GABA Agonists

Name
GABA Agonists
Accession Number
DBCAT000427
Description

Endogenous compounds and drugs that bind to and activate GAMMA-AMINOBUTYRIC ACID receptors (RECEPTORS, GABA).

Drugs
DrugDrug Description
BaclofenA GABA-ergic agonist used to manage severe spasticity of cerebral or spinal origin in adult and pediatric patients.
ZolpidemA sedative hypnotic used for the short-term treatment of insomnia to improve sleep latency.
ProgabideIndicated for the treatment of epilepsy.
AZD 3355Investigated for use/treatment in gastroesophageal reflux disease (GERD).
TramiprosateInvestigated for use/treatment in strokes and alzheimer's disease.
GaboxadolInvestigated for use/treatment in sleep disorders and insomnia.
AdipiplonInvestigated for use/treatment in insomnia and sleep disorders.
Arbaclofen PlacarbilInvestigated for the treatment of spasticity in multiple sclerosis, acute back spasms, and GERD.
LesogaberanLesogaberan has been used in trials studying the treatment and basic science of GERD, Reflux, Heartburn, Regurgitation, and Reflux Disease, among others.
MuscimolMuscimol has been used in trials studying the treatment of Epilepsy and Parkinson's Disease.
PhenibutNot Annotated
ZaleplonA sedative used for short term treatment of insomnia in adults.
ClobazamA benzodiazepine used as adjunct treatment in seizures associated with Lennox-Gastaut syndrome.
Drugs & Drug Targets
DrugTargetType
BaclofenGamma-aminobutyric acid type B receptor subunit 1target
BaclofenGamma-aminobutyric acid type B receptor subunit 2target
ZolpidemGamma-aminobutyric acid receptor subunit alpha-1target
ZolpidemCytochrome P450 3A4enzyme
ZolpidemCytochrome P450 1A2enzyme
ZolpidemGamma-aminobutyric acid receptor subunit alpha-2target
ZolpidemGamma-aminobutyric acid receptor subunit alpha-3target
ZolpidemCytochrome P450 2C9enzyme
ZolpidemCytochrome P450 2C19enzyme
ZolpidemCytochrome P450 2D6enzyme
ZolpidemGamma-aminobutyric acid receptor subunit gamma-2target
ProgabideGamma-aminobutyric acid receptor subunit alpha-1target
ProgabideGamma-aminobutyric acid type B receptor subunit 1target
AZD 3355Cellular tumor antigen p53target
GaboxadolProton-coupled amino acid transporter 1transporter
AdipiplonGABA(A) Receptor Benzodiazepine Binding Sitetarget
Arbaclofen PlacarbilMonocarboxylate transporter 1transporter
Arbaclofen PlacarbilGamma-aminobutyric acid type B receptor subunit 1target
Arbaclofen PlacarbilGamma-aminobutyric acid type B receptor subunit 2target
MuscimolGamma-aminobutyric acid receptor subunit alpha-1target
MuscimolGamma-aminobutyric acid receptor subunit beta-3target
MuscimolGamma-aminobutyric acid receptor subunit gamma-2target
ZaleplonGamma-aminobutyric acid receptor subunit alpha-1target
ZaleplonCytochrome P450 3A4enzyme
ZaleplonAldehyde oxidaseenzyme
ZaleplonCytochrome P450 3A5enzyme
ZaleplonCytochrome P450 3A7enzyme
ClobazamCytochrome P450 2C19enzyme
ClobazamCytochrome P450 3A4enzyme
ClobazamCytochrome P450 2B6enzyme
ClobazamCytochrome P450 2C18enzyme
ClobazamSodium- and chloride-dependent GABA transporter 1transporter
ClobazamSodium- and chloride-dependent GABA transporter 3transporter
ClobazamP-glycoprotein 1transporter
ClobazamGABA(A) Receptortarget
ClobazamCytochrome P450 2D6enzyme
ClobazamGABA(A) Receptor Benzodiazepine Binding Sitetarget