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Identification
NameSimvastatin
Accession NumberDB00641  (APRD00104)
TypeSmall Molecule
GroupsApproved
DescriptionSimvastatin is a lipid-lowering agent that is derived synthetically from the fermentation of Aspergillus terreus. It is a potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (hydroxymethylglutaryl COA reductases), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL receptors, it increases breakdown of LDL cholesterol. [PubChem]
Structure
Thumb
Synonyms
2,2-Dimethylbutyric acid, 8-ester with (4R,6R)-6-(2-((1S,2S,6R,8S,8ar)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthyl)ethyl)tetrahydro-4-hydroxy-2H-pyran-2-one
MK-733
Simvastatin
Simvastatina
Simvastatine
Simvastatinum
Synvinolin
Zocor
External Identifiers
  • MK 733
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Act SimvastatinTablet20 mgOralActavis Pharma Company2003-09-26Not applicableCanada
Act SimvastatinTablet40 mgOralActavis Pharma Company2003-09-26Not applicableCanada
Act SimvastatinTablet80 mgOralActavis Pharma Company2003-09-26Not applicableCanada
Act SimvastatinTablet5 mgOralActavis Pharma Company2003-09-26Not applicableCanada
Act SimvastatinTablet10 mgOralActavis Pharma Company2003-09-26Not applicableCanada
Auro-simvastatinTablet80 mgOralAuro Pharma Inc2013-07-08Not applicableCanada
Auro-simvastatinTablet40 mgOralAuro Pharma Inc2013-07-08Not applicableCanada
Auro-simvastatinTablet10 mgOralAuro Pharma Inc2013-07-08Not applicableCanada
Auro-simvastatinTablet20 mgOralAuro Pharma Inc2013-07-08Not applicableCanada
Auro-simvastatinTablet5 mgOralAuro Pharma Inc2013-07-08Not applicableCanada
Ava-simvastatinTablet5 mgOralAvanstra Inc2011-10-112014-08-21Canada
Ava-simvastatinTablet80 mgOralAvanstra Inc2011-10-112014-08-21Canada
Ava-simvastatinTablet10 mgOralAvanstra Inc2011-10-112014-08-21Canada
Ava-simvastatinTablet20 mgOralAvanstra Inc2011-10-112014-08-21Canada
Ava-simvastatinTablet40 mgOralAvanstra Inc2011-10-112014-08-21Canada
Bci SimvastatinTablet10 mgOralBaker Cummins IncNot applicableNot applicableCanada
Bci SimvastatinTablet20 mgOralBaker Cummins IncNot applicableNot applicableCanada
Bci SimvastatinTablet40 mgOralBaker Cummins IncNot applicableNot applicableCanada
Bci SimvastatinTablet5 mgOralBaker Cummins IncNot applicableNot applicableCanada
Bci SimvastatinTablet80 mgOralBaker Cummins IncNot applicableNot applicableCanada
Dom-simvastatinTablet80 mgOralDominion Pharmacal2004-08-11Not applicableCanada
Dom-simvastatinTablet80 mgOralDominion Pharmacal2006-08-02Not applicableCanada
Dom-simvastatinTablet10 mgOralDominion Pharmacal2004-08-11Not applicableCanada
Dom-simvastatinTablet10 mgOralDominion Pharmacal2006-08-02Not applicableCanada
Dom-simvastatinTablet20 mgOralDominion Pharmacal2004-08-11Not applicableCanada
Dom-simvastatinTablet20 mgOralDominion Pharmacal2006-08-02Not applicableCanada
Dom-simvastatinTablet40 mgOralDominion Pharmacal2004-08-11Not applicableCanada
Dom-simvastatinTablet40 mgOralDominion Pharmacal2006-08-02Not applicableCanada
Dom-simvastatinTablet5 mgOralDominion Pharmacal2004-08-11Not applicableCanada
Dom-simvastatinTablet5 mgOralDominion Pharmacal2006-08-02Not applicableCanada
Ipg-simvastatinTablet40 mgOralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Ipg-simvastatinTablet5 mgOralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Ipg-simvastatinTablet80 mgOralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Ipg-simvastatinTablet10 mgOralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Ipg-simvastatinTablet20 mgOralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Jamp-simvastatinTablet40 mgOralJamp Pharma Corporation2012-01-09Not applicableCanada
Jamp-simvastatinTablet20 mgOralJamp Pharma Corporation2010-03-122013-07-08Canada
Jamp-simvastatinTablet5 mgOralJamp Pharma Corporation2012-01-09Not applicableCanada
Jamp-simvastatinTablet80 mgOralJamp Pharma Corporation2012-01-09Not applicableCanada
Jamp-simvastatinTablet40 mgOralJamp Pharma Corporation2010-03-122013-07-08Canada
Jamp-simvastatinTablet10 mgOralJamp Pharma Corporation2012-01-09Not applicableCanada
Jamp-simvastatinTablet5 mgOralJamp Pharma Corporation2010-03-232013-07-08Canada
Jamp-simvastatinTablet80 mgOralJamp Pharma Corporation2010-03-122013-07-08Canada
Jamp-simvastatinTablet20 mgOralJamp Pharma Corporation2012-01-09Not applicableCanada
Jamp-simvastatinTablet10 mgOralJamp Pharma Corporation2010-03-122013-07-08Canada
Mar-simvastatinTablet80 mgOralMarcan Pharmaceuticals Inc2012-12-20Not applicableCanada
Mar-simvastatinTablet10 mgOralMarcan Pharmaceuticals Inc2012-12-20Not applicableCanada
Mar-simvastatinTablet20 mgOralMarcan Pharmaceuticals Inc2012-12-20Not applicableCanada
Mar-simvastatinTablet40 mgOralMarcan Pharmaceuticals Inc2012-12-20Not applicableCanada
Mar-simvastatinTablet5 mgOralMarcan Pharmaceuticals Inc2012-12-20Not applicableCanada
Mint-simvastatinTablet20 mgOralMint Pharmaceuticals Inc2011-09-07Not applicableCanada
Mint-simvastatinTablet40 mgOralMint Pharmaceuticals Inc2011-09-07Not applicableCanada
Mint-simvastatinTablet80 mgOralMint Pharmaceuticals Inc2011-09-07Not applicableCanada
Mint-simvastatinTablet5 mgOralMint Pharmaceuticals Inc2011-09-07Not applicableCanada
Mint-simvastatinTablet10 mgOralMint Pharmaceuticals Inc2011-09-07Not applicableCanada
Mylan-simvastatinTablet40 mgOralMylan Pharmaceuticals Ulc2003-01-15Not applicableCanada
Mylan-simvastatinTablet80 mgOralMylan Pharmaceuticals Ulc2003-01-15Not applicableCanada
Mylan-simvastatinTablet5 mgOralMylan Pharmaceuticals Ulc2003-01-15Not applicableCanada
Mylan-simvastatinTablet20 mgOralMylan Pharmaceuticals Ulc2003-01-15Not applicableCanada
Mylan-simvastatinTablet10 mgOralMylan Pharmaceuticals Ulc2003-01-15Not applicableCanada
Ntp-simvastatinTablet5 mgOralNt Pharma Canada LtdNot applicableNot applicableCanada
Ntp-simvastatinTablet80 mgOralNt Pharma Canada LtdNot applicableNot applicableCanada
Ntp-simvastatinTablet10 mgOralNt Pharma Canada LtdNot applicableNot applicableCanada
Ntp-simvastatinTablet20 mgOralNt Pharma Canada LtdNot applicableNot applicableCanada
Ntp-simvastatinTablet40 mgOralNt Pharma Canada LtdNot applicableNot applicableCanada
Nu-simvastatin TabletsTablet10 mgOralNu Pharm Inc2004-06-212012-09-04Canada
Nu-simvastatin TabletsTablet20 mgOralNu Pharm Inc2004-06-212012-09-04Canada
Nu-simvastatin TabletsTablet40 mgOralNu Pharm Inc2004-06-212012-09-04Canada
Nu-simvastatin TabletsTablet80 mgOralNu Pharm Inc2004-06-212012-09-04Canada
Nu-simvastatin TabletsTablet5 mgOralNu Pharm Inc2004-06-212012-09-04Canada
PHL-simvastatinTablet20 mgOralPharmel Inc2004-08-11Not applicableCanada
PHL-simvastatinTablet20 mgOralPharmel Inc2006-07-21Not applicableCanada
PHL-simvastatinTablet40 mgOralPharmel Inc2004-08-11Not applicableCanada
PHL-simvastatinTablet40 mgOralPharmel Inc2006-07-21Not applicableCanada
PHL-simvastatinTablet80 mgOralPharmel Inc2004-08-11Not applicableCanada
PHL-simvastatinTablet80 mgOralPharmel Inc2006-07-21Not applicableCanada
PHL-simvastatinTablet5 mgOralPharmel Inc2004-08-11Not applicableCanada
PHL-simvastatinTablet5 mgOralPharmel Inc2006-07-21Not applicableCanada
PHL-simvastatinTablet10 mgOralPharmel Inc2004-08-11Not applicableCanada
PHL-simvastatinTablet10 mgOralPharmel Inc2006-07-21Not applicableCanada
PMS-simvastatinTablet40 mgOralPharmascience Inc2004-05-07Not applicableCanada
PMS-simvastatinTablet40 mgOralPharmascience Inc2005-11-03Not applicableCanada
PMS-simvastatinTablet5 mgOralPharmascience Inc2004-05-07Not applicableCanada
PMS-simvastatinTablet5 mgOralPharmascience Inc2005-11-03Not applicableCanada
PMS-simvastatinTablet80 mgOralPharmascience Inc2004-05-07Not applicableCanada
PMS-simvastatinTablet80 mgOralPharmascience Inc2005-11-03Not applicableCanada
PMS-simvastatinTablet10 mgOralPharmascience Inc2004-05-07Not applicableCanada
PMS-simvastatinTablet10 mgOralPharmascience Inc2005-11-03Not applicableCanada
PMS-simvastatinTablet20 mgOralPharmascience Inc2004-05-07Not applicableCanada
PMS-simvastatinTablet20 mgOralPharmascience Inc2005-11-03Not applicableCanada
Q-simvastatinTablet10 mgOralQd Pharmaceuticals Ulc2012-02-032015-08-21Canada
Q-simvastatinTablet20 mgOralQd Pharmaceuticals Ulc2012-02-032015-08-21Canada
Q-simvastatinTablet5 mgOralQd Pharmaceuticals UlcNot applicableNot applicableCanada
Q-simvastatinTablet40 mgOralQd Pharmaceuticals Ulc2012-02-032015-08-21Canada
Q-simvastatinTablet80 mgOralQd Pharmaceuticals UlcNot applicableNot applicableCanada
Ran-simvastatinTablet20 mgOralRanbaxy Pharmaceuticals Canada Inc.2009-07-20Not applicableCanada
Ran-simvastatinTablet40 mgOralRanbaxy Pharmaceuticals Canada Inc.2009-07-20Not applicableCanada
Ran-simvastatinTablet80 mgOralRanbaxy Pharmaceuticals Canada Inc.2009-07-20Not applicableCanada
Ran-simvastatinTablet5 mgOralRanbaxy Pharmaceuticals Canada Inc.2009-07-20Not applicableCanada
Ran-simvastatinTablet10 mgOralRanbaxy Pharmaceuticals Canada Inc.2009-07-20Not applicableCanada
Ratio-simvastatinTablet20 mgOralRatiopharm Inc Division Of Teva Canada Limited2003-10-272014-09-19Canada
Ratio-simvastatinTablet40 mgOralRatiopharm Inc Division Of Teva Canada Limited2003-10-272014-09-19Canada
Ratio-simvastatinTablet5 mgOralRatiopharm Inc Division Of Teva Canada Limited2003-10-272014-09-19Canada
Ratio-simvastatinTablet80 mgOralRatiopharm Inc Division Of Teva Canada Limited2003-10-272014-09-19Canada
Ratio-simvastatinTablet10 mgOralRatiopharm Inc Division Of Teva Canada Limited2003-10-272014-09-19Canada
Riva-simvastatinTablet80 mgOralLaboratoire Riva Inc2003-03-10Not applicableCanada
Riva-simvastatinTablet10 mgOralLaboratoire Riva Inc2003-03-10Not applicableCanada
Riva-simvastatinTablet20 mgOralLaboratoire Riva Inc2003-03-10Not applicableCanada
Riva-simvastatinTablet40 mgOralLaboratoire Riva Inc2003-03-10Not applicableCanada
Riva-simvastatinTablet5 mgOralLaboratoire Riva Inc2003-03-10Not applicableCanada
Sandoz SimvastatinTablet40 mgOralSandoz Canada Incorporated2003-10-29Not applicableCanada
Sandoz SimvastatinTablet5 mgOralSandoz Canada Incorporated2003-10-29Not applicableCanada
Sandoz SimvastatinTablet80 mgOralSandoz Canada Incorporated2003-10-29Not applicableCanada
Sandoz SimvastatinTablet10 mgOralSandoz Canada Incorporated2003-10-29Not applicableCanada
Sandoz SimvastatinTablet20 mgOralSandoz Canada Incorporated2004-06-23Not applicableCanada
Septa-simvastatinTablet10 mgOralSepta Pharmaceuticals IncNot applicableNot applicableCanada
Septa-simvastatinTablet20 mgOralSepta Pharmaceuticals IncNot applicableNot applicableCanada
Septa-simvastatinTablet40 mgOralSepta Pharmaceuticals IncNot applicableNot applicableCanada
Septa-simvastatinTablet5 mgOralSepta Pharmaceuticals IncNot applicableNot applicableCanada
Septa-simvastatinTablet80 mgOralSepta Pharmaceuticals IncNot applicableNot applicableCanada
SimvastatinTablet20 mgOralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
SimvastatinTablet10 mgOralBentec Pharma Inc2013-03-012015-12-15Canada
SimvastatinTablet80 mgOralFrosst A Division Of Merck Canada IncNot applicableNot applicableCanada
SimvastatinTablet20 mgOralSivem Pharmaceuticals Ulc2012-06-12Not applicableCanada
SimvastatinTablet40 mgOralSanis Health Inc2009-10-22Not applicableCanada
SimvastatinTablet10 mgOralMeliapharm Inc2010-06-112014-06-25Canada
SimvastatinTablet40 mgOralBentec Pharma IncNot applicableNot applicableCanada
SimvastatinTablet10 mgOralFrosst A Division Of Merck Canada IncNot applicableNot applicableCanada
SimvastatinTablet40 mgOralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
SimvastatinTablet5 mgOralSanis Health Inc2009-10-22Not applicableCanada
SimvastatinTablet40 mgOralSivem Pharmaceuticals Ulc2012-06-11Not applicableCanada
SimvastatinTablet80 mgOralBentec Pharma IncNot applicableNot applicableCanada
SimvastatinTablet80 mgOralSanis Health Inc2009-10-22Not applicableCanada
SimvastatinTablet20 mgOralMeliapharm Inc2010-06-112014-06-25Canada
SimvastatinTablet5 mgOralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
SimvastatinTablet20 mgOralFrosst A Division Of Merck Canada IncNot applicableNot applicableCanada
SimvastatinTablet10 mgOralSanis Health Inc2009-10-22Not applicableCanada
SimvastatinTablet80 mgOralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
SimvastatinTablet5 mgOralBentec Pharma IncNot applicableNot applicableCanada
SimvastatinTablet80 mgOralSivem Pharmaceuticals Ulc2012-06-11Not applicableCanada
SimvastatinTablet5 mgOralSivem Pharmaceuticals Ulc2012-06-11Not applicableCanada
SimvastatinTablet40 mgOralMeliapharm Inc2010-06-112014-06-25Canada
SimvastatinTablet10 mgOralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
SimvastatinTablet40 mgOralFrosst A Division Of Merck Canada IncNot applicableNot applicableCanada
SimvastatinTablet20 mgOralSanis Health Inc2009-10-22Not applicableCanada
SimvastatinTablet5 mgOralMeliapharm Inc2010-06-112014-06-25Canada
SimvastatinTablet20 mgOralBentec Pharma IncNot applicableNot applicableCanada
SimvastatinTablet5 mgOralFrosst A Division Of Merck Canada IncNot applicableNot applicableCanada
SimvastatinTablet10 mgOralSivem Pharmaceuticals Ulc2012-06-11Not applicableCanada
SimvastatinTablet80 mgOralMeliapharm Inc2010-06-112014-06-25Canada
Simvastatin TabletsTablet5 mgOralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Simvastatin TabletsTablet80 mgOralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Simvastatin TabletsTablet10 mgOralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Simvastatin TabletsTablet20 mgOralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Simvastatin TabletsTablet40 mgOralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Simvastatin Tablets 10mgTablet10 mgOralPrempharm Inc2003-09-032005-08-05Canada
Simvastatin Tablets 20mgTablet20 mgOralPrempharm Inc2003-09-032005-08-05Canada
Simvastatin Tablets 40mgTablet40 mgOralPrempharm Inc2003-09-032005-08-05Canada
Simvastatin Tablets 5mgTablet5 mgOralPrempharm Inc2003-09-032005-08-05Canada
Simvastatin Tablets 80mgTablet80 mgOralPrempharm Inc2003-09-032005-08-05Canada
Simvastatin-10Tablet10 mgOralPro Doc Limitee2003-04-10Not applicableCanada
Simvastatin-20Tablet20 mgOralPro Doc Limitee2003-04-10Not applicableCanada
Simvastatin-40Tablet40 mgOralPro Doc Limitee2003-04-10Not applicableCanada
Simvastatin-80Tablet80 mgOralPro Doc Limitee2009-06-15Not applicableCanada
Simvastatin-odanTablet20 mgOralOdan Laboratories Ltd2012-02-142014-11-12Canada
Simvastatin-odanTablet40 mgOralOdan Laboratories Ltd2012-02-142014-11-12Canada
Simvastatin-odanTablet5 mgOralOdan Laboratories Ltd2012-02-142014-11-12Canada
Simvastatin-odanTablet80 mgOralOdan Laboratories Ltd2012-02-142014-11-17Canada
Simvastatin-odanTablet10 mgOralOdan Laboratories Ltd2012-02-142014-11-12Canada
Taro-simvastatinTablet40 mgOralTaro Pharmaceuticals Inc2005-08-102014-04-01Canada
Taro-simvastatinTablet10 mgOralTaro Pharmaceuticals Inc2005-08-102014-04-01Canada
Taro-simvastatinTablet20 mgOralTaro Pharmaceuticals Inc2005-08-102014-04-01Canada
Teva-simvastatinTablet80 mgOralTeva Canada Limited2004-03-22Not applicableCanada
Teva-simvastatinTablet10 mgOralTeva Canada Limited2004-03-22Not applicableCanada
Teva-simvastatinTablet20 mgOralTeva Canada Limited2004-03-22Not applicableCanada
Teva-simvastatinTablet40 mgOralTeva Canada Limited2004-03-22Not applicableCanada
Teva-simvastatinTablet5 mgOralTeva Canada Limited2004-03-22Not applicableCanada
ZocorTablet20 mgOralMerck Canada Inc1994-12-31Not applicableCanada
ZocorTablet, film coated80 mg/1OralMerck Sharp & Dohme Corp.1991-12-23Not applicableUs
ZocorTablet, film coated40 mg/1OralMerck Sharp & Dohme Corp.1991-12-23Not applicableUs
ZocorTablet80 mgOralMerck Canada Inc1999-07-212014-05-06Canada
ZocorTablet5 mgOralMerck Canada Inc1991-12-312016-06-08Canada
ZocorTablet40 mgOralMerck Canada Inc1996-08-14Not applicableCanada
ZocorTablet, film coated5 mg/1OralMerck Sharp & Dohme Corp.1991-12-23Not applicableUs
ZocorTablet, film coated20 mg/1OralLake Erie Medical Surgical & Supply DBA Quality Care Products LLC2011-08-08Not applicableUs
ZocorTablet, film coated10 mg/1OralMerck Sharp & Dohme Corp.1991-12-23Not applicableUs
ZocorTablet10 mgOralMerck Canada Inc1990-12-31Not applicableCanada
ZocorTablet, film coated20 mg/1OralMerck Sharp & Dohme Corp.1991-12-23Not applicableUs
Zym-simvastatinTablet40 mgOralZymcan Pharmaceuticals Inc2009-02-262014-06-16Canada
Zym-simvastatinTablet80 mgOralZymcan Pharmaceuticals Inc2009-02-262014-06-16Canada
Zym-simvastatinTablet5 mgOralZymcan Pharmaceuticals Inc2009-02-262014-06-16Canada
Zym-simvastatinTablet10 mgOralZymcan Pharmaceuticals Inc2009-02-262014-06-16Canada
Zym-simvastatinTablet20 mgOralZymcan Pharmaceuticals Inc2009-02-262014-06-16Canada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-simvastatinTablet20 mgOralApotex Inc2002-12-20Not applicableCanada
Apo-simvastatinTablet40 mgOralApotex Inc2002-12-20Not applicableCanada
Apo-simvastatinTablet5 mgOralApotex Inc2002-12-20Not applicableCanada
Apo-simvastatinTablet80 mgOralApotex Inc2002-12-20Not applicableCanada
Apo-simvastatinTablet10 mgOralApotex Inc2002-12-20Not applicableCanada
SimvastatinTablet5 mg/1OralPhysicians Total Care, Inc.2009-09-24Not applicableUs
SimvastatinTablet, film coated40 mg/1OralCardinal Health2011-10-03Not applicableUs
SimvastatinTablet, film coated40 mg/1OralDIRECT RX2014-01-01Not applicableUs
SimvastatinTablet, film coated20 mg/1OralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2008-03-31Not applicableUs
SimvastatinTablet, film coated20 mg/1OralCadila Healthcare Limited2006-12-20Not applicableUs
SimvastatinTablet, film coated10 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2006-12-20Not applicableUs
SimvastatinTablet, film coated5 mg/1OralCarilion Materials Management2006-06-27Not applicableUs
SimvastatinTablet, film coated80 mg/1OralLegacy Pharmaceutical Packaging2006-12-20Not applicableUs
SimvastatinTablet5 mg/1OralCobalt Laboratories Inc.2006-12-20Not applicableUs
SimvastatinTablet5 mg/1OralRebel Distributors Corp2009-09-24Not applicableUs
SimvastatinTablet, film coated5 mg/1OralCamber Pharmaceuticals, Inc.2014-12-09Not applicableUs
SimvastatinTablet, film coated10 mg/1OralPd Rx Pharmaceuticals, Inc.2006-12-20Not applicableUs
SimvastatinTablet, film coated10 mg/1OralRebel Distributors Corp2008-02-26Not applicableUs
SimvastatinTablet, film coated80 mg/1OralREMEDYREPACK INC.2013-02-19Not applicableUs
SimvastatinTablet, film coated20 mg/1OralSafecor Health, LLC2014-09-30Not applicableUs
SimvastatinTablet, film coated80 mg/1OralPreferred Pharmaceuticals, Inc.2014-10-21Not applicableUs
SimvastatinTablet, film coated40 mg/1OralUnit Dose Services2008-02-26Not applicableUs
SimvastatinTablet, film coated5 mg/1OralA S Medication Solutions2006-12-20Not applicableUs
SimvastatinTablet, film coated10 mg/1OralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
SimvastatinTablet, film coated40 mg/1OralPd Rx Pharmaceuticals, Inc.2008-02-26Not applicableUs
SimvastatinTablet, film coated40 mg/1OralMylan Institutional Inc.2006-07-10Not applicableUs
SimvastatinTablet, film coated20 mg/1OralBiocon Pharma Inc,2015-12-17Not applicableUs
SimvastatinTablet, film coated40 mg/1OralInternational Labs, Inc.2013-09-19Not applicableUs
SimvastatinTablet, film coated40 mg/1OralCardinal Health2006-12-20Not applicableUs
SimvastatinTablet, film coated40 mg/1OralClinical Solutions Wholesale2008-02-26Not applicableUs
SimvastatinTablet, film coated80 mg/1OralRanbaxy Pharmaceuticals Inc.2006-12-20Not applicableUs
SimvastatinTablet, film coated5 mg/1OralBiocon Limited2015-12-17Not applicableUs
SimvastatinTablet, film coated5 mg/1OralKAISER FOUNDATION HOSPITALS2013-02-01Not applicableUs
SimvastatinTablet, film coated20 mg/1OralMed Vantx, Inc.2006-06-27Not applicableUs
SimvastatinTablet, film coated5 mg/1OralZydus Pharmaceuticals (USA) Inc.2006-12-20Not applicableUs
SimvastatinTablet, film coated80 mg/1OralBlenheim Pharmacal, Inc.2015-03-26Not applicableUs
SimvastatinTablet, film coated40 mg/1OralNorth Star Rx Llc2006-12-20Not applicableUs
SimvastatinTablet, film coated20 mg/1OralMc Kesson Contract Packaging2011-08-18Not applicableUs
SimvastatinTablet, film coated40 mg/1OralBlu Pharmaceuticals, LLC2008-02-01Not applicableUs
SimvastatinTablet, film coated40 mg/1OralLUPIN LIMITED2015-12-02Not applicableUs
SimvastatinTablet, film coated20 mg/1OralRx Change Co.2008-02-26Not applicableUs
SimvastatinTablet, film coated5 mg/1OralTeva Pharmaceuticals USA Inc2006-06-27Not applicableUs
SimvastatinTablet, film coated80 mg/1OralAphena Pharma Solutions Tennessee, Inc.2011-10-17Not applicableUs
SimvastatinTablet, film coated10 mg/1OralREMEDYREPACK INC.2015-03-17Not applicableUs
SimvastatinTablet, film coated20 mg/1OralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2011-11-22Not applicableUs
SimvastatinTablet, film coated10 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2007-06-12Not applicableUs
SimvastatinTablet, film coated20 mg/1OralMajor Pharmaceuticals2006-12-20Not applicableUs
SimvastatinTablet, film coated20 mg/1OralLupin Pharmaceuticals, Inc.2007-06-14Not applicableUs
SimvastatinTablet, film coated40 mg/1OralPreferred Pharmaceuticals, Inc.2012-03-29Not applicableUs
SimvastatinTablet80 mg/1OralCobalt Laboratories Inc.2006-12-20Not applicableUs
SimvastatinTablet80 mg/1OralRebel Distributors Corp2007-05-23Not applicableUs
SimvastatinTablet, film coated10 mg/1OralLucid Pharma Llc2006-12-20Not applicableUs
SimvastatinTablet, film coated80 mg/1OralCamber Pharmaceuticals, Inc.2014-12-09Not applicableUs
SimvastatinTablet, film coated10 mg/1OralUnit Dose Services2008-02-26Not applicableUs
SimvastatinTablet20 mg/1OralMicro Labs Limited2013-06-13Not applicableUs
SimvastatinTablet, film coated20 mg/1OralCardinal Health2006-12-20Not applicableUs
SimvastatinTablet20 mg/1OralREMEDYREPACK INC.2011-07-15Not applicableUs
SimvastatinTablet, film coated80 mg/1OralKAISER FOUNDATION HOSPITALS2016-09-28Not applicableUs
SimvastatinTablet, film coated40 mg/1OralIngenus Pharmaceuticals, LLC2012-01-04Not applicableUs
SimvastatinTablet, film coated10 mg/1OralA S Medication Solutions2008-02-26Not applicableUs
SimvastatinTablet, film coated40 mg/1OralState of Florida DOH Central Pharmacy2014-01-01Not applicableUs
SimvastatinTablet, film coated40 mg/1OralDr. Reddy's Laboratories Limited2006-12-20Not applicableUs
SimvastatinTablet, film coated10 mg/1OralPd Rx Pharmaceuticals, Inc.2006-06-27Not applicableUs
SimvastatinTablet, film coated5 mg/1OralRanbaxy Pharmaceuticals Inc.2006-12-20Not applicableUs
SimvastatinTablet, film coated20 mg/1OralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2012-11-22Not applicableUs
SimvastatinTablet, film coated10 mg/1OralAurobindo Pharma Limited2006-12-20Not applicableUs
SimvastatinTablet, film coated80 mg/1OralBiocon Limited2015-12-17Not applicableUs
SimvastatinTablet, film coated5 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2007-08-16Not applicableUs
SimvastatinTablet, film coated5 mg/1OralContract Pharmacy Services Pa2010-08-25Not applicableUs
SimvastatinTablet, film coated80 mg/1OralZydus Pharmaceuticals (USA) Inc.2006-12-20Not applicableUs
SimvastatinTablet, film coated20 mg/1OralAurolife Pharma LLC2009-11-09Not applicableUs
SimvastatinTablet, film coated40 mg/1OralAccord Healthcare, Inc.2008-02-26Not applicableUs
SimvastatinTablet, film coated5 mg/1OralH.J. Harkins Company, Inc.2007-08-16Not applicableUs
SimvastatinTablet, film coated20 mg/1OralBlu Pharmceuticals Llc2011-10-17Not applicableUs
SimvastatinTablet, film coated40 mg/1OralLUPIN LIMITED2015-11-23Not applicableUs
SimvastatinTablet, film coated20 mg/1OralLake Erie Medical DBA Quality Care Products LLC2008-02-26Not applicableUs
SimvastatinTablet, film coated80 mg/1OralTeva Pharmaceuticals USA Inc2006-12-20Not applicableUs
SimvastatinTablet, film coated10 mg/1OralAphena Pharma Solutions Tennessee, Llc2006-12-20Not applicableUs
SimvastatinTablet, film coated40 mg/1OralAmerican Health Packaging2011-05-022018-02-28Us
SimvastatinTablet, film coated40 mg/1OralAv Pak2014-12-02Not applicableUs
SimvastatinTablet, film coated40 mg/1OralA S Medication Solutions2008-02-26Not applicableUs
SimvastatinTablet, film coated40 mg/1OralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
SimvastatinTablet, film coated20 mg/1OralUnit Dose Services2008-02-26Not applicableUs
SimvastatinTablet20 mg/1OralPhysicians Total Care, Inc.2008-07-21Not applicableUs
SimvastatinTablet, film coated10 mg/1OralCardinal Health2013-04-04Not applicableUs
SimvastatinTablet, film coated80 mg/1OralSt Marys Medical Park Pharmacy2008-02-26Not applicableUs
SimvastatinTablet, film coated80 mg/1Oralbryant ranch prepack2008-02-26Not applicableUs
SimvastatinTablet, film coated80 mg/1OralUnit Dose Services2008-02-26Not applicableUs
SimvastatinTablet, film coated20 mg/1OralA S Medication Solutions2008-02-26Not applicableUs
SimvastatinTablet, film coated10 mg/1OralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
SimvastatinTablet, film coated10 mg/1OralPd Rx Pharmaceuticals, Inc.2008-02-26Not applicableUs
SimvastatinTablet, film coated5 mg/1OralDr. Reddy's Laboratories Limited2007-08-16Not applicableUs
SimvastatinTablet, film coated10 mg/1OralCardinal Health2011-10-03Not applicableUs
SimvastatinTablet, film coated20 mg/1OralProficient Rx LP2008-02-26Not applicableUs
SimvastatinTablet, film coated40 mg/1OralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2008-03-31Not applicableUs
SimvastatinTablet, film coated40 mg/1OralCadila Healthcare Limited2006-12-20Not applicableUs
SimvastatinTablet, film coated20 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2006-12-20Not applicableUs
SimvastatinTablet, film coated40 mg/1OralLupin Pharmaceuticals, Inc.2015-12-02Not applicableUs
SimvastatinTablet20 mg/1OralLegacy Pharmaceutical Packaging, Llc2007-06-01Not applicableUs
SimvastatinTablet10 mg/1OralCobalt Laboratories Inc.2006-12-20Not applicableUs
SimvastatinTablet10 mg/1OralRebel Distributors Corp2007-02-02Not applicableUs
SimvastatinTablet, film coated10 mg/1OralCamber Pharmaceuticals, Inc.2014-12-09Not applicableUs
SimvastatinTablet, film coated20 mg/1OralREMEDYREPACK INC.2016-03-28Not applicableUs
SimvastatinTablet, film coated80 mg/1OralRebel Distributors Corp2008-02-26Not applicableUs
SimvastatinTablet, film coated40 mg/1OralInternational Laboratories, Inc.2010-11-22Not applicableUs
SimvastatinTablet20 mg/1OralREMEDYREPACK INC.2010-09-212016-10-13Us
SimvastatinTablet, film coated10 mg/1OralPreferred Pharmaceuticals, Inc.2012-02-28Not applicableUs
SimvastatinTablet, film coated20 mg/1OralAphena Pharma Solutions Tennessee, Inc.2011-10-17Not applicableUs
SimvastatinTablet, film coated20 mg/1OralDIRECT RX2014-01-01Not applicableUs
SimvastatinTablet, film coated5 mg/1OralAv Pak2014-12-02Not applicableUs
SimvastatinTablet, film coated20 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2007-06-14Not applicableUs
SimvastatinTablet, film coated10 mg/1OralREMEDYREPACK INC.2013-05-24Not applicableUs
SimvastatinTablet, film coated40 mg/1OralBiocon Pharma Inc,2015-12-17Not applicableUs
SimvastatinTablet, film coated20 mg/1OralInternational Labs, Inc.2013-09-01Not applicableUs
SimvastatinTablet, film coated80 mg/1OralCardinal Health2006-12-20Not applicableUs
SimvastatinTablet, film coated80 mg/1OralClinical Solutions Wholesale2008-02-26Not applicableUs
SimvastatinTablet, film coated40 mg/1Oralbryant ranch prepack2008-02-26Not applicableUs
SimvastatinTablet, film coated10 mg/1OralBiocon Limited2015-12-17Not applicableUs
SimvastatinTablet, film coated10 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2006-12-20Not applicableUs
SimvastatinTablet, film coated20 mg/1OralMed Vantx, Inc.2006-12-20Not applicableUs
SimvastatinTablet, film coated10 mg/1OralZydus Pharmaceuticals (USA) Inc.2006-12-20Not applicableUs
SimvastatinTablet, film coated20 mg/1OralBlenheim Pharmacal, Inc.2015-03-26Not applicableUs
SimvastatinTablet, film coated80 mg/1OralNorth Star Rx Llc2006-12-20Not applicableUs
SimvastatinTablet, film coated40 mg/1OralMc Kesson Contract Packaging2011-10-14Not applicableUs
SimvastatinTablet, film coated80 mg/1OralBlu Pharmaceuticals, LLC2008-02-01Not applicableUs
SimvastatinTablet, film coated80 mg/1OralLUPIN LIMITED2015-12-02Not applicableUs
SimvastatinTablet, film coated40 mg/1OralRx Change Co.2014-11-27Not applicableUs
SimvastatinTablet, film coated10 mg/1OralTeva Pharmaceuticals USA Inc2006-06-27Not applicableUs
SimvastatinTablet, film coated40 mg/1OralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2012-11-22Not applicableUs
SimvastatinTablet, film coated20 mg/1OralAurobindo Pharma Limited2006-12-20Not applicableUs
SimvastatinTablet, film coated40 mg/1OralMajor Pharmaceuticals2006-12-20Not applicableUs
SimvastatinTablet, film coated40 mg/1OralLupin Pharmaceuticals, Inc.2007-06-12Not applicableUs
SimvastatinTablet, film coated20 mg/1OralPreferred Pharmaceuticals, Inc.2012-03-29Not applicableUs
SimvastatinTablet, film coated5 mg/1OralNorth Star Rx Llc2006-12-20Not applicableUs
SimvastatinTablet, film coated5 mg/1OralBlu Pharmaceuticals, LLC2008-02-01Not applicableUs
SimvastatinTablet, film coated20 mg/1OralLucid Pharma Llc2006-12-20Not applicableUs
SimvastatinTablet, film coated20 mg/1OralAidarex Pharmaceuticals LLC2008-02-26Not applicableUs
SimvastatinTablet40 mg/1OralCardinal Health2011-05-02Not applicableUs
SimvastatinTablet40 mg/1OralMicro Labs Limited2013-06-13Not applicableUs
SimvastatinTablet, film coated40 mg/1OralCardinal Health2006-12-20Not applicableUs
SimvastatinTablet10 mg/1OralREMEDYREPACK INC.2011-07-25Not applicableUs
SimvastatinTablet, film coated40 mg/1OralKAISER FOUNDATION HOSPITALS2016-09-28Not applicableUs
SimvastatinTablet, film coated80 mg/1OralIngenus Pharmaceuticals, LLC2012-01-04Not applicableUs
SimvastatinTablet, film coated40 mg/1OralLegacy Pharmaceutical Packaging, Llc2015-12-02Not applicableUs
SimvastatinTablet, film coated10 mg/1OralState of Florida DOH Central Pharmacy2014-01-01Not applicableUs
SimvastatinTablet, film coated80 mg/1OralDr. Reddy's Laboratories Limited2006-12-20Not applicableUs
SimvastatinTablet, film coated40 mg/1OralPd Rx Pharmaceuticals, Inc.2011-06-13Not applicableUs
SimvastatinTablet, film coated10 mg/1OralRanbaxy Pharmaceuticals Inc.2006-12-20Not applicableUs
SimvastatinTablet, film coated10 mg/1OralSt Marys Medical Park Pharmacy2014-04-21Not applicableUs
SimvastatinTablet, film coated5 mg/1OralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2008-03-31Not applicableUs
SimvastatinTablet, film coated5 mg/1OralCadila Healthcare Limited2006-12-20Not applicableUs
SimvastatinTablet, film coated80 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2006-12-20Not applicableUs
SimvastatinTablet, film coated40 mg/1OralContract Pharmacy Services Pa2010-06-17Not applicableUs
SimvastatinTablet20 mg/1OralLegacy Pharmaceutical Packaging2010-10-01Not applicableUs
SimvastatinTablet, film coated40 mg/1OralAurolife Pharma LLC2009-11-09Not applicableUs
SimvastatinTablet, film coated80 mg/1OralAccord Healthcare, Inc.2008-02-26Not applicableUs
SimvastatinTablet, film coated40 mg/1OralBlu Pharmceuticals Llc2011-10-17Not applicableUs
SimvastatinTablet, film coated80 mg/1OralLUPIN LIMITED2015-11-23Not applicableUs
SimvastatinTablet, film coated40 mg/1OralRebel Distributors Corp2008-02-26Not applicableUs
SimvastatinTablet, film coated10 mg/1OralREMEDYREPACK INC.2011-01-20Not applicableUs
SimvastatinTablet, film coated20 mg/1OralAphena Pharma Solutions Tennessee, Llc2006-12-20Not applicableUs
SimvastatinTablet, film coated80 mg/1OralAmerican Health Packaging2011-05-022017-06-30Us
SimvastatinTablet, film coated80 mg/1OralAv Pak2014-12-02Not applicableUs
SimvastatinTablet, film coated80 mg/1OralA S Medication Solutions2008-02-26Not applicableUs
SimvastatinTablet, film coated20 mg/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
SimvastatinTablet, film coated40 mg/1OralUnit Dose Services2008-02-26Not applicableUs
SimvastatinTablet40 mg/1OralPhysicians Total Care, Inc.2008-07-08Not applicableUs
SimvastatinTablet, film coated20 mg/1OralCardinal Health2013-04-04Not applicableUs
SimvastatinTablet5 mg/1OralMicro Labs Limited2013-06-13Not applicableUs
SimvastatinTablet, film coated20 mg/1OralInternational Laboratories, Inc.2010-11-27Not applicableUs
SimvastatinTablet40 mg/1OralREMEDYREPACK INC.2011-04-142016-10-13Us
SimvastatinTablet, film coated40 mg/1OralPreferred Pharmaceuticals, Inc.2012-02-28Not applicableUs
SimvastatinTablet, film coated10 mg/1OralIngenus Pharmaceuticals, LLC2012-01-04Not applicableUs
SimvastatinTablet, film coated40 mg/1OralA S Medication Solutions2008-02-26Not applicableUs
SimvastatinTablet, film coated20 mg/1OralState of Florida DOH Central Pharmacy2014-01-01Not applicableUs
SimvastatinTablet, film coated20 mg/1OralRed Pharm Drug, Inc.2008-02-26Not applicableUs
SimvastatinTablet, film coated10 mg/1OralDr. Reddy's Laboratories Limited2006-12-20Not applicableUs
SimvastatinTablet, film coated5 mg/1OralCardinal Health2011-10-17Not applicableUs
SimvastatinTablet, film coated10 mg/1OralProficient Rx LP2008-02-26Not applicableUs
SimvastatinTablet, film coated5 mg/1OralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2013-01-17Not applicableUs
SimvastatinTablet, film coated80 mg/1OralCadila Healthcare Limited2006-12-20Not applicableUs
SimvastatinTablet, film coated40 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2012-06-14Not applicableUs
SimvastatinTablet, film coated80 mg/1OralLupin Pharmaceuticals, Inc.2015-12-02Not applicableUs
SimvastatinTablet40 mg/1OralLegacy Pharmaceutical Packaging, Llc2007-06-01Not applicableUs
SimvastatinTablet20 mg/1OralCobalt Laboratories Inc.2006-12-20Not applicableUs
SimvastatinTablet20 mg/1OralRebel Distributors Corp2008-07-21Not applicableUs
SimvastatinTablet, film coated20 mg/1OralCamber Pharmaceuticals, Inc.2014-12-09Not applicableUs
SimvastatinTablet, film coated40 mg/1OralPd Rx Pharmaceuticals, Inc.2015-08-12Not applicableUs
SimvastatinTablet, film coated5 mg/1OralBlu Pharmceuticals Llc2011-10-17Not applicableUs
SimvastatinTablet, film coated10 mg/1OralLUPIN LIMITED2007-06-12Not applicableUs
SimvastatinTablet, film coated10 mg/1OralLake Erie Medical DBA Quality Care Products LLC2008-02-26Not applicableUs
SimvastatinTablet, film coated20 mg/1OralTeva Pharmaceuticals USA Inc2006-06-27Not applicableUs
SimvastatinTablet, film coated40 mg/1OralAphena Pharma Solutions Tennessee, Llc2006-12-20Not applicableUs
SimvastatinTablet, film coated10 mg/1OralAmerican Health Packaging2011-05-02Not applicableUs
SimvastatinTablet, film coated10 mg/1OralAv Pak2014-12-02Not applicableUs
SimvastatinTablet, film coated40 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2015-12-02Not applicableUs
SimvastatinTablet, film coated40 mg/1OralH.J. Harkins Company, Inc.2008-02-26Not applicableUs
SimvastatinTablet, film coated80 mg/1OralBiocon Pharma Inc,2015-12-17Not applicableUs
SimvastatinTablet, film coated10 mg/1OralInternational Labs, Inc.2013-09-01Not applicableUs
SimvastatinTablet, film coated10 mg/1OralCardinal Health2006-12-20Not applicableUs
SimvastatinTablet, film coated20 mg/1OralSt Marys Medical Park Pharmacy2008-02-26Not applicableUs
SimvastatinTablet, film coated10 mg/1Oralbryant ranch prepack2008-02-26Not applicableUs
SimvastatinTablet, film coated20 mg/1OralBiocon Limited2015-12-17Not applicableUs
SimvastatinTablet, film coated20 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2006-12-20Not applicableUs
SimvastatinTablet, film coated40 mg/1OralMed Vantx, Inc.2006-12-20Not applicableUs
SimvastatinTablet, film coated20 mg/1OralZydus Pharmaceuticals (USA) Inc.2006-12-20Not applicableUs
SimvastatinTablet, film coated5 mg/1OralAurolife Pharma LLC2009-11-09Not applicableUs
SimvastatinTablet, film coated10 mg/1OralAccord Healthcare, Inc.2008-02-26Not applicableUs
SimvastatinTablet, film coated40 mg/1OralMc Kesson Contract Packaging2012-10-26Not applicableUs
SimvastatinTablet, film coated20 mg/1OralRanbaxy Pharmaceuticals Inc.2006-12-20Not applicableUs
SimvastatinTablet, film coated20 mg/1OralReady Meds2008-02-26Not applicableUs
SimvastatinTablet, film coated40 mg/1OralAurobindo Pharma Limited2006-12-20Not applicableUs
SimvastatinTablet, film coated20 mg/1OralBlenheim Pharmacal, Inc.2014-02-10Not applicableUs
SimvastatinTablet, film coated80 mg/1OralLupin Pharmaceuticals, Inc.2007-06-12Not applicableUs
SimvastatinTablet, film coated40 mg/1OralLife Line Home Care Services, Inc.2006-12-20Not applicableUs
SimvastatinTablet, film coated10 mg/1OralNorth Star Rx Llc2006-12-20Not applicableUs
SimvastatinTablet, film coated10 mg/1OralBlu Pharmaceuticals, LLC2008-02-01Not applicableUs
SimvastatinTablet, film coated40 mg/1OralLucid Pharma Llc2006-12-20Not applicableUs
SimvastatinTablet, film coated40 mg/1OralAidarex Pharmaceuticals LLC2008-02-26Not applicableUs
SimvastatinTablet20 mg/1OralCardinal Health2011-05-02Not applicableUs
SimvastatinTablet80 mg/1OralMicro Labs Limited2013-06-13Not applicableUs
SimvastatinTablet, film coated10 mg/1OralCardinal Health2006-12-20Not applicableUs
SimvastatinTablet40 mg/1OralREMEDYREPACK INC.2011-08-01Not applicableUs
SimvastatinTablet, film coated20 mg/1OralKAISER FOUNDATION HOSPITALS2016-09-28Not applicableUs
SimvastatinTablet, film coated10 mg/1OralMylan Institutional Inc.2006-07-10Not applicableUs
SimvastatinTablet, film coated5 mg/1OralBiocon Pharma Inc,2015-12-17Not applicableUs
SimvastatinTablet, film coated40 mg/1OralState of Florida DOH Central Pharmacy2014-01-01Not applicableUs
SimvastatinTablet, film coated20 mg/1OralCardinal Health2008-02-26Not applicableUs
SimvastatinTablet, film coated20 mg/1OralLake Erie Medical DBA Quality Care Products LLC2012-03-29Not applicableUs
SimvastatinTablet, film coated20 mg/1OralREMEDYREPACK INC.2015-03-25Not applicableUs
SimvastatinTablet, film coated10 mg/1OralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2008-03-31Not applicableUs
SimvastatinTablet, film coated10 mg/1OralCadila Healthcare Limited2006-12-20Not applicableUs
SimvastatinTablet, film coated5 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2006-12-20Not applicableUs
SimvastatinTablet, film coated5 mg/1OralContract Pharmacy Services Pa2010-08-25Not applicableUs
SimvastatinTablet40 mg/1OralLegacy Pharmaceutical Packaging2010-10-01Not applicableUs
SimvastatinTablet, film coated80 mg/1OralAurolife Pharma LLC2009-11-09Not applicableUs
SimvastatinTablet, film coated5 mg/1OralAccord Healthcare, Inc.2013-09-02Not applicableUs
SimvastatinTablet, film coated80 mg/1OralBlu Pharmceuticals Llc2011-10-17Not applicableUs
SimvastatinTablet, film coated5 mg/1OralLUPIN LIMITED2009-07-14Not applicableUs
SimvastatinTablet, film coated20 mg/1OralRebel Distributors Corp2008-02-26Not applicableUs
SimvastatinTablet40 mg/1OralREMEDYREPACK INC.2010-12-30Not applicableUs
SimvastatinTablet, film coated5 mg/1OralAphena Pharma Solutions Tennessee, Llc2006-12-20Not applicableUs
SimvastatinTablet, film coated40 mg/1OralPreferred Pharmaceuticals, Inc.2014-07-03Not applicableUs
SimvastatinTablet, film coated20 mg/1OralUnit Dose Services2008-02-26Not applicableUs
SimvastatinTablet, film coated10 mg/1OralA S Medication Solutions2008-02-26Not applicableUs
SimvastatinTablet, film coated20 mg/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
SimvastatinTablet, film coated40 mg/1OralAmerican Health Packaging2016-06-20Not applicableUs
SimvastatinTablet80 mg/1OralPhysicians Total Care, Inc.2007-05-23Not applicableUs
SimvastatinTablet, film coated20 mg/1OralCardinal Health2011-10-03Not applicableUs
SimvastatinTablet40 mg/1OralRebel Distributors Corp2008-07-08Not applicableUs
SimvastatinTablet, film coated5 mg/1OralLucid Pharma Llc2006-12-20Not applicableUs
SimvastatinTablet, film coated40 mg/1OralCamber Pharmaceuticals, Inc.2014-12-03Not applicableUs
SimvastatinTablet20 mg/1OralREMEDYREPACK INC.2011-12-08Not applicableUs
SimvastatinTablet10 mg/1OralMicro Labs Limited2013-06-13Not applicableUs
SimvastatinTablet, film coated10 mg/1OralInternational Laboratories, Inc.2010-11-28Not applicableUs
SimvastatinTablet40 mg/1OralREMEDYREPACK INC.2011-07-082016-10-13Us
SimvastatinTablet, film coated20 mg/1OralPreferred Pharmaceuticals, Inc.2012-02-28Not applicableUs
SimvastatinTablet, film coated20 mg/1OralIngenus Pharmaceuticals, LLC2012-01-04Not applicableUs
SimvastatinTablet, film coated80 mg/1OralA S Medication Solutions2008-02-26Not applicableUs
SimvastatinTablet, film coated5 mg/1OralState of Florida DOH Central Pharmacy2014-01-01Not applicableUs
SimvastatinTablet, film coated20 mg/1OralUnit Dose Services2008-02-26Not applicableUs
SimvastatinTablet, film coated20 mg/1OralDr. Reddy's Laboratories Limited2006-12-20Not applicableUs
SimvastatinTablet, film coated20 mg/1OralPd Rx Pharmaceuticals, Inc.2011-06-13Not applicableUs
SimvastatinTablet, film coated40 mg/1OralProficient Rx LP2008-02-26Not applicableUs
SimvastatinTablet, film coated10 mg/1OralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2012-12-20Not applicableUs
SimvastatinTablet, film coated5 mg/1OralAurobindo Pharma Limited2006-12-20Not applicableUs
SimvastatinTablet, film coated10 mg/1OralMajor Pharmaceuticals2006-12-20Not applicableUs
SimvastatinTablet, film coated10 mg/1OralLupin Pharmaceuticals, Inc.2007-06-12Not applicableUs
SimvastatinTablet80 mg/1OralLegacy Pharmaceutical Packaging, Llc2007-06-01Not applicableUs
SimvastatinTablet40 mg/1OralCobalt Laboratories Inc.2006-12-20Not applicableUs
SimvastatinTablet, film coated40 mg/1OralZydus Pharmaceuticals (USA) Inc.2006-12-20Not applicableUs
SimvastatinTablet, film coated10 mg/1OralAurolife Pharma LLC2009-11-09Not applicableUs
SimvastatinTablet, film coated20 mg/1OralAccord Healthcare, Inc.2008-02-26Not applicableUs
SimvastatinTablet, film coated40 mg/1OralMc Kesson Contract Packaging2013-02-19Not applicableUs
SimvastatinTablet, film coated10 mg/1OralBlu Pharmceuticals Llc2011-10-17Not applicableUs
SimvastatinTablet, film coated20 mg/1OralLUPIN LIMITED2007-06-14Not applicableUs
SimvastatinTablet, film coated40 mg/1OralLake Erie Medical DBA Quality Care Products LLC2008-02-26Not applicableUs
SimvastatinTablet, film coated40 mg/1OralTeva Pharmaceuticals USA Inc2006-06-27Not applicableUs
SimvastatinTablet, film coated80 mg/1OralAphena Pharma Solutions Tennessee, Llc2006-12-20Not applicableUs
SimvastatinTablet, film coated20 mg/1OralAmerican Health Packaging2011-05-02Not applicableUs
SimvastatinTablet, film coated20 mg/1OralAv Pak2014-12-02Not applicableUs
SimvastatinTablet, film coated20 mg/1OralA S Medication Solutions2008-02-26Not applicableUs
SimvastatinTablet, film coated20 mg/1OralH.J. Harkins Company, Inc.2008-02-26Not applicableUs
SimvastatinTablet, film coated10 mg/1OralUnit Dose Services2008-02-26Not applicableUs
SimvastatinTablet10 mg/1OralPhysicians Total Care, Inc.2007-02-02Not applicableUs
SimvastatinTablet, film coated5 mg/1OralCardinal Health2006-06-27Not applicableUs
SimvastatinTablet, film coated40 mg/1OralSt Marys Medical Park Pharmacy2008-02-26Not applicableUs
SimvastatinTablet, film coated20 mg/1Oralbryant ranch prepack2008-02-26Not applicableUs
SimvastatinTablet, film coated40 mg/1OralBiocon Limited2015-12-17Not applicableUs
SimvastatinTablet, film coated40 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2006-12-20Not applicableUs
SimvastatinTablet, film coated20 mg/1OralContract Pharmacy Services Pa2010-06-17Not applicableUs
SimvastatinTablet, film coated40 mg/1OralRanbaxy Pharmaceuticals Inc.2006-12-20Not applicableUs
SimvastatinTablet, film coated40 mg/1OralReady Meds2008-02-26Not applicableUs
SimvastatinTablet, film coated80 mg/1OralAurobindo Pharma Limited2006-12-20Not applicableUs
SimvastatinTablet, film coated40 mg/1OralBlenheim Pharmacal, Inc.2015-02-27Not applicableUs
SimvastatinTablet, film coated5 mg/1OralLupin Pharmaceuticals, Inc.2009-07-14Not applicableUs
SimvastatinTablet, film coated10 mg/1OralMc Kesson Contract Packaging2011-10-13Not applicableUs
SimvastatinTablet, film coated20 mg/1OralNorth Star Rx Llc2006-12-20Not applicableUs
SimvastatinTablet, film coated20 mg/1OralBlu Pharmaceuticals, LLC2008-02-01Not applicableUs
SimvastatinTablet, film coated80 mg/1OralLucid Pharma Llc2006-12-20Not applicableUs
SimvastatinTablet, film coated10 mg/1OralAidarex Pharmaceuticals LLC2008-02-26Not applicableUs
SimvastatinTablet, film coated80 mg/1OralAvera Mc Kennan Hospital2015-12-02Not applicableUs
SimvastatinTablet, film coated80 mg/1OralPd Rx Pharmaceuticals, Inc.2006-12-20Not applicableUs
SimvastatinTablet10 mg/1OralClinical Solutions Wholesale2007-06-01Not applicableUs
SimvastatinTablet, film coated20 mg/1OralREMEDYREPACK INC.2013-05-142016-10-13Us
SimvastatinTablet, film coated10 mg/1OralKAISER FOUNDATION HOSPITALS2016-09-28Not applicableUs
SimvastatinTablet, film coated20 mg/1OralMylan Institutional Inc.2006-07-10Not applicableUs
SimvastatinTablet, film coated10 mg/1OralBiocon Pharma Inc,2015-12-17Not applicableUs
SimvastatinTablet, film coated10 mg/1OralState of Florida DOH Central Pharmacy2014-11-01Not applicableUs
SimvastatinTablet, film coated20 mg/1OralCardinal Health2006-12-20Not applicableUs
SimvastatinTablet, film coated20 mg/1OralClinical Solutions Wholesale2008-02-26Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
CholestatKalbe
ColeminBiohorm
LabistatinSandoz
LipexMerck Sharp & Dohme
LodalesSanofi-Aventis
MedipoMediolanum Farmaceutici
NivelipolTemis-Lostalo
SimovilMerck Sharp & Dohme
SinvacorMerck Sharp & Dohme
SivastinSigma-Tau
SivatinRowex
SivinarAnfarm
SorfoxGalex
SotovastinBros
StarezinLeovan Pharmaceuticals
StarstatLupin
StarzokoDaewoong
StasivaPharmanel
StatexPliva
StaticorDarnitsa
StatinalAlet Pharmaceuticals
StativerIapharm
Brand mixtures
NameLabellerIngredients
SimcorPhysicians Total Care, Inc.
VytorinRebel Distributors Corp
SaltsNot Available
Categories
UNIIAGG2FN16EV
CAS number79902-63-9
WeightAverage: 418.5662
Monoisotopic: 418.271924326
Chemical FormulaC25H38O5
InChI KeyRYMZZMVNJRMUDD-HGQWONQESA-N
InChI
InChI=1S/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23-/m0/s1
IUPAC Name
(1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate
SMILES
[H][C@]12[[email protected]](C[C@@H](C)C=C1C=C[[email protected]](C)[C@@H]2CC[C@@H]1C[C@@H](O)CC(=O)O1)OC(=O)C(C)(C)CC
Pharmacology
IndicationFor the treatment of hypercholesterolemia and for the reduction in the risk of cardiac heart disease mortality and cardiovascular events. It can also be used in adolescent patients for the treatment of heterozygous familial hypercholesterolemia.
Structured Indications
PharmacodynamicsSimvastatin, the methylated form of lovastatin, is an oral antilipemic agent which inhibits HMG-CoA reductase. Simvastatin is used in the treatment of primary hypercholesterolemia and is effective in reducing total and LDL-cholesterol as well as plasma triglycerides and apolipoprotein B.
Mechanism of actionSimvastatin is a prodrug in which the 6-membered lactone ring of simvastatin is hydrolyzed in vivo to generate the beta,delta-dihydroxy acid, an active metabolite structurally similar to HMG-CoA (hydroxymethylglutaryl CoA). Once hydrolyzed, simvastatin competes with HMG-CoA for HMG-CoA reductase, a hepatic microsomal enzyme. Interference with the activity of this enzyme reduces the quantity of mevalonic acid, a precursor of cholesterol.
TargetKindPharmacological actionActionsOrganismUniProt ID
3-hydroxy-3-methylglutaryl-coenzyme A reductaseProteinyes
inhibitor
HumanP04035 details
Integrin beta-2Proteinno
other
HumanP05107 details
Related Articles
AbsorptionAbsorption of simvastatin, estimated relative to an intravenous reference dose, in each of two animal species tested, averaged about 85% of an oral dose. In animal studies, after oral dosing, simvastatin achieved substantially higher concentrations in the liver than in non-target tissues. However, because simvastatin undergoes extensive first-pass metabolism, the availability of the drug in the systemic is low. Peak plasma concentration occurs 1.3 - 2.4 hours after administration.
Volume of distribution

Simvastatin can cross the blood-brain-barrier.

Protein bindingBoth simvastatin and its β-hydroxyacid metabolite are highly bound (approximately 95%) to human plasma proteins.
Metabolism

Hepatic, simvastatin is a substrate for CYP3A4. The major active metabolites of simvastatin are β-hydroxyacid metabolite and its 6'-hydroxy, 6'-hydroxymethyl, and 6'-exomethylene derivatives

SubstrateEnzymesProduct
Simvastatin
simvastatin hydroxy acidDetails
Route of eliminationFollowing an oral dose of 14C-labeled simvastatin in man, 13% of the dose was excreted in urine and 60% in feces.
Half life3 hours
ClearanceNot Available
ToxicityThe most common adverse reactions that lead to discontinuation of therapy include gastrointestinal disorders (0.5%), myalgia (0.1%), and arthralgia (0.1%).
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Simvastatin Action PathwayDrug actionSMP00082
SNP Mediated Effects
Interacting Gene/EnzymeSNP RS IDAllele nameDefining changeEffectReference(s)
Kinesin-like protein KIF6
Gene symbol: KIF6
UniProt: Q6ZMV9
rs20455 Not AvailableC AlleleImproved response to statin drugs18222353
3-hydroxy-3-methylglutaryl-coenzyme A reductase
Gene symbol: HMGCR
UniProt: P04035
rs17244841 Not AvailableT AlleleReduced response to statin drugs15199031
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
1,10-PhenanthrolineThe serum concentration of Simvastatin can be increased when it is combined with 1,10-Phenanthroline.Experimental
3,4-DichloroisocoumarinThe serum concentration of Simvastatin can be increased when it is combined with 3,4-Dichloroisocoumarin.Experimental
4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDEThe serum concentration of Simvastatin can be increased when it is combined with 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE.Experimental
AbirateroneThe serum concentration of Simvastatin can be increased when it is combined with Abiraterone.Approved
AcebutololThe serum concentration of Acebutolol can be increased when it is combined with Simvastatin.Approved
AcenocoumarolSimvastatin may increase the anticoagulant activities of Acenocoumarol.Approved
AcetaminophenThe serum concentration of Acetaminophen can be increased when it is combined with Simvastatin.Approved
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Simvastatin.Approved, Vet Approved
AcipimoxAcipimox may increase the myopathic rhabdomyolysis activities of Simvastatin.Approved
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Simvastatin.Approved
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Simvastatin.Experimental
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Simvastatin.Approved, Investigational
AlogliptinThe serum concentration of Simvastatin can be increased when it is combined with Alogliptin.Approved
Alpha-1-proteinase inhibitorThe serum concentration of Simvastatin can be increased when it is combined with Alpha-1-proteinase inhibitor.Approved
Aluminum hydroxideThe serum concentration of Simvastatin can be decreased when it is combined with Aluminum hydroxide.Approved
Aluminum phosphateThe serum concentration of Simvastatin can be decreased when it is combined with Aluminum phosphate.Approved
AmbrisentanThe serum concentration of Ambrisentan can be increased when it is combined with Simvastatin.Approved, Investigational
AmiodaroneThe serum concentration of Simvastatin can be increased when it is combined with Amiodarone.Approved, Investigational
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Simvastatin.Approved
AmlodipineThe serum concentration of Simvastatin can be increased when it is combined with Amlodipine.Approved
AmodiaquineThe serum concentration of Amodiaquine can be increased when it is combined with Simvastatin.Approved
AmprenavirThe serum concentration of Simvastatin can be increased when it is combined with Amprenavir.Approved
Antithrombin III humanThe serum concentration of Simvastatin can be increased when it is combined with Antithrombin III human.Approved
ApixabanThe serum concentration of Simvastatin can be increased when it is combined with Apixaban.Approved
AprepitantThe serum concentration of Simvastatin can be increased when it is combined with Aprepitant.Approved, Investigational
AprotininThe serum concentration of Simvastatin can be increased when it is combined with Aprotinin.Approved, Withdrawn
ArgatrobanThe serum concentration of Simvastatin can be increased when it is combined with Argatroban.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be decreased when it is combined with Simvastatin.Approved, Investigational
Arsenic trioxideThe serum concentration of Arsenic trioxide can be increased when it is combined with Simvastatin.Approved, Investigational
ArtemetherThe metabolism of Simvastatin can be decreased when combined with Artemether.Approved
AsunaprevirThe serum concentration of Simvastatin can be increased when it is combined with Asunaprevir.Approved, Investigational
AtazanavirThe serum concentration of Simvastatin can be increased when it is combined with Atazanavir.Approved, Investigational
AtenololThe serum concentration of Atenolol can be increased when it is combined with Simvastatin.Approved
AtomoxetineThe metabolism of Simvastatin can be decreased when combined with Atomoxetine.Approved
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Simvastatin.Approved, Investigational
AzithromycinAzithromycin may increase the myopathic rhabdomyolysis activities of Simvastatin.Approved
BatimastatThe serum concentration of Simvastatin can be increased when it is combined with Batimastat.Experimental
BenazeprilThe serum concentration of Simvastatin can be increased when it is combined with Benazepril.Approved, Investigational
BenzamidineThe serum concentration of Simvastatin can be increased when it is combined with Benzamidine.Experimental
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Simvastatin.Approved, Vet Approved
BetaxololThe metabolism of Simvastatin can be decreased when combined with Betaxolol.Approved
BexaroteneThe serum concentration of Simvastatin can be decreased when it is combined with Bexarotene.Approved, Investigational
BezafibrateBezafibrate may increase the myopathic rhabdomyolysis activities of Simvastatin.Approved
Bi201335The serum concentration of Simvastatin can be increased when it is combined with Bi201335.Investigational
Bismuth SubcitrateThe serum concentration of Simvastatin can be decreased when it is combined with Bismuth Subcitrate.Approved
BivalirudinThe serum concentration of Simvastatin can be increased when it is combined with Bivalirudin.Approved, Investigational
BoceprevirThe serum concentration of Simvastatin can be increased when it is combined with Boceprevir.Approved
BortezomibThe metabolism of Simvastatin can be decreased when combined with Bortezomib.Approved, Investigational
BosentanThe metabolism of Simvastatin can be increased when combined with Bosentan.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Simvastatin.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Simvastatin.Approved
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Simvastatin.Approved, Investigational
BupropionThe metabolism of Simvastatin can be decreased when combined with Bupropion.Approved
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Simvastatin.Approved
CaffeineThe serum concentration of Caffeine can be increased when it is combined with Simvastatin.Approved
Calcium carbonateThe serum concentration of Simvastatin can be decreased when it is combined with Calcium carbonate.Approved
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Simvastatin.Experimental
CanagliflozinThe serum concentration of Canagliflozin can be increased when it is combined with Simvastatin.Approved
CandoxatrilThe serum concentration of Simvastatin can be increased when it is combined with Candoxatril.Experimental
CandoxatrilatThe serum concentration of Simvastatin can be increased when it is combined with Candoxatrilat.Experimental
CaptoprilThe serum concentration of Simvastatin can be increased when it is combined with Captopril.Approved
CarbamazepineThe metabolism of Simvastatin can be increased when combined with Carbamazepine.Approved, Investigational
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Simvastatin.Approved
CelecoxibThe metabolism of Simvastatin can be decreased when combined with Celecoxib.Approved, Investigational
CeritinibThe serum concentration of Simvastatin can be increased when it is combined with Ceritinib.Approved
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Simvastatin.Withdrawn
ChloroquineThe metabolism of Simvastatin can be decreased when combined with Chloroquine.Approved, Vet Approved
ChlorpromazineThe serum concentration of Chlorpromazine can be increased when it is combined with Simvastatin.Approved, Vet Approved
CholecalciferolThe metabolism of Simvastatin can be decreased when combined with Cholecalciferol.Approved, Nutraceutical
ChymostatinThe serum concentration of Simvastatin can be increased when it is combined with Chymostatin.Experimental
CilastatinThe serum concentration of Simvastatin can be increased when it is combined with Cilastatin.Approved
CilazaprilThe serum concentration of Simvastatin can be increased when it is combined with Cilazapril.Approved
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Simvastatin.Approved
CimetidineThe serum concentration of Cimetidine can be increased when it is combined with Simvastatin.Approved
CinacalcetThe metabolism of Simvastatin can be decreased when combined with Cinacalcet.Approved
CiprofibrateThe risk or severity of adverse effects can be increased when Ciprofibrate is combined with Simvastatin.Approved
CiprofloxacinThe serum concentration of Ciprofloxacin can be increased when it is combined with Simvastatin.Approved, Investigational
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Simvastatin.Approved
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Simvastatin.Approved
ClarithromycinThe serum concentration of Simvastatin can be increased when it is combined with Clarithromycin.Approved
ClemastineThe metabolism of Simvastatin can be decreased when combined with Clemastine.Approved
ClobazamThe serum concentration of Clobazam can be increased when it is combined with Simvastatin.Approved, Illicit
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Simvastatin.Approved, Investigational
ClomipramineThe metabolism of Simvastatin can be decreased when combined with Clomipramine.Approved, Vet Approved
ClonidineThe serum concentration of Clonidine can be increased when it is combined with Simvastatin.Approved
ClopidogrelThe metabolism of Simvastatin can be decreased when combined with Clopidogrel.Approved, Nutraceutical
ClotrimazoleThe metabolism of Simvastatin can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineThe serum concentration of Clozapine can be increased when it is combined with Simvastatin.Approved
CobicistatThe serum concentration of Simvastatin can be increased when it is combined with Cobicistat.Approved
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Simvastatin.Approved
CocaineThe metabolism of Simvastatin can be decreased when combined with Cocaine.Approved, Illicit
ColchicineColchicine may increase the myopathic rhabdomyolysis activities of Simvastatin.Approved
ConivaptanThe serum concentration of Simvastatin can be increased when it is combined with Conivaptan.Approved, Investigational
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be increased when it is combined with Simvastatin.Approved
CrizotinibThe metabolism of Simvastatin can be decreased when combined with Crizotinib.Approved
CyclosporineThe serum concentration of Simvastatin can be increased when it is combined with Cyclosporine.Approved, Investigational, Vet Approved
CyclosporineThe metabolism of Simvastatin can be decreased when combined with Cyclosporine.Approved, Investigational, Vet Approved
Cyproterone acetateThe serum concentration of Simvastatin can be increased when it is combined with Cyproterone acetate.Approved, Investigational
Dabigatran etexilateThe serum concentration of Simvastatin can be increased when it is combined with Dabigatran etexilate.Approved
DabrafenibThe serum concentration of Simvastatin can be decreased when it is combined with Dabrafenib.Approved
DaclatasvirThe serum concentration of Simvastatin can be increased when it is combined with Daclatasvir.Approved
DactinomycinThe serum concentration of Dactinomycin can be increased when it is combined with Simvastatin.Approved
DanazolThe serum concentration of Simvastatin can be increased when it is combined with Danazol.Approved
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Simvastatin.Approved
DaptomycinThe risk or severity of adverse effects can be increased when Simvastatin is combined with Daptomycin.Approved, Investigational
DarifenacinThe metabolism of Simvastatin can be decreased when combined with Darifenacin.Approved, Investigational
DarunavirThe serum concentration of Simvastatin can be increased when it is combined with Darunavir.Approved
DasatinibThe serum concentration of Simvastatin can be increased when it is combined with Dasatinib.Approved, Investigational
DaunorubicinThe serum concentration of Daunorubicin can be increased when it is combined with Simvastatin.Approved
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Simvastatin.Approved
DeferasiroxThe serum concentration of Simvastatin can be decreased when it is combined with Deferasirox.Approved, Investigational
DelavirdineThe metabolism of Simvastatin can be decreased when combined with Delavirdine.Approved
DesipramineThe metabolism of Simvastatin can be decreased when combined with Desipramine.Approved
DexamethasoneThe serum concentration of Simvastatin can be decreased when it is combined with Dexamethasone.Approved, Investigational, Vet Approved
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Simvastatin.Approved, Illicit, Vet Approved
DicoumarolSimvastatin may increase the anticoagulant activities of Dicoumarol.Approved
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Simvastatin.Approved
DigitoxinThe serum concentration of Digitoxin can be increased when it is combined with Simvastatin.Approved
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Simvastatin.Approved
DihydroergotamineThe metabolism of Simvastatin can be decreased when combined with Dihydroergotamine.Approved
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Simvastatin.Illicit
DiltiazemThe serum concentration of Diltiazem can be increased when it is combined with Simvastatin.Approved
DiphenhydramineThe metabolism of Simvastatin can be decreased when combined with Diphenhydramine.Approved
DipyridamoleThe serum concentration of Dipyridamole can be increased when it is combined with Simvastatin.Approved
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with Simvastatin.Approved, Investigational
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Simvastatin.Approved, Investigational, Vet Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Simvastatin.Approved, Investigational
DoxycyclineThe metabolism of Simvastatin can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DronedaroneThe serum concentration of Simvastatin can be increased when it is combined with Dronedarone.Approved
DuloxetineThe metabolism of Simvastatin can be decreased when combined with Duloxetine.Approved
EcabetThe serum concentration of Simvastatin can be increased when it is combined with Ecabet.Approved, Investigational
EdoxabanThe serum concentration of Simvastatin can be increased when it is combined with Edoxaban.Approved
EfavirenzThe serum concentration of Simvastatin can be decreased when it is combined with Efavirenz.Approved, Investigational
ElafinThe serum concentration of Simvastatin can be increased when it is combined with Elafin.Investigational
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Simvastatin.Approved, Investigational
EliglustatThe metabolism of Simvastatin can be decreased when combined with Eliglustat.Approved
EltrombopagThe serum concentration of Simvastatin can be increased when it is combined with Eltrombopag.Approved
EnalaprilThe serum concentration of Simvastatin can be increased when it is combined with Enalapril.Approved, Vet Approved
EnalaprilatThe serum concentration of Simvastatin can be increased when it is combined with Enalaprilat.Approved
EnalkirenThe serum concentration of Simvastatin can be increased when it is combined with Enalkiren.Experimental
EnzalutamideThe serum concentration of Simvastatin can be decreased when it is combined with Enzalutamide.Approved
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Simvastatin.Approved, Investigational
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Simvastatin.Approved, Investigational
ErythromycinThe serum concentration of Simvastatin can be increased when it is combined with Erythromycin.Approved, Vet Approved
ErythromycinThe metabolism of Simvastatin can be decreased when combined with Erythromycin.Approved, Vet Approved
Eslicarbazepine acetateThe serum concentration of Simvastatin can be decreased when it is combined with Eslicarbazepine acetate.Approved
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Simvastatin.Approved, Investigational, Vet Approved
EstriolThe serum concentration of Estriol can be increased when it is combined with Simvastatin.Approved, Vet Approved
EstroneThe serum concentration of Estrone can be increased when it is combined with Simvastatin.Approved
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Simvastatin.Approved
Ethyl biscoumacetateSimvastatin may increase the anticoagulant activities of Ethyl biscoumacetate.Withdrawn
EtoposideThe serum concentration of Etoposide can be increased when it is combined with Simvastatin.Approved
EtravirineThe serum concentration of Simvastatin can be decreased when it is combined with Etravirine.Approved
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Simvastatin.Approved
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Simvastatin.Approved
FelodipineThe metabolism of Simvastatin can be decreased when combined with Felodipine.Approved, Investigational
FenofibrateThe risk or severity of adverse effects can be increased when Fenofibrate is combined with Simvastatin.Approved
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Simvastatin.Approved
FexofenadineThe serum concentration of Fexofenadine can be increased when it is combined with Simvastatin.Approved
FidaxomicinThe serum concentration of Fidaxomicin can be increased when it is combined with Simvastatin.Approved
FluconazoleThe serum concentration of Simvastatin can be increased when it is combined with Fluconazole.Approved
FluindioneSimvastatin may increase the anticoagulant activities of Fluindione.Investigational
FluoxetineThe metabolism of Simvastatin can be decreased when combined with Fluoxetine.Approved, Vet Approved
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Simvastatin.Approved
FluvoxamineThe metabolism of Simvastatin can be decreased when combined with Fluvoxamine.Approved, Investigational
FosamprenavirThe serum concentration of Simvastatin can be increased when it is combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Simvastatin can be increased when it is combined with Fosaprepitant.Approved
FosinoprilThe serum concentration of Simvastatin can be increased when it is combined with Fosinopril.Approved
FosphenytoinThe serum concentration of Simvastatin can be decreased when it is combined with Fosphenytoin.Approved
Fusidic AcidThe serum concentration of Simvastatin can be increased when it is combined with Fusidic Acid.Approved
GabexateThe serum concentration of Simvastatin can be increased when it is combined with Gabexate.Investigational
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Simvastatin.Approved, Investigational
GeldanamycinThe serum concentration of Simvastatin can be increased when it is combined with Geldanamycin.Experimental
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Simvastatin.Approved
GemfibrozilGemfibrozil may increase the myopathic rhabdomyolysis activities of Simvastatin.Approved
GM6001The serum concentration of Simvastatin can be increased when it is combined with GM6001.Experimental
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Simvastatin.Approved
GrepafloxacinThe serum concentration of Grepafloxacin can be increased when it is combined with Simvastatin.Withdrawn
HaloperidolThe serum concentration of Haloperidol can be increased when it is combined with Simvastatin.Approved
HirulogThe serum concentration of Simvastatin can be increased when it is combined with Hirulog.Experimental
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with Simvastatin.Approved, Vet Approved
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Simvastatin.Approved
IdelalisibThe serum concentration of Simvastatin can be increased when it is combined with Idelalisib.Approved
idraparinuxThe serum concentration of Simvastatin can be increased when it is combined with idraparinux.Investigational
ImatinibThe metabolism of Simvastatin can be decreased when combined with Imatinib.Approved
ImidaprilThe serum concentration of Simvastatin can be increased when it is combined with Imidapril.Investigational
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Simvastatin.Approved
IndacaterolThe serum concentration of Indacaterol can be increased when it is combined with Simvastatin.Approved
IndinavirThe serum concentration of Simvastatin can be increased when it is combined with Indinavir.Approved
IndomethacinThe serum concentration of Indomethacin can be increased when it is combined with Simvastatin.Approved, Investigational
IrbesartanThe metabolism of Simvastatin can be decreased when combined with Irbesartan.Approved, Investigational
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Simvastatin.Approved, Investigational
IsavuconazoniumThe metabolism of Simvastatin can be decreased when combined with Isavuconazonium.Approved, Investigational
IsoflurophateThe serum concentration of Simvastatin can be increased when it is combined with Isoflurophate.Approved, Withdrawn
IsoniazidThe metabolism of Simvastatin can be decreased when combined with Isoniazid.Approved
IsradipineThe metabolism of Simvastatin can be decreased when combined with Isradipine.Approved
ItraconazoleThe serum concentration of Simvastatin can be increased when it is combined with Itraconazole.Approved, Investigational
IvacaftorThe serum concentration of Simvastatin can be increased when it is combined with Ivacaftor.Approved
IvermectinThe serum concentration of Ivermectin can be increased when it is combined with Simvastatin.Approved, Vet Approved
IxazomibThe serum concentration of Simvastatin can be increased when it is combined with Ixazomib.Approved
KetazolamThe serum concentration of Ketazolam can be increased when it is combined with Simvastatin.Approved
KetoconazoleThe serum concentration of Simvastatin can be increased when it is combined with Ketoconazole.Approved, Investigational
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Simvastatin.Approved, Investigational
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Simvastatin.Approved, Investigational
LansoprazoleThe serum concentration of Lansoprazole can be increased when it is combined with Simvastatin.Approved, Investigational
Lanthanum carbonateThe serum concentration of Lanthanum carbonate can be decreased when it is combined with Simvastatin.Approved
LapatinibThe metabolism of Simvastatin can be decreased when combined with Lapatinib.Approved, Investigational
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Simvastatin.Approved
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Simvastatin.Approved
LenvatinibThe serum concentration of Lenvatinib can be increased when it is combined with Simvastatin.Approved
LepirudinThe serum concentration of Simvastatin can be increased when it is combined with Lepirudin.Approved
LercanidipineThe serum concentration of Simvastatin can be increased when it is combined with Lercanidipine.Approved, Investigational
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Simvastatin.Approved, Investigational
LevofloxacinThe serum concentration of Levofloxacin can be increased when it is combined with Simvastatin.Approved, Investigational
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Simvastatin.Approved
LinagliptinThe serum concentration of Simvastatin can be increased when it is combined with Linagliptin.Approved
LisinoprilThe serum concentration of Simvastatin can be increased when it is combined with Lisinopril.Approved, Investigational
LomitapideThe serum concentration of Simvastatin can be increased when it is combined with Lomitapide.Approved
LoperamideThe serum concentration of Loperamide can be increased when it is combined with Simvastatin.Approved
LopinavirThe serum concentration of Simvastatin can be increased when it is combined with Lopinavir.Approved
LorcaserinThe metabolism of Simvastatin can be decreased when combined with Lorcaserin.Approved
LosartanThe serum concentration of Losartan can be increased when it is combined with Simvastatin.Approved
LovastatinThe metabolism of Simvastatin can be decreased when combined with Lovastatin.Approved, Investigational
LuliconazoleThe serum concentration of Simvastatin can be increased when it is combined with Luliconazole.Approved
LumacaftorThe serum concentration of Simvastatin can be increased when it is combined with Lumacaftor.Approved
LumefantrineThe metabolism of Simvastatin can be decreased when combined with Lumefantrine.Approved
MagaldrateThe serum concentration of Simvastatin can be decreased when it is combined with Magaldrate.Withdrawn
Magnesium carbonateThe serum concentration of Simvastatin can be decreased when it is combined with Magnesium carbonate.Approved
Magnesium hydroxideThe serum concentration of Simvastatin can be decreased when it is combined with Magnesium hydroxide.Approved
Magnesium oxideThe serum concentration of Simvastatin can be decreased when it is combined with Magnesium oxide.Approved
Magnesium TrisilicateThe serum concentration of Simvastatin can be decreased when it is combined with Magnesium Trisilicate.Approved
MannitolThe serum concentration of Mannitol can be increased when it is combined with Simvastatin.Approved, Investigational
MethadoneThe metabolism of Simvastatin can be decreased when combined with Methadone.Approved
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Simvastatin.Approved
MethotrimeprazineThe metabolism of Simvastatin can be decreased when combined with Methotrimeprazine.Approved
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Simvastatin.Approved, Vet Approved
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Simvastatin.Approved, Investigational
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Simvastatin.Approved, Illicit
MifepristoneThe serum concentration of Simvastatin can be increased when it is combined with Mifepristone.Approved, Investigational
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Simvastatin.Approved
MitotaneThe serum concentration of Simvastatin can be decreased when it is combined with Mitotane.Approved
MitoxantroneThe serum concentration of Mitoxantrone can be increased when it is combined with Simvastatin.Approved, Investigational
ModafinilThe serum concentration of Simvastatin can be decreased when it is combined with Modafinil.Approved, Investigational
MoexiprilThe serum concentration of Simvastatin can be increased when it is combined with Moexipril.Approved
MorphineThe serum concentration of Morphine can be increased when it is combined with Simvastatin.Approved, Investigational
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Simvastatin.Approved, Investigational
N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-ProlineThe serum concentration of Simvastatin can be increased when it is combined with N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-Proline.Experimental
NadololThe serum concentration of Nadolol can be increased when it is combined with Simvastatin.Approved
NafamostatThe serum concentration of Simvastatin can be increased when it is combined with Nafamostat.Investigational
NafcillinThe serum concentration of Simvastatin can be decreased when it is combined with Nafcillin.Approved
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Simvastatin.Approved
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Simvastatin.Approved, Vet Approved
NCX 4016The serum concentration of Simvastatin can be increased when it is combined with NCX 4016.Investigational
NefazodoneThe serum concentration of Simvastatin can be increased when it is combined with Nefazodone.Approved, Withdrawn
NelfinavirThe serum concentration of Simvastatin can be increased when it is combined with Nelfinavir.Approved
NetupitantThe serum concentration of Simvastatin can be increased when it is combined with Netupitant.Approved
NevirapineThe metabolism of Simvastatin can be increased when combined with Nevirapine.Approved
NiacinThe risk or severity of adverse effects can be increased when Niacin is combined with Simvastatin.Approved, Investigational, Nutraceutical
NicardipineThe serum concentration of Nicardipine can be increased when it is combined with Simvastatin.Approved
NicotinamideThe risk or severity of adverse effects can be increased when Nicotinamide is combined with Simvastatin.Approved
NifedipineThe serum concentration of Nifedipine can be increased when it is combined with Simvastatin.Approved
NilotinibThe metabolism of Simvastatin can be decreased when combined with Nilotinib.Approved, Investigational
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Simvastatin.Approved
NitroaspirinThe serum concentration of Simvastatin can be increased when it is combined with Nitroaspirin.Investigational
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Simvastatin.Approved
OlanzapineThe serum concentration of Olanzapine can be increased when it is combined with Simvastatin.Approved, Investigational
OlaparibThe metabolism of Simvastatin can be decreased when combined with Olaparib.Approved
OmapatrilatThe serum concentration of Simvastatin can be increased when it is combined with Omapatrilat.Investigational
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Simvastatin.Approved
OsimertinibThe serum concentration of Simvastatin can be increased when it is combined with Osimertinib.Approved
OtamixabanThe serum concentration of Simvastatin can be increased when it is combined with Otamixaban.Investigational
PaclitaxelThe serum concentration of Paclitaxel can be increased when it is combined with Simvastatin.Approved, Vet Approved
PalbociclibThe serum concentration of Simvastatin can be increased when it is combined with Palbociclib.Approved
PanobinostatThe serum concentration of Simvastatin can be increased when it is combined with Panobinostat.Approved, Investigational
ParoxetineThe metabolism of Simvastatin can be decreased when combined with Paroxetine.Approved, Investigational
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Simvastatin.Approved
Peginterferon alfa-2bThe serum concentration of Simvastatin can be decreased when it is combined with Peginterferon alfa-2b.Approved
PentobarbitalThe metabolism of Simvastatin can be increased when combined with Pentobarbital.Approved, Vet Approved
PerindoprilThe serum concentration of Simvastatin can be increased when it is combined with Perindopril.Approved
PhenindioneSimvastatin may increase the anticoagulant activities of Phenindione.Approved
PhenobarbitalThe metabolism of Simvastatin can be increased when combined with Phenobarbital.Approved
PhenprocoumonSimvastatin may increase the anticoagulant activities of Phenprocoumon.Approved
PhenytoinThe serum concentration of Simvastatin can be decreased when it is combined with Phenytoin.Approved, Vet Approved
PhosphoramidonThe serum concentration of Simvastatin can be increased when it is combined with Phosphoramidon.Experimental
PioglitazoneThe metabolism of Simvastatin can be decreased when combined with Pioglitazone.Approved, Investigational
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Simvastatin.Approved
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Simvastatin.Approved
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Simvastatin.Approved
PosaconazoleThe serum concentration of Simvastatin can be increased when it is combined with Posaconazole.Approved, Investigational, Vet Approved
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Simvastatin.Approved
PrazosinThe serum concentration of Prazosin can be increased when it is combined with Simvastatin.Approved
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Simvastatin.Approved, Vet Approved
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Simvastatin.Approved, Vet Approved
PrimidoneThe metabolism of Simvastatin can be increased when combined with Primidone.Approved, Vet Approved
PrinomastatThe serum concentration of Simvastatin can be increased when it is combined with Prinomastat.Investigational
ProgesteroneThe serum concentration of Progesterone can be increased when it is combined with Simvastatin.Approved, Vet Approved
PromazineThe metabolism of Simvastatin can be decreased when combined with Promazine.Approved, Vet Approved
PropranololThe serum concentration of Propranolol can be increased when it is combined with Simvastatin.Approved, Investigational
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Simvastatin.Approved
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Simvastatin.Approved
QuinaprilThe serum concentration of Simvastatin can be increased when it is combined with Quinapril.Approved, Investigational
QuinidineThe metabolism of Simvastatin can be decreased when combined with Quinidine.Approved
QuinineThe serum concentration of Simvastatin can be increased when it is combined with Quinine.Approved
RabeprazoleThe metabolism of Simvastatin can be decreased when combined with Rabeprazole.Approved, Investigational
RacecadotrilThe serum concentration of Simvastatin can be increased when it is combined with Racecadotril.Investigational
RaltegravirRaltegravir may increase the myopathic rhabdomyolysis activities of Simvastatin.Approved
RamiprilThe serum concentration of Simvastatin can be increased when it is combined with Ramipril.Approved
RanitidineThe serum concentration of Ranitidine can be increased when it is combined with Simvastatin.Approved
RanolazineThe serum concentration of Simvastatin can be increased when it is combined with Ranolazine.Approved, Investigational
RemikirenThe serum concentration of Simvastatin can be increased when it is combined with Remikiren.Approved
ReserpineThe serum concentration of Reserpine can be increased when it is combined with Simvastatin.Approved
RifabutinThe metabolism of Simvastatin can be increased when combined with Rifabutin.Approved
RifampicinThe metabolism of Simvastatin can be increased when combined with Rifampicin.Approved
RifapentineThe metabolism of Simvastatin can be increased when combined with Rifapentine.Approved
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Simvastatin.Approved, Investigational
RisperidoneThe serum concentration of Risperidone can be increased when it is combined with Simvastatin.Approved, Investigational
RitonavirThe serum concentration of Simvastatin can be increased when it is combined with Ritonavir.Approved, Investigational
RivaroxabanThe serum concentration of Simvastatin can be increased when it is combined with Rivaroxaban.Approved
RolapitantThe metabolism of Simvastatin can be decreased when combined with Rolapitant.Approved
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Simvastatin.Approved, Investigational
RopiniroleThe metabolism of Simvastatin can be decreased when combined with Ropinirole.Approved, Investigational
RosiglitazoneThe metabolism of Simvastatin can be decreased when combined with Rosiglitazone.Approved, Investigational
Salicylic acidThe serum concentration of Salicylic acid can be increased when it is combined with Simvastatin.Approved, Vet Approved
SaquinavirThe serum concentration of Simvastatin can be increased when it is combined with Saquinavir.Approved, Investigational
SaxagliptinThe serum concentration of Simvastatin can be increased when it is combined with Saxagliptin.Approved
SecobarbitalThe metabolism of Simvastatin can be increased when combined with Secobarbital.Approved, Vet Approved
SelexipagThe serum concentration of Selexipag can be increased when it is combined with Simvastatin.Approved
SertralineThe metabolism of Simvastatin can be decreased when combined with Sertraline.Approved
SildenafilThe metabolism of Simvastatin can be decreased when combined with Sildenafil.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Simvastatin.Approved
SiltuximabThe serum concentration of Simvastatin can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Simvastatin can be increased when it is combined with Simeprevir.Approved
SitagliptinThe serum concentration of Simvastatin can be increased when it is combined with Sitagliptin.Approved, Investigational
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Simvastatin.Approved
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Simvastatin.Approved, Investigational
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Simvastatin.Approved
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Simvastatin.Experimental
SpiraprilThe serum concentration of Simvastatin can be increased when it is combined with Spirapril.Approved
St. John's WortThe metabolism of Simvastatin can be increased when combined with St. John's Wort.Nutraceutical
StiripentolThe serum concentration of Simvastatin can be increased when it is combined with Stiripentol.Approved
SulfamethoxazoleThe metabolism of Simvastatin can be decreased when combined with Sulfamethoxazole.Approved
SulfisoxazoleThe metabolism of Simvastatin can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
TacrolimusThe serum concentration of Tacrolimus can be increased when it is combined with Simvastatin.Approved, Investigational
TamoxifenThe serum concentration of Tamoxifen can be increased when it is combined with Simvastatin.Approved
Taurocholic AcidThe serum concentration of Taurocholic Acid can be increased when it is combined with Simvastatin.Experimental
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Simvastatin.Approved
TelaprevirThe serum concentration of Simvastatin can be increased when it is combined with Telaprevir.Approved
TelithromycinThe serum concentration of Simvastatin can be increased when it is combined with Telithromycin.Approved
TemocaprilThe serum concentration of Simvastatin can be increased when it is combined with Temocapril.Experimental, Investigational
TemsirolimusThe serum concentration of Temsirolimus can be increased when it is combined with Simvastatin.Approved
TerbinafineThe metabolism of Simvastatin can be decreased when combined with Terbinafine.Approved, Investigational, Vet Approved
TeriflunomideThe serum concentration of Simvastatin can be increased when it is combined with Teriflunomide.Approved
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Simvastatin.Approved
ThiorphanThe serum concentration of Simvastatin can be increased when it is combined with Thiorphan.Experimental
TicagrelorThe serum concentration of Simvastatin can be increased when it is combined with Ticagrelor.Approved
TiclopidineThe metabolism of Simvastatin can be decreased when combined with Ticlopidine.Approved
TimololThe serum concentration of Timolol can be increased when it is combined with Simvastatin.Approved
TipranavirThe serum concentration of Simvastatin can be increased when it is combined with Tipranavir.Approved, Investigational
TocilizumabThe serum concentration of Simvastatin can be decreased when it is combined with Tocilizumab.Approved
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Simvastatin.Approved
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Simvastatin.Approved, Investigational
ToremifeneThe serum concentration of Toremifene can be increased when it is combined with Simvastatin.Approved, Investigational
TrabectedinSimvastatin may increase the myopathic rhabdomyolysis activities of Trabectedin.Approved, Investigational
TrandolaprilThe serum concentration of Simvastatin can be increased when it is combined with Trandolapril.Approved
TranylcypromineThe metabolism of Simvastatin can be decreased when combined with Tranylcypromine.Approved
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with Simvastatin.Approved
TrimethoprimThe metabolism of Simvastatin can be decreased when combined with Trimethoprim.Approved, Vet Approved
UbenimexThe serum concentration of Simvastatin can be increased when it is combined with Ubenimex.Experimental
UlinastatinThe serum concentration of Simvastatin can be increased when it is combined with Ulinastatin.Investigational
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Simvastatin.Approved
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Simvastatin.Approved
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Simvastatin.Approved
VenetoclaxThe serum concentration of Venetoclax can be increased when it is combined with Simvastatin.Approved
VenlafaxineThe metabolism of Simvastatin can be decreased when combined with Venlafaxine.Approved
VerapamilThe serum concentration of Simvastatin can be increased when it is combined with Verapamil.Approved
VildagliptinThe serum concentration of Simvastatin can be increased when it is combined with Vildagliptin.Approved, Investigational
VinblastineThe serum concentration of Vinblastine can be increased when it is combined with Simvastatin.Approved
VincristineThe serum concentration of Vincristine can be increased when it is combined with Simvastatin.Approved, Investigational
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Simvastatin.Approved
VoriconazoleThe serum concentration of Simvastatin can be increased when it is combined with Voriconazole.Approved, Investigational
WarfarinSimvastatin may increase the anticoagulant activities of Warfarin.Approved
XimelagatranThe serum concentration of Simvastatin can be increased when it is combined with Ximelagatran.Approved, Investigational, Withdrawn
Ym150The serum concentration of Simvastatin can be increased when it is combined with Ym150.Investigational
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Simvastatin.Approved
ZiprasidoneThe metabolism of Simvastatin can be decreased when combined with Ziprasidone.Approved
Food Interactions
  • Avoid alcohol.
  • Avoid drastic changes in dietary habit.
  • Avoid taking with grapefruit juice.
References
Synthesis Reference

Shieh-Shung J. Chen, Byron H. Arison, “Process for the preparation of 3-keto, 5-hydroxy simvastatin analogs.” U.S. Patent US4965200, issued April, 1981.

US4965200
General References
  1. Wolozin B, Wang SW, Li NC, Lee A, Lee TA, Kazis LE: Simvastatin is associated with a reduced incidence of dementia and Parkinson's disease. BMC Med. 2007 Jul 19;5:20. [PubMed:17640385 ]
External Links
ATC CodesC10BX04C10BA02C10BA04A10BH51C10AA01C10BX01
AHFS Codes
  • 24:06.08
PDB EntriesNot Available
FDA labelDownload (102 KB)
MSDSDownload (87.5 KB)
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9475
Blood Brain Barrier+0.9422
Caco-2 permeable-0.5951
P-glycoprotein substrateSubstrate0.8508
P-glycoprotein inhibitor IInhibitor0.7335
P-glycoprotein inhibitor IIInhibitor0.8387
Renal organic cation transporterNon-inhibitor0.8435
CYP450 2C9 substrateNon-substrate0.835
CYP450 2D6 substrateNon-substrate0.9254
CYP450 3A4 substrateSubstrate0.7513
CYP450 1A2 substrateNon-inhibitor0.9045
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorNon-inhibitor0.9307
CYP450 2C19 inhibitorNon-inhibitor0.9025
CYP450 3A4 inhibitorInhibitor0.7959
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8682
Ames testNon AMES toxic0.792
CarcinogenicityNon-carcinogens0.9408
BiodegradationNot ready biodegradable0.9657
Rat acute toxicity2.0061 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8921
hERG inhibition (predictor II)Non-inhibitor0.8573
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Synthon pharmaceuticals ltd
  • Accord healthcare inc
  • Aurobindo pharma ltd
  • Dr reddys laboratories inc
  • Dr reddys laboratories ltd
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Lupin ltd
  • Matrix laboratories ltd
  • Perrigo r and d co
  • Ranbaxy laboratories ltd
  • Sandoz inc
  • Watson laboratories inc
  • Zydus pharmaceuticals usa inc
  • Merck research laboratories div merck co inc
Packagers
Dosage forms
FormRouteStrength
TabletOral5 mg
TabletOral80 mg
Tablet, film coated, extended releaseOral
TabletOral10 mg/1
TabletOral20 mg/1
TabletOral40 mg/1
TabletOral5 mg/1
TabletOral80 mg/1
TabletOral
TabletOral10 mg
TabletOral20 mg
TabletOral40 mg
Tablet, film coatedOral10 mg/1
Tablet, film coatedOral20 mg/1
Tablet, film coatedOral40 mg/1
Tablet, film coatedOral5 mg/1
Tablet, film coatedOral80 mg/1
Prices
Unit descriptionCostUnit
Zocor 90 40 mg tablet Bottle525.16USD bottle
Simvastatin 100% powder10.71USD g
Vytorin 10-20 mg tablet5.05USD tablet
Vytorin 10-40 mg tablet5.05USD tablet
Vytorin 10-10 mg tablet4.97USD tablet
Zocor 20 mg tablet4.69USD tablet
Zocor 80 mg tablet4.69USD tablet
Vytorin 10-80 mg tablet4.63USD tablet
Zocor 40 mg tablet4.11USD tablet
Simvastatin 20 mg tablet3.83USD tablet
Simvastatin 40 mg tablet3.83USD tablet
Simvastatin 80 mg tablet3.83USD tablet
Zocor 10 mg tablet2.89USD tablet
Simvastatin 10 mg tablet2.31USD tablet
Zocor 5 mg tablet1.99USD tablet
Simvastatin 5 mg tablet1.63USD tablet
Phl-Simvastatin 40 mg Tablet1.45USD tablet
Phl-Simvastatin 80 mg Tablet1.45USD tablet
Pms-Simvastatin 20 mg Tablet1.45USD tablet
Pms-Simvastatin 40 mg Tablet1.45USD tablet
Pms-Simvastatin 80 mg Tablet1.45USD tablet
Ran-Simvastatin 20 mg Tablet1.45USD tablet
Ran-Simvastatin 40 mg Tablet1.45USD tablet
Ran-Simvastatin 80 mg Tablet1.45USD tablet
Ratio-Simvastatin 20 mg Tablet1.45USD tablet
Ratio-Simvastatin 40 mg Tablet1.45USD tablet
Ratio-Simvastatin 80 mg Tablet1.45USD tablet
Sandoz Simvastatin 20 mg Tablet1.45USD tablet
Sandoz Simvastatin 40 mg Tablet1.45USD tablet
Sandoz Simvastatin 80 mg Tablet1.45USD tablet
Apo-Simvastatin 20 mg Tablet1.45USD tablet
Apo-Simvastatin 40 mg Tablet1.45USD tablet
Apo-Simvastatin 80 mg Tablet1.45USD tablet
Co Simvastatin 20 mg Tablet1.45USD tablet
Co Simvastatin 40 mg Tablet1.45USD tablet
Co Simvastatin 80 mg Tablet1.45USD tablet
Jamp-Simvastatin 20 mg Tablet1.45USD tablet
Jamp-Simvastatin 40 mg Tablet1.45USD tablet
Jamp-Simvastatin 80 mg Tablet1.45USD tablet
Mylan-Simvastatin 20 mg Tablet1.45USD tablet
Mylan-Simvastatin 40 mg Tablet1.45USD tablet
Mylan-Simvastatin 80 mg Tablet1.45USD tablet
Novo-Simvastatin 20 mg Tablet1.45USD tablet
Novo-Simvastatin 40 mg Tablet1.45USD tablet
Novo-Simvastatin 80 mg Tablet1.45USD tablet
Phl-Simvastatin 20 mg Tablet1.45USD tablet
Apo-Simvastatin 10 mg Tablet1.17USD tablet
Co Simvastatin 10 mg Tablet1.17USD tablet
Jamp-Simvastatin 10 mg Tablet1.17USD tablet
Mylan-Simvastatin 10 mg Tablet1.17USD tablet
Novo-Simvastatin 10 mg Tablet1.17USD tablet
Phl-Simvastatin 10 mg Tablet1.17USD tablet
Pms-Simvastatin 10 mg Tablet1.17USD tablet
Ran-Simvastatin 10 mg Tablet1.17USD tablet
Ratio-Simvastatin 10 mg Tablet1.17USD tablet
Sandoz Simvastatin 10 mg Tablet1.17USD tablet
Apo-Simvastatin 5 mg Tablet0.59USD tablet
Co Simvastatin 5 mg Tablet0.59USD tablet
Jamp-Simvastatin 5 mg Tablet0.59USD tablet
Mylan-Simvastatin 5 mg Tablet0.59USD tablet
Novo-Simvastatin 5 mg Tablet0.59USD tablet
Phl-Simvastatin 5 mg Tablet0.59USD tablet
Pms-Simvastatin 5 mg Tablet0.59USD tablet
Ran-Simvastatin 5 mg Tablet0.59USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US5846966 No1993-09-212013-09-21Us
US6080428 No1997-05-272017-05-27Us
US6303661 No1997-04-242017-04-24Us
US6469035 No1998-03-152018-03-15Us
US6699871 No2002-07-262022-07-26Us
US6890898 No1999-02-022019-02-02Us
US7078381 No1999-02-022019-02-02Us
US7125873 No2002-07-262022-07-26Us
US7326708 No2006-04-112026-04-11Us
US7459428 No1999-02-022019-02-02Us
US8168637 No2002-06-262022-06-26Us
USRE37721 Yes1997-04-252017-04-25Us
USRE42461 Yes1997-04-252017-04-25Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point135-138 °CPhysProp
water solubilityInsoluble FDA label
logP4.68HANSCH,C ET AL. (1995)
Predicted Properties
PropertyValueSource
Water Solubility0.0122 mg/mLALOGPS
logP4.51ALOGPS
logP4.46ChemAxon
logS-4.5ALOGPS
pKa (Strongest Acidic)14.91ChemAxon
pKa (Strongest Basic)-2.8ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area72.83 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity117.68 m3·mol-1ChemAxon
Polarizability47.85 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
MSMass Spectrum (Electron Ionization)splash10-0a4i-3900000000-d04758924bf88a90c017View in MoNA
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as delta valerolactones. These are cyclic organic compounds containing an oxan-2- one moiety.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassLactones
Sub ClassDelta valerolactones
Direct ParentDelta valerolactones
Alternative Parents
Substituents
  • Delta_valerolactone
  • Fatty acid ester
  • Delta valerolactone
  • Fatty acyl
  • Oxane
  • Dicarboxylic acid or derivatives
  • Saccharide
  • Secondary alcohol
  • Carboxylic acid ester
  • Oxacycle
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organooxygen compound
  • Carbonyl group
  • Alcohol
  • Aliphatic heteropolycyclic compound
Molecular FrameworkAliphatic heteropolycyclic compounds
External Descriptors

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Nadph binding
Specific Function:
Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.
Gene Name:
HMGCR
Uniprot ID:
P04035
Molecular Weight:
97475.155 Da
References
  1. Cenedella RJ, Kuszak JR, Al-Ghoul KJ, Qin S, Sexton PS: Discordant expression of the sterol pathway in lens underlies simvastatin-induced cataracts in Chbb: Thom rats. J Lipid Res. 2003 Jan;44(1):198-211. [PubMed:12518039 ]
  2. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  3. Kocarek TA, Dahn MS, Cai H, Strom SC, Mercer-Haines NA: Regulation of CYP2B6 and CYP3A expression by hydroxymethylglutaryl coenzyme A inhibitors in primary cultured human hepatocytes. Drug Metab Dispos. 2002 Dec;30(12):1400-5. [PubMed:12433810 ]
  4. Liu L, Zhang R, Zhao JJ, Rogers JD, Hsieh JY, Fang W, Matuszewski BK, Dobrinska MR: Determination of simvastatin-derived HMG-CoA reductase inhibitors in biomatrices using an automated enzyme inhibition assay with radioactivity detection. J Pharm Biomed Anal. 2003 Apr 24;32(1):107-23. [PubMed:12852453 ]
  5. Pappu AS, Bacon SP, Illingworth DR: Residual effects of lovastatin and simvastatin on urinary mevalonate excretions in patients with familial hypercholesterolemia. J Lab Clin Med. 2003 Apr;141(4):250-6. [PubMed:12677170 ]
  6. Stoebner PE, Michot C, Ligeron C, Durand L, Meynadier J, Meunier L: [Simvastatin-induced lichen planus pemphigoides]. Ann Dermatol Venereol. 2003 Feb;130(2 Pt 1):187-90. [PubMed:12671581 ]
Kind
Protein
Organism
Human
Pharmacological action
no
Actions
other
General Function:
Protein kinase binding
Specific Function:
Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is a...
Gene Name:
ITGB2
Uniprot ID:
P05107
Molecular Weight:
84781.08 Da
References
  1. Fujii T, Masuyama K, Kawashima K: Simvastatin regulates non-neuronal cholinergic activity in T lymphocytes via CD11a-mediated pathways. J Neuroimmunol. 2006 Oct;179(1-2):101-7. Epub 2006 Jul 10. [PubMed:16828882 ]
  2. Fujii T, Takada-Takatori Y, Kawashima K: Roles played by lymphocyte function-associated antigen-1 in the regulation of lymphocytic cholinergic activity. Life Sci. 2007 May 30;80(24-25):2320-4. Epub 2007 Jan 17. [PubMed:17289088 ]
  3. Katano H, Pesnicak L, Cohen JI: Simvastatin induces apoptosis of Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines and delays development of EBV lymphomas. Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):4960-5. Epub 2004 Mar 23. [PubMed:15041742 ]
  4. Takahashi HK, Mori S, Iwagaki H, Yoshino T, Tanaka N, Nishibori M: Simvastatin induces interleukin-18 production in human peripheral blood mononuclear cells. Clin Immunol. 2005 Sep;116(3):211-6. [PubMed:15936988 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitorinducer
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Neuvonen PJ, Niemi M, Backman JT: Drug interactions with lipid-lowering drugs: mechanisms and clinical relevance. Clin Pharmacol Ther. 2006 Dec;80(6):565-81. [PubMed:17178259 ]
  2. Cohen LH, van Leeuwen RE, van Thiel GC, van Pelt JF, Yap SH: Equally potent inhibitors of cholesterol synthesis in human hepatocytes have distinguishable effects on different cytochrome P450 enzymes. Biopharm Drug Dispos. 2000 Dec;21(9):353-64. [PubMed:11523064 ]
  3. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  4. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  5. Galetin A, Clarke SE, Houston JB: Quinidine and haloperidol as modifiers of CYP3A4 activity: multisite kinetic model approach. Drug Metab Dispos. 2002 Dec;30(12):1512-22. [PubMed:12433827 ]
  6. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
  7. Website [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A5
Uniprot ID:
P20815
Molecular Weight:
57108.065 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A7
Uniprot ID:
P24462
Molecular Weight:
57525.03 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme...
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular Weight:
55824.275 Da
References
  1. Neuvonen PJ, Niemi M, Backman JT: Drug interactions with lipid-lowering drugs: mechanisms and clinical relevance. Clin Pharmacol Ther. 2006 Dec;80(6):565-81. [PubMed:17178259 ]
  2. Tornio A, Pasanen MK, Laitila J, Neuvonen PJ, Backman JT: Comparison of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) as inhibitors of cytochrome P450 2C8. Basic Clin Pharmacol Toxicol. 2005 Aug;97(2):104-8. [PubMed:15998357 ]
  3. Walsky RL, Gaman EA, Obach RS: Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol. 2005 Jan;45(1):68-78. [PubMed:15601807 ]
  4. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitorinducer
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Cohen LH, van Leeuwen RE, van Thiel GC, van Pelt JF, Yap SH: Equally potent inhibitors of cholesterol synthesis in human hepatocytes have distinguishable effects on different cytochrome P450 enzymes. Biopharm Drug Dispos. 2000 Dec;21(9):353-64. [PubMed:11523064 ]
  2. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  3. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Cohen LH, van Leeuwen RE, van Thiel GC, van Pelt JF, Yap SH: Equally potent inhibitors of cholesterol synthesis in human hepatocytes have distinguishable effects on different cytochrome P450 enzymes. Biopharm Drug Dispos. 2000 Dec;21(9):353-64. [PubMed:11523064 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Gene Name:
CYP2B6
Uniprot ID:
P20813
Molecular Weight:
56277.81 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid binding
Specific Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4-methylumbelliferone, 1-naph...
Gene Name:
UGT1A1
Uniprot ID:
P22309
Molecular Weight:
59590.91 Da
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Retinoic acid binding
Specific Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.
Gene Name:
UGT1A3
Uniprot ID:
P35503
Molecular Weight:
60337.835 Da
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Glucuronosyltransferase activity
Specific Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.Its unique specificity for 3,4-catechol estrogens and estriol suggests it may play an important role in regulating the level and activity of these potent and active estrogen metabolites. Is also active with androsterone, hyodeoxycholic acid and tetrachlorocatechol...
Gene Name:
UGT2B7
Uniprot ID:
P16662
Molecular Weight:
60694.12 Da

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Wang E, Casciano CN, Clement RP, Johnson WW: HMG-CoA reductase inhibitors (statins) characterized as direct inhibitors of P-glycoprotein. Pharm Res. 2001 Jun;18(6):800-6. [PubMed:11474784 ]
  2. Wang EJ, Casciano CN, Clement RP, Johnson WW: Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors. Biochem Biophys Res Commun. 2001 Nov 30;289(2):580-5. [PubMed:11716514 ]
  3. Hochman JH, Pudvah N, Qiu J, Yamazaki M, Tang C, Lin JH, Prueksaritanont T: Interactions of human P-glycoprotein with simvastatin, simvastatin acid, and atorvastatin. Pharm Res. 2004 Sep;21(9):1686-91. [PubMed:15497697 ]
  4. Sieczkowski E, Lehner C, Ambros PF, Hohenegger M: Double impact on p-glycoprotein by statins enhances doxorubicin cytotoxicity in human neuroblastoma cells. Int J Cancer. 2010 May 1;126(9):2025-35. doi: 10.1002/ijc.24885. [PubMed:19739078 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin.
Gene Name:
SLCO1A2
Uniprot ID:
P46721
Molecular Weight:
74144.105 Da
References
  1. Hsiang B, Zhu Y, Wang Z, Wu Y, Sasseville V, Yang WP, Kirchgessner TG: A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters. J Biol Chem. 1999 Dec 24;274(52):37161-8. [PubMed:10601278 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver.
Gene Name:
SLCO1B1
Uniprot ID:
Q9Y6L6
Molecular Weight:
76447.99 Da
References
  1. Hsiang B, Zhu Y, Wang Z, Wu Y, Sasseville V, Yang WP, Kirchgessner TG: A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters. J Biol Chem. 1999 Dec 24;274(52):37161-8. [PubMed:10601278 ]
  2. Kameyama Y, Yamashita K, Kobayashi K, Hosokawa M, Chiba K: Functional characterization of SLCO1B1 (OATP-C) variants, SLCO1B1*5, SLCO1B1*15 and SLCO1B1*15+C1007G, by using transient expression systems of HeLa and HEK293 cells. Pharmacogenet Genomics. 2005 Jul;15(7):513-22. [PubMed:15970799 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Organic anion transmembrane transporter activity
Specific Function:
Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.
Gene Name:
ABCC2
Uniprot ID:
Q92887
Molecular Weight:
174205.64 Da
References
  1. Becker ML, Elens LL, Visser LE, Hofman A, Uitterlinden AG, van Schaik RH, Stricker BH: Genetic variation in the ABCC2 gene is associated with dose decreases or switches to other cholesterol-lowering drugs during simvastatin and atorvastatin therapy. Pharmacogenomics J. 2013 Jun;13(3):251-6. doi: 10.1038/tpj.2011.59. Epub 2011 Dec 20. [PubMed:22186618 ]
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Drug created on June 13, 2005 07:24 / Updated on December 09, 2016 03:54