Identification

Name
Clobazam
Accession Number
DB00349  (APRD00307)
Type
Small Molecule
Groups
Approved, Illicit
Description

Clobazam belongs to the 1,5-benzodiazepine class of drugs and is expected to have a better side-effect profile compared to older 1,4-benzodiazepines. It has been marketed as an anxiolytic since 1975 and an anticonvulsant since 1984. The oral preparation was FDA approved on October 21, 2011. An oral suspension is expected to be available in 2013.

Structure
Thumb
Synonyms
  • 1-phenyl-5-methyl-8-chloro-1,2,4,5-tetrahydro-2,4-dioxo-3H-1,5-benzodiazepine
  • 7-Chloro-1-methyl-5-phenyl-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione
  • Clobazam
  • Clobazamum
External IDs
H 4723 / H-4723 / HR 376 / HR-376 / LM 2717 / LM-2717
Product Images
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Clobazam-10Tablet10 mgOralPro Doc Limitee2003-12-09Not applicableCanada
Frisium Tab 10mgTablet10 mgOralHoechst Canada Inc.1991-12-311996-08-29Canada
Frisium Tablet 10mgTablet10 mgOralLundbeck Inc.1997-03-24Not applicableCanada
Frisium Tablets 10mgTablet10 mgOralHoechst Roussel Canada Inc.1994-12-311999-08-11Canada
OnfiTablet5 mg/1OralLundbeck Inc.2011-10-212016-02-28Us
OnfiTablet20 mg/1OralLundbeck Pharmaceuticals Llc2013-12-10Not applicableUs67386 0315 01 nlmimage10 123f892c
OnfiTablet20 mg/1OralLundbeck Inc.2013-08-122016-06-30Us
OnfiTablet10 mg/1OralLundbeck Pharmaceuticals Llc2013-12-10Not applicableUs67386 0314 01 nlmimage10 173f8b9c
OnfiTablet10 mg/1OralLundbeck Inc.2013-08-122016-04-30Us
OnfiSuspension2.5 mg/mLOralLundbeck Pharmaceuticals Llc2012-12-14Not applicableUs
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-clobazamTablet10 mgOralApotex Corporation2001-11-28Not applicableCanada
Dom-clobazamTablet10 mgOralDominion Pharmacal2003-03-272016-10-25Canada
Ntp-clobazamTablet10 mgOralTevaNot applicableNot applicableCanada
PMS-clobazamTablet10 mgOralPharmascience Inc2001-11-16Not applicableCanada
Ratio-clobazamTablet10 mgOralRatiopharm Inc Division Of Teva Canada Limited1998-11-302010-08-02Canada
Teva-clobazamTablet10 mgOralTeva1998-07-07Not applicableCanada
International/Other Brands
Aedon (Sanofi-Aventis) / Castilium (Sanofi-Aventis) / Clobam (Square) / Clobamax (Sherfarma) / Frisium (Sanofi-Aventis) / Grifoclobam (Chile) / Mystan (Dainippon Sumitomo) / Noiafren (Sanofi Aventis) / Sederlona / Urbanil (Sanofi-Aventis) / Urbanol (Sanofi-Aventis) / Urbanyl (Sanofi-Aventis) / Venium (Hudson)
Categories
UNII
2MRO291B4U
CAS number
22316-47-8
Weight
Average: 300.74
Monoisotopic: 300.066555377
Chemical Formula
C16H13ClN2O2
InChI Key
CXOXHMZGEKVPMT-UHFFFAOYSA-N
InChI
InChI=1S/C16H13ClN2O2/c1-18-13-8-7-11(17)9-14(13)19(16(21)10-15(18)20)12-5-3-2-4-6-12/h2-9H,10H2,1H3
IUPAC Name
7-chloro-1-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-2,4-dione
SMILES
CN1C2=C(C=C(Cl)C=C2)N(C2=CC=CC=C2)C(=O)CC1=O

Pharmacology

Indication

For treatment and management of epilepsy and seizures associated with Lennox-Gastaut syndrome, a difficult-to-treat form of childhood epilepsy.

Structured Indications
Pharmacodynamics

Similar to other benzodiazepines, clobazam binds to the interface of the α and γ2-subunit of the GABA-A receptor. However, it is considered a partial agonist to GABA-A receptors which sets clobazam apart from 1,4-benzodiazepines which are full agonist. The significance of this difference is that one may experience less sedation with clobazam than with other benzodiazepines. Unlike the endogenous GABA ligand, clobazam binds allosterically to the GABA receptor to increase the frequency of the chloride channel opening and membrane permeability to chloride ions. Pharmacodynamic tolerance has been demonstrated in animal models.

Mechanism of action

Clobazam binds at distinct binding sites associated with the chloride ionopore at the post-synaptic GABA receptor. These GABA receptors are in various locations in the CNS (limbic, reticular formation) and clobazam increases the duration of time for which the chloride ionopore is open. As a result, hyper polarization and stabilization of the membrane occur as the post-synaptic inhibitory effect of GABA is enhanced.

TargetActionsOrganism
AGABA-A receptor (anion channel)
positive allosteric modulator
Human
Absorption

After oral administration of clobazam, it is almost completely absorbed (87% of dose). Bioavailability relative to solution was almost at 100%. Food does not affect absorption. Tmax = 1-3 hours.

Volume of distribution

Vdss = 100 L. This high volume of distribution suggests extensive distribution to body tissues.

Protein binding

Clobazam is the primary circulating entity in the serum and is highly protein-bound (80-90%).

Metabolism

Clobazam is extensively metabolized in the liver via N-demethylation and hydroxylation. Clobazam has two major metabolites: N-desmethylclobazam (norclobazam) and 4'-hydroxyclobazam, the former of which is active. Norclobazam is one-fourth the potency of clobazam. The main enzyme that facilitates the process of N-demethylation is CYP3A4, and to a lesser extent by CYP2C19 and CYP2B6. Norclobazam itself is also metabolized via hydroxylation, primarily by CYP2C19. The formation of 4'-hydroxyclobazam is facilitated by CYP2C18 and CYP2C19. A factor in determining extent of metabolism is the genetic profile of the individual patient as CYP2C19 is a polymorphic enzyme.

Route of elimination

Clobazam is eliminated via the urine (~94%) as metabolites.

Half life

The mean elimination half life of an oral dose of clobazam 40 mg is 32 hours. It's main metabolite, norclobazam, as a half life of 57 hours. The half life in adult patients with epilepsy are higher than those that are healthy.

Clearance

Median estimated clearance = 2.49 L/h

Toxicity

The most common adverse effects include somnolence, pyrexia, upper respiratory tract infection, and lethargy.

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Interacting Gene/EnzymeAllele nameGenotype(s)Defining Change(s)Type(s)DescriptionDetails
Cytochrome P450 2C19CYP2C19*2(A;A) / (A;G)G > A/CADR Directly StudiedPatients with this genotype have reduced metabolism of clobazam.Details
Cytochrome P450 2C19CYP2C19*2ANot Available681G>AADR InferredClobazem is metabolized into N-desmethylclobazem (NCLB) mostly by CYP3A4. NCLB is primarily metabolized by 2C19. Those with one 2C19*2 allele mutation (1*/2*) are intermediate metabolizers of NCLB. Those with two (2*/2*) mutations will metabolize NCLB poorly in comparisone to extensive metabolizers (1*/1*). Levels of NCLB can be five times higher in poor metabolizers, and two times higher in intermediate metabolizers as compared to individuals who are extensive metabolizers. The safety and efficacy of clobazem may be affected by polymorphic expression of CYP2C19*2.Details
Cytochrome P450 2C19CYP2C19*2BNot Available681G>AADR InferredClobazem is metabolized into N-desmethylclobazem (NCLB) mostly by CYP3A4. NCLB is primarily metabolized by 2C19. Those with one 2C19*2 allele mutation (1*/2*) are intermediate metabolizers of NCLB. Those with two (2*/2*) mutations will metabolize NCLB poorly in comparisone to extensive metabolizers (1*/1*). Levels of NCLB can be five times higher in poor metabolizers, and two times higher in intermediate metabolizers as compared to individuals who are extensive metabolizers. The safety and efficacy of clobazem may be affected by polymorphic expression of CYP2C19*2.Details
Cytochrome P450 2C19CYP2C19*3Not Available636G>AADR InferredClobazem is metabolized into N-desmethylclobazem (NCLB) mostly by CYP3A4. NCLB is primarily metabolized by 2C19. Those with one 2C19*2 allele mutation (1*/2*) are intermediate metabolizers of NCLB. Those with two (2*/2*) mutations will metabolize NCLB poorly in comparisone to extensive metabolizers (1*/1*). Levels of NCLB can be five times higher in poor metabolizers, and two times higher in intermediate metabolizers as compared to individuals who are extensive metabolizers. The safety and efficacy of clobazem may be affected by polymorphic expression of CYP2C19*2.Details
Cytochrome P450 2C19CYP2C19*4Not Available1A>GADR InferredClobazem is metabolized into N-desmethylclobazem (NCLB) mostly by CYP3A4. NCLB is primarily metabolized by 2C19. Those with one 2C19*2 allele mutation (1*/2*) are intermediate metabolizers of NCLB. Those with two (2*/2*) mutations will metabolize NCLB poorly in comparisone to extensive metabolizers (1*/1*). Levels of NCLB can be five times higher in poor metabolizers, and two times higher in intermediate metabolizers as compared to individuals who are extensive metabolizers. The safety and efficacy of clobazem may be affected by polymorphic expression of CYP2C19*2.Details
Cytochrome P450 2C19CYP2C19*5Not Available1297C>TADR InferredClobazem is metabolized into N-desmethylclobazem (NCLB) mostly by CYP3A4. NCLB is primarily metabolized by 2C19. Those with one 2C19*2 allele mutation (1*/2*) are intermediate metabolizers of NCLB. Those with two (2*/2*) mutations will metabolize NCLB poorly in comparisone to extensive metabolizers (1*/1*). Levels of NCLB can be five times higher in poor metabolizers, and two times higher in intermediate metabolizers as compared to individuals who are extensive metabolizers. The safety and efficacy of clobazem may be affected by polymorphic expression of CYP2C19*2.Details
Cytochrome P450 2C19CYP2C19*6Not Available395G>AADR InferredClobazem is metabolized into N-desmethylclobazem (NCLB) mostly by CYP3A4. NCLB is primarily metabolized by 2C19. Those with one 2C19*2 allele mutation (1*/2*) are intermediate metabolizers of NCLB. Those with two (2*/2*) mutations will metabolize NCLB poorly in comparisone to extensive metabolizers (1*/1*). Levels of NCLB can be five times higher in poor metabolizers, and two times higher in intermediate metabolizers as compared to individuals who are extensive metabolizers. The safety and efficacy of clobazem may be affected by polymorphic expression of CYP2C19*2.Details
Cytochrome P450 2C19CYP2C19*7Not Available19294T>AADR InferredClobazem is metabolized into N-desmethylclobazem (NCLB) mostly by CYP3A4. NCLB is primarily metabolized by 2C19. Those with one 2C19*2 allele mutation (1*/2*) are intermediate metabolizers of NCLB. Those with two (2*/2*) mutations will metabolize NCLB poorly in comparisone to extensive metabolizers (1*/1*). Levels of NCLB can be five times higher in poor metabolizers, and two times higher in intermediate metabolizers as compared to individuals who are extensive metabolizers. The safety and efficacy of clobazem may be affected by polymorphic expression of CYP2C19*2.Details
Cytochrome P450 2C19CYP2C19*22Not Available557G>C / 991A>GADR InferredClobazem is metabolized into N-desmethylclobazem (NCLB) mostly by CYP3A4. NCLB is primarily metabolized by 2C19. Those with one 2C19*2 allele mutation (1*/2*) are intermediate metabolizers of NCLB. Those with two (2*/2*) mutations will metabolize NCLB poorly in comparisone to extensive metabolizers (1*/1*). Levels of NCLB can be five times higher in poor metabolizers, and two times higher in intermediate metabolizers as compared to individuals who are extensive metabolizers. The safety and efficacy of clobazem may be affected by polymorphic expression of CYP2C19*2.Details
Cytochrome P450 2C19CYP2C19*24Not Available99C>T / 991A>G  … show all ADR InferredClobazem is metabolized into N-desmethylclobazem (NCLB) mostly by CYP3A4. NCLB is primarily metabolized by 2C19. Those with one 2C19*2 allele mutation (1*/2*) are intermediate metabolizers of NCLB. Those with two (2*/2*) mutations will metabolize NCLB poorly in comparisone to extensive metabolizers (1*/1*). Levels of NCLB can be five times higher in poor metabolizers, and two times higher in intermediate metabolizers as compared to individuals who are extensive metabolizers. The safety and efficacy of clobazem may be affected by polymorphic expression of CYP2C19*2.Details
Cytochrome P450 2C19CYP2C19*35Not Available12662A>GADR InferredClobazem is metabolized into N-desmethylclobazem (NCLB) mostly by CYP3A4. NCLB is primarily metabolized by 2C19. Those with one 2C19*2 allele mutation (1*/2*) are intermediate metabolizers of NCLB. Those with two (2*/2*) mutations will metabolize NCLB poorly in comparisone to extensive metabolizers (1*/1*). Levels of NCLB can be five times higher in poor metabolizers, and two times higher in intermediate metabolizers as compared to individuals who are extensive metabolizers. The safety and efficacy of clobazem may be affected by polymorphic expression of CYP2C19*2.Details

Interactions

Drug Interactions
DrugInteractionDrug group
4-MethoxyamphetamineThe metabolism of 4-Methoxyamphetamine can be decreased when combined with Clobazam.Experimental, Illicit
AbirateroneThe metabolism of Clobazam can be decreased when combined with Abiraterone.Approved
AcetaminophenThe metabolism of Acetaminophen can be decreased when combined with Clobazam.Approved
AcetylcholineThe metabolism of Acetylcholine can be decreased when combined with Clobazam.Approved
AjmalineThe metabolism of Ajmaline can be decreased when combined with Clobazam.Approved, Investigational
AlmotriptanThe metabolism of Almotriptan can be decreased when combined with Clobazam.Approved, Investigational
AlogliptinThe metabolism of Alogliptin can be decreased when combined with Clobazam.Approved
AlprenololThe metabolism of Alprenolol can be decreased when combined with Clobazam.Approved, Withdrawn
Ambroxol acefyllinateThe therapeutic efficacy of Clobazam can be decreased when used in combination with Ambroxol acefyllinate.Experimental, Investigational
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Clobazam.Approved, Withdrawn
AmiodaroneThe metabolism of Clobazam can be decreased when combined with Amiodarone.Approved, Investigational
AmitriptylineThe metabolism of Amitriptyline can be decreased when combined with Clobazam.Approved
AmoxapineThe metabolism of Amoxapine can be decreased when combined with Clobazam.Approved
AmphetamineThe metabolism of Amphetamine can be decreased when combined with Clobazam.Approved, Illicit
AmprenavirThe metabolism of Amprenavir can be decreased when combined with Clobazam.Approved
AmsacrineThe metabolism of Amsacrine can be decreased when combined with Clobazam.Approved
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Clobazam.Approved
AprepitantThe serum concentration of Clobazam can be increased when it is combined with Aprepitant.Approved, Investigational
AprindineThe metabolism of Aprindine can be decreased when combined with Clobazam.Approved
ArformoterolThe metabolism of Arformoterol can be decreased when combined with Clobazam.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be decreased when it is combined with Clobazam.Approved, Investigational
ArmodafinilThe metabolism of Clobazam can be decreased when combined with Armodafinil.Approved, Investigational
ArtemetherThe metabolism of Artemether can be decreased when combined with Clobazam.Approved
AstemizoleThe metabolism of Astemizole can be decreased when combined with Clobazam.Approved, Withdrawn
AtazanavirThe metabolism of Clobazam can be decreased when combined with Atazanavir.Approved, Investigational
AtomoxetineThe metabolism of Clobazam can be decreased when combined with Atomoxetine.Approved
AzelastineThe metabolism of Azelastine can be decreased when combined with Clobazam.Approved
BenzatropineThe metabolism of Benzatropine can be decreased when combined with Clobazam.Approved
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Clobazam.Approved
BepridilThe metabolism of Bepridil can be decreased when combined with Clobazam.Approved, Withdrawn
BetaxololThe metabolism of Betaxolol can be decreased when combined with Clobazam.Approved
BisoprololThe metabolism of Bisoprolol can be decreased when combined with Clobazam.Approved
BoceprevirThe metabolism of Clobazam can be decreased when combined with Boceprevir.Approved, Withdrawn
BortezomibThe metabolism of Clobazam can be decreased when combined with Bortezomib.Approved, Investigational
BosentanThe serum concentration of Clobazam can be decreased when it is combined with Bosentan.Approved, Investigational
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Clobazam.Approved
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Clobazam.Approved
BufuralolThe metabolism of Bufuralol can be decreased when combined with Clobazam.Experimental, Investigational
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Clobazam.Approved, Investigational
BuprenorphineThe metabolism of Buprenorphine can be decreased when combined with Clobazam.Approved, Illicit, Investigational, Vet Approved
BupropionThe metabolism of Bupropion can be decreased when combined with Clobazam.Approved
BuspironeThe metabolism of Buspirone can be decreased when combined with Clobazam.Approved, Investigational
CaffeineThe metabolism of Caffeine can be decreased when combined with Clobazam.Approved
CaptoprilThe metabolism of Captopril can be decreased when combined with Clobazam.Approved
CarbamazepineThe metabolism of Clobazam can be increased when combined with Carbamazepine.Approved, Investigational
CariprazineThe metabolism of Cariprazine can be decreased when combined with Clobazam.Approved
CarteololThe metabolism of Carteolol can be decreased when combined with Clobazam.Approved
CarvedilolThe metabolism of Carvedilol can be decreased when combined with Clobazam.Approved, Investigational
CephalexinThe metabolism of Cephalexin can be decreased when combined with Clobazam.Approved, Vet Approved
CeritinibThe serum concentration of Clobazam can be increased when it is combined with Ceritinib.Approved
CevimelineThe metabolism of Cevimeline can be decreased when combined with Clobazam.Approved
ChloramphenicolThe metabolism of Clobazam can be decreased when combined with Chloramphenicol.Approved, Vet Approved
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Clobazam.Approved, Illicit
ChloroquineThe metabolism of Chloroquine can be decreased when combined with Clobazam.Approved, Vet Approved
ChlorotrianiseneThe serum concentration of Chlorotrianisene can be decreased when it is combined with Clobazam.Investigational, Withdrawn
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Clobazam.Approved
ChlorpromazineThe metabolism of Chlorpromazine can be decreased when combined with Clobazam.Approved, Vet Approved
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Clobazam.Approved
CholecalciferolThe metabolism of Clobazam can be decreased when combined with Cholecalciferol.Approved, Nutraceutical
CilostazolThe metabolism of Cilostazol can be decreased when combined with Clobazam.Approved
CimetidineThe metabolism of Clobazam can be decreased when combined with Cimetidine.Approved
CinnarizineThe metabolism of Cinnarizine can be decreased when combined with Clobazam.Approved, Investigational
CitalopramThe metabolism of Citalopram can be decreased when combined with Clobazam.Approved
ClarithromycinThe metabolism of Clobazam can be decreased when combined with Clarithromycin.Approved
ClemastineThe metabolism of Clobazam can be decreased when combined with Clemastine.Approved
ClevidipineThe metabolism of Clevidipine can be decreased when combined with Clobazam.Approved
ClomipramineThe metabolism of Clomipramine can be decreased when combined with Clobazam.Approved, Vet Approved
ClonidineThe metabolism of Clonidine can be decreased when combined with Clobazam.Approved
ClopidogrelThe metabolism of Clobazam can be decreased when combined with Clopidogrel.Approved
ClotrimazoleThe metabolism of Clobazam can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineThe risk or severity of adverse effects can be increased when Clobazam is combined with Clozapine.Approved
CobicistatThe metabolism of Clobazam can be decreased when combined with Cobicistat.Approved
CodeineThe therapeutic efficacy of Codeine can be decreased when used in combination with Clobazam.Approved, Illicit
ConivaptanThe serum concentration of Conivaptan can be increased when it is combined with Clobazam.Approved, Investigational
Conjugated estrogensThe serum concentration of Conjugated estrogens can be decreased when it is combined with Clobazam.Approved
CrizotinibThe metabolism of Clobazam can be decreased when combined with Crizotinib.Approved
CyclobenzaprineThe metabolism of Cyclobenzaprine can be decreased when combined with Clobazam.Approved
CyclophosphamideThe metabolism of Cyclophosphamide can be decreased when combined with Clobazam.Approved, Investigational
CyclosporineThe metabolism of Clobazam can be decreased when combined with Cyclosporine.Approved, Investigational, Vet Approved
DabrafenibThe serum concentration of Clobazam can be decreased when it is combined with Dabrafenib.Approved
DapagliflozinThe metabolism of Dapagliflozin can be decreased when combined with Clobazam.Approved
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Clobazam.Approved, Investigational
DarunavirThe metabolism of Clobazam can be decreased when combined with Darunavir.Approved
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Clobazam.Approved
DasatinibThe serum concentration of Clobazam can be increased when it is combined with Dasatinib.Approved, Investigational
DebrisoquinThe metabolism of Debrisoquin can be decreased when combined with Clobazam.Approved, Investigational
DeferasiroxThe serum concentration of Clobazam can be decreased when it is combined with Deferasirox.Approved, Investigational
DelavirdineThe metabolism of Clobazam can be decreased when combined with Delavirdine.Approved
DesipramineThe metabolism of Desipramine can be decreased when combined with Clobazam.Approved
DesogestrelThe serum concentration of Desogestrel can be decreased when it is combined with Clobazam.Approved
DeutetrabenazineThe metabolism of Deutetrabenazine can be decreased when combined with Clobazam.Approved, Investigational
Dexchlorpheniramine maleateThe metabolism of Dexchlorpheniramine maleate can be decreased when combined with Clobazam.Approved
DexfenfluramineThe metabolism of Dexfenfluramine can be decreased when combined with Clobazam.Approved, Illicit, Investigational, Withdrawn
DexmethylphenidateThe metabolism of Dexmethylphenidate can be decreased when combined with Clobazam.Approved
DextroamphetamineThe metabolism of Dextroamphetamine can be decreased when combined with Clobazam.Approved, Illicit
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Clobazam.Approved
DienestrolThe serum concentration of Dienestrol can be decreased when it is combined with Clobazam.Approved, Investigational
DienogestThe serum concentration of Dienogest can be decreased when it is combined with Clobazam.Approved
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be decreased when it is combined with Clobazam.Approved, Investigational
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Clobazam.Approved, Illicit
DihydroergotamineThe metabolism of Clobazam can be decreased when combined with Dihydroergotamine.Approved
DiltiazemThe metabolism of Clobazam can be decreased when combined with Diltiazem.Approved
DiphenhydramineThe metabolism of Diphenhydramine can be decreased when combined with Clobazam.Approved
DolasetronThe metabolism of Dolasetron can be decreased when combined with Clobazam.Approved
DomperidoneThe metabolism of Domperidone can be decreased when combined with Clobazam.Approved, Investigational, Vet Approved
DonepezilThe metabolism of Donepezil can be decreased when combined with Clobazam.Approved
DopamineThe metabolism of Dopamine can be decreased when combined with Clobazam.Approved
DoxazosinThe metabolism of Doxazosin can be decreased when combined with Clobazam.Approved
DoxepinThe metabolism of Doxepin can be decreased when combined with Clobazam.Approved
DoxofyllineThe serum concentration of Doxofylline can be decreased when it is combined with Clobazam.Approved, Investigational
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Clobazam.Approved, Investigational
DoxorubicinThe metabolism of Doxorubicin can be decreased when combined with Clobazam.Approved, Investigational
DoxycyclineThe metabolism of Clobazam can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DronedaroneThe metabolism of Clobazam can be decreased when combined with Dronedarone.Approved
DrospirenoneThe serum concentration of Drospirenone can be decreased when it is combined with Clobazam.Approved
DuloxetineThe metabolism of Duloxetine can be decreased when combined with Clobazam.Approved
EfavirenzThe metabolism of Clobazam can be decreased when combined with Efavirenz.Approved, Investigational
EletriptanThe metabolism of Eletriptan can be decreased when combined with Clobazam.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Clobazam.Approved
EnasidenibThe metabolism of Enasidenib can be decreased when combined with Clobazam.Approved
EncainideThe metabolism of Encainide can be decreased when combined with Clobazam.Approved, Investigational, Withdrawn
EnclomipheneThe metabolism of Enclomiphene can be decreased when combined with Clobazam.Investigational
EnzalutamideThe serum concentration of Clobazam can be decreased when it is combined with Enzalutamide.Approved
EpinastineThe metabolism of Epinastine can be decreased when combined with Clobazam.Approved, Investigational
ErlotinibThe metabolism of Erlotinib can be decreased when combined with Clobazam.Approved, Investigational
ErythromycinThe metabolism of Clobazam can be decreased when combined with Erythromycin.Approved, Vet Approved
EscitalopramThe metabolism of Escitalopram can be decreased when combined with Clobazam.Approved, Investigational
Eslicarbazepine acetateThe metabolism of Clobazam can be decreased when combined with Eslicarbazepine acetate.Approved
EsmirtazapineThe metabolism of Esmirtazapine can be decreased when combined with Clobazam.Investigational
EsomeprazoleThe metabolism of Clobazam can be decreased when combined with Esomeprazole.Approved, Investigational
EstradiolThe serum concentration of Estradiol can be decreased when it is combined with Clobazam.Approved, Investigational, Vet Approved
EstramustineThe serum concentration of Estramustine can be decreased when it is combined with Clobazam.Approved
Estrogens, esterifiedThe serum concentration of Estrogens, esterified can be decreased when it is combined with Clobazam.Approved
Estrone sulfateThe serum concentration of Estrone sulfate can be decreased when it is combined with Clobazam.Approved
EthanolEthanol may increase the central nervous system depressant (CNS depressant) activities of Clobazam.Approved
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Clobazam.Approved
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Clobazam.Approved, Illicit
Ethynodiol diacetateThe serum concentration of Ethynodiol diacetate can be decreased when it is combined with Clobazam.Approved
EtonogestrelThe serum concentration of Etonogestrel can be decreased when it is combined with Clobazam.Approved, Investigational
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Clobazam.Approved, Investigational
EtravirineThe metabolism of Clobazam can be decreased when combined with Etravirine.Approved
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Clobazam.Approved
FingolimodThe metabolism of Fingolimod can be decreased when combined with Clobazam.Approved, Investigational
FlecainideThe metabolism of Flecainide can be decreased when combined with Clobazam.Approved, Withdrawn
FluconazoleThe metabolism of Clobazam can be decreased when combined with Fluconazole.Approved
FlunarizineThe metabolism of Flunarizine can be decreased when combined with Clobazam.Approved
FluoxetineThe metabolism of Fluoxetine can be decreased when combined with Clobazam.Approved, Vet Approved
FluphenazineThe metabolism of Fluphenazine can be decreased when combined with Clobazam.Approved
FluvastatinThe metabolism of Fluvastatin can be decreased when combined with Clobazam.Approved
FluvoxamineThe metabolism of Clobazam can be decreased when combined with Fluvoxamine.Approved, Investigational
FormoterolThe metabolism of Formoterol can be decreased when combined with Clobazam.Approved, Investigational
FosamprenavirThe metabolism of Clobazam can be decreased when combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Clobazam can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinThe serum concentration of Fosphenytoin can be increased when it is combined with Clobazam.Approved
Fusidic AcidThe serum concentration of Clobazam can be increased when it is combined with Fusidic Acid.Approved
GalantamineThe metabolism of Galantamine can be decreased when combined with Clobazam.Approved
GefitinibThe metabolism of Gefitinib can be decreased when combined with Clobazam.Approved, Investigational
GemfibrozilThe metabolism of Clobazam can be decreased when combined with Gemfibrozil.Approved
GestodeneThe serum concentration of Gestodene can be decreased when it is combined with Clobazam.Approved, Investigational
GranisetronThe metabolism of Granisetron can be decreased when combined with Clobazam.Approved, Investigational
HalofantrineThe metabolism of Halofantrine can be decreased when combined with Clobazam.Approved
HaloperidolThe metabolism of Haloperidol can be decreased when combined with Clobazam.Approved
HalothaneThe metabolism of Halothane can be decreased when combined with Clobazam.Approved, Vet Approved
HexestrolThe serum concentration of Hexestrol can be decreased when it is combined with Clobazam.Withdrawn
HyaluronidaseThe therapeutic efficacy of Clobazam can be decreased when used in combination with Hyaluronidase.Approved, Investigational
HydrocodoneThe metabolism of Hydrocodone can be decreased when combined with Clobazam.Approved, Illicit
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Clobazam.Approved, Illicit
IbrutinibThe metabolism of Ibrutinib can be decreased when combined with Clobazam.Approved
IdarubicinThe metabolism of Idarubicin can be decreased when combined with Clobazam.Approved
IdelalisibThe metabolism of Clobazam can be decreased when combined with Idelalisib.Approved
IloperidoneThe metabolism of Iloperidone can be decreased when combined with Clobazam.Approved
ImatinibThe metabolism of Clobazam can be decreased when combined with Imatinib.Approved
ImipramineThe metabolism of Imipramine can be decreased when combined with Clobazam.Approved
IndinavirThe metabolism of Clobazam can be decreased when combined with Indinavir.Approved
Ipratropium bromideThe metabolism of Ipratropium bromide can be decreased when combined with Clobazam.Approved
IsavuconazoniumThe metabolism of Clobazam can be decreased when combined with Isavuconazonium.Approved, Investigational
IsoniazidThe metabolism of Clobazam can be decreased when combined with Isoniazid.Approved
IsradipineThe metabolism of Clobazam can be decreased when combined with Isradipine.Approved
ItraconazoleThe metabolism of Clobazam can be decreased when combined with Itraconazole.Approved, Investigational
IvacaftorThe serum concentration of Clobazam can be increased when it is combined with Ivacaftor.Approved
IxazomibThe metabolism of Ixazomib can be decreased when combined with Clobazam.Approved
KetoconazoleThe metabolism of Clobazam can be decreased when combined with Ketoconazole.Approved, Investigational
LabetalolThe metabolism of Labetalol can be decreased when combined with Clobazam.Approved
LetermovirThe metabolism of Letermovir can be decreased when combined with Clobazam.Approved
LevodopaThe metabolism of Levodopa can be decreased when combined with Clobazam.Approved
LevomilnacipranThe metabolism of Levomilnacipran can be decreased when combined with Clobazam.Approved
LevonorgestrelThe serum concentration of Levonorgestrel can be decreased when it is combined with Clobazam.Approved, Investigational
LidocaineThe metabolism of Lidocaine can be decreased when combined with Clobazam.Approved, Vet Approved
LisurideThe metabolism of Lisuride can be decreased when combined with Clobazam.Approved, Investigational
LobeglitazoneThe metabolism of Clobazam can be decreased when combined with Lobeglitazone.Approved, Investigational
LomustineThe metabolism of Lomustine can be decreased when combined with Clobazam.Approved
LoperamideThe metabolism of Loperamide can be decreased when combined with Clobazam.Approved
LopinavirThe metabolism of Clobazam can be decreased when combined with Lopinavir.Approved
LoratadineThe metabolism of Loratadine can be decreased when combined with Clobazam.Approved
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Clobazam.Approved
LovastatinThe metabolism of Clobazam can be decreased when combined with Lovastatin.Approved, Investigational
LuliconazoleThe serum concentration of Clobazam can be increased when it is combined with Luliconazole.Approved
LumacaftorThe serum concentration of Clobazam can be decreased when it is combined with Lumacaftor.Approved
LynestrenolThe serum concentration of Lynestrenol can be decreased when it is combined with Clobazam.Investigational
MaprotilineThe metabolism of Maprotiline can be decreased when combined with Clobazam.Approved
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with Clobazam.Approved, Investigational
MefloquineThe therapeutic efficacy of Clobazam can be decreased when used in combination with Mefloquine.Approved
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Clobazam.Investigational, Withdrawn
MequitazineThe metabolism of Mequitazine can be decreased when combined with Clobazam.Approved
MesoridazineThe metabolism of Mesoridazine can be decreased when combined with Clobazam.Approved, Investigational
MestranolThe serum concentration of Mestranol can be decreased when it is combined with Clobazam.Approved
MethadoneClobazam may increase the central nervous system depressant (CNS depressant) activities of Methadone.Approved
MethallenestrilThe serum concentration of Methallenestril can be decreased when it is combined with Clobazam.Experimental
MethamphetamineThe metabolism of Methamphetamine can be decreased when combined with Clobazam.Approved, Illicit
MethotrimeprazineThe metabolism of Methotrimeprazine can be decreased when combined with Clobazam.Approved
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Clobazam.Approved, Investigational, Vet Approved
MethylphenidateThe metabolism of Methylphenidate can be decreased when combined with Clobazam.Approved, Investigational
MethyprylonThe metabolism of Methyprylon can be decreased when combined with Clobazam.Approved, Illicit, Withdrawn
MetoclopramideThe metabolism of Metoclopramide can be decreased when combined with Clobazam.Approved, Investigational
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Clobazam.Approved, Investigational
MexiletineThe metabolism of Mexiletine can be decreased when combined with Clobazam.Approved
MianserinThe therapeutic efficacy of Clobazam can be decreased when used in combination with Mianserin.Approved, Investigational
MifepristoneThe serum concentration of Clobazam can be increased when it is combined with Mifepristone.Approved, Investigational
MinaprineThe metabolism of Minaprine can be decreased when combined with Clobazam.Approved
MirabegronThe metabolism of Mirabegron can be decreased when combined with Clobazam.Approved
MirtazapineThe metabolism of Mirtazapine can be decreased when combined with Clobazam.Approved
MitotaneThe serum concentration of Clobazam can be decreased when it is combined with Mitotane.Approved
MoclobemideThe metabolism of Moclobemide can be decreased when combined with Clobazam.Approved
ModafinilThe metabolism of Clobazam can be decreased when combined with Modafinil.Approved, Investigational
MorphineThe metabolism of Morphine can be decreased when combined with Clobazam.Approved, Investigational
NateglinideThe metabolism of Nateglinide can be decreased when combined with Clobazam.Approved, Investigational
NebivololThe serum concentration of Nebivolol can be increased when it is combined with Clobazam.Approved, Investigational
NefazodoneThe metabolism of Clobazam can be decreased when combined with Nefazodone.Approved, Withdrawn
NelfinavirThe metabolism of Clobazam can be decreased when combined with Nelfinavir.Approved
NetupitantThe serum concentration of Clobazam can be increased when it is combined with Netupitant.Approved
NevirapineThe metabolism of Clobazam can be increased when combined with Nevirapine.Approved
NicardipineThe metabolism of Nicardipine can be decreased when combined with Clobazam.Approved
NicergolineThe metabolism of Nicergoline can be decreased when combined with Clobazam.Approved, Investigational
NicotineThe metabolism of Nicotine can be decreased when combined with Clobazam.Approved
NifedipineThe metabolism of Nifedipine can be decreased when combined with Clobazam.Approved
NilotinibThe metabolism of Clobazam can be decreased when combined with Nilotinib.Approved, Investigational
NitrofuralThe metabolism of Nitrofural can be decreased when combined with Clobazam.Approved, Investigational, Vet Approved
NorelgestrominThe serum concentration of Norelgestromin can be decreased when it is combined with Clobazam.Approved
NorgestimateThe serum concentration of Norgestimate can be decreased when it is combined with Clobazam.Approved
NorgestrelThe serum concentration of Norgestrel can be decreased when it is combined with Clobazam.Approved
NortriptylineThe metabolism of Nortriptyline can be decreased when combined with Clobazam.Approved
OlanzapineThe risk or severity of adverse effects can be increased when Clobazam is combined with Olanzapine.Approved, Investigational
OlanzapineThe metabolism of Olanzapine can be decreased when combined with Clobazam.Approved, Investigational
OlaparibThe metabolism of Clobazam can be decreased when combined with Olaparib.Approved
OmeprazoleThe metabolism of Clobazam can be decreased when combined with Omeprazole.Approved, Investigational, Vet Approved
OndansetronThe metabolism of Ondansetron can be decreased when combined with Clobazam.Approved
OrlistatThe serum concentration of Clobazam can be decreased when it is combined with Orlistat.Approved, Investigational
OsimertinibThe serum concentration of Clobazam can be increased when it is combined with Osimertinib.Approved
OxycodoneThe metabolism of Oxycodone can be decreased when combined with Clobazam.Approved, Illicit, Investigational
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Clobazam.Approved, Investigational, Vet Approved
PalbociclibThe serum concentration of Clobazam can be increased when it is combined with Palbociclib.Approved
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Clobazam.Approved, Investigational
PantoprazoleThe metabolism of Clobazam can be decreased when combined with Pantoprazole.Approved
ParoxetineThe metabolism of Paroxetine can be decreased when combined with Clobazam.Approved, Investigational
PazopanibThe metabolism of Pazopanib can be decreased when combined with Clobazam.Approved
PentamidineThe metabolism of Pentamidine can be decreased when combined with Clobazam.Approved
PentobarbitalThe metabolism of Clobazam can be increased when combined with Pentobarbital.Approved, Vet Approved
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Clobazam.Approved, Investigational
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Clobazam.Approved
PethidineThe metabolism of Pethidine can be decreased when combined with Clobazam.Approved
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Clobazam.Withdrawn
PhenforminThe metabolism of Phenformin can be decreased when combined with Clobazam.Approved, Investigational, Withdrawn
PhenobarbitalThe metabolism of Clobazam can be increased when combined with Phenobarbital.Approved
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Clobazam.Approved, Vet Approved
PindololThe metabolism of Pindolol can be decreased when combined with Clobazam.Approved
PiperazineThe metabolism of Piperazine can be decreased when combined with Clobazam.Approved, Vet Approved
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Clobazam.Approved, Investigational
PonatinibThe metabolism of Ponatinib can be decreased when combined with Clobazam.Approved
PosaconazoleThe metabolism of Clobazam can be decreased when combined with Posaconazole.Approved, Investigational, Vet Approved
PregabalinThe therapeutic efficacy of Clobazam can be decreased when used in combination with Pregabalin.Approved, Illicit, Investigational
PrimidoneThe metabolism of Clobazam can be increased when combined with Primidone.Approved, Vet Approved
ProcainamideThe metabolism of Procainamide can be decreased when combined with Clobazam.Approved
ProchlorperazineThe metabolism of Prochlorperazine can be decreased when combined with Clobazam.Approved, Vet Approved
ProgesteroneThe metabolism of Progesterone can be decreased when combined with Clobazam.Approved, Vet Approved
PromethazineThe metabolism of Promethazine can be decreased when combined with Clobazam.Approved
PropafenoneThe serum concentration of Clobazam can be increased when it is combined with Propafenone.Approved
PropofolThe metabolism of Propofol can be decreased when combined with Clobazam.Approved, Investigational, Vet Approved
PropranololThe metabolism of Propranolol can be decreased when combined with Clobazam.Approved, Investigational
ProtriptylineThe metabolism of Protriptyline can be decreased when combined with Clobazam.Approved
PseudoephedrineThe metabolism of Pseudoephedrine can be decreased when combined with Clobazam.Approved
QuazepamThe serum concentration of Clobazam can be increased when it is combined with Quazepam.Approved, Illicit
QuetiapineThe metabolism of Quetiapine can be decreased when combined with Clobazam.Approved
QuinineThe metabolism of Quinine can be decreased when combined with Clobazam.Approved
RanitidineThe metabolism of Ranitidine can be decreased when combined with Clobazam.Approved
RanolazineThe serum concentration of Clobazam can be increased when it is combined with Ranolazine.Approved, Investigational
RemoxiprideThe metabolism of Remoxipride can be decreased when combined with Clobazam.Approved, Withdrawn
RepinotanThe metabolism of Repinotan can be decreased when combined with Clobazam.Investigational
RifabutinThe metabolism of Clobazam can be increased when combined with Rifabutin.Approved
RifampicinThe metabolism of Clobazam can be increased when combined with Rifampicin.Approved
RifapentineThe metabolism of Clobazam can be increased when combined with Rifapentine.Approved
RilpivirineThe serum concentration of Rilpivirine can be decreased when it is combined with Clobazam.Approved
RisperidoneThe metabolism of Risperidone can be decreased when combined with Clobazam.Approved, Investigational
RitonavirThe metabolism of Ritonavir can be decreased when combined with Clobazam.Approved, Investigational
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Clobazam.Approved
RotigotineThe metabolism of Rotigotine can be decreased when combined with Clobazam.Approved
RucaparibThe metabolism of Rucaparib can be decreased when combined with Clobazam.Approved, Investigational
RupatadineThe metabolism of Rupatadine can be decreased when combined with Clobazam.Approved
SaquinavirThe metabolism of Clobazam can be decreased when combined with Saquinavir.Approved, Investigational
SarilumabThe therapeutic efficacy of Clobazam can be decreased when used in combination with Sarilumab.Approved
SaxagliptinThe serum concentration of Saxagliptin can be decreased when it is combined with Clobazam.Approved
SertindoleThe metabolism of Sertindole can be decreased when combined with Clobazam.Approved, Investigational, Withdrawn
SertralineThe metabolism of Sertraline can be decreased when combined with Clobazam.Approved
SildenafilThe metabolism of Clobazam can be decreased when combined with Sildenafil.Approved, Investigational
SiltuximabThe serum concentration of Clobazam can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Clobazam can be increased when it is combined with Simeprevir.Approved
SimvastatinThe metabolism of Simvastatin can be decreased when combined with Clobazam.Approved
SorafenibThe metabolism of Clobazam can be decreased when combined with Sorafenib.Approved, Investigational
SparteineThe metabolism of Sparteine can be decreased when combined with Clobazam.Experimental
St. John's WortThe serum concentration of Clobazam can be decreased when it is combined with St. John's Wort.Investigational, Nutraceutical
StiripentolThe serum concentration of Stiripentol can be increased when it is combined with Clobazam.Approved
SulfisoxazoleThe metabolism of Clobazam can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
Synthetic Conjugated Estrogens, AThe serum concentration of Synthetic Conjugated Estrogens, A can be decreased when it is combined with Clobazam.Approved
TamoxifenThe serum concentration of the active metabolites of Tamoxifen can be reduced when Tamoxifen is used in combination with Clobazam resulting in a loss in efficacy.Approved
TamsulosinThe metabolism of Tamsulosin can be decreased when combined with Clobazam.Approved, Investigational
TapentadolThe metabolism of Tapentadol can be decreased when combined with Clobazam.Approved
TeduglutideThe serum concentration of Clobazam can be increased when it is combined with Teduglutide.Approved
TegaserodThe metabolism of Tegaserod can be decreased when combined with Clobazam.Investigational, Withdrawn
TelaprevirThe metabolism of Clobazam can be decreased when combined with Telaprevir.Approved, Withdrawn
TelithromycinThe metabolism of Clobazam can be decreased when combined with Telithromycin.Approved
TerfenadineThe metabolism of Terfenadine can be decreased when combined with Clobazam.Withdrawn
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Clobazam.Investigational
TetrabenazineThe metabolism of Tetrabenazine can be decreased when combined with Clobazam.Approved
TheophyllineThe metabolism of Theophylline can be decreased when combined with Clobazam.Approved
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Clobazam.Approved, Withdrawn
ThiotepaThe metabolism of Clobazam can be decreased when combined with Thiotepa.Approved
TiclopidineThe metabolism of Clobazam can be decreased when combined with Ticlopidine.Approved
TimololThe metabolism of Timolol can be decreased when combined with Clobazam.Approved
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Clobazam.Approved
TipranavirThe metabolism of Tipranavir can be decreased when combined with Clobazam.Approved, Investigational
TocilizumabThe serum concentration of Clobazam can be decreased when it is combined with Tocilizumab.Approved
TolterodineThe metabolism of Tolterodine can be decreased when combined with Clobazam.Approved, Investigational
TopiramateThe metabolism of Clobazam can be decreased when combined with Topiramate.Approved
TrabectedinThe metabolism of Trabectedin can be decreased when combined with Clobazam.Approved, Investigational
TramadolThe therapeutic efficacy of Tramadol can be decreased when used in combination with Clobazam.Approved, Investigational
TranylcypromineThe metabolism of Clobazam can be decreased when combined with Tranylcypromine.Approved
TrazodoneThe metabolism of Trazodone can be decreased when combined with Clobazam.Approved, Investigational
TrimipramineThe metabolism of Trimipramine can be decreased when combined with Clobazam.Approved
UmeclidiniumThe metabolism of Umeclidinium can be decreased when combined with Clobazam.Approved
ValbenazineThe metabolism of Valbenazine can be decreased when combined with Clobazam.Approved, Investigational
VemurafenibThe serum concentration of Clobazam can be increased when it is combined with Vemurafenib.Approved
VenlafaxineThe metabolism of Clobazam can be decreased when combined with Venlafaxine.Approved
VerapamilThe metabolism of Clobazam can be decreased when combined with Verapamil.Approved
VernakalantThe metabolism of Vernakalant can be decreased when combined with Clobazam.Approved, Investigational
VilazodoneThe metabolism of Vilazodone can be decreased when combined with Clobazam.Approved
VinblastineThe metabolism of Vinblastine can be decreased when combined with Clobazam.Approved
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Clobazam.Approved, Investigational
VoriconazoleThe metabolism of Clobazam can be decreased when combined with Voriconazole.Approved, Investigational
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Clobazam.Approved
YohimbineThe therapeutic efficacy of Clobazam can be decreased when used in combination with Yohimbine.Approved, Vet Approved
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Clobazam.Approved, Investigational
ZiprasidoneThe metabolism of Clobazam can be decreased when combined with Ziprasidone.Approved
ZolpidemThe metabolism of Zolpidem can be decreased when combined with Clobazam.Approved
ZucapsaicinThe metabolism of Clobazam can be decreased when combined with Zucapsaicin.Approved
ZuclopenthixolThe metabolism of Zuclopenthixol can be decreased when combined with Clobazam.Approved, Investigational
Food Interactions
  • Alcohol increases clobazam absorption by 50%.
  • Take without regard to meals.

References

Synthesis Reference

Hauptmann, K.H., Weber, K.-H., Zeile, K., Danneberg, P. and Giesemann, R.; South African Patent 68/0803; February 7,1968; assigned to Boehringer lngelheim GmbH, Germany.

General References
  1. Freche C: [Study of an anxiolytic, clobazam, in otorhinolaryngology in psychosomatic pharyngeal manifestations]. Sem Hop Ther. 1975 Apr;51(4):261-3. [PubMed:5777]
  2. Authors unspecified: Clobazam in treatment of refractory epilepsy: the Canadian experience. A retrospective study. Canadian Clobazam Cooperative Group. Epilepsia. 1991 May-Jun;32(3):407-16. [PubMed:2044502]
  3. Wildin JD, Pleuvry BJ, Mawer GE, Onon T, Millington L: Respiratory and sedative effects of clobazam and clonazepam in volunteers. Br J Clin Pharmacol. 1990 Feb;29(2):169-77. [PubMed:2106335]
  4. Kilpatrick C, Bury R, Fullinfaw R, Moulds R: Clobazam in the treatment of epilepsy. Clin Exp Neurol. 1987;23:139-44. [PubMed:3117456]
  5. Giarratano M, Standley K, Benbadis SR: Clobazam for treatment of epilepsy. Expert Opin Pharmacother. 2012 Feb;13(2):227-33. doi: 10.1517/14656566.2012.647686. Epub 2012 Jan 13. [PubMed:22242724]
  6. Yang LP, Scott LJ: Clobazam : in patients with Lennox-Gastaut syndrome. CNS Drugs. 2012 Nov;26(11):983-91. doi: 10.1007/s40263-012-0007-0. [PubMed:23034582]
  7. Walzer M, Bekersky I, Blum RA, Tolbert D: Pharmacokinetic drug interactions between clobazam and drugs metabolized by cytochrome P450 isoenzymes. Pharmacotherapy. 2012 Apr;32(4):340-53. doi: 10.1002/j.1875-9114.2012.01028.x. Epub 2012 Mar 15. [PubMed:22422635]
External Links
Human Metabolome Database
HMDB0014493
KEGG Drug
D01253
PubChem Compound
2789
PubChem Substance
46506115
ChemSpider
2687
ChEBI
31413
ChEMBL
CHEMBL70418
Therapeutic Targets Database
DAP000672
PharmGKB
PA10888
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
Wikipedia
Clobazam
ATC Codes
N05BA09 — Clobazam
AHFS Codes
  • 28:12.08 — Benzodiazepines
FDA label
Download (595 KB)
MSDS
Download (57.5 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1, 2CompletedBasic SciencePain, Neuropathic1
2CompletedTreatmentEpilepsies / Epilepsy, Generalized / Seizures1
3CompletedBasic ScienceLow Back Pain (LBP)1
3CompletedTreatmentEpilepsies / Epilepsy, Generalized / Seizures1
3CompletedTreatmentLennox-Gastaut Syndrome (LGS)1
3CompletedTreatmentPain1
3TerminatedTreatmentAnxiety Disorders / Dementias / Depression / Psychosomatic Disorders / Schizophrenic Disorders1
3TerminatedTreatmentDravet Syndrome1
3Unknown StatusTreatmentEpilepsia Partialis Continua / Epilepsies / Kojewnikov's Epilepsy1
3WithdrawnTreatmentDravet Syndrome1
4Active Not RecruitingTreatmentRefractory Epilepsy1
4RecruitingTreatmentEpilepsies2
4RecruitingTreatmentEpilepsies / Feeling Anxious1
Not AvailableRecruitingNot AvailableEpilepsies1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
TabletOral10 mg
SuspensionOral2.5 mg/mL
TabletOral10 mg/1
TabletOral20 mg/1
TabletOral5 mg/1
Prices
Unit descriptionCostUnit
Apo-Clobazam 10 mg Tablet0.23USD tablet
Novo-Clobazam 10 mg Tablet0.23USD tablet
Pms-Clobazam 10 mg Tablet0.23USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)180-182Hauptmann, K.H., Weber, K.-H., Zeile, K., Danneberg, P. and Giesemann, R.; South African Patent 68/0803; February 7,1968; assigned to Boehringer lngelheim GmbH, Germany.
water solubility188 mg/LNot Available
logP2.12HENCZI,M ET AL. (1995)
Predicted Properties
PropertyValueSource
Water Solubility0.164 mg/mLALOGPS
logP2.14ALOGPS
logP2.55ChemAxon
logS-3.3ALOGPS
pKa (Strongest Acidic)4.07ChemAxon
pKa (Strongest Basic)-6.7ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area40.62 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity80.3 m3·mol-1ChemAxon
Polarizability30.07 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.99
Blood Brain Barrier+0.9904
Caco-2 permeable+0.7487
P-glycoprotein substrateNon-substrate0.5733
P-glycoprotein inhibitor INon-inhibitor0.5462
P-glycoprotein inhibitor IINon-inhibitor0.9204
Renal organic cation transporterNon-inhibitor0.7373
CYP450 2C9 substrateNon-substrate0.7058
CYP450 2D6 substrateNon-substrate0.8607
CYP450 3A4 substrateSubstrate0.6871
CYP450 1A2 substrateNon-inhibitor0.6829
CYP450 2C9 inhibitorNon-inhibitor0.5296
CYP450 2D6 inhibitorNon-inhibitor0.8908
CYP450 2C19 inhibitorNon-inhibitor0.5791
CYP450 3A4 inhibitorInhibitor0.7008
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.5308
Ames testNon AMES toxic0.9132
CarcinogenicityNon-carcinogens0.7846
BiodegradationNot ready biodegradable1.0
Rat acute toxicity1.7313 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9896
hERG inhibition (predictor II)Non-inhibitor0.8651
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Download (11.4 KB)
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Mass Spectrum (Electron Ionization)MSsplash10-0pb9-6392000000-a76f30f353b3407df0c6
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-0a4i-0090000000-3b46d60abcc8dfacf4d8
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-0udi-0019000000-71512d7a18cf60430dd9
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-0a4i-0092000000-e687a1e3760fb870dbc9
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-0a4i-0090000000-d450ded1f22039f00b63
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-0ab9-0190000000-e4211cbc2957a587e3d3
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-05fr-0590000000-51f4fa0445c2d047ef6b
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-0g4j-1960000000-a89e1c91bfa7b974be48
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-014j-4920000000-93c0877b3acf519d2b98
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-016u-7900000000-bc29714be08b6ae4120b
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-0hi6-9600000000-7c6a3974d95a0015757e

Taxonomy

Description
This compound belongs to the class of organic compounds known as benzodiazepines. These are organic compounds containing a benzene ring fused to either isomers of diazepine(unsaturated seven-member heterocycle with two nitrogen atoms replacing two carbon atoms).
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Benzodiazepines
Sub Class
Not Available
Direct Parent
Benzodiazepines
Alternative Parents
1,4-diazepines / Benzene and substituted derivatives / Aryl chlorides / 1,3-dicarbonyl compounds / Tertiary carboxylic acid amides / Lactams / Azacyclic compounds / Organopnictogen compounds / Organonitrogen compounds / Organochlorides
show 2 more
Substituents
Benzodiazepine / Para-diazepine / Aryl chloride / Aryl halide / Monocyclic benzene moiety / 1,3-dicarbonyl compound / Benzenoid / Tertiary carboxylic acid amide / Lactam / Carboxamide group
show 13 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
organochlorine compound, 1,4-benzodiazepinone (CHEBI:31413)

Targets

Kind
Protein group
Organism
Human
Pharmacological action
Yes
Actions
Positive allosteric modulator
General Function
Inhibitory extracellular ligand-gated ion channel activity
Specific Function
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine...

Components:
References
  1. Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. [PubMed:11752090]
  2. Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. doi: 10.1111/j.1600-0404.2008.01004.x. Epub 2008 Mar 31. [PubMed:18384456]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Steroid hydroxylase activity
Specific Function
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and im...
Gene Name
CYP2C19
Uniprot ID
P33261
Uniprot Name
Cytochrome P450 2C19
Molecular Weight
55930.545 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
Inducer
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2B6
Uniprot ID
P20813
Uniprot Name
Cytochrome P450 2B6
Molecular Weight
56277.81 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2C18
Uniprot ID
P33260
Uniprot Name
Cytochrome P450 2C18
Molecular Weight
55710.075 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Steroid hydroxylase activity
Specific Function
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic...
Gene Name
CYP2D6
Uniprot ID
P10635
Uniprot Name
Cytochrome P450 2D6
Molecular Weight
55768.94 Da

Transporters

Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Other
General Function
Neurotransmitter:sodium symporter activity
Specific Function
Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.
Gene Name
SLC6A1
Uniprot ID
P30531
Uniprot Name
Sodium- and chloride-dependent GABA transporter 1
Molecular Weight
67073.0 Da
References
  1. Giarratano M, Standley K, Benbadis SR: Clobazam for treatment of epilepsy. Expert Opin Pharmacother. 2012 Feb;13(2):227-33. doi: 10.1517/14656566.2012.647686. Epub 2012 Jan 13. [PubMed:22242724]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Other
General Function
Neurotransmitter:sodium symporter activity
Specific Function
Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.
Gene Name
SLC6A11
Uniprot ID
P48066
Uniprot Name
Sodium- and chloride-dependent GABA transporter 3
Molecular Weight
70605.145 Da
References
  1. Giarratano M, Standley K, Benbadis SR: Clobazam for treatment of epilepsy. Expert Opin Pharmacother. 2012 Feb;13(2):227-33. doi: 10.1517/14656566.2012.647686. Epub 2012 Jan 13. [PubMed:22242724]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Xenobiotic-transporting atpase activity
Specific Function
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name
ABCB1
Uniprot ID
P08183
Uniprot Name
Multidrug resistance protein 1
Molecular Weight
141477.255 Da

Drug created on June 13, 2005 07:24 / Updated on January 19, 2018 10:46