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Identification
NameClobazam
Accession NumberDB00349  (APRD00307)
TypeSmall Molecule
GroupsApproved, Illicit
DescriptionClobazam belongs to the 1,5-benzodiazepine class of drugs and is expected to have a better side-effect profile compared to older 1,4-benzodiazepines. It has been marketed as an anxiolytic since 1975 and an anticonvulsant since 1984. The oral preparation was FDA approved on October 21, 2011. An oral suspension is expected to be available in 2013.
Structure
Thumb
Synonyms
1-phenyl-5-methyl-8-chloro-1,2,4,5-tetrahydro-2,4-dioxo-3H-1,5-benzodiazepine
7-Chloro-1-methyl-5-phenyl-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione
Clobazam
Clobazamum
External Identifiers
  • H 4723
  • HR 376
  • LM 2717
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Clobazam-10Tablet10 mgOralPro Doc Limitee2003-12-09Not applicableCanada
Dom-clobazamTablet10 mgOralDominion Pharmacal2003-03-272016-10-25Canada
Frisium Tab 10mgTablet10 mgOralHoechst Canada Inc.1991-12-311996-08-29Canada
Frisium Tablet 10mgTablet10 mgOralLundbeck LLC1997-03-24Not applicableCanada
Frisium Tablets 10mgTablet10 mgOralHoechst Roussel Canada Inc.1994-12-311999-08-11Canada
Novo-clobazamTablet10 mgOralTeva Canada Limited1998-07-07Not applicableCanada
Ntp-clobazamTablet10 mgOralTeva Canada LimitedNot applicableNot applicableCanada
OnfiTablet5 mg/1OralLundbeck LLC2011-10-212016-02-28Us
OnfiTablet10 mg/1OralLundbeck LLC2013-12-10Not applicableUs
OnfiTablet10 mg/1OralLundbeck LLC2013-08-122016-04-30Us
OnfiTablet20 mg/1OralLundbeck LLC2013-12-10Not applicableUs
OnfiTablet20 mg/1OralLundbeck LLC2013-08-122016-06-30Us
OnfiSuspension2.5 mg/mLOralLundbeck LLC2012-12-14Not applicableUs
PMS-clobazamTablet10 mgOralPharmascience Inc2001-11-16Not applicableCanada
Ratio-clobazamTablet10 mgOralRatiopharm Inc Division Of Teva Canada Limited1998-11-302010-08-02Canada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-clobazam TabletsTablet10 mgOralApotex Inc2001-11-28Not applicableCanada
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
AedonSanofi-Aventis
CastiliumSanofi-Aventis
ClobamSquare
ClobamaxSherfarma
FrisiumSanofi-Aventis
GrifoclobamChile
MystanDainippon Sumitomo
NoiafrenSanofi Aventis
SederlonaNot Available
UrbanilSanofi-Aventis
UrbanolSanofi-Aventis
UrbanylSanofi-Aventis
VeniumHudson
Brand mixturesNot Available
SaltsNot Available
Categories
UNII2MRO291B4U
CAS number22316-47-8
WeightAverage: 300.74
Monoisotopic: 300.066555377
Chemical FormulaC16H13ClN2O2
InChI KeyCXOXHMZGEKVPMT-UHFFFAOYSA-N
InChI
InChI=1S/C16H13ClN2O2/c1-18-13-8-7-11(17)9-14(13)19(16(21)10-15(18)20)12-5-3-2-4-6-12/h2-9H,10H2,1H3
IUPAC Name
7-chloro-1-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-2,4-dione
SMILES
CN1C2=C(C=C(Cl)C=C2)N(C2=CC=CC=C2)C(=O)CC1=O
Pharmacology
IndicationFor treatment and management of epilepsy and seizures associated with Lennox-Gastaut syndrome, a difficult-to-treat form of childhood epilepsy.
Structured Indications
PharmacodynamicsSimilar to other benzodiazepines, clobazam binds to the interface of the α and γ2-subunit of the GABA-A receptor. However, it is considered a partial agonist to GABA-A receptors which sets clobazam apart from 1,4-benzodiazepines which are full agonist. The significance of this difference is that one may experience less sedation with clobazam than with other benzodiazepines. Unlike the endogenous GABA ligand, clobazam binds allosterically to the GABA receptor to increase the frequency of the chloride channel opening and membrane permeability to chloride ions. Pharmacodynamic tolerance has been demonstrated in animal models.
Mechanism of actionClobazam binds at distinct binding sites associated with the chloride ionopore at the post-synaptic GABA receptor. These GABA receptors are in various locations in the CNS (limbic, reticular formation) and clobazam increases the duration of time for which the chloride ionopore is open. As a result, hyper polarization and stabilization of the membrane occur as the post-synaptic inhibitory effect of GABA is enhanced.
TargetKindPharmacological actionActionsOrganismUniProt ID
GABA-A receptor (anion channel)Protein groupyes
positive allosteric modulator
Humannot applicabledetails
Related Articles
AbsorptionAfter oral administration of clobazam, it is almost completely absorbed (87% of dose). Bioavailability relative to solution was almost at 100%. Food does not affect absorption. Tmax = 1-3 hours.
Volume of distribution

Vdss = 100 L. This high volume of distribution suggests extensive distribution to body tissues.

Protein bindingClobazam is the primary circulating entity in the serum and is highly protein-bound (80-90%).
Metabolism

Clobazam is extensively metabolized in the liver via N-demethylation and hydroxylation. Clobazam has two major metabolites: N-desmethylclobazam (norclobazam) and 4'-hydroxyclobazam, the former of which is active. Norclobazam is one-fourth the potency of clobazam. The main enzyme that facilitates the process of N-demethylation is CYP3A4, and to a lesser extent by CYP2C19 and CYP2B6. Norclobazam itself is also metabolized via hydroxylation, primarily by CYP2C19. The formation of 4'-hydroxyclobazam is facilitated by CYP2C18 and CYP2C19. A factor in determining extent of metabolism is the genetic profile of the individual patient as CYP2C19 is a polymorphic enzyme.

SubstrateEnzymesProduct
Clobazam
norclobazamDetails
Clobazam
Not Available
4'-hydroxyclobazamDetails
Route of eliminationClobazam is eliminated via the urine (~94%) as metabolites.
Half lifeThe mean elimination half life of an oral dose of clobazam 40 mg is 32 hours. It's main metabolite, norclobazam, as a half life of 57 hours. The half life in adult patients with epilepsy are higher than those that are healthy.
Clearance

Median estimated clearance = 2.49 L/h

ToxicityThe most common adverse effects include somnolence, pyrexia, upper respiratory tract infection, and lethargy.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug Reactions
Interacting Gene/EnzymeSNP RS IDAllele nameDefining changeAdverse ReactionReference(s)
Cytochrome P450 2C19
Gene symbol: CYP2C19
UniProt: P33261
rs4244285 CYP2C19*2G > A/CClobazem is metabolized into N-desmethylclobazem (NCLB) mostly by CYP3A4. NCLB is primarily metabolized by 2C19. Those with one 2C19*2 allele mutation (1*/2*) are intermediate metabolizers of NCLB. Those with two (2*/2*) mutations will metabolize NCLB poorly in comparisone to extensive metabolizers (1*/1*). Levels of NCLB can be five times higher in poor metabolizers, and two times higher in intermediate metabolizers as compared to individuals who are extensive metabolizers. The safety and efficacy of clobazem may be affected by polymorphic expression of CYP2C19*2.15483195
Interactions
Drug Interactions
DrugInteractionDrug group
1,1,1,2 TetrafluoroethaneThe risk or severity of adverse effects can be increased when Clobazam is combined with 1,1,1,2 Tetrafluoroethane.Investigational
4-MethoxyamphetamineThe metabolism of 4-Methoxyamphetamine can be decreased when combined with Clobazam.Experimental, Illicit
7-NitroindazoleThe risk or severity of adverse effects can be increased when 7-Nitroindazole is combined with Clobazam.Experimental
AbirateroneThe metabolism of Clobazam can be decreased when combined with Abiraterone.Approved
AcepromazineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Clobazam.Approved, Vet Approved
AceprometazineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Clobazam.Approved
AcetaminophenThe serum concentration of Clobazam can be increased when it is combined with Acetaminophen.Approved
AcetylcholineThe metabolism of Acetylcholine can be decreased when combined with Clobazam.Approved
adipiplonThe risk or severity of adverse effects can be increased when adipiplon is combined with Clobazam.Investigational
AfatinibThe serum concentration of Clobazam can be increased when it is combined with Afatinib.Approved
AgomelatineThe risk or severity of adverse effects can be increased when Agomelatine is combined with Clobazam.Approved, Investigational
AjmalineThe metabolism of Ajmaline can be decreased when combined with Clobazam.Approved
AlbendazoleThe serum concentration of Clobazam can be increased when it is combined with Albendazole.Approved, Vet Approved
AldosteroneThe serum concentration of Clobazam can be decreased when it is combined with Aldosterone.Experimental
AlectinibThe serum concentration of Clobazam can be increased when it is combined with Alectinib.Approved
AlfaxaloneThe risk or severity of adverse effects can be increased when Alfaxalone is combined with Clobazam.Vet Approved
AlfentanilThe serum concentration of Clobazam can be increased when it is combined with Alfentanil.Approved, Illicit
AlmotriptanThe metabolism of Almotriptan can be decreased when combined with Clobazam.Approved, Investigational
AlogliptinThe metabolism of Alogliptin can be decreased when combined with Clobazam.Approved
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Alphacetylmethadol is combined with Clobazam.Experimental, Illicit
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Clobazam.Approved, Illicit, Investigational
AlprenololThe metabolism of Alprenolol can be decreased when combined with Clobazam.Approved, Withdrawn
AmantadineThe serum concentration of Clobazam can be increased when it is combined with Amantadine.Approved
Aminohippuric acidThe serum concentration of Clobazam can be increased when it is combined with Aminohippuric acid.Approved
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Clobazam.Approved, Withdrawn
AmiodaroneThe metabolism of Clobazam can be decreased when combined with Amiodarone.Approved, Investigational
AmisulprideThe risk or severity of adverse effects can be increased when Amisulpride is combined with Clobazam.Approved, Investigational
AmitriptylineThe serum concentration of Clobazam can be increased when it is combined with Amitriptyline.Approved
AmlodipineThe serum concentration of Clobazam can be increased when it is combined with Amlodipine.Approved
AmobarbitalThe risk or severity of adverse effects can be increased when Amobarbital is combined with Clobazam.Approved, Illicit
AmoxapineThe metabolism of Amoxapine can be decreased when combined with Clobazam.Approved
AmperozideThe risk or severity of adverse effects can be increased when Amperozide is combined with Clobazam.Experimental
AmphetamineThe metabolism of Amphetamine can be decreased when combined with Clobazam.Approved, Illicit
AmprenavirThe serum concentration of Clobazam can be decreased when it is combined with Amprenavir.Approved
AmsacrineThe serum concentration of Clobazam can be increased when it is combined with Amsacrine.Approved
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Clobazam.Approved
AprepitantThe serum concentration of Clobazam can be increased when it is combined with Aprepitant.Approved, Investigational
AprindineThe metabolism of Aprindine can be decreased when combined with Clobazam.Approved
ArformoterolThe metabolism of Arformoterol can be decreased when combined with Clobazam.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Clobazam.Approved, Investigational
ArmodafinilThe metabolism of Clobazam can be decreased when combined with Armodafinil.Approved, Investigational
ArtemetherThe metabolism of Artemether can be decreased when combined with Clobazam.Approved
ArticaineThe risk or severity of adverse effects can be increased when Articaine is combined with Clobazam.Approved
AsenapineThe risk or severity of adverse effects can be increased when Asenapine is combined with Clobazam.Approved
AstemizoleThe serum concentration of Clobazam can be increased when it is combined with Astemizole.Approved, Withdrawn
AtazanavirThe metabolism of Clobazam can be decreased when combined with Atazanavir.Approved, Investigational
AtenololThe serum concentration of Clobazam can be increased when it is combined with Atenolol.Approved
AtomoxetineThe metabolism of Clobazam can be decreased when combined with Atomoxetine.Approved
AtorvastatinThe serum concentration of Clobazam can be increased when it is combined with Atorvastatin.Approved
AzaperoneThe risk or severity of adverse effects can be increased when Azaperone is combined with Clobazam.Vet Approved
AzelastineClobazam may increase the central nervous system depressant (CNS depressant) activities of Azelastine.Approved
AzelastineThe serum concentration of Clobazam can be increased when it is combined with Azelastine.Approved
AzithromycinThe serum concentration of Clobazam can be increased when it is combined with Azithromycin.Approved
BaclofenThe risk or severity of adverse effects can be increased when Baclofen is combined with Clobazam.Approved
BarbitalThe risk or severity of adverse effects can be increased when Barbital is combined with Clobazam.Illicit
BenperidolThe risk or severity of adverse effects can be increased when Clobazam is combined with Benperidol.Investigational
BenzatropineThe metabolism of Benzatropine can be decreased when combined with Clobazam.Approved
BenzocaineThe serum concentration of Clobazam can be increased when it is combined with Benzocaine.Approved
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Clobazam.Approved
BepridilThe serum concentration of Clobazam can be increased when it is combined with Bepridil.Approved, Withdrawn
BetaxololThe metabolism of Betaxolol can be decreased when combined with Clobazam.Approved
BexaroteneThe serum concentration of Clobazam can be decreased when it is combined with Bexarotene.Approved, Investigational
BiperidenThe serum concentration of Clobazam can be increased when it is combined with Biperiden.Approved
BisoprololThe metabolism of Bisoprolol can be decreased when combined with Clobazam.Approved
BoceprevirThe metabolism of Clobazam can be decreased when combined with Boceprevir.Approved
BortezomibThe metabolism of Clobazam can be decreased when combined with Bortezomib.Approved, Investigational
BosentanThe serum concentration of Clobazam can be decreased when it is combined with Bosentan.Approved, Investigational
BosutinibThe serum concentration of Clobazam can be increased when it is combined with Bosutinib.Approved
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Clobazam.Approved
BrimonidineThe risk or severity of adverse effects can be increased when Clobazam is combined with Brimonidine.Approved
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Clobazam.Approved
BromazepamThe risk or severity of adverse effects can be increased when Bromazepam is combined with Clobazam.Approved, Illicit
BromocriptineThe serum concentration of Clobazam can be increased when it is combined with Bromocriptine.Approved, Investigational
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Clobazam.Approved
BrotizolamThe risk or severity of adverse effects can be increased when Brotizolam is combined with Clobazam.Approved, Withdrawn
BufuralolThe metabolism of Bufuralol can be decreased when combined with Clobazam.Experimental, Investigational
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Clobazam.Approved, Investigational
BuprenorphineClobazam may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BupropionThe metabolism of Bupropion can be decreased when combined with Clobazam.Approved
BuspironeThe serum concentration of Clobazam can be increased when it is combined with Buspirone.Approved, Investigational
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Clobazam.Approved, Illicit
ButacaineThe risk or severity of adverse effects can be increased when Butacaine is combined with Clobazam.Vet Approved
ButalbitalThe risk or severity of adverse effects can be increased when Butalbital is combined with Clobazam.Approved, Illicit
ButambenThe risk or severity of adverse effects can be increased when Butamben is combined with Clobazam.Approved
ButethalThe risk or severity of adverse effects can be increased when Butethal is combined with Clobazam.Approved, Illicit
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Clobazam.Approved, Illicit, Vet Approved
CabazitaxelThe serum concentration of Clobazam can be increased when it is combined with Cabazitaxel.Approved
CaffeineThe serum concentration of Clobazam can be increased when it is combined with Caffeine.Approved
CanagliflozinThe serum concentration of Clobazam can be increased when it is combined with Canagliflozin.Approved
CandesartanThe serum concentration of Clobazam can be increased when it is combined with Candesartan.Approved
CaptoprilThe serum concentration of Clobazam can be increased when it is combined with Captopril.Approved
CarbamazepineThe metabolism of Clobazam can be increased when combined with Carbamazepine.Approved, Investigational
CarbinoxamineThe risk or severity of adverse effects can be increased when Clobazam is combined with Carbinoxamine.Approved
CarfentanilThe risk or severity of adverse effects can be increased when Carfentanil is combined with Clobazam.Illicit, Vet Approved
CariprazineThe metabolism of Cariprazine can be decreased when combined with Clobazam.Approved
CarisoprodolThe risk or severity of adverse effects can be increased when Clobazam is combined with Carisoprodol.Approved
CarteololThe metabolism of Carteolol can be decreased when combined with Clobazam.Approved
CarvedilolThe serum concentration of Clobazam can be increased when it is combined with Carvedilol.Approved, Investigational
CaspofunginThe serum concentration of Clobazam can be increased when it is combined with Caspofungin.Approved
CephalexinThe metabolism of Cephalexin can be decreased when combined with Clobazam.Approved, Vet Approved
CeritinibThe serum concentration of Clobazam can be increased when it is combined with Ceritinib.Approved
CetirizineThe risk or severity of adverse effects can be increased when Cetirizine is combined with Clobazam.Approved
CevimelineThe metabolism of Cevimeline can be decreased when combined with Clobazam.Approved
Chloral hydrateThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Clobazam.Approved, Illicit, Vet Approved
ChloramphenicolThe metabolism of Clobazam can be decreased when combined with Chloramphenicol.Approved, Vet Approved
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Clobazam.Approved, Illicit
ChlormezanoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Clobazam.Approved, Withdrawn
ChloroprocaineThe risk or severity of adverse effects can be increased when Chloroprocaine is combined with Clobazam.Approved
ChloroquineThe serum concentration of Clobazam can be increased when it is combined with Chloroquine.Approved, Vet Approved
ChlorotrianiseneThe serum concentration of Chlorotrianisene can be decreased when it is combined with Clobazam.Withdrawn
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Clobazam.Approved
ChlorpromazineThe serum concentration of Clobazam can be increased when it is combined with Chlorpromazine.Approved, Vet Approved
ChlorpropamideThe serum concentration of Clobazam can be increased when it is combined with Chlorpropamide.Approved
ChlorprothixeneThe serum concentration of Clobazam can be increased when it is combined with Chlorprothixene.Approved, Withdrawn
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Clobazam.Approved
CholecalciferolThe metabolism of Clobazam can be decreased when combined with Cholecalciferol.Approved, Nutraceutical
CholesterolThe serum concentration of Clobazam can be increased when it is combined with Cholesterol.Experimental
Cholic AcidThe serum concentration of Clobazam can be decreased when it is combined with Cholic Acid.Approved
CilazaprilThe serum concentration of Clobazam can be increased when it is combined with Cilazapril.Approved
CilostazolThe metabolism of Cilostazol can be decreased when combined with Clobazam.Approved
CimetidineThe serum concentration of Clobazam can be decreased when it is combined with Cimetidine.Approved
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Clobazam.Approved, Vet Approved
CinnarizineThe metabolism of Cinnarizine can be decreased when combined with Clobazam.Approved
CiprofloxacinThe serum concentration of Clobazam can be increased when it is combined with Ciprofloxacin.Approved, Investigational
CitalopramThe serum concentration of Clobazam can be increased when it is combined with Citalopram.Approved
ClarithromycinThe metabolism of Clobazam can be decreased when combined with Clarithromycin.Approved
ClemastineThe metabolism of Clobazam can be decreased when combined with Clemastine.Approved
ClevidipineThe metabolism of Clevidipine can be decreased when combined with Clobazam.Approved
ClidiniumThe risk or severity of adverse effects can be increased when Clobazam is combined with Clidinium.Approved
ClofazimineThe serum concentration of Clobazam can be increased when it is combined with Clofazimine.Approved, Investigational
clomethiazoleThe risk or severity of adverse effects can be increased when clomethiazole is combined with Clobazam.Investigational
ClomipramineThe serum concentration of Clobazam can be increased when it is combined with Clomipramine.Approved, Vet Approved
ClonazepamThe risk or severity of adverse effects can be increased when Clobazam is combined with Clonazepam.Approved, Illicit
ClonidineThe metabolism of Clonidine can be decreased when combined with Clobazam.Approved
ClopidogrelThe metabolism of Clobazam can be decreased when combined with Clopidogrel.Approved, Nutraceutical
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Clobazam.Approved, Illicit
ClotrimazoleThe metabolism of Clobazam can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineThe metabolism of Clozapine can be decreased when combined with Clobazam.Approved
CobicistatThe metabolism of Clobazam can be decreased when combined with Cobicistat.Approved
CocaineThe risk or severity of adverse effects can be increased when Cocaine is combined with Clobazam.Approved, Illicit
CodeineThe therapeutic efficacy of Codeine can be decreased when used in combination with Clobazam.Approved, Illicit
ColchicineThe serum concentration of Clobazam can be increased when it is combined with Colchicine.Approved
ColforsinThe serum concentration of Clobazam can be increased when it is combined with Colforsin.Experimental
ConivaptanThe serum concentration of Clobazam can be increased when it is combined with Conivaptan.Approved, Investigational
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be decreased when it is combined with Clobazam.Approved
CrizotinibThe metabolism of Clobazam can be decreased when combined with Crizotinib.Approved
CyclizineThe risk or severity of adverse effects can be increased when Clobazam is combined with Cyclizine.Approved
CyclobenzaprineThe metabolism of Cyclobenzaprine can be decreased when combined with Clobazam.Approved
CyclophosphamideThe serum concentration of Clobazam can be increased when it is combined with Cyclophosphamide.Approved, Investigational
CyclosporineThe metabolism of Clobazam can be decreased when combined with Cyclosporine.Approved, Investigational, Vet Approved
CyproheptadineThe risk or severity of adverse effects can be increased when Clobazam is combined with Cyproheptadine.Approved
DabrafenibThe serum concentration of Clobazam can be decreased when it is combined with Dabrafenib.Approved
DaclatasvirThe serum concentration of Clobazam can be increased when it is combined with Daclatasvir.Approved
DactinomycinThe serum concentration of Clobazam can be increased when it is combined with Dactinomycin.Approved
DantroleneThe risk or severity of adverse effects can be increased when Clobazam is combined with Dantrolene.Approved
DapagliflozinThe metabolism of Dapagliflozin can be decreased when combined with Clobazam.Approved
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Clobazam.Approved
DapoxetineThe risk or severity of adverse effects can be increased when Clobazam is combined with Dapoxetine.Investigational
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Clobazam.Approved, Investigational
DarunavirThe metabolism of Clobazam can be decreased when combined with Darunavir.Approved
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Clobazam.Approved
DasatinibThe serum concentration of Clobazam can be increased when it is combined with Dasatinib.Approved, Investigational
DaunorubicinThe serum concentration of Clobazam can be decreased when it is combined with Daunorubicin.Approved
DebrisoquinThe metabolism of Debrisoquin can be decreased when combined with Clobazam.Approved
DeferasiroxThe serum concentration of Clobazam can be decreased when it is combined with Deferasirox.Approved, Investigational
DelavirdineThe metabolism of Clobazam can be decreased when combined with Delavirdine.Approved
deramciclaneThe risk or severity of adverse effects can be increased when deramciclane is combined with Clobazam.Investigational
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Clobazam.Approved
DesipramineThe serum concentration of Clobazam can be increased when it is combined with Desipramine.Approved
DesloratadineThe serum concentration of Clobazam can be increased when it is combined with Desloratadine.Approved, Investigational
DesogestrelThe serum concentration of Desogestrel can be decreased when it is combined with Clobazam.Approved
DesvenlafaxineThe risk or severity of adverse effects can be increased when Clobazam is combined with Desvenlafaxine.Approved
DetomidineThe risk or severity of adverse effects can be increased when Detomidine is combined with Clobazam.Vet Approved
DexamethasoneThe serum concentration of Clobazam can be decreased when it is combined with Dexamethasone.Approved, Investigational, Vet Approved
DexbrompheniramineThe risk or severity of adverse effects can be increased when Clobazam is combined with Dexbrompheniramine.Approved
DexfenfluramineThe metabolism of Dexfenfluramine can be decreased when combined with Clobazam.Approved, Illicit, Withdrawn
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Clobazam.Approved, Vet Approved
DexmethylphenidateThe metabolism of Dexmethylphenidate can be decreased when combined with Clobazam.Approved
DextroamphetamineThe metabolism of Dextroamphetamine can be decreased when combined with Clobazam.Approved, Illicit
DextromethorphanThe serum concentration of Clobazam can be increased when it is combined with Dextromethorphan.Approved
DextromoramideThe risk or severity of adverse effects can be increased when Dextromoramide is combined with Clobazam.Experimental, Illicit
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Clobazam.Approved, Illicit, Withdrawn
DezocineThe risk or severity of adverse effects can be increased when Dezocine is combined with Clobazam.Approved
DiazepamThe risk or severity of adverse effects can be increased when Diazepam is combined with Clobazam.Approved, Illicit, Vet Approved
DiclofenacThe serum concentration of Clobazam can be increased when it is combined with Diclofenac.Approved, Vet Approved
DienestrolThe serum concentration of Dienestrol can be decreased when it is combined with Clobazam.Approved
DienogestThe serum concentration of Dienogest can be decreased when it is combined with Clobazam.Approved
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be decreased when it is combined with Clobazam.Approved
DifenoxinThe risk or severity of adverse effects can be increased when Clobazam is combined with Difenoxin.Approved, Illicit
DigoxinThe serum concentration of Clobazam can be decreased when it is combined with Digoxin.Approved
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Clobazam.Approved, Illicit
DihydroergotamineThe metabolism of Clobazam can be decreased when combined with Dihydroergotamine.Approved
DihydroetorphineThe risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Clobazam.Experimental, Illicit
DihydromorphineThe risk or severity of adverse effects can be increased when Dihydromorphine is combined with Clobazam.Experimental, Illicit
DiltiazemThe metabolism of Clobazam can be decreased when combined with Diltiazem.Approved
DimenhydrinateThe risk or severity of adverse effects can be increased when Clobazam is combined with Dimenhydrinate.Approved
DiphenhydramineThe metabolism of Diphenhydramine can be decreased when combined with Clobazam.Approved
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Clobazam.Approved, Illicit
DipyridamoleThe serum concentration of Clobazam can be increased when it is combined with Dipyridamole.Approved
DolasetronThe metabolism of Dolasetron can be decreased when combined with Clobazam.Approved
DomperidoneThe metabolism of Domperidone can be decreased when combined with Clobazam.Approved, Investigational, Vet Approved
DonepezilThe metabolism of Donepezil can be decreased when combined with Clobazam.Approved
DopamineThe metabolism of Dopamine can be decreased when combined with Clobazam.Approved
DoramectinThe risk or severity of adverse effects can be increased when Doramectin is combined with Clobazam.Vet Approved
DoxazosinThe serum concentration of Clobazam can be increased when it is combined with Doxazosin.Approved
DoxepinThe serum concentration of Clobazam can be increased when it is combined with Doxepin.Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Clobazam.Approved, Investigational
DoxorubicinThe serum concentration of Clobazam can be decreased when it is combined with Doxorubicin.Approved, Investigational
DoxycyclineThe metabolism of Clobazam can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Clobazam.Approved, Vet Approved
DPDPEThe risk or severity of adverse effects can be increased when DPDPE is combined with Clobazam.Investigational
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Clobazam.Approved, Illicit
DronedaroneThe metabolism of Clobazam can be decreased when combined with Dronedarone.Approved
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Clobazam.Approved, Vet Approved
DrospirenoneThe serum concentration of Drospirenone can be decreased when it is combined with Clobazam.Approved
DrotebanolThe risk or severity of adverse effects can be increased when Drotebanol is combined with Clobazam.Experimental, Illicit
DuloxetineThe metabolism of Duloxetine can be decreased when combined with Clobazam.Approved
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Clobazam.Approved
EcgonineThe risk or severity of adverse effects can be increased when Ecgonine is combined with Clobazam.Experimental, Illicit
ECGONINE METHYL ESTERThe risk or severity of adverse effects can be increased when ECGONINE METHYL ESTER is combined with Clobazam.Experimental
EcopipamThe risk or severity of adverse effects can be increased when Clobazam is combined with Ecopipam.Investigational
EfavirenzThe serum concentration of Clobazam can be decreased when it is combined with Efavirenz.Approved, Investigational
ElbasvirThe serum concentration of Clobazam can be increased when it is combined with Elbasvir.Approved
EletriptanThe metabolism of Eletriptan can be decreased when combined with Clobazam.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Clobazam.Approved
EnalaprilThe serum concentration of Clobazam can be increased when it is combined with Enalapril.Approved, Vet Approved
EncainideThe metabolism of Encainide can be decreased when combined with Clobazam.Approved, Withdrawn
EnclomipheneThe metabolism of Enclomiphene can be decreased when combined with Clobazam.Investigational
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Clobazam.Approved, Vet Approved
EntacaponeThe risk or severity of adverse effects can be increased when Clobazam is combined with Entacapone.Approved, Investigational
EnzalutamideThe serum concentration of Clobazam can be decreased when it is combined with Enzalutamide.Approved
EpinastineThe metabolism of Epinastine can be decreased when combined with Clobazam.Approved, Investigational
ErgonovineThe serum concentration of Clobazam can be increased when it is combined with Ergonovine.Approved
ErgotamineThe serum concentration of Clobazam can be increased when it is combined with Ergotamine.Approved
ErlotinibThe metabolism of Erlotinib can be decreased when combined with Clobazam.Approved, Investigational
ErythromycinThe metabolism of Clobazam can be decreased when combined with Erythromycin.Approved, Vet Approved
EscitalopramThe metabolism of Escitalopram can be decreased when combined with Clobazam.Approved, Investigational
Eslicarbazepine acetateThe serum concentration of Clobazam can be decreased when it is combined with Eslicarbazepine acetate.Approved
EsmirtazapineThe metabolism of Esmirtazapine can be decreased when combined with Clobazam.Investigational
EsomeprazoleThe metabolism of Clobazam can be decreased when combined with Esomeprazole.Approved, Investigational
EstazolamThe risk or severity of adverse effects can be increased when Estazolam is combined with Clobazam.Approved, Illicit
EstradiolThe serum concentration of Estradiol can be decreased when it is combined with Clobazam.Approved, Investigational, Vet Approved
EstramustineThe serum concentration of Estramustine can be decreased when it is combined with Clobazam.Approved
EstriolThe serum concentration of Clobazam can be decreased when it is combined with Estriol.Approved, Vet Approved
Estrogens, esterifiedThe serum concentration of Estrogens, esterified can be decreased when it is combined with Clobazam.Approved
EstroneThe serum concentration of Clobazam can be decreased when it is combined with Estrone.Approved
Estrone sulfateThe serum concentration of Estrone sulfate can be decreased when it is combined with Clobazam.Approved
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Clobazam.Approved
EthanolEthanol may increase the central nervous system depressant (CNS depressant) activities of Clobazam.Approved
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Clobazam.Approved, Illicit, Withdrawn
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Clobazam.Approved
EthosuximideThe risk or severity of adverse effects can be increased when Clobazam is combined with Ethosuximide.Approved
EthotoinThe risk or severity of adverse effects can be increased when Clobazam is combined with Ethotoin.Approved
Ethyl carbamateThe risk or severity of adverse effects can be increased when Ethyl carbamate is combined with Clobazam.Withdrawn
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Ethyl loflazepate is combined with Clobazam.Approved, Illicit
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Clobazam.Approved, Illicit
Ethynodiol diacetateThe serum concentration of Ethynodiol diacetate can be decreased when it is combined with Clobazam.Approved
EtidocaineThe risk or severity of adverse effects can be increased when Etidocaine is combined with Clobazam.Approved
EtifoxineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Clobazam.Withdrawn
EtizolamThe risk or severity of adverse effects can be increased when Etizolam is combined with Clobazam.Approved
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Clobazam.Approved
EtonogestrelThe serum concentration of Etonogestrel can be decreased when it is combined with Clobazam.Approved, Investigational
EtoperidoneThe risk or severity of adverse effects can be increased when Clobazam is combined with Etoperidone.Approved
EtoposideThe serum concentration of Clobazam can be increased when it is combined with Etoposide.Approved
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Clobazam.Approved, Investigational
EtorphineThe risk or severity of adverse effects can be increased when Etorphine is combined with Clobazam.Illicit, Vet Approved
EtravirineThe serum concentration of Clobazam can be decreased when it is combined with Etravirine.Approved
EzogabineThe risk or severity of adverse effects can be increased when Clobazam is combined with Ezogabine.Approved
FelbamateThe risk or severity of adverse effects can be increased when Clobazam is combined with Felbamate.Approved
FelodipineThe serum concentration of Clobazam can be increased when it is combined with Felodipine.Approved, Investigational
FencamfamineThe risk or severity of adverse effects can be increased when Fencamfamine is combined with Clobazam.Approved, Illicit, Withdrawn
FentanylThe serum concentration of Clobazam can be increased when it is combined with Fentanyl.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Clobazam.Approved
FexofenadineThe serum concentration of Clobazam can be increased when it is combined with Fexofenadine.Approved
FidaxomicinThe serum concentration of Clobazam can be increased when it is combined with Fidaxomicin.Approved
FingolimodThe metabolism of Fingolimod can be decreased when combined with Clobazam.Approved, Investigational
FlecainideThe metabolism of Flecainide can be decreased when combined with Clobazam.Approved, Withdrawn
FlibanserinThe risk or severity of adverse effects can be increased when Clobazam is combined with Flibanserin.Approved
FluconazoleThe metabolism of Clobazam can be decreased when combined with Fluconazole.Approved
FludiazepamThe risk or severity of adverse effects can be increased when Fludiazepam is combined with Clobazam.Approved, Illicit
FlunarizineThe metabolism of Flunarizine can be decreased when combined with Clobazam.Approved
FlunitrazepamThe risk or severity of adverse effects can be increased when Flunitrazepam is combined with Clobazam.Approved, Illicit
FluoxetineThe serum concentration of Clobazam can be increased when it is combined with Fluoxetine.Approved, Vet Approved
FlupentixolThe serum concentration of Clobazam can be increased when it is combined with Flupentixol.Approved, Withdrawn
FluphenazineThe serum concentration of Clobazam can be increased when it is combined with Fluphenazine.Approved
FlurazepamThe serum concentration of Clobazam can be increased when it is combined with Flurazepam.Approved, Illicit
FluspirileneThe risk or severity of adverse effects can be increased when Fluspirilene is combined with Clobazam.Approved
Fluticasone PropionateThe risk or severity of adverse effects can be increased when Clobazam is combined with Fluticasone Propionate.Approved
FluvastatinThe metabolism of Fluvastatin can be decreased when combined with Clobazam.Approved
FluvoxamineThe metabolism of Clobazam can be decreased when combined with Fluvoxamine.Approved, Investigational
FormoterolThe metabolism of Formoterol can be decreased when combined with Clobazam.Approved, Investigational
FosamprenavirThe metabolism of Clobazam can be decreased when combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Clobazam can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinThe metabolism of Clobazam can be increased when combined with Fosphenytoin.Approved
FospropofolThe risk or severity of adverse effects can be increased when Fospropofol is combined with Clobazam.Approved, Illicit
Fusidic AcidThe serum concentration of Clobazam can be increased when it is combined with Fusidic Acid.Approved
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Clobazam.Approved, Investigational
gabapentin enacarbilThe risk or severity of adverse effects can be increased when Clobazam is combined with gabapentin enacarbil.Approved
GalantamineThe metabolism of Galantamine can be decreased when combined with Clobazam.Approved
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Clobazam.Approved, Illicit
GefitinibThe serum concentration of Clobazam can be increased when it is combined with Gefitinib.Approved, Investigational
GemfibrozilThe metabolism of Clobazam can be decreased when combined with Gemfibrozil.Approved
GenisteinThe serum concentration of Clobazam can be increased when it is combined with Genistein.Investigational
GepironeThe risk or severity of adverse effects can be increased when Clobazam is combined with Gepirone.Investigational
GestodeneThe serum concentration of Gestodene can be decreased when it is combined with Clobazam.Approved
GlutethimideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Clobazam.Approved, Illicit
GlyburideThe serum concentration of Clobazam can be increased when it is combined with Glyburide.Approved
GlycerolThe serum concentration of Clobazam can be increased when it is combined with Glycerol.Experimental
Gramicidin DThe serum concentration of Clobazam can be increased when it is combined with Gramicidin D.Approved
GranisetronThe metabolism of Granisetron can be decreased when combined with Clobazam.Approved, Investigational
GrepafloxacinThe serum concentration of Clobazam can be increased when it is combined with Grepafloxacin.Withdrawn
GuanfacineThe risk or severity of adverse effects can be increased when Clobazam is combined with Guanfacine.Approved, Investigational
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with Clobazam.Approved, Illicit, Withdrawn
HalofantrineThe metabolism of Halofantrine can be decreased when combined with Clobazam.Approved
HaloperidolThe serum concentration of Clobazam can be increased when it is combined with Haloperidol.Approved
HalothaneThe metabolism of Halothane can be decreased when combined with Clobazam.Approved, Vet Approved
HeroinThe risk or severity of adverse effects can be increased when Heroin is combined with Clobazam.Approved, Illicit
HexestrolThe serum concentration of Hexestrol can be decreased when it is combined with Clobazam.Withdrawn
HexobarbitalThe risk or severity of adverse effects can be increased when Hexobarbital is combined with Clobazam.Approved
HydrocodoneClobazam may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.Approved, Illicit
HydrocortisoneThe serum concentration of Clobazam can be increased when it is combined with Hydrocortisone.Approved, Vet Approved
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Clobazam.Approved, Illicit
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Clobazam.Approved
IbrutinibThe metabolism of Ibrutinib can be decreased when combined with Clobazam.Approved
IdarubicinThe metabolism of Idarubicin can be decreased when combined with Clobazam.Approved
IdelalisibThe serum concentration of Clobazam can be increased when it is combined with Idelalisib.Approved
IloperidoneThe metabolism of Iloperidone can be decreased when combined with Clobazam.Approved
ImatinibThe metabolism of Clobazam can be decreased when combined with Imatinib.Approved
ImipramineThe serum concentration of Clobazam can be increased when it is combined with Imipramine.Approved
IndalpineThe risk or severity of adverse effects can be increased when Clobazam is combined with Indalpine.Investigational, Withdrawn
IndinavirThe metabolism of Clobazam can be decreased when combined with Indinavir.Approved
IndomethacinThe serum concentration of Clobazam can be increased when it is combined with Indomethacin.Approved, Investigational
Ipratropium bromideThe metabolism of Ipratropium bromide can be decreased when combined with Clobazam.Approved
IsavuconazoniumThe metabolism of Clobazam can be decreased when combined with Isavuconazonium.Approved, Investigational
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Clobazam.Approved, Vet Approved
IsoniazidThe metabolism of Clobazam can be decreased when combined with Isoniazid.Approved
IsradipineThe metabolism of Clobazam can be decreased when combined with Isradipine.Approved
ItraconazoleThe metabolism of Clobazam can be decreased when combined with Itraconazole.Approved, Investigational
IvacaftorThe serum concentration of Clobazam can be increased when it is combined with Ivacaftor.Approved
IvermectinThe serum concentration of Clobazam can be increased when it is combined with Ivermectin.Approved, Vet Approved
IxazomibThe metabolism of Ixazomib can be decreased when combined with Clobazam.Approved
KetamineThe serum concentration of Clobazam can be increased when it is combined with Ketamine.Approved, Vet Approved
KetazolamThe risk or severity of adverse effects can be increased when Ketazolam is combined with Clobazam.Approved
KetobemidoneThe risk or severity of adverse effects can be increased when Ketobemidone is combined with Clobazam.Approved
KetoconazoleThe metabolism of Clobazam can be decreased when combined with Ketoconazole.Approved, Investigational
LabetalolThe metabolism of Labetalol can be decreased when combined with Clobazam.Approved
LamotrigineThe risk or severity of adverse effects can be increased when Clobazam is combined with Lamotrigine.Approved, Investigational
LansoprazoleThe serum concentration of Clobazam can be increased when it is combined with Lansoprazole.Approved, Investigational
LapatinibThe serum concentration of Clobazam can be increased when it is combined with Lapatinib.Approved, Investigational
LevetiracetamThe risk or severity of adverse effects can be increased when Clobazam is combined with Levetiracetam.Approved, Investigational
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Clobazam.Approved
LevocabastineThe risk or severity of adverse effects can be increased when Clobazam is combined with Levocabastine.Approved
LevocetirizineThe risk or severity of adverse effects can be increased when Clobazam is combined with Levocetirizine.Approved
LevodopaThe metabolism of Levodopa can be decreased when combined with Clobazam.Approved
LevofloxacinThe serum concentration of Clobazam can be increased when it is combined with Levofloxacin.Approved, Investigational
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Clobazam.Approved
LevomilnacipranThe metabolism of Levomilnacipran can be decreased when combined with Clobazam.Approved
LevonorgestrelThe serum concentration of Levonorgestrel can be decreased when it is combined with Clobazam.Approved, Investigational
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Clobazam.Approved
LevothyroxineThe serum concentration of Clobazam can be decreased when it is combined with Levothyroxine.Approved
LidocaineThe serum concentration of Clobazam can be increased when it is combined with Lidocaine.Approved, Vet Approved
LiothyronineThe serum concentration of Clobazam can be decreased when it is combined with Liothyronine.Approved, Vet Approved
LiotrixThe serum concentration of Clobazam can be decreased when it is combined with Liotrix.Approved
LisinoprilThe serum concentration of Clobazam can be increased when it is combined with Lisinopril.Approved, Investigational
LisurideThe metabolism of Lisuride can be decreased when combined with Clobazam.Approved
LithiumThe risk or severity of adverse effects can be increased when Lithium is combined with Clobazam.Approved
LofentanilThe risk or severity of adverse effects can be increased when Lofentanil is combined with Clobazam.Illicit
LomitapideThe serum concentration of Clobazam can be increased when it is combined with Lomitapide.Approved
LomustineThe metabolism of Lomustine can be decreased when combined with Clobazam.Approved
LoperamideThe serum concentration of Clobazam can be increased when it is combined with Loperamide.Approved
LopinavirThe metabolism of Clobazam can be decreased when combined with Lopinavir.Approved
LoratadineThe serum concentration of Clobazam can be increased when it is combined with Loratadine.Approved
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Clobazam.Approved
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Clobazam.Approved
LosartanThe serum concentration of Clobazam can be increased when it is combined with Losartan.Approved
LovastatinThe metabolism of Clobazam can be decreased when combined with Lovastatin.Approved, Investigational
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Clobazam.Approved
Lu AA21004The risk or severity of adverse effects can be increased when Lu AA21004 is combined with Clobazam.Investigational
LuliconazoleThe serum concentration of Clobazam can be increased when it is combined with Luliconazole.Approved
LumacaftorThe serum concentration of Clobazam can be decreased when it is combined with Lumacaftor.Approved
LurasidoneThe risk or severity of adverse effects can be increased when Lurasidone is combined with Clobazam.Approved
LynestrenolThe serum concentration of Lynestrenol can be decreased when it is combined with Clobazam.Investigational
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Clobazam.Approved, Vet Approved
MaprotilineThe serum concentration of Clobazam can be increased when it is combined with Maprotiline.Approved
MebendazoleThe serum concentration of Clobazam can be increased when it is combined with Mebendazole.Approved, Vet Approved
MeclizineThe risk or severity of adverse effects can be increased when Clobazam is combined with Meclizine.Approved
MedetomidineThe risk or severity of adverse effects can be increased when Medetomidine is combined with Clobazam.Vet Approved
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with Clobazam.Approved, Investigational
MefloquineThe therapeutic efficacy of Clobazam can be decreased when used in combination with Mefloquine.Approved
Megestrol acetateThe serum concentration of Clobazam can be increased when it is combined with Megestrol acetate.Approved, Vet Approved
MelatoninThe risk or severity of adverse effects can be increased when Melatonin is combined with Clobazam.Approved, Nutraceutical, Vet Approved
MelperoneThe risk or severity of adverse effects can be increased when Melperone is combined with Clobazam.Approved
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Clobazam.Investigational, Withdrawn
MepivacaineThe risk or severity of adverse effects can be increased when Mepivacaine is combined with Clobazam.Approved, Vet Approved
MeprobamateThe serum concentration of Clobazam can be increased when it is combined with Meprobamate.Approved, Illicit
MequitazineThe metabolism of Mequitazine can be decreased when combined with Clobazam.Approved
MesoridazineThe metabolism of Mesoridazine can be decreased when combined with Clobazam.Approved
MestranolThe serum concentration of Mestranol can be decreased when it is combined with Clobazam.Approved
MetaxaloneThe risk or severity of adverse effects can be increased when Clobazam is combined with Metaxalone.Approved
MethadoneThe serum concentration of Clobazam can be increased when it is combined with Methadone.Approved
Methadyl AcetateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Clobazam.Approved, Illicit
MethallenestrilThe serum concentration of Methallenestril can be decreased when it is combined with Clobazam.Experimental
MethamphetamineThe metabolism of Methamphetamine can be decreased when combined with Clobazam.Approved, Illicit
MethapyrileneThe risk or severity of adverse effects can be increased when Methapyrilene is combined with Clobazam.Withdrawn
MethaqualoneThe risk or severity of adverse effects can be increased when Methaqualone is combined with Clobazam.Illicit, Withdrawn
MethocarbamolThe risk or severity of adverse effects can be increased when Clobazam is combined with Methocarbamol.Approved, Vet Approved
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Clobazam.Approved
MethotrimeprazineClobazam may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.Approved
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Clobazam.Approved, Vet Approved
MethsuximideThe risk or severity of adverse effects can be increased when Clobazam is combined with Methsuximide.Approved
MethylphenidateThe metabolism of Methylphenidate can be decreased when combined with Clobazam.Approved, Investigational
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Clobazam.Approved
MethyprylonThe metabolism of Methyprylon can be decreased when combined with Clobazam.Approved, Illicit, Withdrawn
MetoclopramideThe metabolism of Metoclopramide can be decreased when combined with Clobazam.Approved, Investigational
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Clobazam.Approved, Investigational
MetyrosineClobazam may increase the sedative activities of Metyrosine.Approved
MexiletineThe metabolism of Mexiletine can be decreased when combined with Clobazam.Approved
MianserinThe therapeutic efficacy of Clobazam can be decreased when used in combination with Mianserin.Approved
MibefradilThe serum concentration of Clobazam can be increased when it is combined with Mibefradil.Withdrawn
MiconazoleThe serum concentration of Clobazam can be increased when it is combined with Miconazole.Approved, Investigational, Vet Approved
MidazolamThe serum concentration of Clobazam can be decreased when it is combined with Midazolam.Approved, Illicit
MifepristoneThe serum concentration of Clobazam can be increased when it is combined with Mifepristone.Approved, Investigational
MilnacipranThe risk or severity of adverse effects can be increased when Clobazam is combined with Milnacipran.Approved
MinaprineThe metabolism of Minaprine can be decreased when combined with Clobazam.Approved
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Clobazam.Approved, Investigational
MirabegronThe metabolism of Mirabegron can be decreased when combined with Clobazam.Approved
MirtazapineClobazam may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.Approved
MitomycinThe serum concentration of Clobazam can be increased when it is combined with Mitomycin.Approved
MitotaneThe serum concentration of Clobazam can be decreased when it is combined with Mitotane.Approved
MitoxantroneThe serum concentration of Clobazam can be decreased when it is combined with Mitoxantrone.Approved, Investigational
MoclobemideThe metabolism of Moclobemide can be decreased when combined with Clobazam.Approved
ModafinilThe serum concentration of Clobazam can be decreased when it is combined with Modafinil.Approved, Investigational
MolindoneThe risk or severity of adverse effects can be increased when Molindone is combined with Clobazam.Approved
MorphineThe serum concentration of Clobazam can be increased when it is combined with Morphine.Approved, Investigational
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Clobazam.Approved, Investigational
NafcillinThe serum concentration of Clobazam can be decreased when it is combined with Nafcillin.Approved
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Clobazam.Approved
NaltrexoneThe serum concentration of Clobazam can be increased when it is combined with Naltrexone.Approved, Investigational, Vet Approved
NaringeninThe serum concentration of Clobazam can be increased when it is combined with Naringenin.Experimental
NateglinideThe metabolism of Nateglinide can be decreased when combined with Clobazam.Approved, Investigational
NebivololThe serum concentration of Nebivolol can be increased when it is combined with Clobazam.Approved, Investigational
NefazodoneThe metabolism of Clobazam can be decreased when combined with Nefazodone.Approved, Withdrawn
NelfinavirThe metabolism of Clobazam can be decreased when combined with Nelfinavir.Approved
NeostigmineThe serum concentration of Clobazam can be increased when it is combined with Neostigmine.Approved, Vet Approved
NetupitantThe serum concentration of Clobazam can be increased when it is combined with Netupitant.Approved
NevirapineThe metabolism of Clobazam can be increased when combined with Nevirapine.Approved
NicardipineThe serum concentration of Clobazam can be increased when it is combined with Nicardipine.Approved
NicergolineThe metabolism of Nicergoline can be decreased when combined with Clobazam.Approved
NicotineThe metabolism of Nicotine can be decreased when combined with Clobazam.Approved
NifedipineThe serum concentration of Clobazam can be decreased when it is combined with Nifedipine.Approved
NilotinibThe metabolism of Clobazam can be decreased when combined with Nilotinib.Approved, Investigational
NimodipineThe serum concentration of Nimodipine can be decreased when it is combined with Clobazam.Approved
NisoldipineThe serum concentration of Clobazam can be increased when it is combined with Nisoldipine.Approved
NitrazepamThe serum concentration of Clobazam can be increased when it is combined with Nitrazepam.Approved
NitrendipineThe serum concentration of Clobazam can be increased when it is combined with Nitrendipine.Approved
NitrofuralThe metabolism of Nitrofural can be decreased when combined with Clobazam.Approved, Vet Approved
Nitrous oxideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Clobazam.Approved, Vet Approved
NorelgestrominThe serum concentration of Norelgestromin can be decreased when it is combined with Clobazam.Approved
NorethisteroneThe serum concentration of Clobazam can be decreased when it is combined with Norethisterone.Approved
NorgestimateThe serum concentration of Norgestimate can be decreased when it is combined with Clobazam.Approved
NorgestrelThe serum concentration of Norgestrel can be decreased when it is combined with Clobazam.Approved
NormethadoneThe risk or severity of adverse effects can be increased when Normethadone is combined with Clobazam.Approved, Illicit
NortriptylineThe metabolism of Nortriptyline can be decreased when combined with Clobazam.Approved
OlanzapineThe metabolism of Olanzapine can be decreased when combined with Clobazam.Approved, Investigational
OlaparibThe metabolism of Clobazam can be decreased when combined with Olaparib.Approved
OlopatadineThe risk or severity of adverse effects can be increased when Clobazam is combined with Olopatadine.Approved
OmeprazoleThe serum concentration of Clobazam can be increased when it is combined with Omeprazole.Approved, Investigational, Vet Approved
OndansetronThe metabolism of Ondansetron can be decreased when combined with Clobazam.Approved
OpiumThe risk or severity of adverse effects can be increased when Opium is combined with Clobazam.Approved, Illicit
OrlistatThe serum concentration of Clobazam can be decreased when it is combined with Orlistat.Approved, Investigational
OrphenadrineClobazam may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.Approved
OsanetantThe risk or severity of adverse effects can be increased when Osanetant is combined with Clobazam.Investigational
OsimertinibThe serum concentration of Clobazam can be increased when it is combined with Osimertinib.Approved
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with Clobazam.Approved
OxetacaineThe risk or severity of adverse effects can be increased when Clobazam is combined with Oxetacaine.Investigational
OxprenololThe risk or severity of adverse effects can be increased when Oxprenolol is combined with Clobazam.Approved
OxybuprocaineThe risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Clobazam.Approved
OxycodoneThe metabolism of Oxycodone can be decreased when combined with Clobazam.Approved, Illicit, Investigational
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Clobazam.Approved, Investigational, Vet Approved
P-NitrophenolThe serum concentration of Clobazam can be increased when it is combined with P-Nitrophenol.Experimental
PaclitaxelThe serum concentration of Clobazam can be increased when it is combined with Paclitaxel.Approved, Vet Approved
PalbociclibThe serum concentration of Clobazam can be increased when it is combined with Palbociclib.Approved
PaliperidoneThe risk or severity of adverse effects can be increased when Paliperidone is combined with Clobazam.Approved
Palmitic AcidThe serum concentration of Clobazam can be increased when it is combined with Palmitic Acid.Experimental
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Clobazam.Approved, Investigational
PantoprazoleThe serum concentration of Clobazam can be increased when it is combined with Pantoprazole.Approved
ParaldehydeClobazam may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
ParoxetineThe serum concentration of Clobazam can be increased when it is combined with Paroxetine.Approved, Investigational
PazopanibThe metabolism of Pazopanib can be decreased when combined with Clobazam.Approved
PentamidineThe metabolism of Pentamidine can be decreased when combined with Clobazam.Approved
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Clobazam.Approved, Vet Approved
PentobarbitalThe metabolism of Clobazam can be increased when combined with Pentobarbital.Approved, Vet Approved
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Clobazam.Approved
PerazineThe risk or severity of adverse effects can be increased when Clobazam is combined with Perazine.Investigational
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Clobazam.Approved
PerindoprilThe serum concentration of Clobazam can be increased when it is combined with Perindopril.Approved
PerospironeThe risk or severity of adverse effects can be increased when Perospirone is combined with Clobazam.Approved
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Clobazam.Approved
PethidineThe metabolism of Pethidine can be decreased when combined with Clobazam.Approved
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Clobazam.Withdrawn
PhenforminThe metabolism of Phenformin can be decreased when combined with Clobazam.Approved, Withdrawn
PhenobarbitalThe metabolism of Clobazam can be increased when combined with Phenobarbital.Approved
PhenoxyethanolThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Clobazam.Approved
PhenytoinThe metabolism of Clobazam can be increased when combined with Phenytoin.Approved, Vet Approved
PimozideThe serum concentration of Clobazam can be increased when it is combined with Pimozide.Approved
PindololThe metabolism of Pindolol can be decreased when combined with Clobazam.Approved
PipamperoneThe risk or severity of adverse effects can be increased when Pipamperone is combined with Clobazam.Approved
PiperazineThe metabolism of Piperazine can be decreased when combined with Clobazam.Approved, Vet Approved
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Clobazam.Approved
PiritramideThe risk or severity of adverse effects can be increased when Clobazam is combined with Piritramide.Investigational
PizotifenThe risk or severity of adverse effects can be increased when Clobazam is combined with Pizotifen.Approved
Platelet Activating FactorThe serum concentration of Clobazam can be decreased when it is combined with Platelet Activating Factor.Experimental
PomalidomideThe risk or severity of adverse effects can be increased when Clobazam is combined with Pomalidomide.Approved
PonatinibThe serum concentration of Clobazam can be increased when it is combined with Ponatinib.Approved
PosaconazoleThe metabolism of Clobazam can be decreased when combined with Posaconazole.Approved, Investigational, Vet Approved
PramipexoleClobazam may increase the sedative activities of Pramipexole.Approved, Investigational
PramocaineThe risk or severity of adverse effects can be increased when Pramocaine is combined with Clobazam.Approved
PravastatinThe serum concentration of Clobazam can be increased when it is combined with Pravastatin.Approved
PrazepamThe risk or severity of adverse effects can be increased when Prazepam is combined with Clobazam.Approved, Illicit
PrazosinThe serum concentration of Clobazam can be increased when it is combined with Prazosin.Approved
PrednisoneThe serum concentration of Clobazam can be increased when it is combined with Prednisone.Approved, Vet Approved
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Clobazam.Approved, Illicit, Investigational
PregnanoloneThe risk or severity of adverse effects can be increased when Clobazam is combined with Pregnanolone.Investigational
PrilocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Clobazam.Approved
PrimidoneThe metabolism of Clobazam can be increased when combined with Primidone.Approved, Vet Approved
ProbenecidThe serum concentration of Clobazam can be increased when it is combined with Probenecid.Approved
ProcainamideThe metabolism of Procainamide can be decreased when combined with Clobazam.Approved
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with Clobazam.Approved, Investigational, Vet Approved
ProchlorperazineThe metabolism of Prochlorperazine can be decreased when combined with Clobazam.Approved, Vet Approved
ProgesteroneThe serum concentration of Clobazam can be decreased when it is combined with Progesterone.Approved, Vet Approved
PromazineThe risk or severity of adverse effects can be increased when Promazine is combined with Clobazam.Approved, Vet Approved
PromethazineThe serum concentration of Clobazam can be increased when it is combined with Promethazine.Approved
PropafenoneThe serum concentration of Clobazam can be increased when it is combined with Propafenone.Approved
ProparacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Clobazam.Approved, Vet Approved
PropofolThe metabolism of Propofol can be decreased when combined with Clobazam.Approved, Investigational, Vet Approved
PropoxycaineThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Clobazam.Approved
PropranololThe serum concentration of Clobazam can be increased when it is combined with Propranolol.Approved, Investigational
ProtriptylineThe serum concentration of Clobazam can be increased when it is combined with Protriptyline.Approved
PSD502The risk or severity of adverse effects can be increased when PSD502 is combined with Clobazam.Investigational
PseudoephedrineThe metabolism of Pseudoephedrine can be decreased when combined with Clobazam.Approved
QuazepamThe serum concentration of Clobazam can be increased when it is combined with Quazepam.Approved, Illicit
QuercetinThe serum concentration of Clobazam can be increased when it is combined with Quercetin.Experimental
QuetiapineThe metabolism of Quetiapine can be decreased when combined with Clobazam.Approved
QuinacrineThe serum concentration of Clobazam can be increased when it is combined with Quinacrine.Approved
QuinidineThe serum concentration of Clobazam can be increased when it is combined with Quinidine.Approved
QuinineThe serum concentration of Clobazam can be increased when it is combined with Quinine.Approved
RacloprideThe risk or severity of adverse effects can be increased when Clobazam is combined with Raclopride.Investigational
RamelteonThe risk or severity of adverse effects can be increased when Clobazam is combined with Ramelteon.Approved, Investigational
RanitidineThe serum concentration of Clobazam can be increased when it is combined with Ranitidine.Approved
RanolazineThe serum concentration of Clobazam can be increased when it is combined with Ranolazine.Approved, Investigational
ReboxetineThe serum concentration of Clobazam can be increased when it is combined with Reboxetine.Approved, Investigational
RegorafenibThe serum concentration of Clobazam can be increased when it is combined with Regorafenib.Approved
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Clobazam.Approved
RemoxiprideThe metabolism of Remoxipride can be decreased when combined with Clobazam.Approved, Withdrawn
repinotanThe metabolism of repinotan can be decreased when combined with Clobazam.Investigational
ReserpineThe serum concentration of Clobazam can be decreased when it is combined with Reserpine.Approved
RifabutinThe metabolism of Clobazam can be increased when combined with Rifabutin.Approved
RifampicinThe metabolism of Clobazam can be increased when combined with Rifampicin.Approved
RifapentineThe metabolism of Clobazam can be increased when combined with Rifapentine.Approved
RilpivirineThe serum concentration of Clobazam can be increased when it is combined with Rilpivirine.Approved
RisperidoneThe metabolism of Risperidone can be decreased when combined with Clobazam.Approved, Investigational
RitanserinThe risk or severity of adverse effects can be increased when Clobazam is combined with Ritanserin.Investigational
RitonavirThe metabolism of Clobazam can be decreased when combined with Ritonavir.Approved, Investigational
RolapitantThe serum concentration of Clobazam can be increased when it is combined with Rolapitant.Approved
RomifidineThe risk or severity of adverse effects can be increased when Romifidine is combined with Clobazam.Vet Approved
RopiniroleClobazam may increase the sedative activities of Ropinirole.Approved, Investigational
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Clobazam.Approved
RotigotineClobazam may increase the sedative activities of Rotigotine.Approved
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Clobazam.Approved
S-EthylisothioureaThe risk or severity of adverse effects can be increased when S-Ethylisothiourea is combined with Clobazam.Experimental
Sage 547The risk or severity of adverse effects can be increased when Clobazam is combined with Sage 547.Investigational
SaquinavirThe metabolism of Clobazam can be decreased when combined with Saquinavir.Approved, Investigational
ScopolamineThe serum concentration of Clobazam can be increased when it is combined with Scopolamine.Approved
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Clobazam.Approved, Vet Approved
SelegilineThe serum concentration of Clobazam can be increased when it is combined with Selegiline.Approved, Investigational, Vet Approved
SertindoleThe metabolism of Sertindole can be decreased when combined with Clobazam.Approved, Withdrawn
SertralineThe serum concentration of Clobazam can be increased when it is combined with Sertraline.Approved
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Clobazam.Approved, Vet Approved
SildenafilThe metabolism of Clobazam can be decreased when combined with Sildenafil.Approved, Investigational
SiltuximabThe serum concentration of Clobazam can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Clobazam can be increased when it is combined with Simeprevir.Approved
SimvastatinThe serum concentration of Clobazam can be increased when it is combined with Simvastatin.Approved
SirolimusThe serum concentration of Clobazam can be decreased when it is combined with Sirolimus.Approved, Investigational
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Clobazam.Approved
SorafenibThe serum concentration of Clobazam can be increased when it is combined with Sorafenib.Approved, Investigational
SparteineThe metabolism of Sparteine can be decreased when combined with Clobazam.Experimental
SpironolactoneThe serum concentration of Clobazam can be increased when it is combined with Spironolactone.Approved
St. John's WortThe serum concentration of Clobazam can be decreased when it is combined with St. John's Wort.Nutraceutical
StaurosporineThe serum concentration of Clobazam can be increased when it is combined with Staurosporine.Experimental
StiripentolThe serum concentration of Stiripentol can be increased when it is combined with Clobazam.Approved
StreptozocinThe serum concentration of Clobazam can be decreased when it is combined with Streptozocin.Approved
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Clobazam.Approved, Investigational
SulfinpyrazoneThe serum concentration of Clobazam can be increased when it is combined with Sulfinpyrazone.Approved
SulfisoxazoleThe metabolism of Clobazam can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Clobazam.Approved
SumatriptanThe serum concentration of Clobazam can be increased when it is combined with Sumatriptan.Approved, Investigational
SunitinibThe serum concentration of Clobazam can be increased when it is combined with Sunitinib.Approved, Investigational
SuvorexantClobazam may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.Approved
Synthetic Conjugated Estrogens, AThe serum concentration of Synthetic Conjugated Estrogens, A can be decreased when it is combined with Clobazam.Approved
TacrineThe serum concentration of Clobazam can be increased when it is combined with Tacrine.Withdrawn
TacrolimusThe serum concentration of Clobazam can be decreased when it is combined with Tacrolimus.Approved, Investigational
TamoxifenThe serum concentration of the active metabolites of Tamoxifen can be reduced when Tamoxifen is used in combination with Clobazam resulting in a loss in efficacy.Approved
TamsulosinThe metabolism of Tamsulosin can be decreased when combined with Clobazam.Approved, Investigational
TandospironeThe risk or severity of adverse effects can be increased when Clobazam is combined with Tandospirone.Investigational
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Clobazam.Approved
TasimelteonThe risk or severity of adverse effects can be increased when Clobazam is combined with Tasimelteon.Approved
Taurocholic AcidThe serum concentration of Clobazam can be increased when it is combined with Taurocholic Acid.Experimental
TegaserodThe metabolism of Tegaserod can be decreased when combined with Clobazam.Investigational, Withdrawn
TelaprevirThe metabolism of Clobazam can be decreased when combined with Telaprevir.Approved
TelithromycinThe metabolism of Clobazam can be decreased when combined with Telithromycin.Approved
TelmisartanThe serum concentration of Clobazam can be increased when it is combined with Telmisartan.Approved, Investigational
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Clobazam.Approved
TemsirolimusThe serum concentration of Clobazam can be increased when it is combined with Temsirolimus.Approved
TerazosinThe serum concentration of Clobazam can be increased when it is combined with Terazosin.Approved
TerfenadineThe serum concentration of Clobazam can be increased when it is combined with Terfenadine.Withdrawn
TesmilifeneThe serum concentration of Clobazam can be decreased when it is combined with Tesmilifene.Investigational
TestosteroneThe serum concentration of Clobazam can be increased when it is combined with Testosterone.Approved, Investigational
TetrabenazineThe metabolism of Tetrabenazine can be decreased when combined with Clobazam.Approved
TetracaineThe risk or severity of adverse effects can be increased when Tetracaine is combined with Clobazam.Approved, Vet Approved
TetrodotoxinThe risk or severity of adverse effects can be increased when Tetrodotoxin is combined with Clobazam.Investigational
ThalidomideClobazam may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.Approved, Investigational, Withdrawn
TheophyllineThe metabolism of Theophylline can be decreased when combined with Clobazam.Approved
ThiamylalThe risk or severity of adverse effects can be increased when Thiamylal is combined with Clobazam.Approved, Vet Approved
ThiopentalThe risk or severity of adverse effects can be increased when Thiopental is combined with Clobazam.Approved, Vet Approved
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Clobazam.Approved
ThiotepaThe metabolism of Clobazam can be decreased when combined with Thiotepa.Approved
ThiothixeneThe risk or severity of adverse effects can be increased when Thiothixene is combined with Clobazam.Approved
TiagabineThe risk or severity of adverse effects can be increased when Clobazam is combined with Tiagabine.Approved
TiaprideThe risk or severity of adverse effects can be increased when Clobazam is combined with Tiapride.Investigational
TicagrelorThe serum concentration of Clobazam can be increased when it is combined with Ticagrelor.Approved
TiclopidineThe metabolism of Clobazam can be decreased when combined with Ticlopidine.Approved
TiletamineThe risk or severity of adverse effects can be increased when Tiletamine is combined with Clobazam.Vet Approved
TimololThe metabolism of Timolol can be decreased when combined with Clobazam.Approved
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Clobazam.Approved
TipranavirThe metabolism of Tipranavir can be decreased when combined with Clobazam.Approved, Investigational
TizanidineThe risk or severity of adverse effects can be increased when Clobazam is combined with Tizanidine.Approved
TocilizumabThe serum concentration of Clobazam can be decreased when it is combined with Tocilizumab.Approved
TolcaponeThe risk or severity of adverse effects can be increased when Tolcapone is combined with Clobazam.Approved, Withdrawn
TolterodineThe metabolism of Tolterodine can be decreased when combined with Clobazam.Approved, Investigational
TolvaptanThe serum concentration of Clobazam can be increased when it is combined with Tolvaptan.Approved
TopiramateThe risk or severity of adverse effects can be increased when Topiramate is combined with Clobazam.Approved
TrabectedinThe metabolism of Trabectedin can be decreased when combined with Clobazam.Approved, Investigational
TramadolThe therapeutic efficacy of Tramadol can be decreased when used in combination with Clobazam.Approved, Investigational
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Trans-2-Phenylcyclopropylamine is combined with Clobazam.Experimental
TranylcypromineThe risk or severity of adverse effects can be increased when Tranylcypromine is combined with Clobazam.Approved
TrazodoneThe serum concentration of Clobazam can be decreased when it is combined with Trazodone.Approved, Investigational
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with Clobazam.Approved
TrifluoperazineThe serum concentration of Clobazam can be increased when it is combined with Trifluoperazine.Approved
TriflupromazineThe serum concentration of Clobazam can be increased when it is combined with Triflupromazine.Approved, Vet Approved
TrimethoprimThe serum concentration of Clobazam can be decreased when it is combined with Trimethoprim.Approved, Vet Approved
TrimipramineThe serum concentration of Clobazam can be increased when it is combined with Trimipramine.Approved
TriprolidineThe risk or severity of adverse effects can be increased when Clobazam is combined with Triprolidine.Approved
TroleandomycinThe serum concentration of Clobazam can be increased when it is combined with Troleandomycin.Approved
Uc1010The risk or severity of adverse effects can be increased when Clobazam is combined with Uc1010.Investigational
UmeclidiniumThe metabolism of Umeclidinium can be decreased when combined with Clobazam.Approved
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Clobazam.Approved, Investigational
VenlafaxineThe metabolism of Clobazam can be decreased when combined with Venlafaxine.Approved
VerapamilThe metabolism of Clobazam can be decreased when combined with Verapamil.Approved
VigabatrinThe risk or severity of adverse effects can be increased when Clobazam is combined with Vigabatrin.Approved
VilazodoneThe metabolism of Vilazodone can be decreased when combined with Clobazam.Approved
VinblastineThe serum concentration of Clobazam can be decreased when it is combined with Vinblastine.Approved
VincristineThe serum concentration of Clobazam can be decreased when it is combined with Vincristine.Approved, Investigational
VinorelbineThe serum concentration of Clobazam can be increased when it is combined with Vinorelbine.Approved, Investigational
VoriconazoleThe metabolism of Clobazam can be decreased when combined with Voriconazole.Approved, Investigational
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Clobazam.Approved
XylazineThe risk or severity of adverse effects can be increased when Xylazine is combined with Clobazam.Vet Approved
YohimbineThe therapeutic efficacy of Clobazam can be decreased when used in combination with Yohimbine.Approved, Vet Approved
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Clobazam.Approved
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with Clobazam.Approved, Illicit, Investigational
ZiconotideThe risk or severity of adverse effects can be increased when Clobazam is combined with Ziconotide.Approved
ZimelidineThe serum concentration of Clobazam can be increased when it is combined with Zimelidine.Withdrawn
ZiprasidoneThe metabolism of Clobazam can be decreased when combined with Ziprasidone.Approved
ZolazepamThe risk or severity of adverse effects can be increased when Zolazepam is combined with Clobazam.Vet Approved
ZolpidemClobazam may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.Approved
ZonisamideThe risk or severity of adverse effects can be increased when Clobazam is combined with Zonisamide.Approved, Investigational
ZopicloneThe risk or severity of adverse effects can be increased when Zopiclone is combined with Clobazam.Approved
ZotepineThe risk or severity of adverse effects can be increased when Zotepine is combined with Clobazam.Approved
ZuclopenthixolThe metabolism of Zuclopenthixol can be decreased when combined with Clobazam.Approved, Investigational
Food Interactions
  • Alcohol increases clobazam absorption by 50%.
  • Take without regard to meals.
References
Synthesis Reference

Hauptmann, K.H., Weber, K.-H., Zeile, K., Danneberg, P. and Giesemann, R.; South African
Patent 68/0803; February 7,1968; assigned to Boehringer lngelheim GmbH, Germany.

General References
  1. Freche C: [Study of an anxiolytic, clobazam, in otorhinolaryngology in psychosomatic pharyngeal manifestations]. Sem Hop Ther. 1975 Apr;51(4):261-3. [PubMed:5777 ]
  2. Authors unspecified: Clobazam in treatment of refractory epilepsy: the Canadian experience. A retrospective study. Canadian Clobazam Cooperative Group. Epilepsia. 1991 May-Jun;32(3):407-16. [PubMed:2044502 ]
  3. Wildin JD, Pleuvry BJ, Mawer GE, Onon T, Millington L: Respiratory and sedative effects of clobazam and clonazepam in volunteers. Br J Clin Pharmacol. 1990 Feb;29(2):169-77. [PubMed:2106335 ]
  4. Kilpatrick C, Bury R, Fullinfaw R, Moulds R: Clobazam in the treatment of epilepsy. Clin Exp Neurol. 1987;23:139-44. [PubMed:3117456 ]
  5. Giarratano M, Standley K, Benbadis SR: Clobazam for treatment of epilepsy. Expert Opin Pharmacother. 2012 Feb;13(2):227-33. doi: 10.1517/14656566.2012.647686. Epub 2012 Jan 13. [PubMed:22242724 ]
  6. Yang LP, Scott LJ: Clobazam : in patients with Lennox-Gastaut syndrome. CNS Drugs. 2012 Nov;26(11):983-91. doi: 10.1007/s40263-012-0007-0. [PubMed:23034582 ]
  7. Walzer M, Bekersky I, Blum RA, Tolbert D: Pharmacokinetic drug interactions between clobazam and drugs metabolized by cytochrome P450 isoenzymes. Pharmacotherapy. 2012 Apr;32(4):340-53. doi: 10.1002/j.1875-9114.2012.01028.x. Epub 2012 Mar 15. [PubMed:22422635 ]
External Links
ATC CodesN05BA09
AHFS Codes
  • 28:24.08
PDB EntriesNot Available
FDA labelDownload (595 KB)
MSDSDownload (57.5 KB)
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.99
Blood Brain Barrier+0.9904
Caco-2 permeable+0.7487
P-glycoprotein substrateNon-substrate0.5733
P-glycoprotein inhibitor INon-inhibitor0.5462
P-glycoprotein inhibitor IINon-inhibitor0.9204
Renal organic cation transporterNon-inhibitor0.7373
CYP450 2C9 substrateNon-substrate0.7058
CYP450 2D6 substrateNon-substrate0.8607
CYP450 3A4 substrateSubstrate0.6871
CYP450 1A2 substrateNon-inhibitor0.6829
CYP450 2C9 inhibitorNon-inhibitor0.5296
CYP450 2D6 inhibitorNon-inhibitor0.8908
CYP450 2C19 inhibitorNon-inhibitor0.5791
CYP450 3A4 inhibitorInhibitor0.7008
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.5308
Ames testNon AMES toxic0.9132
CarcinogenicityNon-carcinogens0.7846
BiodegradationNot ready biodegradable1.0
Rat acute toxicity1.7313 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9896
hERG inhibition (predictor II)Non-inhibitor0.8651
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage forms
FormRouteStrength
TabletOral10 mg
SuspensionOral2.5 mg/mL
TabletOral10 mg/1
TabletOral20 mg/1
TabletOral5 mg/1
Prices
Unit descriptionCostUnit
Apo-Clobazam 10 mg Tablet0.23USD tablet
Novo-Clobazam 10 mg Tablet0.23USD tablet
Pms-Clobazam 10 mg Tablet0.23USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point180-182Hauptmann, K.H., Weber, K.-H., Zeile, K., Danneberg, P. and Giesemann, R.; South African Patent 68/0803; February 7,1968; assigned to Boehringer lngelheim GmbH, Germany.
water solubility188 mg/LNot Available
logP2.12HENCZI,M ET AL. (1995)
Predicted Properties
PropertyValueSource
Water Solubility0.164 mg/mLALOGPS
logP2.14ALOGPS
logP2.55ChemAxon
logS-3.3ALOGPS
pKa (Strongest Acidic)4.07ChemAxon
pKa (Strongest Basic)-6.7ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area40.62 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity80.3 m3·mol-1ChemAxon
Polarizability30.07 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Download (11.4 KB)
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
MSMass Spectrum (Electron Ionization)splash10-0pb9-6392000000-a76f30f353b3407df0c6View in MoNA
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as benzodiazepines. These are organic compounds containing a benzene ring fused to either isomers of diazepine(unsaturated seven-member heterocycle with two nitrogen atoms replacing two carbon atoms).
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassBenzodiazepines
Sub ClassNot Available
Direct ParentBenzodiazepines
Alternative Parents
Substituents
  • Benzodiazepine
  • Chlorobenzene
  • Para-diazepine
  • Benzenoid
  • 1,3-dicarbonyl compound
  • Monocyclic benzene moiety
  • Aryl halide
  • Aryl chloride
  • Tertiary carboxylic acid amide
  • Tertiary amine
  • Lactam
  • Carboxamide group
  • Azacycle
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Organochloride
  • Organohalogen compound
  • Carbonyl group
  • Amine
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors

Targets

Kind
Protein group
Organism
Human
Pharmacological action
yes
Actions
positive allosteric modulator
General Function:
Inhibitory extracellular ligand-gated ion channel activity
Specific Function:
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel (By similarity).
Components:
NameUniProt IDDetails
Gamma-aminobutyric acid receptor subunit alpha-1P14867 Details
Gamma-aminobutyric acid receptor subunit alpha-2P47869 Details
Gamma-aminobutyric acid receptor subunit alpha-3P34903 Details
Gamma-aminobutyric acid receptor subunit alpha-4P48169 Details
Gamma-aminobutyric acid receptor subunit alpha-5P31644 Details
Gamma-aminobutyric acid receptor subunit alpha-6Q16445 Details
Gamma-aminobutyric acid receptor subunit beta-1P18505 Details
Gamma-aminobutyric acid receptor subunit beta-2P47870 Details
Gamma-aminobutyric acid receptor subunit beta-3P28472 Details
Gamma-aminobutyric acid receptor subunit deltaO14764 Details
Gamma-aminobutyric acid receptor subunit epsilonP78334 Details
Gamma-aminobutyric acid receptor subunit gamma-1Q8N1C3 Details
Gamma-aminobutyric acid receptor subunit gamma-2P18507 Details
Gamma-aminobutyric acid receptor subunit gamma-3Q99928 Details
Gamma-aminobutyric acid receptor subunit piO00591 Details
Gamma-aminobutyric acid receptor subunit thetaQ9UN88 Details
References
  1. Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. [PubMed:11752090 ]
  2. Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. doi: 10.1111/j.1600-0404.2008.01004.x. Epub 2008 Mar 31. [PubMed:18384456 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Gene Name:
CYP2B6
Uniprot ID:
P20813
Molecular Weight:
56277.81 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP2C18
Uniprot ID:
P33260
Molecular Weight:
55710.075 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da

Transporters

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
Other
General Function:
Neurotransmitter:sodium symporter activity
Specific Function:
Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.
Gene Name:
SLC6A1
Uniprot ID:
P30531
Molecular Weight:
67073.0 Da
References
  1. Giarratano M, Standley K, Benbadis SR: Clobazam for treatment of epilepsy. Expert Opin Pharmacother. 2012 Feb;13(2):227-33. doi: 10.1517/14656566.2012.647686. Epub 2012 Jan 13. [PubMed:22242724 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
Other
General Function:
Neurotransmitter:sodium symporter activity
Specific Function:
Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.
Gene Name:
SLC6A11
Uniprot ID:
P48066
Molecular Weight:
70605.145 Da
References
  1. Giarratano M, Standley K, Benbadis SR: Clobazam for treatment of epilepsy. Expert Opin Pharmacother. 2012 Feb;13(2):227-33. doi: 10.1517/14656566.2012.647686. Epub 2012 Jan 13. [PubMed:22242724 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
Comments
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23