Alloin

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

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Name
Alloin
Accession Number
DB15477
Type
Small Molecule
Groups
Approved, Experimental
Description
Not Available
Structure
Thumb
Synonyms
  • Aloin
  • Aloin, Cape
  • Aloin, curaco
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Aid-lax TabAlloin (12 mg) + Frangula purshiana bark (30 mg) + Phenolphthalein (100 mg) + Sodium taurocholate (60 mg)TabletOralNobel Pharm Enr.1989-12-311997-07-31Canada
AlsilineAlloin (12 mg) + Frangula purshiana bark (30 mg) + Phenolphthalein (100 mg) + Sodium taurocholate (60 mg)TabletOralAlsi Cie Ltee1978-12-311997-08-08Canada
Bicholate Lilas TabAlloin (12 mg) + Frangula purshiana bark (30 mg) + Phenolphthalein (100 mg) + Sodium taurocholate (60 mg)TabletOralSabex Inc1991-12-311997-10-10Canada
Bilex TabAlloin (12 mg) + Frangula purshiana bark (30 mg) + Phenolphthalein (100 mg) + Sodium taurocholate (60 mg)TabletOralBiodo Enrg1978-12-311997-10-10Canada
Carters Little Pills TabAlloin (8 mg) + Phenolphthalein (16 mg)TabletOralCarter Products, Division Of Carter Wallace Ns Inc.1978-12-311997-08-14Canada
Lax-BO TabAlloin (12 mg) + Frangula purshiana bark (30 mg) + Phenolphthalein (100 mg) + Sodium taurocholate (60 mg)TabletOralCardinaux Medicinat Inc.1992-12-311996-09-09Canada
Laxatif TabAlloin (12 mg) + Frangula purshiana bark (30 mg) + Phenolphthalein (100 mg) + Sodium taurocholate (60 mg)TabletOralVitalab1991-12-311997-12-18Canada
Laxative TabAlloin (12 mg) + Frangula purshiana bark (30 mg) + Phenolphthalein (100 mg) + Sodium taurocholate (60 mg)TabletOralLaboratoire Lalco Inc.1978-12-311997-10-10Canada
Laxavite TabAlloin (12 mg) + Frangula purshiana bark (30 mg) + Phenolphthalein (100 mg) + Sodium taurocholate (60 mg)TabletOralNeosol Enrg1978-12-311997-07-29Canada
Robol TabAlloin (16.2 mg) + Belladonna (5.4 mg) + Ipecac (4.32 mg) + Phenolphthalein (64.8 mg)TabletOralLabs Anglo French1979-12-311997-08-05Canada
Categories
UNII
W41H6S09F4
CAS number
8015-61-0
Weight
Average: 418.398
Monoisotopic: 418.126382288
Chemical Formula
C21H22O9
InChI Key
AFHJQYHRLPMKHU-CGISPIQUSA-N
InChI
InChI=1S/C21H22O9/c22-6-8-4-10-14(21-20(29)19(28)17(26)13(7-23)30-21)9-2-1-3-11(24)15(9)18(27)16(10)12(25)5-8/h1-5,13-14,17,19-26,28-29H,6-7H2/t13-,14?,17-,19+,20-,21+/m1/s1
IUPAC Name
1,8-dihydroxy-3-(hydroxymethyl)-10-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-9,10-dihydroanthracen-9-one
SMILES
OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)C1C2=CC=CC(O)=C2C(=O)C2=C1C=C(CO)C=C2O

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AcetazolamideThe risk or severity of adverse effects can be increased when Acetazolamide is combined with Alloin.
AclidiniumThe therapeutic efficacy of Alloin can be decreased when used in combination with Aclidinium.
AgmatineThe therapeutic efficacy of Alloin can be decreased when used in combination with Agmatine.
AlcuroniumThe therapeutic efficacy of Alloin can be decreased when used in combination with Alcuronium.
AlfentanilThe therapeutic efficacy of Alloin can be decreased when used in combination with Alfentanil.
AlphacetylmethadolThe therapeutic efficacy of Alloin can be decreased when used in combination with Alphacetylmethadol.
AlphaprodineThe therapeutic efficacy of Alloin can be decreased when used in combination with Alphaprodine.
AmantadineThe therapeutic efficacy of Alloin can be decreased when used in combination with Amantadine.
AmilorideThe risk or severity of adverse effects can be increased when Amiloride is combined with Alloin.
AmiodaroneThe therapeutic efficacy of Alloin can be decreased when used in combination with Amiodarone.
Additional Data Available
  • Extended Description
    Extended Description

    Extended description of the mechanism of action and particular properties of each drug interaction.

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  • Severity
    Severity

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  • Evidence Level
    Evidence Level

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  • Action
    Action

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Food Interactions
Not Available

References

General References
Not Available
External Links
ChemSpider
8042387
BindingDB
50269016
ChEBI
73222
ChEMBL
CHEMBL497001
Wikipedia
Aloin

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
TabletOral
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility2.63 mg/mLALOGPS
logP-0.49ALOGPS
logP0.41ChemAxon
logS-2.2ALOGPS
pKa (Strongest Acidic)8.31ChemAxon
pKa (Strongest Basic)-2.9ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count9ChemAxon
Hydrogen Donor Count7ChemAxon
Polar Surface Area167.91 Å2ChemAxon
Rotatable Bond Count3ChemAxon
Refractivity103.79 m3·mol-1ChemAxon
Polarizability40.97 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveNoChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Drug created on August 30, 2019 09:38 / Updated on November 02, 2019 03:33