Identification

Name
Adipiplon
Accession Number
DB06579
Type
Small Molecule
Groups
Investigational
Description

Adipiplon (NG2-73) is an anxiolytic drug developed by Neurogen Corporation. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic.

Structure
Thumb
Synonyms
Not Available
External IDs
NG2-73
Categories
UNII
OPL214POJ1
CAS number
840486-93-3
Weight
Average: 351.389
Monoisotopic: 351.160771771
Chemical Formula
C18H18FN7
InChI Key
UAMAIHOEGLEXSV-UHFFFAOYSA-N
InChI
InChI=1S/C18H18FN7/c1-3-5-13-15(22-11-26-17(13)23-12(2)24-26)10-25-9-8-21-18(25)16-14(19)6-4-7-20-16/h4,6-9,11H,3,5,10H2,1-2H3
IUPAC Name
3-fluoro-2-[1-({2-methyl-8-propyl-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl}methyl)-1H-imidazol-2-yl]pyridine
SMILES
CCCC1=C(CN2C=CN=C2C2=C(F)C=CC=N2)N=CN2N=C(C)N=C12

Pharmacology

Indication

Investigated for use/treatment in insomnia and sleep disorders.

Structured Indications
Not Available
Pharmacodynamics
Not Available
Mechanism of action
TargetActionsOrganism
AGABA-A receptor (benzodiazepine site)
partial agonist
Human
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
7-NitroindazoleThe risk or severity of adverse effects can be increased when 7-Nitroindazole is combined with Adipiplon.Experimental
AcepromazineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Adipiplon.Approved, Vet Approved
AceprometazineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Adipiplon.Approved
AgomelatineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Agomelatine.Approved, Investigational
AlaproclateThe risk or severity of adverse effects can be increased when Adipiplon is combined with Alaproclate.Experimental
AlfaxaloneThe risk or severity of adverse effects can be increased when Adipiplon is combined with Alfaxalone.Vet Approved
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Adipiplon.Approved, Illicit
AllopregnanoloneThe risk or severity of adverse effects can be increased when Adipiplon is combined with Allopregnanolone.Investigational
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Alphacetylmethadol is combined with Adipiplon.Experimental, Illicit
AlphaprodineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Alphaprodine.Illicit
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Adipiplon.Approved, Illicit, Investigational
AmisulprideThe risk or severity of adverse effects can be increased when Amisulpride is combined with Adipiplon.Approved, Investigational
AmitriptylineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Amitriptyline.Approved
AmobarbitalThe risk or severity of adverse effects can be increased when Amobarbital is combined with Adipiplon.Approved, Illicit
AmoxapineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Amoxapine.Approved
AmperozideThe risk or severity of adverse effects can be increased when Adipiplon is combined with Amperozide.Experimental
AripiprazoleThe risk or severity of adverse effects can be increased when Aripiprazole is combined with Adipiplon.Approved, Investigational
ArticaineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Articaine.Approved
AsenapineThe risk or severity of adverse effects can be increased when Asenapine is combined with Adipiplon.Approved
AzaperoneThe risk or severity of adverse effects can be increased when Adipiplon is combined with Azaperone.Investigational, Vet Approved
AzelastineAdipiplon may increase the central nervous system depressant (CNS depressant) activities of Azelastine.Approved
BaclofenThe risk or severity of adverse effects can be increased when Adipiplon is combined with Baclofen.Approved
BarbitalThe risk or severity of adverse effects can be increased when Barbital is combined with Adipiplon.Illicit
BenperidolThe risk or severity of adverse effects can be increased when Adipiplon is combined with Benperidol.Investigational
BenzocaineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Adipiplon.Approved
Benzyl alcoholThe risk or severity of adverse effects can be increased when Adipiplon is combined with Benzyl alcohol.Approved
BrexpiprazoleThe risk or severity of adverse effects can be increased when Adipiplon is combined with Brexpiprazole.Approved
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Adipiplon.Approved
BromazepamThe risk or severity of adverse effects can be increased when Bromazepam is combined with Adipiplon.Approved, Illicit
BromisovalThe risk or severity of adverse effects can be increased when Adipiplon is combined with Bromisoval.Experimental
BromperidolThe risk or severity of adverse effects can be increased when Adipiplon is combined with Bromperidol.Investigational
BrompheniramineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Brompheniramine.Approved
BrotizolamThe risk or severity of adverse effects can be increased when Adipiplon is combined with Brotizolam.Approved, Investigational, Withdrawn
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Adipiplon.Approved, Investigational
BuprenorphineAdipiplon may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Adipiplon.Approved, Investigational
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Adipiplon.Approved, Illicit
ButacaineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Butacaine.Vet Approved
ButalbitalThe risk or severity of adverse effects can be increased when Adipiplon is combined with Butalbital.Approved, Illicit
ButambenThe risk or severity of adverse effects can be increased when Adipiplon is combined with Butamben.Approved
ButethalThe risk or severity of adverse effects can be increased when Butethal is combined with Adipiplon.Approved, Illicit
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Adipiplon.Approved, Illicit, Vet Approved
CanertinibThe risk or severity of adverse effects can be increased when Canertinib is combined with Adipiplon.Investigational
CarbamazepineThe risk or severity of adverse effects can be increased when Carbamazepine is combined with Adipiplon.Approved, Investigational
CarbinoxamineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Carbinoxamine.Approved
CarfentanilThe risk or severity of adverse effects can be increased when Carfentanil is combined with Adipiplon.Illicit, Investigational, Vet Approved
CarisoprodolThe risk or severity of adverse effects can be increased when Adipiplon is combined with Carisoprodol.Approved
CetirizineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Cetirizine.Approved
Chloral hydrateThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Adipiplon.Approved, Illicit, Vet Approved
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Adipiplon.Approved, Illicit
ChlormezanoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Adipiplon.Approved, Investigational, Withdrawn
ChloroprocaineThe risk or severity of adverse effects can be increased when Chloroprocaine is combined with Adipiplon.Approved
ChlorphenamineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Chlorphenamine.Approved
ChlorpromazineThe risk or severity of adverse effects can be increased when Chlorpromazine is combined with Adipiplon.Approved, Vet Approved
ChlorprothixeneThe risk or severity of adverse effects can be increased when Chlorprothixene is combined with Adipiplon.Approved, Investigational, Withdrawn
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Adipiplon is combined with Chlorzoxazone.Approved
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Adipiplon.Approved, Vet Approved
CitalopramThe risk or severity of adverse effects can be increased when Adipiplon is combined with Citalopram.Approved
ClemastineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Clemastine.Approved
ClidiniumThe risk or severity of adverse effects can be increased when Adipiplon is combined with Clidinium.Approved
ClobazamThe risk or severity of adverse effects can be increased when Adipiplon is combined with Clobazam.Approved, Illicit
clomethiazoleThe risk or severity of adverse effects can be increased when clomethiazole is combined with Adipiplon.Investigational
ClomipramineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Clomipramine.Approved, Vet Approved
ClonazepamThe risk or severity of adverse effects can be increased when Adipiplon is combined with Clonazepam.Approved, Illicit
ClonidineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Clonidine.Approved
ClopenthixolThe risk or severity of adverse effects can be increased when Adipiplon is combined with Clopenthixol.Experimental
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Adipiplon.Approved, Illicit
ClothiapineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Clothiapine.Experimental
ClozapineThe risk or severity of adverse effects can be increased when Clozapine is combined with Adipiplon.Approved
CocaineThe risk or severity of adverse effects can be increased when Cocaine is combined with Adipiplon.Approved, Illicit
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Adipiplon.Approved, Illicit
CyclizineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Cyclizine.Approved
CyclobenzaprineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Adipiplon.Approved
CyproheptadineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Cyproheptadine.Approved
DantroleneThe risk or severity of adverse effects can be increased when Adipiplon is combined with Dantrolene.Approved
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Adipiplon.Approved
DapoxetineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Dapoxetine.Investigational
DeramciclaneThe risk or severity of adverse effects can be increased when Deramciclane is combined with Adipiplon.Investigational
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Adipiplon.Approved
DesipramineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Desipramine.Approved
DesloratadineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Desloratadine.Approved, Investigational
DesvenlafaxineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Desvenlafaxine.Approved
DetomidineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Detomidine.Vet Approved
DexbrompheniramineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Dexbrompheniramine.Approved
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Adipiplon.Approved, Vet Approved
DextromoramideThe risk or severity of adverse effects can be increased when Dextromoramide is combined with Adipiplon.Experimental, Illicit
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Adipiplon.Approved, Illicit, Investigational, Withdrawn
DezocineThe risk or severity of adverse effects can be increased when Dezocine is combined with Adipiplon.Approved, Investigational
DiazepamThe risk or severity of adverse effects can be increased when Diazepam is combined with Adipiplon.Approved, Illicit, Vet Approved
Diethyl etherThe risk or severity of adverse effects can be increased when Adipiplon is combined with Diethyl ether.Experimental
DifenoxinThe risk or severity of adverse effects can be increased when Adipiplon is combined with Difenoxin.Approved, Illicit
DihydrocodeineThe risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Adipiplon.Approved, Illicit
DihydroetorphineThe risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Adipiplon.Experimental, Illicit
DihydromorphineThe risk or severity of adverse effects can be increased when Dihydromorphine is combined with Adipiplon.Experimental, Illicit
DimenhydrinateThe risk or severity of adverse effects can be increased when Adipiplon is combined with Dimenhydrinate.Approved
DiphenhydramineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Adipiplon.Approved
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Adipiplon.Approved, Illicit
DixyrazineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Dixyrazine.Experimental
DoramectinThe risk or severity of adverse effects can be increased when Adipiplon is combined with Doramectin.Vet Approved
DoxepinThe risk or severity of adverse effects can be increased when Adipiplon is combined with Doxepin.Approved
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Adipiplon.Approved, Vet Approved
DPDPEThe risk or severity of adverse effects can be increased when Adipiplon is combined with DPDPE.Experimental
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Adipiplon.Approved, Illicit
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Adipiplon.Approved, Vet Approved
DrotebanolThe risk or severity of adverse effects can be increased when Drotebanol is combined with Adipiplon.Experimental, Illicit
DuloxetineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Duloxetine.Approved
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Adipiplon.Approved
EcgonineThe risk or severity of adverse effects can be increased when Ecgonine is combined with Adipiplon.Experimental, Illicit
EcopipamThe risk or severity of adverse effects can be increased when Adipiplon is combined with Ecopipam.Investigational
EfavirenzThe risk or severity of adverse effects can be increased when Adipiplon is combined with Efavirenz.Approved, Investigational
EltanoloneThe risk or severity of adverse effects can be increased when Adipiplon is combined with Eltanolone.Investigational
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Adipiplon.Approved, Investigational, Vet Approved
EntacaponeThe risk or severity of adverse effects can be increased when Adipiplon is combined with Entacapone.Approved, Investigational
EscitalopramThe risk or severity of adverse effects can be increased when Adipiplon is combined with Escitalopram.Approved, Investigational
EstazolamThe risk or severity of adverse effects can be increased when Estazolam is combined with Adipiplon.Approved, Illicit
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Adipiplon.Approved
EthanolAdipiplon may increase the central nervous system depressant (CNS depressant) activities of Ethanol.Approved
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Adipiplon.Approved, Illicit, Withdrawn
EthosuximideThe risk or severity of adverse effects can be increased when Adipiplon is combined with Ethosuximide.Approved
EthotoinThe risk or severity of adverse effects can be increased when Adipiplon is combined with Ethotoin.Approved
Ethyl carbamateThe risk or severity of adverse effects can be increased when Ethyl carbamate is combined with Adipiplon.Withdrawn
Ethyl chlorideThe risk or severity of adverse effects can be increased when Adipiplon is combined with Ethyl chloride.Experimental, Investigational
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Ethyl loflazepate is combined with Adipiplon.Approved, Illicit
EthylmorphineThe risk or severity of adverse effects can be increased when Ethylmorphine is combined with Adipiplon.Approved, Illicit
EtidocaineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Etidocaine.Approved
EtifoxineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Etifoxine.Investigational, Withdrawn
EtizolamThe risk or severity of adverse effects can be increased when Adipiplon is combined with Etizolam.Approved
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Adipiplon.Approved
EtoperidoneThe risk or severity of adverse effects can be increased when Adipiplon is combined with Etoperidone.Withdrawn
EtorphineThe risk or severity of adverse effects can be increased when Etorphine is combined with Adipiplon.Illicit, Vet Approved
EzogabineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Ezogabine.Approved
FelbamateThe risk or severity of adverse effects can be increased when Adipiplon is combined with Felbamate.Approved
FencamfamineThe risk or severity of adverse effects can be increased when Fencamfamine is combined with Adipiplon.Approved, Illicit, Withdrawn
FentanylThe risk or severity of adverse effects can be increased when Fentanyl is combined with Adipiplon.Approved, Illicit, Investigational, Vet Approved
FexofenadineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Fexofenadine.Approved
FlibanserinThe risk or severity of adverse effects can be increased when Adipiplon is combined with Flibanserin.Approved
FluanisoneThe risk or severity of adverse effects can be increased when Adipiplon is combined with Fluanisone.Experimental
FludiazepamThe risk or severity of adverse effects can be increased when Fludiazepam is combined with Adipiplon.Approved, Illicit
FlunarizineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Flunarizine.Approved
FlunitrazepamThe risk or severity of adverse effects can be increased when Flunitrazepam is combined with Adipiplon.Approved, Illicit
FluoxetineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Fluoxetine.Approved, Vet Approved
FlupentixolThe risk or severity of adverse effects can be increased when Flupentixol is combined with Adipiplon.Approved, Withdrawn
FluphenazineThe risk or severity of adverse effects can be increased when Fluphenazine is combined with Adipiplon.Approved
FlurazepamThe risk or severity of adverse effects can be increased when Flurazepam is combined with Adipiplon.Approved, Illicit
FluspirileneThe risk or severity of adverse effects can be increased when Fluspirilene is combined with Adipiplon.Approved, Investigational
Fluticasone propionateThe risk or severity of adverse effects can be increased when Adipiplon is combined with Fluticasone propionate.Approved
FluvoxamineThe risk or severity of adverse effects can be increased when Fluvoxamine is combined with Adipiplon.Approved, Investigational
FosphenytoinThe risk or severity of adverse effects can be increased when Adipiplon is combined with Fosphenytoin.Approved
FospropofolThe risk or severity of adverse effects can be increased when Adipiplon is combined with Fospropofol.Approved, Illicit, Investigational
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Adipiplon.Approved, Investigational
Gabapentin EnacarbilThe risk or severity of adverse effects can be increased when Adipiplon is combined with Gabapentin Enacarbil.Approved
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Adipiplon.Approved, Illicit, Investigational
GepironeThe risk or severity of adverse effects can be increased when Adipiplon is combined with Gepirone.Investigational
GlutethimideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Adipiplon.Approved, Illicit
GuanfacineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Guanfacine.Approved, Investigational
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with Adipiplon.Approved, Illicit, Withdrawn
HaloperidolThe risk or severity of adverse effects can be increased when Haloperidol is combined with Adipiplon.Approved
HalothaneThe risk or severity of adverse effects can be increased when Halothane is combined with Adipiplon.Approved, Vet Approved
HeroinThe risk or severity of adverse effects can be increased when Heroin is combined with Adipiplon.Approved, Illicit, Investigational
HexobarbitalThe risk or severity of adverse effects can be increased when Hexobarbital is combined with Adipiplon.Approved
HydrocodoneAdipiplon may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.Approved, Illicit
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Adipiplon.Approved, Illicit
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Adipiplon.Approved
IloperidoneThe risk or severity of adverse effects can be increased when Adipiplon is combined with Iloperidone.Approved
ImipramineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Imipramine.Approved
IndalpineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Indalpine.Investigational, Withdrawn
IndiplonThe risk or severity of adverse effects can be increased when Adipiplon is combined with Indiplon.Investigational
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Adipiplon.Approved, Vet Approved
KetamineThe risk or severity of adverse effects can be increased when Ketamine is combined with Adipiplon.Approved, Vet Approved
KetazolamThe risk or severity of adverse effects can be increased when Ketazolam is combined with Adipiplon.Approved
KetobemidoneThe risk or severity of adverse effects can be increased when Adipiplon is combined with Ketobemidone.Approved, Investigational
LamotrigineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Lamotrigine.Approved, Investigational
LevetiracetamThe risk or severity of adverse effects can be increased when Adipiplon is combined with Levetiracetam.Approved, Investigational
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Adipiplon.Approved, Investigational
LevocabastineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Levocabastine.Approved
LevocetirizineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Levocetirizine.Approved
LevodopaThe risk or severity of adverse effects can be increased when Adipiplon is combined with Levodopa.Approved
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Adipiplon.Approved, Investigational
LevomilnacipranThe risk or severity of adverse effects can be increased when Adipiplon is combined with Levomilnacipran.Approved
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Adipiplon.Approved
LidocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Adipiplon.Approved, Vet Approved
LithiumThe risk or severity of adverse effects can be increased when Lithium is combined with Adipiplon.Approved
LofentanilThe risk or severity of adverse effects can be increased when Adipiplon is combined with Lofentanil.Illicit
LoprazolamThe risk or severity of adverse effects can be increased when Adipiplon is combined with Loprazolam.Experimental
LoratadineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Loratadine.Approved
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Adipiplon.Approved
LormetazepamThe risk or severity of adverse effects can be increased when Adipiplon is combined with Lormetazepam.Approved
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Adipiplon.Approved
LurasidoneThe risk or severity of adverse effects can be increased when Lurasidone is combined with Adipiplon.Approved
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Adipiplon.Approved, Vet Approved
MaprotilineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Maprotiline.Approved
MebicarThe risk or severity of adverse effects can be increased when Adipiplon is combined with Mebicar.Experimental
MeclizineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Meclizine.Approved
MedazepamThe risk or severity of adverse effects can be increased when Adipiplon is combined with Medazepam.Experimental
MedetomidineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Medetomidine.Vet Approved
MelatoninThe risk or severity of adverse effects can be increased when Melatonin is combined with Adipiplon.Approved, Nutraceutical, Vet Approved
MelperoneThe risk or severity of adverse effects can be increased when Adipiplon is combined with Melperone.Approved, Investigational
MepivacaineThe risk or severity of adverse effects can be increased when Mepivacaine is combined with Adipiplon.Approved, Vet Approved
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Adipiplon.Approved, Illicit
MeptazinolThe risk or severity of adverse effects can be increased when Adipiplon is combined with Meptazinol.Experimental
MesoridazineThe risk or severity of adverse effects can be increased when Mesoridazine is combined with Adipiplon.Approved, Investigational
MetaxaloneThe risk or severity of adverse effects can be increased when Adipiplon is combined with Metaxalone.Approved
MethadoneThe risk or severity of adverse effects can be increased when Methadone is combined with Adipiplon.Approved
Methadyl AcetateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Adipiplon.Approved, Illicit
MethapyrileneThe risk or severity of adverse effects can be increased when Methapyrilene is combined with Adipiplon.Withdrawn
MethaqualoneThe risk or severity of adverse effects can be increased when Methaqualone is combined with Adipiplon.Illicit, Withdrawn
MethocarbamolThe risk or severity of adverse effects can be increased when Adipiplon is combined with Methocarbamol.Approved, Vet Approved
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Adipiplon.Approved
MethotrimeprazineAdipiplon may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.Approved
MethoxyfluraneThe risk or severity of adverse effects can be increased when Methoxyflurane is combined with Adipiplon.Approved, Investigational, Vet Approved
MethsuximideThe risk or severity of adverse effects can be increased when Adipiplon is combined with Methsuximide.Approved
MethylecgonineThe risk or severity of adverse effects can be increased when Methylecgonine is combined with Adipiplon.Experimental
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Adipiplon.Approved
MetyrosineAdipiplon may increase the sedative activities of Metyrosine.Approved
MidazolamThe risk or severity of adverse effects can be increased when Midazolam is combined with Adipiplon.Approved, Illicit
MilnacipranThe risk or severity of adverse effects can be increased when Adipiplon is combined with Milnacipran.Approved
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Adipiplon.Approved, Investigational
MirtazapineAdipiplon may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.Approved
MolindoneThe risk or severity of adverse effects can be increased when Molindone is combined with Adipiplon.Approved
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Adipiplon.Approved, Investigational
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Adipiplon.Approved, Investigational
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Adipiplon.Approved
NefazodoneThe risk or severity of adverse effects can be increased when Adipiplon is combined with Nefazodone.Approved, Withdrawn
NitrazepamThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Adipiplon.Approved
Nitrous oxideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Adipiplon.Approved, Vet Approved
NorfluraneThe risk or severity of adverse effects can be increased when Adipiplon is combined with Norflurane.Investigational
NormethadoneThe risk or severity of adverse effects can be increased when Adipiplon is combined with Normethadone.Approved, Illicit
NortriptylineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Nortriptyline.Approved
OlanzapineThe risk or severity of adverse effects can be increased when Olanzapine is combined with Adipiplon.Approved, Investigational
OlopatadineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Olopatadine.Approved
OndansetronThe risk or severity of adverse effects can be increased when Ondansetron is combined with Adipiplon.Approved
OpiumThe risk or severity of adverse effects can be increased when Adipiplon is combined with Opium.Approved, Illicit
OrphenadrineAdipiplon may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.Approved
OsanetantThe risk or severity of adverse effects can be increased when Osanetant is combined with Adipiplon.Investigational
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with Adipiplon.Approved
OxethazaineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Oxethazaine.Approved, Investigational
OxprenololThe risk or severity of adverse effects can be increased when Oxprenolol is combined with Adipiplon.Approved
OxybuprocaineThe risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Adipiplon.Approved
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Adipiplon.Approved, Illicit, Investigational
OxymorphoneThe risk or severity of adverse effects can be increased when Oxymorphone is combined with Adipiplon.Approved, Investigational, Vet Approved
PaliperidoneThe risk or severity of adverse effects can be increased when Paliperidone is combined with Adipiplon.Approved
ParaldehydeAdipiplon may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
ParoxetineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Paroxetine.Approved, Investigational
PenfluridolThe risk or severity of adverse effects can be increased when Adipiplon is combined with Penfluridol.Experimental
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Adipiplon.Approved, Vet Approved
PentobarbitalThe risk or severity of adverse effects can be increased when Pentobarbital is combined with Adipiplon.Approved, Vet Approved
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Adipiplon.Approved
PerazineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Perazine.Investigational
PerospironeThe risk or severity of adverse effects can be increased when Adipiplon is combined with Perospirone.Approved
PerphenazineThe risk or severity of adverse effects can be increased when Perphenazine is combined with Adipiplon.Approved
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Adipiplon.Approved
PhenazocineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Phenazocine.Experimental
PhenibutThe risk or severity of adverse effects can be increased when Adipiplon is combined with Phenibut.Experimental
PhenobarbitalThe risk or severity of adverse effects can be increased when Phenobarbital is combined with Adipiplon.Approved
PhenoperidineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Phenoperidine.Experimental
PhenoxyethanolThe risk or severity of adverse effects can be increased when Adipiplon is combined with Phenoxyethanol.Approved
PhenytoinThe risk or severity of adverse effects can be increased when Adipiplon is combined with Phenytoin.Approved, Vet Approved
PimozideThe risk or severity of adverse effects can be increased when Pimozide is combined with Adipiplon.Approved
PipamperoneThe risk or severity of adverse effects can be increased when Adipiplon is combined with Pipamperone.Approved, Investigational
PipotiazineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Pipotiazine.Approved, Investigational
PiritramideThe risk or severity of adverse effects can be increased when Adipiplon is combined with Piritramide.Investigational
PizotifenThe risk or severity of adverse effects can be increased when Adipiplon is combined with Pizotifen.Approved
PomalidomideThe risk or severity of adverse effects can be increased when Adipiplon is combined with Pomalidomide.Approved
PramipexoleAdipiplon may increase the sedative activities of Pramipexole.Approved, Investigational
PramocaineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Pramocaine.Approved
PrazepamThe risk or severity of adverse effects can be increased when Prazepam is combined with Adipiplon.Approved, Illicit
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Adipiplon.Approved, Illicit, Investigational
PrilocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Adipiplon.Approved
PrimidoneThe risk or severity of adverse effects can be increased when Adipiplon is combined with Primidone.Approved, Vet Approved
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with Adipiplon.Approved, Investigational, Vet Approved
ProchlorperazineThe risk or severity of adverse effects can be increased when Prochlorperazine is combined with Adipiplon.Approved, Vet Approved
PromazineThe risk or severity of adverse effects can be increased when Promazine is combined with Adipiplon.Approved, Vet Approved
PromethazineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Promethazine.Approved
PropanididThe risk or severity of adverse effects can be increased when Adipiplon is combined with Propanidid.Experimental
ProparacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Adipiplon.Approved, Vet Approved
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Adipiplon.Approved, Investigational, Vet Approved
PropoxycaineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Propoxycaine.Approved
ProtriptylineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Protriptyline.Approved
ProxibarbalThe risk or severity of adverse effects can be increased when Adipiplon is combined with Proxibarbal.Experimental
PSD502The risk or severity of adverse effects can be increased when Adipiplon is combined with PSD502.Investigational
QuazepamThe risk or severity of adverse effects can be increased when Quazepam is combined with Adipiplon.Approved, Illicit
QuetiapineThe risk or severity of adverse effects can be increased when Quetiapine is combined with Adipiplon.Approved
QuinisocaineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Quinisocaine.Experimental
RacloprideThe risk or severity of adverse effects can be increased when Adipiplon is combined with Raclopride.Investigational
RamelteonThe risk or severity of adverse effects can be increased when Adipiplon is combined with Ramelteon.Approved, Investigational
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Adipiplon.Approved
RemoxiprideThe risk or severity of adverse effects can be increased when Remoxipride is combined with Adipiplon.Approved, Withdrawn
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Adipiplon.Approved, Investigational
RisperidoneThe risk or severity of adverse effects can be increased when Risperidone is combined with Adipiplon.Approved, Investigational
RitanserinThe risk or severity of adverse effects can be increased when Adipiplon is combined with Ritanserin.Investigational
RomifidineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Romifidine.Vet Approved
RopiniroleAdipiplon may increase the sedative activities of Ropinirole.Approved, Investigational
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Adipiplon.Approved
RotigotineAdipiplon may increase the sedative activities of Rotigotine.Approved
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Adipiplon.Approved
ScopolamineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Scopolamine.Approved
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Adipiplon.Approved, Vet Approved
SepranoloneThe risk or severity of adverse effects can be increased when Adipiplon is combined with Sepranolone.Investigational
SertindoleThe risk or severity of adverse effects can be increased when Sertindole is combined with Adipiplon.Approved, Investigational, Withdrawn
SertralineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Sertraline.Approved
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Adipiplon.Approved, Vet Approved
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Adipiplon.Approved
StiripentolThe risk or severity of adverse effects can be increased when Adipiplon is combined with Stiripentol.Approved
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Adipiplon.Approved, Investigational
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Adipiplon.Approved, Investigational
SultoprideThe risk or severity of adverse effects can be increased when Adipiplon is combined with Sultopride.Experimental
SuvorexantAdipiplon may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.Approved
TandospironeThe risk or severity of adverse effects can be increased when Adipiplon is combined with Tandospirone.Investigational
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Adipiplon.Approved
TasimelteonThe risk or severity of adverse effects can be increased when Adipiplon is combined with Tasimelteon.Approved
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Adipiplon.Approved
TetrabenazineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Tetrabenazine.Approved
TetracaineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Tetracaine.Approved, Vet Approved
TetrahydropalmatineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Tetrahydropalmatine.Investigational
TetrodotoxinThe risk or severity of adverse effects can be increased when Tetrodotoxin is combined with Adipiplon.Investigational
ThalidomideAdipiplon may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.Approved, Investigational, Withdrawn
ThiamylalThe risk or severity of adverse effects can be increased when Thiamylal is combined with Adipiplon.Approved, Vet Approved
ThiopentalThe risk or severity of adverse effects can be increased when Thiopental is combined with Adipiplon.Approved, Vet Approved
ThioridazineThe risk or severity of adverse effects can be increased when Thioridazine is combined with Adipiplon.Approved, Withdrawn
ThiothixeneThe risk or severity of adverse effects can be increased when Thiothixene is combined with Adipiplon.Approved
TiagabineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Tiagabine.Approved
TiaprideThe risk or severity of adverse effects can be increased when Adipiplon is combined with Tiapride.Approved, Investigational
TiletamineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Tiletamine.Vet Approved
TilidineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Tilidine.Experimental
TizanidineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Tizanidine.Approved
TolcaponeThe risk or severity of adverse effects can be increased when Adipiplon is combined with Tolcapone.Approved, Withdrawn
TopiramateThe risk or severity of adverse effects can be increased when Adipiplon is combined with Topiramate.Approved
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Adipiplon.Approved, Investigational
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Trans-2-Phenylcyclopropylamine is combined with Adipiplon.Experimental
TranylcypromineThe risk or severity of adverse effects can be increased when Tranylcypromine is combined with Adipiplon.Approved
TrazodoneThe risk or severity of adverse effects can be increased when Trazodone is combined with Adipiplon.Approved, Investigational
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with Adipiplon.Approved
Tricaine methanesulfonateThe risk or severity of adverse effects can be increased when Adipiplon is combined with Tricaine methanesulfonate.Vet Approved
TrichloroethyleneThe risk or severity of adverse effects can be increased when Adipiplon is combined with Trichloroethylene.Approved
TrifluoperazineThe risk or severity of adverse effects can be increased when Trifluoperazine is combined with Adipiplon.Approved
TrifluperidolThe risk or severity of adverse effects can be increased when Adipiplon is combined with Trifluperidol.Experimental
TriflupromazineThe risk or severity of adverse effects can be increased when Triflupromazine is combined with Adipiplon.Approved, Vet Approved
TrimipramineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Trimipramine.Approved
TriprolidineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Triprolidine.Approved
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Adipiplon.Approved, Investigational
VenlafaxineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Venlafaxine.Approved
VeraliprideThe risk or severity of adverse effects can be increased when Adipiplon is combined with Veralipride.Experimental
VigabatrinThe risk or severity of adverse effects can be increased when Adipiplon is combined with Vigabatrin.Approved
Vinyl etherThe risk or severity of adverse effects can be increased when Adipiplon is combined with Vinyl ether.Experimental
VortioxetineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Vortioxetine.Approved
XenonThe risk or severity of adverse effects can be increased when Adipiplon is combined with Xenon.Experimental
XylazineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Xylazine.Vet Approved
YohimbineThe therapeutic efficacy of Adipiplon can be decreased when used in combination with Yohimbine.Approved, Vet Approved
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with Adipiplon.Approved, Illicit, Investigational
ZiconotideThe risk or severity of adverse effects can be increased when Adipiplon is combined with Ziconotide.Approved
ZimelidineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Zimelidine.Withdrawn
ZiprasidoneThe risk or severity of adverse effects can be increased when Ziprasidone is combined with Adipiplon.Approved
ZolazepamThe risk or severity of adverse effects can be increased when Adipiplon is combined with Zolazepam.Vet Approved
ZolpidemAdipiplon may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.Approved
ZonisamideThe risk or severity of adverse effects can be increased when Adipiplon is combined with Zonisamide.Approved, Investigational
ZopicloneThe risk or severity of adverse effects can be increased when Zopiclone is combined with Adipiplon.Approved
ZotepineThe risk or severity of adverse effects can be increased when Adipiplon is combined with Zotepine.Approved, Investigational
ZuclopenthixolThe risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Adipiplon.Approved, Investigational
Food Interactions
Not Available

References

General References
Not Available
External Links
PubChem Compound
11198924
PubChem Substance
347827777
ChemSpider
9373993
ChEMBL
CHEMBL2103791
Wikipedia
Adipiplon

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2TerminatedTreatmentPrimary Insomnia1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.031 mg/mLALOGPS
logP2.53ALOGPS
logP3.24ChemAxon
logS-4ALOGPS
pKa (Strongest Basic)2.96ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area73.79 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity116.55 m3·mol-1ChemAxon
Polarizability35.5 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as triazolopyrimidines. These are polycyclic aromatic compounds containing triazole ring fused to a pyrimidine ring. Triazole is a five-membered ring consisting of two carbon atoms and three nitrogen atoms. Pyrimidine is a 6-membered ring consisting of four carbon atoms and two nitrogen centers at the 1- and 3- ring positions.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Triazolopyrimidines
Sub Class
Not Available
Direct Parent
Triazolopyrimidines
Alternative Parents
Pyrimidines and pyrimidine derivatives / Pyridines and derivatives / N-substituted imidazoles / Aryl fluorides / Triazoles / Heteroaromatic compounds / Azacyclic compounds / Organonitrogen compounds / Organofluorides / Hydrocarbon derivatives
Substituents
Triazolopyrimidine / Aryl fluoride / Aryl halide / N-substituted imidazole / Pyridine / Pyrimidine / Triazole / Imidazole / Azole / 1,2,4-triazole
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
Not Available

Targets

Kind
Protein group
Organism
Human
Pharmacological action
Yes
Actions
Partial agonist
General Function
Inhibitory extracellular ligand-gated ion channel activity
Specific Function
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine...

Components:
References
  1. Development of Subtype-Selective GABAA Receptor Compounds for the Treatment of Anxiety, Sleep Disorders and Epilepsy [Link]

Drug created on March 19, 2008 10:37 / Updated on December 01, 2017 15:39