Identification

Name
Clobazam
Accession Number
DB00349  (APRD00307)
Type
Small Molecule
Groups
Approved, Illicit
Description

Clobazam belongs to the 1,5-benzodiazepine class of drugs and is expected to have a better side-effect profile compared to older 1,4-benzodiazepines. It has been marketed as an anxiolytic since 1975 and an anticonvulsant since 1984. The oral preparation was FDA approved on October 21, 2011. An oral suspension is expected to be available in 2013.

Structure
Thumb
Synonyms
  • 1-phenyl-5-methyl-8-chloro-1,2,4,5-tetrahydro-2,4-dioxo-3H-1,5-benzodiazepine
  • 7-Chloro-1-methyl-5-phenyl-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione
  • Clobazam
  • Clobazamum
External IDs
H 4723 / H-4723 / HR 376 / HR-376 / LM 2717 / LM-2717
Product Images
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Clobazam-10Tablet10 mgOralPro Doc Limitee2003-12-09Not applicableCanada
Frisium Tab 10mgTablet10 mgOralHoechst Canada Inc.1991-12-311996-08-29Canada
Frisium Tablet 10mgTablet10 mgOralLundbeck Inc.1997-03-24Not applicableCanada
Frisium Tablets 10mgTablet10 mgOralHoechst Roussel Canada Inc.1994-12-311999-08-11Canada
OnfiTablet5 mg/1OralLundbeck Inc.2011-10-212016-02-28Us
OnfiTablet20 mg/1OralLundbeck Pharmaceuticals Llc2013-12-10Not applicableUs67386 0315 01 nlmimage10 123f892c
OnfiTablet20 mg/1OralLundbeck Inc.2013-08-122016-06-30Us
OnfiTablet10 mg/1OralLundbeck Pharmaceuticals Llc2013-12-10Not applicableUs67386 0314 01 nlmimage10 173f8b9c
OnfiTablet10 mg/1OralLundbeck Inc.2013-08-122016-04-30Us
OnfiSuspension2.5 mg/mLOralLundbeck Pharmaceuticals Llc2012-12-14Not applicableUs
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-clobazamTablet10 mgOralApotex Corporation2001-11-28Not applicableCanada
Dom-clobazamTablet10 mgOralDominion Pharmacal2003-03-272016-10-25Canada
Ntp-clobazamTablet10 mgOralTevaNot applicableNot applicableCanada
PMS-clobazamTablet10 mgOralPharmascience Inc2001-11-16Not applicableCanada
Ratio-clobazamTablet10 mgOralRatiopharm Inc Division Of Teva Canada Limited1998-11-302010-08-02Canada
Teva-clobazamTablet10 mgOralTeva1998-07-07Not applicableCanada
International/Other Brands
Aedon (Sanofi-Aventis) / Castilium (Sanofi-Aventis) / Clobam (Square) / Clobamax (Sherfarma) / Frisium (Sanofi-Aventis) / Grifoclobam (Chile) / Mystan (Dainippon Sumitomo) / Noiafren (Sanofi Aventis) / Sederlona / Urbanil (Sanofi-Aventis) / Urbanol (Sanofi-Aventis) / Urbanyl (Sanofi-Aventis) / Venium (Hudson)
Categories
UNII
2MRO291B4U
CAS number
22316-47-8
Weight
Average: 300.74
Monoisotopic: 300.066555377
Chemical Formula
C16H13ClN2O2
InChI Key
CXOXHMZGEKVPMT-UHFFFAOYSA-N
InChI
InChI=1S/C16H13ClN2O2/c1-18-13-8-7-11(17)9-14(13)19(16(21)10-15(18)20)12-5-3-2-4-6-12/h2-9H,10H2,1H3
IUPAC Name
7-chloro-1-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-2,4-dione
SMILES
CN1C2=C(C=C(Cl)C=C2)N(C2=CC=CC=C2)C(=O)CC1=O

Pharmacology

Indication

For treatment and management of epilepsy and seizures associated with Lennox-Gastaut syndrome, a difficult-to-treat form of childhood epilepsy.

Associated Conditions
Pharmacodynamics

Similar to other benzodiazepines, clobazam binds to the interface of the α and γ2-subunit of the GABA-A receptor. However, it is considered a partial agonist to GABA-A receptors which sets clobazam apart from 1,4-benzodiazepines which are full agonist. The significance of this difference is that one may experience less sedation with clobazam than with other benzodiazepines. Unlike the endogenous GABA ligand, clobazam binds allosterically to the GABA receptor to increase the frequency of the chloride channel opening and membrane permeability to chloride ions. Pharmacodynamic tolerance has been demonstrated in animal models.

Mechanism of action

Clobazam binds at distinct binding sites associated with the chloride ionopore at the post-synaptic GABA receptor. These GABA receptors are in various locations in the CNS (limbic, reticular formation) and clobazam increases the duration of time for which the chloride ionopore is open. As a result, hyper polarization and stabilization of the membrane occur as the post-synaptic inhibitory effect of GABA is enhanced.

TargetActionsOrganism
AGABA-A receptor (anion channel)
positive allosteric modulator
Human
Absorption

After oral administration of clobazam, it is almost completely absorbed (87% of dose). Bioavailability relative to solution was almost at 100%. Food does not affect absorption. Tmax = 1-3 hours.

Volume of distribution

Vdss = 100 L. This high volume of distribution suggests extensive distribution to body tissues.

Protein binding

Clobazam is the primary circulating entity in the serum and is highly protein-bound (80-90%).

Metabolism

Clobazam is extensively metabolized in the liver via N-demethylation and hydroxylation. Clobazam has two major metabolites: N-desmethylclobazam (norclobazam) and 4'-hydroxyclobazam, the former of which is active. Norclobazam is one-fourth the potency of clobazam. The main enzyme that facilitates the process of N-demethylation is CYP3A4, and to a lesser extent by CYP2C19 and CYP2B6. Norclobazam itself is also metabolized via hydroxylation, primarily by CYP2C19. The formation of 4'-hydroxyclobazam is facilitated by CYP2C18 and CYP2C19. A factor in determining extent of metabolism is the genetic profile of the individual patient as CYP2C19 is a polymorphic enzyme.

Route of elimination

Clobazam is eliminated via the urine (~94%) as metabolites.

Half life

The mean elimination half life of an oral dose of clobazam 40 mg is 32 hours. It's main metabolite, norclobazam, as a half life of 57 hours. The half life in adult patients with epilepsy are higher than those that are healthy.

Clearance

Median estimated clearance = 2.49 L/h

Toxicity

The most common adverse effects include somnolence, pyrexia, upper respiratory tract infection, and lethargy.

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Interacting Gene/EnzymeAllele nameGenotype(s)Defining Change(s)Type(s)DescriptionDetails
Cytochrome P450 2C19CYP2C19*2(A;A) / (A;G)G > A/CADR Directly StudiedPatients with this genotype have reduced metabolism of clobazam.Details
Cytochrome P450 2C19CYP2C19*2ANot Available681G>AADR InferredClobazem is metabolized into N-desmethylclobazem (NCLB) mostly by CYP3A4. NCLB is primarily metabolized by 2C19. Those with one 2C19*2 allele mutation (1*/2*) are intermediate metabolizers of NCLB. Those with two (2*/2*) mutations will metabolize NCLB poorly in comparisone to extensive metabolizers (1*/1*). Levels of NCLB can be five times higher in poor metabolizers, and two times higher in intermediate metabolizers as compared to individuals who are extensive metabolizers. The safety and efficacy of clobazem may be affected by polymorphic expression of CYP2C19*2.Details
Cytochrome P450 2C19CYP2C19*2BNot Available681G>AADR InferredClobazem is metabolized into N-desmethylclobazem (NCLB) mostly by CYP3A4. NCLB is primarily metabolized by 2C19. Those with one 2C19*2 allele mutation (1*/2*) are intermediate metabolizers of NCLB. Those with two (2*/2*) mutations will metabolize NCLB poorly in comparisone to extensive metabolizers (1*/1*). Levels of NCLB can be five times higher in poor metabolizers, and two times higher in intermediate metabolizers as compared to individuals who are extensive metabolizers. The safety and efficacy of clobazem may be affected by polymorphic expression of CYP2C19*2.Details
Cytochrome P450 2C19CYP2C19*3Not Available636G>AADR InferredClobazem is metabolized into N-desmethylclobazem (NCLB) mostly by CYP3A4. NCLB is primarily metabolized by 2C19. Those with one 2C19*2 allele mutation (1*/2*) are intermediate metabolizers of NCLB. Those with two (2*/2*) mutations will metabolize NCLB poorly in comparisone to extensive metabolizers (1*/1*). Levels of NCLB can be five times higher in poor metabolizers, and two times higher in intermediate metabolizers as compared to individuals who are extensive metabolizers. The safety and efficacy of clobazem may be affected by polymorphic expression of CYP2C19*2.Details
Cytochrome P450 2C19CYP2C19*4Not Available1A>GADR InferredClobazem is metabolized into N-desmethylclobazem (NCLB) mostly by CYP3A4. NCLB is primarily metabolized by 2C19. Those with one 2C19*2 allele mutation (1*/2*) are intermediate metabolizers of NCLB. Those with two (2*/2*) mutations will metabolize NCLB poorly in comparisone to extensive metabolizers (1*/1*). Levels of NCLB can be five times higher in poor metabolizers, and two times higher in intermediate metabolizers as compared to individuals who are extensive metabolizers. The safety and efficacy of clobazem may be affected by polymorphic expression of CYP2C19*2.Details
Cytochrome P450 2C19CYP2C19*5Not Available1297C>TADR InferredClobazem is metabolized into N-desmethylclobazem (NCLB) mostly by CYP3A4. NCLB is primarily metabolized by 2C19. Those with one 2C19*2 allele mutation (1*/2*) are intermediate metabolizers of NCLB. Those with two (2*/2*) mutations will metabolize NCLB poorly in comparisone to extensive metabolizers (1*/1*). Levels of NCLB can be five times higher in poor metabolizers, and two times higher in intermediate metabolizers as compared to individuals who are extensive metabolizers. The safety and efficacy of clobazem may be affected by polymorphic expression of CYP2C19*2.Details
Cytochrome P450 2C19CYP2C19*6Not Available395G>AADR InferredClobazem is metabolized into N-desmethylclobazem (NCLB) mostly by CYP3A4. NCLB is primarily metabolized by 2C19. Those with one 2C19*2 allele mutation (1*/2*) are intermediate metabolizers of NCLB. Those with two (2*/2*) mutations will metabolize NCLB poorly in comparisone to extensive metabolizers (1*/1*). Levels of NCLB can be five times higher in poor metabolizers, and two times higher in intermediate metabolizers as compared to individuals who are extensive metabolizers. The safety and efficacy of clobazem may be affected by polymorphic expression of CYP2C19*2.Details
Cytochrome P450 2C19CYP2C19*7Not Available19294T>AADR InferredClobazem is metabolized into N-desmethylclobazem (NCLB) mostly by CYP3A4. NCLB is primarily metabolized by 2C19. Those with one 2C19*2 allele mutation (1*/2*) are intermediate metabolizers of NCLB. Those with two (2*/2*) mutations will metabolize NCLB poorly in comparisone to extensive metabolizers (1*/1*). Levels of NCLB can be five times higher in poor metabolizers, and two times higher in intermediate metabolizers as compared to individuals who are extensive metabolizers. The safety and efficacy of clobazem may be affected by polymorphic expression of CYP2C19*2.Details
Cytochrome P450 2C19CYP2C19*22Not Available557G>C / 991A>GADR InferredClobazem is metabolized into N-desmethylclobazem (NCLB) mostly by CYP3A4. NCLB is primarily metabolized by 2C19. Those with one 2C19*2 allele mutation (1*/2*) are intermediate metabolizers of NCLB. Those with two (2*/2*) mutations will metabolize NCLB poorly in comparisone to extensive metabolizers (1*/1*). Levels of NCLB can be five times higher in poor metabolizers, and two times higher in intermediate metabolizers as compared to individuals who are extensive metabolizers. The safety and efficacy of clobazem may be affected by polymorphic expression of CYP2C19*2.Details
Cytochrome P450 2C19CYP2C19*24Not Available99C>T / 991A>G  … show all ADR InferredClobazem is metabolized into N-desmethylclobazem (NCLB) mostly by CYP3A4. NCLB is primarily metabolized by 2C19. Those with one 2C19*2 allele mutation (1*/2*) are intermediate metabolizers of NCLB. Those with two (2*/2*) mutations will metabolize NCLB poorly in comparisone to extensive metabolizers (1*/1*). Levels of NCLB can be five times higher in poor metabolizers, and two times higher in intermediate metabolizers as compared to individuals who are extensive metabolizers. The safety and efficacy of clobazem may be affected by polymorphic expression of CYP2C19*2.Details
Cytochrome P450 2C19CYP2C19*35Not Available12662A>GADR InferredClobazem is metabolized into N-desmethylclobazem (NCLB) mostly by CYP3A4. NCLB is primarily metabolized by 2C19. Those with one 2C19*2 allele mutation (1*/2*) are intermediate metabolizers of NCLB. Those with two (2*/2*) mutations will metabolize NCLB poorly in comparisone to extensive metabolizers (1*/1*). Levels of NCLB can be five times higher in poor metabolizers, and two times higher in intermediate metabolizers as compared to individuals who are extensive metabolizers. The safety and efficacy of clobazem may be affected by polymorphic expression of CYP2C19*2.Details

Interactions

Drug Interactions
DrugInteractionDrug group
4-MethoxyamphetamineThe metabolism of 4-Methoxyamphetamine can be decreased when combined with Clobazam.Experimental, Illicit
7-NitroindazoleThe risk or severity of adverse effects can be increased when Clobazam is combined with 7-Nitroindazole.Experimental
AbirateroneThe metabolism of Clobazam can be decreased when combined with Abiraterone.Approved
AcepromazineThe risk or severity of adverse effects can be increased when Clobazam is combined with Acepromazine.Approved, Vet Approved
AceprometazineThe risk or severity of adverse effects can be increased when Clobazam is combined with Aceprometazine.Approved
AcetaminophenThe serum concentration of Clobazam can be increased when it is combined with Acetaminophen.Approved
Acetyl sulfisoxazoleThe metabolism of Clobazam can be decreased when combined with Acetyl sulfisoxazole.Approved, Vet Approved
AcetylcholineThe metabolism of Acetylcholine can be decreased when combined with Clobazam.Approved
AdipiplonThe risk or severity of adverse effects can be increased when Clobazam is combined with Adipiplon.Investigational
AgomelatineThe risk or severity of adverse effects can be increased when Clobazam is combined with Agomelatine.Approved, Investigational
AjmalineThe metabolism of Ajmaline can be decreased when combined with Clobazam.Approved, Investigational
AlaproclateThe risk or severity of adverse effects can be increased when Clobazam is combined with Alaproclate.Experimental
AlfaxaloneThe risk or severity of adverse effects can be increased when Clobazam is combined with Alfaxalone.Vet Approved
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Clobazam.Approved, Illicit
AllopregnanoloneThe risk or severity of adverse effects can be increased when Clobazam is combined with Allopregnanolone.Investigational
AlmotriptanThe metabolism of Almotriptan can be decreased when combined with Clobazam.Approved, Investigational
AlogliptinThe metabolism of Alogliptin can be decreased when combined with Clobazam.Approved
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Clobazam is combined with Alphacetylmethadol.Experimental, Illicit
AlphaprodineThe risk or severity of adverse effects can be increased when Clobazam is combined with Alphaprodine.Illicit
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Clobazam.Approved, Illicit, Investigational
AlprenololThe metabolism of Alprenolol can be decreased when combined with Clobazam.Approved, Withdrawn
Ambroxol acefyllinateThe therapeutic efficacy of Clobazam can be decreased when used in combination with Ambroxol acefyllinate.Experimental, Investigational
AmikacinThe risk or severity of adverse effects can be increased when Clobazam is combined with Amikacin.Approved, Investigational, Vet Approved
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Clobazam.Approved, Withdrawn
AminophyllineThe therapeutic efficacy of Clobazam can be decreased when used in combination with Aminophylline.Approved
AmiodaroneThe serum concentration of Clobazam can be increased when it is combined with Amiodarone.Approved, Investigational
AmisulprideThe risk or severity of adverse effects can be increased when Clobazam is combined with Amisulpride.Approved, Investigational
AmitriptylineThe metabolism of Amitriptyline can be decreased when combined with Clobazam.Approved
AmlodipineThe serum concentration of Clobazam can be increased when it is combined with Amlodipine.Approved
AmobarbitalThe risk or severity of adverse effects can be increased when Amobarbital is combined with Clobazam.Approved, Illicit
AmoxapineThe metabolism of Amoxapine can be decreased when combined with Clobazam.Approved
AmperozideThe risk or severity of adverse effects can be increased when Clobazam is combined with Amperozide.Experimental
AmphetamineThe metabolism of Amphetamine can be decreased when combined with Clobazam.Approved, Illicit, Investigational
AmprenavirThe metabolism of Amprenavir can be decreased when combined with Clobazam.Approved, Investigational
AmsacrineThe metabolism of Amsacrine can be decreased when combined with Clobazam.Approved, Investigational
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Clobazam.Approved, Investigational
ApalutamideThe serum concentration of Clobazam can be decreased when it is combined with Apalutamide.Approved, Investigational
AprepitantThe serum concentration of Clobazam can be increased when it is combined with Aprepitant.Approved, Investigational
AprindineThe metabolism of Aprindine can be decreased when combined with Clobazam.Approved
ArformoterolThe metabolism of Arformoterol can be decreased when combined with Clobazam.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be decreased when it is combined with Clobazam.Approved, Investigational
ArmodafinilThe metabolism of Clobazam can be decreased when combined with Armodafinil.Approved, Investigational
ArtemetherThe metabolism of Artemether can be decreased when combined with Clobazam.Approved
ArticaineThe risk or severity of adverse effects can be increased when Clobazam is combined with Articaine.Approved
AsenapineThe risk or severity of adverse effects can be increased when Asenapine is combined with Clobazam.Approved
AstemizoleThe metabolism of Astemizole can be decreased when combined with Clobazam.Approved, Withdrawn
AsunaprevirThe serum concentration of Asunaprevir can be decreased when it is combined with Clobazam.Approved, Investigational, Withdrawn
AtazanavirThe metabolism of Clobazam can be decreased when combined with Atazanavir.Approved, Investigational
AtomoxetineThe metabolism of Clobazam can be decreased when combined with Atomoxetine.Approved
AzaperoneThe risk or severity of adverse effects can be increased when Clobazam is combined with Azaperone.Investigational, Vet Approved
AzelastineClobazam may increase the central nervous system depressant (CNS depressant) activities of Azelastine.Approved
BaclofenThe risk or severity of adverse effects can be increased when Baclofen is combined with Clobazam.Approved
BarbitalThe risk or severity of adverse effects can be increased when Clobazam is combined with Barbital.Illicit
BenperidolThe risk or severity of adverse effects can be increased when Clobazam is combined with Benperidol.Approved, Investigational
BenzphetamineThe risk or severity of adverse effects can be increased when Clobazam is combined with Benzphetamine.Approved, Illicit
Benzyl alcoholThe risk or severity of adverse effects can be increased when Clobazam is combined with Benzyl alcohol.Approved
BepridilThe serum concentration of Clobazam can be increased when it is combined with Bepridil.Approved, Withdrawn
BetaxololThe metabolism of Betaxolol can be decreased when combined with Clobazam.Approved, Investigational
BisoprololThe metabolism of Bisoprolol can be decreased when combined with Clobazam.Approved
BoceprevirThe metabolism of Clobazam can be decreased when combined with Boceprevir.Approved, Withdrawn
BortezomibThe metabolism of Clobazam can be decreased when combined with Bortezomib.Approved, Investigational
BosentanThe serum concentration of Clobazam can be decreased when it is combined with Bosentan.Approved, Investigational
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Clobazam.Approved, Investigational
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Clobazam.Approved
BromazepamThe risk or severity of adverse effects can be increased when Bromazepam is combined with Clobazam.Approved, Illicit, Investigational
BromisovalThe risk or severity of adverse effects can be increased when Clobazam is combined with Bromisoval.Experimental
BromperidolThe risk or severity of adverse effects can be increased when Clobazam is combined with Bromperidol.Approved, Investigational
BrompheniramineThe risk or severity of adverse effects can be increased when Clobazam is combined with Brompheniramine.Approved
BrotizolamThe risk or severity of adverse effects can be increased when Clobazam is combined with Brotizolam.Approved, Investigational, Withdrawn
BufuralolThe metabolism of Bufuralol can be decreased when combined with Clobazam.Experimental, Investigational
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Clobazam.Approved, Investigational
BuprenorphineClobazam may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BupropionThe risk or severity of adverse effects can be increased when Clobazam is combined with Bupropion.Approved
BuspironeThe metabolism of Buspirone can be decreased when combined with Clobazam.Approved, Investigational
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Clobazam.Approved, Illicit
ButacaineThe risk or severity of adverse effects can be increased when Clobazam is combined with Butacaine.Vet Approved
ButalbitalThe risk or severity of adverse effects can be increased when Butalbital is combined with Clobazam.Approved, Illicit
ButambenThe risk or severity of adverse effects can be increased when Clobazam is combined with Butamben.Approved, Withdrawn
ButethalThe risk or severity of adverse effects can be increased when Clobazam is combined with Butethal.Approved, Illicit
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Clobazam.Approved, Illicit, Vet Approved
CaffeineThe therapeutic efficacy of Clobazam can be decreased when used in combination with Caffeine.Approved
CanertinibThe risk or severity of adverse effects can be increased when Clobazam is combined with Canertinib.Investigational
CaptoprilThe metabolism of Captopril can be decreased when combined with Clobazam.Approved
CarbamazepineThe metabolism of Clobazam can be increased when combined with Carbamazepine.Approved, Investigational
CarbinoxamineThe risk or severity of adverse effects can be increased when Clobazam is combined with Carbinoxamine.Approved
CarfentanilThe risk or severity of adverse effects can be increased when Clobazam is combined with Carfentanil.Illicit, Investigational, Vet Approved
CariprazineThe metabolism of Cariprazine can be decreased when combined with Clobazam.Approved, Investigational
CarisoprodolThe risk or severity of adverse effects can be increased when Clobazam is combined with Carisoprodol.Approved
CarteololThe metabolism of Carteolol can be decreased when combined with Clobazam.Approved
CarvedilolThe serum concentration of Clobazam can be increased when it is combined with Carvedilol.Approved, Investigational
CephalexinThe metabolism of Cephalexin can be decreased when combined with Clobazam.Approved, Investigational, Vet Approved
CeritinibThe serum concentration of Clobazam can be increased when it is combined with Ceritinib.Approved
CetirizineThe risk or severity of adverse effects can be increased when Cetirizine is combined with Clobazam.Approved
CevimelineThe metabolism of Cevimeline can be decreased when combined with Clobazam.Approved
Chloral hydrateThe risk or severity of adverse effects can be increased when Clobazam is combined with Chloral hydrate.Approved, Illicit, Investigational, Vet Approved
ChloramphenicolThe metabolism of Clobazam can be decreased when combined with Chloramphenicol.Approved, Vet Approved
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Clobazam.Approved, Illicit, Investigational
ChlormadinoneThe serum concentration of Chlormadinone can be decreased when it is combined with Clobazam.Experimental
ChlormezanoneThe risk or severity of adverse effects can be increased when Clobazam is combined with Chlormezanone.Approved, Investigational, Withdrawn
ChloroprocaineThe risk or severity of adverse effects can be increased when Clobazam is combined with Chloroprocaine.Approved
ChloroquineThe metabolism of Chloroquine can be decreased when combined with Clobazam.Approved, Investigational, Vet Approved
ChlorphenamineThe risk or severity of adverse effects can be increased when Clobazam is combined with Chlorphenamine.Approved
ChlorpromazineThe metabolism of Chlorpromazine can be decreased when combined with Clobazam.Approved, Investigational, Vet Approved
ChlorprothixeneThe risk or severity of adverse effects can be increased when Clobazam is combined with Chlorprothixene.Approved, Investigational, Withdrawn
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Clobazam.Approved
CholecalciferolThe metabolism of Clobazam can be decreased when combined with Cholecalciferol.Approved, Nutraceutical
CilostazolThe metabolism of Cilostazol can be decreased when combined with Clobazam.Approved, Investigational
CinchocaineThe risk or severity of adverse effects can be increased when Clobazam is combined with Cinchocaine.Approved, Vet Approved
CitalopramThe metabolism of Citalopram can be decreased when combined with Clobazam.Approved
ClarithromycinThe metabolism of Clobazam can be decreased when combined with Clarithromycin.Approved
ClemastineThe risk or severity of adverse effects can be increased when Clemastine is combined with Clobazam.Approved, Investigational
ClidiniumThe risk or severity of adverse effects can be increased when Clobazam is combined with Clidinium.Approved
ClindamycinThe risk or severity of adverse effects can be increased when Clobazam is combined with Clindamycin.Approved, Vet Approved
clomethiazoleThe risk or severity of adverse effects can be increased when Clobazam is combined with clomethiazole.Investigational
ClomipramineThe metabolism of Clomipramine can be decreased when combined with Clobazam.Approved, Investigational, Vet Approved
ClonazepamThe risk or severity of adverse effects can be increased when Clobazam is combined with Clonazepam.Approved, Illicit
ClonidineThe metabolism of Clonidine can be decreased when combined with Clobazam.Approved
ClopenthixolThe risk or severity of adverse effects can be increased when Clobazam is combined with Clopenthixol.Experimental
ClopidogrelThe metabolism of Clobazam can be decreased when combined with Clopidogrel.Approved
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Clobazam.Approved, Illicit
ClothiapineThe risk or severity of adverse effects can be increased when Clobazam is combined with Clothiapine.Experimental
ClotrimazoleThe metabolism of Clobazam can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineThe risk or severity of adverse effects can be increased when Clobazam is combined with Clozapine.Approved
CobicistatThe metabolism of Clobazam can be decreased when combined with Cobicistat.Approved
CocaineThe risk or severity of adverse effects can be increased when Clobazam is combined with Cocaine.Approved, Illicit
CodeineThe therapeutic efficacy of Codeine can be decreased when used in combination with Clobazam.Approved, Illicit
ConivaptanThe serum concentration of Conivaptan can be increased when it is combined with Clobazam.Approved, Investigational
CrizotinibThe metabolism of Clobazam can be decreased when combined with Crizotinib.Approved
CurcuminThe metabolism of Clobazam can be decreased when combined with Curcumin.Approved, Investigational
CyclizineThe risk or severity of adverse effects can be increased when Clobazam is combined with Cyclizine.Approved
CyclobenzaprineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Clobazam.Approved
CyclophosphamideThe metabolism of Cyclophosphamide can be decreased when combined with Clobazam.Approved, Investigational
CyclopropaneThe risk or severity of adverse effects can be increased when Clobazam is combined with Cyclopropane.Experimental
CyclosporineThe risk or severity of adverse effects can be increased when Clobazam is combined with Cyclosporine.Approved, Investigational, Vet Approved
CyproheptadineThe risk or severity of adverse effects can be increased when Clobazam is combined with Cyproheptadine.Approved
Cyproterone acetateThe serum concentration of Cyproterone acetate can be decreased when it is combined with Clobazam.Approved, Investigational
DabrafenibThe serum concentration of Clobazam can be decreased when it is combined with Dabrafenib.Approved, Investigational
DantroleneThe risk or severity of adverse effects can be increased when Clobazam is combined with Dantrolene.Approved, Investigational
DapiprazoleThe risk or severity of adverse effects can be increased when Clobazam is combined with Dapiprazole.Approved
DapoxetineThe risk or severity of adverse effects can be increased when Clobazam is combined with Dapoxetine.Investigational
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Clobazam.Approved, Investigational
DarunavirThe metabolism of Clobazam can be decreased when combined with Darunavir.Approved
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Clobazam.Approved
DasatinibThe serum concentration of Clobazam can be increased when it is combined with Dasatinib.Approved, Investigational
DebrisoquinThe metabolism of Debrisoquin can be decreased when combined with Clobazam.Approved, Investigational
DeferasiroxThe serum concentration of Clobazam can be decreased when it is combined with Deferasirox.Approved, Investigational
DelavirdineThe metabolism of Clobazam can be decreased when combined with Delavirdine.Approved
DeramciclaneThe risk or severity of adverse effects can be increased when Clobazam is combined with Deramciclane.Investigational
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Clobazam.Approved
DesipramineThe metabolism of Desipramine can be decreased when combined with Clobazam.Approved, Investigational
DesloratadineThe risk or severity of adverse effects can be increased when Clobazam is combined with Desloratadine.Approved, Investigational
DesogestrelThe serum concentration of Desogestrel can be decreased when it is combined with Clobazam.Approved
DesvenlafaxineThe risk or severity of adverse effects can be increased when Clobazam is combined with Desvenlafaxine.Approved, Investigational
DetomidineThe risk or severity of adverse effects can be increased when Clobazam is combined with Detomidine.Vet Approved
DeutetrabenazineThe metabolism of Deutetrabenazine can be decreased when combined with Clobazam.Approved, Investigational
DexamethasoneThe serum concentration of Clobazam can be decreased when it is combined with Dexamethasone.Approved, Investigational, Vet Approved
DexbrompheniramineThe risk or severity of adverse effects can be increased when Clobazam is combined with Dexbrompheniramine.Approved
Dexchlorpheniramine maleateThe metabolism of Dexchlorpheniramine maleate can be decreased when combined with Clobazam.Approved
DexfenfluramineThe metabolism of Dexfenfluramine can be decreased when combined with Clobazam.Approved, Illicit, Investigational, Withdrawn
DexmedetomidineThe risk or severity of adverse effects can be increased when Clobazam is combined with Dexmedetomidine.Approved, Vet Approved
DexniguldipineThe serum concentration of Clobazam can be increased when it is combined with Dexniguldipine.Experimental
DextroamphetamineThe metabolism of Dextroamphetamine can be decreased when combined with Clobazam.Approved, Illicit
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Clobazam.Approved
DextromoramideThe risk or severity of adverse effects can be increased when Clobazam is combined with Dextromoramide.Experimental, Illicit
DextropropoxypheneThe risk or severity of adverse effects can be increased when Clobazam is combined with Dextropropoxyphene.Approved, Illicit, Investigational, Withdrawn
DexverapamilThe serum concentration of Clobazam can be increased when it is combined with Dexverapamil.Experimental
DezocineThe risk or severity of adverse effects can be increased when Clobazam is combined with Dezocine.Approved, Investigational
DiazepamThe risk or severity of adverse effects can be increased when Diazepam is combined with Clobazam.Approved, Illicit, Investigational, Vet Approved
DienogestThe serum concentration of Dienogest can be decreased when it is combined with Clobazam.Approved
Diethyl etherThe risk or severity of adverse effects can be increased when Clobazam is combined with Diethyl ether.Experimental
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be decreased when it is combined with Clobazam.Approved, Investigational
DifenoxinThe risk or severity of adverse effects can be increased when Clobazam is combined with Difenoxin.Approved, Illicit
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Clobazam.Approved, Illicit
DihydroergotamineThe metabolism of Clobazam can be decreased when combined with Dihydroergotamine.Approved, Investigational
DihydroetorphineThe risk or severity of adverse effects can be increased when Clobazam is combined with Dihydroetorphine.Experimental, Illicit
DihydromorphineThe risk or severity of adverse effects can be increased when Clobazam is combined with Dihydromorphine.Experimental, Illicit
DiltiazemThe metabolism of Clobazam can be decreased when combined with Diltiazem.Approved, Investigational
DimenhydrinateThe risk or severity of adverse effects can be increased when Clobazam is combined with Dimenhydrinate.Approved
DiphenhydramineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Clobazam.Approved, Investigational
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Clobazam.Approved, Illicit
DixyrazineThe risk or severity of adverse effects can be increased when Clobazam is combined with Dixyrazine.Experimental
DolasetronThe metabolism of Dolasetron can be decreased when combined with Clobazam.Approved, Investigational
DomperidoneThe metabolism of Domperidone can be decreased when combined with Clobazam.Approved, Investigational, Vet Approved
DonepezilThe metabolism of Donepezil can be decreased when combined with Clobazam.Approved
DopamineThe metabolism of Dopamine can be decreased when combined with Clobazam.Approved
DoramectinThe risk or severity of adverse effects can be increased when Clobazam is combined with Doramectin.Vet Approved
DotarizineThe risk or severity of adverse effects can be increased when Clobazam is combined with Dotarizine.Investigational
DoxazosinThe serum concentration of Clobazam can be increased when it is combined with Doxazosin.Approved
DoxepinThe metabolism of Doxepin can be decreased when combined with Clobazam.Approved, Investigational
DoxofyllineThe serum concentration of Doxofylline can be decreased when it is combined with Clobazam.Approved, Investigational
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Clobazam.Approved, Investigational
DoxorubicinThe metabolism of Doxorubicin can be decreased when combined with Clobazam.Approved, Investigational
DoxycyclineThe metabolism of Clobazam can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Clobazam.Approved, Vet Approved
DPDPEThe risk or severity of adverse effects can be increased when Clobazam is combined with DPDPE.Experimental
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Clobazam.Approved, Illicit
DronedaroneThe metabolism of Clobazam can be decreased when combined with Dronedarone.Approved
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Clobazam.Approved, Vet Approved
DrospirenoneThe serum concentration of Drospirenone can be decreased when it is combined with Clobazam.Approved
DrotebanolThe risk or severity of adverse effects can be increased when Clobazam is combined with Drotebanol.Experimental, Illicit
DuloxetineThe metabolism of Duloxetine can be decreased when combined with Clobazam.Approved
DyclonineThe risk or severity of adverse effects can be increased when Clobazam is combined with Dyclonine.Approved
DyphyllineThe therapeutic efficacy of Clobazam can be decreased when used in combination with Dyphylline.Approved
EcgonineThe risk or severity of adverse effects can be increased when Clobazam is combined with Ecgonine.Experimental, Illicit
EcopipamThe risk or severity of adverse effects can be increased when Clobazam is combined with Ecopipam.Investigational
EfavirenzThe metabolism of Clobazam can be decreased when combined with Efavirenz.Approved, Investigational
EletriptanThe metabolism of Eletriptan can be decreased when combined with Clobazam.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Clobazam.Approved
EltanoloneThe risk or severity of adverse effects can be increased when Clobazam is combined with Eltanolone.Investigational
EmopamilThe serum concentration of Clobazam can be increased when it is combined with Emopamil.Experimental
EnasidenibThe metabolism of Enasidenib can be decreased when combined with Clobazam.Approved, Investigational
EncainideThe metabolism of Encainide can be decreased when combined with Clobazam.Approved, Investigational, Withdrawn
EnclomipheneThe metabolism of Enclomiphene can be decreased when combined with Clobazam.Investigational
EnfluraneThe risk or severity of adverse effects can be increased when Clobazam is combined with Enflurane.Approved, Investigational, Vet Approved
EntacaponeThe risk or severity of adverse effects can be increased when Clobazam is combined with Entacapone.Approved, Investigational
EnzalutamideThe serum concentration of Clobazam can be decreased when it is combined with Enzalutamide.Approved
EperisoneThe risk or severity of adverse effects can be increased when Clobazam is combined with Eperisone.Approved, Investigational
EpinastineThe metabolism of Epinastine can be decreased when combined with Clobazam.Approved, Investigational
ErlotinibThe metabolism of Erlotinib can be decreased when combined with Clobazam.Approved, Investigational
ErythromycinThe metabolism of Clobazam can be decreased when combined with Erythromycin.Approved, Investigational, Vet Approved
EscitalopramThe metabolism of Escitalopram can be decreased when combined with Clobazam.Approved, Investigational
Eslicarbazepine acetateThe metabolism of Clobazam can be decreased when combined with Eslicarbazepine acetate.Approved
EsmirtazapineThe metabolism of Esmirtazapine can be decreased when combined with Clobazam.Investigational
EstazolamThe risk or severity of adverse effects can be increased when Estazolam is combined with Clobazam.Approved, Illicit
EstradiolThe serum concentration of Estradiol can be decreased when it is combined with Clobazam.Approved, Investigational, Vet Approved
Estradiol cypionateThe serum concentration of Estradiol cypionate can be decreased when it is combined with Clobazam.Approved, Investigational, Vet Approved
Estradiol valerateThe serum concentration of Estradiol valerate can be decreased when it is combined with Clobazam.Approved, Investigational, Vet Approved
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Clobazam.Approved, Investigational
EthchlorvynolThe risk or severity of adverse effects can be increased when Clobazam is combined with Ethchlorvynol.Approved, Illicit, Withdrawn
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Clobazam.Approved
EthosuximideThe risk or severity of adverse effects can be increased when Clobazam is combined with Ethosuximide.Approved
EthotoinThe risk or severity of adverse effects can be increased when Clobazam is combined with Ethotoin.Approved
Ethyl carbamateThe risk or severity of adverse effects can be increased when Clobazam is combined with Ethyl carbamate.Withdrawn
Ethyl chlorideThe risk or severity of adverse effects can be increased when Clobazam is combined with Ethyl chloride.Approved, Experimental, Investigational
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Clobazam is combined with Ethyl loflazepate.Approved, Illicit
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Clobazam.Approved, Illicit
Ethynodiol diacetateThe serum concentration of Ethynodiol diacetate can be decreased when it is combined with Clobazam.Approved
EtidocaineThe risk or severity of adverse effects can be increased when Clobazam is combined with Etidocaine.Approved
EtifoxineThe risk or severity of adverse effects can be increased when Clobazam is combined with Etifoxine.Investigational, Withdrawn
EtizolamThe risk or severity of adverse effects can be increased when Clobazam is combined with Etizolam.Approved
EtomidateThe risk or severity of adverse effects can be increased when Clobazam is combined with Etomidate.Approved
EtonogestrelThe serum concentration of Etonogestrel can be decreased when it is combined with Clobazam.Approved, Investigational
EtoperidoneThe risk or severity of adverse effects can be increased when Clobazam is combined with Etoperidone.Withdrawn
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Clobazam.Approved, Investigational
EtorphineThe risk or severity of adverse effects can be increased when Clobazam is combined with Etorphine.Illicit, Vet Approved
EtravirineThe metabolism of Clobazam can be decreased when combined with Etravirine.Approved
EzogabineThe risk or severity of adverse effects can be increased when Clobazam is combined with Ezogabine.Approved, Investigational
FelbamateThe risk or severity of adverse effects can be increased when Clobazam is combined with Felbamate.Approved
FelodipineThe serum concentration of Clobazam can be increased when it is combined with Felodipine.Approved, Investigational
FencamfamineThe risk or severity of adverse effects can be increased when Clobazam is combined with Fencamfamine.Approved, Illicit, Withdrawn
FentanylThe risk or severity of adverse effects can be increased when Fentanyl is combined with Clobazam.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Clobazam.Approved
FexofenadineThe risk or severity of adverse effects can be increased when Clobazam is combined with Fexofenadine.Approved, Investigational
FingolimodThe metabolism of Fingolimod can be decreased when combined with Clobazam.Approved, Investigational
FlecainideThe metabolism of Flecainide can be decreased when combined with Clobazam.Approved, Withdrawn
FlibanserinThe risk or severity of adverse effects can be increased when Clobazam is combined with Flibanserin.Approved, Investigational
FluanisoneThe risk or severity of adverse effects can be increased when Clobazam is combined with Fluanisone.Experimental
FluconazoleThe metabolism of Clobazam can be decreased when combined with Fluconazole.Approved, Investigational
FludiazepamThe risk or severity of adverse effects can be increased when Clobazam is combined with Fludiazepam.Approved, Illicit
FlunarizineThe risk or severity of adverse effects can be increased when Clobazam is combined with Flunarizine.Approved
FlunitrazepamThe risk or severity of adverse effects can be increased when Clobazam is combined with Flunitrazepam.Approved, Illicit
FluoxetineThe risk or severity of adverse effects can be increased when Clobazam is combined with Fluoxetine.Approved, Vet Approved
FlupentixolThe risk or severity of adverse effects can be increased when Flupentixol is combined with Clobazam.Approved, Investigational, Withdrawn
FluphenazineThe metabolism of Fluphenazine can be decreased when combined with Clobazam.Approved
FlurazepamThe risk or severity of adverse effects can be increased when Flurazepam is combined with Clobazam.Approved, Illicit, Investigational
FluspirileneThe risk or severity of adverse effects can be increased when Clobazam is combined with Fluspirilene.Approved, Investigational
Fluticasone propionateThe risk or severity of adverse effects can be increased when Clobazam is combined with Fluticasone propionate.Approved
FluvoxamineThe risk or severity of adverse effects can be increased when Clobazam is combined with Fluvoxamine.Approved, Investigational
FormoterolThe metabolism of Formoterol can be decreased when combined with Clobazam.Approved, Investigational
FosamprenavirThe metabolism of Clobazam can be decreased when combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Clobazam can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinThe serum concentration of Fosphenytoin can be increased when it is combined with Clobazam.Approved, Investigational
FospropofolThe risk or severity of adverse effects can be increased when Clobazam is combined with Fospropofol.Approved, Illicit, Investigational
Fusidic AcidThe serum concentration of Clobazam can be increased when it is combined with Fusidic Acid.Approved, Investigational
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Clobazam.Approved, Investigational
Gabapentin EnacarbilThe risk or severity of adverse effects can be increased when Clobazam is combined with Gabapentin Enacarbil.Approved, Investigational
GalantamineThe metabolism of Galantamine can be decreased when combined with Clobazam.Approved
GallopamilThe serum concentration of Clobazam can be increased when it is combined with Gallopamil.Investigational
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Clobazam.Approved, Illicit, Investigational
GanciclovirThe therapeutic efficacy of Clobazam can be decreased when used in combination with Ganciclovir.Approved, Investigational
GefitinibThe metabolism of Gefitinib can be decreased when combined with Clobazam.Approved, Investigational
GemfibrozilThe metabolism of Clobazam can be decreased when combined with Gemfibrozil.Approved
GepironeThe risk or severity of adverse effects can be increased when Clobazam is combined with Gepirone.Investigational
GestodeneThe serum concentration of Gestodene can be decreased when it is combined with Clobazam.Approved, Investigational
GestrinoneThe serum concentration of Gestrinone can be decreased when it is combined with Clobazam.Approved
GlutethimideThe risk or severity of adverse effects can be increased when Clobazam is combined with Glutethimide.Approved, Illicit
GlyburideThe serum concentration of Clobazam can be increased when it is combined with Glyburide.Approved
GlycerinThe serum concentration of Clobazam can be increased when it is combined with Glycerin.Approved, Investigational
GranisetronThe metabolism of Granisetron can be decreased when combined with Clobazam.Approved, Investigational
GuanfacineThe risk or severity of adverse effects can be increased when Clobazam is combined with Guanfacine.Approved, Investigational
HalazepamThe risk or severity of adverse effects can be increased when Clobazam is combined with Halazepam.Approved, Illicit, Withdrawn
HalofantrineThe metabolism of Halofantrine can be decreased when combined with Clobazam.Approved
HaloperidolThe metabolism of Haloperidol can be decreased when combined with Clobazam.Approved
HalothaneThe metabolism of Halothane can be decreased when combined with Clobazam.Approved, Vet Approved
HeroinThe risk or severity of adverse effects can be increased when Clobazam is combined with Heroin.Approved, Illicit, Investigational
HexobarbitalThe risk or severity of adverse effects can be increased when Clobazam is combined with Hexobarbital.Approved
HyaluronidaseThe therapeutic efficacy of Clobazam can be decreased when used in combination with Hyaluronidase.Approved, Investigational
HydrocodoneClobazam may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.Approved, Illicit
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Clobazam.Approved, Illicit
Hydroxyprogesterone caproateThe serum concentration of Hydroxyprogesterone caproate can be decreased when it is combined with Clobazam.Approved, Investigational
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Clobazam.Approved
IbrutinibThe metabolism of Ibrutinib can be decreased when combined with Clobazam.Approved
IbuprofenThe serum concentration of Clobazam can be increased when it is combined with Ibuprofen.Approved
IdarubicinThe metabolism of Idarubicin can be decreased when combined with Clobazam.Approved
IdelalisibThe metabolism of Clobazam can be decreased when combined with Idelalisib.Approved
IloperidoneThe metabolism of Iloperidone can be decreased when combined with Clobazam.Approved
ImatinibThe metabolism of Clobazam can be decreased when combined with Imatinib.Approved
ImipramineThe metabolism of Imipramine can be decreased when combined with Clobazam.Approved
IndalpineThe risk or severity of adverse effects can be increased when Clobazam is combined with Indalpine.Investigational, Withdrawn
IndinavirThe metabolism of Clobazam can be decreased when combined with Indinavir.Approved
IndiplonThe risk or severity of adverse effects can be increased when Clobazam is combined with Indiplon.Investigational
IpecacThe metabolism of Ipecac can be decreased when combined with Clobazam.Approved, Withdrawn
IsavuconazoleThe serum concentration of Clobazam can be increased when it is combined with Isavuconazole.Approved, Investigational
IsavuconazoniumThe metabolism of Clobazam can be decreased when combined with Isavuconazonium.Approved, Investigational
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Clobazam.Approved, Vet Approved
IsoniazidThe metabolism of Clobazam can be decreased when combined with Isoniazid.Approved, Investigational
IsradipineThe serum concentration of Clobazam can be increased when it is combined with Isradipine.Approved, Investigational
ItraconazoleThe metabolism of Clobazam can be decreased when combined with Itraconazole.Approved, Investigational
IvacaftorThe serum concentration of Clobazam can be increased when it is combined with Ivacaftor.Approved
IxazomibThe metabolism of Ixazomib can be decreased when combined with Clobazam.Approved, Investigational
KetamineThe risk or severity of adverse effects can be increased when Ketamine is combined with Clobazam.Approved, Vet Approved
KetazolamThe risk or severity of adverse effects can be increased when Clobazam is combined with Ketazolam.Approved
KetobemidoneThe risk or severity of adverse effects can be increased when Clobazam is combined with Ketobemidone.Approved, Investigational
KetoconazoleThe metabolism of Clobazam can be decreased when combined with Ketoconazole.Approved, Investigational
LabetalolThe metabolism of Labetalol can be decreased when combined with Clobazam.Approved
LamotrigineThe risk or severity of adverse effects can be increased when Clobazam is combined with Lamotrigine.Approved, Investigational
LetermovirThe metabolism of Letermovir can be decreased when combined with Clobazam.Approved, Investigational
LevetiracetamThe risk or severity of adverse effects can be increased when Clobazam is combined with Levetiracetam.Approved, Investigational
LevobupivacaineThe risk or severity of adverse effects can be increased when Clobazam is combined with Levobupivacaine.Approved, Investigational
LevocabastineThe risk or severity of adverse effects can be increased when Clobazam is combined with Levocabastine.Approved, Investigational
LevocetirizineThe risk or severity of adverse effects can be increased when Clobazam is combined with Levocetirizine.Approved
LevodopaThe risk or severity of adverse effects can be increased when Clobazam is combined with Levodopa.Approved
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Clobazam is combined with Levomethadyl Acetate.Approved, Investigational
LevomilnacipranThe metabolism of Levomilnacipran can be decreased when combined with Clobazam.Approved, Investigational
LevonorgestrelThe serum concentration of Levonorgestrel can be decreased when it is combined with Clobazam.Approved, Investigational
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Clobazam.Approved
LidocaineThe serum concentration of Clobazam can be increased when it is combined with Lidocaine.Approved, Vet Approved
LisurideThe metabolism of Lisuride can be decreased when combined with Clobazam.Approved, Investigational
Lithium cationThe risk or severity of adverse effects can be increased when Clobazam is combined with Lithium.Experimental
LobeglitazoneThe metabolism of Clobazam can be decreased when combined with Lobeglitazone.Approved, Investigational
LofentanilThe risk or severity of adverse effects can be increased when Clobazam is combined with Lofentanil.Illicit
LofexidineThe therapeutic efficacy of Clobazam can be increased when used in combination with Lofexidine.Approved, Investigational
LomerizineThe serum concentration of Clobazam can be increased when it is combined with Lomerizine.Experimental
LomustineThe metabolism of Lomustine can be decreased when combined with Clobazam.Approved, Investigational
LoperamideThe serum concentration of Clobazam can be increased when it is combined with Loperamide.Approved
LopinavirThe metabolism of Clobazam can be decreased when combined with Lopinavir.Approved
LoprazolamThe risk or severity of adverse effects can be increased when Clobazam is combined with Loprazolam.Experimental
LoratadineThe risk or severity of adverse effects can be increased when Clobazam is combined with Loratadine.Approved, Investigational
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Clobazam.Approved
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Clobazam.Approved
LormetazepamThe risk or severity of adverse effects can be increased when Clobazam is combined with Lormetazepam.Approved
LorpiprazoleThe serum concentration of Clobazam can be increased when it is combined with Lorpiprazole.Approved
LosartanThe serum concentration of Clobazam can be increased when it is combined with Losartan.Approved
LovastatinThe metabolism of Clobazam can be decreased when combined with Lovastatin.Approved, Investigational
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Clobazam.Approved
LuliconazoleThe serum concentration of Clobazam can be increased when it is combined with Luliconazole.Approved
LumacaftorThe serum concentration of Clobazam can be decreased when it is combined with Lumacaftor.Approved
LurasidoneThe risk or severity of adverse effects can be increased when Lurasidone is combined with Clobazam.Approved, Investigational
LynestrenolThe serum concentration of Lynestrenol can be decreased when it is combined with Clobazam.Approved, Investigational
Magnesium carbonateThe risk or severity of adverse effects can be increased when Clobazam is combined with Magnesium carbonate.Approved, Investigational
Magnesium citrateThe risk or severity of adverse effects can be increased when Clobazam is combined with Magnesium citrate.Approved
Magnesium hydroxideThe risk or severity of adverse effects can be increased when Clobazam is combined with Magnesium hydroxide.Approved, Investigational
Magnesium sulfateThe therapeutic efficacy of Clobazam can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Vet Approved
Magnesium TrisilicateThe risk or severity of adverse effects can be increased when Clobazam is combined with Magnesium Trisilicate.Approved
MaprotilineThe metabolism of Maprotiline can be decreased when combined with Clobazam.Approved, Investigational
MebicarThe risk or severity of adverse effects can be increased when Clobazam is combined with Mebicar.Experimental
MeclizineThe risk or severity of adverse effects can be increased when Clobazam is combined with Meclizine.Approved
MedazepamThe risk or severity of adverse effects can be increased when Clobazam is combined with Medazepam.Experimental
MedetomidineThe risk or severity of adverse effects can be increased when Clobazam is combined with Medetomidine.Vet Approved
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with Clobazam.Approved, Investigational
MefloquineThe therapeutic efficacy of Clobazam can be decreased when used in combination with Mefloquine.Approved, Investigational
Megestrol acetateThe serum concentration of Megestrol acetate can be decreased when it is combined with Clobazam.Approved, Investigational, Vet Approved
MelatoninThe risk or severity of adverse effects can be increased when Clobazam is combined with Melatonin.Approved, Nutraceutical, Vet Approved
MelperoneThe risk or severity of adverse effects can be increased when Clobazam is combined with Melperone.Approved, Investigational
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Clobazam.Investigational, Withdrawn
MepivacaineThe risk or severity of adverse effects can be increased when Clobazam is combined with Mepivacaine.Approved, Vet Approved
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Clobazam.Approved, Illicit
MeptazinolThe risk or severity of adverse effects can be increased when Clobazam is combined with Meptazinol.Experimental
MequitazineThe metabolism of Mequitazine can be decreased when combined with Clobazam.Approved
MesoridazineThe metabolism of Mesoridazine can be decreased when combined with Clobazam.Approved, Investigational
MestranolThe serum concentration of Mestranol can be decreased when it is combined with Clobazam.Approved
MetaxaloneThe risk or severity of adverse effects can be increased when Clobazam is combined with Metaxalone.Approved
MethadoneClobazam may increase the central nervous system depressant (CNS depressant) activities of Methadone.Approved
Methadyl AcetateThe risk or severity of adverse effects can be increased when Clobazam is combined with Methadyl Acetate.Approved, Illicit
MethamphetamineThe metabolism of Methamphetamine can be decreased when combined with Clobazam.Approved, Illicit
MethapyrileneThe risk or severity of adverse effects can be increased when Clobazam is combined with Methapyrilene.Withdrawn
MethaqualoneThe risk or severity of adverse effects can be increased when Clobazam is combined with Methaqualone.Illicit, Withdrawn
MethocarbamolThe risk or severity of adverse effects can be increased when Clobazam is combined with Methocarbamol.Approved, Vet Approved
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Clobazam.Approved
MethotrimeprazineClobazam may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.Approved, Investigational
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Clobazam.Approved, Investigational, Vet Approved
MethsuximideThe risk or severity of adverse effects can be increased when Clobazam is combined with Methsuximide.Approved
MethylecgonineThe risk or severity of adverse effects can be increased when Clobazam is combined with Methylecgonine.Experimental
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Clobazam is combined with Methylphenobarbital.Approved
MethyprylonThe metabolism of Methyprylon can be decreased when combined with Clobazam.Approved, Illicit, Withdrawn
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Clobazam.Approved, Investigational
MetyrosineClobazam may increase the sedative activities of Metyrosine.Approved
MexiletineThe metabolism of Mexiletine can be decreased when combined with Clobazam.Approved, Investigational
MianserinThe therapeutic efficacy of Clobazam can be decreased when used in combination with Mianserin.Approved, Investigational
MibefradilThe metabolism of Clobazam can be decreased when combined with Mibefradil.Investigational, Withdrawn
MiconazoleThe serum concentration of Clobazam can be increased when it is combined with Miconazole.Approved, Investigational, Vet Approved
MidazolamThe risk or severity of adverse effects can be increased when Midazolam is combined with Clobazam.Approved, Illicit
MifepristoneThe serum concentration of Clobazam can be increased when it is combined with Mifepristone.Approved, Investigational
MilnacipranThe risk or severity of adverse effects can be increased when Clobazam is combined with Milnacipran.Approved, Investigational
MinaprineThe metabolism of Minaprine can be decreased when combined with Clobazam.Approved
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Clobazam.Approved, Investigational
MirabegronThe metabolism of Mirabegron can be decreased when combined with Clobazam.Approved
MirtazapineClobazam may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.Approved
MitotaneThe serum concentration of Clobazam can be decreased when it is combined with Mitotane.Approved
MoclobemideThe metabolism of Moclobemide can be decreased when combined with Clobazam.Approved, Investigational
ModafinilThe metabolism of Clobazam can be decreased when combined with Modafinil.Approved, Investigational
MolindoneThe risk or severity of adverse effects can be increased when Clobazam is combined with Molindone.Approved
MorphineThe metabolism of Morphine can be decreased when combined with Clobazam.Approved, Investigational
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Clobazam.Approved, Investigational
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Clobazam.Approved
NateglinideThe metabolism of Nateglinide can be decreased when combined with Clobazam.Approved, Investigational
NebivololThe serum concentration of Nebivolol can be increased when it is combined with Clobazam.Approved, Investigational
NefazodoneThe metabolism of Clobazam can be decreased when combined with Nefazodone.Approved, Withdrawn
NelfinavirThe metabolism of Clobazam can be decreased when combined with Nelfinavir.Approved
NeomycinThe risk or severity of adverse effects can be increased when Clobazam is combined with Neomycin.Approved, Vet Approved
NetupitantThe serum concentration of Clobazam can be increased when it is combined with Netupitant.Approved, Investigational
NevirapineThe metabolism of Clobazam can be increased when combined with Nevirapine.Approved
NicardipineThe serum concentration of Clobazam can be increased when it is combined with Nicardipine.Approved, Investigational
NicergolineThe metabolism of Nicergoline can be decreased when combined with Clobazam.Approved, Investigational
NifedipineThe metabolism of Nifedipine can be decreased when combined with Clobazam.Approved
NiguldipineThe serum concentration of Clobazam can be increased when it is combined with Niguldipine.Experimental
NilotinibThe metabolism of Clobazam can be decreased when combined with Nilotinib.Approved, Investigational
NimodipineThe serum concentration of Clobazam can be increased when it is combined with Nimodipine.Approved, Investigational
NisoldipineThe serum concentration of Clobazam can be increased when it is combined with Nisoldipine.Approved
NitrazepamThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Clobazam.Approved
NitrendipineThe serum concentration of Clobazam can be increased when it is combined with Nitrendipine.Approved, Investigational
NitrofuralThe metabolism of Nitrofural can be decreased when combined with Clobazam.Approved, Investigational, Vet Approved
Nitrous oxideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Clobazam.Approved, Vet Approved
Nomegestrol acetateThe serum concentration of Nomegestrol acetate can be decreased when it is combined with Clobazam.Approved, Investigational
NordazepamThe risk or severity of adverse effects can be increased when Clobazam is combined with Nordazepam.Approved
NorelgestrominThe serum concentration of Norelgestromin can be decreased when it is combined with Clobazam.Approved, Investigational
NorethisteroneThe serum concentration of Norethisterone can be decreased when it is combined with Clobazam.Approved
NorethynodrelThe serum concentration of Norethynodrel can be decreased when it is combined with Clobazam.Approved
NorfluraneThe risk or severity of adverse effects can be increased when Clobazam is combined with Norflurane.Approved, Investigational
NorgestimateThe serum concentration of Norgestimate can be decreased when it is combined with Clobazam.Approved, Investigational
NorgestrelThe serum concentration of Norgestrel can be decreased when it is combined with Clobazam.Approved
NorgestrienoneThe serum concentration of Norgestrienone can be decreased when it is combined with Clobazam.Experimental
NormethadoneThe risk or severity of adverse effects can be increased when Clobazam is combined with Normethadone.Approved, Illicit
NortriptylineThe metabolism of Nortriptyline can be decreased when combined with Clobazam.Approved
OlanzapineThe risk or severity of adverse effects can be increased when Clobazam is combined with Olanzapine.Approved, Investigational
OlaparibThe metabolism of Clobazam can be decreased when combined with Olaparib.Approved
OlopatadineThe risk or severity of adverse effects can be increased when Clobazam is combined with Olopatadine.Approved
OmeprazoleThe serum concentration of Clobazam can be increased when it is combined with Omeprazole.Approved, Investigational, Vet Approved
OndansetronThe risk or severity of adverse effects can be increased when Clobazam is combined with Ondansetron.Approved
OpiumThe risk or severity of adverse effects can be increased when Clobazam is combined with Opium.Approved, Illicit
OrlistatThe serum concentration of Clobazam can be decreased when it is combined with Orlistat.Approved, Investigational
OrphenadrineClobazam may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.Approved
OsanetantThe risk or severity of adverse effects can be increased when Clobazam is combined with Osanetant.Investigational
OsimertinibThe serum concentration of Clobazam can be increased when it is combined with Osimertinib.Approved
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with Clobazam.Approved
OxprenololThe risk or severity of adverse effects can be increased when Clobazam is combined with Oxprenolol.Approved
OxybuprocaineThe risk or severity of adverse effects can be increased when Clobazam is combined with Oxybuprocaine.Approved, Investigational
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Clobazam.Approved, Illicit, Investigational
OxymorphoneThe risk or severity of adverse effects can be increased when Oxymorphone is combined with Clobazam.Approved, Investigational, Vet Approved
PalbociclibThe serum concentration of Clobazam can be increased when it is combined with Palbociclib.Approved, Investigational
PaliperidoneThe risk or severity of adverse effects can be increased when Paliperidone is combined with Clobazam.Approved
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Clobazam.Approved, Investigational
ParaldehydeClobazam may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
ParomomycinThe risk or severity of adverse effects can be increased when Clobazam is combined with Paromomycin.Approved, Investigational
ParoxetineThe risk or severity of adverse effects can be increased when Clobazam is combined with Paroxetine.Approved, Investigational
PazopanibThe metabolism of Pazopanib can be decreased when combined with Clobazam.Approved
PenfluridolThe risk or severity of adverse effects can be increased when Clobazam is combined with Penfluridol.Experimental
PentamidineThe metabolism of Pentamidine can be decreased when combined with Clobazam.Approved, Investigational
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Clobazam.Approved, Vet Approved
PentobarbitalThe metabolism of Clobazam can be increased when combined with Pentobarbital.Approved, Investigational, Vet Approved
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Clobazam.Approved
PerazineThe risk or severity of adverse effects can be increased when Clobazam is combined with Perazine.Approved, Investigational
PerospironeThe metabolism of Perospirone can be decreased when combined with Clobazam.Approved
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Clobazam.Approved
PethidineThe metabolism of Pethidine can be decreased when combined with Clobazam.Approved
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Clobazam.Withdrawn
PhenazocineThe risk or severity of adverse effects can be increased when Clobazam is combined with Phenazocine.Experimental
PhenforminThe metabolism of Phenformin can be decreased when combined with Clobazam.Approved, Investigational, Withdrawn
PhenibutThe risk or severity of adverse effects can be increased when Clobazam is combined with Phenibut.Experimental
PhenobarbitalThe metabolism of Clobazam can be increased when combined with Phenobarbital.Approved, Investigational
PhenoperidineThe risk or severity of adverse effects can be increased when Clobazam is combined with Phenoperidine.Experimental
PhenoxyethanolThe risk or severity of adverse effects can be increased when Clobazam is combined with Phenoxyethanol.Approved
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Clobazam.Approved, Vet Approved
PimozideThe risk or severity of adverse effects can be increased when Pimozide is combined with Clobazam.Approved
PindololThe metabolism of Pindolol can be decreased when combined with Clobazam.Approved, Investigational
PipamperoneThe risk or severity of adverse effects can be increased when Clobazam is combined with Pipamperone.Approved, Investigational
PiperazineThe metabolism of Piperazine can be decreased when combined with Clobazam.Approved, Vet Approved
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Clobazam.Approved, Investigational
PiritramideThe risk or severity of adverse effects can be increased when Clobazam is combined with Piritramide.Approved, Investigational
PitolisantThe serum concentration of Pitolisant can be increased when it is combined with Clobazam.Approved, Investigational
PizotifenThe risk or severity of adverse effects can be increased when Clobazam is combined with Pizotifen.Approved
Polymyxin B SulfateThe risk or severity of adverse effects can be increased when Clobazam is combined with Polymyxin B Sulfate.Approved, Vet Approved
PomalidomideThe risk or severity of adverse effects can be increased when Clobazam is combined with Pomalidomide.Approved
PonatinibThe metabolism of Ponatinib can be decreased when combined with Clobazam.Approved, Investigational
PosaconazoleThe metabolism of Clobazam can be decreased when combined with Posaconazole.Approved, Investigational, Vet Approved
PramipexoleClobazam may increase the sedative activities of Pramipexole.Approved, Investigational
PrazepamThe risk or severity of adverse effects can be increased when Clobazam is combined with Prazepam.Approved, Illicit
PregabalinThe therapeutic efficacy of Clobazam can be increased when used in combination with Pregabalin.Approved, Illicit, Investigational
PrilocaineThe risk or severity of adverse effects can be increased when Clobazam is combined with Prilocaine.Approved
PrimidoneThe metabolism of Clobazam can be increased when combined with Primidone.Approved, Vet Approved
ProcainamideThe metabolism of Procainamide can be decreased when combined with Clobazam.Approved
ProcaineThe risk or severity of adverse effects can be increased when Clobazam is combined with Procaine.Approved, Investigational, Vet Approved
ProchlorperazineThe risk or severity of adverse effects can be increased when Prochlorperazine is combined with Clobazam.Approved, Vet Approved
ProgesteroneThe metabolism of Progesterone can be decreased when combined with Clobazam.Approved, Vet Approved
PromazineThe risk or severity of adverse effects can be increased when Promazine is combined with Clobazam.Approved, Vet Approved
PromethazineThe risk or severity of adverse effects can be increased when Clobazam is combined with Promethazine.Approved, Investigational
PropanididThe risk or severity of adverse effects can be increased when Clobazam is combined with Propanidid.Experimental
ProparacaineThe risk or severity of adverse effects can be increased when Clobazam is combined with Proparacaine.Approved, Vet Approved
PropofolThe metabolism of Propofol can be decreased when combined with Clobazam.Approved, Investigational, Vet Approved
PropoxycaineThe risk or severity of adverse effects can be increased when Clobazam is combined with Propoxycaine.Approved
PropranololThe metabolism of Propranolol can be decreased when combined with Clobazam.Approved, Investigational
ProtriptylineThe metabolism of Protriptyline can be decreased when combined with Clobazam.Approved
ProxibarbalThe risk or severity of adverse effects can be increased when Clobazam is combined with Proxibarbal.Experimental
PSD502The risk or severity of adverse effects can be increased when Clobazam is combined with PSD502.Investigational
PseudoephedrineThe risk or severity of adverse effects can be increased when Clobazam is combined with Pseudoephedrine.Approved
PyrantelThe risk or severity of adverse effects can be increased when Clobazam is combined with Pyrantel.Approved, Vet Approved
QuazepamThe serum concentration of Clobazam can be increased when it is combined with Quazepam.Approved, Illicit
QuetiapineThe risk or severity of adverse effects can be increased when Quetiapine is combined with Clobazam.Approved
QuingestanolThe serum concentration of Quingestanol can be decreased when it is combined with Clobazam.Experimental
QuinineThe metabolism of Quinine can be decreased when combined with Clobazam.Approved
QuinisocaineThe risk or severity of adverse effects can be increased when Clobazam is combined with Quinisocaine.Experimental
RacloprideThe risk or severity of adverse effects can be increased when Clobazam is combined with Raclopride.Investigational
RamelteonThe risk or severity of adverse effects can be increased when Clobazam is combined with Ramelteon.Approved, Investigational
RanitidineThe serum concentration of Clobazam can be increased when it is combined with Ranitidine.Approved
RanolazineThe serum concentration of Clobazam can be increased when it is combined with Ranolazine.Approved, Investigational
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Clobazam.Approved
RemoxiprideThe metabolism of Remoxipride can be decreased when combined with Clobazam.Approved, Withdrawn
RepinotanThe metabolism of Repinotan can be decreased when combined with Clobazam.Investigational
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Clobazam.Approved, Investigational
RifabutinThe metabolism of Clobazam can be increased when combined with Rifabutin.Approved, Investigational
RifampicinThe metabolism of Clobazam can be increased when combined with Rifampicin.Approved
RifapentineThe metabolism of Clobazam can be increased when combined with Rifapentine.Approved, Investigational
RilpivirineThe serum concentration of Rilpivirine can be decreased when it is combined with Clobazam.Approved
RisperidoneThe metabolism of Risperidone can be decreased when combined with Clobazam.Approved, Investigational
RitanserinThe risk or severity of adverse effects can be increased when Clobazam is combined with Ritanserin.Investigational
RitonavirThe metabolism of Ritonavir can be decreased when combined with Clobazam.Approved, Investigational
RizatriptanThe risk or severity of adverse effects can be increased when Clobazam is combined with Rizatriptan.Approved
RomifidineThe risk or severity of adverse effects can be increased when Clobazam is combined with Romifidine.Vet Approved
RopiniroleClobazam may increase the sedative activities of Ropinirole.Approved, Investigational
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Clobazam.Approved
RotigotineClobazam may increase the sedative activities of Rotigotine.Approved
RucaparibThe metabolism of Rucaparib can be decreased when combined with Clobazam.Approved, Investigational
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Clobazam.Approved
RupatadineThe metabolism of Rupatadine can be decreased when combined with Clobazam.Approved
SaquinavirThe metabolism of Clobazam can be decreased when combined with Saquinavir.Approved, Investigational
SarilumabThe therapeutic efficacy of Clobazam can be decreased when used in combination with Sarilumab.Approved, Investigational
ScopolamineThe risk or severity of adverse effects can be increased when Clobazam is combined with Scopolamine.Approved, Investigational
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Clobazam.Approved, Vet Approved
SepranoloneThe risk or severity of adverse effects can be increased when Clobazam is combined with Sepranolone.Investigational
SertindoleThe metabolism of Sertindole can be decreased when combined with Clobazam.Approved, Investigational, Withdrawn
SertralineThe metabolism of Sertraline can be decreased when combined with Clobazam.Approved
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Clobazam.Approved, Vet Approved
SildenafilThe metabolism of Clobazam can be decreased when combined with Sildenafil.Approved, Investigational
SiltuximabThe serum concentration of Clobazam can be decreased when it is combined with Siltuximab.Approved, Investigational
SimeprevirThe serum concentration of Clobazam can be increased when it is combined with Simeprevir.Approved
SimvastatinThe metabolism of Simvastatin can be decreased when combined with Clobazam.Approved
Sodium oxybateClobazam may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.Approved
SorafenibThe metabolism of Clobazam can be decreased when combined with Sorafenib.Approved, Investigational
SparteineThe metabolism of Sparteine can be decreased when combined with Clobazam.Experimental
St. John's WortThe serum concentration of Clobazam can be decreased when it is combined with St. John's Wort.Approved, Investigational, Nutraceutical
StiripentolThe serum concentration of Stiripentol can be increased when it is combined with Clobazam.Approved
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Clobazam.Approved, Investigational
SulfisoxazoleThe metabolism of Clobazam can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
SulpirideThe risk or severity of adverse effects can be increased when Clobazam is combined with Sulpiride.Approved, Investigational
SultoprideThe risk or severity of adverse effects can be increased when Clobazam is combined with Sultopride.Experimental
SumatriptanThe risk or severity of adverse effects can be increased when Clobazam is combined with Sumatriptan.Approved, Investigational
SuvorexantClobazam may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.Approved, Investigational
TamoxifenThe serum concentration of the active metabolites of Tamoxifen can be reduced when Tamoxifen is used in combination with Clobazam resulting in a loss in efficacy.Approved
TamsulosinThe metabolism of Tamsulosin can be decreased when combined with Clobazam.Approved, Investigational
TandospironeThe risk or severity of adverse effects can be increased when Clobazam is combined with Tandospirone.Investigational
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Clobazam.Approved
TasimelteonThe risk or severity of adverse effects can be increased when Clobazam is combined with Tasimelteon.Approved, Investigational
TeduglutideThe serum concentration of Clobazam can be increased when it is combined with Teduglutide.Approved
TegaserodThe metabolism of Tegaserod can be decreased when combined with Clobazam.Approved, Investigational, Withdrawn
TelaprevirThe metabolism of Clobazam can be decreased when combined with Telaprevir.Approved, Withdrawn
TelithromycinThe metabolism of Clobazam can be decreased when combined with Telithromycin.Approved
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Clobazam.Approved, Investigational
TerfenadineThe metabolism of Terfenadine can be decreased when combined with Clobazam.Approved, Withdrawn
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Clobazam.Investigational
TetrabenazineThe metabolism of Tetrabenazine can be decreased when combined with Clobazam.Approved, Investigational
TetracaineThe risk or severity of adverse effects can be increased when Clobazam is combined with Tetracaine.Approved, Vet Approved
TetracyclineThe risk or severity of adverse effects can be increased when Clobazam is combined with Tetracycline.Approved, Vet Approved
TetrahydropalmatineThe risk or severity of adverse effects can be increased when Clobazam is combined with Tetrahydropalmatine.Investigational
TetrandrineThe serum concentration of Clobazam can be increased when it is combined with Tetrandrine.Experimental
TetrodotoxinThe risk or severity of adverse effects can be increased when Clobazam is combined with Tetrodotoxin.Investigational
ThalidomideClobazam may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.Approved, Investigational, Withdrawn
TheophyllineThe therapeutic efficacy of Clobazam can be decreased when used in combination with Theophylline.Approved
ThiamylalThe risk or severity of adverse effects can be increased when Clobazam is combined with Thiamylal.Approved, Vet Approved
ThiopentalThe risk or severity of adverse effects can be increased when Clobazam is combined with Thiopental.Approved, Vet Approved
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Clobazam.Approved, Withdrawn
ThiotepaThe metabolism of Clobazam can be decreased when combined with Thiotepa.Approved, Investigational
ThiothixeneThe risk or severity of adverse effects can be increased when Thiothixene is combined with Clobazam.Approved
TiagabineThe risk or severity of adverse effects can be increased when Clobazam is combined with Tiagabine.Approved, Investigational
TiaprideThe risk or severity of adverse effects can be increased when Clobazam is combined with Tiapride.Approved, Investigational
TiclopidineThe metabolism of Clobazam can be decreased when combined with Ticlopidine.Approved
TiletamineThe risk or severity of adverse effects can be increased when Clobazam is combined with Tiletamine.Vet Approved
TilidineThe risk or severity of adverse effects can be increased when Clobazam is combined with Tilidine.Experimental
TimololThe metabolism of Timolol can be decreased when combined with Clobazam.Approved
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Clobazam.Approved
TipranavirThe metabolism of Tipranavir can be decreased when combined with Clobazam.Approved, Investigational
TizanidineThe risk or severity of adverse effects can be increased when Clobazam is combined with Tizanidine.Approved, Investigational
TocilizumabThe serum concentration of Clobazam can be decreased when it is combined with Tocilizumab.Approved
TolcaponeThe risk or severity of adverse effects can be increased when Tolcapone is combined with Clobazam.Approved, Withdrawn
TolterodineThe metabolism of Tolterodine can be decreased when combined with Clobazam.Approved, Investigational
TopiramateThe risk or severity of adverse effects can be increased when Topiramate is combined with Clobazam.Approved
TrabectedinThe metabolism of Trabectedin can be decreased when combined with Clobazam.Approved, Investigational
TramadolThe therapeutic efficacy of Tramadol can be decreased when used in combination with Clobazam.Approved, Investigational
TranylcypromineThe metabolism of Clobazam can be decreased when combined with Tranylcypromine.Approved, Investigational
TrazodoneThe metabolism of Trazodone can be decreased when combined with Clobazam.Approved, Investigational
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with Clobazam.Approved, Investigational
Tricaine methanesulfonateThe risk or severity of adverse effects can be increased when Clobazam is combined with Tricaine methanesulfonate.Vet Approved
TrichloroethyleneThe risk or severity of adverse effects can be increased when Clobazam is combined with Trichloroethylene.Approved
TrifluoperazineThe risk or severity of adverse effects can be increased when Trifluoperazine is combined with Clobazam.Approved, Investigational
TrifluperidolThe risk or severity of adverse effects can be increased when Clobazam is combined with Trifluperidol.Experimental
TriflupromazineThe risk or severity of adverse effects can be increased when Clobazam is combined with Triflupromazine.Approved, Vet Approved
TrimethadioneThe risk or severity of adverse effects can be increased when Clobazam is combined with Trimethadione.Approved
TrimipramineThe metabolism of Trimipramine can be decreased when combined with Clobazam.Approved
TriprolidineThe risk or severity of adverse effects can be increased when Clobazam is combined with Triprolidine.Approved
UlipristalThe serum concentration of Ulipristal can be decreased when it is combined with Clobazam.Approved
UmeclidiniumThe metabolism of Umeclidinium can be decreased when combined with Clobazam.Approved
ValaciclovirThe therapeutic efficacy of Clobazam can be decreased when used in combination with Valaciclovir.Approved, Investigational
ValbenazineThe metabolism of Valbenazine can be decreased when combined with Clobazam.Approved, Investigational
Valproic AcidThe risk or severity of adverse effects can be increased when Clobazam is combined with Valproic Acid.Approved, Investigational
VancomycinThe risk or severity of adverse effects can be increased when Clobazam is combined with Vancomycin.Approved
VecuroniumThe risk or severity of adverse effects can be increased when Clobazam is combined with Vecuronium.Approved
VemurafenibThe serum concentration of Clobazam can be increased when it is combined with Vemurafenib.Approved
VenlafaxineThe risk or severity of adverse effects can be increased when Clobazam is combined with Venlafaxine.Approved
VeraliprideThe risk or severity of adverse effects can be increased when Clobazam is combined with Veralipride.Experimental
VerapamilThe serum concentration of Clobazam can be increased when it is combined with Verapamil.Approved
VernakalantThe metabolism of Vernakalant can be decreased when combined with Clobazam.Approved, Investigational
VigabatrinThe risk or severity of adverse effects can be increased when Clobazam is combined with Vigabatrin.Approved
VilazodoneThe metabolism of Vilazodone can be decreased when combined with Clobazam.Approved
VinblastineThe metabolism of Vinblastine can be decreased when combined with Clobazam.Approved
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Clobazam.Approved, Investigational
VinpocetineThe risk or severity of adverse effects can be increased when Clobazam is combined with Vinpocetine.Investigational
Vinyl etherThe risk or severity of adverse effects can be increased when Clobazam is combined with Vinyl ether.Experimental
VoriconazoleThe metabolism of Clobazam can be decreased when combined with Voriconazole.Approved, Investigational
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Clobazam.Approved, Investigational
XenonThe risk or severity of adverse effects can be increased when Clobazam is combined with Xenon.Experimental
XylazineThe risk or severity of adverse effects can be increased when Clobazam is combined with Xylazine.Vet Approved
YohimbineThe therapeutic efficacy of Clobazam can be decreased when used in combination with Yohimbine.Approved, Investigational, Vet Approved
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Clobazam.Approved, Investigational
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with Clobazam.Approved, Illicit, Investigational
ZiconotideThe risk or severity of adverse effects can be increased when Clobazam is combined with Ziconotide.Approved
ZimelidineThe risk or severity of adverse effects can be increased when Clobazam is combined with Zimelidine.Withdrawn
ZiprasidoneThe metabolism of Clobazam can be decreased when combined with Ziprasidone.Approved
ZolazepamThe risk or severity of adverse effects can be increased when Clobazam is combined with Zolazepam.Vet Approved
ZolmitriptanThe risk or severity of adverse effects can be increased when Clobazam is combined with Zolmitriptan.Approved, Investigational
ZolpidemClobazam may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.Approved
ZonisamideThe risk or severity of adverse effects can be increased when Clobazam is combined with Zonisamide.Approved, Investigational
ZopicloneThe risk or severity of adverse effects can be increased when Zopiclone is combined with Clobazam.Approved
ZotepineThe risk or severity of adverse effects can be increased when Clobazam is combined with Zotepine.Approved, Investigational, Withdrawn
ZucapsaicinThe metabolism of Clobazam can be decreased when combined with Zucapsaicin.Approved, Investigational
ZuclopenthixolThe metabolism of Zuclopenthixol can be decreased when combined with Clobazam.Approved, Investigational
Food Interactions
  • Alcohol increases clobazam absorption by 50%.
  • Take without regard to meals.

References

Synthesis Reference

Hauptmann, K.H., Weber, K.-H., Zeile, K., Danneberg, P. and Giesemann, R.; South African Patent 68/0803; February 7,1968; assigned to Boehringer lngelheim GmbH, Germany.

General References
  1. Freche C: [Study of an anxiolytic, clobazam, in otorhinolaryngology in psychosomatic pharyngeal manifestations]. Sem Hop Ther. 1975 Apr;51(4):261-3. [PubMed:5777]
  2. Authors unspecified: Clobazam in treatment of refractory epilepsy: the Canadian experience. A retrospective study. Canadian Clobazam Cooperative Group. Epilepsia. 1991 May-Jun;32(3):407-16. [PubMed:2044502]
  3. Wildin JD, Pleuvry BJ, Mawer GE, Onon T, Millington L: Respiratory and sedative effects of clobazam and clonazepam in volunteers. Br J Clin Pharmacol. 1990 Feb;29(2):169-77. [PubMed:2106335]
  4. Kilpatrick C, Bury R, Fullinfaw R, Moulds R: Clobazam in the treatment of epilepsy. Clin Exp Neurol. 1987;23:139-44. [PubMed:3117456]
  5. Giarratano M, Standley K, Benbadis SR: Clobazam for treatment of epilepsy. Expert Opin Pharmacother. 2012 Feb;13(2):227-33. doi: 10.1517/14656566.2012.647686. Epub 2012 Jan 13. [PubMed:22242724]
  6. Yang LP, Scott LJ: Clobazam : in patients with Lennox-Gastaut syndrome. CNS Drugs. 2012 Nov;26(11):983-91. doi: 10.1007/s40263-012-0007-0. [PubMed:23034582]
  7. Walzer M, Bekersky I, Blum RA, Tolbert D: Pharmacokinetic drug interactions between clobazam and drugs metabolized by cytochrome P450 isoenzymes. Pharmacotherapy. 2012 Apr;32(4):340-53. doi: 10.1002/j.1875-9114.2012.01028.x. Epub 2012 Mar 15. [PubMed:22422635]
External Links
Human Metabolome Database
HMDB0014493
KEGG Drug
D01253
PubChem Compound
2789
PubChem Substance
46506115
ChemSpider
2687
ChEBI
31413
ChEMBL
CHEMBL70418
Therapeutic Targets Database
DAP000672
PharmGKB
PA10888
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
Wikipedia
Clobazam
ATC Codes
N05BA09 — Clobazam
AHFS Codes
  • 28:12.08 — Benzodiazepines
FDA label
Download (595 KB)
MSDS
Download (57.5 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1, 2CompletedBasic SciencePain, Neuropathic1
2CompletedTreatmentEpilepsies / Epilepsy, Generalized / Seizures1
3CompletedBasic ScienceLow Back Pain (LBP)1
3CompletedTreatmentEpilepsies / Epilepsy, Generalized / Seizures1
3CompletedTreatmentLennox-Gastaut Syndrome (LGS)1
3CompletedTreatmentPain1
3TerminatedTreatmentAnxiety Disorders / Dementias / Depression / Psychosomatic Disorders / Schizophrenic Disorders1
3TerminatedTreatmentDravet Syndrome1
3TerminatedTreatmentEpilepsia Partialis Continua / Epilepsies / Kojewnikov's Epilepsy1
3WithdrawnTreatmentDravet Syndrome1
4Active Not RecruitingTreatmentRefractory Epilepsy1
4RecruitingTreatmentEpilepsies2
4RecruitingTreatmentEpilepsies / Feeling Anxious1
Not AvailableRecruitingNot AvailableEpilepsies1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
TabletOral10 mg
SuspensionOral2.5 mg/mL
TabletOral10 mg/1
TabletOral20 mg/1
TabletOral5 mg/1
Prices
Unit descriptionCostUnit
Apo-Clobazam 10 mg Tablet0.23USD tablet
Novo-Clobazam 10 mg Tablet0.23USD tablet
Pms-Clobazam 10 mg Tablet0.23USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)180-182Hauptmann, K.H., Weber, K.-H., Zeile, K., Danneberg, P. and Giesemann, R.; South African Patent 68/0803; February 7,1968; assigned to Boehringer lngelheim GmbH, Germany.
water solubility188 mg/LNot Available
logP2.12HENCZI,M ET AL. (1995)
Predicted Properties
PropertyValueSource
Water Solubility0.164 mg/mLALOGPS
logP2.14ALOGPS
logP2.55ChemAxon
logS-3.3ALOGPS
pKa (Strongest Acidic)4.07ChemAxon
pKa (Strongest Basic)-6.7ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area40.62 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity80.3 m3·mol-1ChemAxon
Polarizability30.07 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.99
Blood Brain Barrier+0.9904
Caco-2 permeable+0.7487
P-glycoprotein substrateNon-substrate0.5733
P-glycoprotein inhibitor INon-inhibitor0.5462
P-glycoprotein inhibitor IINon-inhibitor0.9204
Renal organic cation transporterNon-inhibitor0.7373
CYP450 2C9 substrateNon-substrate0.7058
CYP450 2D6 substrateNon-substrate0.8607
CYP450 3A4 substrateSubstrate0.6871
CYP450 1A2 substrateNon-inhibitor0.6829
CYP450 2C9 inhibitorNon-inhibitor0.5296
CYP450 2D6 inhibitorNon-inhibitor0.8908
CYP450 2C19 inhibitorNon-inhibitor0.5791
CYP450 3A4 inhibitorInhibitor0.7008
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.5308
Ames testNon AMES toxic0.9132
CarcinogenicityNon-carcinogens0.7846
BiodegradationNot ready biodegradable1.0
Rat acute toxicity1.7313 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9896
hERG inhibition (predictor II)Non-inhibitor0.8651
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Download (11.4 KB)
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Mass Spectrum (Electron Ionization)MSsplash10-0pb9-6392000000-a76f30f353b3407df0c6
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-0a4i-0090000000-3b46d60abcc8dfacf4d8
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-0udi-0019000000-71512d7a18cf60430dd9
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-0a4i-0092000000-e687a1e3760fb870dbc9
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-0a4i-0090000000-d450ded1f22039f00b63
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-0ab9-0190000000-e4211cbc2957a587e3d3
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-05fr-0590000000-51f4fa0445c2d047ef6b
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-0g4j-1960000000-a89e1c91bfa7b974be48
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-014j-4920000000-93c0877b3acf519d2b98
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-016u-7900000000-bc29714be08b6ae4120b
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-0hi6-9600000000-7c6a3974d95a0015757e

Taxonomy

Description
This compound belongs to the class of organic compounds known as benzodiazepines. These are organic compounds containing a benzene ring fused to either isomers of diazepine(unsaturated seven-member heterocycle with two nitrogen atoms replacing two carbon atoms).
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Benzodiazepines
Sub Class
Not Available
Direct Parent
Benzodiazepines
Alternative Parents
1,4-diazepines / Benzene and substituted derivatives / Aryl chlorides / 1,3-dicarbonyl compounds / Tertiary carboxylic acid amides / Lactams / Azacyclic compounds / Organopnictogen compounds / Organonitrogen compounds / Organochlorides
show 2 more
Substituents
Benzodiazepine / Para-diazepine / Aryl chloride / Aryl halide / Monocyclic benzene moiety / 1,3-dicarbonyl compound / Benzenoid / Tertiary carboxylic acid amide / Lactam / Carboxamide group
show 13 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
organochlorine compound, 1,4-benzodiazepinone (CHEBI:31413)

Targets

Kind
Protein group
Organism
Human
Pharmacological action
Yes
Actions
Positive allosteric modulator
General Function
Inhibitory extracellular ligand-gated ion channel activity
Specific Function
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine...

Components:
References
  1. Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. [PubMed:11752090]
  2. Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. doi: 10.1111/j.1600-0404.2008.01004.x. Epub 2008 Mar 31. [PubMed:18384456]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
Inducer
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Steroid hydroxylase activity
Specific Function
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and im...
Gene Name
CYP2C19
Uniprot ID
P33261
Uniprot Name
Cytochrome P450 2C19
Molecular Weight
55930.545 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2B6
Uniprot ID
P20813
Uniprot Name
Cytochrome P450 2B6
Molecular Weight
56277.81 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2C18
Uniprot ID
P33260
Uniprot Name
Cytochrome P450 2C18
Molecular Weight
55710.075 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Steroid hydroxylase activity
Specific Function
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic...
Gene Name
CYP2D6
Uniprot ID
P10635
Uniprot Name
Cytochrome P450 2D6
Molecular Weight
55768.94 Da

Transporters

Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Other
General Function
Neurotransmitter:sodium symporter activity
Specific Function
Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.
Gene Name
SLC6A1
Uniprot ID
P30531
Uniprot Name
Sodium- and chloride-dependent GABA transporter 1
Molecular Weight
67073.0 Da
References
  1. Giarratano M, Standley K, Benbadis SR: Clobazam for treatment of epilepsy. Expert Opin Pharmacother. 2012 Feb;13(2):227-33. doi: 10.1517/14656566.2012.647686. Epub 2012 Jan 13. [PubMed:22242724]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Other
General Function
Neurotransmitter:sodium symporter activity
Specific Function
Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.
Gene Name
SLC6A11
Uniprot ID
P48066
Uniprot Name
Sodium- and chloride-dependent GABA transporter 3
Molecular Weight
70605.145 Da
References
  1. Giarratano M, Standley K, Benbadis SR: Clobazam for treatment of epilepsy. Expert Opin Pharmacother. 2012 Feb;13(2):227-33. doi: 10.1517/14656566.2012.647686. Epub 2012 Jan 13. [PubMed:22242724]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Xenobiotic-transporting atpase activity
Specific Function
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name
ABCB1
Uniprot ID
P08183
Uniprot Name
Multidrug resistance protein 1
Molecular Weight
141477.255 Da

Drug created on June 13, 2005 07:24 / Updated on August 15, 2018 09:39