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Identification
NameDelavirdine
Accession NumberDB00705  (APRD00149, DB08563)
TypeSmall Molecule
GroupsApproved
DescriptionA potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. [PubChem]
Structure
Thumb
Synonyms
(N-[2-[4-[3-(1-Methylethylamino)pyridin-2-yl]piperazin-1-yl]carbonyl-1H-indol-5-yl] methanesulfonamide)
1-(3-((1-Methylethyl)amino)-2-pyridinyl)-4-((5-((methylsulfonyl)amino)-1H-indol-2-yl)carbonyl)piperazine
2-(4-(5-Methanesulfonamido-1H-indol-2-ylcarbonyl)-1-piperazinyl)-N-(1-methylethyl)-3-pyridinamine
Delavirdin
Delavirdina
Delavirdine
Delavirdinum
N-(2-(1-(3-(Isopropylamino)pyridin-2-yl)piperazine-4-carbonyl)-1H-indol-5-yl)methanesulfonamide
N-{2-[4-(3-isopropylamino-pyridin-2-yl)-piperazine-1-carbonyl]-1H-indol-5-yl}-methanesulfonamide
External Identifiers
  • U 90152 S
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
RescriptorTablet200 mg/1OralKAISER FOUNDATION HOSPITALS2011-07-06Not applicableUs
RescriptorTablet100 mgOralViiv Healthcare Ulc1998-07-24Not applicableCanada
RescriptorTablet100 mg/1OralVii V Healthcare Company2010-10-13Not applicableUs
RescriptorTablet200 mg/1OralVii V Healthcare Company2010-10-13Not applicableUs
RescriptorTablet200 mg/1OralVii V Healthcare Company2012-04-11Not applicableUs
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Delavirdine mesylate
147221-93-0
Thumb
  • InChI Key: MEPNHSOMXMALDZ-UHFFFAOYSA-N
  • Monoisotopic Mass: 552.182474166
  • Average Mass: 552.667
DBSALT000038
Categories
UNIIDOL5F9JD3E
CAS number136817-59-9
WeightAverage: 456.561
Monoisotopic: 456.194359482
Chemical FormulaC22H28N6O3S
InChI KeyWHBIGIKBNXZKFE-UHFFFAOYSA-N
InChI
InChI=1S/C22H28N6O3S/c1-15(2)24-19-5-4-8-23-21(19)27-9-11-28(12-10-27)22(29)20-14-16-13-17(26-32(3,30)31)6-7-18(16)25-20/h4-8,13-15,24-26H,9-12H2,1-3H3
IUPAC Name
N-[2-(4-{3-[(propan-2-yl)amino]pyridin-2-yl}piperazine-1-carbonyl)-1H-indol-5-yl]methanesulfonamide
SMILES
CC(C)NC1=C(N=CC=C1)N1CCN(CC1)C(=O)C1=CC2=C(N1)C=CC(NS(C)(=O)=O)=C2
Pharmacology
IndicationFor the treatment of HIV-1 infection in combination with appropriate antiretroviral agents when therapy is warranted
Structured Indications
PharmacodynamicsDelavirdine is a non-nucleoside reverse transcriptase inhibitor (nNRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Delavirdine binds directly to reverse transcriptase (RT) and blocks the RNA-dependent and DNA-dependent DNA polymerase activities by causing a disruption of the enzyme's catalytic site. The activity of Delavirdine does not compete with template or nucleoside triphosphates. HIV-2 RT and eukaryotic DNA polymerases (such as human DNA polymerases alpha, beta, or sigma) are not inhibited by Delavirdine.
Mechanism of actionDelavirdine binds directly to viral reverse transcriptase (RT) and blocks the RNA-dependent and DNA-dependent DNA polymerase activities by disrupting the enzyme's catalytic site.
TargetKindPharmacological actionActionsOrganismUniProt ID
Reverse transcriptase/RNaseHProteinyes
inhibitor
Human immunodeficiency virus 1Q72547 details
Related Articles
AbsorptionRapidly absorbed
Volume of distributionNot Available
Protein binding98%
Metabolism

Hepatic

SubstrateEnzymesProduct
Delavirdine
N-desalkyl delavirdineDetails
Route of eliminationDelavirdine is extensively converted to several inactive metabolites by cytochrome P450 3A (CYP3A). Delavirdine was excreted in the milk of lactating rats at a concentration three to five times that of rat plasma.
Half life5.8 hours
ClearanceNot Available
ToxicityMajor toxicity of delavirdine is rash and should be advised to promptly notify their physician should rash occur. The majority of rashes associated with delavirdine occur within 1 to 3 weeks after initiating treatment with delavirdine. The rash normally resolves in 3 to 14 days and may be treated symptomatically while therapy with delavirdine is continued. Any patient experiencing severe rash or rash accompanied by symptoms such as fever, blistering, oral lesions, conjunctivitis, swelling, muscle or joint aches should discontinue medication and consult a physician.
Affected organisms
  • Human Immunodeficiency Virus
Pathways
PathwayCategorySMPDB ID
Delavirdine Action PathwayDrug actionSMP00738
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
1,10-PhenanthrolineThe serum concentration of Delavirdine can be decreased when it is combined with 1,10-Phenanthroline.Experimental
3,4-DichloroisocoumarinThe serum concentration of Delavirdine can be decreased when it is combined with 3,4-Dichloroisocoumarin.Experimental
4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDEThe serum concentration of Delavirdine can be decreased when it is combined with 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE.Experimental
4-MethoxyamphetamineThe metabolism of 4-Methoxyamphetamine can be decreased when combined with Delavirdine.Experimental, Illicit
AbirateroneThe serum concentration of Delavirdine can be increased when it is combined with Abiraterone.Approved
AceclofenacThe metabolism of Aceclofenac can be decreased when combined with Delavirdine.Approved
AcenocoumarolThe metabolism of Acenocoumarol can be decreased when combined with Delavirdine.Approved
AcetaminophenThe metabolism of Acetaminophen can be decreased when combined with Delavirdine.Approved
AcetylcholineThe metabolism of Acetylcholine can be decreased when combined with Delavirdine.Approved
Acetylsalicylic acidThe metabolism of Acetylsalicylic acid can be decreased when combined with Delavirdine.Approved, Vet Approved
AdinazolamThe metabolism of Adinazolam can be decreased when combined with Delavirdine.Approved
AjmalineThe metabolism of Ajmaline can be decreased when combined with Delavirdine.Approved
AlbendazoleThe metabolism of Albendazole can be decreased when combined with Delavirdine.Approved, Vet Approved
AlclometasoneThe metabolism of Alclometasone can be decreased when combined with Delavirdine.Approved
AlfentanilThe metabolism of Alfentanil can be decreased when combined with Delavirdine.Approved, Illicit
AlfuzosinThe metabolism of Alfuzosin can be decreased when combined with Delavirdine.Approved, Investigational
AliskirenThe metabolism of Aliskiren can be decreased when combined with Delavirdine.Approved, Investigational
AllylestrenolThe metabolism of Allylestrenol can be decreased when combined with Delavirdine.Approved
AlmotriptanThe metabolism of Almotriptan can be decreased when combined with Delavirdine.Approved, Investigational
AlogliptinThe serum concentration of Delavirdine can be decreased when it is combined with Alogliptin.Approved
AlosetronThe metabolism of Alosetron can be decreased when combined with Delavirdine.Approved, Withdrawn
Alpha-1-proteinase inhibitorThe serum concentration of Delavirdine can be decreased when it is combined with Alpha-1-proteinase inhibitor.Approved
AlprazolamThe metabolism of Alprazolam can be decreased when combined with Delavirdine.Approved, Illicit, Investigational
AlprenololThe metabolism of Alprenolol can be decreased when combined with Delavirdine.Approved, Withdrawn
Aluminum hydroxideThe serum concentration of Delavirdine can be decreased when it is combined with Aluminum hydroxide.Approved
Aluminum phosphateThe serum concentration of Delavirdine can be decreased when it is combined with Aluminum phosphate.Approved
AmbrisentanThe metabolism of Ambrisentan can be decreased when combined with Delavirdine.Approved, Investigational
AmbroxolThe metabolism of Ambroxol can be decreased when combined with Delavirdine.Approved
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Delavirdine.Approved, Withdrawn
AminophyllineThe metabolism of Aminophylline can be decreased when combined with Delavirdine.Approved
AmiodaroneThe metabolism of Delavirdine can be decreased when combined with Amiodarone.Approved, Investigational
AmitriptylineThe metabolism of Amitriptyline can be decreased when combined with Delavirdine.Approved
AmlodipineThe metabolism of Amlodipine can be decreased when combined with Delavirdine.Approved
AmodiaquineThe serum concentration of Amodiaquine can be increased when it is combined with Delavirdine.Approved
AmoxapineThe metabolism of Amoxapine can be decreased when combined with Delavirdine.Approved
AmoxicillinThe metabolism of Amoxicillin can be decreased when combined with Delavirdine.Approved, Vet Approved
AmphetamineThe metabolism of Amphetamine can be decreased when combined with Delavirdine.Approved, Illicit
AmprenavirThe serum concentration of Delavirdine can be decreased when it is combined with Amprenavir.Approved
AmsacrineThe metabolism of Amsacrine can be decreased when combined with Delavirdine.Approved
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Delavirdine.Approved
Antithrombin III humanThe serum concentration of Delavirdine can be decreased when it is combined with Antithrombin III human.Approved
ApixabanThe serum concentration of Delavirdine can be decreased when it is combined with Apixaban.Approved
ApremilastThe metabolism of Apremilast can be decreased when combined with Delavirdine.Approved, Investigational
AprepitantThe serum concentration of Delavirdine can be increased when it is combined with Aprepitant.Approved, Investigational
AprindineThe metabolism of Aprindine can be decreased when combined with Delavirdine.Approved
AprotininThe serum concentration of Delavirdine can be decreased when it is combined with Aprotinin.Approved, Withdrawn
Arachidonic AcidThe metabolism of Arachidonic Acid can be decreased when combined with Delavirdine.Experimental
ArformoterolThe metabolism of Arformoterol can be decreased when combined with Delavirdine.Approved, Investigational
ArgatrobanThe serum concentration of Delavirdine can be decreased when it is combined with Argatroban.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Delavirdine.Approved, Investigational
ArtemetherThe metabolism of Artemether can be decreased when combined with Delavirdine.Approved
AsenapineThe serum concentration of Delavirdine can be decreased when it is combined with Asenapine.Approved
AstemizoleDelavirdine may increase the arrhythmogenic activities of Astemizole.Approved, Withdrawn
AsunaprevirThe serum concentration of Delavirdine can be decreased when it is combined with Asunaprevir.Approved, Investigational
AtazanavirThe serum concentration of Delavirdine can be decreased when it is combined with Atazanavir.Approved, Investigational
AtomoxetineThe serum concentration of Atomoxetine can be increased when it is combined with Delavirdine.Approved
AtorvastatinThe metabolism of Atorvastatin can be decreased when combined with Delavirdine.Approved
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Delavirdine.Approved
AxitinibThe metabolism of Axitinib can be decreased when combined with Delavirdine.Approved, Investigational
AzelastineThe metabolism of Azelastine can be decreased when combined with Delavirdine.Approved
AzithromycinThe metabolism of Azithromycin can be decreased when combined with Delavirdine.Approved
BanoxantroneThe metabolism of Banoxantrone can be decreased when combined with Delavirdine.Investigational
BatimastatThe serum concentration of Delavirdine can be decreased when it is combined with Batimastat.Experimental
BedaquilineThe metabolism of Bedaquiline can be decreased when combined with Delavirdine.Approved
BenazeprilThe serum concentration of Delavirdine can be decreased when it is combined with Benazepril.Approved, Investigational
BenzamidineThe serum concentration of Delavirdine can be decreased when it is combined with Benzamidine.Experimental
BenzatropineThe metabolism of Benzatropine can be decreased when combined with Delavirdine.Approved
BenzphetamineThe metabolism of Benzphetamine can be decreased when combined with Delavirdine.Approved, Illicit
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Delavirdine.Approved
BepridilThe metabolism of Bepridil can be decreased when combined with Delavirdine.Approved, Withdrawn
BetaxololThe metabolism of Betaxolol can be decreased when combined with Delavirdine.Approved
BexaroteneThe metabolism of Bexarotene can be decreased when combined with Delavirdine.Approved, Investigational
BezafibrateThe metabolism of Bezafibrate can be decreased when combined with Delavirdine.Approved
Bi201335The serum concentration of Delavirdine can be decreased when it is combined with Bi201335.Investigational
BicalutamideThe metabolism of Bicalutamide can be decreased when combined with Delavirdine.Approved
Bismuth SubcitrateThe serum concentration of Delavirdine can be decreased when it is combined with Bismuth Subcitrate.Approved
BisoprololThe metabolism of Bisoprolol can be decreased when combined with Delavirdine.Approved
BivalirudinThe serum concentration of Delavirdine can be decreased when it is combined with Bivalirudin.Approved, Investigational
BoceprevirThe serum concentration of Delavirdine can be decreased when it is combined with Boceprevir.Approved
BortezomibThe metabolism of Bortezomib can be decreased when combined with Delavirdine.Approved, Investigational
BosentanThe serum concentration of Bosentan can be increased when it is combined with Delavirdine.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Delavirdine.Approved
Brentuximab vedotinThe metabolism of Brentuximab vedotin can be decreased when combined with Delavirdine.Approved
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Delavirdine.Approved
BrinzolamideThe metabolism of Brinzolamide can be decreased when combined with Delavirdine.Approved
BromazepamThe metabolism of Bromazepam can be decreased when combined with Delavirdine.Approved, Illicit
BromocriptineThe metabolism of Bromocriptine can be decreased when combined with Delavirdine.Approved, Investigational
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Delavirdine.Approved
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Delavirdine.Approved
BudesonideThe metabolism of Budesonide can be decreased when combined with Delavirdine.Approved
BufuralolThe metabolism of Bufuralol can be decreased when combined with Delavirdine.Experimental, Investigational
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Delavirdine.Approved, Investigational
BuprenorphineThe metabolism of Buprenorphine can be decreased when combined with Delavirdine.Approved, Illicit, Investigational, Vet Approved
BupropionThe metabolism of Bupropion can be decreased when combined with Delavirdine.Approved
BuspironeThe metabolism of Buspirone can be decreased when combined with Delavirdine.Approved, Investigational
BusulfanThe metabolism of Busulfan can be decreased when combined with Delavirdine.Approved, Investigational
CabazitaxelThe metabolism of Cabazitaxel can be decreased when combined with Delavirdine.Approved
CabergolineThe metabolism of Cabergoline can be decreased when combined with Delavirdine.Approved
CabozantinibThe metabolism of Cabozantinib can be decreased when combined with Delavirdine.Approved
CaffeineThe metabolism of Caffeine can be decreased when combined with Delavirdine.Approved
CalcitriolThe metabolism of Calcitriol can be decreased when combined with Delavirdine.Approved, Nutraceutical
Calcium carbonateThe serum concentration of Delavirdine can be decreased when it is combined with Calcium carbonate.Approved
CanagliflozinThe metabolism of Canagliflozin can be decreased when combined with Delavirdine.Approved
CandesartanThe metabolism of Candesartan can be decreased when combined with Delavirdine.Approved
CandoxatrilThe serum concentration of Delavirdine can be decreased when it is combined with Candoxatril.Experimental
CandoxatrilatThe serum concentration of Delavirdine can be decreased when it is combined with Candoxatrilat.Experimental
CaptoprilThe serum concentration of Delavirdine can be decreased when it is combined with Captopril.Approved
CarbamazepineThe serum concentration of Delavirdine can be decreased when it is combined with Carbamazepine.Approved, Investigational
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Delavirdine.Approved
CariprazineThe metabolism of Cariprazine can be decreased when combined with Delavirdine.Approved
CarisoprodolThe metabolism of Carisoprodol can be decreased when combined with Delavirdine.Approved
CarteololThe metabolism of Carteolol can be decreased when combined with Delavirdine.Approved
CarvedilolThe serum concentration of Carvedilol can be increased when it is combined with Delavirdine.Approved, Investigational
CelecoxibThe metabolism of Celecoxib can be decreased when combined with Delavirdine.Approved, Investigational
CeliprololThe metabolism of Celiprolol can be decreased when combined with Delavirdine.Approved, Investigational
CephalexinThe metabolism of Cephalexin can be decreased when combined with Delavirdine.Approved, Vet Approved
CeritinibThe serum concentration of Delavirdine can be increased when it is combined with Ceritinib.Approved
CerivastatinThe metabolism of Cerivastatin can be decreased when combined with Delavirdine.Withdrawn
CevimelineThe metabolism of Cevimeline can be decreased when combined with Delavirdine.Approved
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be decreased when combined with Delavirdine.Approved
ChloramphenicolThe metabolism of Chloramphenicol can be decreased when combined with Delavirdine.Approved, Vet Approved
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Delavirdine.Approved, Illicit
ChloroquineThe metabolism of Chloroquine can be decreased when combined with Delavirdine.Approved, Vet Approved
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Delavirdine.Approved
ChlorpromazineThe metabolism of Chlorpromazine can be decreased when combined with Delavirdine.Approved, Vet Approved
ChlorpropamideThe metabolism of Chlorpropamide can be decreased when combined with Delavirdine.Approved
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Delavirdine.Approved
CholecalciferolThe metabolism of Cholecalciferol can be decreased when combined with Delavirdine.Approved, Nutraceutical
ChymostatinThe serum concentration of Delavirdine can be decreased when it is combined with Chymostatin.Experimental
CiclesonideThe metabolism of Ciclesonide can be decreased when combined with Delavirdine.Approved, Investigational
CilastatinThe serum concentration of Delavirdine can be decreased when it is combined with Cilastatin.Approved
CilazaprilThe serum concentration of Delavirdine can be decreased when it is combined with Cilazapril.Approved
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Delavirdine.Approved
CimetidineThe serum concentration of Delavirdine can be decreased when it is combined with Cimetidine.Approved
CinacalcetThe metabolism of Delavirdine can be decreased when combined with Cinacalcet.Approved
CinnarizineThe metabolism of Cinnarizine can be decreased when combined with Delavirdine.Approved
CisaprideThe metabolism of Cisapride can be decreased when combined with Delavirdine.Approved, Investigational, Withdrawn
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Delavirdine.Approved
ClarithromycinThe metabolism of Delavirdine can be decreased when combined with Clarithromycin.Approved
ClemastineThe metabolism of Delavirdine can be decreased when combined with Clemastine.Approved
ClevidipineThe metabolism of Clevidipine can be decreased when combined with Delavirdine.Approved
ClindamycinThe metabolism of Clindamycin can be decreased when combined with Delavirdine.Approved, Vet Approved
ClobazamThe metabolism of Clobazam can be decreased when combined with Delavirdine.Approved, Illicit
ClofazimineThe metabolism of Clofazimine can be decreased when combined with Delavirdine.Approved, Investigational
ClofibrateThe metabolism of Clofibrate can be decreased when combined with Delavirdine.Approved
clomethiazoleThe metabolism of clomethiazole can be decreased when combined with Delavirdine.Investigational
ClomipramineThe metabolism of Clomipramine can be decreased when combined with Delavirdine.Approved, Vet Approved
ClonazepamThe metabolism of Clonazepam can be decreased when combined with Delavirdine.Approved, Illicit
ClonidineThe metabolism of Clonidine can be decreased when combined with Delavirdine.Approved
ClopidogrelThe serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Delavirdine resulting in a loss in efficacy.Approved, Nutraceutical
ClorazepateThe metabolism of Clorazepate can be decreased when combined with Delavirdine.Approved, Illicit
ClotiazepamThe metabolism of Clotiazepam can be decreased when combined with Delavirdine.Approved, Illicit
ClotrimazoleThe metabolism of Delavirdine can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineThe metabolism of Clozapine can be decreased when combined with Delavirdine.Approved
CobicistatThe serum concentration of Delavirdine can be increased when it is combined with Cobicistat.Approved
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Delavirdine.Approved
CocaineThe metabolism of Delavirdine can be decreased when combined with Cocaine.Approved, Illicit
CodeineThe therapeutic efficacy of Codeine can be decreased when used in combination with Delavirdine.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Delavirdine.Approved
ConivaptanThe serum concentration of Delavirdine can be increased when it is combined with Conivaptan.Approved, Investigational
Conjugated Equine EstrogensThe metabolism of Conjugated Equine Estrogens can be decreased when combined with Delavirdine.Approved
Cortisone acetateThe metabolism of Cortisone acetate can be decreased when combined with Delavirdine.Approved
CrizotinibThe metabolism of Crizotinib can be decreased when combined with Delavirdine.Approved
CyclobenzaprineThe metabolism of Cyclobenzaprine can be decreased when combined with Delavirdine.Approved
CyclophosphamideThe metabolism of Cyclophosphamide can be decreased when combined with Delavirdine.Approved, Investigational
CyclosporineThe metabolism of Delavirdine can be decreased when combined with Cyclosporine.Approved, Investigational, Vet Approved
CytarabineThe metabolism of Cytarabine can be decreased when combined with Delavirdine.Approved, Investigational
Dabigatran etexilateThe serum concentration of Delavirdine can be decreased when it is combined with Dabigatran etexilate.Approved
DabrafenibThe serum concentration of Delavirdine can be decreased when it is combined with Dabrafenib.Approved
DaclatasvirThe metabolism of Daclatasvir can be decreased when combined with Delavirdine.Approved
DantroleneThe metabolism of Dantrolene can be decreased when combined with Delavirdine.Approved
DapagliflozinThe metabolism of Dapagliflozin can be decreased when combined with Delavirdine.Approved
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Delavirdine.Investigational
DapsoneThe metabolism of Dapsone can be decreased when combined with Delavirdine.Approved, Investigational
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Delavirdine.Approved, Investigational
DarunavirThe serum concentration of Delavirdine can be decreased when it is combined with Darunavir.Approved
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Delavirdine.Approved
DasatinibThe serum concentration of Delavirdine can be increased when it is combined with Dasatinib.Approved, Investigational
DaunorubicinThe metabolism of Daunorubicin can be decreased when combined with Delavirdine.Approved
DebrisoquinThe metabolism of Debrisoquin can be decreased when combined with Delavirdine.Approved
DeferasiroxThe serum concentration of Delavirdine can be decreased when it is combined with Deferasirox.Approved, Investigational
DesipramineThe metabolism of Desipramine can be decreased when combined with Delavirdine.Approved
DesvenlafaxineThe metabolism of Desvenlafaxine can be decreased when combined with Delavirdine.Approved
DexamethasoneThe serum concentration of Delavirdine can be decreased when it is combined with Dexamethasone.Approved, Investigational, Vet Approved
DexfenfluramineThe metabolism of Dexfenfluramine can be decreased when combined with Delavirdine.Approved, Illicit, Withdrawn
DexmethylphenidateThe metabolism of Dexmethylphenidate can be decreased when combined with Delavirdine.Approved
DextroamphetamineThe metabolism of Dextroamphetamine can be decreased when combined with Delavirdine.Approved, Illicit
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Delavirdine.Approved
DextropropoxypheneThe metabolism of Dextropropoxyphene can be decreased when combined with Delavirdine.Approved, Illicit, Withdrawn
DiazepamThe metabolism of Diazepam can be decreased when combined with Delavirdine.Approved, Illicit, Vet Approved
DiclofenacThe metabolism of Diclofenac can be decreased when combined with Delavirdine.Approved, Vet Approved
DiclofenacThe serum concentration of Diclofenac can be increased when it is combined with Delavirdine.Approved, Vet Approved
DicoumarolThe metabolism of Dicoumarol can be decreased when combined with Delavirdine.Approved
DigitoxinThe metabolism of Digitoxin can be decreased when combined with Delavirdine.Approved
DigoxinThe metabolism of Digoxin can be decreased when combined with Delavirdine.Approved
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Delavirdine.Approved, Illicit
DihydroergotamineThe metabolism of Delavirdine can be decreased when combined with Dihydroergotamine.Approved
DiltiazemThe metabolism of Diltiazem can be decreased when combined with Delavirdine.Approved
DiphenhydramineThe metabolism of Diphenhydramine can be decreased when combined with Delavirdine.Approved
DisopyramideThe metabolism of Disopyramide can be decreased when combined with Delavirdine.Approved
DisulfiramThe metabolism of Disulfiram can be decreased when combined with Delavirdine.Approved
DocetaxelThe metabolism of Docetaxel can be decreased when combined with Delavirdine.Approved, Investigational
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Delavirdine.Approved
DolasetronThe metabolism of Dolasetron can be decreased when combined with Delavirdine.Approved
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Delavirdine.Approved, Investigational, Vet Approved
DonepezilThe metabolism of Donepezil can be decreased when combined with Delavirdine.Approved
DopamineThe metabolism of Dopamine can be decreased when combined with Delavirdine.Approved
DorzolamideThe metabolism of Dorzolamide can be decreased when combined with Delavirdine.Approved
DoxazosinThe metabolism of Doxazosin can be decreased when combined with Delavirdine.Approved
DoxepinThe serum concentration of Delavirdine can be decreased when it is combined with Doxepin.Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Delavirdine.Approved, Investigational
DoxorubicinThe metabolism of Doxorubicin can be decreased when combined with Delavirdine.Approved, Investigational
DoxycyclineThe metabolism of Delavirdine can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Delavirdine.Approved, Illicit
DronedaroneThe metabolism of Dronedarone can be decreased when combined with Delavirdine.Approved
DuloxetineThe serum concentration of Duloxetine can be increased when it is combined with Delavirdine.Approved
DutasterideThe metabolism of Dutasteride can be decreased when combined with Delavirdine.Approved, Investigational
EcabetThe serum concentration of Delavirdine can be decreased when it is combined with Ecabet.Approved, Investigational
EdoxabanThe serum concentration of Delavirdine can be decreased when it is combined with Edoxaban.Approved
EfavirenzThe serum concentration of Efavirenz can be increased when it is combined with Delavirdine.Approved, Investigational
ElafinThe serum concentration of Delavirdine can be decreased when it is combined with Elafin.Investigational
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Delavirdine.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Delavirdine.Approved
ElvitegravirThe metabolism of Elvitegravir can be decreased when combined with Delavirdine.Approved
EnalaprilThe serum concentration of Delavirdine can be decreased when it is combined with Enalapril.Approved, Vet Approved
EnalaprilatThe serum concentration of Delavirdine can be decreased when it is combined with Enalaprilat.Approved
EnalkirenThe serum concentration of Delavirdine can be decreased when it is combined with Enalkiren.Experimental
EncainideThe metabolism of Encainide can be decreased when combined with Delavirdine.Approved, Withdrawn
EnclomipheneThe metabolism of Enclomiphene can be decreased when combined with Delavirdine.Investigational
EnfuvirtideThe metabolism of Enfuvirtide can be decreased when combined with Delavirdine.Approved, Investigational
EnzalutamideThe serum concentration of Delavirdine can be decreased when it is combined with Enzalutamide.Approved
EpinastineThe serum concentration of Delavirdine can be decreased when it is combined with Epinastine.Approved, Investigational
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Delavirdine.Approved
EpoprostenolThe metabolism of Epoprostenol can be decreased when combined with Delavirdine.Approved
ErgocalciferolThe metabolism of Ergocalciferol can be decreased when combined with Delavirdine.Approved, Nutraceutical
Ergoloid mesylateThe metabolism of Ergoloid mesylate can be decreased when combined with Delavirdine.Approved
ErgonovineThe metabolism of Ergonovine can be decreased when combined with Delavirdine.Approved
ErgotamineThe metabolism of Ergotamine can be decreased when combined with Delavirdine.Approved
ErlotinibThe metabolism of Erlotinib can be decreased when combined with Delavirdine.Approved, Investigational
ErythromycinThe metabolism of Delavirdine can be decreased when combined with Erythromycin.Approved, Vet Approved
EscitalopramThe metabolism of Escitalopram can be decreased when combined with Delavirdine.Approved, Investigational
Eslicarbazepine acetateThe serum concentration of Delavirdine can be decreased when it is combined with Eslicarbazepine acetate.Approved
EsmirtazapineThe metabolism of Esmirtazapine can be decreased when combined with Delavirdine.Investigational
EsomeprazoleThe serum concentration of Delavirdine can be decreased when it is combined with Esomeprazole.Approved, Investigational
EstazolamThe metabolism of Estazolam can be decreased when combined with Delavirdine.Approved, Illicit
EstradiolThe metabolism of Estradiol can be decreased when combined with Delavirdine.Approved, Investigational, Vet Approved
Estradiol valerate/DienogestThe metabolism of Estradiol valerate/Dienogest can be decreased when combined with Delavirdine.Approved
EstramustineThe metabolism of Estramustine can be decreased when combined with Delavirdine.Approved
EstroneThe metabolism of Estrone can be decreased when combined with Delavirdine.Approved
Estrone sulfateThe metabolism of Estrone sulfate can be decreased when combined with Delavirdine.Approved
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Delavirdine.Approved
EthanolThe metabolism of Ethanol can be decreased when combined with Delavirdine.Approved
Ethinyl EstradiolThe metabolism of Ethinyl Estradiol can be decreased when combined with Delavirdine.Approved
EthosuximideThe metabolism of Ethosuximide can be decreased when combined with Delavirdine.Approved
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Delavirdine.Approved, Illicit
EtodolacThe metabolism of Etodolac can be decreased when combined with Delavirdine.Approved, Investigational, Vet Approved
EtonogestrelThe metabolism of Etonogestrel can be decreased when combined with Delavirdine.Approved, Investigational
EtoposideThe metabolism of Etoposide can be decreased when combined with Delavirdine.Approved
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Delavirdine.Approved, Investigational
EtravirineThe serum concentration of Etravirine can be decreased when it is combined with Delavirdine.Approved
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Delavirdine.Approved
ExemestaneThe metabolism of Exemestane can be decreased when combined with Delavirdine.Approved, Investigational
FamciclovirThe metabolism of Famciclovir can be decreased when combined with Delavirdine.Approved
FamotidineThe serum concentration of Delavirdine can be decreased when it is combined with Famotidine.Approved
FelbamateThe metabolism of Felbamate can be decreased when combined with Delavirdine.Approved
FelodipineThe metabolism of Felodipine can be decreased when combined with Delavirdine.Approved, Investigational
FenofibrateThe metabolism of Fenofibrate can be decreased when combined with Delavirdine.Approved
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Delavirdine.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Delavirdine.Approved
FinasterideThe metabolism of Finasteride can be decreased when combined with Delavirdine.Approved
FingolimodThe metabolism of Fingolimod can be decreased when combined with Delavirdine.Approved, Investigational
FlecainideThe metabolism of Flecainide can be decreased when combined with Delavirdine.Approved, Withdrawn
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Delavirdine.Approved
FluconazoleThe metabolism of Delavirdine can be decreased when combined with Fluconazole.Approved
FlunarizineThe metabolism of Flunarizine can be decreased when combined with Delavirdine.Approved
FlunisolideThe metabolism of Flunisolide can be decreased when combined with Delavirdine.Approved, Investigational
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Delavirdine.Approved, Illicit
FluorometholoneThe metabolism of Fluorometholone can be decreased when combined with Delavirdine.Approved
FluoxetineThe metabolism of Fluoxetine can be decreased when combined with Delavirdine.Approved, Vet Approved
FluphenazineThe metabolism of Fluphenazine can be decreased when combined with Delavirdine.Approved
FlurazepamThe metabolism of Flurazepam can be decreased when combined with Delavirdine.Approved, Illicit
FlurbiprofenThe metabolism of Flurbiprofen can be decreased when combined with Delavirdine.Approved, Investigational
FlutamideThe metabolism of Flutamide can be decreased when combined with Delavirdine.Approved
Fluticasone furoateThe metabolism of Fluticasone furoate can be decreased when combined with Delavirdine.Approved
Fluticasone PropionateThe metabolism of Fluticasone Propionate can be decreased when combined with Delavirdine.Approved
FluvastatinThe metabolism of Fluvastatin can be decreased when combined with Delavirdine.Approved
FluvoxamineThe metabolism of Fluvoxamine can be decreased when combined with Delavirdine.Approved, Investigational
FormoterolThe metabolism of Formoterol can be decreased when combined with Delavirdine.Approved, Investigational
FosamprenavirThe serum concentration of Delavirdine can be decreased when it is combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Delavirdine can be increased when it is combined with Fosaprepitant.Approved
FosinoprilThe serum concentration of Delavirdine can be decreased when it is combined with Fosinopril.Approved
FosphenytoinThe serum concentration of Delavirdine can be decreased when it is combined with Fosphenytoin.Approved
FulvestrantThe metabolism of Fulvestrant can be decreased when combined with Delavirdine.Approved, Investigational
Fusidic AcidThe serum concentration of Delavirdine can be increased when it is combined with Fusidic Acid.Approved
GabexateThe serum concentration of Delavirdine can be decreased when it is combined with Gabexate.Investigational
GalantamineThe metabolism of Galantamine can be decreased when combined with Delavirdine.Approved
GavestinelThe metabolism of Gavestinel can be decreased when combined with Delavirdine.Investigational
GefitinibThe metabolism of Gefitinib can be decreased when combined with Delavirdine.Approved, Investigational
GeldanamycinThe serum concentration of Delavirdine can be decreased when it is combined with Geldanamycin.Experimental
GemfibrozilThe metabolism of Gemfibrozil can be decreased when combined with Delavirdine.Approved
GliclazideThe metabolism of Gliclazide can be decreased when combined with Delavirdine.Approved
GlimepirideThe metabolism of Glimepiride can be decreased when combined with Delavirdine.Approved
GlipizideThe metabolism of Glipizide can be decreased when combined with Delavirdine.Approved
GlucosamineThe metabolism of Glucosamine can be decreased when combined with Delavirdine.Approved
GlyburideThe metabolism of Glyburide can be decreased when combined with Delavirdine.Approved
GM6001The serum concentration of Delavirdine can be decreased when it is combined with GM6001.Experimental
GranisetronThe metabolism of Granisetron can be decreased when combined with Delavirdine.Approved, Investigational
GrepafloxacinThe metabolism of Grepafloxacin can be decreased when combined with Delavirdine.Withdrawn
GuanfacineThe metabolism of Guanfacine can be decreased when combined with Delavirdine.Approved, Investigational
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Delavirdine.Approved
HaloperidolThe metabolism of Haloperidol can be decreased when combined with Delavirdine.Approved
HalothaneThe metabolism of Halothane can be decreased when combined with Delavirdine.Approved, Vet Approved
HexobarbitalThe metabolism of Hexobarbital can be decreased when combined with Delavirdine.Approved
HirulogThe serum concentration of Delavirdine can be decreased when it is combined with Hirulog.Experimental
Histamine PhosphateThe metabolism of Histamine Phosphate can be decreased when combined with Delavirdine.Approved
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Delavirdine.Approved, Illicit
HydrocortisoneThe metabolism of Hydrocortisone can be decreased when combined with Delavirdine.Approved, Vet Approved
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Delavirdine.Approved, Illicit
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be decreased when combined with Delavirdine.Approved
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Delavirdine.Approved
IbuprofenThe metabolism of Ibuprofen can be decreased when combined with Delavirdine.Approved
IdarubicinThe metabolism of Idarubicin can be decreased when combined with Delavirdine.Approved
IdelalisibThe serum concentration of Delavirdine can be increased when it is combined with Idelalisib.Approved
idraparinuxThe serum concentration of Delavirdine can be decreased when it is combined with idraparinux.Investigational
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Delavirdine resulting in a loss in efficacy.Approved
IloperidoneThe serum concentration of the active metabolites of Iloperidone can be increased when Iloperidone is used in combination with Delavirdine.Approved
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Delavirdine.Approved
ImidaprilThe serum concentration of Delavirdine can be decreased when it is combined with Imidapril.Investigational
ImipramineThe metabolism of Imipramine can be decreased when combined with Delavirdine.Approved
ImiquimodThe metabolism of Imiquimod can be decreased when combined with Delavirdine.Approved, Investigational
IndacaterolThe metabolism of Indacaterol can be decreased when combined with Delavirdine.Approved
IndapamideThe metabolism of Indapamide can be decreased when combined with Delavirdine.Approved
IndinavirThe serum concentration of Delavirdine can be decreased when it is combined with Indinavir.Approved
indisulamThe metabolism of indisulam can be decreased when combined with Delavirdine.Investigational
IndomethacinThe metabolism of Indomethacin can be decreased when combined with Delavirdine.Approved, Investigational
Ipratropium bromideThe metabolism of Ipratropium bromide can be decreased when combined with Delavirdine.Approved
IrbesartanThe metabolism of Irbesartan can be decreased when combined with Delavirdine.Approved, Investigational
IrinotecanThe metabolism of Irinotecan can be decreased when combined with Delavirdine.Approved, Investigational
IsavuconazoniumThe metabolism of Delavirdine can be decreased when combined with Isavuconazonium.Approved, Investigational
IsoflurophateThe serum concentration of Delavirdine can be decreased when it is combined with Isoflurophate.Approved, Withdrawn
IsoniazidThe metabolism of Delavirdine can be decreased when combined with Isoniazid.Approved
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be decreased when combined with Delavirdine.Approved
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be decreased when combined with Delavirdine.Approved
IsradipineThe metabolism of Delavirdine can be decreased when combined with Isradipine.Approved
ItraconazoleThe metabolism of Delavirdine can be decreased when combined with Itraconazole.Approved, Investigational
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Delavirdine.Approved
IvacaftorThe serum concentration of Ivacaftor can be increased when it is combined with Delavirdine.Approved
IvermectinThe metabolism of Ivermectin can be decreased when combined with Delavirdine.Approved, Vet Approved
IxabepiloneThe metabolism of Ixabepilone can be decreased when combined with Delavirdine.Approved, Investigational
IxazomibThe serum concentration of Delavirdine can be decreased when it is combined with Ixazomib.Approved
KetamineThe metabolism of Ketamine can be decreased when combined with Delavirdine.Approved, Vet Approved
KetazolamThe metabolism of Ketazolam can be decreased when combined with Delavirdine.Approved
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Delavirdine.Approved
KetoconazoleThe metabolism of Delavirdine can be decreased when combined with Ketoconazole.Approved, Investigational
KetoprofenThe metabolism of Ketoprofen can be decreased when combined with Delavirdine.Approved, Vet Approved
LabetalolThe metabolism of Labetalol can be decreased when combined with Delavirdine.Approved
LacosamideThe serum concentration of Lacosamide can be increased when it is combined with Delavirdine.Approved
LansoprazoleThe serum concentration of Delavirdine can be decreased when it is combined with Lansoprazole.Approved, Investigational
LapatinibThe metabolism of Lapatinib can be decreased when combined with Delavirdine.Approved, Investigational
LaquinimodThe metabolism of Laquinimod can be decreased when combined with Delavirdine.Investigational
LeflunomideThe metabolism of Leflunomide can be decreased when combined with Delavirdine.Approved, Investigational
LenvatinibThe metabolism of Lenvatinib can be decreased when combined with Delavirdine.Approved
LepirudinThe serum concentration of Delavirdine can be decreased when it is combined with Lepirudin.Approved
LercanidipineThe metabolism of Lercanidipine can be decreased when combined with Delavirdine.Approved, Investigational
LesinuradThe metabolism of Lesinurad can be decreased when combined with Delavirdine.Approved
LetrozoleThe metabolism of Letrozole can be decreased when combined with Delavirdine.Approved, Investigational
LevobupivacaineThe metabolism of Levobupivacaine can be decreased when combined with Delavirdine.Approved
LevocetirizineThe metabolism of Levocetirizine can be decreased when combined with Delavirdine.Approved
LevodopaThe metabolism of Levodopa can be decreased when combined with Delavirdine.Approved
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be decreased when combined with Delavirdine.Approved
LevomilnacipranThe metabolism of Levomilnacipran can be decreased when combined with Delavirdine.Approved
LevonorgestrelThe metabolism of Levonorgestrel can be decreased when combined with Delavirdine.Approved, Investigational
LevothyroxineThe metabolism of Levothyroxine can be decreased when combined with Delavirdine.Approved
LicofeloneThe metabolism of Licofelone can be decreased when combined with Delavirdine.Investigational
LidocaineThe metabolism of Lidocaine can be decreased when combined with Delavirdine.Approved, Vet Approved
LinagliptinThe serum concentration of Delavirdine can be decreased when it is combined with Linagliptin.Approved
LisinoprilThe serum concentration of Delavirdine can be decreased when it is combined with Lisinopril.Approved, Investigational
LisurideThe metabolism of Lisuride can be decreased when combined with Delavirdine.Approved
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Delavirdine.Approved
LomustineThe metabolism of Lomustine can be decreased when combined with Delavirdine.Approved
LoperamideThe metabolism of Loperamide can be decreased when combined with Delavirdine.Approved
LopinavirThe serum concentration of Delavirdine can be decreased when it is combined with Lopinavir.Approved
LoratadineThe metabolism of Loratadine can be decreased when combined with Delavirdine.Approved
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Delavirdine.Approved
LornoxicamThe metabolism of Lornoxicam can be decreased when combined with Delavirdine.Approved
LosartanThe metabolism of Losartan can be decreased when combined with Delavirdine.Approved
LovastatinThe metabolism of Delavirdine can be decreased when combined with Lovastatin.Approved, Investigational
LuliconazoleThe serum concentration of Delavirdine can be increased when it is combined with Luliconazole.Approved
LumacaftorThe metabolism of Delavirdine can be increased when combined with Lumacaftor.Approved
LumefantrineThe metabolism of Lumefantrine can be decreased when combined with Delavirdine.Approved
LumiracoxibThe metabolism of Lumiracoxib can be decreased when combined with Delavirdine.Approved, Investigational
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Delavirdine.Approved
MacitentanThe metabolism of Macitentan can be decreased when combined with Delavirdine.Approved
MagaldrateThe serum concentration of Delavirdine can be decreased when it is combined with Magaldrate.Withdrawn
Magnesium carbonateThe serum concentration of Delavirdine can be decreased when it is combined with Magnesium carbonate.Approved
Magnesium hydroxideThe serum concentration of Delavirdine can be decreased when it is combined with Magnesium hydroxide.Approved
Magnesium oxideThe serum concentration of Delavirdine can be decreased when it is combined with Magnesium oxide.Approved
Magnesium TrisilicateThe serum concentration of Delavirdine can be decreased when it is combined with Magnesium Trisilicate.Approved
MaprotilineThe metabolism of Maprotiline can be decreased when combined with Delavirdine.Approved
MaravirocThe metabolism of Maraviroc can be decreased when combined with Delavirdine.Approved, Investigational
MebendazoleThe metabolism of Mebendazole can be decreased when combined with Delavirdine.Approved, Vet Approved
Medroxyprogesterone acetateThe metabolism of Medroxyprogesterone acetate can be decreased when combined with Delavirdine.Approved, Investigational
Mefenamic acidThe metabolism of Mefenamic acid can be decreased when combined with Delavirdine.Approved
MefloquineThe metabolism of Mefloquine can be decreased when combined with Delavirdine.Approved
MelatoninThe metabolism of Melatonin can be decreased when combined with Delavirdine.Approved, Nutraceutical, Vet Approved
MeloxicamThe metabolism of Meloxicam can be decreased when combined with Delavirdine.Approved, Vet Approved
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Delavirdine.Investigational, Withdrawn
MeprobamateThe metabolism of Meprobamate can be decreased when combined with Delavirdine.Approved, Illicit
MequitazineThe serum concentration of Mequitazine can be increased when it is combined with Delavirdine.Approved
MesoridazineThe metabolism of Mesoridazine can be decreased when combined with Delavirdine.Approved
MestranolThe metabolism of Mestranol can be decreased when combined with Delavirdine.Approved
MethadoneThe metabolism of Methadone can be increased when combined with Delavirdine.Approved
MethamphetamineThe metabolism of Methamphetamine can be decreased when combined with Delavirdine.Approved, Illicit
MethanthelineThe serum concentration of Delavirdine can be decreased when it is combined with Methantheline.Approved
MethaqualoneThe metabolism of Methaqualone can be decreased when combined with Delavirdine.Illicit, Withdrawn
MethotrimeprazineThe metabolism of Methotrimeprazine can be decreased when combined with Delavirdine.Approved
MethoxsalenThe metabolism of Methoxsalen can be decreased when combined with Delavirdine.Approved
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Delavirdine.Approved, Vet Approved
MethsuximideThe metabolism of Methsuximide can be decreased when combined with Delavirdine.Approved
MethylphenidateThe metabolism of Methylphenidate can be decreased when combined with Delavirdine.Approved, Investigational
MethylphenobarbitalThe metabolism of Methylphenobarbital can be decreased when combined with Delavirdine.Approved
MethylprednisoloneThe metabolism of Methylprednisolone can be decreased when combined with Delavirdine.Approved, Vet Approved
MethyltestosteroneThe metabolism of Methyltestosterone can be decreased when combined with Delavirdine.Approved
MethyprylonThe metabolism of Methyprylon can be decreased when combined with Delavirdine.Approved, Illicit, Withdrawn
MetiamideThe serum concentration of Delavirdine can be decreased when it is combined with Metiamide.Experimental
MetoclopramideThe metabolism of Metoclopramide can be decreased when combined with Delavirdine.Approved, Investigational
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Delavirdine.Approved, Investigational
MetronidazoleThe metabolism of Metronidazole can be decreased when combined with Delavirdine.Approved
MexiletineThe metabolism of Mexiletine can be decreased when combined with Delavirdine.Approved
MianserinThe metabolism of Mianserin can be decreased when combined with Delavirdine.Approved
MibefradilThe metabolism of Mibefradil can be decreased when combined with Delavirdine.Withdrawn
MiconazoleThe metabolism of Miconazole can be decreased when combined with Delavirdine.Approved, Investigational, Vet Approved
MidazolamThe metabolism of Midazolam can be decreased when combined with Delavirdine.Approved, Illicit
MifepristoneThe serum concentration of Delavirdine can be increased when it is combined with Mifepristone.Approved, Investigational
MinaprineThe metabolism of Minaprine can be decreased when combined with Delavirdine.Approved
MirabegronThe metabolism of Mirabegron can be decreased when combined with Delavirdine.Approved
MirtazapineThe metabolism of Mirtazapine can be decreased when combined with Delavirdine.Approved
MitotaneThe serum concentration of Delavirdine can be decreased when it is combined with Mitotane.Approved
MoclobemideThe metabolism of Moclobemide can be decreased when combined with Delavirdine.Approved
ModafinilThe serum concentration of Delavirdine can be decreased when it is combined with Modafinil.Approved, Investigational
MoexiprilThe serum concentration of Delavirdine can be decreased when it is combined with Moexipril.Approved
MontelukastThe metabolism of Montelukast can be decreased when combined with Delavirdine.Approved
MorphineThe metabolism of Morphine can be decreased when combined with Delavirdine.Approved, Investigational
Mycophenolate mofetilThe metabolism of Mycophenolate mofetil can be decreased when combined with Delavirdine.Approved, Investigational
N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-ProlineThe serum concentration of Delavirdine can be decreased when it is combined with N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-Proline.Experimental
NafamostatThe serum concentration of Delavirdine can be decreased when it is combined with Nafamostat.Investigational
NafcillinThe serum concentration of Delavirdine can be decreased when it is combined with Nafcillin.Approved
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Delavirdine.Approved
NaloxoneThe metabolism of Naloxone can be decreased when combined with Delavirdine.Approved, Vet Approved
NaproxenThe metabolism of Naproxen can be decreased when combined with Delavirdine.Approved, Vet Approved
NateglinideThe metabolism of Nateglinide can be decreased when combined with Delavirdine.Approved, Investigational
NCX 4016The serum concentration of Delavirdine can be decreased when it is combined with NCX 4016.Investigational
NebivololThe serum concentration of Nebivolol can be increased when it is combined with Delavirdine.Approved, Investigational
NefazodoneThe metabolism of Delavirdine can be decreased when combined with Nefazodone.Approved, Withdrawn
NelfinavirThe serum concentration of Delavirdine can be decreased when it is combined with Nelfinavir.Approved
NetupitantThe serum concentration of Delavirdine can be increased when it is combined with Netupitant.Approved
NevirapineThe metabolism of Delavirdine can be increased when combined with Nevirapine.Approved
NicardipineThe metabolism of Nicardipine can be decreased when combined with Delavirdine.Approved
NicergolineThe metabolism of Nicergoline can be decreased when combined with Delavirdine.Approved
NiclosamideThe metabolism of Niclosamide can be decreased when combined with Delavirdine.Approved, Vet Approved
NicotineThe metabolism of Nicotine can be decreased when combined with Delavirdine.Approved
NifedipineThe metabolism of Nifedipine can be decreased when combined with Delavirdine.Approved
NilotinibThe metabolism of Nilotinib can be decreased when combined with Delavirdine.Approved, Investigational
NilutamideThe metabolism of Nilutamide can be decreased when combined with Delavirdine.Approved
NilvadipineThe metabolism of Nilvadipine can be decreased when combined with Delavirdine.Approved
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Delavirdine.Approved
NisoldipineThe metabolism of Nisoldipine can be decreased when combined with Delavirdine.Approved
NitrazepamThe metabolism of Nitrazepam can be decreased when combined with Delavirdine.Approved
NitrendipineThe metabolism of Nitrendipine can be decreased when combined with Delavirdine.Approved
NitroaspirinThe serum concentration of Delavirdine can be decreased when it is combined with Nitroaspirin.Investigational
NitrofuralThe metabolism of Nitrofural can be decreased when combined with Delavirdine.Approved, Vet Approved
NizatidineThe serum concentration of Delavirdine can be decreased when it is combined with Nizatidine.Approved
NorethisteroneThe metabolism of Norethisterone can be decreased when combined with Delavirdine.Approved
NorgestrelThe metabolism of Norgestrel can be decreased when combined with Delavirdine.Approved
NortriptylineThe metabolism of Nortriptyline can be decreased when combined with Delavirdine.Approved
OlanzapineThe serum concentration of Delavirdine can be decreased when it is combined with Olanzapine.Approved, Investigational
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Delavirdine.Approved
OlodaterolThe metabolism of Olodaterol can be decreased when combined with Delavirdine.Approved
OlopatadineThe metabolism of Olopatadine can be decreased when combined with Delavirdine.Approved
OmapatrilatThe serum concentration of Delavirdine can be decreased when it is combined with Omapatrilat.Investigational
OmeprazoleThe serum concentration of Delavirdine can be decreased when it is combined with Omeprazole.Approved, Investigational, Vet Approved
OndansetronThe metabolism of Ondansetron can be decreased when combined with Delavirdine.Approved
OrphenadrineThe metabolism of Orphenadrine can be decreased when combined with Delavirdine.Approved
OsimertinibThe serum concentration of Delavirdine can be increased when it is combined with Osimertinib.Approved
OspemifeneThe serum concentration of Ospemifene can be increased when it is combined with Delavirdine.Approved
OtamixabanThe serum concentration of Delavirdine can be decreased when it is combined with Otamixaban.Investigational
OxaprozinThe metabolism of Oxaprozin can be decreased when combined with Delavirdine.Approved
OxazepamThe metabolism of Oxazepam can be decreased when combined with Delavirdine.Approved
OxiconazoleThe metabolism of Oxiconazole can be decreased when combined with Delavirdine.Approved
OxybutyninThe metabolism of Oxybutynin can be decreased when combined with Delavirdine.Approved, Investigational
OxycodoneThe risk or severity of adverse effects can be increased when Delavirdine is combined with Oxycodone.Approved, Illicit, Investigational
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Delavirdine.Approved, Investigational, Vet Approved
PaclitaxelThe metabolism of Paclitaxel can be decreased when combined with Delavirdine.Approved, Vet Approved
PalbociclibThe serum concentration of Delavirdine can be increased when it is combined with Palbociclib.Approved
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Delavirdine.Approved, Investigational
PanobinostatThe serum concentration of Delavirdine can be increased when it is combined with Panobinostat.Approved, Investigational
PantoprazoleThe serum concentration of Delavirdine can be decreased when it is combined with Pantoprazole.Approved
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Delavirdine.Approved
ParamethasoneThe metabolism of Paramethasone can be decreased when combined with Delavirdine.Approved
ParecoxibThe serum concentration of Parecoxib can be increased when it is combined with Delavirdine.Approved
ParicalcitolThe metabolism of Paricalcitol can be decreased when combined with Delavirdine.Approved, Investigational
ParitaprevirThe metabolism of Paritaprevir can be decreased when combined with Delavirdine.Approved
ParoxetineThe metabolism of Paroxetine can be decreased when combined with Delavirdine.Approved, Investigational
PazopanibThe metabolism of Pazopanib can be decreased when combined with Delavirdine.Approved
Peginterferon alfa-2bThe serum concentration of Delavirdine can be decreased when it is combined with Peginterferon alfa-2b.Approved
PentamidineThe metabolism of Pentamidine can be decreased when combined with Delavirdine.Approved
PentobarbitalThe metabolism of Delavirdine can be increased when combined with Pentobarbital.Approved, Vet Approved
PerampanelThe metabolism of Perampanel can be decreased when combined with Delavirdine.Approved
PergolideThe metabolism of Pergolide can be decreased when combined with Delavirdine.Approved, Vet Approved, Withdrawn
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Delavirdine.Approved
PerindoprilThe serum concentration of Delavirdine can be decreased when it is combined with Perindopril.Approved
PermethrinThe metabolism of Permethrin can be decreased when combined with Delavirdine.Approved, Investigational
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Delavirdine.Approved
PethidineThe metabolism of Pethidine can be decreased when combined with Delavirdine.Approved
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Delavirdine.Withdrawn
PhenforminThe metabolism of Phenformin can be decreased when combined with Delavirdine.Approved, Withdrawn
PhenobarbitalThe metabolism of Delavirdine can be increased when combined with Phenobarbital.Approved
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be decreased when combined with Delavirdine.Approved
PhenprocoumonThe metabolism of Phenprocoumon can be decreased when combined with Delavirdine.Approved
PhenylbutazoneThe metabolism of Phenylbutazone can be decreased when combined with Delavirdine.Approved, Vet Approved
PhenytoinThe serum concentration of Delavirdine can be decreased when it is combined with Phenytoin.Approved, Vet Approved
PhosphoramidonThe serum concentration of Delavirdine can be decreased when it is combined with Phosphoramidon.Experimental
PilocarpineThe metabolism of Pilocarpine can be decreased when combined with Delavirdine.Approved
PimecrolimusThe metabolism of Pimecrolimus can be decreased when combined with Delavirdine.Approved, Investigational
PimozideThe serum concentration of Pimozide can be increased when it is combined with Delavirdine.Approved
PinacidilThe metabolism of Pinacidil can be decreased when combined with Delavirdine.Withdrawn
PindololThe metabolism of Pindolol can be decreased when combined with Delavirdine.Approved
PioglitazoneThe metabolism of Pioglitazone can be decreased when combined with Delavirdine.Approved, Investigational
PiperazineThe metabolism of Piperazine can be decreased when combined with Delavirdine.Approved, Vet Approved
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Delavirdine.Approved
PiroxicamThe metabolism of Piroxicam can be decreased when combined with Delavirdine.Approved, Investigational
PitavastatinThe metabolism of Pitavastatin can be decreased when combined with Delavirdine.Approved
PodofiloxThe metabolism of Podofilox can be decreased when combined with Delavirdine.Approved
PomalidomideThe metabolism of Pomalidomide can be decreased when combined with Delavirdine.Approved
PonatinibThe metabolism of Ponatinib can be decreased when combined with Delavirdine.Approved
PosaconazoleThe metabolism of Delavirdine can be decreased when combined with Posaconazole.Approved, Investigational, Vet Approved
PrasteroneThe metabolism of Prasterone can be decreased when combined with Delavirdine.Approved, Nutraceutical
PrasugrelThe metabolism of Prasugrel can be decreased when combined with Delavirdine.Approved
PravastatinThe metabolism of Pravastatin can be decreased when combined with Delavirdine.Approved
PrazepamThe metabolism of Prazepam can be decreased when combined with Delavirdine.Approved, Illicit
PraziquantelThe metabolism of Praziquantel can be decreased when combined with Delavirdine.Approved, Vet Approved
PrednisoloneThe metabolism of Prednisolone can be decreased when combined with Delavirdine.Approved, Vet Approved
PrednisoneThe metabolism of Prednisone can be decreased when combined with Delavirdine.Approved, Vet Approved
PrimaquineThe metabolism of Primaquine can be decreased when combined with Delavirdine.Approved
PrimidoneThe metabolism of Delavirdine can be increased when combined with Primidone.Approved, Vet Approved
PrinomastatThe serum concentration of Delavirdine can be decreased when it is combined with Prinomastat.Investigational
ProcainamideThe metabolism of Procainamide can be decreased when combined with Delavirdine.Approved
ProchlorperazineThe metabolism of Prochlorperazine can be decreased when combined with Delavirdine.Approved, Vet Approved
ProgesteroneThe metabolism of Progesterone can be decreased when combined with Delavirdine.Approved, Vet Approved
ProguanilThe metabolism of Proguanil can be decreased when combined with Delavirdine.Approved
PromazineThe metabolism of Promazine can be decreased when combined with Delavirdine.Approved, Vet Approved
PromethazineThe metabolism of Promethazine can be decreased when combined with Delavirdine.Approved
PropafenoneThe serum concentration of Propafenone can be increased when it is combined with Delavirdine.Approved
PropofolThe metabolism of Propofol can be decreased when combined with Delavirdine.Approved, Investigational, Vet Approved
PropranololThe metabolism of Propranolol can be decreased when combined with Delavirdine.Approved, Investigational
ProtriptylineThe metabolism of Protriptyline can be decreased when combined with Delavirdine.Approved
PseudoephedrineThe metabolism of Pseudoephedrine can be decreased when combined with Delavirdine.Approved
PyrazinamideThe metabolism of Pyrazinamide can be decreased when combined with Delavirdine.Approved
QuazepamThe metabolism of Quazepam can be decreased when combined with Delavirdine.Approved, Illicit
QuetiapineThe metabolism of Quetiapine can be decreased when combined with Delavirdine.Approved
QuinacrineThe metabolism of Quinacrine can be decreased when combined with Delavirdine.Approved
QuinaprilThe serum concentration of Delavirdine can be decreased when it is combined with Quinapril.Approved, Investigational
QuinidineThe metabolism of Delavirdine can be decreased when combined with Quinidine.Approved
QuinineThe metabolism of Quinine can be decreased when combined with Delavirdine.Approved
RabeprazoleThe serum concentration of Delavirdine can be decreased when it is combined with Rabeprazole.Approved, Investigational
RacecadotrilThe serum concentration of Delavirdine can be decreased when it is combined with Racecadotril.Investigational
RaloxifeneThe metabolism of Raloxifene can be decreased when combined with Delavirdine.Approved, Investigational
RamelteonThe serum concentration of Ramelteon can be increased when it is combined with Delavirdine.Approved, Investigational
RamiprilThe serum concentration of Delavirdine can be decreased when it is combined with Ramipril.Approved
RanitidineThe serum concentration of Delavirdine can be decreased when it is combined with Ranitidine.Approved
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Delavirdine.Approved, Investigational
ReboxetineThe metabolism of Reboxetine can be decreased when combined with Delavirdine.Approved, Investigational
RegorafenibThe metabolism of Regorafenib can be decreased when combined with Delavirdine.Approved
RemikirenThe serum concentration of Delavirdine can be decreased when it is combined with Remikiren.Approved
RemoxiprideThe metabolism of Remoxipride can be decreased when combined with Delavirdine.Approved, Withdrawn
RepaglinideThe metabolism of Repaglinide can be decreased when combined with Delavirdine.Approved, Investigational
repinotanThe metabolism of repinotan can be decreased when combined with Delavirdine.Investigational
RetapamulinThe metabolism of Retapamulin can be decreased when combined with Delavirdine.Approved
RifabutinThe metabolism of Delavirdine can be increased when combined with Rifabutin.Approved
RifampicinThe metabolism of Delavirdine can be increased when combined with Rifampicin.Approved
RifapentineThe metabolism of Delavirdine can be increased when combined with Rifapentine.Approved
RilpivirineThe serum concentration of Rilpivirine can be increased when it is combined with Delavirdine.Approved
RimonabantThe metabolism of Rimonabant can be decreased when combined with Delavirdine.Approved, Investigational
RiociguatThe metabolism of Riociguat can be decreased when combined with Delavirdine.Approved
RisperidoneThe metabolism of Risperidone can be decreased when combined with Delavirdine.Approved, Investigational
RitonavirThe serum concentration of Delavirdine can be decreased when it is combined with Ritonavir.Approved, Investigational
RivaroxabanThe serum concentration of Delavirdine can be decreased when it is combined with Rivaroxaban.Approved
RofecoxibThe metabolism of Rofecoxib can be decreased when combined with Delavirdine.Investigational, Withdrawn
RolapitantThe metabolism of Rolapitant can be decreased when combined with Delavirdine.Approved
RomidepsinThe metabolism of Romidepsin can be decreased when combined with Delavirdine.Approved, Investigational
RopiniroleThe metabolism of Ropinirole can be decreased when combined with Delavirdine.Approved, Investigational
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Delavirdine.Approved
RosiglitazoneThe metabolism of Rosiglitazone can be decreased when combined with Delavirdine.Approved, Investigational
RosuvastatinThe metabolism of Rosuvastatin can be decreased when combined with Delavirdine.Approved
RotigotineThe metabolism of Rotigotine can be decreased when combined with Delavirdine.Approved
Roxatidine acetateThe serum concentration of Delavirdine can be decreased when it is combined with Roxatidine acetate.Approved
RoxithromycinThe metabolism of Roxithromycin can be decreased when combined with Delavirdine.Approved, Withdrawn
RuxolitinibThe metabolism of Ruxolitinib can be decreased when combined with Delavirdine.Approved
Salicylic acidThe metabolism of Salicylic acid can be decreased when combined with Delavirdine.Approved, Vet Approved
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Delavirdine.Approved
SaquinavirThe serum concentration of Delavirdine can be decreased when it is combined with Saquinavir.Approved, Investigational
SaxagliptinThe serum concentration of Delavirdine can be decreased when it is combined with Saxagliptin.Approved
SelegilineThe metabolism of Selegiline can be decreased when combined with Delavirdine.Approved, Investigational, Vet Approved
SelexipagThe metabolism of Selexipag can be decreased when combined with Delavirdine.Approved
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Delavirdine.Approved, Investigational
SertindoleThe metabolism of Sertindole can be decreased when combined with Delavirdine.Approved, Withdrawn
SertralineThe metabolism of Sertraline can be decreased when combined with Delavirdine.Approved
SevofluraneThe metabolism of Sevoflurane can be decreased when combined with Delavirdine.Approved, Vet Approved
SibutramineThe metabolism of Sibutramine can be decreased when combined with Delavirdine.Approved, Illicit, Investigational, Withdrawn
SildenafilThe metabolism of Sildenafil can be decreased when combined with Delavirdine.Approved, Investigational
SilodosinThe metabolism of Silodosin can be decreased when combined with Delavirdine.Approved
SiltuximabThe serum concentration of Delavirdine can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with Delavirdine.Approved
SimvastatinThe metabolism of Simvastatin can be decreased when combined with Delavirdine.Approved
SirolimusThe metabolism of Sirolimus can be decreased when combined with Delavirdine.Approved, Investigational
SitagliptinThe serum concentration of Delavirdine can be decreased when it is combined with Sitagliptin.Approved, Investigational
SitaxentanThe metabolism of Sitaxentan can be decreased when combined with Delavirdine.Approved, Investigational, Withdrawn
SolifenacinThe metabolism of Solifenacin can be decreased when combined with Delavirdine.Approved
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Delavirdine.Approved, Investigational
SorafenibThe metabolism of Sorafenib can be decreased when combined with Delavirdine.Approved, Investigational
SparteineThe metabolism of Sparteine can be decreased when combined with Delavirdine.Experimental
SpiramycinThe metabolism of Spiramycin can be decreased when combined with Delavirdine.Approved
SpiraprilThe serum concentration of Delavirdine can be decreased when it is combined with Spirapril.Approved
St. John's WortThe serum concentration of Delavirdine can be decreased when it is combined with St. John's Wort.Nutraceutical
StiripentolThe serum concentration of Delavirdine can be increased when it is combined with Stiripentol.Approved
SufentanilThe metabolism of Sufentanil can be decreased when combined with Delavirdine.Approved, Investigational
SulfadiazineThe metabolism of Sulfadiazine can be decreased when combined with Delavirdine.Approved, Vet Approved
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be decreased when combined with Delavirdine.Approved
SulfamoxoleThe metabolism of Sulfamoxole can be decreased when combined with Delavirdine.Approved
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be decreased when combined with Delavirdine.Approved
SulfisoxazoleThe metabolism of Sulfisoxazole can be decreased when combined with Delavirdine.Approved, Vet Approved
SunitinibThe metabolism of Sunitinib can be decreased when combined with Delavirdine.Approved, Investigational
SuprofenThe metabolism of Suprofen can be decreased when combined with Delavirdine.Approved, Withdrawn
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Delavirdine.Approved
Synthetic Conjugated Estrogens, AThe metabolism of Synthetic Conjugated Estrogens, A can be decreased when combined with Delavirdine.Approved
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be decreased when combined with Delavirdine.Approved
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Delavirdine.Approved, Investigational
TadalafilThe metabolism of Tadalafil can be decreased when combined with Delavirdine.Approved, Investigational
TAK-390MRThe serum concentration of Delavirdine can be decreased when it is combined with TAK-390MR.Investigational
TamoxifenThe serum concentration of the active metabolites of Tamoxifen can be reduced when Tamoxifen is used in combination with Delavirdine resulting in a loss in efficacy.Approved
TamsulosinThe serum concentration of Tamsulosin can be increased when it is combined with Delavirdine.Approved, Investigational
TapentadolThe metabolism of Tapentadol can be decreased when combined with Delavirdine.Approved
TasosartanThe metabolism of Tasosartan can be decreased when combined with Delavirdine.Approved
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be decreased when combined with Delavirdine.Experimental
TegaserodThe metabolism of Tegaserod can be decreased when combined with Delavirdine.Investigational, Withdrawn
TelaprevirThe serum concentration of Delavirdine can be decreased when it is combined with Telaprevir.Approved
TelithromycinThe metabolism of Delavirdine can be decreased when combined with Telithromycin.Approved
TemazepamThe metabolism of Temazepam can be decreased when combined with Delavirdine.Approved
TemocaprilThe serum concentration of Delavirdine can be decreased when it is combined with Temocapril.Experimental, Investigational
TemsirolimusThe metabolism of Temsirolimus can be decreased when combined with Delavirdine.Approved
TeniposideThe metabolism of Teniposide can be decreased when combined with Delavirdine.Approved
TenoxicamThe metabolism of Tenoxicam can be decreased when combined with Delavirdine.Approved
TerbinafineThe metabolism of Terbinafine can be decreased when combined with Delavirdine.Approved, Investigational, Vet Approved
TerfenadineDelavirdine may increase the arrhythmogenic activities of Terfenadine.Withdrawn
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Delavirdine.Investigational
TestosteroneThe metabolism of Testosterone can be decreased when combined with Delavirdine.Approved, Investigational
TetrabenazineThe serum concentration of Tetrabenazine can be increased when it is combined with Delavirdine.Approved
TetracyclineThe metabolism of Tetracycline can be decreased when combined with Delavirdine.Approved, Vet Approved
ThalidomideThe metabolism of Thalidomide can be decreased when combined with Delavirdine.Approved, Investigational, Withdrawn
TheophyllineThe metabolism of Theophylline can be decreased when combined with Delavirdine.Approved
ThiamylalThe metabolism of Thiamylal can be decreased when combined with Delavirdine.Approved, Vet Approved
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Delavirdine.Approved
ThiorphanThe serum concentration of Delavirdine can be decreased when it is combined with Thiorphan.Experimental
ThiotepaThe metabolism of Thiotepa can be decreased when combined with Delavirdine.Approved
TiagabineThe metabolism of Tiagabine can be decreased when combined with Delavirdine.Approved
TicagrelorThe metabolism of Ticagrelor can be decreased when combined with Delavirdine.Approved
TiclopidineThe metabolism of Ticlopidine can be decreased when combined with Delavirdine.Approved
TimololThe metabolism of Timolol can be decreased when combined with Delavirdine.Approved
TinidazoleThe metabolism of Tinidazole can be decreased when combined with Delavirdine.Approved, Investigational
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Delavirdine.Approved
TipranavirThe serum concentration of Delavirdine can be decreased when it is combined with Tipranavir.Approved, Investigational
TizanidineThe serum concentration of Tizanidine can be increased when it is combined with Delavirdine.Approved
TocilizumabThe serum concentration of Delavirdine can be decreased when it is combined with Tocilizumab.Approved
TofacitinibThe metabolism of Tofacitinib can be decreased when combined with Delavirdine.Approved, Investigational
TolbutamideThe metabolism of Tolbutamide can be decreased when combined with Delavirdine.Approved
TolterodineThe metabolism of Tolterodine can be decreased when combined with Delavirdine.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Delavirdine.Approved
TorasemideThe metabolism of Torasemide can be decreased when combined with Delavirdine.Approved
ToremifeneThe metabolism of Toremifene can be decreased when combined with Delavirdine.Approved, Investigational
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Delavirdine.Approved, Investigational
TramadolThe therapeutic efficacy of Tramadol can be decreased when used in combination with Delavirdine.Approved, Investigational
TrandolaprilThe serum concentration of Delavirdine can be decreased when it is combined with Trandolapril.Approved
TranylcypromineThe metabolism of Delavirdine can be decreased when combined with Tranylcypromine.Approved
Trastuzumab emtansineThe metabolism of Trastuzumab emtansine can be decreased when combined with Delavirdine.Approved
TrazodoneThe metabolism of Trazodone can be decreased when combined with Delavirdine.Approved, Investigational
TreprostinilThe metabolism of Treprostinil can be decreased when combined with Delavirdine.Approved, Investigational
TretinoinThe metabolism of Tretinoin can be decreased when combined with Delavirdine.Approved, Investigational, Nutraceutical
TriamcinoloneThe metabolism of Triamcinolone can be decreased when combined with Delavirdine.Approved, Vet Approved
TriazolamThe metabolism of Triazolam can be decreased when combined with Delavirdine.Approved
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Delavirdine.Approved
TrimethoprimThe metabolism of Trimethoprim can be decreased when combined with Delavirdine.Approved, Vet Approved
TrimipramineThe metabolism of Trimipramine can be decreased when combined with Delavirdine.Approved
TroglitazoneThe metabolism of Troglitazone can be decreased when combined with Delavirdine.Withdrawn
TroleandomycinThe metabolism of Troleandomycin can be decreased when combined with Delavirdine.Approved
UbenimexThe serum concentration of Delavirdine can be decreased when it is combined with Ubenimex.Experimental
UdenafilThe metabolism of Udenafil can be decreased when combined with Delavirdine.Approved, Investigational
UlinastatinThe serum concentration of Delavirdine can be decreased when it is combined with Ulinastatin.Investigational
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Delavirdine.Approved
UmeclidiniumThe metabolism of Umeclidinium can be decreased when combined with Delavirdine.Approved
ValdecoxibThe metabolism of Valdecoxib can be decreased when combined with Delavirdine.Investigational, Withdrawn
Valproic AcidThe metabolism of Valproic Acid can be decreased when combined with Delavirdine.Approved, Investigational
ValsartanThe metabolism of Valsartan can be decreased when combined with Delavirdine.Approved, Investigational
VandetanibThe metabolism of Vandetanib can be decreased when combined with Delavirdine.Approved
VanoxerineThe metabolism of Vanoxerine can be decreased when combined with Delavirdine.Investigational
VardenafilThe metabolism of Vardenafil can be decreased when combined with Delavirdine.Approved
VemurafenibThe metabolism of Vemurafenib can be decreased when combined with Delavirdine.Approved
VenetoclaxThe metabolism of Venetoclax can be decreased when combined with Delavirdine.Approved
VenlafaxineThe metabolism of Venlafaxine can be decreased when combined with Delavirdine.Approved
VerapamilThe metabolism of Verapamil can be decreased when combined with Delavirdine.Approved
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Delavirdine.Investigational
VilanterolThe metabolism of Vilanterol can be decreased when combined with Delavirdine.Approved
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Delavirdine.Approved
VildagliptinThe serum concentration of Delavirdine can be decreased when it is combined with Vildagliptin.Approved, Investigational
VinblastineThe metabolism of Vinblastine can be decreased when combined with Delavirdine.Approved
VincristineThe metabolism of Vincristine can be decreased when combined with Delavirdine.Approved, Investigational
VindesineThe serum concentration of Vindesine can be increased when it is combined with Delavirdine.Approved
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Delavirdine.Approved, Investigational
VismodegibThe metabolism of Vismodegib can be decreased when combined with Delavirdine.Approved
VoriconazoleThe serum concentration of Voriconazole can be decreased when it is combined with Delavirdine.Approved, Investigational
VortioxetineThe serum concentration of Vortioxetine can be increased when it is combined with Delavirdine.Approved
WarfarinThe metabolism of Warfarin can be decreased when combined with Delavirdine.Approved
XimelagatranThe serum concentration of Delavirdine can be decreased when it is combined with Ximelagatran.Approved, Investigational, Withdrawn
Ym150The serum concentration of Delavirdine can be decreased when it is combined with Ym150.Investigational
YohimbineThe metabolism of Yohimbine can be decreased when combined with Delavirdine.Approved, Vet Approved
ZafirlukastThe metabolism of Zafirlukast can be decreased when combined with Delavirdine.Approved, Investigational
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Delavirdine.Approved
ZaleplonThe metabolism of Zaleplon can be decreased when combined with Delavirdine.Approved, Illicit, Investigational
ZaltoprofenThe metabolism of Zaltoprofen can be decreased when combined with Delavirdine.Approved
ZidovudineThe metabolism of Zidovudine can be decreased when combined with Delavirdine.Approved
ZileutonThe metabolism of Zileuton can be decreased when combined with Delavirdine.Approved, Investigational, Withdrawn
ZiprasidoneThe metabolism of Delavirdine can be decreased when combined with Ziprasidone.Approved
ZolpidemThe metabolism of Zolpidem can be decreased when combined with Delavirdine.Approved
ZomepiracThe metabolism of Zomepirac can be decreased when combined with Delavirdine.Withdrawn
ZonisamideThe metabolism of Zonisamide can be decreased when combined with Delavirdine.Approved, Investigational
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Delavirdine.Approved
ZuclopenthixolThe serum concentration of Zuclopenthixol can be increased when it is combined with Delavirdine.Approved, Investigational
Food Interactions
  • Take without regard to meals.
References
Synthesis Reference

DrugSyn.org

US5563142
General ReferencesNot Available
External Links
ATC CodesJ05AG02
AHFS Codes
  • 08:18.08.16
PDB EntriesNot Available
FDA labelDownload (645 KB)
MSDSNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+1.0
Blood Brain Barrier-0.6449
Caco-2 permeable-0.6231
P-glycoprotein substrateSubstrate0.7103
P-glycoprotein inhibitor IInhibitor0.7647
P-glycoprotein inhibitor IINon-inhibitor0.5644
Renal organic cation transporterNon-inhibitor0.7808
CYP450 2C9 substrateNon-substrate0.6717
CYP450 2D6 substrateSubstrate0.8918
CYP450 3A4 substrateSubstrate0.6707
CYP450 1A2 substrateNon-inhibitor0.6644
CYP450 2C9 inhibitorInhibitor0.6307
CYP450 2D6 inhibitorNon-inhibitor0.8556
CYP450 2C19 inhibitorNon-inhibitor0.6078
CYP450 3A4 inhibitorNon-inhibitor0.6383
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.9308
Ames testNon AMES toxic0.6189
CarcinogenicityNon-carcinogens0.7517
BiodegradationNot ready biodegradable0.9891
Rat acute toxicity2.5840 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.7656
hERG inhibition (predictor II)Inhibitor0.6118
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Viiv healthcare co
Packagers
Dosage forms
FormRouteStrength
TabletOral100 mg
TabletOral100 mg/1
TabletOral200 mg/1
Prices
Unit descriptionCostUnit
Rescriptor 200 mg tablet1.92USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2071529 No2001-03-202010-12-24Canada
CA2184598 No2005-05-032015-03-01Canada
US5563142 No1993-10-082013-10-08Us
US6177101 No1999-06-072019-06-07Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point226-228 °CNot Available
logP2.8Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.086 mg/mLALOGPS
logP2.77ALOGPS
logP1.02ChemAxon
logS-3.7ALOGPS
pKa (Strongest Acidic)9.39ChemAxon
pKa (Strongest Basic)6.82ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area110.43 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity126.64 m3·mol-1ChemAxon
Polarizability50.01 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as pyridinylpiperazines. These are compounds containing a pyridinylpiperazine skeleton, which consists of a pyridine linked (not fused) to a piperazine by a bond by a single bond that is not part of a ring.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassDiazinanes
Sub ClassPiperazines
Direct ParentPyridinylpiperazines
Alternative Parents
Substituents
  • N-arylpiperazine
  • Pyridinylpiperazine
  • Indolecarboxylic acid derivative
  • Indolecarboxamide derivative
  • Sulfanilide
  • Indole or derivatives
  • Indole
  • Dialkylarylamine
  • Pyrrole-2-carboxylic acid or derivatives
  • Pyrrole-2-carboxamide
  • Secondary aliphatic/aromatic amine
  • Aminopyridine
  • Imidolactam
  • Benzenoid
  • Substituted pyrrole
  • Pyridine
  • Heteroaromatic compound
  • Aminosulfonyl compound
  • Sulfonyl
  • Sulfonic acid derivative
  • Sulfonamide
  • Pyrrole
  • Tertiary amine
  • Carboxamide group
  • Azacycle
  • Secondary amine
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organosulfur compound
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Amine
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors

Targets

Kind
Protein
Organism
Human immunodeficiency virus 1
Pharmacological action
yes
Actions
inhibitor
General Function:
Rna-dna hybrid ribonuclease activity
Specific Function:
Not Available
Gene Name:
pol
Uniprot ID:
Q72547
Molecular Weight:
65223.615 Da
References
  1. Geitmann M, Unge T, Danielson UH: Biosensor-based kinetic characterization of the interaction between HIV-1 reverse transcriptase and non-nucleoside inhibitors. J Med Chem. 2006 Apr 20;49(8):2367-74. [PubMed:16610780 ]
  2. Xia Q, Radzio J, Anderson KS, Sluis-Cremer N: Probing nonnucleoside inhibitor-induced active-site distortion in HIV-1 reverse transcriptase by transient kinetic analyses. Protein Sci. 2007 Aug;16(8):1728-37. [PubMed:17656585 ]
  3. Freimuth WW: Delavirdine mesylate, a potent non-nucleoside HIV-1 reverse transcriptase inhibitor. Adv Exp Med Biol. 1996;394:279-89. [PubMed:8815692 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Voorman RL, Maio SM, Payne NA, Zhao Z, Koeplinger KA, Wang X: Microsomal metabolism of delavirdine: evidence for mechanism-based inactivation of human cytochrome P450 3A. J Pharmacol Exp Ther. 1998 Oct;287(1):381-8. [PubMed:9765359 ]
  4. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A5
Uniprot ID:
P20815
Molecular Weight:
57108.065 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A7
Uniprot ID:
P24462
Molecular Weight:
57525.03 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme...
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular Weight:
55824.275 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
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Drug created on June 13, 2005 07:24 / Updated on December 03, 2016 02:43