Simvastatin - DrugBank

ID Pharmacology Interactions References Trials Economics Properties Spectra Taxonomy

Targets (3)Enzymes (11)Transporters (4)

Targets (3)Enzymes (11)Transporters (4)Biointeractions (23)

Identification

Name

Simvastatin

Accession Number

DB00641 (APRD00104)

Type

Small Molecule

Groups

Approved

Description

Simvastatin is a lipid-lowering agent that is derived synthetically from the fermentation of Aspergillus terreus. It is a potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (hydroxymethylglutaryl COA reductases), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL receptors, it increases breakdown of LDL cholesterol. [PubChem]

Structure

MOL SDF 3D-SDF PDB SMILES InChI View 3D Structure

Synonyms

2,2-Dimethylbutyric acid, 8-ester with (4R,6R)-6-(2-((1S,2S,6R,8S,8ar)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthyl)ethyl)tetrahydro-4-hydroxy-2H-pyran-2-one

Simvastatin

Simvastatina

Simvastatine

Simvastatinum

Synvinolin

Zocor

External IDs

C10AA01 / MK 733 / MK-0733 / MK-733

Product Ingredients

Ingredient	UNII	CAS	InChI Key	Details
Acetyl simvastatin	171OXS3HEK	145576-25-6	OHVWRJDVJRNCPE-BIKFJBPRSA-N	Details
Tenivastatin sodium	2L6JSY5YGL	101314-97-0	RLWRROYWKHUVKF-OKDJMAGBSA-M	Details

Product Images

Approved Prescription Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
Act Simvastatin	Tablet	80 mg	Oral	Actavis Pharma Company	2003-09-26	Not applicable	Canada
Act Simvastatin	Tablet	20 mg	Oral	Actavis Pharma Company	2003-09-26	Not applicable	Canada
Act Simvastatin	Tablet	5 mg	Oral	Actavis Pharma Company	2003-09-26	Not applicable	Canada
Act Simvastatin	Tablet	40 mg	Oral	Actavis Pharma Company	2003-09-26	Not applicable	Canada
Act Simvastatin	Tablet	10 mg	Oral	Actavis Pharma Company	2003-09-26	Not applicable	Canada
Auro-simvastatin	Tablet	80 mg	Oral	Auro Pharma Inc	2013-07-08	Not applicable	Canada
Auro-simvastatin	Tablet	10 mg	Oral	Auro Pharma Inc	2013-07-08	Not applicable	Canada
Auro-simvastatin	Tablet	5 mg	Oral	Auro Pharma Inc	2013-07-08	Not applicable	Canada
Auro-simvastatin	Tablet	20 mg	Oral	Auro Pharma Inc	2013-07-08	Not applicable	Canada
Auro-simvastatin	Tablet	40 mg	Oral	Auro Pharma Inc	2013-07-08	Not applicable	Canada
Ava-simvastatin	Tablet	20 mg	Oral	Avanstra Inc	2011-10-11	2014-08-21	Canada
Ava-simvastatin	Tablet	10 mg	Oral	Avanstra Inc	2011-10-11	2014-08-21	Canada
Ava-simvastatin	Tablet	40 mg	Oral	Avanstra Inc	2011-10-11	2014-08-21	Canada
Ava-simvastatin	Tablet	80 mg	Oral	Avanstra Inc	2011-10-11	2014-08-21	Canada
Ava-simvastatin	Tablet	5 mg	Oral	Avanstra Inc	2011-10-11	2014-08-21	Canada
Bci Simvastatin	Tablet	5 mg	Oral	Baker Cummins Inc	Not applicable	Not applicable	Canada
Bci Simvastatin	Tablet	80 mg	Oral	Baker Cummins Inc	Not applicable	Not applicable	Canada
Bci Simvastatin	Tablet	40 mg	Oral	Baker Cummins Inc	Not applicable	Not applicable	Canada
Bci Simvastatin	Tablet	10 mg	Oral	Baker Cummins Inc	Not applicable	Not applicable	Canada
Bci Simvastatin	Tablet	20 mg	Oral	Baker Cummins Inc	Not applicable	Not applicable	Canada
Dom-simvastatin	Tablet	5 mg	Oral	Dominion Pharmacal	2004-08-11	Not applicable	Canada
Dom-simvastatin	Tablet	40 mg	Oral	Dominion Pharmacal	2004-08-11	Not applicable	Canada
Dom-simvastatin	Tablet	5 mg	Oral	Dominion Pharmacal	2006-08-02	Not applicable	Canada
Dom-simvastatin	Tablet	40 mg	Oral	Dominion Pharmacal	2006-08-02	Not applicable	Canada
Dom-simvastatin	Tablet	10 mg	Oral	Dominion Pharmacal	2004-08-11	Not applicable	Canada
Dom-simvastatin	Tablet	80 mg	Oral	Dominion Pharmacal	2004-08-11	Not applicable	Canada
Dom-simvastatin	Tablet	10 mg	Oral	Dominion Pharmacal	2006-08-02	Not applicable	Canada
Dom-simvastatin	Tablet	80 mg	Oral	Dominion Pharmacal	2006-08-02	Not applicable	Canada
Dom-simvastatin	Tablet	20 mg	Oral	Dominion Pharmacal	2004-08-11	Not applicable	Canada
Dom-simvastatin	Tablet	20 mg	Oral	Dominion Pharmacal	2006-08-02	Not applicable	Canada
Ipg-simvastatin	Tablet	10 mg	Oral	Marcan Pharmaceuticals Inc	Not applicable	Not applicable	Canada
Ipg-simvastatin	Tablet	80 mg	Oral	Marcan Pharmaceuticals Inc	Not applicable	Not applicable	Canada
Ipg-simvastatin	Tablet	20 mg	Oral	Marcan Pharmaceuticals Inc	Not applicable	Not applicable	Canada
Ipg-simvastatin	Tablet	5 mg	Oral	Marcan Pharmaceuticals Inc	Not applicable	Not applicable	Canada
Ipg-simvastatin	Tablet	40 mg	Oral	Marcan Pharmaceuticals Inc	Not applicable	Not applicable	Canada
Jamp-simvastatin	Tablet	5 mg	Oral	Jamp Pharma Corporation	2012-01-09	Not applicable	Canada
Jamp-simvastatin	Tablet	40 mg	Oral	Jamp Pharma Corporation	2010-03-12	2013-07-08	Canada
Jamp-simvastatin	Tablet	80 mg	Oral	Jamp Pharma Corporation	2012-01-09	Not applicable	Canada
Jamp-simvastatin	Tablet	20 mg	Oral	Jamp Pharma Corporation	2010-03-12	2013-07-08	Canada
Jamp-simvastatin	Tablet	40 mg	Oral	Jamp Pharma Corporation	2012-01-09	Not applicable	Canada
Jamp-simvastatin	Tablet	5 mg	Oral	Jamp Pharma Corporation	2010-03-23	2013-07-08	Canada
Jamp-simvastatin	Tablet	10 mg	Oral	Jamp Pharma Corporation	2012-01-09	Not applicable	Canada
Jamp-simvastatin	Tablet	80 mg	Oral	Jamp Pharma Corporation	2010-03-12	2013-07-08	Canada
Jamp-simvastatin	Tablet	10 mg	Oral	Jamp Pharma Corporation	2010-03-12	2013-07-08	Canada
Jamp-simvastatin	Tablet	20 mg	Oral	Jamp Pharma Corporation	2012-01-09	Not applicable	Canada
Mar-simvastatin	Tablet	20 mg	Oral	Marcan Pharmaceuticals Inc	2012-12-20	Not applicable	Canada
Mar-simvastatin	Tablet	5 mg	Oral	Marcan Pharmaceuticals Inc	2012-12-20	Not applicable	Canada
Mar-simvastatin	Tablet	40 mg	Oral	Marcan Pharmaceuticals Inc	2012-12-20	Not applicable	Canada
Mar-simvastatin	Tablet	10 mg	Oral	Marcan Pharmaceuticals Inc	2012-12-20	Not applicable	Canada
Mar-simvastatin	Tablet	80 mg	Oral	Marcan Pharmaceuticals Inc	2012-12-20	Not applicable	Canada
Mint-simvastatin	Tablet	20 mg	Oral	Mint Pharmaceuticals Inc	2011-09-07	Not applicable	Canada
Mint-simvastatin	Tablet	5 mg	Oral	Mint Pharmaceuticals Inc	2011-09-07	Not applicable	Canada
Mint-simvastatin	Tablet	40 mg	Oral	Mint Pharmaceuticals Inc	2011-09-07	Not applicable	Canada
Mint-simvastatin	Tablet	10 mg	Oral	Mint Pharmaceuticals Inc	2011-09-07	Not applicable	Canada
Mint-simvastatin	Tablet	80 mg	Oral	Mint Pharmaceuticals Inc	2011-09-07	Not applicable	Canada
Mylan-simvastatin	Tablet	80 mg	Oral	Mylan Pharmaceuticals	2003-01-15	Not applicable	Canada
Mylan-simvastatin	Tablet	40 mg	Oral	Mylan Pharmaceuticals	2003-01-15	Not applicable	Canada
Mylan-simvastatin	Tablet	20 mg	Oral	Mylan Pharmaceuticals	2003-01-15	Not applicable	Canada
Mylan-simvastatin	Tablet	5 mg	Oral	Mylan Pharmaceuticals	2003-01-15	Not applicable	Canada
Mylan-simvastatin	Tablet	10 mg	Oral	Mylan Pharmaceuticals	2003-01-15	Not applicable	Canada
Ntp-simvastatin	Tablet	5 mg	Oral	Nt Pharma Canada Ltd	Not applicable	Not applicable	Canada
Ntp-simvastatin	Tablet	40 mg	Oral	Nt Pharma Canada Ltd	Not applicable	Not applicable	Canada
Ntp-simvastatin	Tablet	10 mg	Oral	Nt Pharma Canada Ltd	Not applicable	Not applicable	Canada
Ntp-simvastatin	Tablet	80 mg	Oral	Nt Pharma Canada Ltd	Not applicable	Not applicable	Canada
Ntp-simvastatin	Tablet	20 mg	Oral	Nt Pharma Canada Ltd	Not applicable	Not applicable	Canada
Nu-simvastatin Tablets	Tablet	5 mg	Oral	Nu Pharm Inc	2004-06-21	2012-09-04	Canada
Nu-simvastatin Tablets	Tablet	40 mg	Oral	Nu Pharm Inc	2004-06-21	2012-09-04	Canada
Nu-simvastatin Tablets	Tablet	10 mg	Oral	Nu Pharm Inc	2004-06-21	2012-09-04	Canada
Nu-simvastatin Tablets	Tablet	80 mg	Oral	Nu Pharm Inc	2004-06-21	2012-09-04	Canada
Nu-simvastatin Tablets	Tablet	20 mg	Oral	Nu Pharm Inc	2004-06-21	2012-09-04	Canada
PHL-simvastatin	Tablet	20 mg	Oral	Pharmel Inc	2006-07-21	Not applicable	Canada
PHL-simvastatin	Tablet	10 mg	Oral	Pharmel Inc	2004-08-11	Not applicable	Canada
PHL-simvastatin	Tablet	80 mg	Oral	Pharmel Inc	2004-08-11	Not applicable	Canada
PHL-simvastatin	Tablet	10 mg	Oral	Pharmel Inc	2006-07-21	Not applicable	Canada
PHL-simvastatin	Tablet	40 mg	Oral	Pharmel Inc	2006-07-21	Not applicable	Canada
PHL-simvastatin	Tablet	20 mg	Oral	Pharmel Inc	2004-08-11	Not applicable	Canada
PHL-simvastatin	Tablet	5 mg	Oral	Pharmel Inc	2004-08-11	Not applicable	Canada
PHL-simvastatin	Tablet	80 mg	Oral	Pharmel Inc	2006-07-21	Not applicable	Canada
PHL-simvastatin	Tablet	40 mg	Oral	Pharmel Inc	2004-08-11	Not applicable	Canada
PHL-simvastatin	Tablet	5 mg	Oral	Pharmel Inc	2006-07-21	Not applicable	Canada
PMS-simvastatin	Tablet	40 mg	Oral	Pharmascience Inc	2005-11-03	Not applicable	Canada
PMS-simvastatin	Tablet	10 mg	Oral	Pharmascience Inc	2004-05-07	Not applicable	Canada
PMS-simvastatin	Tablet	80 mg	Oral	Pharmascience Inc	2004-05-07	Not applicable	Canada
PMS-simvastatin	Tablet	10 mg	Oral	Pharmascience Inc	2005-11-03	Not applicable	Canada
PMS-simvastatin	Tablet	80 mg	Oral	Pharmascience Inc	2005-11-03	Not applicable	Canada
PMS-simvastatin	Tablet	20 mg	Oral	Pharmascience Inc	2004-05-07	Not applicable	Canada
PMS-simvastatin	Tablet	20 mg	Oral	Pharmascience Inc	2005-11-03	Not applicable	Canada
PMS-simvastatin	Tablet	5 mg	Oral	Pharmascience Inc	2004-05-07	Not applicable	Canada
PMS-simvastatin	Tablet	40 mg	Oral	Pharmascience Inc	2004-05-07	Not applicable	Canada
PMS-simvastatin	Tablet	5 mg	Oral	Pharmascience Inc	2005-11-03	Not applicable	Canada
Q-simvastatin	Tablet	20 mg	Oral	Qd Pharmaceuticals Ulc	2012-02-03	2015-08-21	Canada
Q-simvastatin	Tablet	40 mg	Oral	Qd Pharmaceuticals Ulc	2012-02-03	2015-08-21	Canada
Q-simvastatin	Tablet	5 mg	Oral	Qd Pharmaceuticals Ulc	Not applicable	Not applicable	Canada
Q-simvastatin	Tablet	10 mg	Oral	Qd Pharmaceuticals Ulc	2012-02-03	2015-08-21	Canada
Q-simvastatin	Tablet	80 mg	Oral	Qd Pharmaceuticals Ulc	Not applicable	Not applicable	Canada
Ran-simvastatin	Tablet	5 mg	Oral	Ranbaxy Inc.	2009-07-20	Not applicable	Canada
Ran-simvastatin	Tablet	40 mg	Oral	Ranbaxy Inc.	2009-07-20	Not applicable	Canada
Ran-simvastatin	Tablet	10 mg	Oral	Ranbaxy Inc.	2009-07-20	Not applicable	Canada
Ran-simvastatin	Tablet	80 mg	Oral	Ranbaxy Inc.	2009-07-20	Not applicable	Canada
Ran-simvastatin	Tablet	20 mg	Oral	Ranbaxy Inc.	2009-07-20	Not applicable	Canada
Ratio-simvastatin	Tablet	20 mg	Oral	Ratiopharm Inc Division Of Teva Canada Limited	2003-10-27	2014-09-19	Canada
Ratio-simvastatin	Tablet	10 mg	Oral	Ratiopharm Inc Division Of Teva Canada Limited	2003-10-27	2014-09-19	Canada
Ratio-simvastatin	Tablet	40 mg	Oral	Ratiopharm Inc Division Of Teva Canada Limited	2003-10-27	2014-09-19	Canada
Ratio-simvastatin	Tablet	5 mg	Oral	Ratiopharm Inc Division Of Teva Canada Limited	2003-10-27	2014-09-19	Canada
Ratio-simvastatin	Tablet	80 mg	Oral	Ratiopharm Inc Division Of Teva Canada Limited	2003-10-27	2014-09-19	Canada
Riva-simvastatin	Tablet	20 mg	Oral	Laboratoire Riva Inc	2003-03-10	Not applicable	Canada
Riva-simvastatin	Tablet	5 mg	Oral	Laboratoire Riva Inc	2003-03-10	Not applicable	Canada
Riva-simvastatin	Tablet	40 mg	Oral	Laboratoire Riva Inc	2003-03-10	Not applicable	Canada
Riva-simvastatin	Tablet	10 mg	Oral	Laboratoire Riva Inc	2003-03-10	Not applicable	Canada
Riva-simvastatin	Tablet	80 mg	Oral	Laboratoire Riva Inc	2003-03-10	Not applicable	Canada
Sandoz Simvastatin	Tablet	10 mg	Oral	Sandoz Canada Incorporated	2003-10-29	Not applicable	Canada
Sandoz Simvastatin	Tablet	80 mg	Oral	Sandoz Canada Incorporated	2003-10-29	Not applicable	Canada
Sandoz Simvastatin	Tablet	5 mg	Oral	Sandoz Canada Incorporated	2003-10-29	Not applicable	Canada
Sandoz Simvastatin	Tablet	20 mg	Oral	Sandoz Canada Incorporated	2004-06-23	Not applicable	Canada
Sandoz Simvastatin	Tablet	40 mg	Oral	Sandoz Canada Incorporated	2003-10-29	Not applicable	Canada
Septa-simvastatin	Tablet	10 mg	Oral	Septa Pharmaceuticals Inc	Not applicable	Not applicable	Canada
Septa-simvastatin	Tablet	80 mg	Oral	Septa Pharmaceuticals Inc	Not applicable	Not applicable	Canada
Septa-simvastatin	Tablet	5 mg	Oral	Septa Pharmaceuticals Inc	Not applicable	Not applicable	Canada
Septa-simvastatin	Tablet	20 mg	Oral	Septa Pharmaceuticals Inc	Not applicable	Not applicable	Canada
Septa-simvastatin	Tablet	40 mg	Oral	Septa Pharmaceuticals Inc	Not applicable	Not applicable	Canada
Simvastatin	Tablet	20 mg	Oral	Cobalt Laboratories	Not applicable	Not applicable	Canada
Simvastatin	Tablet	40 mg	Oral	Frosst A Division Of Merck Canada Inc	Not applicable	Not applicable	Canada
Simvastatin	Tablet	80 mg	Oral	Sanis Health Inc	2009-10-22	Not applicable	Canada
Simvastatin	Tablet	10 mg	Oral	Sivem Pharmaceuticals Ulc	2012-06-11	Not applicable	Canada
Simvastatin	Tablet	5 mg	Oral	Sanis Health Inc	2009-10-22	Not applicable	Canada
Simvastatin	Tablet	20 mg	Oral	Bentec Pharma Inc	Not applicable	Not applicable	Canada
Simvastatin	Tablet	40 mg	Oral	Meliapharm Inc	2010-06-11	2014-06-25	Canada
Simvastatin	Tablet	40 mg	Oral	Sanis Health Inc	2009-10-22	Not applicable	Canada
Simvastatin	Tablet	5 mg	Oral	Sivem Pharmaceuticals Ulc	2012-06-11	Not applicable	Canada
Simvastatin	Tablet	5 mg	Oral	Bentec Pharma Inc	Not applicable	Not applicable	Canada
Simvastatin	Tablet	80 mg	Oral	Sivem Pharmaceuticals Ulc	2012-06-11	Not applicable	Canada
Simvastatin	Tablet	10 mg	Oral	Meliapharm Inc	2010-06-11	2014-06-25	Canada
Simvastatin	Tablet	5 mg	Oral	Cobalt Laboratories	Not applicable	Not applicable	Canada
Simvastatin	Tablet	10 mg	Oral	Bentec Pharma Inc	2013-03-01	2015-12-15	Canada
Simvastatin	Tablet	10 mg	Oral	Frosst A Division Of Merck Canada Inc	Not applicable	Not applicable	Canada
Simvastatin	Tablet	40 mg	Oral	Bentec Pharma Inc	Not applicable	Not applicable	Canada
Simvastatin	Tablet	80 mg	Oral	Meliapharm Inc	2010-06-11	2014-06-25	Canada
Simvastatin	Tablet	40 mg	Oral	Cobalt Laboratories	Not applicable	Not applicable	Canada
Simvastatin	Tablet	80 mg	Oral	Frosst A Division Of Merck Canada Inc	Not applicable	Not applicable	Canada
Simvastatin	Tablet	20 mg	Oral	Sivem Pharmaceuticals Ulc	2012-06-12	Not applicable	Canada
Simvastatin	Tablet	10 mg	Oral	Sanis Health Inc	2009-10-22	Not applicable	Canada
Simvastatin	Tablet	20 mg	Oral	Meliapharm Inc	2010-06-11	2014-06-25	Canada
Simvastatin	Tablet	10 mg	Oral	Cobalt Laboratories	Not applicable	Not applicable	Canada
Simvastatin	Tablet	20 mg	Oral	Frosst A Division Of Merck Canada Inc	Not applicable	Not applicable	Canada
Simvastatin	Tablet	20 mg	Oral	Sanis Health Inc	2009-10-22	Not applicable	Canada
Simvastatin	Tablet	80 mg	Oral	Bentec Pharma Inc	Not applicable	Not applicable	Canada
Simvastatin	Tablet	80 mg	Oral	Cobalt Laboratories	Not applicable	Not applicable	Canada
Simvastatin	Tablet	40 mg	Oral	Sivem Pharmaceuticals Ulc	2012-06-11	Not applicable	Canada
Simvastatin	Tablet	5 mg	Oral	Meliapharm Inc	2010-06-11	2014-06-25	Canada
Simvastatin	Tablet	5 mg	Oral	Frosst A Division Of Merck Canada Inc	Not applicable	Not applicable	Canada
Simvastatin Tablets	Tablet	20 mg	Oral	Ranbaxy Inc.	Not applicable	Not applicable	Canada
Simvastatin Tablets	Tablet	5 mg	Oral	Ranbaxy Inc.	Not applicable	Not applicable	Canada
Simvastatin Tablets	Tablet	40 mg	Oral	Ranbaxy Inc.	Not applicable	Not applicable	Canada
Simvastatin Tablets	Tablet	10 mg	Oral	Ranbaxy Inc.	Not applicable	Not applicable	Canada
Simvastatin Tablets	Tablet	80 mg	Oral	Ranbaxy Inc.	Not applicable	Not applicable	Canada
Simvastatin Tablets 10mg	Tablet	10 mg	Oral	Prempharm Inc	2003-09-03	2005-08-05	Canada
Simvastatin Tablets 20mg	Tablet	20 mg	Oral	Prempharm Inc	2003-09-03	2005-08-05	Canada
Simvastatin Tablets 40mg	Tablet	40 mg	Oral	Prempharm Inc	2003-09-03	2005-08-05	Canada
Simvastatin Tablets 5mg	Tablet	5 mg	Oral	Prempharm Inc	2003-09-03	2005-08-05	Canada
Simvastatin Tablets 80mg	Tablet	80 mg	Oral	Prempharm Inc	2003-09-03	2005-08-05	Canada
Simvastatin-10	Tablet	10 mg	Oral	Pro Doc Limitee	2003-04-10	Not applicable	Canada
Simvastatin-20	Tablet	20 mg	Oral	Pro Doc Limitee	2003-04-10	Not applicable	Canada
Simvastatin-40	Tablet	40 mg	Oral	Pro Doc Limitee	2003-04-10	Not applicable	Canada
Simvastatin-80	Tablet	80 mg	Oral	Pro Doc Limitee	2009-06-15	Not applicable	Canada
Simvastatin-odan	Tablet	5 mg	Oral	Odan Laboratories Ltd	2012-02-14	2014-11-12	Canada
Simvastatin-odan	Tablet	40 mg	Oral	Odan Laboratories Ltd	2012-02-14	2014-11-12	Canada
Simvastatin-odan	Tablet	10 mg	Oral	Odan Laboratories Ltd	2012-02-14	2014-11-12	Canada
Simvastatin-odan	Tablet	80 mg	Oral	Odan Laboratories Ltd	2012-02-14	2014-11-17	Canada
Simvastatin-odan	Tablet	20 mg	Oral	Odan Laboratories Ltd	2012-02-14	2014-11-12	Canada
Taro-simvastatin	Tablet	40 mg	Oral	Taro Pharmaceuticals, Inc.	2005-08-10	2014-04-01	Canada
Taro-simvastatin	Tablet	10 mg	Oral	Taro Pharmaceuticals, Inc.	2005-08-10	2014-04-01	Canada
Taro-simvastatin	Tablet	20 mg	Oral	Taro Pharmaceuticals, Inc.	2005-08-10	2014-04-01	Canada
Teva-simvastatin	Tablet	40 mg	Oral	Teva	2004-03-22	Not applicable	Canada
Teva-simvastatin	Tablet	20 mg	Oral	Teva	2004-03-22	Not applicable	Canada
Teva-simvastatin	Tablet	80 mg	Oral	Teva	2004-03-22	Not applicable	Canada
Teva-simvastatin	Tablet	5 mg	Oral	Teva	2004-03-22	Not applicable	Canada
Teva-simvastatin	Tablet	10 mg	Oral	Teva	2004-03-22	Not applicable	Canada
Zocor	Tablet, film coated	80 mg/1	Oral	Merck Sharp & Dohme Limited	1991-12-23	Not applicable	US
Zocor	Tablet	40 mg	Oral	Merck Ltd.	1996-08-14	Not applicable	Canada
Zocor	Tablet, film coated	20 mg/1	Oral	Merck Sharp & Dohme Limited	1991-12-23	Not applicable	US
Zocor	Tablet	10 mg	Oral	Merck Ltd.	1990-12-31	Not applicable	Canada
Zocor	Tablet, film coated	5 mg/1	Oral	Merck Sharp & Dohme Limited	1991-12-23	Not applicable	US
Zocor	Tablet	80 mg	Oral	Merck Ltd.	1999-07-21	2014-05-06	Canada
Zocor	Tablet, film coated	40 mg/1	Oral	Merck Sharp & Dohme Limited	1991-12-23	Not applicable	US
Zocor	Tablet	20 mg	Oral	Merck Ltd.	1994-12-31	Not applicable	Canada
Zocor	Tablet	5 mg	Oral	Merck Ltd.	1991-12-31	2016-06-08	Canada
Zocor	Tablet, film coated	10 mg/1	Oral	Merck Sharp & Dohme Limited	1991-12-23	Not applicable	US
Zocor	Tablet, film coated	20 mg/1	Oral	Lake Erie Medical &Surgical Supply Dba Quality Care Products Llc	2011-08-08	2016-12-24	US
Zym-simvastatin	Tablet	80 mg	Oral	Zymcan Pharmaceuticals Inc	2009-02-26	2014-06-16	Canada
Zym-simvastatin	Tablet	20 mg	Oral	Zymcan Pharmaceuticals Inc	2009-02-26	2014-06-16	Canada
Zym-simvastatin	Tablet	5 mg	Oral	Zymcan Pharmaceuticals Inc	2009-02-26	2014-06-16	Canada
Zym-simvastatin	Tablet	40 mg	Oral	Zymcan Pharmaceuticals Inc	2009-02-26	2014-06-16	Canada
Zym-simvastatin	Tablet	10 mg	Oral	Zymcan Pharmaceuticals Inc	2009-02-26	2014-06-16	Canada

Approved Generic Prescription Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
Apo-simvastatin	Tablet	5 mg	Oral	Apotex Corporation	2002-12-20	Not applicable	Canada
Apo-simvastatin	Tablet	40 mg	Oral	Apotex Corporation	2002-12-20	Not applicable	Canada
Apo-simvastatin	Tablet	10 mg	Oral	Apotex Corporation	2002-12-20	Not applicable	Canada
Apo-simvastatin	Tablet	80 mg	Oral	Apotex Corporation	2002-12-20	Not applicable	Canada
Apo-simvastatin	Tablet	20 mg	Oral	Apotex Corporation	2002-12-20	Not applicable	Canada
Simvastatin	Tablet, film coated	40 mg/1	Oral	Mc Kesson Contract Packaging	2012-10-26	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Remedy Repack	2015-03-25	Not applicable	US
Simvastatin	Tablet, film coated	80 mg/1	Oral	Lucid Pharma Llc	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Major	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	5 mg/1	Oral	Mc Kesson Packaging Services A Buisness Unit Of Mc Kesson Corporation	2008-03-31	Not applicable	US
Simvastatin	Tablet	20 mg/1	Oral	Cobalt Laboratories	2006-12-20	Not applicable	US
Simvastatin	Tablet	40 mg/1	Oral	Cardinal Health	2011-05-02	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Biocon Limited	2015-12-17	Not applicable	US
Simvastatin	Tablet, film coated	80 mg/1	Oral	Aurobindo Pharma	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	5 mg/1	Oral	Accord Healthcare Limited	2013-09-02	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	Amerincan Health Packaging	2011-05-02	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Lupin Pharmaceuticals	2007-06-12	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	Blu Pharmceuticals Llc	2011-10-17	2017-05-09	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	Kaiser Foundations Hospitals	2016-09-28	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Life Line Home Care Services	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Rxchange Co	2008-02-26	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	A S Medication Solutions	2008-02-26	2017-06-20	US
Simvastatin	Tablet, film coated	5 mg/1	Oral	Lucid Pharma Llc	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	Aphena Pharma Solutions Tennessee, Inc.	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	Pd Rx Pharmaceuticals, Inc.	2008-02-26	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	Pd Rx Pharmaceuticals, Inc.	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Aurolife Pharma, LLC	2009-11-09	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	Av Pak	2014-12-02	Not applicable	US
Simvastatin	Tablet, film coated	5 mg/1	Oral	Kaiser Foundations Hospitals	2013-02-01	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Legacy Pharmaceutical Packaging	2007-06-01	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	Accord Healthcare Limited	2008-02-26	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Cardinal Health	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	Remedy Repack	2013-05-24	2017-02-18	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Nucare Pharmaceuticals, Inc.	2008-02-26	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Blu Pharmceuticals Llc	2008-02-01	2017-05-10	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Preferreed Pharmaceuticals Inc.	2012-02-28	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	State of Florida DOH Central Pharmacy	2014-01-01	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Avera Mc Kennan Hospital	2016-01-15	Not applicable	US
Simvastatin	Tablet, film coated	80 mg/1	Oral	Camber Pharmaceuticals	2014-12-09	Not applicable	US
Simvastatin	Tablet, film coated	5 mg/1	Oral	A S Medication Solutions	2006-12-20	2017-06-20	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Cardinal Health	2008-02-26	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	International Laboratories, Llc	2013-09-01	Not applicable	US
Simvastatin	Tablet, film coated	80 mg/1	Oral	Aphena Pharma Solutions Tennessee, Inc.	2011-10-17	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Unit Dose Services	2008-02-26	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Pd Rx Pharmaceuticals, Inc.	2011-06-13	Not applicable	US
Simvastatin	Tablet	10 mg/1	Oral	Remedy Repack	2011-07-25	2017-04-14	US
Simvastatin	Tablet	10 mg/1	Oral	Micro Labs Limited	2013-06-13	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Proficient Rx LP	2008-02-26	Not applicable	US
Simvastatin	Tablet, film coated	80 mg/1	Oral	Ingenus Pharmaceuticals Llc	2012-01-04	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Ncs Health Care Of Ky, Inc Dba Vangard Labs	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Remedy Repack	2016-03-28	Not applicable	US
Simvastatin	Tablet, film coated	5 mg/1	Oral	Mc Kesson Packaging Services A Buisness Unit Of Mc Kesson Corporation	2013-01-17	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	Cadila Pharnmaceuticals	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	State of Florida DOH Central Pharmacy	2014-01-01	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	Teva	2006-06-27	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Contract Pharmacy Services Pa	2010-06-17	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	Dr Reddy's Laboratories	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	bryant ranch prepack	2008-02-26	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	Zydus Pharmaceuticals Usa, Inc.	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Cardinal Health	2011-10-03	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	State of Florida DOH Central Pharmacy	2013-01-01	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Lake Erie Medical Dba Quality Care Produts Llc	2011-11-22	Not applicable	US
Simvastatin	Tablet, film coated	5 mg/1	Oral	Blu Pharmceuticals Llc	2011-10-17	2017-05-09	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Kaiser Foundations Hospitals	2016-09-28	Not applicable	US
Simvastatin	Tablet	20 mg/1	Oral	Physicians Total Care, Inc.	2008-07-21	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	International Laboratories, Llc	2010-11-28	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	Aidarex Pharmaceuticals LLC	2008-02-26	Not applicable	US
Simvastatin	Tablet, film coated	80 mg/1	Oral	A S Medication Solutions	2008-02-26	2017-06-20	US
Simvastatin	Tablet, film coated	80 mg/1	Oral	Cardinal Health	2006-12-20	2017-05-11	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Remedy Repack	2017-06-21	Not applicable	US
Simvastatin	Tablet, film coated	80 mg/1	Oral	Aphena Pharma Solutions Tennessee, Inc.	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Pd Rx Pharmaceuticals, Inc.	2008-02-26	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Lake Erie Medical Dba Quality Care Produts Llc	2012-03-29	Not applicable	US
Simvastatin	Tablet, film coated	5 mg/1	Oral	Av Pak	2014-12-02	Not applicable	US
Simvastatin	Tablet	80 mg/1	Oral	Micro Labs Limited	2013-06-13	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Ranbaxy Inc.	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Mylan Institutional	2006-07-10	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Major	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	80 mg/1	Oral	Clinical Solutions Wholsesale	2008-02-26	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Mc Kesson Packaging Services A Buisness Unit Of Mc Kesson Corporation	2012-11-22	Not applicable	US
Simvastatin	Tablet, film coated	80 mg/1	Oral	Cadila Pharnmaceuticals	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	State of Florida DOH Central Pharmacy	2014-01-01	Not applicable	US
Simvastatin	Tablet, film coated	80 mg/1	Oral	Teva	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	5 mg/1	Oral	Contract Pharmacy Services Pa	2010-08-25	Not applicable	US
Simvastatin	Tablet, film coated	80 mg/1	Oral	Dr Reddy's Laboratories	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	International Laboratories, Llc	2013-09-19	Not applicable	US
Simvastatin	Tablet, film coated	80 mg/1	Oral	Zydus Pharmaceuticals Usa, Inc.	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	5 mg/1	Oral	Cardinal Health	2011-10-17	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	Proficient Rx LP	2008-02-26	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	Lupin Pharmaceuticals	2007-06-12	Not applicable	US
Simvastatin	Tablet, film coated	80 mg/1	Oral	Blenheim Pharmacal, Inc.	2015-03-26	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Mc Kesson Packaging Services A Buisness Unit Of Mc Kesson Corporation	2008-03-31	Not applicable	US
Simvastatin	Tablet, film coated	5 mg/1	Oral	North Star Rx Llc	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	5 mg/1	Oral	Teva	2006-06-27	Not applicable	US
Simvastatin	Tablet, film coated	5 mg/1	Oral	Cadila Pharnmaceuticals	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Med Vantx, Inc.	2006-12-20	Not applicable	US
Simvastatin	Tablet	20 mg/1	Oral	Rebel Distributors	2008-07-21	Not applicable	US
Simvastatin	Tablet, film coated	80 mg/1	Oral	Amerincan Health Packaging	2011-05-02	2017-06-30	US
Simvastatin	Tablet, film coated	5 mg/1	Oral	Zydus Pharmaceuticals Usa, Inc.	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	80 mg/1	Oral	Blu Pharmceuticals Llc	2011-10-17	2017-05-09	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Ncs Health Care Of Ky, Inc Dba Vangard Labs	2015-12-02	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Mc Kesson Contract Packaging	2011-10-14	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Rebel Distributors	2008-02-26	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	Biocon Pharma Inc,	2015-12-17	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Lucid Pharma Llc	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Safecor Health, LLC	2014-09-30	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Remedy Repack	2016-12-13	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	Unit Dose Services	2008-02-26	Not applicable	US
Simvastatin	Tablet	10 mg/1	Oral	Cobalt Laboratories	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	80 mg/1	Oral	Av Pak	2014-12-02	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Ncs Health Care Of Ky, Inc Dba Vangard Labs	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Doh Central Pharmacy	2009-07-01	Not applicable	US
Simvastatin	Tablet, film coated	80 mg/1	Oral	Accord Healthcare Limited	2008-02-26	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Directrx	2014-01-01	Not applicable	US
Simvastatin	Tablet, film coated	80 mg/1	Oral	Lupin Pharmaceuticals	2015-11-23	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	Aurolife Pharma, LLC	2009-11-09	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	North Star Rx Llc	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	80 mg/1	Oral	Remedy Repack	2013-02-19	2017-08-31	US
Simvastatin	Tablet, film coated	5 mg/1	Oral	Blu Pharmceuticals Llc	2008-02-01	2017-05-10	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	Preferreed Pharmaceuticals Inc.	2012-02-28	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Camber Pharmaceuticals	2014-12-09	Not applicable	US
Simvastatin	Tablet, film coated	80 mg/1	Oral	A S Medication Solutions	2008-02-26	2017-06-20	US
Simvastatin	Tablet, film coated	80 mg/1	Oral	Rebel Distributors	2008-02-26	Not applicable	US
Simvastatin	Tablet, film coated	80 mg/1	Oral	Biocon Pharma Inc,	2015-12-17	Not applicable	US
Simvastatin	Tablet	40 mg/1	Oral	Remedy Repack	2011-07-08	2016-10-13	US
Simvastatin	Tablet, film coated	80 mg/1	Oral	Pd Rx Pharmaceuticals, Inc.	2008-02-26	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Ingenus Pharmaceuticals Llc	2012-01-04	Not applicable	US
Simvastatin	Tablet, film coated	5 mg/1	Oral	Ncs Health Care Of Ky, Inc Dba Vangard Labs	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Lake Erie Medical Dba Quality Care Produts Llc	2009-07-14	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	State of Florida DOH Central Pharmacy	2013-01-01	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Preferreed Pharmaceuticals Inc.	2012-03-29	Not applicable	US
Simvastatin	Tablet	5 mg/1	Oral	Physicians Total Care, Inc.	2009-09-24	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	Clinical Solutions Wholsesale	2007-06-12	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	Cardinal Health	2013-04-04	Not applicable	US
Simvastatin	Tablet, film coated	5 mg/1	Oral	Carilion Materials Management	2006-06-27	Not applicable	US
Simvastatin	Tablet, film coated	80 mg/1	Oral	St. Marys Medical Park Pharmacy	2008-02-26	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	bryant ranch prepack	2008-02-26	Not applicable	US
Simvastatin	Tablet, film coated	5 mg/1	Oral	Biocon Limited	2015-12-17	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Aurobindo Pharma	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	Lupin Pharmaceuticals	2007-06-12	Not applicable	US
Simvastatin	Tablet, film coated	80 mg/1	Oral	Legacy Pharmaceutical Packaging	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	5 mg/1	Oral	State of Florida DOH Central Pharmacy	2014-01-01	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Teva	2006-06-27	Not applicable	US
Simvastatin	Tablet, film coated	5 mg/1	Oral	Contract Pharmacy Services Pa	2010-08-25	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Dr Reddy's Laboratories	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	80 mg/1	Oral	bryant ranch prepack	2008-02-26	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Zydus Pharmaceuticals Usa, Inc.	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Cardinal Health	2011-10-03	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Mc Kesson Contract Packaging	2013-02-19	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Directrx	2014-01-01	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Lupin Pharmaceuticals	2015-12-02	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Blenheim Pharmacal, Inc.	2014-02-10	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	Mc Kesson Packaging Services A Buisness Unit Of Mc Kesson Corporation	2008-03-31	Not applicable	US
Simvastatin	Tablet	40 mg/1	Oral	Cobalt Laboratories	2006-12-20	Not applicable	US
Simvastatin	Tablet	20 mg/1	Oral	Cardinal Health	2011-05-02	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Biocon Limited	2015-12-17	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Med Vantx, Inc.	2006-06-27	Not applicable	US
Simvastatin	Tablet	5 mg/1	Oral	Rebel Distributors	2009-09-24	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Amerincan Health Packaging	2011-05-02	Not applicable	US
Simvastatin	Tablet, film coated	80 mg/1	Oral	Lupin Pharmaceuticals	2007-06-12	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Blu Pharmceuticals Llc	2011-10-17	2017-05-09	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	Ncs Health Care Of Ky, Inc Dba Vangard Labs	2007-06-12	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	Mc Kesson Contract Packaging	2011-10-13	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Rxchange Co	2014-11-27	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Legacy Pharmaceutical Packaging	2015-12-02	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	Lucid Pharma Llc	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Aphena Pharma Solutions Tennessee, Inc.	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Red Pharm Drug, Inc.	2008-02-26	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Pd Rx Pharmaceuticals, Inc.	2015-08-12	Not applicable	US
Simvastatin	Tablet, film coated	80 mg/1	Oral	Aurolife Pharma, LLC	2009-11-09	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Av Pak	2014-12-02	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	Ncs Health Care Of Ky, Inc Dba Vangard Labs	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Legacy Pharmaceutical Packaging	2007-06-01	2017-08-31	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Accord Healthcare Limited	2008-02-26	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	Cardinal Health	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	H.J. Harkins Company	2008-02-26	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Nucare Pharmaceuticals, Inc.	2008-02-26	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Blu Pharmceuticals Llc	2008-02-01	2017-05-10	US
Simvastatin	Tablet, film coated	80 mg/1	Oral	Kaiser Foundations Hospitals	2016-09-28	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	State of Florida DOH Central Pharmacy	2014-11-01	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	International Laboratories, Llc	2010-11-22	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Aidarex Pharmaceuticals LLC	2008-02-26	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	A S Medication Solutions	2008-02-26	2017-06-20	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Cardinal Health	2006-12-20	2017-05-11	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	International Laboratories, Llc	2013-09-01	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Aphena Pharma Solutions Tennessee, Inc.	2011-10-17	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Unit Dose Services	2008-02-26	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	Pd Rx Pharmaceuticals, Inc.	2006-06-27	Not applicable	US
Simvastatin	Tablet	40 mg/1	Oral	Remedy Repack	2011-08-01	2017-03-16	US
Simvastatin	Tablet	20 mg/1	Oral	Micro Labs Limited	2013-06-13	Not applicable	US
Simvastatin	Tablet, film coated	5 mg/1	Oral	Ranbaxy Inc.	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	Mylan Institutional	2006-07-10	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Ncs Health Care Of Ky, Inc Dba Vangard Labs	2012-06-14	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Clinical Solutions Wholsesale	2008-02-26	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	Mc Kesson Packaging Services A Buisness Unit Of Mc Kesson Corporation	2012-12-20	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Cadila Pharnmaceuticals	2006-12-20	Not applicable	US
Simvastatin	Tablet	20 mg/1	Oral	Remedy Repack	2010-09-21	2016-10-13	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Remedy Repack	2016-12-13	Not applicable	US
Simvastatin	Tablet, film coated	80 mg/1	Oral	Unit Dose Services	2008-02-26	Not applicable	US
Simvastatin	Tablet, film coated	5 mg/1	Oral	Ncs Health Care Of Ky, Inc Dba Vangard Labs	2007-08-16	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Doh Central Pharmacy	2009-07-01	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	State of Florida DOH Central Pharmacy	2009-07-01	Not applicable	US
Simvastatin	Tablet, film coated	5 mg/1	Oral	Nucare Pharmaceuticals, Inc.	2006-06-27	Not applicable	US
Simvastatin	Tablet	40 mg/1	Oral	Physicians Total Care, Inc.	2008-07-08	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Lake Erie Medical Dba Quality Care Produts Llc	2008-02-26	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	Cardinal Health	2006-12-20	2017-05-11	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Unit Dose Services	2008-02-26	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	St. Marys Medical Park Pharmacy	2008-02-26	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Ranbaxy Inc.	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Ready Meds	2008-02-26	Not applicable	US
Simvastatin	Tablet, film coated	5 mg/1	Oral	Aurobindo Pharma	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Lupin Pharmaceuticals	2015-12-02	Not applicable	US
Simvastatin	Tablet	20 mg/1	Oral	Legacy Pharmaceutical Packaging	2010-10-01	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Lupin Pharmaceuticals	2007-06-14	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Blenheim Pharmacal, Inc.	2015-03-26	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	North Star Rx Llc	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	Remedy Repack	2011-01-20	2017-12-01	US
Simvastatin	Tablet	40 mg/1	Oral	Rebel Distributors	2008-07-08	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Preferreed Pharmaceuticals Inc.	2014-07-03	Not applicable	US
Simvastatin	Tablet, film coated	5 mg/1	Oral	Camber Pharmaceuticals	2014-12-09	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	A S Medication Solutions	2008-02-26	2017-06-20	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Rebel Distributors	2008-02-26	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Biocon Pharma Inc,	2015-12-17	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Lupin Pharmaceuticals	2007-06-14	Not applicable	US
Simvastatin	Tablet	80 mg/1	Oral	Legacy Pharmaceutical Packaging	2007-06-01	2017-02-02	US
Simvastatin	Tablet, film coated	5 mg/1	Oral	Lupin Pharmaceuticals	2009-07-14	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Aurolife Pharma, LLC	2009-11-09	Not applicable	US
Simvastatin	Tablet, film coated	80 mg/1	Oral	North Star Rx Llc	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Cardinal Health	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	Blu Pharmceuticals Llc	2008-02-01	2017-05-10	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Preferreed Pharmaceuticals Inc.	2012-02-28	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Camber Pharmaceuticals	2014-12-03	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	A S Medication Solutions	2008-02-26	2017-06-20	US
Simvastatin	Tablet, film coated	80 mg/1	Oral	Pd Rx Pharmaceuticals, Inc.	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	Unit Dose Services	2008-02-26	Not applicable	US
Simvastatin	Tablet	20 mg/1	Oral	Remedy Repack	2011-07-15	2017-03-16	US
Simvastatin	Tablet	5 mg/1	Oral	Micro Labs Limited	2013-06-13	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Ingenus Pharmaceuticals Llc	2012-01-04	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	Ncs Health Care Of Ky, Inc Dba Vangard Labs	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	Nucare Pharmaceuticals, Inc.	2008-02-26	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	State of Florida DOH Central Pharmacy	2013-01-01	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Preferreed Pharmaceuticals Inc.	2012-03-29	Not applicable	US
Simvastatin	Tablet, film coated	5 mg/1	Oral	Dr Reddy's Laboratories	2007-08-16	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	Lake Erie Medical Dba Quality Care Produts Llc	2017-04-06	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Cardinal Health	2013-04-04	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	St. Marys Medical Park Pharmacy	2014-04-21	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	bryant ranch prepack	2008-02-26	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	Biocon Limited	2015-12-17	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Aurobindo Pharma	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Aphena Pharma Solutions Tennessee, Inc.	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Amerincan Health Packaging	2016-06-20	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Pd Rx Pharmaceuticals, Inc.	2011-06-13	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Remedy Repack	2013-05-14	2016-10-13	US
Simvastatin	Tablet	40 mg/1	Oral	Micro Labs Limited	2013-06-13	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	Ranbaxy Inc.	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Mylan Institutional	2006-07-10	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	Major	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Clinical Solutions Wholsesale	2008-02-26	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Mc Kesson Packaging Services A Buisness Unit Of Mc Kesson Corporation	2012-11-22	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Cadila Pharnmaceuticals	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	State of Florida DOH Central Pharmacy	2014-01-01	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Teva	2006-06-27	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Contract Pharmacy Services Pa	2010-06-17	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Dr Reddy's Laboratories	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	5 mg/1	Oral	Nucare Pharmaceuticals, Inc.	2013-09-02	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Zydus Pharmaceuticals Usa, Inc.	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	Cardinal Health	2011-10-03	Not applicable	US
Simvastatin	Tablet, film coated	5 mg/1	Oral	H.J. Harkins Company	2007-08-16	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Proficient Rx LP	2008-02-26	Not applicable	US
Simvastatin	Tablet, film coated	80 mg/1	Oral	Lupin Pharmaceuticals	2015-12-02	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Blenheim Pharmacal, Inc.	2015-02-27	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Mc Kesson Packaging Services A Buisness Unit Of Mc Kesson Corporation	2008-03-31	Not applicable	US
Simvastatin	Tablet	80 mg/1	Oral	Cobalt Laboratories	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	80 mg/1	Oral	Avera Mc Kennan Hospital	2015-12-02	Not applicable	US
Simvastatin	Tablet, film coated	80 mg/1	Oral	Biocon Limited	2015-12-17	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Med Vantx, Inc.	2006-12-20	Not applicable	US
Simvastatin	Tablet	10 mg/1	Oral	Rebel Distributors	2007-02-02	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Amerincan Health Packaging	2011-05-02	2018-02-28	US
Simvastatin	Tablet, film coated	5 mg/1	Oral	Lupin Pharmaceuticals	2009-07-14	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Blu Pharmceuticals Llc	2011-10-17	2017-05-09	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Ncs Health Care Of Ky, Inc Dba Vangard Labs	2007-06-14	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Mc Kesson Contract Packaging	2011-08-18	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	Lake Erie Medical Dba Quality Care Produts Llc	2008-02-26	Not applicable	US
Simvastatin	Tablet, film coated	5 mg/1	Oral	Biocon Pharma Inc,	2015-12-17	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Lucid Pharma Llc	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	5 mg/1	Oral	Aphena Pharma Solutions Tennessee, Inc.	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Unit Dose Services	2008-02-26	Not applicable	US
Simvastatin	Tablet	20 mg/1	Oral	Remedy Repack	2011-12-08	2017-12-09	US
Simvastatin	Tablet	5 mg/1	Oral	Cobalt Laboratories	2006-12-20	2017-04-29	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Av Pak	2014-12-02	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Ncs Health Care Of Ky, Inc Dba Vangard Labs	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	Doh Central Pharmacy	2009-07-01	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Accord Healthcare Limited	2008-02-26	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	Remedy Repack	2015-03-17	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	H.J. Harkins Company	2008-02-26	Not applicable	US
Simvastatin	Tablet, film coated	5 mg/1	Oral	Aidarex Pharmaceuticals LLC	2013-09-02	Not applicable	US
Simvastatin	Tablet, film coated	80 mg/1	Oral	Blu Pharmceuticals Llc	2008-02-01	2017-05-10	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Kaiser Foundations Hospitals	2016-09-28	Not applicable	US
Simvastatin	Tablet	10 mg/1	Oral	Physicians Total Care, Inc.	2007-02-02	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	International Laboratories, Llc	2010-11-27	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Aidarex Pharmaceuticals LLC	2008-02-26	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	A S Medication Solutions	2008-02-26	2017-06-20	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Cardinal Health	2006-12-20	2017-05-11	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	Clinical Solutions Wholsesale	2007-06-01	Not applicable	US
Simvastatin	Tablet	80 mg/1	Oral	Rebel Distributors	2007-05-23	Not applicable	US
Simvastatin	Tablet, film coated	80 mg/1	Oral	Preferreed Pharmaceuticals Inc.	2014-10-21	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	Camber Pharmaceuticals	2014-12-09	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	A S Medication Solutions	2008-02-26	2017-06-20	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	Rebel Distributors	2008-02-26	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Biocon Pharma Inc,	2015-12-17	Not applicable	US
Simvastatin	Tablet	40 mg/1	Oral	Remedy Repack	2011-04-14	2016-10-13	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	Remedy Repack	2016-12-14	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	Ingenus Pharmaceuticals Llc	2012-01-04	Not applicable	US
Simvastatin	Tablet, film coated	80 mg/1	Oral	Ncs Health Care Of Ky, Inc Dba Vangard Labs	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	5 mg/1	Oral	A S Medication Solutions	2013-09-02	2017-06-20	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	State of Florida DOH Central Pharmacy	2009-07-01	Not applicable	US
Simvastatin	Tablet, film coated	5 mg/1	Oral	Nucare Pharmaceuticals, Inc.	2014-12-09	Not applicable	US
Simvastatin	Tablet	80 mg/1	Oral	Physicians Total Care, Inc.	2007-05-23	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	Lake Erie Medical Dba Quality Care Produts Llc	2008-02-26	Not applicable	US
Simvastatin	Tablet, film coated	5 mg/1	Oral	Cardinal Health	2006-06-27	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Unit Dose Services	2008-02-26	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	St. Marys Medical Park Pharmacy	2008-02-26	Not applicable	US
Simvastatin	Tablet, film coated	80 mg/1	Oral	Ranbaxy Inc.	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Ready Meds	2008-02-26	Not applicable	US
Simvastatin	Tablet, film coated	10 mg/1	Oral	Aurobindo Pharma	2006-12-20	Not applicable	US
Simvastatin	Tablet, film coated	80 mg/1	Oral	Lupin Pharmaceuticals	2015-12-02	Not applicable	US
Simvastatin	Tablet	40 mg/1	Oral	Legacy Pharmaceutical Packaging	2010-10-01	Not applicable	US
Simvastatin	Tablet, film coated	40 mg/1	Oral	Lupin Pharmaceuticals	2015-11-23	Not applicable	US
Simvastatin	Tablet, film coated	5 mg/1	Oral	Aurolife Pharma, LLC	2009-11-09	Not applicable	US
Simvastatin	Tablet, film coated	20 mg/1	Oral	North Star Rx Llc	2006-12-20	Not applicable	US
Simvastatin	Tablet	40 mg/1	Oral	Remedy Repack	2010-12-30	2017-12-07	US

Approved Over the Counter Products

Not Available

Unapproved/Other Products

Not Available

International Brands

Name	Company
Cholestat	Kalbe
Colemin	Biohorm
Labistatin	Sandoz
Lipex	Merck Sharp & Dohme
Lodales	Sanofi-Aventis
Medipo	Mediolanum Farmaceutici
Nivelipol	Temis-Lostalo
Simovil	Merck Sharp & Dohme
Sinvacor	Merck Sharp & Dohme
Sivastin	Sigma-Tau
Sivatin	Rowex
Sivinar	Anfarm
Sorfox	Galex
Sotovastin	Bros
Starezin	Leovan Pharmaceuticals
Starstat	Lupin
Starzoko	Daewoong
Stasiva	Pharmanel
Statex	Pliva
Staticor	Darnitsa
Statinal	Alet Pharmaceuticals
Stativer	Iapharm

Brand mixtures

Name	Labeller	Ingredients
Cholib	Abbott	Fenofibrate Simvastatin
Ezetimibe and Simvastatin	Impax Generics	Ezetimibe Simvastatin
Simcor	Physicians Total Care, Inc.	Niacin Simvastatin
Vytorin	Rebel Distributors	Ezetimibe Simvastatin

Categories

UNII

AGG2FN16EV

CAS number

79902-63-9

Weight

Average: 418.5662
Monoisotopic: 418.271924326

Chemical Formula

C₂₅H₃₈O₅

InChI Key

RYMZZMVNJRMUDD-HGQWONQESA-N

InChI

InChI=1S/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23-/m0/s1

IUPAC Name

(1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate

SMILES

[H][C@]12[C@H](C[C@@H](C)C=C1C=C[C@H](C)[C@@H]2CC[C@@H]1C[C@@H](O)CC(=O)O1)OC(=O)C(C)(C)CC

Pharmacology

Indication

For the treatment of hypercholesterolemia and for the reduction in the risk of cardiac heart disease mortality and cardiovascular events. It can also be used in adolescent patients for the treatment of heterozygous familial hypercholesterolemia.

Structured Indications

Pharmacodynamics

Simvastatin, the methylated form of lovastatin, is an oral antilipemic agent which inhibits HMG-CoA reductase. Simvastatin is used in the treatment of primary hypercholesterolemia and is effective in reducing total and LDL-cholesterol as well as plasma triglycerides and apolipoprotein B.

Mechanism of action

Simvastatin is a prodrug in which the 6-membered lactone ring of simvastatin is hydrolyzed in vivo to generate the beta,delta-dihydroxy acid, an active metabolite structurally similar to HMG-CoA (hydroxymethylglutaryl CoA). Once hydrolyzed, simvastatin competes with HMG-CoA for HMG-CoA reductase, a hepatic microsomal enzyme. Interference with the activity of this enzyme reduces the quantity of mevalonic acid, a precursor of cholesterol.

Target	Kind	Pharmacological action	Actions	Organism	UniProt ID
3-hydroxy-3-methylglutaryl-coenzyme A reductase	Protein	yes	inhibitor	Human	P04035	details
Integrin beta-2	Protein	no	other	Human	P05107	details
Integrin alpha-L	Protein	unknown	inhibitor	Human	P20701	details

Absorption

Absorption of simvastatin, estimated relative to an intravenous reference dose, in each of two animal species tested, averaged about 85% of an oral dose. In animal studies, after oral dosing, simvastatin achieved substantially higher concentrations in the liver than in non-target tissues. However, because simvastatin undergoes extensive first-pass metabolism, the availability of the drug in the systemic is low. Peak plasma concentration occurs 1.3 - 2.4 hours after administration.

Volume of distribution

Simvastatin can cross the blood-brain-barrier.

Protein binding

Both simvastatin and its β-hydroxyacid metabolite are highly bound (approximately 95%) to human plasma proteins.

Metabolism

Hepatic, simvastatin is a substrate for CYP3A4. The major active metabolites of simvastatin are β-hydroxyacid metabolite and its 6'-hydroxy, 6'-hydroxymethyl, and 6'-exomethylene derivatives

Substrate	Enzymes	Product
Simvastatin	Cytochrome P450 3A4	simvastatin hydroxy acid	Details

Route of elimination

Following an oral dose of 14C-labeled simvastatin in man, 13% of the dose was excreted in urine and 60% in feces.

Half life

3 hours

Clearance

Not Available

Toxicity

The most common adverse reactions that lead to discontinuation of therapy include gastrointestinal disorders (0.5%), myalgia (0.1%), and arthralgia (0.1%).

Affected organisms

Humans and other mammals

Pathways

Pathway	Category	SMPDB ID
Simvastatin Action Pathway	Drug action	SMP00082

Pharmacogenomic Effects/ADRs

Interacting Gene/Enzyme	Allele name	Genotype(s)	Defining Change(s)	Type(s)	Description	Details
Kinesin-like protein KIF6	---	(C;C) / (C;T)	C Allele	Effect Directly Studied	Improved response to statin drugs	Details
3-hydroxy-3-methylglutaryl-coenzyme A reductase	---	(A;T)	T Allele	Effect Directly Studied	Reduced response to statin drugs	Details
Solute carrier organic anion transporter family member 1B1	SLCO1B1*5	(C;C) / (C;T)	T > C	ADR Directly Studied	Myotoxicity	Details

Interactions

Drug Interactions

Drug	Interaction	Drug group
1,10-Phenanthroline	The serum concentration of Simvastatin can be increased when it is combined with 1,10-Phenanthroline.	Experimental
3,4-Dichloroisocoumarin	The serum concentration of Simvastatin can be increased when it is combined with 3,4-Dichloroisocoumarin.	Experimental
4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE	The serum concentration of Simvastatin can be increased when it is combined with 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE.	Experimental
Abiraterone	The serum concentration of Simvastatin can be increased when it is combined with Abiraterone.	Approved
Acebutolol	The serum concentration of Acebutolol can be increased when it is combined with Simvastatin.	Approved
Acenocoumarol	Simvastatin may increase the anticoagulant activities of Acenocoumarol.	Approved
Acetaminophen	The serum concentration of Acetaminophen can be increased when it is combined with Simvastatin.	Approved
Acetylsalicylic acid	The serum concentration of Acetylsalicylic acid can be increased when it is combined with Simvastatin.	Approved, Vet Approved
Afatinib	The serum concentration of Afatinib can be increased when it is combined with Simvastatin.	Approved
Aldosterone	The serum concentration of Aldosterone can be increased when it is combined with Simvastatin.	Experimental
Alitretinoin	The serum concentration of Alitretinoin can be increased when it is combined with Simvastatin.	Approved, Investigational
Alogliptin	The serum concentration of Simvastatin can be increased when it is combined with Alogliptin.	Approved
Alpha-1-proteinase inhibitor	The serum concentration of Simvastatin can be increased when it is combined with Alpha-1-proteinase inhibitor.	Approved
Aluminum hydroxide	The serum concentration of Simvastatin can be decreased when it is combined with Aluminum hydroxide.	Approved
Ambrisentan	The serum concentration of Ambrisentan can be increased when it is combined with Simvastatin.	Approved, Investigational
Amiodarone	The serum concentration of Simvastatin can be increased when it is combined with Amiodarone.	Approved, Investigational
Amitriptyline	The serum concentration of Amitriptyline can be increased when it is combined with Simvastatin.	Approved
Amlodipine	The serum concentration of Simvastatin can be increased when it is combined with Amlodipine.	Approved
Amodiaquine	The serum concentration of Amodiaquine can be increased when it is combined with Simvastatin.	Approved
Amprenavir	The serum concentration of Simvastatin can be increased when it is combined with Amprenavir.	Approved
Antithrombin III human	The serum concentration of Simvastatin can be increased when it is combined with Antithrombin III human.	Approved
Apixaban	The serum concentration of Simvastatin can be increased when it is combined with Apixaban.	Approved
Aprepitant	The serum concentration of Simvastatin can be increased when it is combined with Aprepitant.	Approved, Investigational
Aprotinin	The serum concentration of Simvastatin can be increased when it is combined with Aprotinin.	Approved, Withdrawn
Argatroban	The serum concentration of Simvastatin can be increased when it is combined with Argatroban.	Approved, Investigational
Aripiprazole	The serum concentration of Aripiprazole can be decreased when it is combined with Simvastatin.	Approved, Investigational
Arsenic trioxide	The serum concentration of Arsenic trioxide can be increased when it is combined with Simvastatin.	Approved, Investigational
Artemether	The metabolism of Simvastatin can be decreased when combined with Artemether.	Approved
Atazanavir	The serum concentration of Simvastatin can be increased when it is combined with Atazanavir.	Approved, Investigational
Atenolol	The serum concentration of Atenolol can be increased when it is combined with Simvastatin.	Approved
Atomoxetine	The metabolism of Simvastatin can be decreased when combined with Atomoxetine.	Approved
Axitinib	The serum concentration of Axitinib can be increased when it is combined with Simvastatin.	Approved, Investigational
Azithromycin	Azithromycin may increase the myopathic rhabdomyolysis activities of Simvastatin.	Approved
Batimastat	The serum concentration of Simvastatin can be increased when it is combined with Batimastat.	Experimental
Benazepril	The serum concentration of Simvastatin can be increased when it is combined with Benazepril.	Approved, Investigational
Benzamidine	The serum concentration of Simvastatin can be increased when it is combined with Benzamidine.	Experimental
Betamethasone	The serum concentration of Betamethasone can be increased when it is combined with Simvastatin.	Approved, Vet Approved
Betaxolol	The metabolism of Simvastatin can be decreased when combined with Betaxolol.	Approved
Bexarotene	The serum concentration of Simvastatin can be decreased when it is combined with Bexarotene.	Approved, Investigational
Bezafibrate	Bezafibrate may increase the myopathic rhabdomyolysis activities of Simvastatin.	Approved
Bismuth Subcitrate	The serum concentration of Simvastatin can be decreased when it is combined with Bismuth Subcitrate.	Approved
Bivalirudin	The serum concentration of Simvastatin can be increased when it is combined with Bivalirudin.	Approved, Investigational
Boceprevir	The serum concentration of Simvastatin can be increased when it is combined with Boceprevir.	Approved, Investigational
Bortezomib	The metabolism of Simvastatin can be decreased when combined with Bortezomib.	Approved, Investigational
Bosentan	The metabolism of Simvastatin can be increased when combined with Bosentan.	Approved, Investigational
Bosutinib	The serum concentration of Bosutinib can be increased when it is combined with Simvastatin.	Approved
Brentuximab vedotin	The serum concentration of Brentuximab vedotin can be increased when it is combined with Simvastatin.	Approved
Bromocriptine	The serum concentration of Bromocriptine can be increased when it is combined with Simvastatin.	Approved, Investigational
Bupropion	The metabolism of Simvastatin can be decreased when combined with Bupropion.	Approved
Cabazitaxel	The serum concentration of Cabazitaxel can be increased when it is combined with Simvastatin.	Approved
Caffeine	The serum concentration of Caffeine can be increased when it is combined with Simvastatin.	Approved
Calcium Carbonate	The serum concentration of Simvastatin can be decreased when it is combined with Calcium carbonate.	Approved
Camptothecin	The serum concentration of Camptothecin can be increased when it is combined with Simvastatin.	Experimental
Canagliflozin	The serum concentration of Canagliflozin can be increased when it is combined with Simvastatin.	Approved
Candoxatril	The serum concentration of Simvastatin can be increased when it is combined with Candoxatril.	Experimental
Candoxatrilat	The serum concentration of Simvastatin can be increased when it is combined with Candoxatrilat.	Experimental
Captopril	The serum concentration of Simvastatin can be increased when it is combined with Captopril.	Approved
Carbamazepine	The metabolism of Simvastatin can be increased when combined with Carbamazepine.	Approved, Investigational
Carfilzomib	The serum concentration of Carfilzomib can be increased when it is combined with Simvastatin.	Approved
Celecoxib	The metabolism of Simvastatin can be decreased when combined with Celecoxib.	Approved, Investigational
Ceritinib	The serum concentration of Simvastatin can be increased when it is combined with Ceritinib.	Approved
Cerivastatin	The serum concentration of Cerivastatin can be increased when it is combined with Simvastatin.	Withdrawn
Chloroquine	The metabolism of Simvastatin can be decreased when combined with Chloroquine.	Approved, Vet Approved
Chlorpromazine	The serum concentration of Chlorpromazine can be increased when it is combined with Simvastatin.	Approved, Vet Approved
Cholecalciferol	The metabolism of Simvastatin can be decreased when combined with Cholecalciferol.	Approved, Nutraceutical
Chymostatin	The serum concentration of Simvastatin can be increased when it is combined with Chymostatin.	Experimental
Cilastatin	The serum concentration of Simvastatin can be increased when it is combined with Cilastatin.	Approved
Cilazapril	The serum concentration of Simvastatin can be increased when it is combined with Cilazapril.	Approved
Cilostazol	The serum concentration of Cilostazol can be increased when it is combined with Simvastatin.	Approved
Cimetidine	The serum concentration of Cimetidine can be increased when it is combined with Simvastatin.	Approved
Cinacalcet	The metabolism of Simvastatin can be decreased when combined with Cinacalcet.	Approved
Ciprofloxacin	The serum concentration of Ciprofloxacin can be increased when it is combined with Simvastatin.	Approved, Investigational
Cisplatin	The serum concentration of Cisplatin can be increased when it is combined with Simvastatin.	Approved
Citalopram	The serum concentration of Citalopram can be increased when it is combined with Simvastatin.	Approved
Clarithromycin	The serum concentration of Simvastatin can be increased when it is combined with Clarithromycin.	Approved
Clemastine	The metabolism of Simvastatin can be decreased when combined with Clemastine.	Approved
Clobazam	The serum concentration of Clobazam can be increased when it is combined with Simvastatin.	Approved, Illicit
Clomifene	The serum concentration of Clomifene can be increased when it is combined with Simvastatin.	Approved, Investigational
Clomipramine	The metabolism of Simvastatin can be decreased when combined with Clomipramine.	Approved, Vet Approved
Clonidine	The serum concentration of Clonidine can be increased when it is combined with Simvastatin.	Approved
Clopidogrel	The metabolism of Simvastatin can be decreased when combined with Clopidogrel.	Approved, Nutraceutical
Clotrimazole	The metabolism of Simvastatin can be decreased when combined with Clotrimazole.	Approved, Vet Approved
Clozapine	The serum concentration of Clozapine can be increased when it is combined with Simvastatin.	Approved
Cobicistat	The serum concentration of Simvastatin can be increased when it is combined with Cobicistat.	Approved
Cobimetinib	The serum concentration of Cobimetinib can be increased when it is combined with Simvastatin.	Approved
Cocaine	The metabolism of Simvastatin can be decreased when combined with Cocaine.	Approved, Illicit
Colchicine	Colchicine may increase the myopathic rhabdomyolysis activities of Simvastatin.	Approved
Conivaptan	The serum concentration of Simvastatin can be increased when it is combined with Conivaptan.	Approved, Investigational
Conjugated estrogens	The serum concentration of Conjugated Equine Estrogens can be increased when it is combined with Simvastatin.	Approved
Crizotinib	The metabolism of Simvastatin can be decreased when combined with Crizotinib.	Approved
Cyclosporine	The serum concentration of Simvastatin can be increased when it is combined with Cyclosporine.	Approved, Investigational, Vet Approved
Cyclosporine	The metabolism of Simvastatin can be decreased when combined with Cyclosporine.	Approved, Investigational, Vet Approved
Cyproterone acetate	The serum concentration of Simvastatin can be increased when it is combined with Cyproterone acetate.	Approved, Investigational
Dabigatran etexilate	The serum concentration of Simvastatin can be increased when it is combined with Dabigatran etexilate.	Approved
Dabrafenib	The serum concentration of Simvastatin can be decreased when it is combined with Dabrafenib.	Approved
Daclatasvir	The serum concentration of Simvastatin can be increased when it is combined with Daclatasvir.	Approved
Dactinomycin	The serum concentration of Dactinomycin can be increased when it is combined with Simvastatin.	Approved
Danazol	The serum concentration of Simvastatin can be increased when it is combined with Danazol.	Approved
Dapagliflozin	The serum concentration of Dapagliflozin can be increased when it is combined with Simvastatin.	Approved
Daptomycin	The risk or severity of adverse effects can be increased when Simvastatin is combined with Daptomycin.	Approved, Investigational
Darexaban	The serum concentration of Simvastatin can be increased when it is combined with Ym150.	Investigational
Darifenacin	The metabolism of Simvastatin can be decreased when combined with Darifenacin.	Approved, Investigational
Darunavir	The serum concentration of Simvastatin can be increased when it is combined with Darunavir.	Approved
Dasatinib	The serum concentration of Simvastatin can be increased when it is combined with Dasatinib.	Approved, Investigational
Daunorubicin	The serum concentration of Daunorubicin can be increased when it is combined with Simvastatin.	Approved
Debrisoquin	The serum concentration of Debrisoquin can be increased when it is combined with Simvastatin.	Approved
Deferasirox	The serum concentration of Simvastatin can be decreased when it is combined with Deferasirox.	Approved, Investigational
Delavirdine	The metabolism of Simvastatin can be decreased when combined with Delavirdine.	Approved
Desipramine	The metabolism of Simvastatin can be decreased when combined with Desipramine.	Approved
Dexamethasone	The serum concentration of Simvastatin can be decreased when it is combined with Dexamethasone.	Approved, Investigational, Vet Approved
Diazepam	The serum concentration of Diazepam can be increased when it is combined with Simvastatin.	Approved, Illicit, Vet Approved
Dicoumarol	Simvastatin may increase the anticoagulant activities of Dicoumarol.	Approved
Diethylstilbestrol	The serum concentration of Diethylstilbestrol can be increased when it is combined with Simvastatin.	Approved
Digitoxin	The serum concentration of Digitoxin can be increased when it is combined with Simvastatin.	Approved
Digoxin	The serum concentration of Digoxin can be increased when it is combined with Simvastatin.	Approved
Dihydroergotamine	The metabolism of Simvastatin can be decreased when combined with Dihydroergotamine.	Approved
Dihydrotestosterone	The serum concentration of Dihydrotestosterone can be increased when it is combined with Simvastatin.	Illicit
Diltiazem	The serum concentration of Diltiazem can be increased when it is combined with Simvastatin.	Approved
Diphenhydramine	The metabolism of Simvastatin can be decreased when combined with Diphenhydramine.	Approved
Dipyridamole	The serum concentration of Dipyridamole can be increased when it is combined with Simvastatin.	Approved
Docetaxel	The serum concentration of Docetaxel can be increased when it is combined with Simvastatin.	Approved, Investigational
Domperidone	The serum concentration of Domperidone can be increased when it is combined with Simvastatin.	Approved, Investigational, Vet Approved
Doxorubicin	The serum concentration of Doxorubicin can be increased when it is combined with Simvastatin.	Approved, Investigational
Doxycycline	The metabolism of Simvastatin can be decreased when combined with Doxycycline.	Approved, Investigational, Vet Approved
Dronedarone	The serum concentration of Simvastatin can be increased when it is combined with Dronedarone.	Approved
Duloxetine	The metabolism of Simvastatin can be decreased when combined with Duloxetine.	Approved
Ecabet	The serum concentration of Simvastatin can be increased when it is combined with Ecabet.	Approved, Investigational
Edoxaban	The serum concentration of Simvastatin can be increased when it is combined with Edoxaban.	Approved
Efavirenz	The serum concentration of Simvastatin can be decreased when it is combined with Efavirenz.	Approved, Investigational
Elafin	The serum concentration of Simvastatin can be increased when it is combined with Elafin.	Investigational
Eletriptan	The serum concentration of Eletriptan can be increased when it is combined with Simvastatin.	Approved, Investigational
Eliglustat	The metabolism of Simvastatin can be decreased when combined with Eliglustat.	Approved
Eltrombopag	The serum concentration of Simvastatin can be increased when it is combined with Eltrombopag.	Approved
Enalapril	The serum concentration of Simvastatin can be increased when it is combined with Enalapril.	Approved, Vet Approved
Enalaprilat	The serum concentration of Simvastatin can be increased when it is combined with Enalaprilat.	Approved
Enalkiren	The serum concentration of Simvastatin can be increased when it is combined with Enalkiren.	Experimental
Enzalutamide	The serum concentration of Simvastatin can be decreased when it is combined with Enzalutamide.	Approved
Epinastine	The serum concentration of Epinastine can be increased when it is combined with Simvastatin.	Approved, Investigational
Erlotinib	The serum concentration of Erlotinib can be increased when it is combined with Simvastatin.	Approved, Investigational
Erythromycin	The serum concentration of Simvastatin can be increased when it is combined with Erythromycin.	Approved, Vet Approved
Erythromycin	The metabolism of Simvastatin can be decreased when combined with Erythromycin.	Approved, Vet Approved
Eslicarbazepine acetate	The serum concentration of Simvastatin can be decreased when it is combined with Eslicarbazepine acetate.	Approved
Estradiol	The serum concentration of Estradiol can be increased when it is combined with Simvastatin.	Approved, Investigational, Vet Approved
Estriol	The serum concentration of Estriol can be increased when it is combined with Simvastatin.	Approved, Vet Approved
Estrone	The serum concentration of Estrone can be increased when it is combined with Simvastatin.	Approved
Ethinyl Estradiol	The serum concentration of Ethinyl Estradiol can be increased when it is combined with Simvastatin.	Approved
Ethyl biscoumacetate	Simvastatin may increase the anticoagulant activities of Ethyl biscoumacetate.	Withdrawn
Etoposide	The serum concentration of Etoposide can be increased when it is combined with Simvastatin.	Approved
Etravirine	The serum concentration of Simvastatin can be decreased when it is combined with Etravirine.	Approved
Everolimus	The serum concentration of Everolimus can be increased when it is combined with Simvastatin.	Approved
Ezetimibe	The serum concentration of Ezetimibe can be increased when it is combined with Simvastatin.	Approved
Faldaprevir	The serum concentration of Simvastatin can be increased when it is combined with Bi201335.	Investigational
Felodipine	The metabolism of Simvastatin can be decreased when combined with Felodipine.	Approved, Investigational
Fenofibrate	The risk or severity of adverse effects can be increased when Fenofibrate is combined with Simvastatin.	Approved
Fesoterodine	The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Simvastatin.	Approved
Fexofenadine	The serum concentration of Fexofenadine can be increased when it is combined with Simvastatin.	Approved
Fidaxomicin	The serum concentration of Fidaxomicin can be increased when it is combined with Simvastatin.	Approved
Fluconazole	The serum concentration of Simvastatin can be increased when it is combined with Fluconazole.	Approved
Fluindione	Simvastatin may increase the anticoagulant activities of Fluindione.	Investigational
Fluoxetine	The metabolism of Simvastatin can be decreased when combined with Fluoxetine.	Approved, Vet Approved
Fluticasone furoate	The serum concentration of Fluticasone furoate can be increased when it is combined with Simvastatin.	Approved
Fluvoxamine	The metabolism of Simvastatin can be decreased when combined with Fluvoxamine.	Approved, Investigational
Fosamprenavir	The serum concentration of Simvastatin can be increased when it is combined with Fosamprenavir.	Approved
Fosaprepitant	The serum concentration of Simvastatin can be increased when it is combined with Fosaprepitant.	Approved
Fosinopril	The serum concentration of Simvastatin can be increased when it is combined with Fosinopril.	Approved
Fosphenytoin	The serum concentration of Simvastatin can be decreased when it is combined with Fosphenytoin.	Approved
Fusidic Acid	The serum concentration of Simvastatin can be increased when it is combined with Fusidic Acid.	Approved
Gabexate	The serum concentration of Simvastatin can be increased when it is combined with Gabexate.	Investigational
Gefitinib	The serum concentration of Gefitinib can be increased when it is combined with Simvastatin.	Approved, Investigational
Geldanamycin	The serum concentration of Simvastatin can be increased when it is combined with Geldanamycin.	Experimental
Gemcitabine	The serum concentration of Gemcitabine can be increased when it is combined with Simvastatin.	Approved
Gemfibrozil	Gemfibrozil may increase the myopathic rhabdomyolysis activities of Simvastatin.	Approved
GM6001	The serum concentration of Simvastatin can be increased when it is combined with GM6001.	Experimental
Grazoprevir	The serum concentration of Grazoprevir can be increased when it is combined with Simvastatin.	Approved
Grepafloxacin	The serum concentration of Grepafloxacin can be increased when it is combined with Simvastatin.	Withdrawn
Haloperidol	The serum concentration of Haloperidol can be increased when it is combined with Simvastatin.	Approved
Hydrocortisone	The serum concentration of Hydrocortisone can be increased when it is combined with Simvastatin.	Approved, Vet Approved
Ibuprofen	The serum concentration of Ibuprofen can be increased when it is combined with Simvastatin.	Approved
Idelalisib	The serum concentration of Simvastatin can be increased when it is combined with Idelalisib.	Approved
Imatinib	The metabolism of Simvastatin can be decreased when combined with Imatinib.	Approved
Imidapril	The serum concentration of Simvastatin can be increased when it is combined with Imidapril.	Investigational
Imipramine	The serum concentration of Imipramine can be increased when it is combined with Simvastatin.	Approved
Indacaterol	The serum concentration of Indacaterol can be increased when it is combined with Simvastatin.	Approved
Indinavir	The serum concentration of Simvastatin can be increased when it is combined with Indinavir.	Approved
Indomethacin	The serum concentration of Indomethacin can be increased when it is combined with Simvastatin.	Approved, Investigational
Irbesartan	The metabolism of Simvastatin can be decreased when combined with Irbesartan.	Approved, Investigational
Irinotecan	The serum concentration of Irinotecan can be increased when it is combined with Simvastatin.	Approved, Investigational
Isavuconazonium	The metabolism of Simvastatin can be decreased when combined with Isavuconazonium.	Approved, Investigational
Isoflurophate	The serum concentration of Simvastatin can be increased when it is combined with Isoflurophate.	Approved, Withdrawn
Isoniazid	The metabolism of Simvastatin can be decreased when combined with Isoniazid.	Approved
Isradipine	The metabolism of Simvastatin can be decreased when combined with Isradipine.	Approved
Itraconazole	The serum concentration of Simvastatin can be increased when it is combined with Itraconazole.	Approved, Investigational
Ivacaftor	The serum concentration of Simvastatin can be increased when it is combined with Ivacaftor.	Approved
Ivermectin	The serum concentration of Ivermectin can be increased when it is combined with Simvastatin.	Approved, Vet Approved
Ixazomib	The serum concentration of Simvastatin can be increased when it is combined with Ixazomib.	Approved
Ketazolam	The serum concentration of Ketazolam can be increased when it is combined with Simvastatin.	Approved
Ketoconazole	The serum concentration of Simvastatin can be increased when it is combined with Ketoconazole.	Approved, Investigational
Lamivudine	The serum concentration of Lamivudine can be increased when it is combined with Simvastatin.	Approved, Investigational
Lamotrigine	The serum concentration of Lamotrigine can be increased when it is combined with Simvastatin.	Approved, Investigational
Lansoprazole	The serum concentration of Lansoprazole can be increased when it is combined with Simvastatin.	Approved, Investigational
Lanthanum carbonate	The serum concentration of Lanthanum carbonate can be decreased when it is combined with Simvastatin.	Approved
Lapatinib	The metabolism of Simvastatin can be decreased when combined with Lapatinib.	Approved, Investigational
Ledipasvir	The serum concentration of Ledipasvir can be increased when it is combined with Simvastatin.	Approved
Lenalidomide	The serum concentration of Lenalidomide can be increased when it is combined with Simvastatin.	Approved
Lenvatinib	The serum concentration of Lenvatinib can be increased when it is combined with Simvastatin.	Approved
Lepirudin	The serum concentration of Simvastatin can be increased when it is combined with Lepirudin.	Approved
Lercanidipine	The serum concentration of Simvastatin can be increased when it is combined with Lercanidipine.	Approved, Investigational
Levetiracetam	The serum concentration of Levetiracetam can be increased when it is combined with Simvastatin.	Approved, Investigational
Levofloxacin	The serum concentration of Levofloxacin can be increased when it is combined with Simvastatin.	Approved, Investigational
Levomilnacipran	The serum concentration of Levomilnacipran can be increased when it is combined with Simvastatin.	Approved
Linagliptin	The serum concentration of Simvastatin can be increased when it is combined with Linagliptin.	Approved
Lisinopril	The serum concentration of Simvastatin can be increased when it is combined with Lisinopril.	Approved, Investigational
Lomitapide	The serum concentration of Simvastatin can be increased when it is combined with Lomitapide.	Approved
Loperamide	The serum concentration of Loperamide can be increased when it is combined with Simvastatin.	Approved
Lopinavir	The serum concentration of Simvastatin can be increased when it is combined with Lopinavir.	Approved
Lorcaserin	The metabolism of Simvastatin can be decreased when combined with Lorcaserin.	Approved
Losartan	The serum concentration of Losartan can be increased when it is combined with Simvastatin.	Approved
Lovastatin	The metabolism of Simvastatin can be decreased when combined with Lovastatin.	Approved, Investigational
Luliconazole	The serum concentration of Simvastatin can be increased when it is combined with Luliconazole.	Approved
Lumacaftor	The serum concentration of Simvastatin can be increased when it is combined with Lumacaftor.	Approved
Lumefantrine	The metabolism of Simvastatin can be decreased when combined with Lumefantrine.	Approved
Magaldrate	The serum concentration of Simvastatin can be decreased when it is combined with Magaldrate.	Withdrawn
Magnesium carbonate	The serum concentration of Simvastatin can be decreased when it is combined with Magnesium carbonate.	Approved
Magnesium Hydroxide	The serum concentration of Simvastatin can be decreased when it is combined with Magnesium hydroxide.	Approved
Magnesium oxide	The serum concentration of Simvastatin can be decreased when it is combined with Magnesium oxide.	Approved
Magnesium Trisilicate	The serum concentration of Simvastatin can be decreased when it is combined with Magnesium Trisilicate.	Approved
Mannitol	The serum concentration of Mannitol can be increased when it is combined with Simvastatin.	Approved, Investigational
Methadone	The metabolism of Simvastatin can be decreased when combined with Methadone.	Approved
Methotrexate	The serum concentration of Methotrexate can be increased when it is combined with Simvastatin.	Approved
Methotrimeprazine	The metabolism of Simvastatin can be decreased when combined with Methotrimeprazine.	Approved
Methylprednisolone	The serum concentration of Methylprednisolone can be increased when it is combined with Simvastatin.	Approved, Vet Approved
Metoprolol	The serum concentration of Metoprolol can be increased when it is combined with Simvastatin.	Approved, Investigational
Midazolam	The serum concentration of Midazolam can be increased when it is combined with Simvastatin.	Approved, Illicit
Mifepristone	The serum concentration of Simvastatin can be increased when it is combined with Mifepristone.	Approved, Investigational
Mirabegron	The serum concentration of Mirabegron can be increased when it is combined with Simvastatin.	Approved
Mitotane	The serum concentration of Simvastatin can be decreased when it is combined with Mitotane.	Approved
Mitoxantrone	The serum concentration of Mitoxantrone can be increased when it is combined with Simvastatin.	Approved, Investigational
Modafinil	The serum concentration of Simvastatin can be decreased when it is combined with Modafinil.	Approved, Investigational
Moexipril	The serum concentration of Simvastatin can be increased when it is combined with Moexipril.	Approved
Morphine	The serum concentration of Morphine can be increased when it is combined with Simvastatin.	Approved, Investigational
Mycophenolate mofetil	The serum concentration of Mycophenolate mofetil can be increased when it is combined with Simvastatin.	Approved, Investigational
N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-Proline	The serum concentration of Simvastatin can be increased when it is combined with N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-Proline.	Experimental
Nadolol	The serum concentration of Nadolol can be increased when it is combined with Simvastatin.	Approved
Nafamostat	The serum concentration of Simvastatin can be increased when it is combined with Nafamostat.	Approved, Investigational
Nafcillin	The serum concentration of Simvastatin can be decreased when it is combined with Nafcillin.	Approved
Naloxegol	The serum concentration of Naloxegol can be increased when it is combined with Simvastatin.	Approved
Naloxone	The serum concentration of Naloxone can be increased when it is combined with Simvastatin.	Approved, Vet Approved
NCX 4016	The serum concentration of Simvastatin can be increased when it is combined with NCX 4016.	Investigational
Nefazodone	The serum concentration of Simvastatin can be increased when it is combined with Nefazodone.	Approved, Withdrawn
Nelfinavir	The serum concentration of Simvastatin can be increased when it is combined with Nelfinavir.	Approved
Netupitant	The serum concentration of Simvastatin can be increased when it is combined with Netupitant.	Approved
Nevirapine	The metabolism of Simvastatin can be increased when combined with Nevirapine.	Approved
Niacin	The risk or severity of adverse effects can be increased when Niacin is combined with Simvastatin.	Approved, Investigational, Nutraceutical
Nicardipine	The serum concentration of Nicardipine can be increased when it is combined with Simvastatin.	Approved
Nicotinamide	The risk or severity of adverse effects can be increased when Nicotinamide is combined with Simvastatin.	Approved
Nifedipine	The serum concentration of Nifedipine can be increased when it is combined with Simvastatin.	Approved
Nilotinib	The metabolism of Simvastatin can be decreased when combined with Nilotinib.	Approved, Investigational
Nintedanib	The serum concentration of Nintedanib can be increased when it is combined with Simvastatin.	Approved
Nitroaspirin	The serum concentration of Simvastatin can be increased when it is combined with Nitroaspirin.	Investigational
Nizatidine	The serum concentration of Nizatidine can be increased when it is combined with Simvastatin.	Approved
Olanzapine	The serum concentration of Olanzapine can be increased when it is combined with Simvastatin.	Approved, Investigational
Olaparib	The metabolism of Simvastatin can be decreased when combined with Olaparib.	Approved
Omapatrilat	The serum concentration of Simvastatin can be increased when it is combined with Omapatrilat.	Investigational
Ombitasvir	The serum concentration of Ombitasvir can be increased when it is combined with Simvastatin.	Approved
Osimertinib	The serum concentration of Simvastatin can be increased when it is combined with Osimertinib.	Approved
Paclitaxel	The serum concentration of Paclitaxel can be increased when it is combined with Simvastatin.	Approved, Vet Approved
Palbociclib	The serum concentration of Simvastatin can be increased when it is combined with Palbociclib.	Approved
Panobinostat	The serum concentration of Simvastatin can be increased when it is combined with Panobinostat.	Approved, Investigational
Paroxetine	The metabolism of Simvastatin can be decreased when combined with Paroxetine.	Approved, Investigational
Pazopanib	The serum concentration of Pazopanib can be increased when it is combined with Simvastatin.	Approved
Peginterferon alfa-2b	The serum concentration of Simvastatin can be decreased when it is combined with Peginterferon alfa-2b.	Approved
Pentobarbital	The metabolism of Simvastatin can be increased when combined with Pentobarbital.	Approved, Vet Approved
Perindopril	The serum concentration of Simvastatin can be increased when it is combined with Perindopril.	Approved
Phenindione	Simvastatin may increase the anticoagulant activities of Phenindione.	Approved
Phenobarbital	The metabolism of Simvastatin can be increased when combined with Phenobarbital.	Approved
Phenprocoumon	Simvastatin may increase the anticoagulant activities of Phenprocoumon.	Approved
Phenytoin	The serum concentration of Simvastatin can be decreased when it is combined with Phenytoin.	Approved, Vet Approved
Phosphoramidon	The serum concentration of Simvastatin can be increased when it is combined with Phosphoramidon.	Experimental
Pioglitazone	The metabolism of Simvastatin can be decreased when combined with Pioglitazone.	Approved, Investigational
Pitavastatin	The serum concentration of Pitavastatin can be increased when it is combined with Simvastatin.	Approved
Pomalidomide	The serum concentration of Pomalidomide can be increased when it is combined with Simvastatin.	Approved
Ponatinib	The serum concentration of Ponatinib can be increased when it is combined with Simvastatin.	Approved
Posaconazole	The serum concentration of Simvastatin can be increased when it is combined with Posaconazole.	Approved, Investigational, Vet Approved
Pravastatin	The serum concentration of Pravastatin can be increased when it is combined with Simvastatin.	Approved
Prazosin	The serum concentration of Prazosin can be increased when it is combined with Simvastatin.	Approved
Prednisolone	The serum concentration of Prednisolone can be increased when it is combined with Simvastatin.	Approved, Vet Approved
Prednisone	The serum concentration of Prednisone can be increased when it is combined with Simvastatin.	Approved, Vet Approved
Primidone	The metabolism of Simvastatin can be increased when combined with Primidone.	Approved, Vet Approved
Prinomastat	The serum concentration of Simvastatin can be increased when it is combined with Prinomastat.	Investigational
Progesterone	The serum concentration of Progesterone can be increased when it is combined with Simvastatin.	Approved, Vet Approved
Promazine	The metabolism of Simvastatin can be decreased when combined with Promazine.	Approved, Vet Approved
Propranolol	The serum concentration of Propranolol can be increased when it is combined with Simvastatin.	Approved, Investigational
Prucalopride	The serum concentration of Prucalopride can be increased when it is combined with Simvastatin.	Approved
Quetiapine	The serum concentration of Quetiapine can be increased when it is combined with Simvastatin.	Approved
Quinapril	The serum concentration of Simvastatin can be increased when it is combined with Quinapril.	Approved, Investigational
Quinidine	The metabolism of Simvastatin can be decreased when combined with Quinidine.	Approved
Quinine	The serum concentration of Simvastatin can be increased when it is combined with Quinine.	Approved
Rabeprazole	The metabolism of Simvastatin can be decreased when combined with Rabeprazole.	Approved, Investigational
Racecadotril	The serum concentration of Simvastatin can be increased when it is combined with Racecadotril.	Investigational
Raltegravir	Raltegravir may increase the myopathic rhabdomyolysis activities of Simvastatin.	Approved
Ramipril	The serum concentration of Simvastatin can be increased when it is combined with Ramipril.	Approved
Ranitidine	The serum concentration of Ranitidine can be increased when it is combined with Simvastatin.	Approved
Ranolazine	The serum concentration of Simvastatin can be increased when it is combined with Ranolazine.	Approved, Investigational
Remikiren	The serum concentration of Simvastatin can be increased when it is combined with Remikiren.	Approved
Reserpine	The serum concentration of Reserpine can be increased when it is combined with Simvastatin.	Approved
Rifabutin	The metabolism of Simvastatin can be increased when combined with Rifabutin.	Approved
Rifampicin	The metabolism of Simvastatin can be increased when combined with Rifampicin.	Approved
Rifapentine	The metabolism of Simvastatin can be increased when combined with Rifapentine.	Approved
Rifaximin	The serum concentration of Rifaximin can be increased when it is combined with Simvastatin.	Approved, Investigational
Risperidone	The serum concentration of Risperidone can be increased when it is combined with Simvastatin.	Approved, Investigational
Ritonavir	The serum concentration of Simvastatin can be increased when it is combined with Ritonavir.	Approved, Investigational
Rivaroxaban	The serum concentration of Simvastatin can be increased when it is combined with Rivaroxaban.	Approved
Rolapitant	The metabolism of Simvastatin can be decreased when combined with Rolapitant.	Approved
Romidepsin	The serum concentration of Romidepsin can be increased when it is combined with Simvastatin.	Approved, Investigational
Ropinirole	The metabolism of Simvastatin can be decreased when combined with Ropinirole.	Approved, Investigational
Rosiglitazone	The metabolism of Simvastatin can be decreased when combined with Rosiglitazone.	Approved, Investigational
Salicylic acid	The serum concentration of Salicylic acid can be increased when it is combined with Simvastatin.	Approved, Vet Approved
Saquinavir	The serum concentration of Simvastatin can be increased when it is combined with Saquinavir.	Approved, Investigational
Saxagliptin	The serum concentration of Simvastatin can be increased when it is combined with Saxagliptin.	Approved
Secobarbital	The metabolism of Simvastatin can be increased when combined with Secobarbital.	Approved, Vet Approved
Selexipag	The serum concentration of Selexipag can be increased when it is combined with Simvastatin.	Approved
Sertraline	The metabolism of Simvastatin can be decreased when combined with Sertraline.	Approved
Sildenafil	The metabolism of Simvastatin can be decreased when combined with Sildenafil.	Approved, Investigational
Silodosin	The serum concentration of Silodosin can be increased when it is combined with Simvastatin.	Approved
Siltuximab	The serum concentration of Simvastatin can be decreased when it is combined with Siltuximab.	Approved
Simeprevir	The serum concentration of Simvastatin can be increased when it is combined with Simeprevir.	Approved
Sitagliptin	The serum concentration of Simvastatin can be increased when it is combined with Sitagliptin.	Approved, Investigational
Sofosbuvir	The serum concentration of Sofosbuvir can be increased when it is combined with Simvastatin.	Approved
Sorafenib	The serum concentration of Sorafenib can be increased when it is combined with Simvastatin.	Approved, Investigational
Sparfloxacin	The serum concentration of Sparfloxacin can be increased when it is combined with Simvastatin.	Approved
Sphingosine	The serum concentration of Sphingosine can be increased when it is combined with Simvastatin.	Experimental
Spirapril	The serum concentration of Simvastatin can be increased when it is combined with Spirapril.	Approved
St. John's Wort	The metabolism of Simvastatin can be increased when combined with St. John's Wort.	Nutraceutical
Stiripentol	The serum concentration of Simvastatin can be increased when it is combined with Stiripentol.	Approved
Sulfamethoxazole	The metabolism of Simvastatin can be decreased when combined with Sulfamethoxazole.	Approved
Sulfisoxazole	The metabolism of Simvastatin can be decreased when combined with Sulfisoxazole.	Approved, Vet Approved
Tacrolimus	The serum concentration of Tacrolimus can be increased when it is combined with Simvastatin.	Approved, Investigational
Tamoxifen	The serum concentration of Tamoxifen can be increased when it is combined with Simvastatin.	Approved
Taurocholic Acid	The serum concentration of Taurocholic Acid can be increased when it is combined with Simvastatin.	Experimental
Technetium Tc-99m sestamibi	The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Simvastatin.	Approved
Telaprevir	The serum concentration of Simvastatin can be increased when it is combined with Telaprevir.	Withdrawn
Telithromycin	The serum concentration of Simvastatin can be increased when it is combined with Telithromycin.	Approved
Temocapril	The serum concentration of Simvastatin can be increased when it is combined with Temocapril.	Experimental, Investigational
Temsirolimus	The serum concentration of Temsirolimus can be increased when it is combined with Simvastatin.	Approved
Terbinafine	The metabolism of Simvastatin can be decreased when combined with Terbinafine.	Approved, Investigational, Vet Approved
Teriflunomide	The serum concentration of Simvastatin can be increased when it is combined with Teriflunomide.	Approved
Thioridazine	The serum concentration of Thioridazine can be increased when it is combined with Simvastatin.	Withdrawn
Thiorphan	The serum concentration of Simvastatin can be increased when it is combined with Thiorphan.	Experimental
Ticagrelor	The serum concentration of Simvastatin can be increased when it is combined with Ticagrelor.	Approved
Ticlopidine	The metabolism of Simvastatin can be decreased when combined with Ticlopidine.	Approved
Timolol	The serum concentration of Timolol can be increased when it is combined with Simvastatin.	Approved
Tipranavir	The serum concentration of Simvastatin can be increased when it is combined with Tipranavir.	Approved, Investigational
Tocilizumab	The serum concentration of Simvastatin can be decreased when it is combined with Tocilizumab.	Approved
Tolvaptan	The serum concentration of Tolvaptan can be increased when it is combined with Simvastatin.	Approved
Topotecan	The serum concentration of Topotecan can be increased when it is combined with Simvastatin.	Approved, Investigational
Toremifene	The serum concentration of Toremifene can be increased when it is combined with Simvastatin.	Approved, Investigational
Trabectedin	Simvastatin may increase the myopathic rhabdomyolysis activities of Trabectedin.	Approved, Investigational
Trandolapril	The serum concentration of Simvastatin can be increased when it is combined with Trandolapril.	Approved
Tranylcypromine	The metabolism of Simvastatin can be decreased when combined with Tranylcypromine.	Approved
Trastuzumab emtansine	The serum concentration of Trastuzumab emtansine can be increased when it is combined with Simvastatin.	Approved
Trimethoprim	The metabolism of Simvastatin can be decreased when combined with Trimethoprim.	Approved, Vet Approved
Ubenimex	The serum concentration of Simvastatin can be increased when it is combined with Ubenimex.	Experimental
Ulinastatin	The serum concentration of Simvastatin can be increased when it is combined with Ulinastatin.	Investigational
Ulipristal	The serum concentration of Ulipristal can be increased when it is combined with Simvastatin.	Approved
Umeclidinium	The serum concentration of Umeclidinium can be increased when it is combined with Simvastatin.	Approved
Vecuronium	The serum concentration of Vecuronium can be increased when it is combined with Simvastatin.	Approved
Venetoclax	The serum concentration of Venetoclax can be increased when it is combined with Simvastatin.	Approved
Venlafaxine	The metabolism of Simvastatin can be decreased when combined with Venlafaxine.	Approved
Verapamil	The serum concentration of Simvastatin can be increased when it is combined with Verapamil.	Approved
Vildagliptin	The serum concentration of Simvastatin can be increased when it is combined with Vildagliptin.	Approved, Investigational
Vinblastine	The serum concentration of Vinblastine can be increased when it is combined with Simvastatin.	Approved
Vincristine	The serum concentration of Vincristine can be increased when it is combined with Simvastatin.	Approved, Investigational
Vismodegib	The serum concentration of Vismodegib can be increased when it is combined with Simvastatin.	Approved
Voriconazole	The serum concentration of Simvastatin can be increased when it is combined with Voriconazole.	Approved, Investigational
Warfarin	Simvastatin may increase the anticoagulant activities of Warfarin.	Approved
Ximelagatran	The serum concentration of Simvastatin can be increased when it is combined with Ximelagatran.	Approved, Investigational, Withdrawn
Zidovudine	The serum concentration of Zidovudine can be increased when it is combined with Simvastatin.	Approved
Ziprasidone	The metabolism of Simvastatin can be decreased when combined with Ziprasidone.	Approved

Food Interactions

Avoid alcohol.
Avoid drastic changes in dietary habit.
Avoid taking with grapefruit juice.

References

Synthesis Reference

Shieh-Shung J. Chen, Byron H. Arison, "Process for the preparation of 3-keto, 5-hydroxy simvastatin analogs." U.S. Patent US4965200, issued April, 1981.

US4965200

General References

Wolozin B, Wang SW, Li NC, Lee A, Lee TA, Kazis LE: Simvastatin is associated with a reduced incidence of dementia and Parkinson's disease. BMC Med. 2007 Jul 19;5:20. [PubMed:17640385 ]

External Links

Resource	Link
Human Metabolome Database (HMDB)	HMDB05007
KEGG Drug	D00434
ChemSpider	49179
BindingDB	50139181
ChEBI	9150
ChEMBL	CHEMBL1064
Therapeutic Targets Database	DAP001519
PharmGKB	PA451363
HET	SIM
Drug Product Database	1221
RxList	http://www.rxlist.com/cgi/generic/simva.htm
Drugs.com	http://www.drugs.com/simvastatin.html
PDRhealth	http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/zoc1500.shtml
Wikipedia	Simvastatin

ATC Codes

C10BX04 — Simvastatin, acetylsalicylic acid and ramipril

C10BA02 — Simvastatin and ezetimibe

A10BH51 — Sitagliptin and simvastatin

C10BA04 — Simvastatin and fenofibrate

C10AA01 — Simvastatin

C10BX01 — Simvastatin and acetylsalicylic acid

AHFS Codes

24:06.08

PDB Entries

Not Available

FDA label

Download (102 KB)

MSDS

Download (87.5 KB)

Clinical Trials

Phase	Status	Purpose	Conditions	Count
0	Completed	Basic Science	Heart Failure, Unspecified	1
0	Completed	Basic Science	Peripheral Arterial Disease (PAD)	1
0	Completed	Treatment	Cavernous Angioma, Familial / Cerebral Cavernous Hemangioma / Cerebral Cavernous Malformations	1
0	Enrolling by Invitation	Prevention	Atherosclerosis	1
0	Recruiting	Supportive Care	Cancers / Tumors, Solid	1
0	Recruiting	Treatment	Malignant Neoplasm of Prostate	1
0	Unknown Status	Basic Science	Heart Failure, Unspecified / Hepatic Failure / Renal Failure / Respiratory Failure / Transplantations	1
0	Withdrawn	Treatment	Recurrent Plasma Cell Myeloma / Refractory Plasma Cell Myeloma	1
1	Active Not Recruiting	Basic Science	Healthy Participants	1
1	Active Not Recruiting	Treatment	Healthy Volunteers	1
1	Active Not Recruiting	Treatment	Non-Small-Cell Lung Carcinoma (NSCLC)	1
1	Completed	Not Available	Healthy Volunteers	4
1	Completed	Not Available	Human Immunodeficiency Virus (HIV) Infections	1
1	Completed	Not Available	Pain, Chronic	1
1	Completed	Not Available	Type 2 Diabetes Mellitus	2
1	Completed	Basic Science	Dyslipidemias	1
1	Completed	Basic Science	Healthy Volunteers	5
1	Completed	Basic Science	Human Volunteers	1
1	Completed	Basic Science	Hypercholesterolaemia	1
1	Completed	Basic Science	Rheumatoid Arthritis	1
1	Completed	Basic Science	Type 2 Diabetes Mellitus	1
1	Completed	Health Services Research	Rheumatoid Arthritis	1
1	Completed	Other	Type 2 Diabetes Mellitus	2
1	Completed	Treatment	Acute Kidney Injury (AKI)	1
1	Completed	Treatment	Alopecia Areata (AA)	1
1	Completed	Treatment	Cholesterol, LDL / Hypercholesterolaemia	1
1	Completed	Treatment	Chronic Lymphocytic Leukaemia (CLL)	1
1	Completed	Treatment	Dyslipidemias	1
1	Completed	Treatment	Epilepsies	1
1	Completed	Treatment	HIV Seronegativity / Human Immunodeficiency Virus (HIV) Infections / Lipodystrophies	1
1	Completed	Treatment	Healthy Participants	1
1	Completed	Treatment	Healthy Volunteers	8
1	Completed	Treatment	Human Immunodeficiency Virus (HIV) Infections	1
1	Completed	Treatment	Hypercholesterolaemia / Hyperlipidemias	1
1	Completed	Treatment	Hypercholesterolemia, Dyslipidemia	1
1	Completed	Treatment	Hypertriglyceridemias	1
1	Completed	Treatment	Rheumatoid Arthritis	1
1	Completed	Treatment	Sleep disorders and disturbances	1
1	Completed	Treatment	Systemic Lupus Erythematosus (SLE)	1
1	Completed	Treatment	Type 2 Diabetes Mellitus	2
1	Completed	Treatment	Viral Hepatitis B	1
1	Not Yet Recruiting	Treatment	Malignant Neoplasm of Stomach	1
1	Recruiting	Not Available	Healthy Volunteers	1
1	Recruiting	Treatment	Clear Cell Sarcoma of Soft Tissue / Ewings Sarcoma / Germ Cell Tumors / Hepatoblastomas / Neuroblastomas / Non-rhabdomyosarcoma Soft Tissue Sarcomas / Renal Cell Adenocarcinoma / Retinoblastoma / Rhabdoid Tumors / Rhabdomyosarcomas / Sarcoma, Osteogenic / Wilms' tumor	1
1	Recruiting	Treatment	Drug Distribution	1
1	Recruiting	Treatment	Dyslipidemias / Peripheral Artery Disease (PAD)	1
1	Recruiting	Treatment	Type 2 Diabetes Mellitus	1
1	Terminated	Basic Science	Healthy Volunteers	1
1	Terminated	Diagnostic	Gluten Enteropathy	1
1	Terminated	Prevention	Acute Coronary Syndromes (ACS) / Coronary Artery Disease / Depressive State	1
1	Unknown Status	Treatment	Chronic Obstructive Pulmonary Disease (COPD) / Inflammatory Reaction	1
1	Unknown Status	Treatment	Psychosis Not Otherwise Specified / Schizoaffective Disorders / Schizophrenic Disorders / Schizophreniform Disorder	1
1	Unknown Status	Treatment	Pulmonary Hypertension (PH)	1
1, 2	Completed	Treatment	Delayed Vasospasm / Subarachnoid Hemorrhage	1
1, 2	Completed	Treatment	Multiple Myeloma (MM)	1
1, 2	Completed	Treatment	Pulmonary Hypertension (PH)	1
1, 2	Completed	Treatment	Sickle Cell Disorders	2
1, 2	Completed	Treatment	Subarachnoid Hemorrhage	1
1, 2	Recruiting	Not Available	Coronary Microvascular Disease	1
1, 2	Recruiting	Treatment	Lymphangioleiomyomatosis / Tuberous Sclerosis Complex (TSC)	1
1, 2	Terminated	Supportive Care	Choroideremia	1
1, 2	Withdrawn	Treatment	Cystic Fibrosis (CF) / Systemic Inflammation	1
2	Active Not Recruiting	Prevention	Alzheimer's Disease (AD)	1
2	Active Not Recruiting	Treatment	Alzheimer's Disease (AD)	1
2	Completed	Basic Science	Oxidative Stress	1
2	Completed	Diagnostic	Healthy Volunteers	1
2	Completed	Diagnostic	Type 2 Diabetes Mellitus	1
2	Completed	Prevention	Alzheimer's Disease (AD)	1
2	Completed	Prevention	Cancer, Breast	2
2	Completed	Prevention	Migraines	1
2	Completed	Prevention	Nonvalvular Atrial Fibrillation	1
2	Completed	Treatment	Cancer, Breast	1
2	Completed	Treatment	Carotid Atherosclerosis	1
2	Completed	Treatment	Colorectal Cancers / Metastasis	1
2	Completed	Treatment	Diabetes, Diabetes Mellitus Type 1	1
2	Completed	Treatment	Diabetes, Diabetes Mellitus Type 1 / Dyslipidemias	1
2	Completed	Treatment	Diabetic Polyneuropathy / Oxidative Stress	1
2	Completed	Treatment	Dyslipidemias	2
2	Completed	Treatment	Liver Cirrhosis / Portal Hypertension	1
2	Completed	Treatment	Lung Cancer Small Cell Lung Cancer (SCLC)	1
2	Completed	Treatment	Lung Cancers	1
2	Completed	Treatment	Malignant Neoplasm of Pancreas	1
2	Completed	Treatment	Metastatic Brain Tumors	1
2	Completed	Treatment	Metastatic Colorectal Cancers	1
2	Completed	Treatment	Multiple Myeloma (MM)	1
2	Completed	Treatment	Psychosis Not Otherwise Specified / Schizoaffective Disorders / Schizophrenic Disorders / Schizophreniform Disorder	1
2	Completed	Treatment	Secondary Progressive Multiple Sclerosis (SPMS)	1
2	Completed	Treatment	Three Wall Intrabony Defects in Chronic Periodontitis	1
2	Completed	Treatment	Vitiligo	1
2	Not Yet Recruiting	Treatment	Cirrhoses, Liver	1
2	Recruiting	Prevention	Liver Cirrhosis	1
2	Recruiting	Prevention	Bone destruction / Spinal Cord Injuries (SCI)	1
2	Recruiting	Treatment	Acute Pancreatitis (AP) / Pancreatitis, Chronic / Recurrent Disease	1
2	Recruiting	Treatment	Adenocarcinoma of Rectum	1
2	Recruiting	Treatment	Bladder Cancers	1
2	Recruiting	Treatment	Cancer, Breast / Stage I Breast Carcinoma / Stage II Breast Cancer / Stage III Breast Cancer	1
2	Recruiting	Treatment	Cessation, Smoking	1
2	Recruiting	Treatment	Colorectal Cancers	1
2	Recruiting	Treatment	Parkinson's Disease (PD)	1
2	Recruiting	Treatment	Severe Asthma	1
2	Terminated	Prevention	Elevated LDL Cholesterol	2
2	Terminated	Treatment	Acute maxillary sinusitis caused by M. catarrhalis	1
2	Terminated	Treatment	Bipolar Disorder (BD)	1
2	Terminated	Treatment	Intracerebral Hemorrhage	1
2	Terminated	Treatment	Pulmonary Hypertension (PH)	1
2	Terminated	Treatment	Waldenstrom's Macroglobulinemia (WM)	1
2	Unknown Status	Treatment	Acute Myocardial Infarction (AMI)	1
2	Unknown Status	Treatment	Cancer, Breast	1
2	Unknown Status	Treatment	Colorectal Cancers	2
2	Unknown Status	Treatment	Non-Small-Cell Lung Carcinoma (NSCLC)	1
2	Unknown Status	Treatment	Sepsis	1
2	Withdrawn	Treatment	Malignant Neoplasm of Prostate	1
2	Withdrawn	Treatment	Plasma Cell Myeloma	1
2	Withdrawn	Treatment	Smoldering Multiple Myeloma (SMM)	1
2, 3	Completed	Not Available	Pre-Diabetic	1
2, 3	Completed	Diagnostic	Gluten Enteropathy	1
2, 3	Completed	Prevention	Strokes / Transient Ischaemic Attack (TIA)	1
2, 3	Completed	Prevention	Subarachnoid Hemorrhage	1
2, 3	Completed	Treatment	Chronic Periodontitis	2
2, 3	Completed	Treatment	Shock, Septic	1
2, 3	Completed	Treatment	Transplantation, Renal	1
2, 3	Recruiting	Treatment	Uveitis	1
3	Completed	Diagnostic	Cholesterol	1
3	Completed	Prevention	Atherosclerosis / Cardiovascular Disease (CVD) / Diabetes Mellitus (DM) / Heart Diseases / Hypertensive	1
3	Completed	Prevention	Atherosclerosis / Hypercholesterolaemia / Hyperlipoproteinemia Type II	1
3	Completed	Prevention	Cardiovascular Disease (CVD) / Coronary Heart Disease (CHD) / Diabetes Mellitus (DM) / Peripheral Arterial Disease (PAD)	1
3	Completed	Prevention	Cardiovascular Disease (CVD) / Coronary Heart Disease (CHD) / Heart Diseases / Myocardial Ischemia	1
3	Completed	Prevention	Retinopathy, Diabetic	1
3	Completed	Supportive Care	Polycystic Ovaries Syndrome	1
3	Completed	Treatment	Alzheimer's Disease (AD)	1
3	Completed	Treatment	Asthma Bronchial	2
3	Completed	Treatment	Atherosclerosis / Cardiovascular Disease (CVD)	1
3	Completed	Treatment	Atherosclerosis / Coronary Heart Disease (CHD) / Hypercholesterolaemia	1
3	Completed	Treatment	C Reactive Protein / Erectile Dysfunction (ED) / Vascular Disease Detected	1
3	Completed	Treatment	Cardiovascular Disease (CVD)	1
3	Completed	Treatment	Cardiovascular Disorder / Diabetes Mellitus (DM)	1
3	Completed	Treatment	Chronic Kidney Disease (CKD)	1
3	Completed	Treatment	Chronic Obstructive Pulmonary Disease (COPD)	2
3	Completed	Treatment	Coronary Heart Disease (CHD) / Dyslipidemias / Hypercholesterolaemia	1
3	Completed	Treatment	Coronary Heart Disease (CHD) / Dyslipidemias / Mixed hypercholesterolemia	2
3	Completed	Treatment	Coronary Heart Disease (CHD) / Hypercholesterolaemia / Type 2 Diabetes Mellitus	1
3	Completed	Treatment	Critical Illness	1
3	Completed	Treatment	Diabetic Dyslipidemia / Type 2 Diabetes Mellitus	1
3	Completed	Treatment	Dyslipidemia, Hypercholesterolemia, Hypertriglyceridemia	1
3	Completed	Treatment	Dyslipidemias	1
3	Completed	Treatment	Dyslipidemias / Hypercholesterolaemia	3
3	Completed	Treatment	Dyslipidemias / Hypercholesterolaemia / Hyperlipidemias	1
3	Completed	Treatment	Dyslipidemias / Hypercholesterolaemia / Hypertensive	1
3	Completed	Treatment	Dyslipidemias / Hypertensive	1
3	Completed	Treatment	Fredrickson Type IIa & Type IIb Dyslipidaemia	1
3	Completed	Treatment	Heterozygous Familial Hypercholesterolemia	1
3	Completed	Treatment	Hypercholesterolaemia	16
3	Completed	Treatment	Hypercholesterolaemia / Hypertension,Essential	1
3	Completed	Treatment	Hypercholesterolaemia / Hypertensive	1
3	Completed	Treatment	Hypercholesterolaemia / Metabolic Syndromes	1
3	Completed	Treatment	Hypercholesterolaemia / Myocardial Infarction (MI)	1
3	Completed	Treatment	Hypercholesterolemia, Familial / Mixed hypercholesterolemia	3
3	Completed	Treatment	Hyperlipidemias	5
3	Completed	Treatment	Hyperlipidemias / Mixed hypercholesterolemia	1
3	Completed	Treatment	Hypertensive / Type 2 Diabetes Mellitus	1
3	Completed	Treatment	Hypertriglyceridemias	2
3	Completed	Treatment	Intestinal Neoplasms / Perioperative Care	1
3	Completed	Treatment	Liver Cirrhosis / Oesophageal varices haemorrhage / Portal Hypertension / Portal Vein Thrombosis	1
3	Completed	Treatment	Liver Cirrhosis / Portal Hypertension / Varices, Esophageal	1
3	Completed	Treatment	Malignant Neoplasm of Stomach	1
3	Completed	Treatment	Relapsing Remitting Multiple Sclerosis (RRMS)	1
3	Completed	Treatment	Subarachnoid Haemorrhage	1
3	Completed	Treatment	Type 2 Diabetes Mellitus	1
3	Completed	Treatment	Mixed hypercholesterolemia	2
3	Not Yet Recruiting	Treatment	Graves Ophthalmopathy / Thyroid Associated Ophthalmopathy / Thyroid Associated Orbitopathy	1
3	Recruiting	Treatment	Endothelial Dysfunction	1
3	Recruiting	Treatment	Hypercholesterolaemia	1
3	Recruiting	Treatment	Infertilities	1
3	Recruiting	Treatment	Noonan Syndrome	1
3	Recruiting	Treatment	Psychotic Disorder NOS / Schizoaffective Disorders / Schizophrenic Disorders / Schizophreniform Disorder	1
3	Terminated	Basic Science	Atherosclerosis / Hypercholesterolaemia	1
3	Terminated	Prevention	Atherosclerosis / Cardiovascular Disease (CVD) / Cerebrovascular Accidents / Coronary Heart Disease (CHD) / Heart Diseases / Myocardial Infarction (MI)	1
3	Terminated	Treatment	Dyslipidemias / Hypercholesterolaemia / Hyperlipidemias	1
3	Terminated	Treatment	Dyslipidemias / Hypercholesterolemia, Familial	1
3	Terminated	Treatment	Dyslipidemias / Hyperlipidemias	1
3	Terminated	Treatment	Hypercholesterolaemia	2
3	Terminated	Treatment	Hypercholesterolemia, Familial / Mixed hypercholesterolemia	1
3	Terminated	Treatment	Hypertensive	1
3	Terminated	Treatment	Pneumonia	1
3	Terminated	Treatment	Pulmonary Disease, Chronic Obstructive	1
3	Terminated	Treatment	Type 2 Diabetes Mellitus	1
3	Unknown Status	Treatment	Cardiovascular Disease (CVD)	1
3	Unknown Status	Treatment	Colorectal Cancers	1
3	Unknown Status	Treatment	Community Acquired Pneumonia (CAP)	1
3	Unknown Status	Treatment	Disseminated Sclerosis / Optic Neuritis	1
3	Unknown Status	Treatment	Inflammatory Reaction	1
3	Unknown Status	Treatment	Relapsing Remitting Multiple Sclerosis (RRMS)	1
3	Unknown Status	Treatment	[X]Statin Causing Adverse Effect in Therapeutic Use	1
3	Withdrawn	Treatment	Relapsing Remitting Multiple Sclerosis (RRMS)	1
4	Active Not Recruiting	Treatment	Acute Coronary Syndromes (ACS) / Hypertriglyceridemias / Type 2 Diabetes Mellitus	1
4	Completed	Not Available	Cardiovascular Disease (CVD) / Cholesterol, LDL / Cognition / Type 2 Diabetes Mellitus	1
4	Completed	Not Available	Dyslipidemias	1
4	Completed	Basic Science	Atherosclerosis	1
4	Completed	Basic Science	Cardiovascular Disease (CVD) / Diabetes Mellitus (DM)	1
4	Completed	Diagnostic	Healthy Men	1
4	Completed	Health Services Research	Diabetes Mellitus (DM) / Dyslipidemias	1
4	Completed	Health Services Research	Peripheral Arterial Disease (PAD)	1
4	Completed	Prevention	Aging / Alzheimer's Disease (AD)	1
4	Completed	Prevention	Cardiovascular Disease (CVD)	1
4	Completed	Prevention	Cardiovascular Disease (CVD) / Coronary Heart Disease (CHD) / Hypercholesterolaemia / Hyperlipidemias	1
4	Completed	Prevention	Endothelial Dysfunction / Inflammatory Reaction / Myocardial Infarction (MI)	1
4	Completed	Prevention	Kidney Disease, Chronic	1
4	Completed	Prevention	Myocardial Infarction (MI)	1
4	Completed	Prevention	Renal Failure	1
4	Completed	Treatment	Atherosclerosis	1
4	Completed	Treatment	Atherosclerosis / Coronary Heart Disease (CHD) / Diabetes / Dyslipidemias / Strokes	1
4	Completed	Treatment	Atherosclerosis / Hypercholesterolaemia	2
4	Completed	Treatment	Cardiovascular Disease (CVD)	1
4	Completed	Treatment	Cardiovascular Disorder	1
4	Completed	Treatment	Chronic Obstructive Pulmonary Disease (COPD)	1
4	Completed	Treatment	Coronary Artery Disease	1
4	Completed	Treatment	Coronary Heart Disease (CHD)	1
4	Completed	Treatment	Coronary Heart Disease (CHD) / Hypercholesterolaemia	1
4	Completed	Treatment	Diabetes Mellitus (DM) / Impaired Renal Function	1
4	Completed	Treatment	Diastolic Dysfunction / Hypertensive	1
4	Completed	Treatment	Disseminated Sclerosis	2
4	Completed	Treatment	Dyslipidemias	1
4	Completed	Treatment	Fenofibrate/Simvastatin Comparison	1
4	Completed	Treatment	Hypercholesterolaemia	15
4	Completed	Treatment	Hypercholesterolaemia / Type 2 Diabetes Mellitus	1
4	Completed	Treatment	Hyperlipidemias	1
4	Completed	Treatment	Hypertriglycemia / Type 2 Diabetes Mellitus	1
4	Completed	Treatment	Metabolic Syndromes	3
4	Completed	Treatment	Myocardial Infarction (MI)	1
4	Completed	Treatment	Chronic, stable Angina pectoris / Non ST Segment Elevation Myocardial Infarction (NSTEMI) / Unstable Angina Pectoris	1
4	Completed	Treatment	Postprandial Lipaemia / Type 2 Diabetes Mellitus	1
4	Completed	Treatment	Schizophrenic Disorders	1
4	Completed	Treatment	Stroke, Acute	1
4	Completed	Treatment	Type 2 Diabetes Mellitus	1
4	Not Yet Recruiting	Basic Science	Healthy Volunteers	1
4	Recruiting	Basic Science	Cardiovascular Disease (CVD) / Diabetes Mellitus (DM)	1
4	Recruiting	Prevention	Hypertensive / Strokes / Transient Ischaemic Attack (TIA)	1
4	Recruiting	Prevention	Mild Cognitive Impairment (MCI)	1
4	Recruiting	Treatment	Bipolar Disorder (BD) / Cardiovascular Disease (CVD) / Major Depressive Disorder (MDD) / Psychotic Disorder NOS / Schizoaffective Disorders / Schizophrenic Disorders / Serious Mental Illness	1
4	Recruiting	Treatment	Coronary Artery Disease	1
4	Recruiting	Treatment	Myocardial Fibrosis	1
4	Recruiting	Treatment	PCOS, Insulin Resistance	1
4	Recruiting	Treatment	Portal Hypertension	1
4	Recruiting	Treatment	ST Elevation Myocardial Infarction (STEMI)	1
4	Terminated	Not Available	Statin Adverse Reaction / Statin-Associated Myopathy	1
4	Terminated	Treatment	Systemic Lupus Erythematosus (SLE)	1
4	Unknown Status	Prevention	Cholesterol, HDL	1
4	Unknown Status	Prevention	Diabetic Nephropathies	1
4	Unknown Status	Prevention	Hypertensive	1
4	Unknown Status	Prevention	Liver Cirrhosis / Portal Hypertension	2
4	Unknown Status	Treatment	Atherosclerosis / Dyslipidemias	1
4	Unknown Status	Treatment	Chronic Kidney Disease (CKD) / Hyperlipidemias	1
4	Unknown Status	Treatment	Chronic Nephropathy / Hypercholesterolaemia	1
4	Unknown Status	Treatment	Chronic Obstructive Pulmonary Disease (COPD) / Emphysema	1
4	Unknown Status	Treatment	Diabetes Mellitus (DM) / Hypertensive	1
4	Unknown Status	Treatment	High LDL Cholesterol Level / Systemic Lupus Erythematosus (SLE)	1
4	Unknown Status	Treatment	Hypertension,Essential	1
4	Unknown Status	Treatment	Hypertensive	2
4	Unknown Status	Treatment	Metabolic Syndromes	1
4	Unknown Status	Treatment	Perioperative Inflammatory Response	1
4	Unknown Status	Treatment	Peritoneal dialysis therapy / Renal Failure, End Stage	1
4	Unknown Status	Treatment	Shock, Septic	1
4	Unknown Status	Treatment	Type 2 Diabetes Mellitus Without Insulin Treatment	1
4	Unknown Status	Treatment	Mixed hypercholesterolemia	1
4	Withdrawn	Prevention	Schizoaffective Disorders / Schizophrenic Disorders	1
4	Withdrawn	Treatment	Cardiovascular Disease (CVD) / Hyperlipidemias	1
4	Withdrawn	Treatment	Cardiovascular Risk Factors / Community Acquired Pneumonia (CAP)	1
4	Withdrawn	Treatment	Dyslipidemias	1
4	Withdrawn	Treatment	Glucose Metabolism Disorders	1
Not Available	Completed	Not Available	Atherosclerosis / Cardiovascular Disease (CVD) / Coronary Heart Disease (CHD) / Heart Diseases / Myocardial Infarction (MI)	1
Not Available	Completed	Not Available	Atherosclerosis / Carotid Artery Diseases / Coronary Artery Disease	1
Not Available	Completed	Not Available	Cardiovascular Disease (CVD) / Type 2 Diabetes Mellitus	1
Not Available	Completed	Not Available	Hypercholesterolaemia	2
Not Available	Completed	Basic Science	Cardiovascular Disease (CVD) / Diabetes / Hypercholesterolaemia	1
Not Available	Completed	Basic Science	Heart Failure, Unspecified	1
Not Available	Completed	Basic Science	Hypercholesterolaemia	1
Not Available	Completed	Basic Science	Hyperglycemias	1
Not Available	Completed	Prevention	Alzheimer's Disease (AD)	1
Not Available	Completed	Prevention	Aneurysms / Congenital Heart Disease (CHD) / Heart Valve Disease / Rheumatic Heart Disease	1
Not Available	Completed	Prevention	Cardiovascular Disease (CVD)	1
Not Available	Completed	Prevention	Diabetic Nephropathies	1
Not Available	Completed	Prevention	Heart Diseases	1
Not Available	Completed	Prevention	Hyperlipidemias	1
Not Available	Completed	Treatment	Atherosclerosis	1
Not Available	Completed	Treatment	Bone Metastases of a Malignant Tumor	1
Not Available	Completed	Treatment	Cardiovascular Disease (CVD) / Cerebrovascular Diseases / Peripheral Arterial Disease (PAD)	1
Not Available	Completed	Treatment	Cardiovascular Risks / Hypercholesterolaemia / Inflammatory Reaction / Pre-Diabetic	1
Not Available	Completed	Treatment	Carotid Artery Diseases	1
Not Available	Completed	Treatment	Cholesterol, LDL	1
Not Available	Completed	Treatment	Chronic Renal Failure (CRF) / Hyperlipidemias / Hypertensive	1
Not Available	Completed	Treatment	Dyslipidemias	1
Not Available	Completed	Treatment	Healthy Volunteers	2
Not Available	Completed	Treatment	Inflammatory Reaction / Type 2 Diabetes Mellitus	1
Not Available	Completed	Treatment	Metabolic Syndromes / Obese / Sedentary	1
Not Available	Completed	Treatment	Peripheral Artery Disease (PAD)	1
Not Available	Completed	Treatment	Polycystic Ovaries Syndrome	1
Not Available	Completed	Treatment	Stable Angina (SA)	1
Not Available	Completed	Treatment	Mixed hypercholesterolemia / Type 2 Diabetes Mellitus	1
Not Available	Not Yet Recruiting	Not Available	Atherosclerosis / Cardiovascular Disease (CVD)	1
Not Available	Not Yet Recruiting	Treatment	Hyperlipidemias	1
Not Available	Recruiting	Diagnostic	Gluten Enteropathy	1
Not Available	Recruiting	Prevention	Congenital Heart Disease (CHD) / Heart Valve Disease	1
Not Available	Recruiting	Treatment	Atherosclerosis	1
Not Available	Recruiting	Treatment	Cirrhosis With Esophageal Varices / Cirrhosis With Large Esophageal Varices	1
Not Available	Recruiting	Treatment	Statin Intolerance	1
Not Available	Suspended	Prevention	Traumatic Brain Injury (TBI)	1
Not Available	Terminated	Not Available	Carotid Artery Diseases	1
Not Available	Terminated	Prevention	Aneurysmal Subarachnoid Hemorrhage / Cerebral Vasospasm	1
Not Available	Terminated	Prevention	Thoracic Pain	1
Not Available	Terminated	Treatment	Coronary Artery Disease	1
Not Available	Terminated	Treatment	Multiple Myeloma (MM)	1
Not Available	Terminated	Treatment	Schizophrenic Disorders	1
Not Available	Unknown Status	Not Available	Anti Inflammatory Non-Steroidal / Cystic Fibrosis (CF) / Neutrophils	1
Not Available	Unknown Status	Not Available	Endothelial Function	1
Not Available	Unknown Status	Not Available	Hypercholesterolaemia	1
Not Available	Unknown Status	Basic Science	Acute Coronary Syndromes (ACS)	1
Not Available	Unknown Status	Prevention	Pre-Diabetic / Pre-Hypertension	1
Not Available	Unknown Status	Screening	Cancers / Prostate	1
Not Available	Unknown Status	Treatment	Pachyonychia Congenita	1
Not Available	Unknown Status	Treatment	Polycystic Ovaries Syndrome	1
Not Available	Unknown Status	Treatment	Smith-Lemli-Opitz Syndrome	1
Not Available	Withdrawn	Basic Science	Hydroxymethylglutaryl-CoA Reductase Inhibitors / Myopathies	1
Not Available	Withdrawn	Prevention	Acute Lung Injury (ALI) / Acute Respiratory Distress Syndrome (ARDS)	1
Not Available	Withdrawn	Treatment	Atherosclerosis	1

Pharmacoeconomics

Manufacturers

Synthon pharmaceuticals ltd
Accord healthcare inc
Aurobindo pharma ltd
Dr reddys laboratories inc
Dr reddys laboratories ltd
Ivax pharmaceuticals inc sub teva pharmaceuticals usa
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Matrix laboratories ltd
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Ranbaxy laboratories ltd
Sandoz inc
Watson laboratories inc
Zydus pharmaceuticals usa inc
Merck research laboratories div merck co inc

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Abbott Laboratories Ltd.
Accord Healthcare
Advanced Pharmaceutical Services Inc.
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A-S Medication Solutions LLC
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Corepharma LLC
Coupler Enterprises Inc.
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DispenseXpress Inc.
Dispensing Solutions
Diversified Healthcare Services Inc.
Doctor Reddys Laboratories Ltd.
Intas Pharmaceuticals Ltd.
Kaiser Foundation Hospital
Laboratorios Belmac SA
Lake Erie Medical and Surgical Supply
Lupin Pharmaceuticals Inc.
Major Pharmaceuticals
Mallinckrodt Inc.
Mckesson Corp.
Medisca Inc.
Medvantx Inc.
Merck & Co.
MSP Distribution Services LLC
Murfreesboro Pharmaceutical Nursing Supply
Mylan
Northstar Rx LLC
Nucare Pharmaceuticals Inc.
Ohm Laboratories Inc.
Palmetto Pharmaceuticals Inc.
PCA LLC
PD-Rx Pharmaceuticals Inc.
Perrigo Co.
Pharmaceutical Utilization Management Program VA Inc.
Physicians Total Care Inc.
Preferred Pharmaceuticals Inc.
Prepackage Specialists
Prepak Systems Inc.
Ranbaxy Laboratories
Rebel Distributors Corp.
Remedy Repack
Resource Optimization and Innovation LLC
Sandhills Packaging Inc.
Sandoz
Southwood Pharmaceuticals
Stat Rx Usa
Stat Scripts LLC
Teva Pharmaceutical Industries Ltd.
UDL Laboratories
Va Cmop Dallas
Vangard Labs Inc.
Zydus Pharmaceuticals

Dosage forms

Form	Route	Strength
Tablet, film coated	Oral
Tablet	Oral	5 mg
Tablet	Oral	80 mg
Tablet, film coated, extended release	Oral
Tablet	Oral	10 mg/1
Tablet	Oral	20 mg/1
Tablet	Oral	40 mg/1
Tablet	Oral	5 mg/1
Tablet	Oral	80 mg/1
Tablet	Oral
Tablet	Oral	10 mg
Tablet	Oral	20 mg
Tablet	Oral	40 mg
Tablet, film coated	Oral	10 mg/1
Tablet, film coated	Oral	20 mg/1
Tablet, film coated	Oral	40 mg/1
Tablet, film coated	Oral	5 mg/1
Tablet, film coated	Oral	80 mg/1

Prices

Unit description	Cost	Unit
Zocor 90 40 mg tablet Bottle	525.16USD	bottle
Simvastatin 100% powder	10.71USD	g
Vytorin 10-20 mg tablet	5.05USD	tablet
Vytorin 10-40 mg tablet	5.05USD	tablet
Vytorin 10-10 mg tablet	4.97USD	tablet
Zocor 20 mg tablet	4.69USD	tablet
Zocor 80 mg tablet	4.69USD	tablet
Vytorin 10-80 mg tablet	4.63USD	tablet
Zocor 40 mg tablet	4.11USD	tablet
Simvastatin 20 mg tablet	3.83USD	tablet
Simvastatin 40 mg tablet	3.83USD	tablet
Simvastatin 80 mg tablet	3.83USD	tablet
Zocor 10 mg tablet	2.89USD	tablet
Simvastatin 10 mg tablet	2.31USD	tablet
Zocor 5 mg tablet	1.99USD	tablet
Simvastatin 5 mg tablet	1.63USD	tablet
Phl-Simvastatin 40 mg Tablet	1.45USD	tablet
Phl-Simvastatin 80 mg Tablet	1.45USD	tablet
Pms-Simvastatin 20 mg Tablet	1.45USD	tablet
Pms-Simvastatin 40 mg Tablet	1.45USD	tablet
Pms-Simvastatin 80 mg Tablet	1.45USD	tablet
Ran-Simvastatin 20 mg Tablet	1.45USD	tablet
Ran-Simvastatin 40 mg Tablet	1.45USD	tablet
Ran-Simvastatin 80 mg Tablet	1.45USD	tablet
Ratio-Simvastatin 20 mg Tablet	1.45USD	tablet
Ratio-Simvastatin 40 mg Tablet	1.45USD	tablet
Ratio-Simvastatin 80 mg Tablet	1.45USD	tablet
Sandoz Simvastatin 20 mg Tablet	1.45USD	tablet
Sandoz Simvastatin 40 mg Tablet	1.45USD	tablet
Sandoz Simvastatin 80 mg Tablet	1.45USD	tablet
Apo-Simvastatin 20 mg Tablet	1.45USD	tablet
Apo-Simvastatin 40 mg Tablet	1.45USD	tablet
Apo-Simvastatin 80 mg Tablet	1.45USD	tablet
Co Simvastatin 20 mg Tablet	1.45USD	tablet
Co Simvastatin 40 mg Tablet	1.45USD	tablet
Co Simvastatin 80 mg Tablet	1.45USD	tablet
Jamp-Simvastatin 20 mg Tablet	1.45USD	tablet
Jamp-Simvastatin 40 mg Tablet	1.45USD	tablet
Jamp-Simvastatin 80 mg Tablet	1.45USD	tablet
Mylan-Simvastatin 20 mg Tablet	1.45USD	tablet
Mylan-Simvastatin 40 mg Tablet	1.45USD	tablet
Mylan-Simvastatin 80 mg Tablet	1.45USD	tablet
Novo-Simvastatin 20 mg Tablet	1.45USD	tablet
Novo-Simvastatin 40 mg Tablet	1.45USD	tablet
Novo-Simvastatin 80 mg Tablet	1.45USD	tablet
Phl-Simvastatin 20 mg Tablet	1.45USD	tablet
Apo-Simvastatin 10 mg Tablet	1.17USD	tablet
Co Simvastatin 10 mg Tablet	1.17USD	tablet
Jamp-Simvastatin 10 mg Tablet	1.17USD	tablet
Mylan-Simvastatin 10 mg Tablet	1.17USD	tablet
Novo-Simvastatin 10 mg Tablet	1.17USD	tablet
Phl-Simvastatin 10 mg Tablet	1.17USD	tablet
Pms-Simvastatin 10 mg Tablet	1.17USD	tablet
Ran-Simvastatin 10 mg Tablet	1.17USD	tablet
Ratio-Simvastatin 10 mg Tablet	1.17USD	tablet
Sandoz Simvastatin 10 mg Tablet	1.17USD	tablet
Apo-Simvastatin 5 mg Tablet	0.59USD	tablet
Co Simvastatin 5 mg Tablet	0.59USD	tablet
Jamp-Simvastatin 5 mg Tablet	0.59USD	tablet
Mylan-Simvastatin 5 mg Tablet	0.59USD	tablet
Novo-Simvastatin 5 mg Tablet	0.59USD	tablet
Phl-Simvastatin 5 mg Tablet	0.59USD	tablet
Pms-Simvastatin 5 mg Tablet	0.59USD	tablet
Ran-Simvastatin 5 mg Tablet	0.59USD	tablet

DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.

Patents

Patent Number	Pediatric Extension	Approved	Expires (estimated)
US5846966	No	1993-09-21	2013-09-21	US
US6080428	No	1997-05-27	2017-05-27	US
US6303661	No	1997-04-24	2017-04-24	US
US6469035	No	1998-03-15	2018-03-15	US
US6699871	No	2002-07-26	2022-07-26	US
US6890898	No	1999-02-02	2019-02-02	US
US7078381	No	1999-02-02	2019-02-02	US
US7125873	No	2002-07-26	2022-07-26	US
US7326708	No	2006-04-11	2026-04-11	US
US7459428	No	1999-02-02	2019-02-02	US
US8168637	No	2002-06-26	2022-06-26	US
USRE37721	Yes	1997-04-25	2017-04-25	US
USRE42461	Yes	1997-04-25	2017-04-25	US

Properties

State

Solid

Experimental Properties

Property	Value	Source
melting point (°C)	135-138 °C	PhysProp
water solubility	Insoluble	FDA label
logP	4.68	HANSCH,C ET AL. (1995)

Predicted Properties

Property	Value	Source
Water Solubility	0.0122 mg/mL	ALOGPS
logP	4.51	ALOGPS
logP	4.46	ChemAxon
logS	-4.5	ALOGPS
pKa (Strongest Acidic)	14.91	ChemAxon
pKa (Strongest Basic)	-2.8	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	72.83 Å²	ChemAxon
Rotatable Bond Count	7	ChemAxon
Refractivity	117.68 m³·mol^-1	ChemAxon
Polarizability	47.85 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	1	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	Yes	ChemAxon

Predicted ADMET features

Property	Value	Probability
Human Intestinal Absorption	+	0.9475
Blood Brain Barrier	+	0.9422
Caco-2 permeable	-	0.5951
P-glycoprotein substrate	Substrate	0.8508
P-glycoprotein inhibitor I	Inhibitor	0.7335
P-glycoprotein inhibitor II	Inhibitor	0.8387
Renal organic cation transporter	Non-inhibitor	0.8435
CYP450 2C9 substrate	Non-substrate	0.835
CYP450 2D6 substrate	Non-substrate	0.9254
CYP450 3A4 substrate	Substrate	0.7513
CYP450 1A2 substrate	Non-inhibitor	0.9045
CYP450 2C9 inhibitor	Non-inhibitor	0.9071
CYP450 2D6 inhibitor	Non-inhibitor	0.9307
CYP450 2C19 inhibitor	Non-inhibitor	0.9025
CYP450 3A4 inhibitor	Inhibitor	0.7959
CYP450 inhibitory promiscuity	Low CYP Inhibitory Promiscuity	0.8682
Ames test	Non AMES toxic	0.792
Carcinogenicity	Non-carcinogens	0.9408
Biodegradation	Not ready biodegradable	0.9657
Rat acute toxicity	2.0061 LD50, mol/kg	Not applicable
hERG inhibition (predictor I)	Weak inhibitor	0.8921
hERG inhibition (predictor II)	Non-inhibitor	0.8573

ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )

Spectra

Mass Spec (NIST)

Not Available

Spectra

Spectrum Type	Description	Splash Key
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF , positive	splash10-0fya-0988400000-d9778b2f11696b81fb07	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF , positive	splash10-006w-0790000000-4f23e0376d85845e0964	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF , positive	splash10-05i1-0940000000-058f6298af54c05532ed	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF , positive	splash10-0092-0910000000-6ecd838b2f6fddf67dad	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF , positive	splash10-0597-0900000000-012d0d6fcabbd21d696d	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QFT , positive	splash10-000e-0590000000-7f99e0b9531d4f42831a	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QFT , positive	splash10-0092-1960000000-e8429bbec985c5ecdd2d	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QFT , positive	splash10-0592-1910000000-dc09a51ca37fe4d24a5a	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QFT , positive	splash10-0abd-1900000000-9b55821f49270e5dd598	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QFT , positive	splash10-0536-1900000000-d8a41a97ccbdb30e5a5e	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QFT , positive	splash10-002f-2900000000-abe04d7f99c3eb0f2fcb	View in MoNA
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	Not Available
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	Not Available
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	Not Available
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	Not Available
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	Not Available
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	Not Available
MS	Mass Spectrum (Electron Ionization)	splash10-0a4i-3900000000-d04758924bf88a90c017	View in MoNA

Taxonomy

Description

This compound belongs to the class of chemical entities known as delta valerolactones. These are cyclic organic compounds containing an oxan-2- one moiety.

Kingdom

Chemical entities

Super Class

Organic compounds

Class

Organoheterocyclic compounds

Sub Class

Lactones

Direct Parent

Delta valerolactones

Alternative Parents

Fatty acid esters / Oxanes / Dicarboxylic acids and derivatives / Secondary alcohols / Carboxylic acid esters / Oxacyclic compounds / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds

Substituents

Delta valerolactone / Fatty acid ester / Delta_valerolactone / Dicarboxylic acid or derivatives / Oxane / Fatty acyl / Carboxylic acid ester / Secondary alcohol / Carboxylic acid derivative / Oxacycle

Molecular Framework

Aliphatic heteropolycyclic compounds

External Descriptors

statin (semi-synthetic), fatty acid ester, delta-lactone, carbobicyclic compound (CHEBI:9150 )

Targets

Details

1. 3-hydroxy-3-methylglutaryl-coenzyme A reductase

Kind: Protein
Organism: Human
Pharmacological action: yes
Actions: inhibitor

General Function:: Nadph binding
Specific Function:: Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.
Gene Name:: HMGCR
Uniprot ID:: P04035
Molecular Weight:: 97475.155 Da

References

Cenedella RJ, Kuszak JR, Al-Ghoul KJ, Qin S, Sexton PS: Discordant expression of the sterol pathway in lens underlies simvastatin-induced cataracts in Chbb: Thom rats. J Lipid Res. 2003 Jan;44(1):198-211. [PubMed:12518039 ]
Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
Kocarek TA, Dahn MS, Cai H, Strom SC, Mercer-Haines NA: Regulation of CYP2B6 and CYP3A expression by hydroxymethylglutaryl coenzyme A inhibitors in primary cultured human hepatocytes. Drug Metab Dispos. 2002 Dec;30(12):1400-5. [PubMed:12433810 ]
Liu L, Zhang R, Zhao JJ, Rogers JD, Hsieh JY, Fang W, Matuszewski BK, Dobrinska MR: Determination of simvastatin-derived HMG-CoA reductase inhibitors in biomatrices using an automated enzyme inhibition assay with radioactivity detection. J Pharm Biomed Anal. 2003 Apr 24;32(1):107-23. [PubMed:12852453 ]
Pappu AS, Bacon SP, Illingworth DR: Residual effects of lovastatin and simvastatin on urinary mevalonate excretions in patients with familial hypercholesterolemia. J Lab Clin Med. 2003 Apr;141(4):250-6. [PubMed:12677170 ]
Stoebner PE, Michot C, Ligeron C, Durand L, Meynadier J, Meunier L: [Simvastatin-induced lichen planus pemphigoides]. Ann Dermatol Venereol. 2003 Feb;130(2 Pt 1):187-90. [PubMed:12671581 ]

Details

2. Integrin beta-2

Kind: Protein
Organism: Human
Pharmacological action: no
Actions: other

General Function:: Protein kinase binding
Specific Function:: Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is a...
Gene Name:: ITGB2
Uniprot ID:: P05107
Molecular Weight:: 84781.08 Da

References

Fujii T, Masuyama K, Kawashima K: Simvastatin regulates non-neuronal cholinergic activity in T lymphocytes via CD11a-mediated pathways. J Neuroimmunol. 2006 Oct;179(1-2):101-7. Epub 2006 Jul 10. [PubMed:16828882 ]
Fujii T, Takada-Takatori Y, Kawashima K: Roles played by lymphocyte function-associated antigen-1 in the regulation of lymphocytic cholinergic activity. Life Sci. 2007 May 30;80(24-25):2320-4. Epub 2007 Jan 17. [PubMed:17289088 ]
Katano H, Pesnicak L, Cohen JI: Simvastatin induces apoptosis of Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines and delays development of EBV lymphomas. Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):4960-5. Epub 2004 Mar 23. [PubMed:15041742 ]
Takahashi HK, Mori S, Iwagaki H, Yoshino T, Tanaka N, Nishibori M: Simvastatin induces interleukin-18 production in human peripheral blood mononuclear cells. Clin Immunol. 2005 Sep;116(3):211-6. [PubMed:15936988 ]

Details

3. Integrin alpha-L

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: inhibitor

General Function:: Metal ion binding
Specific Function:: Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.
Gene Name:: ITGAL
Uniprot ID:: P20701
Molecular Weight:: 128768.495 Da

References

Katano H, Pesnicak L, Cohen JI: Simvastatin induces apoptosis of Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines and delays development of EBV lymphomas. Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):4960-5. Epub 2004 Mar 23. [PubMed:15041742 ]

Enzymes

Details

1. Cytochrome P450 3A4

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: substrateinhibitorinducer

General Function:: Vitamin d3 25-hydroxylase activity
Specific Function:: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:: CYP3A4
Uniprot ID:: P08684
Molecular Weight:: 57342.67 Da

References

Neuvonen PJ, Niemi M, Backman JT: Drug interactions with lipid-lowering drugs: mechanisms and clinical relevance. Clin Pharmacol Ther. 2006 Dec;80(6):565-81. [PubMed:17178259 ]
Cohen LH, van Leeuwen RE, van Thiel GC, van Pelt JF, Yap SH: Equally potent inhibitors of cholesterol synthesis in human hepatocytes have distinguishable effects on different cytochrome P450 enzymes. Biopharm Drug Dispos. 2000 Dec;21(9):353-64. [PubMed:11523064 ]
Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Galetin A, Clarke SE, Houston JB: Quinidine and haloperidol as modifiers of CYP3A4 activity: multisite kinetic model approach. Drug Metab Dispos. 2002 Dec;30(12):1512-22. [PubMed:12433827 ]
Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Website [Link]

Details

2. Cytochrome P450 3A5

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: substrate

General Function:: Oxygen binding
Specific Function:: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:: CYP3A5
Uniprot ID:: P20815
Molecular Weight:: 57108.065 Da

References

Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]

Details

3. Cytochrome P450 3A7

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: substrate

General Function:: Oxygen binding
Specific Function:: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:: CYP3A7
Uniprot ID:: P24462
Molecular Weight:: 57525.03 Da

References

Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]

Details

4. Cytochrome P450 2C8

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: substrateinhibitor

General Function:: Steroid hydroxylase activity
Specific Function:: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme...
Gene Name:: CYP2C8
Uniprot ID:: P10632
Molecular Weight:: 55824.275 Da

References

Neuvonen PJ, Niemi M, Backman JT: Drug interactions with lipid-lowering drugs: mechanisms and clinical relevance. Clin Pharmacol Ther. 2006 Dec;80(6):565-81. [PubMed:17178259 ]
Tornio A, Pasanen MK, Laitila J, Neuvonen PJ, Backman JT: Comparison of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) as inhibitors of cytochrome P450 2C8. Basic Clin Pharmacol Toxicol. 2005 Aug;97(2):104-8. [PubMed:15998357 ]
Walsky RL, Gaman EA, Obach RS: Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol. 2005 Jan;45(1):68-78. [PubMed:15601807 ]
Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Details

5. Cytochrome P450 2C9

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: inhibitorinducer

General Function:: Steroid hydroxylase activity
Specific Function:: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:: CYP2C9
Uniprot ID:: P11712
Molecular Weight:: 55627.365 Da

References

Cohen LH, van Leeuwen RE, van Thiel GC, van Pelt JF, Yap SH: Equally potent inhibitors of cholesterol synthesis in human hepatocytes have distinguishable effects on different cytochrome P450 enzymes. Biopharm Drug Dispos. 2000 Dec;21(9):353-64. [PubMed:11523064 ]
Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Details

6. Cytochrome P450 2C19

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: inhibitor

General Function:: Steroid hydroxylase activity
Specific Function:: Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:: CYP2C19
Uniprot ID:: P33261
Molecular Weight:: 55930.545 Da

References

Cohen LH, van Leeuwen RE, van Thiel GC, van Pelt JF, Yap SH: Equally potent inhibitors of cholesterol synthesis in human hepatocytes have distinguishable effects on different cytochrome P450 enzymes. Biopharm Drug Dispos. 2000 Dec;21(9):353-64. [PubMed:11523064 ]

Details

7. Cytochrome P450 2D6

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: substrateinhibitor

General Function:: Steroid hydroxylase activity
Specific Function:: Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:: CYP2D6
Uniprot ID:: P10635
Molecular Weight:: 55768.94 Da

References

Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Details

8. Cytochrome P450 2B6

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: inducer

General Function:: Steroid hydroxylase activity
Specific Function:: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Gene Name:: CYP2B6
Uniprot ID:: P20813
Molecular Weight:: 56277.81 Da

References

Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]

Details

9. UDP-glucuronosyltransferase 1-1

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: substrate

General Function:: Steroid binding
Specific Function:: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4-methylumbelliferone, 1-naph...
Gene Name:: UGT1A1
Uniprot ID:: P22309
Molecular Weight:: 59590.91 Da

Details

10. UDP-glucuronosyltransferase 1-3

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: substrate

General Function:: Retinoic acid binding
Specific Function:: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.
Gene Name:: UGT1A3
Uniprot ID:: P35503
Molecular Weight:: 60337.835 Da

Details

11. UDP-glucuronosyltransferase 2B7

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: substrate

General Function:: Glucuronosyltransferase activity
Specific Function:: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.Its unique specificity for 3,4-catechol estrogens and estriol suggests it may play an important role in regulating the level and activity of these potent and active estrogen metabolites. Is also active with androsterone, hyodeoxycholic acid and tetrachlorocatechol...
Gene Name:: UGT2B7
Uniprot ID:: P16662
Molecular Weight:: 60694.12 Da

Transporters

Details

1. Multidrug resistance protein 1

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: inhibitor

General Function:: Xenobiotic-transporting atpase activity
Specific Function:: Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:: ABCB1
Uniprot ID:: P08183
Molecular Weight:: 141477.255 Da

References

Wang E, Casciano CN, Clement RP, Johnson WW: HMG-CoA reductase inhibitors (statins) characterized as direct inhibitors of P-glycoprotein. Pharm Res. 2001 Jun;18(6):800-6. [PubMed:11474784 ]
Wang EJ, Casciano CN, Clement RP, Johnson WW: Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors. Biochem Biophys Res Commun. 2001 Nov 30;289(2):580-5. [PubMed:11716514 ]
Hochman JH, Pudvah N, Qiu J, Yamazaki M, Tang C, Lin JH, Prueksaritanont T: Interactions of human P-glycoprotein with simvastatin, simvastatin acid, and atorvastatin. Pharm Res. 2004 Sep;21(9):1686-91. [PubMed:15497697 ]
Sieczkowski E, Lehner C, Ambros PF, Hohenegger M: Double impact on p-glycoprotein by statins enhances doxorubicin cytotoxicity in human neuroblastoma cells. Int J Cancer. 2010 May 1;126(9):2025-35. doi: 10.1002/ijc.24885. [PubMed:19739078 ]

Details

2. Solute carrier organic anion transporter family member 1A2

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: inhibitor

General Function:: Sodium-independent organic anion transmembrane transporter activity
Specific Function:: Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin.
Gene Name:: SLCO1A2
Uniprot ID:: P46721
Molecular Weight:: 74144.105 Da

References

Hsiang B, Zhu Y, Wang Z, Wu Y, Sasseville V, Yang WP, Kirchgessner TG: A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters. J Biol Chem. 1999 Dec 24;274(52):37161-8. [PubMed:10601278 ]

Details

3. Solute carrier organic anion transporter family member 1B1

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: substrateinhibitor

General Function:: Sodium-independent organic anion transmembrane transporter activity
Specific Function:: Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver.
Gene Name:: SLCO1B1
Uniprot ID:: Q9Y6L6
Molecular Weight:: 76447.99 Da

References

Hsiang B, Zhu Y, Wang Z, Wu Y, Sasseville V, Yang WP, Kirchgessner TG: A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters. J Biol Chem. 1999 Dec 24;274(52):37161-8. [PubMed:10601278 ]
Kameyama Y, Yamashita K, Kobayashi K, Hosokawa M, Chiba K: Functional characterization of SLCO1B1 (OATP-C) variants, SLCO1B1*5, SLCO1B1*15 and SLCO1B1*15+C1007G, by using transient expression systems of HeLa and HEK293 cells. Pharmacogenet Genomics. 2005 Jul;15(7):513-22. [PubMed:15970799 ]

Details

4. Canalicular multispecific organic anion transporter 1

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: substrate

General Function:: Organic anion transmembrane transporter activity
Specific Function:: Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.
Gene Name:: ABCC2
Uniprot ID:: Q92887
Molecular Weight:: 174205.64 Da

References

Becker ML, Elens LL, Visser LE, Hofman A, Uitterlinden AG, van Schaik RH, Stricker BH: Genetic variation in the ABCC2 gene is associated with dose decreases or switches to other cholesterol-lowering drugs during simvastatin and atorvastatin therapy. Pharmacogenomics J. 2013 Jun;13(3):251-6. doi: 10.1038/tpj.2011.59. Epub 2011 Dec 20. [PubMed:22186618 ]

Drug created on June 13, 2005 07:24 / Updated on July 11, 2017 01:58

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Structure for DB00641 (Simvastatin)

Targets

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Enzymes

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Transporters

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