Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE).
DrugDrug NameDrug Indication
DB12082VesnarinoneNot Available
DB12286SimendanNot Available
DB12779HigenamineNot Available
DB13191PhosphocreatineNot Available
DB13307ProscillaridinNot Available
DB00235MilrinoneIndicated for the treatment of congestive heart failure.
DB00380DexrazoxaneFor reducing the incidence and severity of cardiomyopathy associated with doxorubicin administration in women with metastatic breast cancer who have received a cumulative doxorubicin hydrochloride dose of 300 mg/m^2 and would benefit from continued doxorubicin therapy. Also approved for the treatment of extravasation from intravenous anthracyclines.
DB00388PhenylephrinePhenylephrine is mainly used to treat nasal congestion, but may also be useful in treating hypotension and shock, hypotension during spinal anaesthesia, prolongation of spinal anaesthesia, paroxysmal supraventricular tachycardia, symptomatic relief of external or internal hemorrhoids, and to increase blood pressure as an aid in the diagnosis of heart murmurs.
DB00390DigoxinFor the treatment and management of congestive cardiac insufficiency, arrhythmias and heart failure.
DB00411CarbacholPrimarily used in the treatment of glaucoma, but is also used during ophthalmic surgery.
DB00511AcetyldigitoxinUsed for fast digitalization in congestive heart failure.
DB00722LisinoprilFor the treatment of hypertension and symptomatic congestive heart failure. May be used in conjunction with thrombolytic agents, aspirin and/or β-blockers to improve survival in hemodynamically stable individuals following myocardial infarction. May be used to slow the progression of renal disease in hypertensive patients with diabetes mellitus and microalbuminuria or overt nephropathy.
DB00841DobutamineFor inotropic support in the short- term treatment of patients with cardiac decompensation due to depressed contractility resulting either from organic heart disease or from cardiac surgical procedures
DB00922LevosimendanFor short term treatment of acutely decompensated severe chronic heart failure (CHF). Also being investigated for use/treatment in heart disease.
DB00988DopamineFor the correction of hemodynamic imbalances present in the shock syndrome due to myocardial infarction, trauma, endotoxic septicemia, open-heart surgery, renal failure, and chronic cardiac decompensation as in congestive failure
DB01064IsoprenalineFor the treatment of mild or transient episodes of heart block that do not require electric shock or pacemaker therapy also used in management of asthma and chronic bronchitis
DB01078DeslanosideFor the treatment and management of Congestive cardiac insufficiency, arrhythmias and heart failure.
DB01092OuabainFor the treatment of atrial fibrillation and flutter and heart failure
DB01102ArbutamineUsed to elicit acute cardiovascular responses (cardiac stumulant), similar to those produced by exercise, in order to aid in diagnosing the presence or absence of coronary artery disease (CAD) in patients who cannot exercise adequately.
DB01223AminophyllineFor the treatment of bronchospasm due to asthma, emphysema and chronic bronchitis.
DB01291PirbuterolFor the prevention and reversal of bronchospasm in patients 12 years of age and older with reversible bronchospasm including asthma.
DB01396DigitoxinFor the treatment and management of congestive cardiac insufficiency, arrhythmias and heart failure.
DB01427AmrinoneUsed in the treatment of congestive heart failure.
DB02587ColforsinNot Available
DB04880EnoximoneFor the treatment of congestive heart failure.
DB05424CanertinibInvestigated for use/treatment in breast cancer and lung cancer.
DB08985EtilefrineNot Available
DrugDrug NameTargetType
DB00235MilrinonecGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
DB00380DexrazoxaneDNA topoisomerase 2-alphatarget
DB00380DexrazoxaneDNA topoisomerase 2-betatarget
DB00388PhenylephrineAlpha-1A adrenergic receptortarget
DB00388PhenylephrineAlpha-1B adrenergic receptortarget
DB00388PhenylephrineAmine oxidase [flavin-containing] Aenzyme
DB00388PhenylephrineAlpha-1D adrenergic receptortarget
DB00388PhenylephrineCytochrome P450 1A2enzyme
DB00390DigoxinSodium/potassium-transporting ATPase subunit alpha-1target
DB00390DigoxinCholesterol side-chain cleavage enzyme, mitochondrialenzyme
DB00390DigoxinMultidrug resistance protein 1transporter
DB00390DigoxinSolute carrier organic anion transporter family member 4C1transporter
DB00390DigoxinSolute carrier family 22 member 8transporter
DB00390DigoxinSolute carrier organic anion transporter family member 2B1transporter
DB00390DigoxinBile salt export pumptransporter
DB00390DigoxinSolute carrier organic anion transporter family member 1A2transporter
DB00390DigoxinOrganic solute transporter subunit alphatransporter
DB00390DigoxinOrganic solute transporter subunit betatransporter
DB00390DigoxinSolute carrier organic anion transporter family member 4A1transporter
DB00390DigoxinSolute carrier organic anion transporter family member 1B3transporter
DB00390DigoxinSolute carrier organic anion transporter family member 1C1transporter
DB00390DigoxinSolute carrier organic anion transporter family member 1B1transporter
DB00390DigoxinCytochrome P450 3A4enzyme
DB00411CarbacholMuscarinic acetylcholine receptor M1target
DB00411CarbacholMuscarinic acetylcholine receptor M2target
DB00411CarbacholNeuronal acetylcholine receptor subunit alpha-2target
DB00411CarbacholCytosolic phospholipase A2enzyme
DB00411CarbacholAcetylcholinesterasetarget
DB00411CarbacholMuscarinic acetylcholine receptor M3target
DB00411CarbacholMuscarinic acetylcholine receptor M4target
DB00511AcetyldigitoxinSodium/potassium-transporting ATPase subunit alpha-1target
DB00722LisinoprilAngiotensin-converting enzymetarget
DB00841DobutamineBeta-1 adrenergic receptortarget
DB00841DobutamineCatechol O-methyltransferaseenzyme
DB00841DobutamineBeta-2 adrenergic receptortarget
DB00841DobutamineAlpha-2 adrenergic receptorstarget
DB00841DobutamineEstrogen receptor alphatarget
DB00922LevosimendanTroponin C, slow skeletal and cardiac musclestarget
DB00922LevosimendanATP-sensitive inward rectifier potassium channel 11target
DB00922LevosimendanATP-sensitive inward rectifier potassium channel 8target
DB00922LevosimendancGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
DB00988DopamineD(1A) dopamine receptortarget
DB00988DopamineDopamine beta-hydroxylasetarget
DB00988DopamineAmine oxidase [flavin-containing] Aenzyme
DB00988DopamineAmine oxidase [flavin-containing] Benzyme
DB00988DopamineCatechol O-methyltransferaseenzyme
DB00988DopamineSolute carrier family 22 member 2transporter
DB00988DopamineSolute carrier family 22 member 1transporter
DB00988DopamineSolute carrier family 22 member 3transporter
DB00988DopamineSolute carrier family 22 member 5transporter
DB00988DopaminePOU domain, class 5, transcription factor 1transporter
DB00988DopamineD(1B) dopamine receptortarget
DB00988DopamineD(2) dopamine receptortarget
DB00988DopamineD(3) dopamine receptortarget
DB00988DopamineD(4) dopamine receptortarget
DB00988DopamineSodium-dependent dopamine transportertarget
DB00988DopamineDopamine beta-hydroxylaseenzyme
DB00988DopamineCytochrome P450 1A2enzyme
DB00988DopamineCytochrome P450 2C19enzyme
DB00988DopamineCytochrome P450 2C9enzyme
DB00988DopamineCytochrome P450 2D6enzyme
DB00988Dopamine5-hydroxytryptamine receptor 1Atarget
DB00988Dopamine5-hydroxytryptamine receptor 7target
DB00988DopamineD(1) dopamine receptortarget
DB00988DopamineSodium-dependent noradrenaline transportertarget
DB00988DopamineSodium-dependent serotonin transportertarget
DB00988Dopamine5-hydroxytryptamine receptor 3Atarget
DB00988Dopamine5-hydroxytryptamine receptor 3Btarget
DB00988DopamineSuperoxide dismutase [Cu-Zn]target
DB00988DopamineSynaptic vesicular amine transportertarget
DB01064IsoprenalineBeta-1 adrenergic receptortarget
DB01064IsoprenalineBeta-2 adrenergic receptortarget
DB01064IsoprenalinePhosphatidylinositol 3-kinase regulatory subunit alphatarget
DB01064IsoprenalineBeta-3 adrenergic receptortarget
DB01064IsoprenalineMitogen-activated protein kinase 1target
DB01064IsoprenalinePhosphatidylinositol 3-kinase regulatory subunit betatarget
DB01064IsoprenalinePhosphatidylinositol 3-kinase regulatory subunit gammatarget
DB01064IsoprenalineCytochrome P450 1A1enzyme
DB01064IsoprenalineCAMP phosphodiesterasetarget
DB01064IsoprenalineSuperoxide dismutase [Cu-Zn]target
DB01078DeslanosideSodium/potassium-transporting ATPase subunit alpha-1target
DB01092OuabainSodium/potassium-transporting ATPase subunit alpha-1target
DB01092OuabainSolute carrier organic anion transporter family member 1A2transporter
DB01092OuabainSolute carrier family 22 member 8transporter
DB01092OuabainSolute carrier organic anion transporter family member 4C1transporter
DB01092OuabainSolute carrier organic anion transporter family member 1B3transporter
DB01092OuabainSolute carrier organic anion transporter family member 1C1transporter
DB01092OuabainSolute carrier organic anion transporter family member 1B1transporter
DB01092OuabainCytochrome P450 1A1enzyme
DB01092OuabainSodium/potassium-transporting ATPase subunit alpha-2target
DB01092OuabainSodium/potassium-transporting ATPase subunit alpha-3target
DB01102ArbutamineBeta-1 adrenergic receptortarget
DB01102ArbutamineBeta-2 adrenergic receptortarget
DB01102ArbutamineBeta-3 adrenergic receptortarget
DB01223AminophyllinecGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
DB01223AminophyllineAdenosine receptor A3target
DB01223AminophyllineAdenosine receptor A1target
DB01223AminophyllineCytochrome P450 1A2enzyme
DB01223AminophyllineCytochrome P450 2E1enzyme
DB01223AminophyllineCytochrome P450 3A4enzyme
DB01223AminophyllineHistone deacetylase 2target
DB01291PirbuterolBeta-2 adrenergic receptortarget
DB01291PirbuterolBeta-1 adrenergic receptortarget
DB01396DigitoxinSodium/potassium-transporting ATPase subunit alpha-1target
DB01396DigitoxinSerum albumincarrier
DB01396DigitoxinCholesterol side-chain cleavage enzyme, mitochondrialenzyme
DB01396DigitoxinCytochrome P450 3A4enzyme
DB01396DigitoxinSolute carrier organic anion transporter family member 1A2transporter
DB01396DigitoxinSolute carrier organic anion transporter family member 4C1transporter
DB01396DigitoxinMultidrug resistance protein 1transporter
DB01427AmrinonecAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
DB01427AmrinoneTumor necrosis factortarget
DB01427AmrinonecGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
DB01427AmrinonecAMP-specific 3',5'-cyclic phosphodiesterase 3target
DB02587ColforsinMultidrug resistance protein 1transporter
DB02587ColforsinAdenylate cyclase type 2target
DB02587ColforsinGuanine nucleotide-binding protein G(s) subunit alpha isoforms shorttarget
DB02587ColforsinAdenylate cyclase type 5target
DB02587ColforsinCystic fibrosis transmembrane conductance regulatortarget
DB04880EnoximonecGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
DB05424CanertinibEpidermal growth factor receptortarget