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Identification
NameMevastatin
Accession NumberDB06693
TypeSmall Molecule
GroupsExperimental
DescriptionMevastatin or compactin is a cholesterol-lowering agent isolated from Penicillium citinium. It was the first discovered agent belonging to the class of cholesterol-lowering medications known as statins. During a search for antibiotic compounds produced by fungi in 1971, Akira Endo at Sankyo Co. (Japan) discovered a class of compounds that appeared to lower plasma cholesterol levels. Two years later, the research group isolated a compound structurally similar to hydroxymethylglutarate (HMG) that inhibited the incorporation of acetate. The compound was proposed to bind to the reductase enzyme and was named compactin. Mevastatin is a competitive inhibitor of HMG-Coenzyme A (HMG-CoA) reductase with a binding affinity 10,000 times greater than the HMG-CoA substrate itself. Mevastatin is a pro-drug that is activated by in vivo hydrolysis of the lactone ring. It has served as one of the lead compounds for the development of the synthetic compounds used today.
Structure
Thumb
Synonyms
Compactin
External Identifiers Not Available
Approved Prescription ProductsNot Available
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
SaltsNot Available
Categories
UNII1UQM1K0W9X
CAS number73573-88-3
WeightAverage: 390.52
Monoisotopic: 390.240624195
Chemical FormulaC23H34O5
InChI KeyAJLFOPYRIVGYMJ-INTXDZFKSA-N
InChI
InChI=1S/C23H34O5/c1-4-14(2)23(26)28-20-7-5-6-16-9-8-15(3)19(22(16)20)11-10-18-12-17(24)13-21(25)27-18/h6,8-9,14-15,17-20,22,24H,4-5,7,10-13H2,1-3H3/t14-,15-,17+,18+,19-,20-,22-/m0/s1
IUPAC Name
(1S,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate
SMILES
[H][C@]12[[email protected]](CCC=C1C=C[[email protected]](C)[C@@H]2CC[C@@H]1C[C@@H](O)CC(=O)O1)OC(=O)[C@@H](C)CC
Pharmacology
IndicationNot used therapeutically due to its many side effects.
Structured Indications Not Available
PharmacodynamicsThe primary cause of cardiovascular disease is atherosclerotic plaque formation. Sustained elevations of cholesterol in the blood increase the risk of cardiovascular disease. Mevastatin lowers hepatic production of cholesterol by competitively inhibiting HMG-CoA reductase, the enzyme that catalyzes the rate-limiting step in the cholesterol biosynthesis pathway via the mevalonic acid pathway. Decreased hepatic cholesterol levels causes increased uptake of low density lipoprotein (LDL) cholesterol and reduces cholesterol levels in the circulation.
Mechanism of actionMevastatin is structurally similar to the HMG, a substituent of the endogenous substrate of HMG-CoA reductase. Mevastatin is a prodrug that is activated in vivo via hydrolysis of the lactone ring. The hydrolyzed lactone ring mimics the tetrahedral intermediate produced by the reductase allowing the agent to bind with 10,000 times greater affinity than its natural substrate. The bicyclic portion of mevastatin binds to the coenzyme A portion of the active site.
TargetKindPharmacological actionActionsOrganismUniProt ID
3-hydroxy-3-methylglutaryl-coenzyme A reductaseProteinyes
inhibitor
HumanP04035 details
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicitySide effects include those of other statins, such as myalgias, abdominal pain, nausea. It also has a higher chance of giving more severe side effects related to myotoxicity (myopathy, myositis, rhabdomyolysis), and hepatotoxicity, than other statins. Due to these major side effects and their enhanced rate of occurance, Mevastatin is not given therapeutically.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
AcenocoumarolMevastatin may increase the anticoagulant activities of Acenocoumarol.Approved
AcipimoxAcipimox may increase the myopathic rhabdomyolysis activities of Mevastatin.Approved
Aluminum hydroxideThe serum concentration of Mevastatin can be decreased when it is combined with Aluminum hydroxide.Approved
Aluminum phosphateThe serum concentration of Mevastatin can be decreased when it is combined with Aluminum phosphate.Approved
AmiodaroneThe metabolism of Mevastatin can be decreased when combined with Amiodarone.Approved, Investigational
AmlodipineThe risk or severity of adverse effects can be increased when Mevastatin is combined with Amlodipine.Approved
Amphotericin BThe therapeutic efficacy of Amphotericin B can be decreased when used in combination with Mevastatin.Approved, Investigational
AmrinoneThe risk or severity of adverse effects can be increased when Mevastatin is combined with Amrinone.Approved
AzelnidipineThe risk or severity of adverse effects can be increased when Mevastatin is combined with Azelnidipine.Approved
AzimilideThe risk or severity of adverse effects can be increased when Mevastatin is combined with Azimilide.Investigational
BarnidipineThe risk or severity of adverse effects can be increased when Mevastatin is combined with Barnidipine.Approved
BcgThe therapeutic efficacy of Bcg can be decreased when used in combination with Mevastatin.Investigational
BenidipineThe risk or severity of adverse effects can be increased when Mevastatin is combined with Benidipine.Approved
BepridilThe risk or severity of adverse effects can be increased when Mevastatin is combined with Bepridil.Approved, Withdrawn
BezafibrateBezafibrate may increase the myopathic rhabdomyolysis activities of Mevastatin.Approved
Bismuth SubcitrateThe serum concentration of Mevastatin can be decreased when it is combined with Bismuth Subcitrate.Approved
BosentanThe metabolism of Mevastatin can be increased when combined with Bosentan.Approved, Investigational
BuspironeThe metabolism of Buspirone can be decreased when combined with Mevastatin.Approved, Investigational
BusulfanThe serum concentration of Busulfan can be increased when it is combined with Mevastatin.Approved, Investigational
CaiThe risk or severity of adverse effects can be increased when Mevastatin is combined with Cai.Investigational
Calcium carbonateThe serum concentration of Mevastatin can be decreased when it is combined with Calcium carbonate.Approved
CilnidipineThe risk or severity of adverse effects can be increased when Mevastatin is combined with Cilnidipine.Approved
CinnarizineThe risk or severity of adverse effects can be increased when Mevastatin is combined with Cinnarizine.Approved
CiprofibrateThe risk or severity of adverse effects can be increased when Ciprofibrate is combined with Mevastatin.Approved
CisaprideThe serum concentration of Cisapride can be increased when it is combined with Mevastatin.Approved, Investigational, Withdrawn
ClevidipineThe risk or severity of adverse effects can be increased when Mevastatin is combined with Clevidipine.Approved
ColchicineColchicine may increase the myopathic rhabdomyolysis activities of Mevastatin.Approved
ConivaptanThe metabolism of Conivaptan can be decreased when combined with Mevastatin.Approved, Investigational
CyclosporineThe metabolism of Cyclosporine can be decreased when combined with Mevastatin.Approved, Investigational, Vet Approved
Cyproterone acetateThe serum concentration of Mevastatin can be increased when it is combined with Cyproterone acetate.Approved, Investigational
DaclatasvirThe serum concentration of Mevastatin can be increased when it is combined with Daclatasvir.Approved
DanazolThe serum concentration of Mevastatin can be increased when it is combined with Danazol.Approved
DaptomycinThe risk or severity of adverse effects can be increased when Mevastatin is combined with Daptomycin.Approved, Investigational
DarodipineThe risk or severity of adverse effects can be increased when Mevastatin is combined with Darodipine.Experimental
DicoumarolMevastatin may increase the anticoagulant activities of Dicoumarol.Approved
DidanosineDidanosine can cause a decrease in the absorption of Mevastatin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
DiltiazemThe risk or severity of adverse effects can be increased when Mevastatin is combined with Diltiazem.Approved
DocetaxelThe metabolism of Docetaxel can be decreased when combined with Mevastatin.Approved, Investigational
DofetilideThe metabolism of Dofetilide can be decreased when combined with Mevastatin.Approved
DotarizineThe risk or severity of adverse effects can be increased when Mevastatin is combined with Dotarizine.Investigational
EfonidipineThe risk or severity of adverse effects can be increased when Mevastatin is combined with Efonidipine.Approved
EperisoneThe risk or severity of adverse effects can be increased when Mevastatin is combined with Eperisone.Approved, Investigational
Ethyl biscoumacetateMevastatin may increase the anticoagulant activities of Ethyl biscoumacetate.Withdrawn
EtravirineThe serum concentration of Etravirine can be increased when it is combined with Mevastatin.Approved
FelodipineThe risk or severity of adverse effects can be increased when Mevastatin is combined with Felodipine.Approved, Investigational
FendilineThe risk or severity of adverse effects can be increased when Mevastatin is combined with Fendiline.Withdrawn
FenofibrateThe risk or severity of adverse effects can be increased when Fenofibrate is combined with Mevastatin.Approved
FluindioneMevastatin may increase the anticoagulant activities of Fluindione.Investigational
FlunarizineThe risk or severity of adverse effects can be increased when Mevastatin is combined with Flunarizine.Approved
FosphenytoinThe serum concentration of Mevastatin can be decreased when it is combined with Fosphenytoin.Approved
Fusidic AcidThe risk or severity of adverse effects can be increased when Fusidic Acid is combined with Mevastatin.Approved
GabapentinThe risk or severity of adverse effects can be increased when Mevastatin is combined with Gabapentin.Approved, Investigational
GallopamilThe risk or severity of adverse effects can be increased when Mevastatin is combined with Gallopamil.Investigational
IsradipineThe risk or severity of adverse effects can be increased when Mevastatin is combined with Isradipine.Approved
LacidipineThe risk or severity of adverse effects can be increased when Mevastatin is combined with Lacidipine.Approved
LamotrigineThe risk or severity of adverse effects can be increased when Mevastatin is combined with Lamotrigine.Approved, Investigational
Lanthanum carbonateThe serum concentration of Lanthanum carbonate can be decreased when it is combined with Mevastatin.Approved
LercanidipineThe risk or severity of adverse effects can be increased when Mevastatin is combined with Lercanidipine.Approved, Investigational
LosartanThe metabolism of Losartan can be decreased when combined with Mevastatin.Approved
MagaldrateThe serum concentration of Mevastatin can be decreased when it is combined with Magaldrate.Withdrawn
Magnesium carbonateThe serum concentration of Mevastatin can be decreased when it is combined with Magnesium carbonate.Approved
Magnesium hydroxideThe serum concentration of Mevastatin can be decreased when it is combined with Magnesium hydroxide.Approved
Magnesium oxideThe serum concentration of Mevastatin can be decreased when it is combined with Magnesium oxide.Approved
Magnesium SulfateThe risk or severity of adverse effects can be increased when Mevastatin is combined with Magnesium Sulfate.Approved, Vet Approved
Magnesium TrisilicateThe serum concentration of Mevastatin can be decreased when it is combined with Magnesium Trisilicate.Approved
ManidipineThe risk or severity of adverse effects can be increased when Mevastatin is combined with Manidipine.Approved
MibefradilThe risk or severity of adverse effects can be increased when Mevastatin is combined with Mibefradil.Withdrawn
NaftopidilThe risk or severity of adverse effects can be increased when Mevastatin is combined with Naftopidil.Investigational
NiacinThe risk or severity of adverse effects can be increased when Niacin is combined with Mevastatin.Approved, Investigational, Nutraceutical
NicardipineThe risk or severity of adverse effects can be increased when Mevastatin is combined with Nicardipine.Approved
NicotinamideThe risk or severity of adverse effects can be increased when Nicotinamide is combined with Mevastatin.Approved
NifedipineThe risk or severity of adverse effects can be increased when Mevastatin is combined with Nifedipine.Approved
NiguldipineThe risk or severity of adverse effects can be increased when Mevastatin is combined with Niguldipine.Experimental
NiludipineThe risk or severity of adverse effects can be increased when Mevastatin is combined with Niludipine.Experimental
NilvadipineThe risk or severity of adverse effects can be increased when Mevastatin is combined with Nilvadipine.Approved
NimesulideThe risk or severity of adverse effects can be increased when Mevastatin is combined with Nimesulide.Approved, Withdrawn
NimodipineThe risk or severity of adverse effects can be increased when Mevastatin is combined with Nimodipine.Approved
NisoldipineThe risk or severity of adverse effects can be increased when Mevastatin is combined with Nisoldipine.Approved
NitrendipineThe risk or severity of adverse effects can be increased when Mevastatin is combined with Nitrendipine.Approved
PazopanibMevastatin may increase the hepatotoxic activities of Pazopanib.Approved
PerhexilineThe risk or severity of adverse effects can be increased when Mevastatin is combined with Perhexiline.Approved
PhenindioneMevastatin may increase the anticoagulant activities of Phenindione.Approved
PhenprocoumonMevastatin may increase the anticoagulant activities of Phenprocoumon.Approved
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Mevastatin.Approved, Vet Approved
Picosulfuric acidThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Mevastatin.Approved
PimozideMevastatin may increase the arrhythmogenic activities of Pimozide.Approved
PinaveriumThe risk or severity of adverse effects can be increased when Mevastatin is combined with Pinaverium.Approved
PregabalinThe risk or severity of adverse effects can be increased when Mevastatin is combined with Pregabalin.Approved, Illicit, Investigational
PrenylamineThe risk or severity of adverse effects can be increased when Mevastatin is combined with Prenylamine.Withdrawn
ProgesteroneThe therapeutic efficacy of Progesterone can be decreased when used in combination with Mevastatin.Approved, Vet Approved
QuinidineThe metabolism of Quinidine can be decreased when combined with Mevastatin.Approved
QuinineThe serum concentration of Mevastatin can be increased when it is combined with Quinine.Approved
RaltegravirRaltegravir may increase the myopathic rhabdomyolysis activities of Mevastatin.Approved
RanolazineThe metabolism of Ranolazine can be decreased when combined with Mevastatin.Approved, Investigational
RifabutinThe serum concentration of Mevastatin can be decreased when it is combined with Rifabutin.Approved
RifampicinThe serum concentration of Mevastatin can be decreased when it is combined with Rifampicin.Approved
RifapentineThe serum concentration of Mevastatin can be decreased when it is combined with Rifapentine.Approved
RisedronateThe risk or severity of adverse effects can be increased when Mevastatin is combined with Risedronate.Approved, Investigational
SolifenacinThe metabolism of Solifenacin can be decreased when combined with Mevastatin.Approved
St. John's WortThe metabolism of Mevastatin can be increased when combined with St. John's Wort.Nutraceutical
SucralfateSucralfate can cause a decrease in the absorption of Mevastatin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
SunitinibThe metabolism of Sunitinib can be decreased when combined with Mevastatin.Approved, Investigational
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Mevastatin.Approved, Investigational
Tolfenamic AcidThe risk or severity of adverse effects can be increased when Mevastatin is combined with Tolfenamic Acid.Approved
TrabectedinMevastatin may increase the myopathic rhabdomyolysis activities of Trabectedin.Approved, Investigational
TranilastThe risk or severity of adverse effects can be increased when Mevastatin is combined with Tranilast.Approved, Investigational
VerapamilThe risk or severity of adverse effects can be increased when Mevastatin is combined with Verapamil.Approved
VinpocetineThe risk or severity of adverse effects can be increased when Mevastatin is combined with Vinpocetine.Investigational
WarfarinMevastatin may increase the anticoagulant activities of Warfarin.Approved
XylometazolineThe risk or severity of adverse effects can be increased when Mevastatin is combined with Xylometazoline.Approved
ZiconotideThe risk or severity of adverse effects can be increased when Mevastatin is combined with Ziconotide.Approved
ZolpidemThe serum concentration of Zolpidem can be increased when it is combined with Mevastatin.Approved
Food Interactions
  • avoid alcohol
  • Grape fruit juice increases blood levels of the drug
References
Synthesis Reference

Scott Primrose, David King, Ed Yaworski, Jayaramaiyer Radhakrishnan, David He, Xinfa Xiao, “Fermentation process for preparation of compactin.” U.S. Patent US5691173, issued September, 1977.

US5691173
General References
  1. Chemspider [Link]
  2. Pubchem [Link]
External Links
ATC CodesNot Available
AHFS Codes
  • 24:06.08
PDB EntriesNot Available
FDA labelNot Available
MSDSNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9714
Blood Brain Barrier+0.639
Caco-2 permeable-0.6631
P-glycoprotein substrateSubstrate0.7964
P-glycoprotein inhibitor INon-inhibitor0.8324
P-glycoprotein inhibitor IIInhibitor0.6601
Renal organic cation transporterNon-inhibitor0.8617
CYP450 2C9 substrateNon-substrate0.8503
CYP450 2D6 substrateNon-substrate0.9115
CYP450 3A4 substrateSubstrate0.7206
CYP450 1A2 substrateNon-inhibitor0.8952
CYP450 2C9 inhibitorNon-inhibitor0.8909
CYP450 2D6 inhibitorNon-inhibitor0.8903
CYP450 2C19 inhibitorNon-inhibitor0.8513
CYP450 3A4 inhibitorInhibitor0.6571
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.7992
Ames testNon AMES toxic0.8927
CarcinogenicityNon-carcinogens0.9523
BiodegradationNot ready biodegradable0.8854
Rat acute toxicity2.6058 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8359
hERG inhibition (predictor II)Non-inhibitor0.6699
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage formsNot Available
PricesNot Available
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point152 °CPhysProp
logP3.95SANGSTER (1994)
Predicted Properties
PropertyValueSource
Water Solubility0.0321 mg/mLALOGPS
logP4.13ALOGPS
logP3.62ChemAxon
logS-4.1ALOGPS
pKa (Strongest Acidic)14.91ChemAxon
pKa (Strongest Basic)-2.8ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area72.83 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity108.63 m3·mol-1ChemAxon
Polarizability43.57 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as delta valerolactones. These are cyclic organic compounds containing an oxan-2- one moiety.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassLactones
Sub ClassDelta valerolactones
Direct ParentDelta valerolactones
Alternative Parents
Substituents
  • Delta valerolactone
  • Fatty acid ester
  • Delta_valerolactone
  • Dicarboxylic acid or derivatives
  • Oxane
  • Fatty acyl
  • Carboxylic acid ester
  • Secondary alcohol
  • Carboxylic acid derivative
  • Oxacycle
  • Organooxygen compound
  • Hydrocarbon derivative
  • Organic oxide
  • Alcohol
  • Organic oxygen compound
  • Carbonyl group
  • Aliphatic heteropolycyclic compound
Molecular FrameworkAliphatic heteropolycyclic compounds
External Descriptors

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Nadph binding
Specific Function:
Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.
Gene Name:
HMGCR
Uniprot ID:
P04035
Molecular Weight:
97475.155 Da
References
  1. Kocarek TA, Dahn MS, Cai H, Strom SC, Mercer-Haines NA: Regulation of CYP2B6 and CYP3A expression by hydroxymethylglutaryl coenzyme A inhibitors in primary cultured human hepatocytes. Drug Metab Dispos. 2002 Dec;30(12):1400-5. [PubMed:12433810 ]
  2. Cenedella RJ, Kuszak JR, Al-Ghoul KJ, Qin S, Sexton PS: Discordant expression of the sterol pathway in lens underlies simvastatin-induced cataracts in Chbb: Thom rats. J Lipid Res. 2003 Jan;44(1):198-211. [PubMed:12518039 ]
  3. Stoebner PE, Michot C, Ligeron C, Durand L, Meynadier J, Meunier L: [Simvastatin-induced lichen planus pemphigoides]. Ann Dermatol Venereol. 2003 Feb;130(2 Pt 1):187-90. [PubMed:12671581 ]
  4. Pappu AS, Bacon SP, Illingworth DR: Residual effects of lovastatin and simvastatin on urinary mevalonate excretions in patients with familial hypercholesterolemia. J Lab Clin Med. 2003 Apr;141(4):250-6. [PubMed:12677170 ]
  5. Liu L, Zhang R, Zhao JJ, Rogers JD, Hsieh JY, Fang W, Matuszewski BK, Dobrinska MR: Determination of simvastatin-derived HMG-CoA reductase inhibitors in biomatrices using an automated enzyme inhibition assay with radioactivity detection. J Pharm Biomed Anal. 2003 Apr 24;32(1):107-23. [PubMed:12852453 ]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  7. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Triglyceride lipase activity
Specific Function:
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine. Catalyzes the transesterification of cocaine to form cocaethylene. Displays fatty acid ethyl ester synthase activity,...
Gene Name:
CES1
Uniprot ID:
P23141
Molecular Weight:
62520.62 Da
References
  1. Fleming CD, Bencharit S, Edwards CC, Hyatt JL, Tsurkan L, Bai F, Fraga C, Morton CL, Howard-Williams EL, Potter PM, Redinbo MR: Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil. J Mol Biol. 2005 Sep 9;352(1):165-77. [PubMed:16081098 ]
Comments
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Drug created on March 13, 2010 15:07 / Updated on August 17, 2016 12:24