Hydrocarbon rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.
DrugDrug NameDrug Description
DB00170MenadioneThe primary known function of vitamin K is to assist in the normal clotting of blood, but it may also play a role in normal bone calcification.
DB00305MitomycinAn antimetabolite used as an adjunct to ab externo (outside approach) eye surgeries for the treatment of glaucoma and used as a chemotherapeutic agent for various malignancies.
DB01022PhylloquinoneA fat soluble vitamin used to treat hemorrhagic conditions in infants and coumarin overdoses.
DB01117AtovaquoneAn antimicrobial indicated for the prevention and treatment of Pneumocystis jirovecii pneumonia (PCP) and for the prevention and treatment of Plasmodium falciparum malaria.
DB01204MitoxantroneA chemotherapeutic agent used for the treatment of secondary progressive, progressive relapsing, or worsening relapsing-remitting multiple sclerosis.
DB01668Nanaomycin DNot Available
DB01927DuroquinoneNot Available
DB02424GeldanamycinNot Available
DB04646DibromothymoquinoneAt low concentrations, this compound inhibits reduction of conventional hydrophilic electron acceptors, probably acting as a plastoquinone antagonist. At higher concentrations, it acts as an electron acceptor, intercepting electrons either...
DB04744LawsoneNot Available
DB04816DantronWithdrawn from the Canadian, US, and UK markets in 1998 due to genotoxicity.
DB04975BanoxantroneFor the treatment of various forms of cancer.
DB05063MitoquinoneInvestigated for use/treatment in hepatitis (viral, C) and parkinson's disease.
DB05134TanespimycinInvestigated for use/treatment in leukemia (myeloid) and solid tumors.
DB05626RetaspimycinInvestigated for use/treatment in gastric cancer, lung cancer, and multiple myeloma.
DB06478PorfiromycinInvestigated for use/treatment in head and neck cancer.
DB06739SeratrodastSeratrodast (INN) is a thromboxane receptor antagonist used primarily in the treatment of asthma.
DB06740BW-A 58CBW-A 58C, also known as 2-(4-tert-butylcyclohexyl)-3-hydroxy-1,4-naphthoquinone, is an experimental naphthoquinone antimalarial drug which undergoes extensive alkyl hydroxylation to a single t-butylhydroxy metabolite in man in vivo and also in human...
DB076692,3-Dimethyl-1,4-naphthoquinoneNot Available
DB08690Ubiquinone Q2Not Available
DB09081IdebenoneAn analogue of ubiquinone used for the treatment of visual impairment in adolescent and adult patients with Leber’s Hereditary Optic Neuropathy (LHON).
DB09270UbidecarenoneA cofactor found in various dietary supplements.
DB11267TriethoxycaprylylsilaneNot Annotated
DB11340UbiquinolUbiquinol (CoQH2) is a reduced form of coenzyme Q10 (CoQ10) that acts as an active antioxidant that prevents the initiation and propagation of lipid peroxidation in biological membranes and human...
DB11365SennosidesA laxative used to treat constipation.
DB11917VatiquinoneVatiquinone has been investigated for the treatment and prevention of Retinopathy, Rett Syndrome, Genetic Disease, Noise-induced Hearing Loss, and Methylmalonic Aciduria and Homocystinuria,Cblc Type.
DB11994DiacereinFor the treatment of osteoarthritis affecting the hip or knee .
DB12148MenatetrenoneMenatetrenone has been used in trials studying the treatment of Diabetes, Osteoporosis, Prediabetic State, and Hepatocellular Carcinoma.
DB12326AntroquinonolAntroquinonol has been used in trials studying the treatment of Hyperlipidemias, Non-small Cell Lung Cancer, and Non-small Cell Lung Cancer Stage IV.
DB12442AlvespimycinInvestigated for use as an antineoplastic agent for solid tumors, advanced solid tumours or acute myeloid leukaemia.
DB12467TU-100TU-100 has been used in trials studying the treatment of Abdominal Pain, Colonic Transit, Crohn's Disease, Rectal Sensation, and Gastric Emptying, among others.
DB12593ApaziquoneApaziquone has been investigated for the treatment of Bladder Cancer and Bladder Neoplasms.
DB13023IPI-493IPI-493 has been used in trials studying the treatment of Advanced Malignancies.
DB13075Menaquinone 7Menaquinone 7 is under investigation in clinical trial NCT00402974 (The Effect of Vitamin K Supplementation on Osteocalcin Carboxylation in Healthy Children).
DB13174RheinNo approved indication.
DB13541IprazochromeNot Annotated
DB13677CarboquoneNot Annotated
DB13680NaftazoneNot Annotated
DB14650Menadiol diphosphateNot Annotated
DB07715EmodinEmodin has been investigated for the treatment of Polycystic Kidney.
DB11948LapachoneLapachone has been used in trials studying the treatment of Cancer, Carcinoma, Advanced Solid Tumors, Head and Neck Neoplasms, and Carcinoma, Squamous Cell.
DB14936Menaquinone 6Menaquinone 6 is under investigation in clinical trial NCT01194778 (Comparison of Efficacy of Different Dosages Vitamin K2).
DB15381MenaquinoneMenaquinone is under investigation in clinical trial NCT01533441 (Vitamin K2 Intervention in Patients With Vitamin K Antagonists).
DB12155NapabucasinNapabucasin has been investigated for the treatment of Colorectal Carcinoma.
DB15477AlloinNot Annotated
DB15478Frangula purshiana barkNot Annotated
DB02521FlaviolinNot Available
DB08660QuinalizarinNot Available
DB08689Ubiquinone Q1Not Available
DrugDrug NameTargetType
DB00170MenadioneVitamin K-dependent protein Ztarget
DB00170MenadioneProthrombintarget
DB00170MenadioneVitamin K epoxide reductase complex subunit 1target
DB00170MenadioneCoagulation factor IXtarget
DB00170MenadioneCoagulation factor VIItarget
DB00170MenadioneCoagulation factor Xtarget
DB00170MenadioneVitamin K-dependent gamma-carboxylasetarget
DB00170MenadioneVitamin K-dependent protein Ctarget
DB00170MenadioneVitamin K-dependent protein Starget
DB00170MenadioneNAD(P)H dehydrogenase [quinone] 1target
DB00170MenadioneRibosyldihydronicotinamide dehydrogenase [quinone]target
DB00170MenadioneVitamin K epoxide reductase complex subunit 1-like protein 1target
DB00170MenadioneXanthine dehydrogenase/oxidaseenzyme
DB00170MenadioneAldehyde oxidaseenzyme
DB00170MenadioneMethylenetetrahydrofolate reductaseenzyme
DB00170MenadioneCytochrome P450 1A1enzyme
DB00170MenadioneOsteocalcintarget
DB00170MenadioneCytochrome P450 1A2enzyme
DB00170MenadioneCytochrome P450 2A6enzyme
DB00305MitomycinDNAtarget
DB00305MitomycinNADPH--cytochrome P450 reductaseenzyme
DB01022PhylloquinoneVitamin K-dependent gamma-carboxylasetarget
DB01022PhylloquinoneOsteocalcintarget
DB01117AtovaquoneDihydroorotate dehydrogenase (quinone), mitochondrialtarget
DB01117AtovaquoneDihydroorotate dehydrogenase (quinone), mitochondrialtarget
DB01117AtovaquoneCytochrome btarget
DB01117AtovaquoneCytochrome P450 2C9enzyme
DB01117AtovaquoneCytochrome P450 3A4enzyme
DB01117AtovaquoneP-glycoprotein 1transporter
DB01204MitoxantroneDNA topoisomerase 2-alphatarget
DB01204MitoxantroneCytochrome P450 2E1enzyme
DB01204MitoxantroneP-glycoprotein 1transporter
DB01204MitoxantroneMultidrug resistance-associated protein 1transporter
DB01204MitoxantroneATP-binding cassette sub-family G member 2transporter
DB01204MitoxantroneDNAtarget
DB01204MitoxantroneCytochrome P450 1B1enzyme
DB01204MitoxantroneCytochrome P450 3A4enzyme
DB01668Nanaomycin DActVA 6 proteintarget
DB01927DuroquinoneNAD(P)H dehydrogenase [quinone] 1target
DB02424GeldanamycinHeat shock protein HSP 90-alphatarget
DB02424GeldanamycinHeat shock protein HSP 90-betatarget
DB02424GeldanamycinEndoplasmintarget
DB04646DibromothymoquinoneCytochrome b6target
DB04646DibromothymoquinoneCytochrome b6-f complex iron-sulfur subunittarget
DB04646DibromothymoquinoneCytochrome b6-f complex subunit 4target
DB04646DibromothymoquinoneApocytochrome ftarget
DB04646DibromothymoquinoneCytochrome b6-f complex subunit 5target
DB04646DibromothymoquinoneCytochrome b6-f complex subunit 6target
DB04646DibromothymoquinoneCytochrome b6-f complex subunit 7target
DB04646DibromothymoquinoneCytochrome b6-f complex subunit 8target
DB04816DantronSerum albumincarrier
DB04975BanoxantroneDNA topoisomerase 2-alphatarget
DB04975BanoxantroneCytochrome P450 3A4enzyme
DB04975BanoxantroneCytochrome P450 1A1enzyme
DB04975BanoxantroneCytochrome P450 2B6enzyme
DB05134TanespimycinHeat shock protein HSP 90-alphatarget
DB05134TanespimycinHeat shock protein HSP 90-betatarget
DB05134TanespimycinSerum albumincarrier
DB06478PorfiromycinXanthine dehydrogenase/oxidaseenzyme
DB06739SeratrodastCytochrome P450 2C9enzyme
DB06739SeratrodastCytochrome P450 3A4enzyme
DB06739SeratrodastCytochrome P450 2C8enzyme
DB06739SeratrodastCytochrome P450 2C19enzyme
DB06739SeratrodastCytochrome P450 2B6enzyme
DB06739SeratrodastUDP-glucuronosyltransferase 1-9enzyme
DB06739SeratrodastProstaglandin G/H synthase 1enzyme
DB06739SeratrodastCytochrome P450 2A6enzyme
DB06739SeratrodastThromboxane A2 receptortarget
DB076692,3-Dimethyl-1,4-naphthoquinoneFumarate reductase flavoprotein subunittarget
DB076692,3-Dimethyl-1,4-naphthoquinoneFumarate reductase iron-sulfur subunittarget
DB076692,3-Dimethyl-1,4-naphthoquinoneFumarate reductase cytochrome b subunittarget
DB08690Ubiquinone Q2Succinate dehydrogenase flavoprotein subunittarget
DB08690Ubiquinone Q2Succinate dehydrogenase iron-sulfur subunittarget
DB08690Ubiquinone Q2Succinate dehydrogenase cytochrome b556 subunittarget
DB08690Ubiquinone Q2Succinate dehydrogenase hydrophobic membrane anchor subunittarget
DB08690Ubiquinone Q2Cytochrome c1, heme protein, mitochondrialtarget
DB08690Ubiquinone Q2Cytochrome btarget
DB08690Ubiquinone Q2Cytochrome b-c1 complex subunit 1, mitochondrialtarget
DB08690Ubiquinone Q2Cytochrome b-c1 complex subunit 2, mitochondrialtarget
DB08690Ubiquinone Q2Cytochrome b-c1 complex subunit 6, mitochondrialtarget
DB08690Ubiquinone Q2Cytochrome b-c1 complex subunit 8target
DB08690Ubiquinone Q2Cytochrome b-c1 complex subunit Rieske, mitochondrialtarget
DB08690Ubiquinone Q2Cytochrome b-c1 complex subunit 10target
DB08690Ubiquinone Q2Cytochrome b-c1 complex subunit 7target
DB08690Ubiquinone Q2Cytochrome b-c1 complex subunit 9target
DB08690Ubiquinone Q2Photosynthetic reaction center cytochrome c subunittarget
DB08690Ubiquinone Q2Reaction center protein H chaintarget
DB08690Ubiquinone Q2Reaction center protein L chaintarget
DB08690Ubiquinone Q2Reaction center protein M chaintarget
DB08690Ubiquinone Q2Disulfide bond formation protein Btarget
DB08690Ubiquinone Q2Cytochrome btarget
DB08690Ubiquinone Q2Ubiquinol-cytochrome c reductase iron-sulfur subunittarget
DB08690Ubiquinone Q2Cytochrome c1target
DB08690Ubiquinone Q2Reaction center protein L chaintarget
DB08690Ubiquinone Q2Reaction center protein M chaintarget
DB08690Ubiquinone Q2Reaction center protein H chaintarget
DB09270UbidecarenoneNADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrialtarget
DB09270UbidecarenoneSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialtarget
DB09270UbidecarenoneLow-density lipoprotein receptorcarrier
DB09270UbidecarenoneVery low-density lipoprotein receptorcarrier
DB09270UbidecarenoneP-glycoprotein 1transporter
DB09270Ubidecarenone3-hydroxy-3-methylglutaryl-coenzyme A reductaseenzyme
DB11365SennosidesReverse transcriptase/RNaseHtarget
DB11365SennosidesAquaporin-3target
DB11994DiacereinOxysterols receptor LXR-alphatarget
DB11994DiacereinOxysterols receptor LXR-betatarget
DB11994DiacereinArylamine N-acetyltransferasetarget
DB11994DiacereinArachidonate 5-lipoxygenasetarget
DB11994DiacereinCytochrome P450 1A2target
DB11994DiacereinCytochrome P450 3A Subfamilytarget
DB11994DiacereinCytochrome P450 2E1target
DB11994DiacereinCytochrome P450 2C9target
DB11994DiacereinCytochrome P450 2D6target
DB12442AlvespimycinHeat shock protein HSP 90-alphatarget
DB13174RheinOxysterols receptor LXR-alphatarget
DB13174RheinOxysterols receptor LXR-betatarget
DB13174RheinArylamine N-acetyltransferasetarget
DB13174RheinArachidonate 5-lipoxygenasetarget
DB13174RheinCytochrome P450 1A2enzyme
DB13174RheinCytochrome P450 3A Subfamilyenzyme
DB13174RheinCytochrome P450 2E1enzyme
DB13174RheinCytochrome P450 2C9enzyme
DB13174RheinCytochrome P450 2D6enzyme
DB07715EmodinCasein kinase II subunit alphatarget
DB07715EmodinPutative ketoacyl reductasetarget
DB07715Emodin3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZtarget
DB07715EmodinAryl hydrocarbon receptortarget
DB11948LapachoneRetinol-binding protein 3target
DB02521FlaviolinPutative cytochrome P450target
DB02521FlaviolinPrenyltransferasetarget
DB08660QuinalizarinCasein kinase II subunit alphatarget
DB08689Ubiquinone Q1Photosynthetic reaction center cytochrome c subunittarget
DB08689Ubiquinone Q1Reaction center protein H chaintarget
DB08689Ubiquinone Q1Reaction center protein L chaintarget
DB08689Ubiquinone Q1Reaction center protein M chaintarget
DB08689Ubiquinone Q1Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialtarget
DB08689Ubiquinone Q1Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialtarget
DB08689Ubiquinone Q1Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrialtarget
DB08689Ubiquinone Q1Succinate dehydrogenase cytochrome b560 subunit, mitochondrialtarget
DB08689Ubiquinone Q1Thiol:disulfide interchange protein DsbAtarget
DB08689Ubiquinone Q1Disulfide bond formation protein Btarget
DB08689Ubiquinone Q1NrfC proteintarget
DB08689Ubiquinone Q1Thiosulfate reductasetarget
DB08689Ubiquinone Q1Hypothetical membrane spanning proteintarget