerum albumincarrier
BanoxantroneDNA topoisomerase 2-alphatarget
BanoxantroneCytochrome P450 3A4enzyme
BanoxantroneCytochrome P450 1A1enzyme
BanoxantroneCytochrome P450 2B6enzyme
TanespimycinHeat shock protein HSP 90-alphatarget
TanespimycinHeat shock protein HSP 90-betatarget
TanespimycinSerum albumincarrier
PorfiromycinXanthine dehydrogenase/oxidaseenzyme
SeratrodastCytochrome P450 2C9enzyme
SeratrodastCytochrome P450 3A4enzyme
SeratrodastCytochrome P450 2C8enzyme
SeratrodastCytochrome P450 2C19enzyme
SeratrodastCytochrome P450 2B6enzyme
SeratrodastUDP-glucuronosyltransferase 1-9enzyme
SeratrodastProstaglandin G/H synthase 1enzyme
SeratrodastCytochrome P450 2A6enzyme
SeratrodastThromboxane A2 receptortarget
2,3-Dimethyl-1,4-naphthoquinoneFumarate reductase flavoprotein subunittarget
2,3-Dimethyl-1,4-naphthoquinoneFumarate reductase iron-sulfur subunittarget
2,3-Dimethyl-1,4-naphthoquinoneFumarate reductase cytochrome b subunittarget
Ubiquinone Q2Succinate dehydrogenase flavoprotein subunittarget
Ubiquinone Q2Succinate dehydrogenase iron-sulfur subunittarget
Ubiquinone Q2Succinate dehydrogenase cytochrome b556 subunittarget
Ubiquinone Q2Succinate dehydrogenase hydrophobic membrane anchor subunittarget
Ubiquinone Q2Cytochrome c1, heme protein, mitochondrialtarget
Ubiquinone Q2Cytochrome btarget
Ubiquinone Q2Cytochrome b-c1 complex subunit 1, mitochondrialtarget
Ubiquinone Q2Cytochrome b-c1 complex subunit 2, mitochondrialtarget
Ubiquinone Q2Cytochrome b-c1 complex subunit 6, mitochondrialtarget
Ubiquinone Q2Cytochrome b-c1 complex subunit 8target
Ubiquinone Q2Cytochrome b-c1 complex subunit Rieske, mitochondrialtarget
Ubiquinone Q2Cytochrome b-c1 complex subunit 10target
Ubiquinone Q2Cytochrome b-c1 complex subunit 7target
Ubiquinone Q2Cytochrome b-c1 complex subunit 9target
Ubiquinone Q2Photosynthetic reaction center cytochrome c subunittarget
Ubiquinone Q2Reaction center protein H chaintarget
Ubiquinone Q2Reaction center protein L chaintarget
Ubiquinone Q2Reaction center protein M chaintarget
Ubiquinone Q2Disulfide bond formation protein Btarget
Ubiquinone Q2Cytochrome btarget
Ubiquinone Q2Ubiquinol-cytochrome c reductase iron-sulfur subunittarget
Ubiquinone Q2Cytochrome c1target
Ubiquinone Q2Reaction center protein L chaintarget
Ubiquinone Q2Reaction center protein M chaintarget
Ubiquinone Q2Reaction center protein H chaintarget
UbidecarenoneNADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrialtarget
UbidecarenoneSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialtarget
UbidecarenoneLow-density lipoprotein receptorcarrier
UbidecarenoneVery low-density lipoprotein receptorcarrier
UbidecarenoneP-glycoprotein 1transporter
Ubidecarenone3-hydroxy-3-methylglutaryl-coenzyme A reductaseenzyme
SennosidesReverse transcriptase/RNaseHtarget
SennosidesAquaporin-3target
DiacereinOxysterols receptor LXR-alphatarget
DiacereinOxysterols receptor LXR-betatarget
DiacereinArylamine N-acetyltransferasetarget
DiacereinArachidonate 5-lipoxygenasetarget
DiacereinCytochrome P450 1A2target
DiacereinCytochrome P450 3A Subfamilytarget
DiacereinCytochrome P450 2E1target
DiacereinCytochrome P450 2C9target
DiacereinCytochrome P450 2D6target
AlvespimycinHeat shock protein HSP 90-alphatarget
RheinOxysterols receptor LXR-alphatarget
RheinOxysterols receptor LXR-betatarget
RheinArylamine N-acetyltransferasetarget
RheinArachidonate 5-lipoxygenasetarget
RheinCytochrome P450 1A2enzyme
RheinCytochrome P450 3A Subfamilyenzyme
RheinCytochrome P450 2E1enzyme
RheinCytochrome P450 2C9enzyme
RheinCytochrome P450 2D6enzyme
EmodinCasein kinase II subunit alphatarget
EmodinPutative ketoacyl reductasetarget
Emodin3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZtarget
EmodinAryl hydrocarbon receptortarget
LapachoneRetinol-binding protein 3target
FlaviolinPutative cytochrome P450target
FlaviolinPrenyltransferasetarget
QuinalizarinCasein kinase II subunit alphatarget
Ubiquinone Q1Photosynthetic reaction center cytochrome c subunittarget
Ubiquinone Q1Reaction center protein H chaintarget
Ubiquinone Q1Reaction center protein L chaintarget
Ubiquinone Q1Reaction center protein M chaintarget
Ubiquinone Q1Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialtarget
Ubiquinone Q1Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialtarget
Ubiquinone Q1Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrialtarget
Ubiquinone Q1Succinate dehydrogenase cytochrome b560 subunit, mitochondrialtarget
Ubiquinone Q1Thiol:disulfide interchange protein DsbAtarget
Ubiquinone Q1Disulfide bond formation protein Btarget
Ubiquinone Q1NrfC proteintarget
Ubiquinone Q1Thiosulfate reductasetarget
Ubiquinone Q1Hypothetical membrane spanning proteintarget