Inhibitors of reverse transcriptase (RNA-DIRECTED DNA POLYMERASE), an enzyme that synthesizes DNA on an RNA template.
DrugDrug NameDrug Indication
DB11948LapachoneNot Available
DB12074CensavudineNot Available
DB12264AtevirdineNot Available
DB12531LobucavirNot Available
DB12539OltiprazNot Available
DB00238NevirapineFor use in combination with other antiretroviral drugs in the ongoing treatment of HIV-1 infection.
DB00299PenciclovirUsed to treat recurrent cold sores on the lips and face from various herpesvirus invections.
DB00300Tenofovir disoproxilTenofovir is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection in adults and pediatric patients 2 years of age and older. It is also indicated for the treatment of chronic hepatitis B in adults and pediatric patients 12 years of age and older.
DB00495ZidovudineUsed in combination with other antiretroviral agents for the treatment of human immunovirus (HIV) infections.
DB00529FoscarnetFor the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS) and for treatment of acyclovir-resistant mucocutaneous HSV infections in immunocompromised patients.
DB00625EfavirenzFor use in combination treatment of HIV infection (AIDS)
DB00649StavudineFor the treatment of human immunovirus (HIV) infections.
DB00705DelavirdineFor the treatment of HIV-1 infection in combination with appropriate antiretroviral agents when therapy is warranted
DB00709LamivudineFor the treatment of HIV infection and chronic hepatitis B (HBV).
DB00718Adefovir DipivoxilFor the treatment of chronic hepatitis B in adults with evidence of active viral replication and either evidence of persistent elevations in serum aminotransferases (ALT or AST) or histologically active disease.
DB00879EmtricitabineIndicated, in combination with other antiretroviral agents, for the treatment of HIV-1 infection in adults and for postexposure prophylaxis of HIV infection in health care workers and others exposed occupationally or nonoccupationally via percutaneous injury or mucous membrane or nonintact skin contact with blood, tissues, or other body fluids associated with risk for transmission of the virus.
DB00900DidanosineFor use, in combination with other antiretroviral agents, in the treatment of HIV-1 infection in adults.
DB00943ZalcitabineFor the treatment of Human immunovirus (HIV) infections in conjunction with other antivirals.
DB01048AbacavirFor the treatment of HIV-1 infection, in combination with other antiretroviral agents.
DB02823Phosphonoacetic AcidNot Available
DB06414EtravirineIndicated as an adjunct therapy in the treatment of adult HIV-1 infections resistant to therapy with other NNRTIs and antiretroviral agents.
DB08864RilpivirineTreatment of HIV-1 infections in treatment-naive patients with HIV-1 RNA ≤100,000 copies/mL in combination with at least 2 other antiretroviral agents.
DrugDrug NameTargetType
DB00238NevirapineCytochrome P450 3A4enzyme
DB00238NevirapineCytochrome P450 2B6enzyme
DB00238NevirapineCytochrome P450 3A5enzyme
DB00238NevirapineCytochrome P450 2C9enzyme
DB00238NevirapineCytochrome P450 2A6enzyme
DB00238NevirapineCytochrome P450 2D6enzyme
DB00238NevirapineCytochrome P450 1A2enzyme
DB00238NevirapineReverse transcriptase/RNaseHtarget
DB00238NevirapineSerum albumincarrier
DB00299PenciclovirDNA polymerase catalytic subunittarget
DB00299PenciclovirThymidine kinasetarget
DB00300Tenofovir disoproxilReverse transcriptase/RNaseHtarget
DB00300Tenofovir disoproxilCytochrome P450 1A2enzyme
DB00300Tenofovir disoproxilSolute carrier family 22 member 6transporter
DB00300Tenofovir disoproxilSolute carrier family 22 member 8transporter
DB00300Tenofovir disoproxilMultidrug resistance-associated protein 7transporter
DB00300Tenofovir disoproxilMultidrug resistance-associated protein 4transporter
DB00300Tenofovir disoproxilCanalicular multispecific organic anion transporter 1transporter
DB00300Tenofovir disoproxilAdenylate kinase 2, mitochondrialenzyme
DB00300Tenofovir disoproxilAdenylate kinase 4, mitochondrialenzyme
DB00300Tenofovir disoproxilNucleoside diphosphate kinase Aenzyme
DB00300Tenofovir disoproxilNucleoside diphosphate kinase Benzyme
DB00495ZidovudineSerum albumincarrier
DB00495ZidovudineCytochrome P450 2A6enzyme
DB00495ZidovudineCytochrome P450 2C19enzyme
DB00495ZidovudineCytochrome P450 2C8enzyme
DB00495ZidovudineCytochrome P450 2C9enzyme
DB00495ZidovudineCytochrome P450 3A4enzyme
DB00495ZidovudineReverse transcriptase/RNaseHtarget
DB00495ZidovudineSolute carrier family 22 member 2transporter
DB00495ZidovudineSolute carrier family 22 member 6transporter
DB00495ZidovudineSolute carrier family 22 member 7transporter
DB00495ZidovudineSolute carrier family 22 member 8transporter
DB00495ZidovudineSolute carrier family 22 member 11transporter
DB00495ZidovudineSodium/nucleoside cotransporter 1transporter
DB00495ZidovudineEquilibrative nucleoside transporter 2transporter
DB00495ZidovudineMultidrug resistance protein 1transporter
DB00495ZidovudineMultidrug resistance-associated protein 4transporter
DB00495ZidovudineMultidrug resistance-associated protein 5transporter
DB00495ZidovudineATP-binding cassette sub-family G member 2transporter
DB00495ZidovudineTelomerase reverse transcriptasetarget
DB00495ZidovudineThymidine kinase, cytosolicenzyme
DB00495ZidovudineUDP-glucuronosyltransferase 2B7enzyme
DB00529FoscarnetDNA polymerase catalytic subunittarget
DB00529FoscarnetDNA polymerase catalytic subunittarget
DB00529FoscarnetSolute carrier family 22 member 6transporter
DB00529FoscarnetMonocarboxylate transporter 1transporter
DB00625EfavirenzCytochrome P450 2B6enzyme
DB00625EfavirenzCytochrome P450 3A4enzyme
DB00625EfavirenzCytochrome P450 2C19enzyme
DB00625EfavirenzCytochrome P450 2C9enzyme
DB00625EfavirenzCytochrome P450 1A2enzyme
DB00625EfavirenzCytochrome P450 2D6enzyme
DB00625EfavirenzReverse transcriptase/RNaseHtarget
DB00625EfavirenzCytochrome P450 2C8enzyme
DB00625EfavirenzSerum albumincarrier
DB00649StavudineSolute carrier family 22 member 6transporter
DB00649StavudineReverse transcriptase/RNaseHtarget
DB00649StavudineSodium/nucleoside cotransporter 1transporter
DB00649StavudineSerum albumincarrier
DB00705DelavirdineCytochrome P450 3A4enzyme
DB00705DelavirdineCytochrome P450 2C9enzyme
DB00705DelavirdineCytochrome P450 2D6enzyme
DB00705DelavirdineCytochrome P450 3A5enzyme
DB00705DelavirdineCytochrome P450 3A7enzyme
DB00705DelavirdineCytochrome P450 2C19enzyme
DB00705DelavirdineCytochrome P450 1A2enzyme
DB00705DelavirdineCytochrome P450 2C8enzyme
DB00705DelavirdineReverse transcriptase/RNaseHtarget
DB00709LamivudineDNAtarget
DB00709LamivudineProtein Ptarget
DB00709LamivudineMultidrug resistance-associated protein 1transporter
DB00709LamivudineSolute carrier family 22 member 6transporter
DB00709LamivudineATP-binding cassette sub-family G member 2transporter
DB00709LamivudineReverse transcriptase/RNaseHtarget
DB00709LamivudineSolute carrier family 22 member 1transporter
DB00709LamivudineSolute carrier family 22 member 2transporter
DB00709LamivudineSolute carrier family 22 member 3transporter
DB00709LamivudineDeoxycytidine kinaseenzyme
DB00709LamivudineUMP-CMP kinaseenzyme
DB00709LamivudinePhosphoglycerate kinase 1enzyme
DB00709LamivudineNucleoside diphosphate kinase Aenzyme
DB00709LamivudineNucleoside diphosphate kinase Benzyme
DB00709LamivudineCholine-phosphate cytidylyltransferase Aenzyme
DB00709LamivudineEthanolamine-phosphate cytidylyltransferaseenzyme
DB00709LamivudineMultidrug resistance protein 1transporter
DB00709LamivudineMultidrug resistance-associated protein 4transporter
DB00709LamivudineCanalicular multispecific organic anion transporter 2transporter
DB00709LamivudineCanalicular multispecific organic anion transporter 1transporter
DB00709Lamivudine5'(3')-deoxyribonucleotidase, cytosolic typeenzyme
DB00709LamivudineSerum albumincarrier
DB00718Adefovir DipivoxilDNA polymerase/reverse transcriptasetarget
DB00718Adefovir DipivoxilSolute carrier family 22 member 6transporter
DB00718Adefovir DipivoxilMultidrug resistance-associated protein 4transporter
DB00718Adefovir DipivoxilMultidrug resistance-associated protein 5transporter
DB00718Adefovir DipivoxilSolute carrier family 22 member 3transporter
DB00718Adefovir DipivoxilAdenylate kinase 2, mitochondrialenzyme
DB00718Adefovir DipivoxilAdenylate kinase 4, mitochondrialenzyme
DB00718Adefovir DipivoxilNucleoside diphosphate kinase Aenzyme
DB00718Adefovir DipivoxilNucleoside diphosphate kinase Benzyme
DB00718Adefovir DipivoxilSolute carrier family 22 member 8transporter
DB00879EmtricitabineReverse transcriptase/RNaseHtarget
DB00879EmtricitabineDeoxycytidine kinaseenzyme
DB00879EmtricitabineSerum albumincarrier
DB00900DidanosineSolute carrier family 22 member 6transporter
DB00900DidanosinePurine nucleoside phosphorylasetarget
DB00900DidanosineReverse transcriptase/RNaseHtarget
DB00900DidanosineEquilibrative nucleoside transporter 1transporter
DB00900DidanosineEquilibrative nucleoside transporter 2transporter
DB00900DidanosineSerum albumincarrier
DB00943ZalcitabineDeoxycytidine kinaseenzyme
DB00943ZalcitabineSolute carrier family 22 member 6transporter
DB00943ZalcitabineSolute carrier family 22 member 7transporter
DB00943ZalcitabineCytochrome P450 2C9enzyme
DB00943ZalcitabineCytochrome P450 2D6enzyme
DB00943ZalcitabineCytochrome P450 3A4enzyme
DB00943ZalcitabineCytochrome P450 3A43enzyme
DB00943ZalcitabineCytochrome P450 3A5enzyme
DB00943ZalcitabineCytochrome P450 3A7enzyme
DB00943ZalcitabineReverse transcriptase/RNaseHtarget
DB00943ZalcitabineEquilibrative nucleoside transporter 1transporter
DB00943ZalcitabineEquilibrative nucleoside transporter 2transporter
DB00943ZalcitabineSerum albumincarrier
DB01048AbacavirAlcohol dehydrogenase 6enzyme
DB01048AbacavirUDP-glucuronosyltransferase 1-1enzyme
DB01048AbacavirReverse transcriptase/RNaseHtarget
DB01048AbacavirAdenosine kinaseenzyme
DB01048AbacavirHLA class I histocompatibility antigen, B-57 alpha chaintarget
DB02823Phosphonoacetic AcidAlkaline phosphatasetarget
DB06414EtravirineCytochrome P450 2C19enzyme
DB06414EtravirineCytochrome P450 2C9enzyme
DB06414EtravirineCytochrome P450 3A4enzyme
DB06414EtravirineGag-Pol polyproteintarget
DB06414EtravirineGag-Pol polyproteintarget
DB06414EtravirineMultidrug resistance protein 1transporter
DB06414EtravirineMultidrug resistance protein 3transporter
DB08864RilpivirineCytochrome P450 3A4enzyme
DB08864RilpivirineReverse transcriptase/RNaseHtarget
DB08864RilpivirineNuclear receptor subfamily 1 group I member 2target
DB08864RilpivirineCytochrome P450 2C19enzyme
DB08864RilpivirineCytochrome P450 2B6enzyme
DB08864RilpivirineCytochrome P450 1A2enzyme
DB08864RilpivirineMultidrug resistance protein 1transporter
DB08864RilpivirineATP-binding cassette sub-family G member 2transporter
DB08864RilpivirineSolute carrier organic anion transporter family member 1B1transporter
DB08864RilpivirineSolute carrier organic anion transporter family member 1B3transporter