Identification

Name
Lovastatin
Accession Number
DB00227  (APRD00370)
Type
Small Molecule
Groups
Approved, Investigational
Description

Lovastatin is a cholesterol-lowering agent that belongs to the class of medications called statins. It was the second agent of this class discovered. It was discovered by Alfred Alberts and his team at Merck in 1978 after screening only 18 compounds over 2 weeks. The agent, also known as mevinolin, was isolated from the fungi Aspergillus terreus. Research on this compound was suddenly shut down in 1980 and the drug was not approved until 1987. Interesting, Akira Endo at Sankyo Co. (Japan) patented lovastatin isolated from Monascus ruber four months before Merck. Lovastatin was found to be 2 times more potent than its predecessor, mevastatin, the first discovered statin. Like mevastatin, lovastatin is structurally similar to hydroxymethylglutarate (HMG), a substituent of HMG-Coenzyme A (HMG-CoA), a substrate of the cholesterol biosynthesis pathway via the mevalonic acid pathway. Lovastatin is a competitive inhibitor of HMG-CoA reductase with a binding affinity 20,000 times greater than HMG-CoA. Lovastatin differs structurally from mevastatin by a single methyl group at the 6’ position. Lovastatin is a prodrug that is activated by in vivo hydrolysis of the lactone ring. It, along with mevastatin, has served as one of the lead compounds for the development of the synthetic compounds used today.

Structure
Thumb
Synonyms
  • (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(2R,4R)-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl (S)-2-methyl-butyrate
  • 2β,6α-dimethyl-8alpha-(2-methyl-1-oxobutoxy)-mevinic acid lactone
  • 6-alpha-methylcompactin
  • 6alpha-methylcompactin
  • 6α-methylcompactin
  • Lovastatina
  • Lovastatine
  • Lovastatinum
  • Mevinolin
External IDs
L-154803 / MK-803 / ML-530B
Product Images
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Act LovastatinTablet40 mgOralActavis Pharma Company2004-07-28Not applicableCanada
Act LovastatinTablet20 mgOralActavis Pharma Company2004-07-28Not applicableCanada
AltoprevTablet, extended release20 mg/1OralCovis Pharma2016-05-01Not applicableUs
AltoprevTablet, extended release20 mg/1OralShionogi2002-06-262017-12-31Us
AltoprevTablet, extended release60 mg/1OralCovis Pharma2016-05-01Not applicableUs
AltoprevTablet, extended release60 mg/1OralShionogi2002-06-262016-12-31Us
AltoprevTablet, extended release40 mg/1OralCovis Pharma2016-05-01Not applicableUs
AltoprevTablet, extended release40 mg/1OralShionogi2002-06-262018-02-28Us
LovastatinTablet20 mgOralCobalt LaboratoriesNot applicableNot applicableCanada
LovastatinTablet40 mgOralSanis Health Inc2010-07-26Not applicableCanada
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-lovastatin - Tab 20mgTablet20 mgOralApotex Corporation1997-03-27Not applicableCanada
Apo-lovastatin - Tab 40mgTablet40 mgOralApotex Corporation1997-03-27Not applicableCanada
Ava-lovastatinTablet40 mgOralAvanstra Inc2011-08-182014-08-21Canada
Ava-lovastatinTablet20 mgOralAvanstra Inc2011-08-182014-08-21Canada
Dom-lovastatinTablet40 mgOralDominion Pharmacal2003-02-25Not applicableCanada
Dom-lovastatinTablet20 mgOralDominion Pharmacal2003-02-25Not applicableCanada
LovastatinTablet40 mg/1OralDirectrx2014-01-012018-03-15Us
LovastatinTablet40 mg/1OralRemedy Repack2017-08-21Not applicableUs
LovastatinTablet40 mg/1OralA S Medication Solutions2007-11-01Not applicableUs
LovastatinTablet40 mg/1OralPhysicians Total Care, Inc.2003-04-14Not applicableUs
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
AdvicorLovastatin (20 mg/1) + Niacin (500 mg/1)Tablet, extended releaseOralPhysicians Total Care, Inc.2003-06-032017-03-11Us
AdvicorLovastatin (40 mg/1) + Niacin (1000 mg/1)Tablet, extended releaseOralAbbvie2001-12-172018-01-31Us
AdvicorLovastatin (20 mg/1) + Niacin (750 mg/1)Tablet, extended releaseOralAbbvie2001-12-172017-04-30Us
AdvicorLovastatin (20 mg) + Niacin (500 mg)Tablet, extended release; Tablet, multilayer, extended releaseOralSepracor Pharmaceuticals Inc2005-11-092012-08-02Canada
AdvicorLovastatin (20 mg/1) + Niacin (1000 mg/1)Tablet, extended releaseOralAbbvie2001-12-172017-11-30Us
AdvicorLovastatin (40 mg) + Niacin (1000 mg)Tablet, extended release; Tablet, multilayer, extended releaseOralSepracor Pharmaceuticals Inc2007-05-152010-07-26Canada
AdvicorLovastatin (40 mg/1) + Niacin (1000 mg/1)Tablet, extended releaseOralPhysicians Total Care, Inc.2006-08-08Not applicableUs
AdvicorLovastatin (20 mg/1) + Niacin (500 mg/1)Tablet, extended releaseOralAbbvie2001-12-172018-03-31Us
AdvicorLovastatin (20 mg) + Niacin (1000 mg)Tablet, extended release; Tablet, multilayer, extended releaseOralSepracor Pharmaceuticals Inc2005-11-092012-08-02Canada
International/Other Brands
Altocor / Mevacor
Categories
UNII
9LHU78OQFD
CAS number
75330-75-5
Weight
Average: 404.5396
Monoisotopic: 404.256274262
Chemical Formula
C24H36O5
InChI Key
PCZOHLXUXFIOCF-BXMDZJJMSA-N
InChI
InChI=1S/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18-21,23,25H,5,8-9,11-13H2,1-4H3/t14-,15-,16-,18+,19+,20-,21-,23-/m0/s1
IUPAC Name
(1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate
SMILES
[H][C@]12[C@H](C[C@@H](C)C=C1C=C[C@H](C)[C@@H]2CC[C@@H]1C[C@@H](O)CC(=O)O1)OC(=O)[C@@H](C)CC

Pharmacology

Indication

For management as an adjunct to diet to reduce elevated total-C, LDL-C, apo B, and TG levels in patients with primary hypercholesterolemia and mixed dyslipidemia. For primary prevention of coronary heart disease and to slow progression of coronary atherosclerosis in patients with coronary heart disease.

Associated Conditions
Pharmacodynamics

The primary cause of cardiovascular disease is atherosclerotic plaque formation. Sustained elevations of cholesterol in the blood increase the risk of cardiovascular disease. Lovastatin lowers hepatic cholesterol synthesis by competitively inhibiting HMG-CoA reductase, the enzyme that catalyzes the rate-limiting step in the cholesterol biosynthesis pathway via the mevalonic acid pathway. Decreased hepatic cholesterol levels causes increased uptake of low density lipoprotein (LDL) cholesterol and reduces cholesterol levels in the circulation. At therapeutic doses, lovastatin decreases serum LDL cholesterol by 29-32%, increases high density lipoprotein (HDL) cholesterol by 4.6-7.3%, and decrease triglyceride levels by 2-12%. HDL cholesterol is thought to confer protective effects against CV disease, whereas high LDL and triglyceride levels are associated with higher risk of disease.

Mechanism of action

Lovastatin is structurally similar to the HMG, a substituent of the endogenous substrate of HMG-CoA reductase. Lovastatin is a prodrug that is activated in vivo via hydrolysis of the lactone ring to form the β-hydroxyacid. The hydrolyzed lactone ring mimics the tetrahedral intermediate produced by the reductase allowing the agent to bind to HMG-CoA reductase with 20,000 times greater affinity than its natural substrate. The bicyclic portion of lovastatin binds to the coenzyme A portion of the active site.

TargetActionsOrganism
A3-hydroxy-3-methylglutaryl-coenzyme A reductase
inhibitor
Human
NIntegrin alpha-L
other/unknown
Human
NHistone deacetylase 2
other
Human
Absorption

Studies suggest that <5% of the oral dose reaches the general circulation as active inhibitors. Time to peak serum concentration is 2-4 hours. Lovastatin undergoes extensive first-pass metabolism so the availability of the drug in the system is low and variable.

Volume of distribution

Lovastatin is able to cross the blood-brain-barrier and placenta.

Protein binding

Lovastatin and its β-hydroxyacid metabolites are highly protein bound (>95%).

Metabolism

Lovastatin is hepatically metabolized in which the major active metabolites are the β-hydroxyacid of lovastatin, the 6’-hydroxy derivative, and two additional metabolites.

Route of elimination

Lovastatin undergoes extensive first-pass extraction in the liver, its primary site of action, with subsequent excretion of drug equivalents in the bile. 83% of the orally administered dose is excreted in bile and 10% is excreted in urine.

Half life

5.3 hours

Clearance
Not Available
Toxicity

LD50>1000 mg/kg (orally in mice)

Affected organisms
  • Humans and other mammals
Pathways
PathwayCategory
Lovastatin Action PathwayDrug action
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
(1S,6R)-3-{[3-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL]CARBONYL}-6-(2,4,5-TRIFLUOROPHENYL)CYCLOHEX-3-EN-1-AMINEThe serum concentration of Lovastatin can be increased when it is combined with (1S,6R)-3-{[3-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL]CARBONYL}-6-(2,4,5-TRIFLUOROPHENYL)CYCLOHEX-3-EN-1-AMINE.Experimental
1,10-PhenanthrolineThe serum concentration of Lovastatin can be increased when it is combined with 1,10-Phenanthroline.Experimental
3,4-DichloroisocoumarinThe serum concentration of Lovastatin can be increased when it is combined with 3,4-Dichloroisocoumarin.Experimental
4-(2-Aminoethyl)Benzenesulfonyl FluorideThe serum concentration of Lovastatin can be increased when it is combined with 4-(2-Aminoethyl)Benzenesulfonyl Fluoride.Experimental
6-Deoxyerythronolide BThe risk or severity of rhabdomyolysis can be increased when 6-Deoxyerythronolide B is combined with Lovastatin.Experimental
AbemaciclibThe metabolism of Abemaciclib can be decreased when combined with Lovastatin.Approved, Investigational
AbirateroneThe metabolism of Abiraterone can be decreased when combined with Lovastatin.Approved
AceclofenacThe metabolism of Aceclofenac can be decreased when combined with Lovastatin.Approved, Investigational
AcenocoumarolThe metabolism of Acenocoumarol can be decreased when combined with Lovastatin.Approved, Investigational
AcetaminophenThe serum concentration of Lovastatin can be increased when it is combined with Acetaminophen.Approved
AcetazolamideThe serum concentration of Lovastatin can be increased when it is combined with Acetazolamide.Approved, Vet Approved
Acetyl sulfisoxazoleThe serum concentration of Lovastatin can be increased when it is combined with Acetyl sulfisoxazole.Approved, Vet Approved
Acetylsalicylic acidThe metabolism of Acetylsalicylic acid can be decreased when combined with Lovastatin.Approved, Vet Approved
AcipimoxAcipimox may increase the myopathic rhabdomyolysis activities of Lovastatin.Approved, Investigational
AdinazolamThe metabolism of Adinazolam can be decreased when combined with Lovastatin.Approved
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Lovastatin.Approved
AgmatineThe metabolism of Agmatine can be decreased when combined with Lovastatin.Experimental, Investigational
AlbendazoleThe metabolism of Albendazole can be decreased when combined with Lovastatin.Approved, Vet Approved
AlclometasoneThe metabolism of Alclometasone can be decreased when combined with Lovastatin.Approved
AldesleukinThe serum concentration of Lovastatin can be increased when it is combined with Aldesleukin.Approved
AlfentanilThe metabolism of Alfentanil can be decreased when combined with Lovastatin.Approved, Illicit
AlfuzosinThe metabolism of Alfuzosin can be decreased when combined with Lovastatin.Approved, Investigational
AliskirenThe metabolism of Aliskiren can be decreased when combined with Lovastatin.Approved, Investigational
AllylestrenolThe metabolism of Allylestrenol can be decreased when combined with Lovastatin.Approved
AlmasilateThe serum concentration of Lovastatin can be decreased when it is combined with Almasilate.Approved, Experimental
AlmotriptanThe metabolism of Almotriptan can be decreased when combined with Lovastatin.Approved, Investigational
AlogliptinThe serum concentration of Lovastatin can be increased when it is combined with Alogliptin.Approved
AloglutamolThe serum concentration of Lovastatin can be decreased when it is combined with Aloglutamol.Approved
AlosetronThe metabolism of Alosetron can be decreased when combined with Lovastatin.Approved, Withdrawn
Alpha-1-proteinase inhibitorThe serum concentration of Lovastatin can be increased when it is combined with Alpha-1-proteinase inhibitor.Approved
alpha-Tocopherol acetateThe metabolism of alpha-Tocopherol acetate can be decreased when combined with Lovastatin.Approved
AlprazolamThe serum concentration of Lovastatin can be increased when it is combined with Alprazolam.Approved, Illicit, Investigational
AluminiumThe serum concentration of Lovastatin can be decreased when it is combined with Aluminium.Approved, Investigational
Aluminium acetoacetateThe serum concentration of Lovastatin can be decreased when it is combined with Aluminium acetoacetate.Experimental
Aluminium glycinateThe serum concentration of Lovastatin can be decreased when it is combined with Aluminium glycinate.Experimental
AmbrisentanThe metabolism of Ambrisentan can be decreased when combined with Lovastatin.Approved, Investigational
AmbroxolThe serum concentration of Lovastatin can be increased when it is combined with Ambroxol.Approved, Investigational
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Lovastatin.Approved, Withdrawn
AminophyllineThe metabolism of Aminophylline can be decreased when combined with Lovastatin.Approved
AmitriptylineThe metabolism of Amitriptyline can be decreased when combined with Lovastatin.Approved
AmlodipineThe serum concentration of Lovastatin can be increased when it is combined with Amlodipine.Approved
AmodiaquineThe serum concentration of Amodiaquine can be increased when it is combined with Lovastatin.Approved, Investigational
Amphotericin BThe risk or severity of rhabdomyolysis can be increased when Amphotericin B is combined with Lovastatin.Approved, Investigational
AmprenavirThe serum concentration of Lovastatin can be increased when it is combined with Amprenavir.Approved, Investigational
AntipyrineThe serum concentration of Lovastatin can be increased when it is combined with Antipyrine.Approved, Investigational
Antithrombin III humanThe serum concentration of Lovastatin can be increased when it is combined with Antithrombin III human.Approved
ApalutamideThe serum concentration of Lovastatin can be decreased when it is combined with Apalutamide.Approved, Investigational
ApixabanThe serum concentration of Lovastatin can be increased when it is combined with Apixaban.Approved
ApremilastThe metabolism of Apremilast can be decreased when combined with Lovastatin.Approved, Investigational
AprepitantThe serum concentration of Lovastatin can be increased when it is combined with Aprepitant.Approved, Investigational
AprotininThe serum concentration of Lovastatin can be increased when it is combined with Aprotinin.Approved, Investigational, Withdrawn
Arachidonic AcidThe metabolism of Arachidonic Acid can be decreased when combined with Lovastatin.Experimental
AranidipineThe metabolism of Aranidipine can be decreased when combined with Lovastatin.Approved, Investigational
ArformoterolThe metabolism of Arformoterol can be decreased when combined with Lovastatin.Approved, Investigational
ArgatrobanThe serum concentration of Lovastatin can be increased when it is combined with Argatroban.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Lovastatin.Approved, Investigational
Arsenic trioxideThe serum concentration of Lovastatin can be increased when it is combined with Arsenic trioxide.Approved, Investigational
ArtemetherThe metabolism of Artemether can be decreased when combined with Lovastatin.Approved
AsenapineThe metabolism of Asenapine can be decreased when combined with Lovastatin.Approved
AstemizoleThe serum concentration of Lovastatin can be increased when it is combined with Astemizole.Approved, Withdrawn
AsunaprevirThe serum concentration of Lovastatin can be increased when it is combined with Asunaprevir.Approved, Investigational, Withdrawn
AtazanavirThe serum concentration of Lovastatin can be increased when it is combined with Atazanavir.Approved, Investigational
AtomoxetineThe serum concentration of Lovastatin can be increased when it is combined with Atomoxetine.Approved
AtorvastatinThe risk or severity of adverse effects can be increased when Lovastatin is combined with Atorvastatin.Approved
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Lovastatin.Approved
AvatrombopagThe metabolism of Avatrombopag can be decreased when combined with Lovastatin.Approved, Investigational
AVE9633The risk or severity of rhabdomyolysis can be increased when AVE9633 is combined with Lovastatin.Investigational
AxitinibThe metabolism of Axitinib can be decreased when combined with Lovastatin.Approved, Investigational
AzelastineThe serum concentration of Lovastatin can be increased when it is combined with Azelastine.Approved
AzelnidipineThe metabolism of Azelnidipine can be decreased when combined with Lovastatin.Approved, Investigational
AzithromycinThe serum concentration of Lovastatin can be increased when it is combined with Azithromycin.Approved
BanoxantroneThe metabolism of Banoxantrone can be decreased when combined with Lovastatin.Investigational
BaricitinibThe metabolism of Baricitinib can be decreased when combined with Lovastatin.Approved, Investigational
BarnidipineThe metabolism of Barnidipine can be decreased when combined with Lovastatin.Approved
BatimastatThe serum concentration of Lovastatin can be increased when it is combined with Batimastat.Experimental
Beclomethasone dipropionateThe metabolism of Beclomethasone dipropionate can be decreased when combined with Lovastatin.Approved, Investigational
BedaquilineThe metabolism of Bedaquiline can be decreased when combined with Lovastatin.Approved
BenazeprilThe serum concentration of Lovastatin can be increased when it is combined with Benazepril.Approved, Investigational
BencyclaneThe metabolism of Bencyclane can be decreased when combined with Lovastatin.Experimental
BenidipineThe metabolism of Benidipine can be decreased when combined with Lovastatin.Approved, Investigational
BenzamidineThe serum concentration of Lovastatin can be increased when it is combined with Benzamidine.Experimental
BenzphetamineThe metabolism of Benzphetamine can be decreased when combined with Lovastatin.Approved, Illicit
Benzyl alcoholThe serum concentration of Lovastatin can be increased when it is combined with Benzyl alcohol.Approved
BepridilThe serum concentration of Lovastatin can be increased when it is combined with Bepridil.Approved, Withdrawn
BetamethasoneThe serum concentration of Lovastatin can be increased when it is combined with Betamethasone.Approved, Vet Approved
BexaroteneThe metabolism of Bexarotene can be decreased when combined with Lovastatin.Approved, Investigational
BezafibrateBezafibrate may increase the myopathic rhabdomyolysis activities of Lovastatin.Approved, Investigational
BicalutamideThe serum concentration of Lovastatin can be increased when it is combined with Bicalutamide.Approved
BictegravirThe metabolism of Bictegravir can be decreased when combined with Lovastatin.Approved, Investigational
BifonazoleThe serum concentration of Lovastatin can be increased when it is combined with Bifonazole.Approved, Investigational
BioallethrinThe metabolism of Bioallethrin can be decreased when combined with Lovastatin.Approved, Experimental
Bismuth subcitrate potassiumThe serum concentration of Lovastatin can be decreased when it is combined with Bismuth Subcitrate.Approved, Investigational
Bismuth subnitrateThe serum concentration of Lovastatin can be decreased when it is combined with Bismuth subnitrate.Approved
BisoprololThe metabolism of Bisoprolol can be decreased when combined with Lovastatin.Approved
BivalirudinThe serum concentration of Lovastatin can be increased when it is combined with Bivalirudin.Approved, Investigational
BlonanserinThe metabolism of Blonanserin can be decreased when combined with Lovastatin.Approved, Investigational
BoceprevirThe serum concentration of Lovastatin can be increased when it is combined with Boceprevir.Approved, Withdrawn
BortezomibThe serum concentration of Lovastatin can be increased when it is combined with Bortezomib.Approved, Investigational
BosentanThe metabolism of Lovastatin can be increased when combined with Bosentan.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Lovastatin.Approved
Brefeldin AThe risk or severity of rhabdomyolysis can be increased when Brefeldin A is combined with Lovastatin.Experimental
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Lovastatin.Approved, Investigational
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Lovastatin.Approved, Investigational
BrigatinibThe serum concentration of Lovastatin can be decreased when it is combined with Brigatinib.Approved, Investigational
BrinzolamideThe metabolism of Brinzolamide can be decreased when combined with Lovastatin.Approved
BrivaracetamThe metabolism of Brivaracetam can be decreased when combined with Lovastatin.Approved, Investigational
BromazepamThe metabolism of Bromazepam can be decreased when combined with Lovastatin.Approved, Illicit, Investigational
BromocriptineThe serum concentration of Lovastatin can be increased when it is combined with Bromocriptine.Approved, Investigational
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Lovastatin.Approved
Bryostatin 1The risk or severity of rhabdomyolysis can be increased when Bryostatin 1 is combined with Lovastatin.Investigational
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Lovastatin.Approved
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Lovastatin.Approved, Investigational
BuprenorphineThe serum concentration of Lovastatin can be increased when it is combined with Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BupropionThe metabolism of Bupropion can be decreased when combined with Lovastatin.Approved
BuspironeThe metabolism of Buspirone can be decreased when combined with Lovastatin.Approved, Investigational
BusulfanThe metabolism of Busulfan can be decreased when combined with Lovastatin.Approved, Investigational
CabazitaxelThe metabolism of Cabazitaxel can be decreased when combined with Lovastatin.Approved
CabergolineThe serum concentration of Lovastatin can be increased when it is combined with Cabergoline.Approved
CabozantinibThe metabolism of Cabozantinib can be decreased when combined with Lovastatin.Approved, Investigational
CaffeineThe serum concentration of Lovastatin can be increased when it is combined with Caffeine.Approved
CalcitriolThe metabolism of Calcitriol can be decreased when combined with Lovastatin.Approved, Nutraceutical
Calcium silicateThe serum concentration of Lovastatin can be decreased when it is combined with Calcium silicate.Experimental
CamostatThe serum concentration of Lovastatin can be increased when it is combined with Camostat.Experimental
CanagliflozinThe metabolism of Canagliflozin can be decreased when combined with Lovastatin.Approved
CandesartanThe metabolism of Candesartan can be decreased when combined with Lovastatin.Experimental
Candesartan cilexetilThe metabolism of Candesartan cilexetil can be decreased when combined with Lovastatin.Approved
CandicidinThe risk or severity of rhabdomyolysis can be increased when Candicidin is combined with Lovastatin.Withdrawn
CandoxatrilThe serum concentration of Lovastatin can be increased when it is combined with Candoxatril.Experimental
CandoxatrilatThe serum concentration of Lovastatin can be increased when it is combined with Candoxatrilat.Experimental
CannabidiolThe metabolism of Cannabidiol can be decreased when combined with Lovastatin.Approved, Investigational
CapsaicinThe serum concentration of Lovastatin can be increased when it is combined with Capsaicin.Approved
CaptoprilThe serum concentration of Lovastatin can be increased when it is combined with Captopril.Approved
CarbamazepineThe serum concentration of Lovastatin can be decreased when it is combined with Carbamazepine.Approved, Investigational
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Lovastatin.Approved
CarbomycinThe risk or severity of rhabdomyolysis can be increased when Carbomycin is combined with Lovastatin.Vet Approved
CarboxyamidotriazoleThe metabolism of Carboxyamidotriazole can be decreased when combined with Lovastatin.Investigational
CariprazineThe metabolism of Cariprazine can be decreased when combined with Lovastatin.Approved, Investigational
CaroverineThe metabolism of Caroverine can be decreased when combined with Lovastatin.Experimental
CarvedilolThe serum concentration of Lovastatin can be increased when it is combined with Carvedilol.Approved, Investigational
CaspofunginThe serum concentration of Lovastatin can be increased when it is combined with Caspofungin.Approved
CelecoxibThe metabolism of Celecoxib can be decreased when combined with Lovastatin.Approved, Investigational
CeliprololThe metabolism of Celiprolol can be decreased when combined with Lovastatin.Approved, Investigational
CephalexinThe metabolism of Cephalexin can be decreased when combined with Lovastatin.Approved, Investigational, Vet Approved
CeritinibThe serum concentration of Lovastatin can be increased when it is combined with Ceritinib.Approved
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Lovastatin.Approved, Withdrawn
CethromycinThe risk or severity of rhabdomyolysis can be increased when Cethromycin is combined with Lovastatin.Investigational
CevimelineThe metabolism of Cevimeline can be decreased when combined with Lovastatin.Approved
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be decreased when combined with Lovastatin.Approved
ChloramphenicolThe serum concentration of Lovastatin can be increased when it is combined with Chloramphenicol.Approved, Vet Approved
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Lovastatin.Approved, Illicit, Investigational
ChloroquineThe metabolism of Chloroquine can be decreased when combined with Lovastatin.Approved, Investigational, Vet Approved
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Lovastatin.Approved
ChlorpromazineThe metabolism of Chlorpromazine can be decreased when combined with Lovastatin.Approved, Investigational, Vet Approved
ChlorpropamideThe metabolism of Chlorpropamide can be decreased when combined with Lovastatin.Approved, Investigational
ChlorzoxazoneThe serum concentration of Lovastatin can be increased when it is combined with Chlorzoxazone.Approved
CholecalciferolThe metabolism of Cholecalciferol can be decreased when combined with Lovastatin.Approved, Nutraceutical
CholestyramineCholestyramine can cause a decrease in the absorption of Lovastatin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
ChymostatinThe serum concentration of Lovastatin can be increased when it is combined with Chymostatin.Experimental
CiclesonideThe metabolism of Ciclesonide can be decreased when combined with Lovastatin.Approved, Investigational
CilazaprilThe serum concentration of Lovastatin can be increased when it is combined with Cilazapril.Approved
CilnidipineThe metabolism of Cilnidipine can be decreased when combined with Lovastatin.Approved, Investigational
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Lovastatin.Approved, Investigational
Cimicifuga racemosaThe serum concentration of Lovastatin can be increased when it is combined with Cimicifuga racemosa.Approved, Experimental
CinacalcetThe metabolism of Cinacalcet can be decreased when combined with Lovastatin.Approved
CinnarizineThe metabolism of Cinnarizine can be decreased when combined with Lovastatin.Approved, Investigational
CiprofibrateThe risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Ciprofibrate is combined with Lovastatin.Approved, Investigational
CiprofloxacinThe serum concentration of Ciprofloxacin can be increased when it is combined with Lovastatin.Approved, Investigational
CisaprideThe serum concentration of Lovastatin can be increased when it is combined with Cisapride.Approved, Investigational, Withdrawn
CitalopramThe metabolism of Citalopram can be decreased when combined with Lovastatin.Approved
ClarithromycinThe serum concentration of Lovastatin can be increased when it is combined with Clarithromycin.Approved
ClevidipineThe metabolism of Clevidipine can be decreased when combined with Lovastatin.Approved, Investigational
ClindamycinThe metabolism of Clindamycin can be decreased when combined with Lovastatin.Approved, Vet Approved
ClobazamThe metabolism of Clobazam can be decreased when combined with Lovastatin.Approved, Illicit
ClofazimineThe serum concentration of Lovastatin can be increased when it is combined with Clofazimine.Approved, Investigational
ClofibrateThe metabolism of Clofibrate can be decreased when combined with Lovastatin.Approved, Investigational
clomethiazoleThe metabolism of clomethiazole can be decreased when combined with Lovastatin.Investigational
ClomifeneThe serum concentration of Lovastatin can be increased when it is combined with Clomifene.Approved, Investigational
ClomipramineThe metabolism of Clomipramine can be decreased when combined with Lovastatin.Approved, Investigational, Vet Approved
ClonazepamThe metabolism of Clonazepam can be decreased when combined with Lovastatin.Approved, Illicit
ClonidineThe metabolism of Clonidine can be decreased when combined with Lovastatin.Approved
ClopidogrelThe metabolism of Clopidogrel can be decreased when combined with Lovastatin.Approved
ClorazepateThe metabolism of Clorazepate can be decreased when combined with Lovastatin.Approved, Illicit
ClotiazepamThe serum concentration of Lovastatin can be increased when it is combined with Clotiazepam.Approved, Illicit
ClotrimazoleThe serum concentration of Lovastatin can be increased when it is combined with Clotrimazole.Approved, Vet Approved
ClozapineThe serum concentration of Lovastatin can be increased when it is combined with Clozapine.Approved
CobicistatThe serum concentration of Lovastatin can be increased when it is combined with Cobicistat.Approved
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Lovastatin.Approved, Investigational
CocaineThe serum concentration of Lovastatin can be increased when it is combined with Cocaine.Approved, Illicit
CodeineThe metabolism of Codeine can be decreased when combined with Lovastatin.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Lovastatin.Approved
ColesevelamColesevelam can cause a decrease in the absorption of Lovastatin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
ColestipolColestipol can cause a decrease in the absorption of Lovastatin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Coltuximab ravtansineThe risk or severity of rhabdomyolysis can be increased when Coltuximab ravtansine is combined with Lovastatin.Investigational
ConivaptanThe serum concentration of Conivaptan can be increased when it is combined with Lovastatin.Approved, Investigational
Conjugated estrogensThe metabolism of Conjugated estrogens can be decreased when combined with Lovastatin.Approved
CopanlisibThe metabolism of Copanlisib can be decreased when combined with Lovastatin.Approved, Investigational
Cortisone acetateThe serum concentration of Lovastatin can be increased when it is combined with Cortisone acetate.Approved, Investigational
CrizotinibThe serum concentration of Lovastatin can be increased when it is combined with Crizotinib.Approved
CyclandelateThe metabolism of Cyclandelate can be decreased when combined with Lovastatin.Approved
CyclobenzaprineThe metabolism of Cyclobenzaprine can be decreased when combined with Lovastatin.Approved
CyclophosphamideThe serum concentration of Lovastatin can be increased when it is combined with Cyclophosphamide.Approved, Investigational
CyclosporineThe serum concentration of Lovastatin can be increased when it is combined with Cyclosporine.Approved, Investigational, Vet Approved
Cyproterone acetateThe serum concentration of Lovastatin can be increased when it is combined with Cyproterone acetate.Approved, Investigational
CytarabineThe metabolism of Cytarabine can be decreased when combined with Lovastatin.Approved, Investigational
Dabigatran etexilateThe serum concentration of Lovastatin can be increased when it is combined with Dabigatran etexilate.Approved
DabrafenibThe serum concentration of Lovastatin can be decreased when it is combined with Dabrafenib.Approved, Investigational
DaclatasvirThe serum concentration of Lovastatin can be increased when it is combined with Daclatasvir.Approved, Investigational
DalfopristinThe serum concentration of Lovastatin can be increased when it is combined with Dalfopristin.Approved
DanazolThe risk or severity of myopathy and rhabdomyolysis can be increased when Danazol is combined with Lovastatin.Approved
DantroleneThe metabolism of Dantrolene can be decreased when combined with Lovastatin.Approved, Investigational
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Lovastatin.Approved
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Lovastatin.Investigational
DapsoneThe metabolism of Dapsone can be decreased when combined with Lovastatin.Approved, Investigational
DaptomycinThe risk or severity of adverse effects can be increased when Lovastatin is combined with Daptomycin.Approved, Investigational
DarexabanThe serum concentration of Lovastatin can be increased when it is combined with Darexaban.Investigational
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Lovastatin.Approved, Investigational
DarodipineThe metabolism of Darodipine can be decreased when combined with Lovastatin.Experimental
DarunavirThe serum concentration of Lovastatin can be increased when it is combined with Darunavir.Approved
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Lovastatin.Approved
DasatinibThe serum concentration of Lovastatin can be increased when it is combined with Dasatinib.Approved, Investigational
DaunorubicinThe serum concentration of Lovastatin can be increased when it is combined with Daunorubicin.Approved
DeferasiroxThe serum concentration of Lovastatin can be decreased when it is combined with Deferasirox.Approved, Investigational
DeflazacortThe metabolism of Deflazacort can be decreased when combined with Lovastatin.Approved, Investigational
DelamanidThe metabolism of Delamanid can be decreased when combined with Lovastatin.Approved, Investigational
DelanzomibThe serum concentration of Lovastatin can be increased when it is combined with Delanzomib.Investigational
DelaprilThe serum concentration of Lovastatin can be increased when it is combined with Delapril.Investigational
DelavirdineThe serum concentration of Lovastatin can be increased when it is combined with Delavirdine.Approved
DesipramineThe serum concentration of Lovastatin can be increased when it is combined with Desipramine.Approved, Investigational
DesvenlafaxineThe metabolism of Desvenlafaxine can be decreased when combined with Lovastatin.Approved, Investigational
DeutetrabenazineThe metabolism of Deutetrabenazine can be decreased when combined with Lovastatin.Approved, Investigational
DexamethasoneThe serum concentration of Dexamethasone can be increased when it is combined with Lovastatin.Approved, Investigational, Vet Approved
Dexchlorpheniramine maleateThe metabolism of Dexchlorpheniramine maleate can be decreased when combined with Lovastatin.Approved
DexlansoprazoleThe metabolism of Dexlansoprazole can be decreased when combined with Lovastatin.Approved, Investigational
DexniguldipineThe serum concentration of Lovastatin can be increased when it is combined with Dexniguldipine.Experimental
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Lovastatin.Approved
DextropropoxypheneThe serum concentration of Lovastatin can be increased when it is combined with Dextropropoxyphene.Approved, Illicit, Investigational, Withdrawn
DexverapamilThe serum concentration of Lovastatin can be increased when it is combined with Dexverapamil.Experimental
DiazepamThe serum concentration of Lovastatin can be increased when it is combined with Diazepam.Approved, Illicit, Investigational, Vet Approved
DiclofenacThe metabolism of Diclofenac can be decreased when combined with Lovastatin.Approved, Vet Approved
DicoumarolThe metabolism of Dicoumarol can be decreased when combined with Lovastatin.Approved
DienogestThe metabolism of Dienogest can be decreased when combined with Lovastatin.Approved
DiethylstilbestrolThe serum concentration of Lovastatin can be increased when it is combined with Diethylstilbestrol.Approved, Investigational
DigitoxinThe metabolism of Digitoxin can be decreased when combined with Lovastatin.Approved, Investigational
DigoxinThe metabolism of Digoxin can be decreased when combined with Lovastatin.Approved
Dihydro-alpha-ergocryptineThe metabolism of Dihydro-alpha-ergocryptine can be decreased when combined with Lovastatin.Approved
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Lovastatin.Approved, Illicit
DihydroergocornineThe risk or severity of adverse effects can be increased when Dihydroergocornine is combined with Lovastatin.Approved
DihydroergocristineThe risk or severity of adverse effects can be increased when Dihydroergocristine is combined with Lovastatin.Approved, Experimental
DihydroergocryptineThe risk or severity of adverse effects can be increased when Dihydroergocryptine is combined with Lovastatin.Experimental
DihydroergotamineThe serum concentration of Lovastatin can be increased when it is combined with Dihydroergotamine.Approved, Investigational
DiltiazemThe serum concentration of Lovastatin can be increased when it is combined with Diltiazem.Approved, Investigational
Dimethyl sulfoxideThe serum concentration of Lovastatin can be increased when it is combined with Dimethyl sulfoxide.Approved, Vet Approved
DirithromycinThe risk or severity of rhabdomyolysis can be increased when Dirithromycin is combined with Lovastatin.Approved, Investigational
DisopyramideThe metabolism of Disopyramide can be decreased when combined with Lovastatin.Approved
DisulfiramThe metabolism of Disulfiram can be decreased when combined with Lovastatin.Approved
DocetaxelThe serum concentration of Lovastatin can be increased when it is combined with Docetaxel.Approved, Investigational
DoconexentThe metabolism of Doconexent can be decreased when combined with Lovastatin.Approved, Investigational
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Lovastatin.Approved, Investigational
DolasetronThe metabolism of Dolasetron can be decreased when combined with Lovastatin.Approved, Investigational
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Lovastatin.Approved, Investigational, Vet Approved
DonepezilThe metabolism of Donepezil can be decreased when combined with Lovastatin.Approved
DopamineThe metabolism of Dopamine can be decreased when combined with Lovastatin.Approved
DoramectinThe risk or severity of rhabdomyolysis can be increased when Doramectin is combined with Lovastatin.Vet Approved
DorzolamideThe metabolism of Dorzolamide can be decreased when combined with Lovastatin.Approved
DotarizineThe metabolism of Dotarizine can be decreased when combined with Lovastatin.Investigational
DoxazosinThe serum concentration of Lovastatin can be increased when it is combined with Doxazosin.Approved
DoxepinThe metabolism of Doxepin can be decreased when combined with Lovastatin.Approved, Investigational
DoxorubicinThe serum concentration of Lovastatin can be increased when it is combined with Doxorubicin.Approved, Investigational
DoxycyclineThe serum concentration of Lovastatin can be increased when it is combined with Doxycycline.Approved, Investigational, Vet Approved
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Lovastatin.Approved, Illicit
DronedaroneThe serum concentration of Lovastatin can be increased when it is combined with Dronedarone.Approved
DutasterideThe metabolism of Dutasteride can be decreased when combined with Lovastatin.Approved, Investigational
EcabetThe serum concentration of Lovastatin can be increased when it is combined with Ecabet.Approved, Investigational
EconazoleThe serum concentration of Lovastatin can be increased when it is combined with Econazole.Approved
EdoxabanThe serum concentration of Lovastatin can be increased when it is combined with Edoxaban.Approved
EfavirenzThe serum concentration of Lovastatin can be decreased when it is combined with Efavirenz.Approved, Investigational
EfonidipineThe metabolism of Efonidipine can be decreased when combined with Lovastatin.Approved, Investigational
ElafinThe serum concentration of Lovastatin can be increased when it is combined with Elafin.Investigational
ElbasvirThe serum concentration of Lovastatin can be increased when it is combined with Elbasvir.Approved
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Lovastatin.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Lovastatin.Approved
ElvitegravirThe metabolism of Elvitegravir can be decreased when combined with Lovastatin.Approved
EmopamilThe serum concentration of Lovastatin can be increased when it is combined with Emopamil.Experimental
EnalaprilThe serum concentration of Lovastatin can be increased when it is combined with Enalapril.Approved, Vet Approved
EnalaprilatThe serum concentration of Lovastatin can be increased when it is combined with Enalaprilat.Approved
EnalkirenThe serum concentration of Lovastatin can be increased when it is combined with Enalkiren.Experimental
EnasidenibThe serum concentration of Lovastatin can be increased when it is combined with Enasidenib.Approved, Investigational
EnzalutamideThe serum concentration of Lovastatin can be decreased when it is combined with Enzalutamide.Approved
EperisoneThe metabolism of Eperisone can be decreased when combined with Lovastatin.Approved, Investigational
EpinastineThe metabolism of Epinastine can be decreased when combined with Lovastatin.Approved, Investigational
EpinephrineThe serum concentration of Lovastatin can be increased when it is combined with Epinephrine.Approved, Vet Approved
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Lovastatin.Approved
EpofolateThe risk or severity of rhabdomyolysis can be increased when Epofolate is combined with Lovastatin.Investigational
EpoprostenolThe metabolism of Epoprostenol can be decreased when combined with Lovastatin.Approved
Epothilone DThe risk or severity of rhabdomyolysis can be increased when Epothilone D is combined with Lovastatin.Experimental, Investigational
EprinomectinThe risk or severity of rhabdomyolysis can be increased when Eprinomectin is combined with Lovastatin.Vet Approved
ErgocalciferolThe metabolism of Ergocalciferol can be decreased when combined with Lovastatin.Approved, Nutraceutical
Ergoloid mesylateThe metabolism of Ergoloid mesylate can be decreased when combined with Lovastatin.Approved
ErgonovineThe serum concentration of Lovastatin can be increased when it is combined with Ergonovine.Approved
ErgotamineThe serum concentration of Lovastatin can be increased when it is combined with Ergotamine.Approved
ErlotinibThe risk or severity of adverse effects can be increased when Erlotinib is combined with Lovastatin.Approved, Investigational
ErythromycinThe serum concentration of Lovastatin can be increased when it is combined with Erythromycin.Approved, Investigational, Vet Approved
EscitalopramThe metabolism of Escitalopram can be decreased when combined with Lovastatin.Approved, Investigational
EsomeprazoleThe metabolism of Esomeprazole can be decreased when combined with Lovastatin.Approved, Investigational
EstazolamThe metabolism of Estazolam can be decreased when combined with Lovastatin.Approved, Illicit
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Lovastatin.Approved, Investigational, Vet Approved
Estradiol acetateThe metabolism of Estradiol acetate can be decreased when combined with Lovastatin.Approved, Investigational, Vet Approved
Estradiol benzoateThe metabolism of Estradiol benzoate can be decreased when combined with Lovastatin.Approved, Investigational, Vet Approved
Estradiol cypionateThe metabolism of Estradiol cypionate can be decreased when combined with Lovastatin.Approved, Investigational, Vet Approved
Estradiol dienanthateThe metabolism of Estradiol dienanthate can be decreased when combined with Lovastatin.Approved, Investigational, Vet Approved
Estradiol valerateThe metabolism of Estradiol valerate can be decreased when combined with Lovastatin.Approved, Investigational, Vet Approved
EstramustineThe metabolism of Estramustine can be decreased when combined with Lovastatin.Approved, Investigational
Estrogens, esterifiedThe metabolism of Estrogens, esterified can be decreased when combined with Lovastatin.Approved
EstroneThe metabolism of Estrone can be decreased when combined with Lovastatin.Approved
Estrone sulfateThe metabolism of Estrone sulfate can be decreased when combined with Lovastatin.Approved
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Lovastatin.Approved, Investigational
EthanolThe risk or severity of myopathy and rhabdomyolysis can be increased when Ethanol is combined with Lovastatin.Approved
Ethinyl EstradiolThe serum concentration of Lovastatin can be decreased when it is combined with Ethinyl Estradiol.Approved
EthosuximideThe metabolism of Ethosuximide can be decreased when combined with Lovastatin.Approved
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Lovastatin.Approved, Illicit
EtizolamThe metabolism of Etizolam can be decreased when combined with Lovastatin.Approved
EtodolacThe metabolism of Etodolac can be decreased when combined with Lovastatin.Approved, Investigational, Vet Approved
EtonogestrelThe metabolism of Etonogestrel can be decreased when combined with Lovastatin.Approved, Investigational
EtoposideThe serum concentration of Lovastatin can be increased when it is combined with Etoposide.Approved
EtoricoxibThe serum concentration of Lovastatin can be increased when it is combined with Etoricoxib.Approved, Investigational
EtravirineThe serum concentration of Lovastatin can be decreased when it is combined with Etravirine.Approved
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Lovastatin.Approved
ExemestaneThe metabolism of Exemestane can be decreased when combined with Lovastatin.Approved, Investigational
EzetimibeThe serum concentration of Lovastatin can be increased when it is combined with Ezetimibe.Approved
FaldaprevirThe serum concentration of Lovastatin can be increased when it is combined with Faldaprevir.Investigational
FamciclovirThe metabolism of Famciclovir can be decreased when combined with Lovastatin.Approved, Investigational
FelbamateThe metabolism of Felbamate can be decreased when combined with Lovastatin.Approved
FelodipineThe serum concentration of Lovastatin can be increased when it is combined with Felodipine.Approved, Investigational
FendilineThe metabolism of Fendiline can be decreased when combined with Lovastatin.Withdrawn
FenofibrateThe risk or severity of myopathy and rhabdomyolysis can be increased when Fenofibrate is combined with Lovastatin.Approved
Fenofibric acidThe risk or severity of myopathy and rhabdomyolysis can be increased when Fenofibric acid is combined with Lovastatin.Approved
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Lovastatin.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Lovastatin.Approved
FinasterideThe metabolism of Finasteride can be decreased when combined with Lovastatin.Approved
FingolimodThe metabolism of Fingolimod can be decreased when combined with Lovastatin.Approved, Investigational
Fish oilThe metabolism of Fish oil can be decreased when combined with Lovastatin.Approved, Nutraceutical
FlibanserinThe risk or severity of adverse effects can be increased when Lovastatin is combined with Flibanserin.Approved, Investigational
FluconazoleThe serum concentration of Lovastatin can be increased when it is combined with Fluconazole.Approved, Investigational
FlunarizineThe metabolism of Flunarizine can be decreased when combined with Lovastatin.Approved
FlunisolideThe metabolism of Flunisolide can be decreased when combined with Lovastatin.Approved, Investigational
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Lovastatin.Approved, Illicit
FluorometholoneThe metabolism of Fluorometholone can be decreased when combined with Lovastatin.Approved, Investigational
FluoxetineThe serum concentration of Lovastatin can be increased when it is combined with Fluoxetine.Approved, Vet Approved
FlurazepamThe metabolism of Flurazepam can be decreased when combined with Lovastatin.Approved, Illicit, Investigational
FlurbiprofenThe metabolism of Flurbiprofen can be decreased when combined with Lovastatin.Approved, Investigational
FlurithromycinThe risk or severity of rhabdomyolysis can be increased when Flurithromycin is combined with Lovastatin.Experimental
FluspirileneThe metabolism of Fluspirilene can be decreased when combined with Lovastatin.Approved, Investigational
FlutamideThe metabolism of Flutamide can be decreased when combined with Lovastatin.Approved, Investigational
Fluticasone furoateThe metabolism of Fluticasone furoate can be decreased when combined with Lovastatin.Approved
Fluticasone propionateThe serum concentration of Fluticasone propionate can be increased when it is combined with Lovastatin.Approved
FluvastatinThe risk or severity of myopathy and rhabdomyolysis can be increased when Fluvastatin is combined with Lovastatin.Approved
FluvoxamineThe serum concentration of Lovastatin can be increased when it is combined with Fluvoxamine.Approved, Investigational
FormoterolThe metabolism of Formoterol can be decreased when combined with Lovastatin.Approved, Investigational
FosamprenavirThe serum concentration of Lovastatin can be increased when it is combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Lovastatin can be increased when it is combined with Fosaprepitant.Approved
FosnetupitantThe serum concentration of Lovastatin can be increased when it is combined with Fosnetupitant.Approved
FosphenytoinThe serum concentration of Lovastatin can be decreased when it is combined with Fosphenytoin.Approved, Investigational
FostamatinibThe metabolism of Fostamatinib can be decreased when combined with Lovastatin.Approved, Investigational
FulvestrantThe metabolism of Fulvestrant can be decreased when combined with Lovastatin.Approved, Investigational
Fusidic AcidThe serum concentration of Lovastatin can be increased when it is combined with Fusidic Acid.Approved, Investigational
GabapentinThe metabolism of Gabapentin can be decreased when combined with Lovastatin.Approved, Investigational
GabexateThe serum concentration of Lovastatin can be increased when it is combined with Gabexate.Investigational
GalantamineThe metabolism of Galantamine can be decreased when combined with Lovastatin.Approved
GallopamilThe serum concentration of Lovastatin can be increased when it is combined with Gallopamil.Investigational
GanciclovirThe risk or severity of myopathy and rhabdomyolysis can be increased when Ganciclovir is combined with Lovastatin.Approved, Investigational
GavestinelThe metabolism of Gavestinel can be decreased when combined with Lovastatin.Investigational
GefitinibThe metabolism of Gefitinib can be decreased when combined with Lovastatin.Approved, Investigational
GeldanamycinThe serum concentration of Lovastatin can be increased when it is combined with Geldanamycin.Experimental, Investigational
GemfibrozilThe risk or severity of rhabdomyolysis, myoglobinuria, and elevated creatine kinase (CPK) can be increased when Gemfibrozil is combined with Lovastatin.Approved
GliclazideThe metabolism of Gliclazide can be decreased when combined with Lovastatin.Approved
GlipizideThe metabolism of Glipizide can be decreased when combined with Lovastatin.Approved, Investigational
GlyburideThe serum concentration of Lovastatin can be increased when it is combined with Glyburide.Approved
GlycerinThe serum concentration of Lovastatin can be increased when it is combined with Glycerin.Approved, Investigational
Glycerol PhenylbutyrateThe serum concentration of Lovastatin can be increased when it is combined with Glycerol Phenylbutyrate.Approved
GM6001The serum concentration of Lovastatin can be increased when it is combined with GM6001.Experimental
GPI-1485The risk or severity of rhabdomyolysis can be increased when GPI-1485 is combined with Lovastatin.Investigational
GranisetronThe metabolism of Granisetron can be decreased when combined with Lovastatin.Approved, Investigational
GrazoprevirThe metabolism of Grazoprevir can be decreased when combined with Lovastatin.Approved
GrepafloxacinThe metabolism of Grepafloxacin can be decreased when combined with Lovastatin.Approved, Investigational, Withdrawn
GuanfacineThe metabolism of Guanfacine can be decreased when combined with Lovastatin.Approved, Investigational
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Lovastatin.Approved
HaloperidolThe serum concentration of Lovastatin can be increased when it is combined with Haloperidol.Approved
HalothaneThe metabolism of Halothane can be decreased when combined with Lovastatin.Approved, Vet Approved
HexobarbitalThe metabolism of Hexobarbital can be decreased when combined with Lovastatin.Approved
HistamineThe metabolism of Histamine can be decreased when combined with Lovastatin.Approved, Investigational
HydralazineThe serum concentration of Lovastatin can be increased when it is combined with Hydralazine.Approved
HydrocodoneThe metabolism of Hydrocodone can be decreased when combined with Lovastatin.Approved, Illicit
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with Lovastatin.Approved, Vet Approved
Hydrocortisone acetateThe metabolism of Hydrocortisone acetate can be decreased when combined with Lovastatin.Approved, Vet Approved
Hydrocortisone butyrateThe metabolism of Hydrocortisone butyrate can be decreased when combined with Lovastatin.Approved, Vet Approved
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Lovastatin.Approved, Illicit
HydrotalciteThe serum concentration of Lovastatin can be decreased when it is combined with Hydrotalcite.Approved, Experimental, Investigational
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be decreased when combined with Lovastatin.Approved, Investigational
IbandronateThe risk or severity of myopathy and rhabdomyolysis can be increased when Ibandronate is combined with Lovastatin.Approved, Investigational
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Lovastatin.Approved
IbuprofenThe serum concentration of Lovastatin can be increased when it is combined with Ibuprofen.Approved
IcotinibThe metabolism of Icotinib can be decreased when combined with Lovastatin.Approved, Investigational
IdarubicinThe metabolism of Idarubicin can be decreased when combined with Lovastatin.Approved
IdelalisibThe serum concentration of Lovastatin can be increased when it is combined with Idelalisib.Approved
IdraparinuxThe serum concentration of Lovastatin can be increased when it is combined with Idraparinux.Investigational
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Lovastatin resulting in a loss in efficacy.Approved
IloperidoneThe serum concentration of Lovastatin can be increased when it is combined with Iloperidone.Approved
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Lovastatin.Approved
ImidafenacinThe metabolism of Imidafenacin can be decreased when combined with Lovastatin.Approved, Investigational
ImidaprilThe serum concentration of Lovastatin can be increased when it is combined with Imidapril.Investigational
ImipramineThe metabolism of Imipramine can be decreased when combined with Lovastatin.Approved
ImiquimodThe metabolism of Imiquimod can be decreased when combined with Lovastatin.Approved, Investigational
IndacaterolThe metabolism of Indacaterol can be decreased when combined with Lovastatin.Approved
IndapamideThe metabolism of Indapamide can be decreased when combined with Lovastatin.Approved
IndinavirThe serum concentration of Lovastatin can be increased when it is combined with Indinavir.Approved
IndisulamThe serum concentration of Lovastatin can be increased when it is combined with Indisulam.Investigational
IndomethacinThe metabolism of Indomethacin can be decreased when combined with Lovastatin.Approved, Investigational
IpecacThe metabolism of Ipecac can be decreased when combined with Lovastatin.Approved, Withdrawn
IpratropiumThe metabolism of Ipratropium can be decreased when combined with Lovastatin.Approved
IrbesartanThe serum concentration of Lovastatin can be increased when it is combined with Irbesartan.Approved, Investigational
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Lovastatin.Approved, Investigational
IsavuconazoleThe serum concentration of Lovastatin can be increased when it is combined with Isavuconazole.Approved, Investigational
IsavuconazoniumThe serum concentration of Lovastatin can be increased when it is combined with Isavuconazonium.Approved, Investigational
IsoflurophateThe serum concentration of Lovastatin can be increased when it is combined with Isoflurophate.Approved, Investigational, Withdrawn
IsoniazidThe serum concentration of Lovastatin can be increased when it is combined with Isoniazid.Approved, Investigational
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be decreased when combined with Lovastatin.Approved, Investigational
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be decreased when combined with Lovastatin.Approved
IsradipineThe serum concentration of Lovastatin can be increased when it is combined with Isradipine.Approved, Investigational
ItraconazoleThe serum concentration of Lovastatin can be increased when it is combined with Itraconazole.Approved, Investigational
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Lovastatin.Approved
IvacaftorThe serum concentration of Ivacaftor can be increased when it is combined with Lovastatin.Approved
IvermectinThe risk or severity of rhabdomyolysis can be increased when Ivermectin is combined with Lovastatin.Approved, Investigational, Vet Approved
IxabepiloneThe risk or severity of rhabdomyolysis can be increased when Ixabepilone is combined with Lovastatin.Approved, Investigational
IxazomibThe serum concentration of Lovastatin can be increased when it is combined with Ixazomib.Approved, Investigational
JosamycinThe serum concentration of Lovastatin can be increased when it is combined with Josamycin.Approved, Investigational
KetamineThe metabolism of Ketamine can be decreased when combined with Lovastatin.Approved, Vet Approved
KetazolamThe serum concentration of Lovastatin can be increased when it is combined with Ketazolam.Approved
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Lovastatin.Approved, Investigational
KetoconazoleThe serum concentration of Lovastatin can be increased when it is combined with Ketoconazole.Approved, Investigational
KetoprofenThe metabolism of Ketoprofen can be decreased when combined with Lovastatin.Approved, Vet Approved
KitasamycinThe risk or severity of rhabdomyolysis can be increased when Kitasamycin is combined with Lovastatin.Experimental
KOS-1584The risk or severity of rhabdomyolysis can be increased when KOS-1584 is combined with Lovastatin.Investigational
LacidipineThe metabolism of Lacidipine can be decreased when combined with Lovastatin.Approved, Investigational
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Lovastatin.Approved, Investigational
LamotrigineThe serum concentration of Lovastatin can be decreased when it is combined with Lamotrigine.Approved, Investigational
LansoprazoleThe serum concentration of Lovastatin can be increased when it is combined with Lansoprazole.Approved, Investigational
Lanthanum carbonateThe serum concentration of Lovastatin can be decreased when it is combined with Lanthanum carbonate.Approved
LapatinibThe serum concentration of Lovastatin can be increased when it is combined with Lapatinib.Approved, Investigational
LaquinimodThe metabolism of Laquinimod can be decreased when combined with Lovastatin.Investigational
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Lovastatin.Approved
LeflunomideThe metabolism of Leflunomide can be decreased when combined with Lovastatin.Approved, Investigational
LenvatinibThe metabolism of Lenvatinib can be decreased when combined with Lovastatin.Approved, Investigational
LepirudinThe serum concentration of Lovastatin can be increased when it is combined with Lepirudin.Approved
LercanidipineThe risk or severity of myopathy and rhabdomyolysis can be increased when Lercanidipine is combined with Lovastatin.Approved, Investigational
LesinuradThe metabolism of Lesinurad can be decreased when combined with Lovastatin.Approved, Investigational
LetaxabanThe serum concentration of Lovastatin can be increased when it is combined with Letaxaban.Investigational
LetrozoleThe metabolism of Letrozole can be decreased when combined with Lovastatin.Approved, Investigational
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Lovastatin.Approved, Investigational
LevobupivacaineThe metabolism of Levobupivacaine can be decreased when combined with Lovastatin.Approved, Investigational
LevocetirizineThe metabolism of Levocetirizine can be decreased when combined with Lovastatin.Approved
LevofloxacinThe serum concentration of Lovastatin can be increased when it is combined with Levofloxacin.Approved, Investigational
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be decreased when combined with Lovastatin.Approved, Investigational
LevomilnacipranThe metabolism of Levomilnacipran can be decreased when combined with Lovastatin.Approved, Investigational
LevonorgestrelThe metabolism of Levonorgestrel can be decreased when combined with Lovastatin.Approved, Investigational
LevosalbutamolThe serum concentration of Lovastatin can be increased when it is combined with Levosalbutamol.Approved, Investigational
LevothyroxineThe metabolism of Levothyroxine can be decreased when combined with Lovastatin.Approved
LicofeloneThe metabolism of Licofelone can be decreased when combined with Lovastatin.Investigational
LidocaineThe serum concentration of Lovastatin can be increased when it is combined with Lidocaine.Approved, Vet Approved
LidoflazineThe metabolism of Lidoflazine can be decreased when combined with Lovastatin.Experimental
LinagliptinThe serum concentration of Lovastatin can be increased when it is combined with Linagliptin.Approved
LipegfilgrastimLovastatin may increase the myelosuppressive activities of Lipegfilgrastim.Approved, Investigational
LisinoprilThe serum concentration of Lovastatin can be increased when it is combined with Lisinopril.Approved, Investigational
LisurideThe risk or severity of adverse effects can be increased when Lisuride is combined with Lovastatin.Approved, Investigational
LomerizineThe serum concentration of Lovastatin can be increased when it is combined with Lomerizine.Experimental
LomitapideThe serum concentration of Lovastatin can be increased when it is combined with Lomitapide.Approved, Investigational
LomustineThe serum concentration of Lovastatin can be increased when it is combined with Lomustine.Approved, Investigational
LoperamideThe serum concentration of Loperamide can be increased when it is combined with Lovastatin.Approved
LopinavirThe serum concentration of Lovastatin can be increased when it is combined with Lopinavir.Approved
LoratadineThe serum concentration of Lovastatin can be increased when it is combined with Loratadine.Approved, Investigational
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Lovastatin.Approved
LornoxicamThe metabolism of Lornoxicam can be decreased when combined with Lovastatin.Approved, Investigational
LorpiprazoleThe serum concentration of Lovastatin can be increased when it is combined with Lorpiprazole.Approved
Lorvotuzumab mertansineThe risk or severity of rhabdomyolysis can be increased when Lorvotuzumab mertansine is combined with Lovastatin.Investigational
LosartanThe serum concentration of Losartan can be increased when it is combined with Lovastatin.Approved
LuliconazoleThe serum concentration of Lovastatin can be increased when it is combined with Luliconazole.Approved
LumacaftorThe metabolism of Lovastatin can be increased when combined with Lumacaftor.Approved
LumefantrineThe metabolism of Lumefantrine can be decreased when combined with Lovastatin.Approved
LumiracoxibThe metabolism of Lumiracoxib can be decreased when combined with Lovastatin.Approved, Investigational
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Lovastatin.Approved, Investigational
Lysergic Acid DiethylamideThe risk or severity of adverse effects can be increased when Lysergic Acid Diethylamide is combined with Lovastatin.Illicit, Investigational, Withdrawn
MacimorelinThe metabolism of Macimorelin can be decreased when combined with Lovastatin.Approved, Investigational
MacitentanThe metabolism of Macitentan can be decreased when combined with Lovastatin.Approved
MagaldrateThe serum concentration of Lovastatin can be decreased when it is combined with Magaldrate.Approved, Withdrawn
Magnesium oxideThe serum concentration of Lovastatin can be decreased when it is combined with Magnesium oxide.Approved
Magnesium peroxideThe serum concentration of Lovastatin can be decreased when it is combined with Magnesium peroxide.Experimental
Magnesium silicateThe serum concentration of Lovastatin can be decreased when it is combined with Magnesium silicate.Approved
Magnesium sulfateThe metabolism of Magnesium sulfate can be decreased when combined with Lovastatin.Approved, Investigational, Vet Approved
ManidipineThe metabolism of Manidipine can be decreased when combined with Lovastatin.Approved, Investigational
MaravirocThe metabolism of Maraviroc can be decreased when combined with Lovastatin.Approved, Investigational
MebendazoleThe metabolism of Mebendazole can be decreased when combined with Lovastatin.Approved, Vet Approved
Medical CannabisThe metabolism of Medical Cannabis can be decreased when combined with Lovastatin.Experimental, Investigational
Medroxyprogesterone acetateThe metabolism of Medroxyprogesterone acetate can be decreased when combined with Lovastatin.Approved, Investigational
Mefenamic acidThe metabolism of Mefenamic acid can be decreased when combined with Lovastatin.Approved
MefloquineThe serum concentration of Lovastatin can be increased when it is combined with Mefloquine.Approved, Investigational
MelagatranThe serum concentration of Lovastatin can be increased when it is combined with Melagatran.Experimental
MelatoninThe metabolism of Melatonin can be decreased when combined with Lovastatin.Approved, Nutraceutical, Vet Approved
MeloxicamThe metabolism of Meloxicam can be decreased when combined with Lovastatin.Approved, Vet Approved
MentholThe metabolism of Menthol can be decreased when combined with Lovastatin.Approved
MepartricinThe risk or severity of rhabdomyolysis can be increased when Mepartricin is combined with Lovastatin.Experimental
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Lovastatin.Investigational, Withdrawn
MequitazineThe serum concentration of Lovastatin can be increased when it is combined with Mequitazine.Approved
MestranolThe metabolism of Mestranol can be decreased when combined with Lovastatin.Approved
MetergolineThe risk or severity of adverse effects can be increased when Metergoline is combined with Lovastatin.Experimental
MethadoneThe serum concentration of Lovastatin can be increased when it is combined with Methadone.Approved
MethaqualoneThe metabolism of Methaqualone can be decreased when combined with Lovastatin.Illicit, Withdrawn
MethazolamideThe serum concentration of Lovastatin can be increased when it is combined with Methazolamide.Approved
MethoxsalenThe metabolism of Methoxsalen can be decreased when combined with Lovastatin.Approved
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Lovastatin.Approved, Investigational, Vet Approved
MethylergometrineThe serum concentration of Lovastatin can be increased when it is combined with Methylergometrine.Approved
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Lovastatin.Approved, Vet Approved
MethyltestosteroneThe metabolism of Methyltestosterone can be decreased when combined with Lovastatin.Approved
MethysergideThe risk or severity of adverse effects can be increased when Methysergide is combined with Lovastatin.Approved
MetoclopramideThe risk or severity of myopathy and rhabdomyolysis can be increased when Metoclopramide is combined with Lovastatin.Approved, Investigational
MetronidazoleThe serum concentration of Lovastatin can be increased when it is combined with Metronidazole.Approved
MetyraponeThe serum concentration of Lovastatin can be increased when it is combined with Metyrapone.Approved, Investigational
MevastatinThe serum concentration of Mevastatin can be increased when it is combined with Lovastatin.Experimental
MexiletineThe metabolism of Mexiletine can be decreased when combined with Lovastatin.Approved, Investigational
MianserinThe metabolism of Mianserin can be decreased when combined with Lovastatin.Approved, Investigational
MibefradilThe serum concentration of Lovastatin can be increased when it is combined with Mibefradil.Investigational, Withdrawn
MiconazoleThe serum concentration of Lovastatin can be increased when it is combined with Miconazole.Approved, Investigational, Vet Approved
MidazolamThe serum concentration of Lovastatin can be increased when it is combined with Midazolam.Approved, Illicit
MidecamycinThe risk or severity of rhabdomyolysis can be increased when Midecamycin is combined with Lovastatin.Approved
MidostaurinThe metabolism of Midostaurin can be decreased when combined with Lovastatin.Approved, Investigational
MifepristoneThe serum concentration of Lovastatin can be increased when it is combined with Mifepristone.Approved, Investigational
MiocamycinThe risk or severity of rhabdomyolysis can be increased when Miocamycin is combined with Lovastatin.Experimental
MirabegronThe metabolism of Mirabegron can be decreased when combined with Lovastatin.Approved
MirtazapineThe serum concentration of Lovastatin can be increased when it is combined with Mirtazapine.Approved
Mirvetuximab SoravtansineThe risk or severity of rhabdomyolysis can be increased when Mirvetuximab Soravtansine is combined with Lovastatin.Investigational
MitemcinalThe risk or severity of rhabdomyolysis can be increased when Mitemcinal is combined with Lovastatin.Investigational
MitotaneThe serum concentration of Lovastatin can be decreased when it is combined with Mitotane.Approved
MitoxantroneThe serum concentration of Lovastatin can be increased when it is combined with Mitoxantrone.Approved, Investigational
MoclobemideThe metabolism of Moclobemide can be decreased when combined with Lovastatin.Approved, Investigational
ModafinilThe serum concentration of Lovastatin can be increased when it is combined with Modafinil.Approved, Investigational
MoexiprilThe serum concentration of Lovastatin can be increased when it is combined with Moexipril.Approved
MontelukastThe metabolism of Montelukast can be decreased when combined with Lovastatin.Approved
MorphineThe metabolism of Morphine can be decreased when combined with Lovastatin.Approved, Investigational
Mycophenolate mofetilThe metabolism of Mycophenolate mofetil can be decreased when combined with Lovastatin.Approved, Investigational
N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-ProlineThe serum concentration of Lovastatin can be increased when it is combined with N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-Proline.Experimental
NabiloneThe serum concentration of Lovastatin can be increased when it is combined with Nabilone.Approved, Investigational
NabiximolsThe metabolism of Nabiximols can be decreased when combined with Lovastatin.Approved, Investigational
NafamostatThe serum concentration of Lovastatin can be increased when it is combined with Nafamostat.Approved, Investigational
NaftopidilThe metabolism of Naftopidil can be decreased when combined with Lovastatin.Investigational
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Lovastatin.Approved
NaloxoneThe metabolism of Naloxone can be decreased when combined with Lovastatin.Approved, Vet Approved
NatamycinThe risk or severity of rhabdomyolysis can be increased when Natamycin is combined with Lovastatin.Approved
NateglinideThe metabolism of Nateglinide can be decreased when combined with Lovastatin.Approved, Investigational
NefazodoneThe serum concentration of Lovastatin can be increased when it is combined with Nefazodone.Approved, Withdrawn
NelfinavirThe serum concentration of Lovastatin can be increased when it is combined with Nelfinavir.Approved
NeratinibThe metabolism of Neratinib can be decreased when combined with Lovastatin.Approved, Investigational
NetupitantThe serum concentration of Lovastatin can be increased when it is combined with Netupitant.Approved, Investigational
NevirapineThe serum concentration of Lovastatin can be increased when it is combined with Nevirapine.Approved
NiacinThe risk or severity of rhabdomyolysis can be increased when Niacin is combined with Lovastatin.Approved, Investigational, Nutraceutical
NicardipineThe serum concentration of Lovastatin can be increased when it is combined with Nicardipine.Approved, Investigational
NicergolineThe risk or severity of adverse effects can be increased when Nicergoline is combined with Lovastatin.Approved, Investigational
NiclosamideThe metabolism of Niclosamide can be decreased when combined with Lovastatin.Approved, Investigational, Vet Approved
NicotinamideThe serum concentration of Lovastatin can be increased when it is combined with Nicotinamide.Approved, Investigational
NicotineThe metabolism of Nicotine can be decreased when combined with Lovastatin.Approved
NifedipineThe serum concentration of Nifedipine can be increased when it is combined with Lovastatin.Approved
NiguldipineThe serum concentration of Lovastatin can be increased when it is combined with Niguldipine.Experimental
NilotinibThe serum concentration of Lovastatin can be increased when it is combined with Nilotinib.Approved, Investigational
NiludipineThe metabolism of Niludipine can be decreased when combined with Lovastatin.Experimental
NilvadipineThe metabolism of Nilvadipine can be decreased when combined with Lovastatin.Approved, Investigational
NimesulideThe metabolism of Nimesulide can be decreased when combined with Lovastatin.Approved, Investigational, Withdrawn
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Lovastatin.Approved, Investigational
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Lovastatin.Approved
NisoldipineThe serum concentration of Lovastatin can be increased when it is combined with Nisoldipine.Approved
NitrazepamThe metabolism of Nitrazepam can be decreased when combined with Lovastatin.Approved
NitrendipineThe serum concentration of Lovastatin can be increased when it is combined with Nitrendipine.Approved, Investigational
Nitric OxideThe serum concentration of Lovastatin can be increased when it is combined with Nitric Oxide.Approved
NorethisteroneThe metabolism of Norethisterone can be decreased when combined with Lovastatin.Approved
NorfloxacinThe serum concentration of Lovastatin can be increased when it is combined with Norfloxacin.Approved
NorgestrelThe metabolism of Norgestrel can be decreased when combined with Lovastatin.Approved
NortriptylineThe metabolism of Nortriptyline can be decreased when combined with Lovastatin.Approved
NoscapineThe serum concentration of Lovastatin can be increased when it is combined with Noscapine.Investigational
NylidrinThe metabolism of Nylidrin can be decreased when combined with Lovastatin.Approved
NystatinThe excretion of Lovastatin can be decreased when combined with Nystatin.Approved, Vet Approved
OdanacatibThe metabolism of Odanacatib can be decreased when combined with Lovastatin.Investigational
OlanzapineThe serum concentration of Lovastatin can be increased when it is combined with Olanzapine.Approved, Investigational
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Lovastatin.Approved
OleandomycinThe risk or severity of rhabdomyolysis can be increased when Oleandomycin is combined with Lovastatin.Vet Approved
OlodaterolThe metabolism of Olodaterol can be decreased when combined with Lovastatin.Approved
OlopatadineThe metabolism of Olopatadine can be decreased when combined with Lovastatin.Approved
OmapatrilatThe serum concentration of Lovastatin can be increased when it is combined with Omapatrilat.Investigational
OmeprazoleThe serum concentration of Omeprazole can be increased when it is combined with Lovastatin.Approved, Investigational, Vet Approved
OndansetronThe serum concentration of Ondansetron can be increased when it is combined with Lovastatin.Approved
OpiumThe metabolism of Opium can be decreased when combined with Lovastatin.Approved, Illicit
OrphenadrineThe metabolism of Orphenadrine can be decreased when combined with Lovastatin.Approved
OsimertinibThe serum concentration of Lovastatin can be increased when it is combined with Osimertinib.Approved
OspemifeneThe metabolism of Ospemifene can be decreased when combined with Lovastatin.Approved, Investigational
OtamixabanThe serum concentration of Lovastatin can be increased when it is combined with Otamixaban.Investigational
OtiloniumThe metabolism of Otilonium can be decreased when combined with Lovastatin.Experimental, Investigational
OxaprozinThe metabolism of Oxaprozin can be decreased when combined with Lovastatin.Approved
OxazepamThe metabolism of Oxazepam can be decreased when combined with Lovastatin.Approved
OxetacaineThe serum concentration of Lovastatin can be increased when it is combined with Oxetacaine.Approved, Investigational
OxybutyninThe serum concentration of Lovastatin can be increased when it is combined with Oxybutynin.Approved, Investigational
OxycodoneThe risk or severity of adverse effects can be increased when Lovastatin is combined with Oxycodone.Approved, Illicit, Investigational
OxymetholoneThe serum concentration of Lovastatin can be increased when it is combined with Oxymetholone.Approved, Illicit
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Lovastatin.Approved, Investigational, Vet Approved
PaclitaxelThe serum concentration of Lovastatin can be increased when it is combined with Paclitaxel.Approved, Vet Approved
PalbociclibThe serum concentration of Lovastatin can be increased when it is combined with Palbociclib.Approved, Investigational
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Lovastatin.Approved, Investigational
PanobinostatThe metabolism of Panobinostat can be decreased when combined with Lovastatin.Approved, Investigational
PantoprazoleThe metabolism of Pantoprazole can be decreased when combined with Lovastatin.Approved
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Lovastatin.Approved
ParamethasoneThe serum concentration of Lovastatin can be increased when it is combined with Paramethasone.Approved
ParecoxibThe metabolism of Parecoxib can be decreased when combined with Lovastatin.Approved
ParicalcitolThe metabolism of Paricalcitol can be decreased when combined with Lovastatin.Approved, Investigational
ParitaprevirThe metabolism of Paritaprevir can be decreased when combined with Lovastatin.Approved, Investigational
ParoxetineThe serum concentration of Lovastatin can be increased when it is combined with Paroxetine.Approved, Investigational
PatupiloneThe risk or severity of rhabdomyolysis can be increased when Patupilone is combined with Lovastatin.Experimental, Investigational
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Lovastatin.Approved
PenfluridolThe metabolism of Penfluridol can be decreased when combined with Lovastatin.Experimental
PentamidineThe metabolism of Pentamidine can be decreased when combined with Lovastatin.Approved, Investigational
PentobarbitalThe metabolism of Lovastatin can be increased when combined with Pentobarbital.Approved, Investigational, Vet Approved
Peppermint oilThe serum concentration of Lovastatin can be increased when it is combined with Peppermint oil.Approved, Investigational
PerampanelThe metabolism of Perampanel can be decreased when combined with Lovastatin.Approved
PergolideThe serum concentration of Lovastatin can be increased when it is combined with Pergolide.Approved, Investigational, Vet Approved, Withdrawn
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Lovastatin.Approved, Investigational
PerindoprilThe serum concentration of Lovastatin can be increased when it is combined with Perindopril.Approved
PermethrinThe metabolism of Permethrin can be decreased when combined with Lovastatin.Approved, Investigational
PerospironeThe metabolism of Perospirone can be decreased when combined with Lovastatin.Approved
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Lovastatin.Approved
PethidineThe metabolism of Pethidine can be decreased when combined with Lovastatin.Approved
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Lovastatin.Withdrawn
PhenelzineThe serum concentration of Lovastatin can be increased when it is combined with Phenelzine.Approved
PhenobarbitalThe serum concentration of Lovastatin can be decreased when it is combined with Phenobarbital.Approved, Investigational
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be decreased when combined with Lovastatin.Approved
PhenprocoumonThe metabolism of Phenprocoumon can be decreased when combined with Lovastatin.Approved, Investigational
PhenylbutazoneThe metabolism of Phenylbutazone can be decreased when combined with Lovastatin.Approved, Vet Approved
PhenytoinThe serum concentration of Lovastatin can be decreased when it is combined with Phenytoin.Approved, Vet Approved
PhosphoramidonThe serum concentration of Lovastatin can be increased when it is combined with Phosphoramidon.Experimental
PilocarpineThe serum concentration of Lovastatin can be increased when it is combined with Pilocarpine.Approved, Investigational
PimecrolimusThe metabolism of Pimecrolimus can be decreased when combined with Lovastatin.Approved, Investigational
PimozideThe serum concentration of Pimozide can be increased when it is combined with Lovastatin.Approved
PinacidilThe metabolism of Pinacidil can be decreased when combined with Lovastatin.Approved
PinaveriumThe metabolism of Pinaverium can be decreased when combined with Lovastatin.Approved
PioglitazoneThe metabolism of Pioglitazone can be decreased when combined with Lovastatin.Approved, Investigational
PiperaquineThe serum concentration of Lovastatin can be increased when it is combined with Piperaquine.Approved, Investigational
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Lovastatin.Approved, Investigational
PiroxicamThe metabolism of Piroxicam can be decreased when combined with Lovastatin.Approved, Investigational
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Lovastatin.Approved
PitolisantThe serum concentration of Pitolisant can be increased when it is combined with Lovastatin.Approved, Investigational
PodofiloxThe metabolism of Podofilox can be decreased when combined with Lovastatin.Approved
PomalidomideThe metabolism of Pomalidomide can be decreased when combined with Lovastatin.Approved
PonatinibThe metabolism of Ponatinib can be decreased when combined with Lovastatin.Approved, Investigational
PosaconazoleThe serum concentration of Lovastatin can be increased when it is combined with Posaconazole.Approved, Investigational, Vet Approved
PrasteroneThe metabolism of Prasterone can be decreased when combined with Lovastatin.Approved, Investigational, Nutraceutical
PrasugrelThe metabolism of Prasugrel can be decreased when combined with Lovastatin.Approved
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Lovastatin.Approved
PrazepamThe metabolism of Prazepam can be decreased when combined with Lovastatin.Approved, Illicit
PraziquantelThe metabolism of Praziquantel can be decreased when combined with Lovastatin.Approved, Investigational, Vet Approved
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Lovastatin.Approved, Vet Approved
PrednisoneThe serum concentration of Lovastatin can be increased when it is combined with Prednisone.Approved, Vet Approved
PregabalinThe metabolism of Pregabalin can be decreased when combined with Lovastatin.Approved, Illicit, Investigational
PrenylamineThe metabolism of Prenylamine can be decreased when combined with Lovastatin.Withdrawn
PrimaquineThe serum concentration of Lovastatin can be increased when it is combined with Primaquine.Approved
PrimidoneThe metabolism of Lovastatin can be increased when combined with Primidone.Approved, Vet Approved
PrinomastatThe serum concentration of Lovastatin can be increased when it is combined with Prinomastat.Investigational
ProchlorperazineThe metabolism of Prochlorperazine can be decreased when combined with Lovastatin.Approved, Vet Approved
ProgesteroneThe serum concentration of Lovastatin can be increased when it is combined with Progesterone.Approved, Vet Approved
ProguanilThe metabolism of Proguanil can be decreased when combined with Lovastatin.Approved
PromazineThe metabolism of Promazine can be decreased when combined with Lovastatin.Approved, Vet Approved
PromethazineThe serum concentration of Lovastatin can be increased when it is combined with Promethazine.Approved, Investigational
PropiverineThe metabolism of Propiverine can be decreased when combined with Lovastatin.Approved, Investigational
PropofolThe serum concentration of Lovastatin can be increased when it is combined with Propofol.Approved, Investigational, Vet Approved
PropranololThe serum concentration of Propranolol can be increased when it is combined with Lovastatin.Approved, Investigational
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Lovastatin.Approved
PyrazinamideThe metabolism of Pyrazinamide can be decreased when combined with Lovastatin.Approved, Investigational
QuazepamThe metabolism of Quazepam can be decreased when combined with Lovastatin.Approved, Illicit
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Lovastatin.Approved
QuinacrineThe metabolism of Quinacrine can be decreased when combined with Lovastatin.Approved, Investigational
QuinaprilThe serum concentration of Lovastatin can be increased when it is combined with Quinapril.Approved, Investigational
QuinidineThe serum concentration of Lovastatin can be increased when it is combined with Quinidine.Approved, Investigational
QuinineThe serum concentration of Lovastatin can be increased when it is combined with Quinine.Approved
QuinupristinThe serum concentration of Lovastatin can be increased when it is combined with Quinupristin.Approved
RabeprazoleThe serum concentration of Lovastatin can be increased when it is combined with Rabeprazole.Approved, Investigational
RacecadotrilThe serum concentration of Lovastatin can be increased when it is combined with Racecadotril.Investigational
RaloxifeneThe serum concentration of Lovastatin can be increased when it is combined with Raloxifene.Approved, Investigational
RaltegravirRaltegravir may increase the myopathic rhabdomyolysis activities of Lovastatin.Approved
RamelteonThe metabolism of Ramelteon can be decreased when combined with Lovastatin.Approved, Investigational
RamiprilThe serum concentration of Lovastatin can be increased when it is combined with Ramipril.Approved
RanitidineThe serum concentration of Lovastatin can be increased when it is combined with Ranitidine.Approved
RanolazineThe risk or severity of myopathy and rhabdomyolysis can be increased when Ranolazine is combined with Lovastatin.Approved, Investigational
ReboxetineThe metabolism of Reboxetine can be decreased when combined with Lovastatin.Approved, Investigational
RegorafenibThe serum concentration of Lovastatin can be increased when it is combined with Regorafenib.Approved
RemikirenThe serum concentration of Lovastatin can be increased when it is combined with Remikiren.Approved
RepaglinideThe serum concentration of Lovastatin can be increased when it is combined with Repaglinide.Approved, Investigational
ResveratrolThe serum concentration of Lovastatin can be increased when it is combined with Resveratrol.Approved, Experimental, Investigational
RetapamulinThe metabolism of Retapamulin can be decreased when combined with Lovastatin.Approved
RibociclibThe serum concentration of Lovastatin can be increased when it is combined with Ribociclib.Approved, Investigational
RidaforolimusThe risk or severity of rhabdomyolysis can be increased when Ridaforolimus is combined with Lovastatin.Investigational
RifabutinThe metabolism of Lovastatin can be increased when combined with Rifabutin.Approved, Investigational
RifampicinThe serum concentration of Lovastatin can be decreased when it is combined with Rifampicin.Approved
RifapentineThe metabolism of Lovastatin can be increased when combined with Rifapentine.Approved, Investigational
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Lovastatin.Approved, Investigational
RilpivirineThe serum concentration of Rilpivirine can be increased when it is combined with Lovastatin.Approved
RimonabantThe metabolism of Rimonabant can be decreased when combined with Lovastatin.Approved, Investigational
RiociguatThe metabolism of Riociguat can be decreased when combined with Lovastatin.Approved
RisperidoneThe serum concentration of Lovastatin can be increased when it is combined with Risperidone.Approved, Investigational
RitonavirThe serum concentration of Lovastatin can be increased when it is combined with Ritonavir.Approved, Investigational
RivaroxabanThe serum concentration of Lovastatin can be increased when it is combined with Rivaroxaban.Approved
RivastigmineThe serum concentration of Lovastatin can be increased when it is combined with Rivastigmine.Approved, Investigational
RofecoxibThe metabolism of Rofecoxib can be decreased when combined with Lovastatin.Approved, Investigational, Withdrawn
RokitamycinThe risk or severity of rhabdomyolysis can be increased when Rokitamycin is combined with Lovastatin.Experimental
RolapitantThe metabolism of Rolapitant can be decreased when combined with Lovastatin.Approved, Investigational
RolitetracyclineThe serum concentration of Lovastatin can be increased when it is combined with Rolitetracycline.Approved
RomidepsinThe metabolism of Romidepsin can be decreased when combined with Lovastatin.Approved, Investigational
RopiniroleThe metabolism of Ropinirole can be decreased when combined with Lovastatin.Approved, Investigational
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Lovastatin.Approved
RosiglitazoneThe metabolism of Rosiglitazone can be decreased when combined with Lovastatin.Approved, Investigational
RosuvastatinThe risk or severity of myopathy and rhabdomyolysis can be increased when Lovastatin is combined with Rosuvastatin.Approved
RotigotineThe metabolism of Rotigotine can be decreased when combined with Lovastatin.Approved
RoxithromycinThe serum concentration of Lovastatin can be increased when it is combined with Roxithromycin.Approved, Investigational, Withdrawn
RucaparibThe serum concentration of Lovastatin can be increased when it is combined with Rucaparib.Approved, Investigational
RupatadineThe metabolism of Rupatadine can be decreased when combined with Lovastatin.Approved
RutinThe serum concentration of Lovastatin can be increased when it is combined with Rutin.Experimental, Investigational
RuxolitinibThe metabolism of Ruxolitinib can be decreased when combined with Lovastatin.Approved
S-3304The serum concentration of Lovastatin can be increased when it is combined with S-3304.Investigational
SafinamideThe metabolism of Safinamide can be decreased when combined with Lovastatin.Approved, Investigational
SagopiloneThe risk or severity of rhabdomyolysis can be increased when Sagopilone is combined with Lovastatin.Investigational
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Lovastatin.Approved
SaquinavirThe serum concentration of Lovastatin can be increased when it is combined with Saquinavir.Approved, Investigational
SarilumabThe therapeutic efficacy of Lovastatin can be decreased when used in combination with Sarilumab.Approved, Investigational
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Lovastatin.Approved
SelamectinThe risk or severity of rhabdomyolysis can be increased when Selamectin is combined with Lovastatin.Vet Approved
SelegilineThe metabolism of Selegiline can be decreased when combined with Lovastatin.Approved, Investigational, Vet Approved
SeletracetamThe metabolism of Seletracetam can be decreased when combined with Lovastatin.Investigational
SelexipagThe metabolism of Selexipag can be decreased when combined with Lovastatin.Approved
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Lovastatin.Approved
SertindoleThe metabolism of Sertindole can be decreased when combined with Lovastatin.Approved, Investigational, Withdrawn
SertralineThe serum concentration of Lovastatin can be increased when it is combined with Sertraline.Approved
SevofluraneThe metabolism of Sevoflurane can be decreased when combined with Lovastatin.Approved, Vet Approved
SibutramineThe metabolism of Sibutramine can be decreased when combined with Lovastatin.Approved, Illicit, Investigational, Withdrawn
SildenafilThe serum concentration of Lovastatin can be increased when it is combined with Sildenafil.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Lovastatin.Approved
SiltuximabThe serum concentration of Lovastatin can be decreased when it is combined with Siltuximab.Approved, Investigational
SimeprevirThe serum concentration of Lovastatin can be increased when it is combined with Simeprevir.Approved
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Lovastatin.Approved
SirolimusThe serum concentration of Lovastatin can be increased when it is combined with Sirolimus.Approved, Investigational
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with Lovastatin.Approved, Investigational
SitaxentanThe serum concentration of Lovastatin can be increased when it is combined with Sitaxentan.Approved, Investigational, Withdrawn
SivelestatThe serum concentration of Lovastatin can be increased when it is combined with Sivelestat.Investigational
Sodium bicarbonateThe serum concentration of Lovastatin can be decreased when it is combined with Sodium bicarbonate.Approved
SolifenacinThe metabolism of Solifenacin can be decreased when combined with Lovastatin.Approved
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Lovastatin.Approved, Investigational
SorafenibThe serum concentration of Lovastatin can be increased when it is combined with Sorafenib.Approved, Investigational
SpiramycinThe risk or severity of rhabdomyolysis can be increased when Spiramycin is combined with Lovastatin.Approved
SpiraprilThe serum concentration of Lovastatin can be increased when it is combined with Spirapril.Approved
St. John's WortThe metabolism of Lovastatin can be increased when combined with St. John's Wort.Approved, Investigational, Nutraceutical
StiripentolThe serum concentration of Lovastatin can be increased when it is combined with Stiripentol.Approved
SufentanilThe metabolism of Sufentanil can be decreased when combined with Lovastatin.Approved, Investigational
SulfadiazineThe metabolism of Sulfadiazine can be decreased when combined with Lovastatin.Approved, Investigational, Vet Approved
SulfamethoxazoleThe serum concentration of Lovastatin can be increased when it is combined with Sulfamethoxazole.Approved
SulfamoxoleThe metabolism of Sulfamoxole can be decreased when combined with Lovastatin.Approved
SulfanilamideThe serum concentration of Lovastatin can be increased when it is combined with Sulfanilamide.Approved
SulfasalazineThe excretion of Lovastatin can be decreased when combined with Sulfasalazine.Approved
SulfinpyrazoneThe serum concentration of Lovastatin can be increased when it is combined with Sulfinpyrazone.Approved
SulfisoxazoleThe serum concentration of Lovastatin can be increased when it is combined with Sulfisoxazole.Approved, Vet Approved
SumatriptanThe serum concentration of Sumatriptan can be increased when it is combined with Lovastatin.Approved, Investigational
SunitinibThe metabolism of Sunitinib can be decreased when combined with Lovastatin.Approved, Investigational
SuprofenThe metabolism of Suprofen can be decreased when combined with Lovastatin.Approved, Withdrawn
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Lovastatin.Approved, Investigational
Synthetic Conjugated Estrogens, AThe metabolism of Synthetic Conjugated Estrogens, A can be decreased when combined with Lovastatin.Approved
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be decreased when combined with Lovastatin.Approved
TacrolimusThe serum concentration of Lovastatin can be increased when it is combined with Tacrolimus.Approved, Investigational
TadalafilThe serum concentration of Lovastatin can be increased when it is combined with Tadalafil.Approved, Investigational
TamoxifenThe serum concentration of Lovastatin can be increased when it is combined with Tamoxifen.Approved
TamsulosinThe metabolism of Tamsulosin can be decreased when combined with Lovastatin.Approved, Investigational
TapentadolThe metabolism of Tapentadol can be decreased when combined with Lovastatin.Approved
TasosartanThe metabolism of Tasosartan can be decreased when combined with Lovastatin.Approved
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be decreased when combined with Lovastatin.Experimental
TelaprevirThe serum concentration of Lovastatin can be increased when it is combined with Telaprevir.Approved, Withdrawn
TelithromycinThe serum concentration of Lovastatin can be increased when it is combined with Telithromycin.Approved
TemazepamThe metabolism of Temazepam can be decreased when combined with Lovastatin.Approved, Investigational
TemocaprilThe serum concentration of Lovastatin can be increased when it is combined with Temocapril.Experimental, Investigational
TemsirolimusThe serum concentration of Lovastatin can be increased when it is combined with Temsirolimus.Approved
TeniposideThe serum concentration of Lovastatin can be increased when it is combined with Teniposide.Approved
TenoxicamThe metabolism of Tenoxicam can be decreased when combined with Lovastatin.Approved
TerbinafineThe risk or severity of myopathy and rhabdomyolysis can be increased when Terbinafine is combined with Lovastatin.Approved, Investigational, Vet Approved
TerfenadineThe serum concentration of Lovastatin can be increased when it is combined with Terfenadine.Approved, Withdrawn
TergurideThe risk or severity of adverse effects can be increased when Terguride is combined with Lovastatin.Experimental
TerodilineThe metabolism of Terodiline can be decreased when combined with Lovastatin.Experimental
TesmilifeneThe serum concentration of Lovastatin can be increased when it is combined with Tesmilifene.Investigational
TestosteroneThe serum concentration of Lovastatin can be increased when it is combined with Testosterone.Approved, Investigational
Testosterone cypionateThe serum concentration of Lovastatin can be increased when it is combined with Testosterone cypionate.Approved
Testosterone enanthateThe serum concentration of Lovastatin can be increased when it is combined with Testosterone enanthate.Approved
Testosterone propionateThe metabolism of Testosterone propionate can be decreased when combined with Lovastatin.Approved, Investigational, Vet Approved, Withdrawn
Testosterone undecanoateThe serum concentration of Lovastatin can be increased when it is combined with Testosterone undecanoate.Approved, Investigational
TetracyclineThe serum concentration of Tetracycline can be increased when it is combined with Lovastatin.Approved, Vet Approved
TetrahydropalmatineThe metabolism of Tetrahydropalmatine can be decreased when combined with Lovastatin.Investigational
TetrandrineThe serum concentration of Lovastatin can be increased when it is combined with Tetrandrine.Experimental
TezacaftorThe metabolism of Tezacaftor can be decreased when combined with Lovastatin.Approved, Investigational
ThalidomideThe metabolism of Thalidomide can be decreased when combined with Lovastatin.Approved, Investigational, Withdrawn
TheophyllineThe metabolism of Theophylline can be decreased when combined with Lovastatin.Approved
ThiamylalThe metabolism of Thiamylal can be decreased when combined with Lovastatin.Approved, Vet Approved
ThiopentalThe serum concentration of Lovastatin can be increased when it is combined with Thiopental.Approved, Vet Approved
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Lovastatin.Approved, Withdrawn
ThiorphanThe serum concentration of Lovastatin can be increased when it is combined with Thiorphan.Experimental
ThiotepaThe metabolism of Thiotepa can be decreased when combined with Lovastatin.Approved, Investigational
TiagabineThe metabolism of Tiagabine can be decreased when combined with Lovastatin.Approved, Investigational
TicagrelorThe serum concentration of Lovastatin can be increased when it is combined with Ticagrelor.Approved
TiclopidineThe serum concentration of Lovastatin can be increased when it is combined with Ticlopidine.Approved
TildipirosinThe risk or severity of rhabdomyolysis can be increased when Tildipirosin is combined with Lovastatin.Vet Approved
TilmicosinThe risk or severity of rhabdomyolysis can be increased when Tilmicosin is combined with Lovastatin.Investigational, Vet Approved
TinidazoleThe metabolism of Tinidazole can be decreased when combined with Lovastatin.Approved, Investigational
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Lovastatin.Approved
TipranavirThe serum concentration of Lovastatin can be increased when it is combined with Tipranavir.Approved, Investigational
TocilizumabThe serum concentration of Lovastatin can be decreased when it is combined with Tocilizumab.Approved
TocofersolanThe metabolism of Tocofersolan can be decreased when combined with Lovastatin.Approved
TocopherolThe metabolism of Tocopherol can be decreased when combined with Lovastatin.Approved, Investigational
TofacitinibThe metabolism of Tofacitinib can be decreased when combined with Lovastatin.Approved, Investigational
TofisopamThe serum concentration of Lovastatin can be increased when it is combined with Tofisopam.Approved
TolbutamideThe metabolism of Tolbutamide can be decreased when combined with Lovastatin.Approved, Investigational
Tolfenamic AcidThe metabolism of Tolfenamic Acid can be decreased when combined with Lovastatin.Approved, Investigational
TolterodineThe metabolism of Tolterodine can be decreased when combined with Lovastatin.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Lovastatin.Approved
TopiramateThe serum concentration of Topiramate can be increased when it is combined with Lovastatin.Approved
TopiroxostatThe serum concentration of Lovastatin can be increased when it is combined with Topiroxostat.Approved, Investigational
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Lovastatin.Approved, Investigational
TorasemideThe metabolism of Torasemide can be decreased when combined with Lovastatin.Approved
ToremifeneThe metabolism of Toremifene can be decreased when combined with Lovastatin.Approved, Investigational
TrabectedinLovastatin may increase the myopathic rhabdomyolysis activities of Trabectedin.Approved, Investigational
TramadolThe metabolism of Tramadol can be decreased when combined with Lovastatin.Approved, Investigational
TrandolaprilThe serum concentration of Lovastatin can be increased when it is combined with Trandolapril.Approved
TranilastThe metabolism of Tranilast can be decreased when combined with Lovastatin.Approved, Investigational
TranylcypromineThe serum concentration of Lovastatin can be increased when it is combined with Tranylcypromine.Approved, Investigational
Trastuzumab emtansineThe risk or severity of rhabdomyolysis can be increased when Trastuzumab emtansine is combined with Lovastatin.Approved, Investigational
TrazodoneThe metabolism of Trazodone can be decreased when combined with Lovastatin.Approved, Investigational
TreprostinilThe metabolism of Treprostinil can be decreased when combined with Lovastatin.Approved, Investigational
TretinoinThe metabolism of Tretinoin can be decreased when combined with Lovastatin.Approved, Investigational, Nutraceutical
TriamcinoloneThe metabolism of Triamcinolone can be decreased when combined with Lovastatin.Approved, Vet Approved
TriazolamThe metabolism of Triazolam can be decreased when combined with Lovastatin.Approved, Investigational
TrimebutineThe metabolism of Trimebutine can be decreased when combined with Lovastatin.Approved
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Lovastatin.Approved
TrimethoprimThe metabolism of Trimethoprim can be decreased when combined with Lovastatin.Approved, Vet Approved
TrimipramineThe metabolism of Trimipramine can be decreased when combined with Lovastatin.Approved
TroglitazoneThe serum concentration of Lovastatin can be increased when it is combined with Troglitazone.Investigational, Withdrawn
TroleandomycinThe serum concentration of Lovastatin can be increased when it is combined with Troleandomycin.Approved
TromethamineThe serum concentration of Lovastatin can be decreased when it is combined with Tromethamine.Approved
TylosinThe risk or severity of rhabdomyolysis can be increased when Tylosin is combined with Lovastatin.Vet Approved
TylvalosinThe risk or severity of rhabdomyolysis can be increased when Tylvalosin is combined with Lovastatin.Vet Approved
UbenimexThe serum concentration of Lovastatin can be increased when it is combined with Ubenimex.Experimental, Investigational
UbidecarenoneThe serum concentration of Ubidecarenone can be decreased when it is combined with Lovastatin.Approved, Investigational, Nutraceutical
UdenafilThe metabolism of Udenafil can be decreased when combined with Lovastatin.Approved, Investigational
UlinastatinThe serum concentration of Lovastatin can be increased when it is combined with Ulinastatin.Investigational
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Lovastatin.Approved
ValbenazineThe metabolism of Valbenazine can be decreased when combined with Lovastatin.Approved, Investigational
ValdecoxibThe metabolism of Valdecoxib can be decreased when combined with Lovastatin.Approved, Investigational, Withdrawn
Valproic AcidThe metabolism of Valproic Acid can be decreased when combined with Lovastatin.Approved, Investigational
ValsartanThe metabolism of Valsartan can be decreased when combined with Lovastatin.Approved, Investigational
VandetanibThe metabolism of Vandetanib can be decreased when combined with Lovastatin.Approved
VanoxerineThe metabolism of Vanoxerine can be decreased when combined with Lovastatin.Investigational
VardenafilThe metabolism of Vardenafil can be decreased when combined with Lovastatin.Approved
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Lovastatin.Approved
VelpatasvirThe metabolism of Velpatasvir can be decreased when combined with Lovastatin.Approved, Investigational
VemurafenibThe serum concentration of Lovastatin can be decreased when it is combined with Vemurafenib.Approved
VenetoclaxThe metabolism of Venetoclax can be decreased when combined with Lovastatin.Approved, Investigational
VenlafaxineThe serum concentration of Venlafaxine can be increased when it is combined with Lovastatin.Approved
VerapamilThe risk or severity of myopathy and rhabdomyolysis can be increased when Verapamil is combined with Lovastatin.Approved
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Lovastatin.Investigational
VilanterolThe metabolism of Vilanterol can be decreased when combined with Lovastatin.Approved
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Lovastatin.Approved
VildagliptinThe serum concentration of Lovastatin can be increased when it is combined with Vildagliptin.Approved, Investigational
VinblastineThe serum concentration of Lovastatin can be increased when it is combined with Vinblastine.Approved
VincristineThe serum concentration of Lovastatin can be increased when it is combined with Vincristine.Approved, Investigational
VincristineThe excretion of Vincristine can be decreased when combined with Lovastatin.Approved, Investigational
VindesineThe serum concentration of Vindesine can be increased when it is combined with Lovastatin.Approved, Investigational
VinflunineThe metabolism of Vinflunine can be decreased when combined with Lovastatin.Approved, Investigational
VinorelbineThe serum concentration of Lovastatin can be increased when it is combined with Vinorelbine.Approved, Investigational
VinpocetineThe metabolism of Vinpocetine can be decreased when combined with Lovastatin.Investigational
VismodegibThe metabolism of Vismodegib can be decreased when combined with Lovastatin.Approved, Investigational
VoriconazoleThe serum concentration of Lovastatin can be increased when it is combined with Voriconazole.Approved, Investigational
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Lovastatin.Approved, Investigational
VoxilaprevirThe metabolism of Voxilaprevir can be decreased when combined with Lovastatin.Approved, Investigational
WarfarinThe metabolism of Warfarin can be decreased when combined with Lovastatin.Approved
WIN 55212-2The metabolism of WIN 55212-2 can be decreased when combined with Lovastatin.Experimental
XimelagatranThe serum concentration of Lovastatin can be increased when it is combined with Ximelagatran.Approved, Investigational, Withdrawn
YohimbineThe metabolism of Yohimbine can be decreased when combined with Lovastatin.Approved, Investigational, Vet Approved
Z-Val-Ala-Asp fluoromethyl ketoneThe serum concentration of Lovastatin can be increased when it is combined with Z-Val-Ala-Asp fluoromethyl ketone.Experimental
ZafirlukastThe serum concentration of Lovastatin can be increased when it is combined with Zafirlukast.Approved, Investigational
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Lovastatin.Approved, Investigational
ZaleplonThe metabolism of Zaleplon can be decreased when combined with Lovastatin.Approved, Illicit, Investigational
ZaltoprofenThe metabolism of Zaltoprofen can be decreased when combined with Lovastatin.Approved, Investigational
ZiconotideThe metabolism of Ziconotide can be decreased when combined with Lovastatin.Approved
ZidovudineThe serum concentration of Lovastatin can be decreased when it is combined with Zidovudine.Approved
ZileutonThe metabolism of Zileuton can be decreased when combined with Lovastatin.Approved, Investigational, Withdrawn
ZiprasidoneThe serum concentration of Lovastatin can be increased when it is combined with Ziprasidone.Approved
ZofenoprilThe serum concentration of Lovastatin can be increased when it is combined with Zofenopril.Experimental
ZolpidemThe metabolism of Zolpidem can be decreased when combined with Lovastatin.Approved
ZomepiracThe metabolism of Zomepirac can be decreased when combined with Lovastatin.Withdrawn
ZonisamideThe metabolism of Zonisamide can be decreased when combined with Lovastatin.Approved, Investigational
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Lovastatin.Approved
ZotepineThe metabolism of Zotepine can be decreased when combined with Lovastatin.Approved, Investigational, Withdrawn
ZucapsaicinThe serum concentration of Lovastatin can be increased when it is combined with Zucapsaicin.Approved, Investigational
ZuclopenthixolThe serum concentration of Zuclopenthixol can be increased when it is combined with Lovastatin.Approved, Investigational
Food Interactions
  • Avoid alcohol.
  • Avoid drastic changes in dietary habit.
  • Avoid taking with grapefruit juice.
  • Take with food, 50% increase in bioavailability when taken with food.

References

Synthesis Reference

Donald F. Gerson, Xinfa Xiao, "Process for the production of lovastatin using Coniothyrium fuckelii." U.S. Patent US5409820, issued January, 1984.

US5409820
General References
  1. Bobek P, Ozdin L, Galbavy S: Dose- and time-dependent hypocholesterolemic effect of oyster mushroom (Pleurotus ostreatus) in rats. Nutrition. 1998 Mar;14(3):282-6. [PubMed:9583372]
External Links
Human Metabolome Database
HMDB0014372
KEGG Drug
D00359
KEGG Compound
C07074
PubChem Compound
53232
PubChem Substance
46508223
ChemSpider
48085
BindingDB
34168
ChEBI
40303
ChEMBL
CHEMBL503
Therapeutic Targets Database
DAP000551
PharmGKB
PA450272
IUPHAR
2739
Guide to Pharmacology
GtP Drug Page
HET
803
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
Wikipedia
Lovastatin
ATC Codes
C10BA01 — Lovastatin and nicotinic acidC10AA02 — Lovastatin
AHFS Codes
  • 24:06.08 — Hmg-coa Reductase Inhibitors
PDB Entries
1cqp
FDA label
Download (126 KB)
MSDS
Download (99.6 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0CompletedTreatmentLung Inflammation1
1CompletedNot AvailableHealthy Volunteers2
1CompletedBasic ScienceDrug Drug Interactions / Healthy Volunteers1
1CompletedTreatmentLipid Metabolism Disorders1
1CompletedTreatmentNeurofibromatosis 11
1CompletedTreatmentStrokes1
1, 2TerminatedTreatmentAny Cancer / Cancer, Breast1
1, 2TerminatedTreatmentLeukemia Acute Myeloid Leukemia (AML)1
1, 2WithdrawnTreatmentSevere Persistent Asthma1
2Active Not RecruitingTreatmentJaundice / Rhabdomyolysis / Strokes1
2CompletedBasic ScienceBlood Platelets Proteome1
2CompletedPreventionAtherosclerosis / Cardiovascular Disease (CVD) / Coronary Heart Disease (CHD) / Heart Diseases / High Blood Cholesterol Level / Myocardial Ischemia1
2CompletedPreventionCardiovascular Disease (CVD) / Carotid Stenosis / Cerebral Arteriosclerosis / Cerebrovascular Disorders / Heart Diseases / Vascular Diseases1
2CompletedPreventionPrecancerous Conditions / Stage 0 Melanoma / Stage I Melanoma / Stage II Melanoma1
2CompletedSupportive CareProstate Cancer1
2CompletedTreatmentChronic Obstructive Pulmonary Disease (COPD)1
2CompletedTreatmentHIV Seropositivity1
2CompletedTreatmentNeurofibromatosis Type 11
2CompletedTreatmentRett's Syndrome1
2CompletedTreatmentRheumatoid Arthritis1
2Enrolling by InvitationTreatmentFragile X Syndrome (FXS)1
2RecruitingOtherParkinson's Disease (PD)1
2RecruitingTreatmentFragile X Syndrome (FXS)1
2RecruitingTreatmentImpaired Cognition / Impaired Synaptic Plasticity / Noonan Syndrome, Neurofibromatosis Type 11
2RecruitingTreatmentLearning Disability / Neurofibromatosis Type 1 / NF1 / Reading Disability1
2TerminatedSupportive CareCancer, Breast / Radiation Toxicity1
2TerminatedTreatmentCancer of the Ovary1
2TerminatedTreatmentCancer, Breast1
2Unknown StatusTreatmentXanthomatosis, Cerebrotendinous1
2WithdrawnTreatmentChild Syndrome / Conradi Syndrome / Smith Lemli Opitz Syndrome / Syndromic Ichthyoses1
2WithdrawnTreatmentMalignant Melanoma / Melanoma1
2, 3CompletedTreatmentAlveolar Bone Loss, Chronic Periodontitis, Lovestatin Gel, Regeneration1
2, 3CompletedTreatmentAtherosclerosis / Coronary Artery Disease1
3CompletedPreventionCardiovascular Disease (CVD) / Coronary Heart Disease (CHD) / Heart Diseases / Myocardial Ischemia1
3CompletedPreventionHigh Blood Cholesterol Level1
3CompletedTreatmentCardiovascular Disease (CVD) / Coronary Arteriosclerosis / Coronary Heart Disease (CHD) / Heart Diseases / Myocardial Ischemia1
3CompletedTreatmentHigh Blood Cholesterol Level1
3CompletedTreatmentIntermittent Claudication / Peripheral Vascular Disease (PVD)2
3Not Yet RecruitingTreatmentHigh Blood Cholesterol Level1
3RecruitingTreatmentHigh Blood Cholesterol Level1
3TerminatedTreatmentHigh Blood Cholesterol Level1
4CompletedTreatmentDyslipidemias / Hyperlipidemias / Mixed hypercholesterolemia1
4CompletedTreatmentHealthy Volunteers2
4RecruitingTreatmentFragile X Syndrome (FXS) / Genetic Diseases1
Not AvailableCompletedNot AvailableCardiovascular Disease (CVD) / Type 2 Diabetes Mellitus1
Not AvailableCompletedNot AvailableHigh Blood Cholesterol Level1
Not AvailableCompletedBasic ScienceDrug-Drug Interaction (DDI) / Healthy Volunteers1
Not AvailableSuspendedTreatmentProstate Cancer1

Pharmacoeconomics

Manufacturers
  • Andrx labs llc
  • Actavis elizabeth llc
  • Apotex inc
  • Carlsbad technology inc
  • Lupin ltd
  • Mutual pharmaceutical co inc
  • Mylan pharmaceuticals inc
  • Sandoz inc
  • Teva pharmaceuticals usa inc
  • Merck research laboratories div merck co inc
Packagers
  • Actavis Group
  • Advanced Pharmaceutical Services Inc.
  • Amerisource Health Services Corp.
  • Apotex Inc.
  • Apotheca Inc.
  • A-S Medication Solutions LLC
  • Bryant Ranch Prepack
  • Cardinal Health
  • Carlsbad Technology Inc.
  • Comprehensive Consultant Services Inc.
  • DHHS Program Support Center Supply Service Center
  • Dispensing Solutions
  • Diversified Healthcare Services Inc.
  • Eon Labs
  • Heartland Repack Services LLC
  • International Laboratories Inc.
  • Ivax Pharmaceuticals
  • Kaiser Foundation Hospital
  • Lake Erie Medical and Surgical Supply
  • Lupin Pharmaceuticals Inc.
  • Major Pharmaceuticals
  • Mckesson Corp.
  • Medvantx Inc.
  • Merck & Co.
  • Murfreesboro Pharmaceutical Nursing Supply
  • Mutual Pharmaceutical Co.
  • Mylan
  • Neuman Distributors Inc.
  • Nucare Pharmaceuticals Inc.
  • Palmetto Pharmaceuticals Inc.
  • PCA LLC
  • PD-Rx Pharmaceuticals Inc.
  • Pharmaceutical Utilization Management Program VA Inc.
  • Pharmedix
  • Physicians Total Care Inc.
  • Preferred Pharmaceuticals Inc.
  • Prepackage Specialists
  • Prepak Systems Inc.
  • Rebel Distributors Corp.
  • Remedy Repack
  • Resource Optimization and Innovation LLC
  • Sandhills Packaging Inc.
  • Sciele Pharma Inc.
  • Shionogi Pharma Inc.
  • Southwood Pharmaceuticals
  • Teva Pharmaceutical Industries Ltd.
  • UDL Laboratories
  • Va Cmop Dallas
  • Vangard Labs Inc.
  • Watson Pharmaceuticals
  • Yung Shin Pharmaceutical Industry Ltd.
Dosage forms
FormRouteStrength
Tablet, extended releaseOral
Tablet, extended release; tablet, multilayer, extended releaseOral
Tablet, extended releaseOral20 mg/1
Tablet, extended releaseOral40 mg/1
Tablet, extended releaseOral60 mg/1
TabletOral20 mg
TabletOral40 mg
TabletOral10 mg/1
TabletOral20 mg/1
TabletOral40 mg/1
Prices
Unit descriptionCostUnit
Altoprev 60 mg 24 Hour tablet7.99USD tablet
Altoprev 60 mg tablet7.74USD tablet
Altoprev 20 mg 24 Hour tablet6.88USD tablet
Altoprev 20 mg tablet6.61USD tablet
Mevacor 40 mg tablet4.57USD tablet
Altoprev 40 mg tablet4.41USD tablet
Lovastatin 40 mg tablet4.36USD tablet
Altoprev 10 mg 24 Hour tablet3.07USD tablet
Mevacor 20 mg tablet2.53USD tablet
Lovastatin 20 mg tablet2.42USD tablet
Altocor 20 mg 24 Hour tablet2.36USD tablet
Apo-Lovastatin 40 mg Tablet2.11USD tablet
Co Lovastatin 40 mg Tablet2.11USD tablet
Mylan-Lovastatin 40 mg Tablet2.11USD tablet
Novo-Lovastatin 40 mg Tablet2.11USD tablet
Pms-Lovastatin 40 mg Tablet2.11USD tablet
Ran-Lovastatin 40 mg Tablet2.11USD tablet
Ratio-Lovastatin 40 mg Tablet2.11USD tablet
Sandoz Lovastatin 40 mg Tablet2.11USD tablet
Mevacor 10 mg tablet1.65USD tablet
Lovastatin 10 mg tablet1.37USD tablet
Apo-Lovastatin 20 mg Tablet1.14USD tablet
Co Lovastatin 20 mg Tablet1.14USD tablet
Mylan-Lovastatin 20 mg Tablet1.14USD tablet
Novo-Lovastatin 20 mg Tablet1.14USD tablet
Pms-Lovastatin 20 mg Tablet1.14USD tablet
Ran-Lovastatin 20 mg Tablet1.14USD tablet
Ratio-Lovastatin 20 mg Tablet1.14USD tablet
Sandoz Lovastatin 20 mg Tablet1.14USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US6080428No1997-05-272017-05-27Us
US6469035No1998-03-152018-03-15Us
US6080778No1998-03-232018-03-23Us
US6485748No1997-12-122017-12-12Us
US5916595No1997-12-122017-12-12Us

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)174.5 °CNot Available
water solubility0.0004 mg/mLNot Available
logP4.26HANSCH,C ET AL. (1995)
Predicted Properties
PropertyValueSource
Water Solubility0.0243 mg/mLALOGPS
logP4.11ALOGPS
logP3.9ChemAxon
logS-4.2ALOGPS
pKa (Strongest Acidic)14.91ChemAxon
pKa (Strongest Basic)-2.8ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area72.83 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity113.18 m3·mol-1ChemAxon
Polarizability46.11 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9452
Blood Brain Barrier+0.9287
Caco-2 permeable-0.5484
P-glycoprotein substrateSubstrate0.7861
P-glycoprotein inhibitor IInhibitor0.7046
P-glycoprotein inhibitor IIInhibitor0.8388
Renal organic cation transporterNon-inhibitor0.8299
CYP450 2C9 substrateNon-substrate0.8333
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateSubstrate0.6868
CYP450 1A2 substrateNon-inhibitor0.9045
CYP450 2C9 inhibitorNon-inhibitor0.9291
CYP450 2D6 inhibitorNon-inhibitor0.923
CYP450 2C19 inhibitorNon-inhibitor0.9026
CYP450 3A4 inhibitorInhibitor0.796
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8682
Ames testNon AMES toxic0.8475
CarcinogenicityNon-carcinogens0.9519
BiodegradationNot ready biodegradable0.8819
Rat acute toxicity2.0554 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.7272
hERG inhibition (predictor II)Non-inhibitor0.7484
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
GC-MS Spectrum - EI-BGC-MSsplash10-0a4i-2910000000-dc8caf3905a76d1dc259
GC-MS Spectrum - EI-BGC-MSsplash10-0a4j-1910000000-8aeacab386a420581150
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-qTof , PositiveLC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-qTof , PositiveLC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-qTof , PositiveLC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-0k9j-0392200000-046f8ecdd9105ec8f133
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-0fg2-0590000000-79f2e6dc3b230361fea3
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-0092-0970000000-029f3798d63ab95ed321
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-0592-0930000000-85de8f33dd78ba45de36
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-05fv-0910000000-7a730b8fcd91e3df5b8f
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-000e-0590000000-2206c97b74e146b3218d
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-0092-1960000000-6b3a14df210273b89f18
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-0592-1910000000-38bd634327305fe325cf
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-0abd-1900000000-e7dab133ffe03d435831
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-0536-2900000000-12e639483c7d1a83da05
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-002f-2900000000-ed64daa9de830f1f3cb0

Taxonomy

Description
This compound belongs to the class of organic compounds known as delta valerolactones. These are cyclic organic compounds containing an oxan-2- one moiety.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Lactones
Sub Class
Delta valerolactones
Direct Parent
Delta valerolactones
Alternative Parents
Fatty acid esters / Oxanes / Dicarboxylic acids and derivatives / Secondary alcohols / Carboxylic acid esters / Oxacyclic compounds / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds
Substituents
Delta valerolactone / Fatty acid ester / Delta_valerolactone / Dicarboxylic acid or derivatives / Oxane / Fatty acyl / Carboxylic acid ester / Secondary alcohol / Carboxylic acid derivative / Oxacycle
Molecular Framework
Aliphatic heteropolycyclic compounds
External Descriptors
polyketide, fatty acid ester, delta-lactone, carbobicyclic compound, statin (naturally occurring) (CHEBI:40303)

Targets

Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Inhibitor
General Function
Nadph binding
Specific Function
Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including...
Gene Name
HMGCR
Uniprot ID
P04035
Uniprot Name
3-hydroxy-3-methylglutaryl-coenzyme A reductase
Molecular Weight
97475.155 Da
References
  1. Abe Y, Suzuki T, Ono C, Iwamoto K, Hosobuchi M, Yoshikawa H: Molecular cloning and characterization of an ML-236B (compactin) biosynthetic gene cluster in Penicillium citrinum. Mol Genet Genomics. 2002 Jul;267(5):636-46. Epub 2002 Jun 28. [PubMed:12172803]
  2. Miyazaki A, Koieyama T, Shimada Y, Kikuchi T, Nezu H, Ito K, Kasanuki N, Koga T: Effects of pravastatin sodium on mevalonate metabolism in common marmosets. J Biochem. 2002 Sep;132(3):395-400. [PubMed:12204108]
  3. Buxbaum JD, Geoghagen NS, Friedhoff LT: Cholesterol depletion with physiological concentrations of a statin decreases the formation of the Alzheimer amyloid Abeta peptide. J Alzheimers Dis. 2001 Apr;3(2):221-229. [PubMed:12214063]
  4. Baranova NA, Kreier VG, Egorov NS: [Concentration on Diapak C 16 capsules of lovastatin, mevinolinic acid and other inhibitors of biosynthesis of sterins produced by Penicillium citrinum 89]. Antibiot Khimioter. 2002;47(4):3-6. [PubMed:12369143]
  5. Farina HG, Bublik DR, Alonso DF, Gomez DE: Lovastatin alters cytoskeleton organization and inhibits experimental metastasis of mammary carcinoma cells. Clin Exp Metastasis. 2002;19(6):551-9. [PubMed:12405293]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352]
  7. Podar K, Tai YT, Hideshima T, Vallet S, Richardson PG, Anderson KC: Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127. doi: 10.1517/14728210802676278 . [PubMed:19249983]
  8. Dimitroulakos J, Marhin WH, Tokunaga J, Irish J, Gullane P, Penn LZ, Kamel-Reid S: Microarray and biochemical analysis of lovastatin-induced apoptosis of squamous cell carcinomas. Neoplasia. 2002 Jul-Aug;4(4):337-46. [PubMed:12082550]
Details
2. Integrin alpha-L
Kind
Protein
Organism
Human
Pharmacological action
No
Actions
Other/unknown
General Function
Metal ion binding
Specific Function
Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated ...
Gene Name
ITGAL
Uniprot ID
P20701
Uniprot Name
Integrin alpha-L
Molecular Weight
128768.495 Da
References
  1. Kallen J, Welzenbach K, Ramage P, Geyl D, Kriwacki R, Legge G, Cottens S, Weitz-Schmidt G, Hommel U: Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain. J Mol Biol. 1999 Sep 10;292(1):1-9. [PubMed:10493852]
Details
3. Histone deacetylase 2
Kind
Protein
Organism
Human
Pharmacological action
No
Actions
Other
General Function
Transcription factor binding
Specific Function
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an impo...
Gene Name
HDAC2
Uniprot ID
Q92769
Uniprot Name
Histone deacetylase 2
Molecular Weight
55363.855 Da
References
  1. Lin YC, Lin JH, Chou CW, Chang YF, Yeh SH, Chen CC: Statins increase p21 through inhibition of histone deacetylase activity and release of promoter-associated HDAC1/2. Cancer Res. 2008 Apr 1;68(7):2375-83. doi: 10.1158/0008-5472.CAN-07-5807. [PubMed:18381445]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
Inhibitor
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Rendic S: Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. [PubMed:11996015]
  2. Hong SP, Yang JS, Han JY, Ha SI, Chung JW, Koh YY, Chang KS, Choi DH: Effects of lovastatin on the pharmacokinetics of diltiazem and its main metabolite, desacetyldiltiazem, in rats: possible role of cytochrome P450 3A4 and P-glycoprotein inhibition by lovastatin. J Pharm Pharmacol. 2011 Jan;63(1):129-35. [PubMed:21189658]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
  4. TABLETS MEVACOR® (LOVASTATIN) FDA LABEL [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Oxygen binding
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP3A5
Uniprot ID
P20815
Uniprot Name
Cytochrome P450 3A5
Molecular Weight
57108.065 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014]
  2. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Oxygen binding
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP3A7
Uniprot ID
P24462
Uniprot Name
Cytochrome P450 3A7
Molecular Weight
57525.03 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Protein homodimerization activity
Specific Function
Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- ...
Gene Name
PON3
Uniprot ID
Q15166
Uniprot Name
Serum paraoxonase/lactonase 3
Molecular Weight
39607.185 Da
References
  1. Draganov DI, Stetson PL, Watson CE, Billecke SS, La Du BN: Rabbit serum paraoxonase 3 (PON3) is a high density lipoprotein-associated lactonase and protects low density lipoprotein against oxidation. J Biol Chem. 2000 Oct 27;275(43):33435-42. [PubMed:10931838]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2C8
Uniprot ID
P10632
Uniprot Name
Cytochrome P450 2C8
Molecular Weight
55824.275 Da
References
  1. Tornio A, Pasanen MK, Laitila J, Neuvonen PJ, Backman JT: Comparison of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) as inhibitors of cytochrome P450 2C8. Basic Clin Pharmacol Toxicol. 2005 Aug;97(2):104-8. [PubMed:15998357]
  2. Walsky RL, Gaman EA, Obach RS: Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol. 2005 Jan;45(1):68-78. [PubMed:15601807]
  3. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
Inducer
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2C9
Uniprot ID
P11712
Uniprot Name
Cytochrome P450 2C9
Molecular Weight
55627.365 Da
References
  1. Cohen LH, van Leeuwen RE, van Thiel GC, van Pelt JF, Yap SH: Equally potent inhibitors of cholesterol synthesis in human hepatocytes have distinguishable effects on different cytochrome P450 enzymes. Biopharm Drug Dispos. 2000 Dec;21(9):353-64. [PubMed:11523064]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Steroid hydroxylase activity
Specific Function
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and im...
Gene Name
CYP2C19
Uniprot ID
P33261
Uniprot Name
Cytochrome P450 2C19
Molecular Weight
55930.545 Da
References
  1. Cohen LH, van Leeuwen RE, van Thiel GC, van Pelt JF, Yap SH: Equally potent inhibitors of cholesterol synthesis in human hepatocytes have distinguishable effects on different cytochrome P450 enzymes. Biopharm Drug Dispos. 2000 Dec;21(9):353-64. [PubMed:11523064]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Steroid hydroxylase activity
Specific Function
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic...
Gene Name
CYP2D6
Uniprot ID
P10635
Uniprot Name
Cytochrome P450 2D6
Molecular Weight
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Steroid binding
Specific Function
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the...
Gene Name
UGT1A1
Uniprot ID
P22309
Uniprot Name
UDP-glucuronosyltransferase 1-1
Molecular Weight
59590.91 Da
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Retinoic acid binding
Specific Function
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative reg...
Gene Name
UGT1A3
Uniprot ID
P35503
Uniprot Name
UDP-glucuronosyltransferase 1-3
Molecular Weight
60337.835 Da
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Glucuronosyltransferase activity
Specific Function
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.Its unique specificity for 3,4-catechol estrogens and estriol su...
Gene Name
UGT2B7
Uniprot ID
P16662
Uniprot Name
UDP-glucuronosyltransferase 2B7
Molecular Weight
60694.12 Da
References
  1. Prueksaritanont T, Subramanian R, Fang X, Ma B, Qiu Y, Lin JH, Pearson PG, Baillie TA: Glucuronidation of statins in animals and humans: a novel mechanism of statin lactonization. Drug Metab Dispos. 2002 May;30(5):505-12. [PubMed:11950779]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Xenobiotic-transporting atpase activity
Specific Function
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name
ABCB1
Uniprot ID
P08183
Uniprot Name
Multidrug resistance protein 1
Molecular Weight
141477.255 Da
References
  1. Wang E, Casciano CN, Clement RP, Johnson WW: HMG-CoA reductase inhibitors (statins) characterized as direct inhibitors of P-glycoprotein. Pharm Res. 2001 Jun;18(6):800-6. [PubMed:11474784]
  2. Wang EJ, Casciano CN, Clement RP, Johnson WW: Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors. Biochem Biophys Res Commun. 2001 Nov 30;289(2):580-5. [PubMed:11716514]
  3. Kim RB, Wandel C, Leake B, Cvetkovic M, Fromm MF, Dempsey PJ, Roden MM, Belas F, Chaudhary AK, Roden DM, Wood AJ, Wilkinson GR: Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein. Pharm Res. 1999 Mar;16(3):408-14. [PubMed:10213372]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Sodium-independent organic anion transmembrane transporter activity
Specific Function
Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibit...
Gene Name
SLCO1A2
Uniprot ID
P46721
Uniprot Name
Solute carrier organic anion transporter family member 1A2
Molecular Weight
74144.105 Da
References
  1. Cvetkovic M, Leake B, Fromm MF, Wilkinson GR, Kim RB: OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab Dispos. 1999 Aug;27(8):866-71. [PubMed:10421612]
  2. Hsiang B, Zhu Y, Wang Z, Wu Y, Sasseville V, Yang WP, Kirchgessner TG: A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters. J Biol Chem. 1999 Dec 24;274(52):37161-8. [PubMed:10601278]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
Inhibitor
General Function
Sodium-independent organic anion transmembrane transporter activity
Specific Function
Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostagland...
Gene Name
SLCO1B1
Uniprot ID
Q9Y6L6
Uniprot Name
Solute carrier organic anion transporter family member 1B1
Molecular Weight
76447.99 Da
References
  1. Hsiang B, Zhu Y, Wang Z, Wu Y, Sasseville V, Yang WP, Kirchgessner TG: A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters. J Biol Chem. 1999 Dec 24;274(52):37161-8. [PubMed:10601278]
  2. Sandhu P, Lee W, Xu X, Leake BF, Yamazaki M, Stone JA, Lin JH, Pearson PG, Kim RB: Hepatic uptake of the novel antifungal agent caspofungin. Drug Metab Dispos. 2005 May;33(5):676-82. Epub 2005 Feb 16. [PubMed:15716364]
  3. Kunze A, Huwyler J, Camenisch G, Poller B: Prediction of organic anion-transporting polypeptide 1B1- and 1B3-mediated hepatic uptake of statins based on transporter protein expression and activity data. Drug Metab Dispos. 2014 Sep;42(9):1514-21. doi: 10.1124/dmd.114.058412. Epub 2014 Jul 2. [PubMed:24989890]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Organic anion transmembrane transporter activity
Specific Function
Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.
Gene Name
ABCC2
Uniprot ID
Q92887
Uniprot Name
Canalicular multispecific organic anion transporter 1
Molecular Weight
174205.64 Da
References
  1. Ellis LC, Hawksworth GM, Weaver RJ: ATP-dependent transport of statins by human and rat MRP2/Mrp2. Toxicol Appl Pharmacol. 2013 Jun 1;269(2):187-94. doi: 10.1016/j.taap.2013.03.019. Epub 2013 Apr 2. [PubMed:23562342]
Kind
Protein
Organism
Human
Pharmacological action
No
Actions
Substrate
General Function
Transporter activity
Specific Function
Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.
Gene Name
ABCB11
Uniprot ID
O95342
Uniprot Name
Bile salt export pump
Molecular Weight
146405.83 Da
References
  1. Pedersen JM, Matsson P, Bergstrom CA, Hoogstraate J, Noren A, LeCluyse EL, Artursson P: Early identification of clinically relevant drug interactions with the human bile salt export pump (BSEP/ABCB11). Toxicol Sci. 2013 Dec;136(2):328-43. doi: 10.1093/toxsci/kft197. Epub 2013 Sep 6. [PubMed:24014644]

Drug created on June 13, 2005 07:24 / Updated on August 15, 2018 09:37