Cardiotonic Agents

Name
Cardiotonic Agents
Accession Number
DBCAT000589
Description

Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE).

Drugs
DrugDrug Description
MilrinoneAn inotropic vasodilator agent used to treat acute, decompensated heart failure.
DigoxinA cardiac glycoside used in the treatment of mild to moderate heart failure and for ventricular response rate control in chronic atrial fibrillation.
DexrazoxaneA cytoprotective drug used to prevent and improve cardiomyopathy associated with doxorubicin treatment for metastatic breast cancer.
PhenylephrineAn alpha-1 adrenergic agonist used in the management of hypotension, generally in the surgical setting associated with the use of anesthetics.
CarbamoylcholineA direct acting miotic agent administered ophthalmically to decrease intraocular pressure in glaucoma or after eye surgery, and to induce miosis during surgery.
AcetyldigitoxinUsed for fast digitalization in congestive heart failure.
LisinoprilAn ACE inhibitor used to treat hypertension, heart failure, and acute myocardial infarction.
DobutamineA beta-1 agonist used to treat cardiac decompensation in patients with organic heart disease or from cardiac surgery.
LevosimendanFor short term treatment of acutely decompensated severe chronic heart failure (CHF). Also being investigated for use/treatment in heart disease.
DopamineA catecholamine neurotransmitter used to treat hemodynamic imbalances, poor perfusion of vital organs, low cardiac output, and hypotension.
IsoprenalineA non-selective beta-adrenergic agonist typically used to treat bradycardia and heart block; it is structurally related to epinephrine.
DeslanosideFor the treatment and management of Congestive cardiac insufficiency, arrhythmias and heart failure.
OuabainFor the treatment of atrial fibrillation and flutter and heart failure
ArbutamineUsed to elicit acute cardiovascular responses (cardiac stumulant), similar to those produced by exercise, in order to aid in diagnosing the presence or absence of coronary artery disease (CAD) in...
AminophyllineA bronchodilator consisting of theophylline that is used for the treatment of bronchospasm due to asthma, emphysema and chronic bronchitis.
PirbuterolA beta-2 adrenergic agonist and bronchodilator used for the symptomatic treatment of asthma.
DigitoxinA cardiac glycoside used in the treatment and management of congestive cardiac insufficiency, arrhythmias and heart failure.
AmrinoneA positive inotropic agent and phosphodiesterase inhibitor used in the management of treatment of congestive heart failure.
ColforsinPotent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant Coleus forskohlii. Has antihypertensive, positive inotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities;...
EnoximoneFor the treatment of congestive heart failure.
CanertinibInvestigated for use/treatment in breast cancer and lung cancer.
TedisamilInvestigated for use/treatment in arrhythmia, atrial fibrillation, and angina.
EtilefrineEtilefrine is an adrenergic agonist that appears to interact with beta-2 and some alpha adrenergic receptors. It has been used as a vasoconstrictor agent.
PimobendanNot Annotated
VesnarinoneVesnarinone has been used in trials studying the treatment of HIV Infections and Sarcoma, Kaposi.
SimendanSimendan is under investigation in clinical trial NCT00527059 (Renal Effects of Levosimendan in Patients Admitted With Acute Decompensated Heart Failure).
HigenamineHigenamine is under investigation in clinical trial NCT01451229 (Pharmacokinetics and Pharmacodynamics of Higenamine in Chinese Healthy Subjects).
PhosphocreatinePhosphocreatine is a naturally occuring substance that is found predominantly in the skeletal muscles of vertebrates. Its primary utility within the body is to serve in the maintanence and recycling...
CymarinNot Annotated
ProscillaridinProscillaridin is a cardiac glycoside that is derived from plants of the genus Scilla and in Drimia maritima (Scilla maritima). Studies suggest the potential cytotoxic and anticancer property of proscillaridin,...
IbopamineNot Annotated
OxyfedrineNot Annotated
MetildigoxinNot Annotated
PrenalterolNot Annotated
PeruvosideNot Annotated
Drugs & Drug Targets
DrugTargetType
MilrinonecGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
DigoxinSodium/potassium-transporting ATPase subunit alpha-1target
DigoxinCholesterol side-chain cleavage enzyme, mitochondrialenzyme
DigoxinP-glycoprotein 1transporter
DigoxinSolute carrier organic anion transporter family member 4C1transporter
DigoxinBile salt export pumptransporter
DigoxinSolute carrier organic anion transporter family member 1A2transporter
DigoxinOrganic solute transporter subunit alphatransporter
DigoxinOrganic solute transporter subunit betatransporter
DigoxinSolute carrier organic anion transporter family member 1B1transporter
DexrazoxaneDNA topoisomerase 2-alphatarget
DexrazoxaneDNA topoisomerase 2-betatarget
PhenylephrineAlpha-1A adrenergic receptortarget
PhenylephrineAlpha-1B adrenergic receptortarget
PhenylephrineAmine oxidase [flavin-containing] Aenzyme
PhenylephrineAlpha-1D adrenergic receptortarget
PhenylephrineCytochrome P450 1A2enzyme
PhenylephrineSulfotransferase 1A3/1A4enzyme
PhenylephrineAmine oxidase [flavin-containing] Benzyme
CarbamoylcholineMuscarinic acetylcholine receptor M1target
CarbamoylcholineMuscarinic acetylcholine receptor M2target
CarbamoylcholineNeuronal acetylcholine receptor subunit alpha-2target
CarbamoylcholineCytosolic phospholipase A2enzyme
CarbamoylcholineAcetylcholinesterasetarget
CarbamoylcholineMuscarinic acetylcholine receptor M3target
CarbamoylcholineMuscarinic acetylcholine receptor M4target
AcetyldigitoxinSodium/potassium-transporting ATPase subunit alpha-1target
LisinoprilAngiotensin-converting enzymetarget
LisinoprilSolute carrier family 15 member 1transporter
LisinoprilSolute carrier family 15 member 2transporter
LisinoprilRenintarget
DobutamineBeta-1 adrenergic receptortarget
DobutamineCatechol O-methyltransferaseenzyme
DobutamineBeta-2 adrenergic receptortarget
DobutamineAlpha-1 adrenergic receptorstarget
DobutamineEstrogen receptor alphatarget
LevosimendanTroponin C, slow skeletal and cardiac musclestarget
LevosimendanATP-sensitive inward rectifier potassium channel 11target
LevosimendanATP-sensitive inward rectifier potassium channel 8target
LevosimendancGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
DopamineDopamine D1 receptortarget
DopamineDopamine beta-hydroxylasetarget
DopamineAmine oxidase [flavin-containing] Aenzyme
DopamineAmine oxidase [flavin-containing] Benzyme
DopamineCatechol O-methyltransferaseenzyme
DopamineSolute carrier family 22 member 2transporter
DopamineSolute carrier family 22 member 1transporter
DopamineSolute carrier family 22 member 3transporter
DopamineSolute carrier family 22 member 5transporter
DopaminePOU domain, class 5, transcription factor 1transporter
DopamineDopamine D5 receptortarget
DopamineDopamine D2 receptortarget
DopamineDopamine D3 receptortarget
DopamineDopamine D4 receptortarget
DopamineSodium-dependent dopamine transportertarget
DopamineDopamine beta-hydroxylaseenzyme
Dopamine5-hydroxytryptamine receptor 1Atarget
Dopamine5-hydroxytryptamine receptor 7target
DopamineD(1) dopamine receptortarget
DopamineSodium-dependent noradrenaline transportertarget
DopamineSodium-dependent serotonin transportertarget
Dopamine5-hydroxytryptamine receptor 3Atarget
Dopamine5-hydroxytryptamine receptor 3Btarget
DopamineSuperoxide dismutase [Cu-Zn]target
DopamineSynaptic vesicular amine transportertarget
IsoprenalineBeta-1 adrenergic receptortarget
IsoprenalineBeta-2 adrenergic receptortarget
IsoprenalinePhosphatidylinositol 3-kinase regulatory subunit alphatarget
IsoprenalineBeta-3 adrenergic receptortarget
IsoprenalineMitogen-activated protein kinase 1target
IsoprenalinePhosphatidylinositol 3-kinase regulatory subunit betatarget
IsoprenalinePhosphatidylinositol 3-kinase regulatory subunit gammatarget
IsoprenalineCytochrome P450 1A1enzyme
IsoprenalineCAMP phosphodiesterasetarget
IsoprenalineSuperoxide dismutase [Cu-Zn]target
DeslanosideSodium/potassium-transporting ATPase subunit alpha-1target
OuabainSodium/potassium-transporting ATPase subunit alpha-1target
OuabainSolute carrier organic anion transporter family member 1A2transporter
OuabainSolute carrier family 22 member 8transporter
OuabainSolute carrier organic anion transporter family member 4C1transporter
OuabainSolute carrier organic anion transporter family member 1B3transporter
OuabainSolute carrier organic anion transporter family member 1C1transporter
OuabainSolute carrier organic anion transporter family member 1B1transporter
OuabainSodium/potassium-transporting ATPase subunit alpha-2target
OuabainSodium/potassium-transporting ATPase subunit alpha-3target
ArbutamineBeta-1 adrenergic receptortarget
ArbutamineBeta-2 adrenergic receptortarget
ArbutamineBeta-3 adrenergic receptortarget
AminophyllinecGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
AminophyllineAdenosine receptor A3target
AminophyllineAdenosine receptor A1target
AminophyllineCytochrome P450 1A2enzyme
AminophyllineCytochrome P450 2E1enzyme
AminophyllineCytochrome P450 3A4enzyme
AminophyllineHistone deacetylase 2target
PirbuterolBeta-2 adrenergic receptortarget
PirbuterolBeta-1 adrenergic receptortarget
DigitoxinSodium/potassium-transporting ATPase subunit alpha-1target
DigitoxinSerum albumincarrier
DigitoxinCholesterol side-chain cleavage enzyme, mitochondrialenzyme
DigitoxinCytochrome P450 3A4enzyme
DigitoxinSolute carrier organic anion transporter family member 1A2transporter
DigitoxinSolute carrier organic anion transporter family member 4C1transporter
DigitoxinP-glycoprotein 1transporter
AmrinonecAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
AmrinoneTumor necrosis factortarget
AmrinonecGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
AmrinonecGMP-inhibited 3',5'-cyclic phosphodiesterase Btarget
ColforsinP-glycoprotein 1transporter
ColforsinAdenylate cyclase type 2target
ColforsinGuanine nucleotide-binding protein G(s) subunit alpha isoforms shorttarget
ColforsinAdenylate cyclase type 5target
ColforsinCystic fibrosis transmembrane conductance regulatortarget
EnoximonecGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
CanertinibEpidermal growth factor receptortarget
PimobendanCytochrome P450 1A2enzyme
PhosphocreatineGuanidinoacetate N-methyltransferasetarget
PhosphocreatineSodium- and chloride-dependent creatine transporter 1target
PhosphocreatineCreatine kinase M-typetarget
PhosphocreatineCreatine kinase U-type, mitochondrialtarget
PhosphocreatineCreatine kinase S-type, mitochondrialtarget
PhosphocreatineCreatine kinase B-typetarget