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Identification
NameLovastatin
Accession NumberDB00227  (APRD00370)
TypeSmall Molecule
GroupsApproved, Investigational
DescriptionLovastatin is a cholesterol-lowering agent that belongs to the class of medications called statins. It was the second agent of this class discovered. It was discovered by Alfred Alberts and his team at Merck in 1978 after screening only 18 compounds over 2 weeks. The agent, also known as mevinolin, was isolated from the fungi Aspergillus terreus. Research on this compound was suddenly shut down in 1980 and the drug was not approved until 1987. Interesting, Akira Endo at Sankyo Co. (Japan) patented lovastatin isolated from Monascus ruber four months before Merck. Lovastatin was found to be 2 times more potent than its predecessor, mevastatin, the first discovered statin. Like mevastatin, lovastatin is structurally similar to hydroxymethylglutarate (HMG), a substituent of HMG-Coenzyme A (HMG-CoA), a substrate of the cholesterol biosynthesis pathway via the mevalonic acid pathway. Lovastatin is a competitive inhibitor of HMG-CoA reductase with a binding affinity 20,000 times greater than HMG-CoA. Lovastatin differs structurally from mevastatin by a single methyl group at the 6’ position. Lovastatin is a prodrug that is activated by in vivo hydrolysis of the lactone ring. It, along with mevastatin, has served as one of the lead compounds for the development of the synthetic compounds used today.
Structure
Thumb
Synonyms
(1S,3R,7S,8S,8AR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(2R,4R)-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl (S)-2-methyl-butyrate
2beta,6alpha-Dimethyl-8alpha-(2-methyl-1-oxobutoxy)-mevinic acid lactone
6-alpha-methylcompactin
6alpha-Methylcompactin
6α-methylcompactin
LOVASTATIN
Lovastatina
Lovastatine
Lovastatinum
Mevacor
Mevinolin
MK-803
ML-530b
External Identifiers
  • MK-803
  • ML-530B
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Act LovastatinTablet20 mgOralActavis Pharma Company2004-07-28Not applicableCanada
Act LovastatinTablet40 mgOralActavis Pharma Company2004-07-28Not applicableCanada
AltoprevTablet, extended release40 mg/1OralShionogi Inc.2002-06-262018-02-28Us
AltoprevTablet, extended release20 mg/1OralCovis Pharma2016-05-01Not applicableUs
AltoprevTablet, extended release60 mg/1OralShionogi Inc.2002-06-262016-12-31Us
AltoprevTablet, extended release40 mg/1OralCovis Pharma2016-05-01Not applicableUs
AltoprevTablet, extended release60 mg/1OralCovis Pharma2016-05-01Not applicableUs
AltoprevTablet, extended release20 mg/1OralShionogi Inc.2002-06-262017-12-31Us
Ava-lovastatinTablet20 mgOralAvanstra Inc2011-08-182014-08-21Canada
Ava-lovastatinTablet40 mgOralAvanstra Inc2011-08-182014-08-21Canada
Dom-lovastatinTablet20 mgOralDominion Pharmacal2003-02-25Not applicableCanada
Dom-lovastatinTablet40 mgOralDominion Pharmacal2003-02-25Not applicableCanada
LovastatinTablet40 mgOralSanis Health Inc2010-07-26Not applicableCanada
LovastatinTablet40 mgOralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
LovastatinTablet20 mgOralSanis Health Inc2010-07-26Not applicableCanada
LovastatinTablet20 mgOralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Lovastatin-20Tablet20 mgOralPro Doc Limitee2003-08-152008-07-09Canada
Lovastatin-40Tablet40 mgOralPro Doc Limitee2003-08-152008-07-09Canada
MevacorTablet20 mg/1OralMerck Sharp & Dohme Corp.1987-08-31Not applicableUs
MevacorTablet40 mg/1OralMerck Sharp & Dohme Corp.1987-08-31Not applicableUs
MevacorTablet20 mgOralMerck Canada Inc1988-12-312014-06-06Canada
MevacorTablet40 mgOralMerck Canada Inc1990-12-312014-06-06Canada
Mylan-lovastatinTablet20 mgOralMylan Pharmaceuticals Ulc2001-02-08Not applicableCanada
Mylan-lovastatinTablet40 mgOralMylan Pharmaceuticals Ulc2001-02-19Not applicableCanada
Nu-lovastatin TabletsTablet20 mgOralNu Pharm Inc2004-12-172012-09-04Canada
PHL-lovastatinTablet20 mgOralPharmel Inc2003-01-07Not applicableCanada
PHL-lovastatinTablet40 mgOralPharmel Inc2003-01-07Not applicableCanada
PMS-lovastatinTablet20 mgOralPharmascience Inc2002-07-12Not applicableCanada
PMS-lovastatinTablet40 mgOralPharmascience Inc2002-07-16Not applicableCanada
Pro-lovastatinTablet20 mgOralPro Doc Limitee2008-07-09Not applicableCanada
Pro-lovastatinTablet40 mgOralPro Doc Limitee2008-07-09Not applicableCanada
Ran-lovastatinTablet20 mgOralRanbaxy Pharmaceuticals Canada Inc.2005-07-052012-06-13Canada
Ran-lovastatinTablet40 mgOralRanbaxy Pharmaceuticals Canada Inc.2005-07-052012-06-13Canada
Ratio-lovastatinTablet20 mgOralRatiopharm Inc Division Of Teva Canada Limited2002-05-222013-01-09Canada
Ratio-lovastatinTablet40 mgOralRatiopharm Inc Division Of Teva Canada Limited2002-05-222013-01-09Canada
Riva-lovastatinTablet40 mgOralLaboratoire Riva Inc2005-12-07Not applicableCanada
Riva-lovastatinTablet20 mgOralLaboratoire Riva Inc2005-12-01Not applicableCanada
Sandoz LovastatinTablet40 mgOralSandoz Canada Incorporated2003-02-27Not applicableCanada
Sandoz LovastatinTablet20 mgOralSandoz Canada Incorporated2003-02-27Not applicableCanada
Teva-lovastatinTablet20 mgOralTeva Canada Limited2003-01-20Not applicableCanada
Teva-lovastatinTablet40 mgOralTeva Canada Limited2003-01-20Not applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-lovastatin - Tab 20mgTablet20 mgOralApotex Inc1997-03-27Not applicableCanada
Apo-lovastatin - Tab 40mgTablet40 mgOralApotex Inc1997-03-27Not applicableCanada
LovastatinTablet20 mg/1OralMylan Pharmaceuticals Inc.2001-12-17Not applicableUs
LovastatinTablet20 mg/1OralRebel Distributors Corp2007-11-01Not applicableUs
LovastatinTablet10 mg/1OralREMEDYREPACK INC.2010-10-172016-10-22Us
LovastatinTablet40 mg/1OralAv Pak2014-04-29Not applicableUs
LovastatinTablet40 mg/1OralPhysicians Total Care, Inc.2003-04-14Not applicableUs
LovastatinTablet20 mg/1OralCarlsbad Technology, Inc.2002-11-25Not applicableUs
LovastatinTablet10 mg/1OralAmerican Health Packaging2012-01-31Not applicableUs
LovastatinTablet20 mg/1OralBlue Point Laboratories2014-02-10Not applicableUs
LovastatinTablet20 mg/1OralA S Medication Solutions2001-12-17Not applicableUs
LovastatinTablet10 mg/1OralKAISER FOUNDATION HOSPITALS2011-07-18Not applicableUs
LovastatinTablet40 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2001-12-17Not applicableUs
LovastatinTablet20 mg/1OralRebel Distributors Corp2002-11-25Not applicableUs
LovastatinTablet10 mg/1OralREMEDYREPACK INC.2013-02-13Not applicableUs
LovastatinTablet20 mg/1OralMutual Pharmaceutical Company, Inc.2006-04-14Not applicableUs
LovastatinTablet10 mg/1OralGolden State Medical Supply, Inc.2014-06-24Not applicableUs
LovastatinTablet10 mg/1Oralbryant ranch prepack2002-11-25Not applicableUs
LovastatinTablet10 mg/1OralREMEDYREPACK INC.2013-09-26Not applicableUs
LovastatinTablet20 mg/1OralPreferred Pharmaceuticals, Inc.2013-03-18Not applicableUs
LovastatinTablet10 mg/1OralUnit Dose Services2002-11-25Not applicableUs
LovastatinTablet20 mg/1OralPd Rx Pharmaceuticals, Inc.2007-11-01Not applicableUs
LovastatinTablet10 mg/1OralProficient Rx LP2002-11-25Not applicableUs
LovastatinTablet20 mg/1OralLupin Pharmaceuticals, Inc.2007-11-01Not applicableUs
LovastatinTablet20 mg/1OralA S Medication Solutions2001-12-17Not applicableUs
LovastatinTablet40 mg/1OralTeva Pharmaceuticals Usa, Inc.2001-12-17Not applicableUs
LovastatinTablet10 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2001-12-17Not applicableUs
LovastatinTablet20 mg/1OralAidarex Pharmaceuticals LLC2002-11-25Not applicableUs
LovastatinTablet10 mg/1OralREMEDYREPACK INC.2011-03-16Not applicableUs
LovastatinTablet20 mg/1OralMylan Institutional Inc.2002-01-15Not applicableUs
LovastatinTablet10 mg/1OralInternational Labs, Inc.2008-03-27Not applicableUs
LovastatinTablet10 mg/1OralSt Marys Medical Park Pharmacy2014-01-30Not applicableUs
LovastatinTablet20 mg/1OralAphena Pharma Solutions Tennessee, Llc2001-12-17Not applicableUs
LovastatinTablet10 mg/1OralInternational Laboratories, Inc.2010-03-22Not applicableUs
LovastatinTablet20 mg/1OralPreferred Pharmaceuticals, Inc.2013-07-29Not applicableUs
LovastatinTablet20 mg/1OralInternational Laboratories, Inc.2015-05-20Not applicableUs
LovastatinTablet20 mg/1OralEon Labs, Inc.2001-12-17Not applicableUs
LovastatinTablet20 mg/1OralBlenheim Pharmacal, Inc.2010-06-22Not applicableUs
LovastatinTablet10 mg/1OralPd Rx Pharmaceuticals, Inc.2007-11-01Not applicableUs
LovastatinTablet40 mg/1OralLake Erie Medical DBA Quality Care Products LLC2007-11-01Not applicableUs
LovastatinTablet40 mg/1OralMylan Pharmaceuticals Inc.2001-12-17Not applicableUs
LovastatinTablet40 mg/1OralRebel Distributors Corp2007-11-01Not applicableUs
LovastatinTablet40 mg/1OralREMEDYREPACK INC.2011-06-172016-10-21Us
LovastatinTablet10 mg/1OralUnit Dose Services2002-11-25Not applicableUs
LovastatinTablet20 mg/1OralCardinal Health2011-08-18Not applicableUs
LovastatinTablet40 mg/1OralCarlsbad Technology, Inc.2002-11-25Not applicableUs
LovastatinTablet20 mg/1OralAmerican Health Packaging2012-01-31Not applicableUs
LovastatinTablet20 mg/1OralPd Rx Pharmaceuticals, Inc.2002-11-25Not applicableUs
LovastatinTablet20 mg/1OralDIRECT RX2016-03-03Not applicableUs
LovastatinTablet40 mg/1OralREMEDYREPACK INC.2016-10-31Not applicableUs
LovastatinTablet10 mg/1OralUnit Dose Services2007-11-01Not applicableUs
LovastatinTablet20 mg/1OralKAISER FOUNDATION HOSPITALS2011-07-18Not applicableUs
LovastatinTablet10 mg/1OralBlenheim Pharmacal, Inc.2013-10-09Not applicableUs
LovastatinTablet10 mg/1OralRebel Distributors Corp2002-11-25Not applicableUs
LovastatinTablet20 mg/1OralREMEDYREPACK INC.2013-02-15Not applicableUs
LovastatinTablet40 mg/1OralMutual Pharmaceutical Company, Inc.2006-04-14Not applicableUs
LovastatinTablet20 mg/1OralGolden State Medical Supply, Inc.2014-06-24Not applicableUs
LovastatinTablet20 mg/1OralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2007-09-12Not applicableUs
LovastatinTablet40 mg/1OralREMEDYREPACK INC.2014-02-20Not applicableUs
LovastatinTablet10 mg/1OralPreferred Pharmaceuticals, Inc2005-10-27Not applicableUs
LovastatinTablet10 mg/1OralNorthwind Pharmaceuticals, LLC2014-11-04Not applicableUs
LovastatinTablet10 mg/1OralGolden State Medical Supply, Inc.2002-11-25Not applicableUs
LovastatinTablet40 mg/1OralProficient Rx LP2002-11-25Not applicableUs
LovastatinTablet40 mg/1OralLupin Pharmaceuticals, Inc.2007-11-01Not applicableUs
LovastatinTablet20 mg/1OralA S Medication Solutions2007-11-01Not applicableUs
LovastatinTablet10 mg/1OralActavis Pharma, Inc.2001-12-17Not applicableUs
LovastatinTablet10 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2011-11-01Not applicableUs
LovastatinTablet40 mg/1OralAidarex Pharmaceuticals LLC2002-11-25Not applicableUs
LovastatinTablet10 mg/1OralREMEDYREPACK INC.2011-10-202016-11-05Us
LovastatinTablet40 mg/1OralPd Rx Pharmaceuticals, Inc.2002-11-25Not applicableUs
LovastatinTablet10 mg/1OralAv Pak2014-04-29Not applicableUs
LovastatinTablet20 mg/1OralPhysicians Total Care, Inc.2001-12-21Not applicableUs
LovastatinTablet40 mg/1OralSt Marys Medical Park Pharmacy2014-04-21Not applicableUs
LovastatinTablet40 mg/1OralAphena Pharma Solutions Tennessee, Llc2001-12-17Not applicableUs
LovastatinTablet10 mg/1OralBlue Point Laboratories2014-02-10Not applicableUs
LovastatinTablet40 mg/1OralPreferred Pharmaceuticals, Inc.2013-07-29Not applicableUs
LovastatinTablet40 mg/1OralDIRECT RX2014-01-01Not applicableUs
LovastatinTablet40 mg/1OralEon Labs, Inc.2001-12-17Not applicableUs
LovastatinTablet10 mg/1OralSTAT Rx USA LLC2007-11-01Not applicableUs
LovastatinTablet40 mg/1OralAphena Pharma Solutions Tennessee, Llc2014-06-24Not applicableUs
LovastatinTablet20 mg/1OralTeva Pharmaceuticals Usa, Inc.2001-12-17Not applicableUs
LovastatinTablet40 mg/1OralREMEDYREPACK INC.2011-03-092017-11-22Us
LovastatinTablet20 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2001-12-17Not applicableUs
LovastatinTablet20 mg/1OralREMEDYREPACK INC.2011-12-122016-10-25Us
LovastatinTablet40 mg/1OralREMEDYREPACK INC.2011-09-232016-10-13Us
LovastatinTablet40 mg/1OralUnit Dose Services2002-11-25Not applicableUs
LovastatinTablet20 mg/1OralCardinal Health2010-12-14Not applicableUs
LovastatinTablet10 mg/1OralDIRECT RX2014-01-01Not applicableUs
LovastatinTablet40 mg/1OralAmerican Health Packaging2012-01-31Not applicableUs
LovastatinTablet40 mg/1OralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2007-08-06Not applicableUs
LovastatinTablet40 mg/1OralInternational Laboratories, Inc.2010-04-10Not applicableUs
LovastatinTablet20 mg/1OralPreferred Pharmaceuticals, Inc2005-10-27Not applicableUs
LovastatinTablet20 mg/1OralUnit Dose Services2007-11-01Not applicableUs
LovastatinTablet40 mg/1OralKAISER FOUNDATION HOSPITALS2011-07-18Not applicableUs
LovastatinTablet20 mg/1OralBlenheim Pharmacal, Inc.2013-10-09Not applicableUs
LovastatinTablet20 mg/1OralAv Kare, Inc.2002-06-06Not applicableUs
LovastatinTablet40 mg/1OralREMEDYREPACK INC.2012-09-112016-10-26Us
LovastatinTablet40 mg/1OralInternational Labs, Inc.2008-03-27Not applicableUs
LovastatinTablet40 mg/1OralGolden State Medical Supply, Inc.2014-06-24Not applicableUs
LovastatinTablet20 mg/1OralLake Erie Medical DBA Quality Care Products LLC2001-12-17Not applicableUs
LovastatinTablet40 mg/1OralREMEDYREPACK INC.2011-12-02Not applicableUs
LovastatinTablet20 mg/1OralREMEDYREPACK INC.2013-05-14Not applicableUs
LovastatinTablet20 mg/1OralGolden State Medical Supply, Inc.2002-11-25Not applicableUs
LovastatinTablet20 mg/1Oralbryant ranch prepack2009-06-15Not applicableUs
LovastatinTablet40 mg/1OralPreferred Pharmaceuticals, Inc.2013-03-18Not applicableUs
LovastatinTablet40 mg/1OralA S Medication Solutions2007-11-01Not applicableUs
LovastatinTablet20 mg/1OralActavis Pharma, Inc.2001-12-17Not applicableUs
LovastatinTablet20 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2001-12-17Not applicableUs
LovastatinTablet10 mg/1OralRebel Distributors Corp2007-11-01Not applicableUs
LovastatinTablet40 mg/1OralAphena Pharma Solutions Tennessee, Llc2002-06-06Not applicableUs
LovastatinTablet20 mg/1OralAv Pak2014-04-29Not applicableUs
LovastatinTablet10 mg/1OralPhysicians Total Care, Inc.2002-01-28Not applicableUs
LovastatinTablet10 mg/1OralCarlsbad Technology, Inc.2002-11-25Not applicableUs
LovastatinTablet10 mg/1OralAphena Pharma Solutions Tennessee, Llc2001-12-17Not applicableUs
LovastatinTablet40 mg/1OralBlue Point Laboratories2014-02-10Not applicableUs
LovastatinTablet20 mg/1OralDIRECT RX2014-01-01Not applicableUs
LovastatinTablet10 mg/1OralMylan Pharmaceuticals Inc.2001-12-17Not applicableUs
LovastatinTablet20 mg/1OralProficient Rx LP2002-11-25Not applicableUs
LovastatinTablet10 mg/1OralLupin Pharmaceuticals, Inc.2007-11-01Not applicableUs
LovastatinTablet10 mg/1OralA S Medication Solutions2002-11-25Not applicableUs
LovastatinTablet10 mg/1OralTeva Pharmaceuticals Usa, Inc.2001-12-17Not applicableUs
LovastatinTablet40 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2001-12-17Not applicableUs
LovastatinTablet10 mg/1OralAidarex Pharmaceuticals LLC2002-11-25Not applicableUs
LovastatinTablet10 mg/1OralREMEDYREPACK INC.2011-10-242016-12-02Us
LovastatinTablet20 mg/1OralUnit Dose Services2002-11-25Not applicableUs
LovastatinTablet40 mg/1OralPd Rx Pharmaceuticals, Inc.2007-11-01Not applicableUs
LovastatinTablet20 mg/1OralInternational Labs, Inc.2008-03-27Not applicableUs
LovastatinTablet20 mg/1OralSt Marys Medical Park Pharmacy2013-07-11Not applicableUs
LovastatinTablet10 mg/1OralDispensing Solutions, Inc.2002-11-25Not applicableUs
LovastatinTablet20 mg/1OralInternational Laboratories, Inc.2010-04-03Not applicableUs
LovastatinTablet40 mg/1OralPreferred Pharmaceuticals, Inc2005-10-27Not applicableUs
LovastatinTablet40 mg/1OralInternational Laboratories, Inc.2015-05-20Not applicableUs
LovastatinTablet10 mg/1OralEon Labs, Inc.2001-12-17Not applicableUs
LovastatinTablet40 mg/1OralBlenheim Pharmacal, Inc.2013-10-09Not applicableUs
LovastatinTablet40 mg/1OralAv Kare, Inc.2002-06-06Not applicableUs
LovastatinTablet10 mg/1OralLake Erie Medical DBA Quality Care Products LLC2001-12-17Not applicableUs
LovastatinTablet40 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2001-12-17Not applicableUs
LovastatinTablet40 mg/1OralRebel Distributors Corp2002-11-25Not applicableUs
LovastatinTablet20 mg/1OralREMEDYREPACK INC.2013-04-09Not applicableUs
LovastatinTablet10 mg/1OralMutual Pharmaceutical Company, Inc.2006-04-14Not applicableUs
LovastatinTablet40 mg/1OralGolden State Medical Supply, Inc.2002-11-25Not applicableUs
LovastatinTablet40 mg/1Oralbryant ranch prepack2001-12-17Not applicableUs
LovastatinTablet10 mg/1OralPreferred Pharmaceuticals, Inc.2013-03-18Not applicableUs
LovastatinTablet20 mg/1OralUnit Dose Services2001-12-17Not applicableUs
LovastatinTablet40 mg/1OralActavis Pharma, Inc.2001-12-17Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
AltocorNot Available
Brand mixtures
NameLabellerIngredients
AdvicorAbb Vie Inc.
SaltsNot Available
Categories
UNII9LHU78OQFD
CAS number75330-75-5
WeightAverage: 404.5396
Monoisotopic: 404.256274262
Chemical FormulaC24H36O5
InChI KeyPCZOHLXUXFIOCF-BXMDZJJMSA-N
InChI
InChI=1S/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18-21,23,25H,5,8-9,11-13H2,1-4H3/t14-,15-,16-,18+,19+,20-,21-,23-/m0/s1
IUPAC Name
(1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate
SMILES
[H][C@]12[[email protected]](C[C@@H](C)C=C1C=C[[email protected]](C)[C@@H]2CC[C@@H]1C[C@@H](O)CC(=O)O1)OC(=O)[C@@H](C)CC
Pharmacology
IndicationFor management as an adjunct to diet to reduce elevated total-C, LDL-C, apo B, and TG levels in patients with primary hypercholesterolemia and mixed dyslipidemia. For primary prevention of coronary heart disease and to slow progression of coronary atherosclerosis in patients with coronary heart disease.
Structured Indications
PharmacodynamicsThe primary cause of cardiovascular disease is atherosclerotic plaque formation. Sustained elevations of cholesterol in the blood increase the risk of cardiovascular disease. Lovastatin lowers hepatic cholesterol synthesis by competitively inhibiting HMG-CoA reductase, the enzyme that catalyzes the rate-limiting step in the cholesterol biosynthesis pathway via the mevalonic acid pathway. Decreased hepatic cholesterol levels causes increased uptake of low density lipoprotein (LDL) cholesterol and reduces cholesterol levels in the circulation. At therapeutic doses, lovastatin decreases serum LDL cholesterol by 29-32%, increases high density lipoprotein (HDL) cholesterol by 4.6-7.3%, and decrease triglyceride levels by 2-12%. HDL cholesterol is thought to confer protective effects against CV disease, whereas high LDL and triglyceride levels are associated with higher risk of disease.
Mechanism of actionLovastatin is structurally similar to the HMG, a substituent of the endogenous substrate of HMG-CoA reductase. Lovastatin is a prodrug that is activated in vivo via hydrolysis of the lactone ring to form the β-hydroxyacid. The hydrolyzed lactone ring mimics the tetrahedral intermediate produced by the reductase allowing the agent to bind to HMG-CoA reductase with 20,000 times greater affinity than its natural substrate. The bicyclic portion of lovastatin binds to the coenzyme A portion of the active site.
TargetKindPharmacological actionActionsOrganismUniProt ID
3-hydroxy-3-methylglutaryl-coenzyme A reductaseProteinyes
inhibitor
HumanP04035 details
Integrin alpha-LProteinno
other/unknown
HumanP20701 details
Histone deacetylase 2Proteinno
other
HumanQ92769 details
Related Articles
AbsorptionStudies suggest that <5% of the oral dose reaches the general circulation as active inhibitors. Time to peak serum concentration is 2-4 hours. Lovastatin undergoes extensive first-pass metabolism so the availability of the drug in the system is low and variable.
Volume of distribution

Lovastatin is able to cross the blood-brain-barrier and placenta.

Protein bindingLovastatin and its β-hydroxyacid metabolites are highly protein bound (>95%).
Metabolism

Lovastatin is hepatically metabolized in which the major active metabolites are the β-hydroxyacid of lovastatin, the 6’-hydroxy derivative, and two additional metabolites.

Route of eliminationLovastatin undergoes extensive first-pass extraction in the liver, its primary site of action, with subsequent excretion of drug equivalents in the bile. 83% of the orally administered dose is excreted in bile and 10% is excreted in urine.
Half life5.3 hours
ClearanceNot Available
ToxicityLD50>1000 mg/kg (orally in mice)
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Lovastatin Action PathwayDrug actionSMP00099
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
1,10-PhenanthrolineThe serum concentration of Lovastatin can be increased when it is combined with 1,10-Phenanthroline.Experimental
3,4-DichloroisocoumarinThe serum concentration of Lovastatin can be increased when it is combined with 3,4-Dichloroisocoumarin.Experimental
4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDEThe serum concentration of Lovastatin can be increased when it is combined with 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE.Experimental
AbirateroneThe metabolism of Abiraterone can be decreased when combined with Lovastatin.Approved
AcebutololThe serum concentration of Acebutolol can be increased when it is combined with Lovastatin.Approved
AceclofenacThe metabolism of Aceclofenac can be decreased when combined with Lovastatin.Approved
AcenocoumarolThe metabolism of Acenocoumarol can be decreased when combined with Lovastatin.Approved
AcetaminophenThe metabolism of Acetaminophen can be decreased when combined with Lovastatin.Approved
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Lovastatin.Approved, Vet Approved
AcipimoxAcipimox may increase the myopathic rhabdomyolysis activities of Lovastatin.Approved
AdinazolamThe metabolism of Adinazolam can be decreased when combined with Lovastatin.Approved
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Lovastatin.Approved
AlbendazoleThe metabolism of Albendazole can be decreased when combined with Lovastatin.Approved, Vet Approved
AlclometasoneThe metabolism of Alclometasone can be decreased when combined with Lovastatin.Approved
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Lovastatin.Experimental
AlfentanilThe metabolism of Alfentanil can be decreased when combined with Lovastatin.Approved, Illicit
AlfuzosinThe metabolism of Alfuzosin can be decreased when combined with Lovastatin.Approved, Investigational
AliskirenThe metabolism of Aliskiren can be decreased when combined with Lovastatin.Approved, Investigational
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Lovastatin.Approved, Investigational
AllylestrenolThe metabolism of Allylestrenol can be decreased when combined with Lovastatin.Approved
AlmotriptanThe metabolism of Almotriptan can be decreased when combined with Lovastatin.Approved, Investigational
AlogliptinThe serum concentration of Lovastatin can be increased when it is combined with Alogliptin.Approved
AlosetronThe metabolism of Alosetron can be decreased when combined with Lovastatin.Approved, Withdrawn
Alpha-1-proteinase inhibitorThe serum concentration of Lovastatin can be increased when it is combined with Alpha-1-proteinase inhibitor.Approved
AlprazolamThe metabolism of Alprazolam can be decreased when combined with Lovastatin.Approved, Illicit, Investigational
Aluminum hydroxideThe serum concentration of Lovastatin can be decreased when it is combined with Aluminum hydroxide.Approved
Aluminum phosphateThe serum concentration of Lovastatin can be decreased when it is combined with Aluminum phosphate.Approved
AmbrisentanThe metabolism of Ambrisentan can be decreased when combined with Lovastatin.Approved, Investigational
AmbroxolThe metabolism of Ambroxol can be decreased when combined with Lovastatin.Approved
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Lovastatin.Approved, Withdrawn
AminophyllineThe metabolism of Aminophylline can be decreased when combined with Lovastatin.Approved
AmiodaroneThe serum concentration of Lovastatin can be increased when it is combined with Amiodarone.Approved, Investigational
AmitriptylineThe metabolism of Amitriptyline can be decreased when combined with Lovastatin.Approved
AmlodipineThe metabolism of Amlodipine can be decreased when combined with Lovastatin.Approved
AmodiaquineThe serum concentration of Amodiaquine can be increased when it is combined with Lovastatin.Approved
AmprenavirThe serum concentration of Lovastatin can be increased when it is combined with Amprenavir.Approved
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Lovastatin.Approved
Antithrombin III humanThe serum concentration of Lovastatin can be increased when it is combined with Antithrombin III human.Approved
ApixabanThe serum concentration of Lovastatin can be increased when it is combined with Apixaban.Approved
ApremilastThe metabolism of Apremilast can be decreased when combined with Lovastatin.Approved, Investigational
AprepitantThe serum concentration of Lovastatin can be increased when it is combined with Aprepitant.Approved, Investigational
AprotininThe serum concentration of Lovastatin can be increased when it is combined with Aprotinin.Approved, Withdrawn
Arachidonic AcidThe metabolism of Arachidonic Acid can be decreased when combined with Lovastatin.Experimental
ArformoterolThe metabolism of Arformoterol can be decreased when combined with Lovastatin.Approved, Investigational
ArgatrobanThe serum concentration of Lovastatin can be increased when it is combined with Argatroban.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Lovastatin.Approved, Investigational
Arsenic trioxideThe serum concentration of Arsenic trioxide can be increased when it is combined with Lovastatin.Approved, Investigational
ArtemetherThe metabolism of Artemether can be decreased when combined with Lovastatin.Approved
AsenapineThe metabolism of Asenapine can be decreased when combined with Lovastatin.Approved
AstemizoleThe metabolism of Astemizole can be decreased when combined with Lovastatin.Approved, Withdrawn
AsunaprevirThe serum concentration of Lovastatin can be increased when it is combined with Asunaprevir.Approved, Investigational
AtazanavirThe serum concentration of Lovastatin can be increased when it is combined with Atazanavir.Approved, Investigational
AtenololThe serum concentration of Atenolol can be increased when it is combined with Lovastatin.Approved
AtomoxetineThe metabolism of Lovastatin can be decreased when combined with Atomoxetine.Approved
AtorvastatinThe metabolism of Atorvastatin can be decreased when combined with Lovastatin.Approved
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Lovastatin.Approved
AxitinibThe metabolism of Axitinib can be decreased when combined with Lovastatin.Approved, Investigational
AzelastineThe metabolism of Azelastine can be decreased when combined with Lovastatin.Approved
AzithromycinThe metabolism of Azithromycin can be decreased when combined with Lovastatin.Approved
AzithromycinAzithromycin may increase the myopathic rhabdomyolysis activities of Lovastatin.Approved
BanoxantroneThe metabolism of Banoxantrone can be decreased when combined with Lovastatin.Investigational
BatimastatThe serum concentration of Lovastatin can be increased when it is combined with Batimastat.Experimental
BedaquilineThe metabolism of Bedaquiline can be decreased when combined with Lovastatin.Approved
BenazeprilThe serum concentration of Lovastatin can be increased when it is combined with Benazepril.Approved, Investigational
BenzamidineThe serum concentration of Lovastatin can be increased when it is combined with Benzamidine.Experimental
BenzphetamineThe metabolism of Benzphetamine can be decreased when combined with Lovastatin.Approved, Illicit
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Lovastatin.Approved
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Lovastatin.Approved, Vet Approved
BexaroteneThe serum concentration of Lovastatin can be decreased when it is combined with Bexarotene.Approved, Investigational
BezafibrateBezafibrate may increase the myopathic rhabdomyolysis activities of Lovastatin.Approved
Bi201335The serum concentration of Lovastatin can be increased when it is combined with Bi201335.Investigational
BicalutamideThe metabolism of Bicalutamide can be decreased when combined with Lovastatin.Approved
Bismuth SubcitrateThe serum concentration of Lovastatin can be decreased when it is combined with Bismuth Subcitrate.Approved
BisoprololThe metabolism of Bisoprolol can be decreased when combined with Lovastatin.Approved
BivalirudinThe serum concentration of Lovastatin can be increased when it is combined with Bivalirudin.Approved, Investigational
BoceprevirThe serum concentration of Lovastatin can be increased when it is combined with Boceprevir.Approved
BortezomibThe metabolism of Lovastatin can be decreased when combined with Bortezomib.Approved, Investigational
BosentanThe metabolism of Lovastatin can be increased when combined with Bosentan.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Lovastatin.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Lovastatin.Approved
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Lovastatin.Approved
BrinzolamideThe metabolism of Brinzolamide can be decreased when combined with Lovastatin.Approved
BromazepamThe metabolism of Bromazepam can be decreased when combined with Lovastatin.Approved, Illicit
BromocriptineThe metabolism of Bromocriptine can be decreased when combined with Lovastatin.Approved, Investigational
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Lovastatin.Approved
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Lovastatin.Approved
BudesonideThe metabolism of Budesonide can be decreased when combined with Lovastatin.Approved
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Lovastatin.Approved, Investigational
BuprenorphineThe metabolism of Buprenorphine can be decreased when combined with Lovastatin.Approved, Illicit, Investigational, Vet Approved
BupropionThe metabolism of Bupropion can be decreased when combined with Lovastatin.Approved
BuspironeThe metabolism of Buspirone can be decreased when combined with Lovastatin.Approved, Investigational
BusulfanThe metabolism of Busulfan can be decreased when combined with Lovastatin.Approved, Investigational
CabazitaxelThe metabolism of Cabazitaxel can be decreased when combined with Lovastatin.Approved
CabergolineThe metabolism of Cabergoline can be decreased when combined with Lovastatin.Approved
CabozantinibThe metabolism of Cabozantinib can be decreased when combined with Lovastatin.Approved
CaffeineThe metabolism of Caffeine can be decreased when combined with Lovastatin.Approved
CalcitriolThe metabolism of Calcitriol can be decreased when combined with Lovastatin.Approved, Nutraceutical
Calcium carbonateThe serum concentration of Lovastatin can be decreased when it is combined with Calcium carbonate.Approved
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Lovastatin.Experimental
CanagliflozinThe metabolism of Canagliflozin can be decreased when combined with Lovastatin.Approved
CandesartanThe metabolism of Candesartan can be decreased when combined with Lovastatin.Approved
CandoxatrilThe serum concentration of Lovastatin can be increased when it is combined with Candoxatril.Experimental
CandoxatrilatThe serum concentration of Lovastatin can be increased when it is combined with Candoxatrilat.Experimental
CaptoprilThe serum concentration of Lovastatin can be increased when it is combined with Captopril.Approved
CarbamazepineThe metabolism of Lovastatin can be increased when combined with Carbamazepine.Approved, Investigational
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Lovastatin.Approved
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Lovastatin.Approved
CariprazineThe metabolism of Cariprazine can be decreased when combined with Lovastatin.Approved
CarvedilolThe serum concentration of Carvedilol can be increased when it is combined with Lovastatin.Approved, Investigational
CelecoxibThe metabolism of Celecoxib can be decreased when combined with Lovastatin.Approved, Investigational
CeliprololThe metabolism of Celiprolol can be decreased when combined with Lovastatin.Approved, Investigational
CephalexinThe metabolism of Cephalexin can be decreased when combined with Lovastatin.Approved, Vet Approved
CeritinibThe serum concentration of Lovastatin can be increased when it is combined with Ceritinib.Approved
CerivastatinThe metabolism of Cerivastatin can be decreased when combined with Lovastatin.Withdrawn
CevimelineThe metabolism of Cevimeline can be decreased when combined with Lovastatin.Approved
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be decreased when combined with Lovastatin.Approved
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Lovastatin.Approved, Illicit
ChloroquineThe metabolism of Chloroquine can be decreased when combined with Lovastatin.Approved, Vet Approved
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Lovastatin.Approved
ChlorpromazineThe metabolism of Chlorpromazine can be decreased when combined with Lovastatin.Approved, Vet Approved
ChlorpropamideThe metabolism of Chlorpropamide can be decreased when combined with Lovastatin.Approved
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Lovastatin.Approved
CholecalciferolThe metabolism of Cholecalciferol can be decreased when combined with Lovastatin.Approved, Nutraceutical
ChymostatinThe serum concentration of Lovastatin can be increased when it is combined with Chymostatin.Experimental
CiclesonideThe metabolism of Ciclesonide can be decreased when combined with Lovastatin.Approved, Investigational
CilastatinThe serum concentration of Lovastatin can be increased when it is combined with Cilastatin.Approved
CilazaprilThe serum concentration of Lovastatin can be increased when it is combined with Cilazapril.Approved
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Lovastatin.Approved
CimetidineThe serum concentration of Cimetidine can be increased when it is combined with Lovastatin.Approved
CinacalcetThe metabolism of Cinacalcet can be decreased when combined with Lovastatin.Approved
CinnarizineThe metabolism of Cinnarizine can be decreased when combined with Lovastatin.Approved
CiprofibrateThe risk or severity of adverse effects can be increased when Ciprofibrate is combined with Lovastatin.Approved
CiprofloxacinThe serum concentration of Ciprofloxacin can be increased when it is combined with Lovastatin.Approved, Investigational
CisaprideThe metabolism of Cisapride can be decreased when combined with Lovastatin.Approved, Investigational, Withdrawn
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Lovastatin.Approved
CitalopramThe metabolism of Citalopram can be decreased when combined with Lovastatin.Approved
ClarithromycinThe serum concentration of Lovastatin can be increased when it is combined with Clarithromycin.Approved
ClemastineThe metabolism of Lovastatin can be decreased when combined with Clemastine.Approved
ClindamycinThe metabolism of Clindamycin can be decreased when combined with Lovastatin.Approved, Vet Approved
ClobazamThe metabolism of Clobazam can be decreased when combined with Lovastatin.Approved, Illicit
ClofazimineThe metabolism of Clofazimine can be decreased when combined with Lovastatin.Approved, Investigational
ClofibrateThe metabolism of Clofibrate can be decreased when combined with Lovastatin.Approved
clomethiazoleThe metabolism of clomethiazole can be decreased when combined with Lovastatin.Investigational
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Lovastatin.Approved, Investigational
ClomipramineThe metabolism of Clomipramine can be decreased when combined with Lovastatin.Approved, Vet Approved
ClonazepamThe metabolism of Clonazepam can be decreased when combined with Lovastatin.Approved, Illicit
ClonidineThe metabolism of Clonidine can be decreased when combined with Lovastatin.Approved
ClopidogrelThe metabolism of Clopidogrel can be decreased when combined with Lovastatin.Approved, Nutraceutical
ClorazepateThe metabolism of Clorazepate can be decreased when combined with Lovastatin.Approved, Illicit
ClotiazepamThe metabolism of Clotiazepam can be decreased when combined with Lovastatin.Approved, Illicit
ClotrimazoleThe metabolism of Lovastatin can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineThe metabolism of Clozapine can be decreased when combined with Lovastatin.Approved
CobicistatThe serum concentration of Lovastatin can be increased when it is combined with Cobicistat.Approved
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Lovastatin.Approved
CocaineThe metabolism of Cocaine can be decreased when combined with Lovastatin.Approved, Illicit
CodeineThe metabolism of Codeine can be decreased when combined with Lovastatin.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Lovastatin.Approved
ConivaptanThe serum concentration of Lovastatin can be increased when it is combined with Conivaptan.Approved, Investigational
Conjugated Equine EstrogensThe metabolism of Conjugated Equine Estrogens can be decreased when combined with Lovastatin.Approved
Cortisone acetateThe metabolism of Cortisone acetate can be decreased when combined with Lovastatin.Approved
CrizotinibThe metabolism of Crizotinib can be decreased when combined with Lovastatin.Approved
CyclobenzaprineThe metabolism of Cyclobenzaprine can be decreased when combined with Lovastatin.Approved
CyclophosphamideThe metabolism of Cyclophosphamide can be decreased when combined with Lovastatin.Approved, Investigational
CyclosporineThe serum concentration of Lovastatin can be increased when it is combined with Cyclosporine.Approved, Investigational, Vet Approved
CyclosporineThe metabolism of Cyclosporine can be decreased when combined with Lovastatin.Approved, Investigational, Vet Approved
Cyproterone acetateThe serum concentration of Lovastatin can be increased when it is combined with Cyproterone acetate.Approved, Investigational
CytarabineThe metabolism of Cytarabine can be decreased when combined with Lovastatin.Approved, Investigational
Dabigatran etexilateThe serum concentration of Lovastatin can be increased when it is combined with Dabigatran etexilate.Approved
DabrafenibThe serum concentration of Lovastatin can be decreased when it is combined with Dabrafenib.Approved
DaclatasvirThe serum concentration of Lovastatin can be increased when it is combined with Daclatasvir.Approved
DactinomycinThe serum concentration of Dactinomycin can be increased when it is combined with Lovastatin.Approved
DanazolThe serum concentration of Lovastatin can be increased when it is combined with Danazol.Approved
DantroleneThe metabolism of Dantrolene can be decreased when combined with Lovastatin.Approved
DapagliflozinThe metabolism of Dapagliflozin can be decreased when combined with Lovastatin.Approved
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Lovastatin.Investigational
DapsoneThe metabolism of Dapsone can be decreased when combined with Lovastatin.Approved, Investigational
DaptomycinThe risk or severity of adverse effects can be increased when Lovastatin is combined with Daptomycin.Approved, Investigational
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Lovastatin.Approved, Investigational
DarunavirThe serum concentration of Lovastatin can be increased when it is combined with Darunavir.Approved
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Lovastatin.Approved
DasatinibThe serum concentration of Lovastatin can be increased when it is combined with Dasatinib.Approved, Investigational
DaunorubicinThe metabolism of Daunorubicin can be decreased when combined with Lovastatin.Approved
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Lovastatin.Approved
DeferasiroxThe serum concentration of Lovastatin can be decreased when it is combined with Deferasirox.Approved, Investigational
DelavirdineThe metabolism of Delavirdine can be decreased when combined with Lovastatin.Approved
DesvenlafaxineThe metabolism of Desvenlafaxine can be decreased when combined with Lovastatin.Approved
DexamethasoneThe serum concentration of Lovastatin can be decreased when it is combined with Dexamethasone.Approved, Investigational, Vet Approved
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Lovastatin.Approved
DextropropoxypheneThe metabolism of Dextropropoxyphene can be decreased when combined with Lovastatin.Approved, Illicit, Withdrawn
DiazepamThe metabolism of Diazepam can be decreased when combined with Lovastatin.Approved, Illicit, Vet Approved
DiclofenacThe metabolism of Diclofenac can be decreased when combined with Lovastatin.Approved, Vet Approved
DicoumarolThe metabolism of Dicoumarol can be decreased when combined with Lovastatin.Approved
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Lovastatin.Approved
DigitoxinThe metabolism of Digitoxin can be decreased when combined with Lovastatin.Approved
DigoxinThe metabolism of Digoxin can be decreased when combined with Lovastatin.Approved
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Lovastatin.Approved, Illicit
DihydroergotamineThe metabolism of Dihydroergotamine can be decreased when combined with Lovastatin.Approved
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Lovastatin.Illicit
DiltiazemThe serum concentration of Diltiazem can be increased when it is combined with Lovastatin.Approved
DiphenhydramineThe metabolism of Diphenhydramine can be decreased when combined with Lovastatin.Approved
DipyridamoleThe serum concentration of Dipyridamole can be increased when it is combined with Lovastatin.Approved
DisopyramideThe metabolism of Disopyramide can be decreased when combined with Lovastatin.Approved
DisulfiramThe metabolism of Disulfiram can be decreased when combined with Lovastatin.Approved
DocetaxelThe metabolism of Docetaxel can be decreased when combined with Lovastatin.Approved, Investigational
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Lovastatin.Approved
DolasetronThe metabolism of Dolasetron can be decreased when combined with Lovastatin.Approved
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Lovastatin.Approved, Investigational, Vet Approved
DonepezilThe metabolism of Donepezil can be decreased when combined with Lovastatin.Approved
DopamineThe metabolism of Dopamine can be decreased when combined with Lovastatin.Approved
DorzolamideThe metabolism of Dorzolamide can be decreased when combined with Lovastatin.Approved
DoxepinThe metabolism of Doxepin can be decreased when combined with Lovastatin.Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Lovastatin.Approved, Investigational
DoxorubicinThe metabolism of Doxorubicin can be decreased when combined with Lovastatin.Approved, Investigational
DoxycyclineThe metabolism of Lovastatin can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Lovastatin.Approved, Illicit
DronedaroneThe serum concentration of Lovastatin can be increased when it is combined with Dronedarone.Approved
DutasterideThe metabolism of Dutasteride can be decreased when combined with Lovastatin.Approved, Investigational
EcabetThe serum concentration of Lovastatin can be increased when it is combined with Ecabet.Approved, Investigational
EdoxabanThe serum concentration of Lovastatin can be increased when it is combined with Edoxaban.Approved
EfavirenzThe serum concentration of Lovastatin can be decreased when it is combined with Efavirenz.Approved, Investigational
ElafinThe serum concentration of Lovastatin can be increased when it is combined with Elafin.Investigational
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Lovastatin.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Lovastatin.Approved
ElvitegravirThe metabolism of Elvitegravir can be decreased when combined with Lovastatin.Approved
EnalaprilThe serum concentration of Lovastatin can be increased when it is combined with Enalapril.Approved, Vet Approved
EnalaprilatThe serum concentration of Lovastatin can be increased when it is combined with Enalaprilat.Approved
EnalkirenThe serum concentration of Lovastatin can be increased when it is combined with Enalkiren.Experimental
EnzalutamideThe serum concentration of Lovastatin can be decreased when it is combined with Enzalutamide.Approved
EpinastineThe metabolism of Epinastine can be decreased when combined with Lovastatin.Approved, Investigational
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Lovastatin.Approved
EpoprostenolThe metabolism of Epoprostenol can be decreased when combined with Lovastatin.Approved
ErgocalciferolThe metabolism of Ergocalciferol can be decreased when combined with Lovastatin.Approved, Nutraceutical
Ergoloid mesylateThe metabolism of Ergoloid mesylate can be decreased when combined with Lovastatin.Approved
ErgonovineThe metabolism of Ergonovine can be decreased when combined with Lovastatin.Approved
ErgotamineThe metabolism of Ergotamine can be decreased when combined with Lovastatin.Approved
ErlotinibThe metabolism of Erlotinib can be decreased when combined with Lovastatin.Approved, Investigational
ErythromycinThe serum concentration of Lovastatin can be increased when it is combined with Erythromycin.Approved, Vet Approved
ErythromycinThe metabolism of Erythromycin can be decreased when combined with Lovastatin.Approved, Vet Approved
EscitalopramThe metabolism of Escitalopram can be decreased when combined with Lovastatin.Approved, Investigational
Eslicarbazepine acetateThe serum concentration of Lovastatin can be decreased when it is combined with Eslicarbazepine acetate.Approved
EsomeprazoleThe metabolism of Esomeprazole can be decreased when combined with Lovastatin.Approved, Investigational
EstazolamThe metabolism of Estazolam can be decreased when combined with Lovastatin.Approved, Illicit
EstradiolThe metabolism of Estradiol can be decreased when combined with Lovastatin.Approved, Investigational, Vet Approved
Estradiol valerate/DienogestThe metabolism of Estradiol valerate/Dienogest can be decreased when combined with Lovastatin.Approved
EstramustineThe metabolism of Estramustine can be decreased when combined with Lovastatin.Approved
EstriolThe serum concentration of Estriol can be increased when it is combined with Lovastatin.Approved, Vet Approved
EstroneThe metabolism of Estrone can be decreased when combined with Lovastatin.Approved
Estrone sulfateThe metabolism of Estrone sulfate can be decreased when combined with Lovastatin.Approved
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Lovastatin.Approved
EthanolThe metabolism of Ethanol can be decreased when combined with Lovastatin.Approved
Ethinyl EstradiolThe metabolism of Ethinyl Estradiol can be decreased when combined with Lovastatin.Approved
EthosuximideThe metabolism of Ethosuximide can be decreased when combined with Lovastatin.Approved
Ethyl biscoumacetateLovastatin may increase the anticoagulant activities of Ethyl biscoumacetate.Withdrawn
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Lovastatin.Approved, Illicit
EtodolacThe metabolism of Etodolac can be decreased when combined with Lovastatin.Approved, Investigational, Vet Approved
EtonogestrelThe metabolism of Etonogestrel can be decreased when combined with Lovastatin.Approved, Investigational
EtoposideThe metabolism of Etoposide can be decreased when combined with Lovastatin.Approved
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Lovastatin.Approved, Investigational
EtravirineThe serum concentration of Lovastatin can be decreased when it is combined with Etravirine.Approved
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Lovastatin.Approved
ExemestaneThe metabolism of Exemestane can be decreased when combined with Lovastatin.Approved, Investigational
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Lovastatin.Approved
FamciclovirThe metabolism of Famciclovir can be decreased when combined with Lovastatin.Approved
FelbamateThe metabolism of Felbamate can be decreased when combined with Lovastatin.Approved
FelodipineThe metabolism of Felodipine can be decreased when combined with Lovastatin.Approved, Investigational
FenofibrateThe metabolism of Fenofibrate can be decreased when combined with Lovastatin.Approved
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Lovastatin.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Lovastatin.Approved
FexofenadineThe serum concentration of Fexofenadine can be increased when it is combined with Lovastatin.Approved
FidaxomicinThe serum concentration of Fidaxomicin can be increased when it is combined with Lovastatin.Approved
FinasterideThe metabolism of Finasteride can be decreased when combined with Lovastatin.Approved
FingolimodThe metabolism of Fingolimod can be decreased when combined with Lovastatin.Approved, Investigational
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Lovastatin.Approved
FluconazoleThe serum concentration of Lovastatin can be increased when it is combined with Fluconazole.Approved
FluindioneLovastatin may increase the anticoagulant activities of Fluindione.Investigational
FlunarizineThe metabolism of Flunarizine can be decreased when combined with Lovastatin.Approved
FlunisolideThe metabolism of Flunisolide can be decreased when combined with Lovastatin.Approved, Investigational
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Lovastatin.Approved, Illicit
FluorometholoneThe metabolism of Fluorometholone can be decreased when combined with Lovastatin.Approved
FluoxetineThe metabolism of Fluoxetine can be decreased when combined with Lovastatin.Approved, Vet Approved
FlurazepamThe metabolism of Flurazepam can be decreased when combined with Lovastatin.Approved, Illicit
FlurbiprofenThe metabolism of Flurbiprofen can be decreased when combined with Lovastatin.Approved, Investigational
FlutamideThe metabolism of Flutamide can be decreased when combined with Lovastatin.Approved
Fluticasone furoateThe metabolism of Fluticasone furoate can be decreased when combined with Lovastatin.Approved
Fluticasone PropionateThe metabolism of Fluticasone Propionate can be decreased when combined with Lovastatin.Approved
FluvastatinThe metabolism of Fluvastatin can be decreased when combined with Lovastatin.Approved
FluvoxamineThe metabolism of Lovastatin can be decreased when combined with Fluvoxamine.Approved, Investigational
FormoterolThe metabolism of Formoterol can be decreased when combined with Lovastatin.Approved, Investigational
FosamprenavirThe serum concentration of Lovastatin can be increased when it is combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Lovastatin can be increased when it is combined with Fosaprepitant.Approved
FosinoprilThe serum concentration of Lovastatin can be increased when it is combined with Fosinopril.Approved
FosphenytoinThe serum concentration of Lovastatin can be decreased when it is combined with Fosphenytoin.Approved
FulvestrantThe metabolism of Fulvestrant can be decreased when combined with Lovastatin.Approved, Investigational
Fusidic AcidThe serum concentration of Lovastatin can be increased when it is combined with Fusidic Acid.Approved
GabexateThe serum concentration of Lovastatin can be increased when it is combined with Gabexate.Investigational
GalantamineThe metabolism of Galantamine can be decreased when combined with Lovastatin.Approved
GavestinelThe metabolism of Gavestinel can be decreased when combined with Lovastatin.Investigational
GefitinibThe metabolism of Gefitinib can be decreased when combined with Lovastatin.Approved, Investigational
GeldanamycinThe serum concentration of Lovastatin can be increased when it is combined with Geldanamycin.Experimental
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Lovastatin.Approved
GemfibrozilGemfibrozil may increase the myopathic rhabdomyolysis activities of Lovastatin.Approved
GliclazideThe metabolism of Gliclazide can be decreased when combined with Lovastatin.Approved
GlimepirideThe metabolism of Glimepiride can be decreased when combined with Lovastatin.Approved
GlipizideThe metabolism of Glipizide can be decreased when combined with Lovastatin.Approved
GlyburideThe metabolism of Glyburide can be decreased when combined with Lovastatin.Approved
GM6001The serum concentration of Lovastatin can be increased when it is combined with GM6001.Experimental
GranisetronThe metabolism of Granisetron can be decreased when combined with Lovastatin.Approved, Investigational
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Lovastatin.Approved
GrepafloxacinThe metabolism of Grepafloxacin can be decreased when combined with Lovastatin.Withdrawn
GuanfacineThe metabolism of Guanfacine can be decreased when combined with Lovastatin.Approved, Investigational
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Lovastatin.Approved
HaloperidolThe metabolism of Haloperidol can be decreased when combined with Lovastatin.Approved
HalothaneThe metabolism of Halothane can be decreased when combined with Lovastatin.Approved, Vet Approved
HexobarbitalThe metabolism of Hexobarbital can be decreased when combined with Lovastatin.Approved
HirulogThe serum concentration of Lovastatin can be increased when it is combined with Hirulog.Experimental
Histamine PhosphateThe metabolism of Histamine Phosphate can be decreased when combined with Lovastatin.Approved
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Lovastatin.Approved, Illicit
HydrocortisoneThe metabolism of Hydrocortisone can be decreased when combined with Lovastatin.Approved, Vet Approved
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Lovastatin.Approved, Illicit
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be decreased when combined with Lovastatin.Approved
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Lovastatin.Approved
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Lovastatin.Approved
IdarubicinThe metabolism of Idarubicin can be decreased when combined with Lovastatin.Approved
IdelalisibThe serum concentration of Lovastatin can be increased when it is combined with Idelalisib.Approved
idraparinuxThe serum concentration of Lovastatin can be increased when it is combined with idraparinux.Investigational
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Lovastatin resulting in a loss in efficacy.Approved
IloperidoneThe metabolism of Iloperidone can be decreased when combined with Lovastatin.Approved
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Lovastatin.Approved
ImidaprilThe serum concentration of Lovastatin can be increased when it is combined with Imidapril.Investigational
ImipramineThe metabolism of Imipramine can be decreased when combined with Lovastatin.Approved
ImiquimodThe metabolism of Imiquimod can be decreased when combined with Lovastatin.Approved, Investigational
IndacaterolThe metabolism of Indacaterol can be decreased when combined with Lovastatin.Approved
IndapamideThe metabolism of Indapamide can be decreased when combined with Lovastatin.Approved
IndinavirThe serum concentration of Lovastatin can be increased when it is combined with Indinavir.Approved
indisulamThe metabolism of indisulam can be decreased when combined with Lovastatin.Investigational
IndomethacinThe serum concentration of Indomethacin can be increased when it is combined with Lovastatin.Approved, Investigational
Ipratropium bromideThe metabolism of Ipratropium bromide can be decreased when combined with Lovastatin.Approved
IrbesartanThe metabolism of Irbesartan can be decreased when combined with Lovastatin.Approved, Investigational
IrinotecanThe metabolism of Irinotecan can be decreased when combined with Lovastatin.Approved, Investigational
IsavuconazoniumThe metabolism of Isavuconazonium can be decreased when combined with Lovastatin.Approved, Investigational
IsoflurophateThe serum concentration of Lovastatin can be increased when it is combined with Isoflurophate.Approved, Withdrawn
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be decreased when combined with Lovastatin.Approved
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be decreased when combined with Lovastatin.Approved
IsradipineThe metabolism of Isradipine can be decreased when combined with Lovastatin.Approved
ItraconazoleThe serum concentration of Lovastatin can be increased when it is combined with Itraconazole.Approved, Investigational
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Lovastatin.Approved
IvacaftorThe serum concentration of Ivacaftor can be increased when it is combined with Lovastatin.Approved
IvermectinThe metabolism of Ivermectin can be decreased when combined with Lovastatin.Approved, Vet Approved
IxabepiloneThe metabolism of Ixabepilone can be decreased when combined with Lovastatin.Approved, Investigational
IxazomibThe serum concentration of Lovastatin can be increased when it is combined with Ixazomib.Approved
KetamineThe metabolism of Ketamine can be decreased when combined with Lovastatin.Approved, Vet Approved
KetazolamThe metabolism of Ketazolam can be decreased when combined with Lovastatin.Approved
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Lovastatin.Approved
KetoconazoleThe serum concentration of Lovastatin can be increased when it is combined with Ketoconazole.Approved, Investigational
KetoprofenThe metabolism of Ketoprofen can be decreased when combined with Lovastatin.Approved, Vet Approved
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Lovastatin.Approved, Investigational
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Lovastatin.Approved, Investigational
LansoprazoleThe metabolism of Lansoprazole can be decreased when combined with Lovastatin.Approved, Investigational
Lanthanum carbonateThe serum concentration of Lanthanum carbonate can be decreased when it is combined with Lovastatin.Approved
LapatinibThe metabolism of Lapatinib can be decreased when combined with Lovastatin.Approved, Investigational
LaquinimodThe metabolism of Laquinimod can be decreased when combined with Lovastatin.Investigational
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Lovastatin.Approved
LeflunomideThe metabolism of Leflunomide can be decreased when combined with Lovastatin.Approved, Investigational
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Lovastatin.Approved
LenvatinibThe metabolism of Lenvatinib can be decreased when combined with Lovastatin.Approved
LepirudinThe serum concentration of Lovastatin can be increased when it is combined with Lepirudin.Approved
LercanidipineThe metabolism of Lercanidipine can be decreased when combined with Lovastatin.Approved, Investigational
LesinuradThe metabolism of Lesinurad can be decreased when combined with Lovastatin.Approved
LetrozoleThe metabolism of Letrozole can be decreased when combined with Lovastatin.Approved, Investigational
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Lovastatin.Approved, Investigational
LevobupivacaineThe metabolism of Levobupivacaine can be decreased when combined with Lovastatin.Approved
LevocetirizineThe metabolism of Levocetirizine can be decreased when combined with Lovastatin.Approved
LevofloxacinThe serum concentration of Levofloxacin can be increased when it is combined with Lovastatin.Approved, Investigational
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be decreased when combined with Lovastatin.Approved
LevomilnacipranThe metabolism of Levomilnacipran can be decreased when combined with Lovastatin.Approved
LevonorgestrelThe metabolism of Levonorgestrel can be decreased when combined with Lovastatin.Approved, Investigational
LevothyroxineThe metabolism of Levothyroxine can be decreased when combined with Lovastatin.Approved
LicofeloneThe metabolism of Licofelone can be decreased when combined with Lovastatin.Investigational
LidocaineThe metabolism of Lidocaine can be decreased when combined with Lovastatin.Approved, Vet Approved
LinagliptinThe serum concentration of Lovastatin can be increased when it is combined with Linagliptin.Approved
LisinoprilThe serum concentration of Lovastatin can be increased when it is combined with Lisinopril.Approved, Investigational
LisurideThe metabolism of Lisuride can be decreased when combined with Lovastatin.Approved
LomitapideThe serum concentration of Lovastatin can be increased when it is combined with Lomitapide.Approved
LoperamideThe metabolism of Loperamide can be decreased when combined with Lovastatin.Approved
LopinavirThe serum concentration of Lovastatin can be increased when it is combined with Lopinavir.Approved
LoratadineThe metabolism of Loratadine can be decreased when combined with Lovastatin.Approved
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Lovastatin.Approved
LornoxicamThe metabolism of Lornoxicam can be decreased when combined with Lovastatin.Approved
LosartanThe metabolism of Losartan can be decreased when combined with Lovastatin.Approved
LuliconazoleThe serum concentration of Lovastatin can be increased when it is combined with Luliconazole.Approved
LumacaftorThe metabolism of Lovastatin can be increased when combined with Lumacaftor.Approved
LumefantrineThe metabolism of Lumefantrine can be decreased when combined with Lovastatin.Approved
LumiracoxibThe metabolism of Lumiracoxib can be decreased when combined with Lovastatin.Approved, Investigational
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Lovastatin.Approved
MacitentanThe metabolism of Macitentan can be decreased when combined with Lovastatin.Approved
MagaldrateThe serum concentration of Lovastatin can be decreased when it is combined with Magaldrate.Withdrawn
Magnesium carbonateThe serum concentration of Lovastatin can be decreased when it is combined with Magnesium carbonate.Approved
Magnesium hydroxideThe serum concentration of Lovastatin can be decreased when it is combined with Magnesium hydroxide.Approved
Magnesium oxideThe serum concentration of Lovastatin can be decreased when it is combined with Magnesium oxide.Approved
Magnesium TrisilicateThe serum concentration of Lovastatin can be decreased when it is combined with Magnesium Trisilicate.Approved
MannitolThe serum concentration of Mannitol can be increased when it is combined with Lovastatin.Approved, Investigational
MaravirocThe metabolism of Maraviroc can be decreased when combined with Lovastatin.Approved, Investigational
MebendazoleThe metabolism of Mebendazole can be decreased when combined with Lovastatin.Approved, Vet Approved
Medroxyprogesterone acetateThe metabolism of Medroxyprogesterone acetate can be decreased when combined with Lovastatin.Approved, Investigational
Mefenamic acidThe metabolism of Mefenamic acid can be decreased when combined with Lovastatin.Approved
MefloquineThe metabolism of Mefloquine can be decreased when combined with Lovastatin.Approved
MelatoninThe metabolism of Melatonin can be decreased when combined with Lovastatin.Approved, Nutraceutical, Vet Approved
MeloxicamThe metabolism of Meloxicam can be decreased when combined with Lovastatin.Approved, Vet Approved
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Lovastatin.Investigational, Withdrawn
MestranolThe metabolism of Mestranol can be decreased when combined with Lovastatin.Approved
MethadoneThe metabolism of Methadone can be decreased when combined with Lovastatin.Approved
MethaqualoneThe metabolism of Methaqualone can be decreased when combined with Lovastatin.Illicit, Withdrawn
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Lovastatin.Approved
MethoxsalenThe metabolism of Methoxsalen can be decreased when combined with Lovastatin.Approved
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Lovastatin.Approved, Vet Approved
MethylprednisoloneThe metabolism of Methylprednisolone can be decreased when combined with Lovastatin.Approved, Vet Approved
MethyltestosteroneThe metabolism of Methyltestosterone can be decreased when combined with Lovastatin.Approved
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Lovastatin.Approved, Investigational
MetronidazoleThe metabolism of Metronidazole can be decreased when combined with Lovastatin.Approved
MexiletineThe metabolism of Mexiletine can be decreased when combined with Lovastatin.Approved
MianserinThe metabolism of Mianserin can be decreased when combined with Lovastatin.Approved
MibefradilThe metabolism of Mibefradil can be decreased when combined with Lovastatin.Withdrawn
MiconazoleThe metabolism of Miconazole can be decreased when combined with Lovastatin.Approved, Investigational, Vet Approved
MidazolamThe metabolism of Midazolam can be decreased when combined with Lovastatin.Approved, Illicit
MifepristoneThe serum concentration of Lovastatin can be increased when it is combined with Mifepristone.Approved, Investigational
MirabegronThe metabolism of Mirabegron can be decreased when combined with Lovastatin.Approved
MirtazapineThe metabolism of Mirtazapine can be decreased when combined with Lovastatin.Approved
MitotaneThe serum concentration of Lovastatin can be decreased when it is combined with Mitotane.Approved
MitoxantroneThe serum concentration of Mitoxantrone can be increased when it is combined with Lovastatin.Approved, Investigational
MoclobemideThe metabolism of Moclobemide can be decreased when combined with Lovastatin.Approved
ModafinilThe serum concentration of Lovastatin can be decreased when it is combined with Modafinil.Approved, Investigational
MoexiprilThe serum concentration of Lovastatin can be increased when it is combined with Moexipril.Approved
MontelukastThe metabolism of Montelukast can be decreased when combined with Lovastatin.Approved
MorphineThe metabolism of Morphine can be decreased when combined with Lovastatin.Approved, Investigational
Mycophenolate mofetilThe metabolism of Mycophenolate mofetil can be decreased when combined with Lovastatin.Approved, Investigational
N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-ProlineThe serum concentration of Lovastatin can be increased when it is combined with N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-Proline.Experimental
NadololThe serum concentration of Nadolol can be increased when it is combined with Lovastatin.Approved
NafamostatThe serum concentration of Lovastatin can be increased when it is combined with Nafamostat.Investigational
NafcillinThe serum concentration of Lovastatin can be decreased when it is combined with Nafcillin.Approved
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Lovastatin.Approved
NaloxoneThe metabolism of Naloxone can be decreased when combined with Lovastatin.Approved, Vet Approved
NaproxenThe metabolism of Naproxen can be decreased when combined with Lovastatin.Approved, Vet Approved
NateglinideThe metabolism of Nateglinide can be decreased when combined with Lovastatin.Approved, Investigational
NCX 4016The serum concentration of Lovastatin can be increased when it is combined with NCX 4016.Investigational
NefazodoneThe serum concentration of Lovastatin can be increased when it is combined with Nefazodone.Approved, Withdrawn
NelfinavirThe serum concentration of Lovastatin can be increased when it is combined with Nelfinavir.Approved
NetupitantThe serum concentration of Lovastatin can be increased when it is combined with Netupitant.Approved
NevirapineThe metabolism of Lovastatin can be increased when combined with Nevirapine.Approved
NiacinThe risk or severity of adverse effects can be increased when Niacin is combined with Lovastatin.Approved, Investigational, Nutraceutical
NicardipineThe metabolism of Nicardipine can be decreased when combined with Lovastatin.Approved
NiclosamideThe metabolism of Niclosamide can be decreased when combined with Lovastatin.Approved, Vet Approved
NicotinamideThe risk or severity of adverse effects can be increased when Nicotinamide is combined with Lovastatin.Approved
NicotineThe metabolism of Nicotine can be decreased when combined with Lovastatin.Approved
NifedipineThe metabolism of Nifedipine can be decreased when combined with Lovastatin.Approved
NilotinibThe metabolism of Nilotinib can be decreased when combined with Lovastatin.Approved, Investigational
NilvadipineThe metabolism of Nilvadipine can be decreased when combined with Lovastatin.Approved
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Lovastatin.Approved
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Lovastatin.Approved
NisoldipineThe metabolism of Nisoldipine can be decreased when combined with Lovastatin.Approved
NitrazepamThe metabolism of Nitrazepam can be decreased when combined with Lovastatin.Approved
NitrendipineThe metabolism of Nitrendipine can be decreased when combined with Lovastatin.Approved
NitroaspirinThe serum concentration of Lovastatin can be increased when it is combined with Nitroaspirin.Investigational
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Lovastatin.Approved
NorethisteroneThe metabolism of Norethisterone can be decreased when combined with Lovastatin.Approved
NorgestrelThe metabolism of Norgestrel can be decreased when combined with Lovastatin.Approved
NortriptylineThe metabolism of Nortriptyline can be decreased when combined with Lovastatin.Approved
OlanzapineThe serum concentration of Olanzapine can be increased when it is combined with Lovastatin.Approved, Investigational
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Lovastatin.Approved
OlodaterolThe metabolism of Olodaterol can be decreased when combined with Lovastatin.Approved
OlopatadineThe metabolism of Olopatadine can be decreased when combined with Lovastatin.Approved
OmapatrilatThe serum concentration of Lovastatin can be increased when it is combined with Omapatrilat.Investigational
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Lovastatin.Approved
OmeprazoleThe metabolism of Omeprazole can be decreased when combined with Lovastatin.Approved, Investigational, Vet Approved
OndansetronThe metabolism of Ondansetron can be decreased when combined with Lovastatin.Approved
OrphenadrineThe metabolism of Orphenadrine can be decreased when combined with Lovastatin.Approved
OsimertinibThe serum concentration of Lovastatin can be increased when it is combined with Osimertinib.Approved
OspemifeneThe metabolism of Ospemifene can be decreased when combined with Lovastatin.Approved
OtamixabanThe serum concentration of Lovastatin can be increased when it is combined with Otamixaban.Investigational
OxaprozinThe metabolism of Oxaprozin can be decreased when combined with Lovastatin.Approved
OxazepamThe metabolism of Oxazepam can be decreased when combined with Lovastatin.Approved
OxybutyninThe metabolism of Oxybutynin can be decreased when combined with Lovastatin.Approved, Investigational
OxycodoneThe risk or severity of adverse effects can be increased when Lovastatin is combined with Oxycodone.Approved, Illicit, Investigational
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Lovastatin.Approved, Investigational, Vet Approved
PaclitaxelThe metabolism of Paclitaxel can be decreased when combined with Lovastatin.Approved, Vet Approved
PalbociclibThe serum concentration of Lovastatin can be increased when it is combined with Palbociclib.Approved
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Lovastatin.Approved, Investigational
PanobinostatThe metabolism of Panobinostat can be decreased when combined with Lovastatin.Approved, Investigational
PantoprazoleThe metabolism of Pantoprazole can be decreased when combined with Lovastatin.Approved
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Lovastatin.Approved
ParamethasoneThe metabolism of Paramethasone can be decreased when combined with Lovastatin.Approved
ParecoxibThe metabolism of Parecoxib can be decreased when combined with Lovastatin.Approved
ParicalcitolThe metabolism of Paricalcitol can be decreased when combined with Lovastatin.Approved, Investigational
ParitaprevirThe metabolism of Paritaprevir can be decreased when combined with Lovastatin.Approved
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Lovastatin.Approved
PentamidineThe metabolism of Pentamidine can be decreased when combined with Lovastatin.Approved
PentobarbitalThe metabolism of Lovastatin can be increased when combined with Pentobarbital.Approved, Vet Approved
PerampanelThe metabolism of Perampanel can be decreased when combined with Lovastatin.Approved
PergolideThe metabolism of Pergolide can be decreased when combined with Lovastatin.Approved, Vet Approved, Withdrawn
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Lovastatin.Approved
PerindoprilThe serum concentration of Lovastatin can be increased when it is combined with Perindopril.Approved
PermethrinThe metabolism of Permethrin can be decreased when combined with Lovastatin.Approved, Investigational
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Lovastatin.Approved
PethidineThe metabolism of Pethidine can be decreased when combined with Lovastatin.Approved
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Lovastatin.Withdrawn
PhenindioneLovastatin may increase the anticoagulant activities of Phenindione.Approved
PhenobarbitalThe metabolism of Lovastatin can be increased when combined with Phenobarbital.Approved
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be decreased when combined with Lovastatin.Approved
PhenprocoumonThe metabolism of Phenprocoumon can be decreased when combined with Lovastatin.Approved
PhenylbutazoneThe metabolism of Phenylbutazone can be decreased when combined with Lovastatin.Approved, Vet Approved
PhenytoinThe serum concentration of Lovastatin can be decreased when it is combined with Phenytoin.Approved, Vet Approved
PhosphoramidonThe serum concentration of Lovastatin can be increased when it is combined with Phosphoramidon.Experimental
PilocarpineThe metabolism of Pilocarpine can be decreased when combined with Lovastatin.Approved
PimecrolimusThe metabolism of Pimecrolimus can be decreased when combined with Lovastatin.Approved, Investigational
PimozideThe serum concentration of Pimozide can be increased when it is combined with Lovastatin.Approved
PinacidilThe metabolism of Pinacidil can be decreased when combined with Lovastatin.Withdrawn
PioglitazoneThe metabolism of Pioglitazone can be decreased when combined with Lovastatin.Approved, Investigational
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Lovastatin.Approved
PiroxicamThe metabolism of Piroxicam can be decreased when combined with Lovastatin.Approved, Investigational
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Lovastatin.Approved
PodofiloxThe metabolism of Podofilox can be decreased when combined with Lovastatin.Approved
PomalidomideThe metabolism of Pomalidomide can be decreased when combined with Lovastatin.Approved
PonatinibThe metabolism of Ponatinib can be decreased when combined with Lovastatin.Approved
PosaconazoleThe serum concentration of Lovastatin can be increased when it is combined with Posaconazole.Approved, Investigational, Vet Approved
PrasteroneThe metabolism of Prasterone can be decreased when combined with Lovastatin.Approved, Nutraceutical
PrasugrelThe metabolism of Prasugrel can be decreased when combined with Lovastatin.Approved
PravastatinThe metabolism of Pravastatin can be decreased when combined with Lovastatin.Approved
PrazepamThe metabolism of Prazepam can be decreased when combined with Lovastatin.Approved, Illicit
PraziquantelThe metabolism of Praziquantel can be decreased when combined with Lovastatin.Approved, Vet Approved
PrazosinThe serum concentration of Prazosin can be increased when it is combined with Lovastatin.Approved
PrednisoloneThe metabolism of Prednisolone can be decreased when combined with Lovastatin.Approved, Vet Approved
PrednisoneThe metabolism of Prednisone can be decreased when combined with Lovastatin.Approved, Vet Approved
PrimaquineThe metabolism of Primaquine can be decreased when combined with Lovastatin.Approved
PrimidoneThe metabolism of Lovastatin can be increased when combined with Primidone.Approved, Vet Approved
PrinomastatThe serum concentration of Lovastatin can be increased when it is combined with Prinomastat.Investigational
ProchlorperazineThe metabolism of Prochlorperazine can be decreased when combined with Lovastatin.Approved, Vet Approved
ProgesteroneThe metabolism of Progesterone can be decreased when combined with Lovastatin.Approved, Vet Approved
ProguanilThe metabolism of Proguanil can be decreased when combined with Lovastatin.Approved
PromazineThe metabolism of Promazine can be decreased when combined with Lovastatin.Approved, Vet Approved
PropafenoneThe serum concentration of Propafenone can be increased when it is combined with Lovastatin.Approved
PropofolThe metabolism of Propofol can be decreased when combined with Lovastatin.Approved, Investigational, Vet Approved
PropranololThe metabolism of Propranolol can be decreased when combined with Lovastatin.Approved, Investigational
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Lovastatin.Approved
PyrazinamideThe metabolism of Pyrazinamide can be decreased when combined with Lovastatin.Approved
QuazepamThe metabolism of Quazepam can be decreased when combined with Lovastatin.Approved, Illicit
QuetiapineThe metabolism of Quetiapine can be decreased when combined with Lovastatin.Approved
QuinacrineThe metabolism of Quinacrine can be decreased when combined with Lovastatin.Approved
QuinaprilThe serum concentration of Lovastatin can be increased when it is combined with Quinapril.Approved, Investigational
QuinidineThe metabolism of Quinidine can be decreased when combined with Lovastatin.Approved
QuinineThe serum concentration of Lovastatin can be increased when it is combined with Quinine.Approved
RabeprazoleThe metabolism of Rabeprazole can be decreased when combined with Lovastatin.Approved, Investigational
RacecadotrilThe serum concentration of Lovastatin can be increased when it is combined with Racecadotril.Investigational
RaloxifeneThe metabolism of Raloxifene can be decreased when combined with Lovastatin.Approved, Investigational
RaltegravirRaltegravir may increase the myopathic rhabdomyolysis activities of Lovastatin.Approved
RamelteonThe metabolism of Ramelteon can be decreased when combined with Lovastatin.Approved, Investigational
RamiprilThe serum concentration of Lovastatin can be increased when it is combined with Ramipril.Approved
RanitidineThe serum concentration of Ranitidine can be increased when it is combined with Lovastatin.Approved
RanolazineRanolazine may increase the myopathic rhabdomyolysis activities of Lovastatin.Approved, Investigational
ReboxetineThe metabolism of Reboxetine can be decreased when combined with Lovastatin.Approved, Investigational
RegorafenibThe metabolism of Regorafenib can be decreased when combined with Lovastatin.Approved
RemikirenThe serum concentration of Lovastatin can be increased when it is combined with Remikiren.Approved
RepaglinideThe metabolism of Repaglinide can be decreased when combined with Lovastatin.Approved, Investigational
ReserpineThe serum concentration of Reserpine can be increased when it is combined with Lovastatin.Approved
RetapamulinThe metabolism of Retapamulin can be decreased when combined with Lovastatin.Approved
RifabutinThe metabolism of Lovastatin can be increased when combined with Rifabutin.Approved
RifampicinThe metabolism of Lovastatin can be increased when combined with Rifampicin.Approved
RifapentineThe metabolism of Lovastatin can be increased when combined with Rifapentine.Approved
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Lovastatin.Approved, Investigational
RilpivirineThe metabolism of Rilpivirine can be decreased when combined with Lovastatin.Approved
RimonabantThe metabolism of Rimonabant can be decreased when combined with Lovastatin.Approved, Investigational
RiociguatThe metabolism of Riociguat can be decreased when combined with Lovastatin.Approved
RisperidoneThe metabolism of Risperidone can be decreased when combined with Lovastatin.Approved, Investigational
RitonavirThe serum concentration of Lovastatin can be increased when it is combined with Ritonavir.Approved, Investigational
RivaroxabanThe serum concentration of Lovastatin can be increased when it is combined with Rivaroxaban.Approved
RofecoxibThe metabolism of Rofecoxib can be decreased when combined with Lovastatin.Investigational, Withdrawn
RolapitantThe metabolism of Rolapitant can be decreased when combined with Lovastatin.Approved
RomidepsinThe metabolism of Romidepsin can be decreased when combined with Lovastatin.Approved, Investigational
RopiniroleThe metabolism of Ropinirole can be decreased when combined with Lovastatin.Approved, Investigational
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Lovastatin.Approved
RosiglitazoneThe metabolism of Rosiglitazone can be decreased when combined with Lovastatin.Approved, Investigational
RosuvastatinThe metabolism of Rosuvastatin can be decreased when combined with Lovastatin.Approved
RotigotineThe metabolism of Rotigotine can be decreased when combined with Lovastatin.Approved
RoxithromycinThe metabolism of Roxithromycin can be decreased when combined with Lovastatin.Approved, Withdrawn
RuxolitinibThe metabolism of Ruxolitinib can be decreased when combined with Lovastatin.Approved
Salicylic acidThe serum concentration of Salicylic acid can be increased when it is combined with Lovastatin.Approved, Vet Approved
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Lovastatin.Approved
SaquinavirThe serum concentration of Lovastatin can be increased when it is combined with Saquinavir.Approved, Investigational
SaxagliptinThe serum concentration of Lovastatin can be increased when it is combined with Saxagliptin.Approved
SelegilineThe metabolism of Selegiline can be decreased when combined with Lovastatin.Approved, Investigational, Vet Approved
SelexipagThe metabolism of Selexipag can be decreased when combined with Lovastatin.Approved
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Lovastatin.Approved, Investigational
SertindoleThe metabolism of Sertindole can be decreased when combined with Lovastatin.Approved, Withdrawn
SertralineThe metabolism of Sertraline can be decreased when combined with Lovastatin.Approved
SevofluraneThe metabolism of Sevoflurane can be decreased when combined with Lovastatin.Approved, Vet Approved
SibutramineThe metabolism of Sibutramine can be decreased when combined with Lovastatin.Approved, Illicit, Investigational, Withdrawn
SildenafilThe metabolism of Sildenafil can be decreased when combined with Lovastatin.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Lovastatin.Approved
SiltuximabThe serum concentration of Lovastatin can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Lovastatin can be increased when it is combined with Simeprevir.Approved
SimvastatinThe metabolism of Simvastatin can be decreased when combined with Lovastatin.Approved
SirolimusThe metabolism of Sirolimus can be decreased when combined with Lovastatin.Approved, Investigational
SitagliptinThe serum concentration of Lovastatin can be increased when it is combined with Sitagliptin.Approved, Investigational
SitaxentanThe metabolism of Sitaxentan can be decreased when combined with Lovastatin.Approved, Investigational, Withdrawn
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Lovastatin.Approved
SolifenacinThe metabolism of Solifenacin can be decreased when combined with Lovastatin.Approved
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Lovastatin.Approved, Investigational
SorafenibThe metabolism of Sorafenib can be decreased when combined with Lovastatin.Approved, Investigational
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Lovastatin.Approved
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Lovastatin.Experimental
SpiramycinThe metabolism of Spiramycin can be decreased when combined with Lovastatin.Approved
SpiraprilThe serum concentration of Lovastatin can be increased when it is combined with Spirapril.Approved
St. John's WortThe metabolism of Lovastatin can be increased when combined with St. John&#39;s Wort.Nutraceutical
StiripentolThe serum concentration of Lovastatin can be increased when it is combined with Stiripentol.Approved
SufentanilThe metabolism of Sufentanil can be decreased when combined with Lovastatin.Approved, Investigational
SulfadiazineThe metabolism of Sulfadiazine can be decreased when combined with Lovastatin.Approved, Vet Approved
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be decreased when combined with Lovastatin.Approved
SulfamoxoleThe metabolism of Sulfamoxole can be decreased when combined with Lovastatin.Approved
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be decreased when combined with Lovastatin.Approved
SulfisoxazoleThe metabolism of Lovastatin can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
SunitinibThe metabolism of Sunitinib can be decreased when combined with Lovastatin.Approved, Investigational
SuprofenThe metabolism of Suprofen can be decreased when combined with Lovastatin.Approved, Withdrawn
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Lovastatin.Approved
Synthetic Conjugated Estrogens, AThe metabolism of Synthetic Conjugated Estrogens, A can be decreased when combined with Lovastatin.Approved
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be decreased when combined with Lovastatin.Approved
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Lovastatin.Approved, Investigational
TadalafilThe metabolism of Tadalafil can be decreased when combined with Lovastatin.Approved, Investigational
TamoxifenThe metabolism of Tamoxifen can be decreased when combined with Lovastatin.Approved
TamsulosinThe metabolism of Tamsulosin can be decreased when combined with Lovastatin.Approved, Investigational
TapentadolThe metabolism of Tapentadol can be decreased when combined with Lovastatin.Approved
TasosartanThe metabolism of Tasosartan can be decreased when combined with Lovastatin.Approved
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be decreased when combined with Lovastatin.Experimental
Taurocholic AcidThe serum concentration of Taurocholic Acid can be increased when it is combined with Lovastatin.Experimental
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Lovastatin.Approved
TelaprevirThe serum concentration of Lovastatin can be increased when it is combined with Telaprevir.Approved
TelithromycinThe serum concentration of Lovastatin can be increased when it is combined with Telithromycin.Approved
TemazepamThe metabolism of Temazepam can be decreased when combined with Lovastatin.Approved
TemocaprilThe serum concentration of Lovastatin can be increased when it is combined with Temocapril.Experimental, Investigational
TemsirolimusThe metabolism of Temsirolimus can be decreased when combined with Lovastatin.Approved
TeniposideThe metabolism of Teniposide can be decreased when combined with Lovastatin.Approved
TenoxicamThe metabolism of Tenoxicam can be decreased when combined with Lovastatin.Approved
TerbinafineThe metabolism of Terbinafine can be decreased when combined with Lovastatin.Approved, Investigational, Vet Approved
TerfenadineThe metabolism of Terfenadine can be decreased when combined with Lovastatin.Withdrawn
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Lovastatin.Investigational
TestosteroneThe metabolism of Testosterone can be decreased when combined with Lovastatin.Approved, Investigational
TetracyclineThe metabolism of Tetracycline can be decreased when combined with Lovastatin.Approved, Vet Approved
ThalidomideThe metabolism of Thalidomide can be decreased when combined with Lovastatin.Approved, Investigational, Withdrawn
TheophyllineThe metabolism of Theophylline can be decreased when combined with Lovastatin.Approved
ThiamylalThe metabolism of Thiamylal can be decreased when combined with Lovastatin.Approved, Vet Approved
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Lovastatin.Approved
ThiorphanThe serum concentration of Lovastatin can be increased when it is combined with Thiorphan.Experimental
ThiotepaThe metabolism of Thiotepa can be decreased when combined with Lovastatin.Approved
TiagabineThe metabolism of Tiagabine can be decreased when combined with Lovastatin.Approved
TicagrelorThe serum concentration of Lovastatin can be increased when it is combined with Ticagrelor.Approved
TiclopidineThe metabolism of Lovastatin can be decreased when combined with Ticlopidine.Approved
TimololThe serum concentration of Timolol can be increased when it is combined with Lovastatin.Approved
TinidazoleThe metabolism of Tinidazole can be decreased when combined with Lovastatin.Approved, Investigational
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Lovastatin.Approved
TipranavirThe serum concentration of Lovastatin can be increased when it is combined with Tipranavir.Approved, Investigational
TocilizumabThe serum concentration of Lovastatin can be decreased when it is combined with Tocilizumab.Approved
TofacitinibThe metabolism of Tofacitinib can be decreased when combined with Lovastatin.Approved, Investigational
TolbutamideThe metabolism of Tolbutamide can be decreased when combined with Lovastatin.Approved
TolterodineThe metabolism of Tolterodine can be decreased when combined with Lovastatin.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Lovastatin.Approved
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Lovastatin.Approved, Investigational
TorasemideThe metabolism of Torasemide can be decreased when combined with Lovastatin.Approved
ToremifeneThe metabolism of Toremifene can be decreased when combined with Lovastatin.Approved, Investigational
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Lovastatin.Approved, Investigational
TramadolThe metabolism of Tramadol can be decreased when combined with Lovastatin.Approved, Investigational
TrandolaprilThe serum concentration of Lovastatin can be increased when it is combined with Trandolapril.Approved
Trastuzumab emtansineThe metabolism of Trastuzumab emtansine can be decreased when combined with Lovastatin.Approved
TrazodoneThe metabolism of Trazodone can be decreased when combined with Lovastatin.Approved, Investigational
TreprostinilThe metabolism of Treprostinil can be decreased when combined with Lovastatin.Approved, Investigational
TretinoinThe metabolism of Tretinoin can be decreased when combined with Lovastatin.Approved, Investigational, Nutraceutical
TriamcinoloneThe metabolism of Triamcinolone can be decreased when combined with Lovastatin.Approved, Vet Approved
TriazolamThe metabolism of Triazolam can be decreased when combined with Lovastatin.Approved
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Lovastatin.Approved
TrimethoprimThe metabolism of Trimethoprim can be decreased when combined with Lovastatin.Approved, Vet Approved
TrimipramineThe metabolism of Trimipramine can be decreased when combined with Lovastatin.Approved
TroglitazoneThe metabolism of Troglitazone can be decreased when combined with Lovastatin.Withdrawn
TroleandomycinThe metabolism of Troleandomycin can be decreased when combined with Lovastatin.Approved
UbenimexThe serum concentration of Lovastatin can be increased when it is combined with Ubenimex.Experimental
UdenafilThe metabolism of Udenafil can be decreased when combined with Lovastatin.Approved, Investigational
UlinastatinThe serum concentration of Lovastatin can be increased when it is combined with Ulinastatin.Investigational
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Lovastatin.Approved
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Lovastatin.Approved
ValdecoxibThe metabolism of Valdecoxib can be decreased when combined with Lovastatin.Investigational, Withdrawn
Valproic AcidThe metabolism of Valproic Acid can be decreased when combined with Lovastatin.Approved, Investigational
ValsartanThe metabolism of Valsartan can be decreased when combined with Lovastatin.Approved, Investigational
VandetanibThe metabolism of Vandetanib can be decreased when combined with Lovastatin.Approved
VanoxerineThe metabolism of Vanoxerine can be decreased when combined with Lovastatin.Investigational
VardenafilThe metabolism of Vardenafil can be decreased when combined with Lovastatin.Approved
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Lovastatin.Approved
VemurafenibThe metabolism of Vemurafenib can be decreased when combined with Lovastatin.Approved
VenetoclaxThe metabolism of Venetoclax can be decreased when combined with Lovastatin.Approved
VenlafaxineThe metabolism of Venlafaxine can be decreased when combined with Lovastatin.Approved
VerapamilThe serum concentration of Lovastatin can be increased when it is combined with Verapamil.Approved
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Lovastatin.Investigational
VilanterolThe metabolism of Vilanterol can be decreased when combined with Lovastatin.Approved
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Lovastatin.Approved
VildagliptinThe serum concentration of Lovastatin can be increased when it is combined with Vildagliptin.Approved, Investigational
VinblastineThe metabolism of Vinblastine can be decreased when combined with Lovastatin.Approved
VincristineThe serum concentration of Vincristine can be increased when it is combined with Lovastatin.Approved, Investigational
VincristineThe metabolism of Vincristine can be decreased when combined with Lovastatin.Approved, Investigational
VindesineThe serum concentration of Vindesine can be increased when it is combined with Lovastatin.Approved
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Lovastatin.Approved, Investigational
VismodegibThe metabolism of Vismodegib can be decreased when combined with Lovastatin.Approved
VoriconazoleThe serum concentration of Lovastatin can be increased when it is combined with Voriconazole.Approved, Investigational
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Lovastatin.Approved
WarfarinThe metabolism of Warfarin can be decreased when combined with Lovastatin.Approved
XimelagatranThe serum concentration of Lovastatin can be increased when it is combined with Ximelagatran.Approved, Investigational, Withdrawn
Ym150The serum concentration of Lovastatin can be increased when it is combined with Ym150.Investigational
YohimbineThe metabolism of Yohimbine can be decreased when combined with Lovastatin.Approved, Vet Approved
ZafirlukastThe metabolism of Zafirlukast can be decreased when combined with Lovastatin.Approved, Investigational
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Lovastatin.Approved
ZaleplonThe metabolism of Zaleplon can be decreased when combined with Lovastatin.Approved, Illicit, Investigational
ZaltoprofenThe metabolism of Zaltoprofen can be decreased when combined with Lovastatin.Approved
ZidovudineThe metabolism of Zidovudine can be decreased when combined with Lovastatin.Approved
ZileutonThe metabolism of Zileuton can be decreased when combined with Lovastatin.Approved, Investigational, Withdrawn
ZiprasidoneThe metabolism of Ziprasidone can be decreased when combined with Lovastatin.Approved
ZolpidemThe metabolism of Zolpidem can be decreased when combined with Lovastatin.Approved
ZomepiracThe metabolism of Zomepirac can be decreased when combined with Lovastatin.Withdrawn
ZonisamideThe metabolism of Zonisamide can be decreased when combined with Lovastatin.Approved, Investigational
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Lovastatin.Approved
ZuclopenthixolThe serum concentration of Zuclopenthixol can be increased when it is combined with Lovastatin.Approved, Investigational
Food Interactions
  • Avoid alcohol.
  • Avoid drastic changes in dietary habit.
  • Avoid taking with grapefruit juice.
  • Take with food, 50% increase in bioavailability when taken with food.
References
Synthesis Reference

Donald F. Gerson, Xinfa Xiao, “Process for the production of lovastatin using Coniothyrium fuckelii.” U.S. Patent US5409820, issued January, 1984.

US5409820
General References
  1. Bobek P, Ozdin L, Galbavy S: Dose- and time-dependent hypocholesterolemic effect of oyster mushroom (Pleurotus ostreatus) in rats. Nutrition. 1998 Mar;14(3):282-6. [PubMed:9583372 ]
External Links
ATC CodesC10BA01C10AA02
AHFS Codes
  • 24:06.08
PDB EntriesNot Available
FDA labelDownload (126 KB)
MSDSDownload (99.6 KB)
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9452
Blood Brain Barrier+0.9287
Caco-2 permeable-0.5484
P-glycoprotein substrateSubstrate0.7861
P-glycoprotein inhibitor IInhibitor0.7046
P-glycoprotein inhibitor IIInhibitor0.8388
Renal organic cation transporterNon-inhibitor0.8299
CYP450 2C9 substrateNon-substrate0.8333
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateSubstrate0.6868
CYP450 1A2 substrateNon-inhibitor0.9045
CYP450 2C9 inhibitorNon-inhibitor0.9291
CYP450 2D6 inhibitorNon-inhibitor0.923
CYP450 2C19 inhibitorNon-inhibitor0.9026
CYP450 3A4 inhibitorInhibitor0.796
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8682
Ames testNon AMES toxic0.8475
CarcinogenicityNon-carcinogens0.9519
BiodegradationNot ready biodegradable0.8819
Rat acute toxicity2.0554 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.7272
hERG inhibition (predictor II)Non-inhibitor0.7484
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Andrx labs llc
  • Actavis elizabeth llc
  • Apotex inc
  • Carlsbad technology inc
  • Lupin ltd
  • Mutual pharmaceutical co inc
  • Mylan pharmaceuticals inc
  • Sandoz inc
  • Teva pharmaceuticals usa inc
  • Merck research laboratories div merck co inc
Packagers
Dosage forms
FormRouteStrength
Tablet, extended releaseOral
Tablet, extended release; tablet, multilayer, extended releaseOral
Tablet, extended releaseOral20 mg/1
Tablet, extended releaseOral40 mg/1
Tablet, extended releaseOral60 mg/1
TabletOral20 mg
TabletOral40 mg
TabletOral10 mg/1
TabletOral20 mg/1
TabletOral40 mg/1
Prices
Unit descriptionCostUnit
Altoprev 60 mg 24 Hour tablet7.99USD tablet
Altoprev 60 mg tablet7.74USD tablet
Altoprev 20 mg 24 Hour tablet6.88USD tablet
Altoprev 20 mg tablet6.61USD tablet
Mevacor 40 mg tablet4.57USD tablet
Altoprev 40 mg tablet4.41USD tablet
Lovastatin 40 mg tablet4.36USD tablet
Altoprev 10 mg 24 Hour tablet3.07USD tablet
Mevacor 20 mg tablet2.53USD tablet
Lovastatin 20 mg tablet2.42USD tablet
Altocor 20 mg 24 Hour tablet2.36USD tablet
Apo-Lovastatin 40 mg Tablet2.11USD tablet
Co Lovastatin 40 mg Tablet2.11USD tablet
Mylan-Lovastatin 40 mg Tablet2.11USD tablet
Novo-Lovastatin 40 mg Tablet2.11USD tablet
Pms-Lovastatin 40 mg Tablet2.11USD tablet
Ran-Lovastatin 40 mg Tablet2.11USD tablet
Ratio-Lovastatin 40 mg Tablet2.11USD tablet
Sandoz Lovastatin 40 mg Tablet2.11USD tablet
Mevacor 10 mg tablet1.65USD tablet
Lovastatin 10 mg tablet1.37USD tablet
Apo-Lovastatin 20 mg Tablet1.14USD tablet
Co Lovastatin 20 mg Tablet1.14USD tablet
Mylan-Lovastatin 20 mg Tablet1.14USD tablet
Novo-Lovastatin 20 mg Tablet1.14USD tablet
Pms-Lovastatin 20 mg Tablet1.14USD tablet
Ran-Lovastatin 20 mg Tablet1.14USD tablet
Ratio-Lovastatin 20 mg Tablet1.14USD tablet
Sandoz Lovastatin 20 mg Tablet1.14USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US5916595 No1997-12-122017-12-12Us
US6080428 No1997-05-272017-05-27Us
US6080778 No1998-03-232018-03-23Us
US6469035 No1998-03-152018-03-15Us
US6485748 No1997-12-122017-12-12Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point174.5 °CNot Available
water solubility0.0004 mg/mLNot Available
logP4.26HANSCH,C ET AL. (1995)
Predicted Properties
PropertyValueSource
Water Solubility0.0243 mg/mLALOGPS
logP4.11ALOGPS
logP3.9ChemAxon
logS-4.2ALOGPS
pKa (Strongest Acidic)14.91ChemAxon
pKa (Strongest Basic)-2.8ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area72.83 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity113.18 m3·mol-1ChemAxon
Polarizability46.11 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as delta valerolactones. These are cyclic organic compounds containing an oxan-2- one moiety.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassLactones
Sub ClassDelta valerolactones
Direct ParentDelta valerolactones
Alternative Parents
Substituents
  • Delta_valerolactone
  • Fatty acid ester
  • Delta valerolactone
  • Fatty acyl
  • Oxane
  • Dicarboxylic acid or derivatives
  • Saccharide
  • Secondary alcohol
  • Carboxylic acid ester
  • Oxacycle
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organooxygen compound
  • Carbonyl group
  • Alcohol
  • Aliphatic heteropolycyclic compound
Molecular FrameworkAliphatic heteropolycyclic compounds
External Descriptors

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Nadph binding
Specific Function:
Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.
Gene Name:
HMGCR
Uniprot ID:
P04035
Molecular Weight:
97475.155 Da
References
  1. Abe Y, Suzuki T, Ono C, Iwamoto K, Hosobuchi M, Yoshikawa H: Molecular cloning and characterization of an ML-236B (compactin) biosynthetic gene cluster in Penicillium citrinum. Mol Genet Genomics. 2002 Jul;267(5):636-46. Epub 2002 Jun 28. [PubMed:12172803 ]
  2. Miyazaki A, Koieyama T, Shimada Y, Kikuchi T, Nezu H, Ito K, Kasanuki N, Koga T: Effects of pravastatin sodium on mevalonate metabolism in common marmosets. J Biochem. 2002 Sep;132(3):395-400. [PubMed:12204108 ]
  3. Buxbaum JD, Geoghagen NS, Friedhoff LT: Cholesterol depletion with physiological concentrations of a statin decreases the formation of the Alzheimer amyloid Abeta peptide. J Alzheimers Dis. 2001 Apr;3(2):221-229. [PubMed:12214063 ]
  4. Baranova NA, Kreier VG, Egorov NS: [Concentration on Diapak C 16 capsules of lovastatin, mevinolinic acid and other inhibitors of biosynthesis of sterins produced by Penicillium citrinum 89]. Antibiot Khimioter. 2002;47(4):3-6. [PubMed:12369143 ]
  5. Farina HG, Bublik DR, Alonso DF, Gomez DE: Lovastatin alters cytoskeleton organization and inhibits experimental metastasis of mammary carcinoma cells. Clin Exp Metastasis. 2002;19(6):551-9. [PubMed:12405293 ]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  7. Podar K, Tai YT, Hideshima T, Vallet S, Richardson PG, Anderson KC: Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127. doi: 10.1517/14728210802676278 . [PubMed:19249983 ]
  8. Dimitroulakos J, Marhin WH, Tokunaga J, Irish J, Gullane P, Penn LZ, Kamel-Reid S: Microarray and biochemical analysis of lovastatin-induced apoptosis of squamous cell carcinomas. Neoplasia. 2002 Jul-Aug;4(4):337-46. [PubMed:12082550 ]
Kind
Protein
Organism
Human
Pharmacological action
no
Actions
other/unknown
General Function:
Metal ion binding
Specific Function:
Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.
Gene Name:
ITGAL
Uniprot ID:
P20701
Molecular Weight:
128768.495 Da
References
  1. Kallen J, Welzenbach K, Ramage P, Geyl D, Kriwacki R, Legge G, Cottens S, Weitz-Schmidt G, Hommel U: Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain. J Mol Biol. 1999 Sep 10;292(1):1-9. [PubMed:10493852 ]
Kind
Protein
Organism
Human
Pharmacological action
no
Actions
other
General Function:
Transcription factor binding
Specific Function:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor c...
Gene Name:
HDAC2
Uniprot ID:
Q92769
Molecular Weight:
55363.855 Da
References
  1. Lin YC, Lin JH, Chou CW, Chang YF, Yeh SH, Chen CC: Statins increase p21 through inhibition of histone deacetylase activity and release of promoter-associated HDAC1/2. Cancer Res. 2008 Apr 1;68(7):2375-83. doi: 10.1158/0008-5472.CAN-07-5807. [PubMed:18381445 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Neuvonen PJ, Niemi M, Backman JT: Drug interactions with lipid-lowering drugs: mechanisms and clinical relevance. Clin Pharmacol Ther. 2006 Dec;80(6):565-81. [PubMed:17178259 ]
  2. Cohen LH, van Leeuwen RE, van Thiel GC, van Pelt JF, Yap SH: Equally potent inhibitors of cholesterol synthesis in human hepatocytes have distinguishable effects on different cytochrome P450 enzymes. Biopharm Drug Dispos. 2000 Dec;21(9):353-64. [PubMed:11523064 ]
  3. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  4. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  5. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A5
Uniprot ID:
P20815
Molecular Weight:
57108.065 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A7
Uniprot ID:
P24462
Molecular Weight:
57525.03 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Protein homodimerization activity
Specific Function:
Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents.
Gene Name:
PON3
Uniprot ID:
Q15166
Molecular Weight:
39607.185 Da
References
  1. Draganov DI, Stetson PL, Watson CE, Billecke SS, La Du BN: Rabbit serum paraoxonase 3 (PON3) is a high density lipoprotein-associated lactonase and protects low density lipoprotein against oxidation. J Biol Chem. 2000 Oct 27;275(43):33435-42. [PubMed:10931838 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme...
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular Weight:
55824.275 Da
References
  1. Tornio A, Pasanen MK, Laitila J, Neuvonen PJ, Backman JT: Comparison of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) as inhibitors of cytochrome P450 2C8. Basic Clin Pharmacol Toxicol. 2005 Aug;97(2):104-8. [PubMed:15998357 ]
  2. Walsky RL, Gaman EA, Obach RS: Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol. 2005 Jan;45(1):68-78. [PubMed:15601807 ]
  3. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitorinducer
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Cohen LH, van Leeuwen RE, van Thiel GC, van Pelt JF, Yap SH: Equally potent inhibitors of cholesterol synthesis in human hepatocytes have distinguishable effects on different cytochrome P450 enzymes. Biopharm Drug Dispos. 2000 Dec;21(9):353-64. [PubMed:11523064 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Cohen LH, van Leeuwen RE, van Thiel GC, van Pelt JF, Yap SH: Equally potent inhibitors of cholesterol synthesis in human hepatocytes have distinguishable effects on different cytochrome P450 enzymes. Biopharm Drug Dispos. 2000 Dec;21(9):353-64. [PubMed:11523064 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid binding
Specific Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4-methylumbelliferone, 1-naph...
Gene Name:
UGT1A1
Uniprot ID:
P22309
Molecular Weight:
59590.91 Da
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Retinoic acid binding
Specific Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.
Gene Name:
UGT1A3
Uniprot ID:
P35503
Molecular Weight:
60337.835 Da
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Glucuronosyltransferase activity
Specific Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.Its unique specificity for 3,4-catechol estrogens and estriol suggests it may play an important role in regulating the level and activity of these potent and active estrogen metabolites. Is also active with androsterone, hyodeoxycholic acid and tetrachlorocatechol...
Gene Name:
UGT2B7
Uniprot ID:
P16662
Molecular Weight:
60694.12 Da
References
  1. Prueksaritanont T, Subramanian R, Fang X, Ma B, Qiu Y, Lin JH, Pearson PG, Baillie TA: Glucuronidation of statins in animals and humans: a novel mechanism of statin lactonization. Drug Metab Dispos. 2002 May;30(5):505-12. [PubMed:11950779 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Wang E, Casciano CN, Clement RP, Johnson WW: HMG-CoA reductase inhibitors (statins) characterized as direct inhibitors of P-glycoprotein. Pharm Res. 2001 Jun;18(6):800-6. [PubMed:11474784 ]
  2. Wang EJ, Casciano CN, Clement RP, Johnson WW: Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors. Biochem Biophys Res Commun. 2001 Nov 30;289(2):580-5. [PubMed:11716514 ]
  3. Kim RB, Wandel C, Leake B, Cvetkovic M, Fromm MF, Dempsey PJ, Roden MM, Belas F, Chaudhary AK, Roden DM, Wood AJ, Wilkinson GR: Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein. Pharm Res. 1999 Mar;16(3):408-14. [PubMed:10213372 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin.
Gene Name:
SLCO1A2
Uniprot ID:
P46721
Molecular Weight:
74144.105 Da
References
  1. Cvetkovic M, Leake B, Fromm MF, Wilkinson GR, Kim RB: OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab Dispos. 1999 Aug;27(8):866-71. [PubMed:10421612 ]
  2. Hsiang B, Zhu Y, Wang Z, Wu Y, Sasseville V, Yang WP, Kirchgessner TG: A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters. J Biol Chem. 1999 Dec 24;274(52):37161-8. [PubMed:10601278 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver.
Gene Name:
SLCO1B1
Uniprot ID:
Q9Y6L6
Molecular Weight:
76447.99 Da
References
  1. Hsiang B, Zhu Y, Wang Z, Wu Y, Sasseville V, Yang WP, Kirchgessner TG: A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters. J Biol Chem. 1999 Dec 24;274(52):37161-8. [PubMed:10601278 ]
  2. Sandhu P, Lee W, Xu X, Leake BF, Yamazaki M, Stone JA, Lin JH, Pearson PG, Kim RB: Hepatic uptake of the novel antifungal agent caspofungin. Drug Metab Dispos. 2005 May;33(5):676-82. Epub 2005 Feb 16. [PubMed:15716364 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Organic anion transmembrane transporter activity
Specific Function:
Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.
Gene Name:
ABCC2
Uniprot ID:
Q92887
Molecular Weight:
174205.64 Da
References
  1. Ellis LC, Hawksworth GM, Weaver RJ: ATP-dependent transport of statins by human and rat MRP2/Mrp2. Toxicol Appl Pharmacol. 2013 Jun 1;269(2):187-94. doi: 10.1016/j.taap.2013.03.019. Epub 2013 Apr 2. [PubMed:23562342 ]
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Drug created on June 13, 2005 07:24 / Updated on December 02, 2016 02:42