DB00175 | Pravastatin | An HMG-CoA reductase inhibitor used to lower lipid levels and to reduce the risk of cardiovascular events, including myocardial infarction and stroke. |
DB00227 | Lovastatin | An HMG-CoA reductase inhibitor used to lower LDL cholesterol and reduce the risk of cardiovascular disease and associated conditions, including myocardial infarction and stroke. |
DB00439 | Cerivastatin | A statin (or HMG CoA reductase inhibitor) used with dietary changes to decrease lipid levels and reduce the risk of cardiovascular events. |
DB00636 | Clofibrate | A fibric acid derivative used to treat hypertriglyceridemia and high cholesterol. |
DB00641 | Simvastatin | An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular events including myocardial infarction and stroke. |
DB00930 | Colesevelam | A bile acid sequestrant used to lower LDL-C in adults with hyperlipidemia and pediatric patients with heterozygous familial hypercholesterolemia, and to improve glycemic control in type 2 diabetes. |
DB00973 | Ezetimibe | A cholesterol absorption inhibitor used to lower total cholesterol, LDL-C, Apo B, and non-HDL-C in primary hyperlipidemia and familial cholesterolemia. |
DB01076 | Atorvastatin | An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke. |
DB01098 | Rosuvastatin | An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke. |
DB01432 | Cholestyramine | A bile acid sequestrant used as an adjunct in the reduction of elevated serum cholesterol in patients with primary hypercholesterolemia, and for the relief of pruritus associated with partial biliary obstruction. |
DB01599 | Probucol | Used to lower LDL and HDL cholesterol. |
DB05528 | Mipomersen | An oligonucleotide drug used for the treatment of homozygous familial hypercholesterolemia. |
DB06281 | Torcetrapib | Investigated for use/treatment in peripheral vascular disease and hyperlipidemia. |
DB06630 | Anacetrapib | Investigated for use/treatment in hyperlipidemia. |
DB06693 | Mevastatin | Not used therapeutically due to its many side effects. |
DB08860 | Pitavastatin | An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke. |
DB08983 | Etofibrate | Etofibrate is a fibrate produced by the combination of clofibrate ester linked to niacin. These components separate in the body slowly allowing for pharmacokinetics similar to controlled-release formulations. |
DB11234 | Poliglusam | Poliglusam, or chitosan, is a linear polysaccharide consisting of D-glucosamine and N-acetyl-D-glucosamine. Naturally-occuring poliglusam is found in the cell walls of fungi, soil and sediments where it is produced from... |
DB11655 | Evacetrapib | Evacetrapib has been used in trials studying the basic science and treatment of Dyslipidemia, Hyperlipidemia, Hypercholesterolemia, Hepatic Insufficiency, and Cardiovascular Disease. |
DB12181 | Dalcetrapib | Dalcetrapib is under investigation for the treatment of Acute Coronary Syndrome. |
DB13873 | Fenofibric acid | A fibrate used to treat severe hypertriglyceridemia, primary hypercholesterolemia, or mixed dyslipidemia. |
DB04377 | Meglutol | An antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conversion of acetate to hydroxymethylglutaryl coenzyme A as... |
DB09303 | Evolocumab | A PCSK9 (proprotein convertase subtilisin kexin type 9) inhibitor antibody used as an adjunct to LDL cholesterol reducing therapies, aiding in the prevention of cardiovascular events and cardiovascular revascularization procedures. |
DB12456 | Bococizumab | Bococizumab has been used in trials studying the treatment and prevention of Dyslipidemia, Hyperlipidemia, Hypercholesterolemia, Cardiovascular Disease, and Heterozygous Familial Hypercholesterolemia. |