You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on DrugBank.
Identification
NameNevirapine
Accession NumberDB00238  (APRD00705, DB08311)
TypeSmall Molecule
GroupsApproved
DescriptionA potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS. [PubChem] Structurally, nevirapine belongs to the dipyridodiazepinone chemical class.
Structure
Thumb
Synonyms
11-Cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido(3,2-b:2',3'-e)(1,4)diazepin-6-one
NEV
Nevirapine
NVP
Viramune
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Auro-nevirapineTablet200 mgOralAurobindo Pharma Limited (Unit Iii)2010-12-29Not applicableCanada
Mylan-nevirapineTablet200 mgOralMylan Pharmaceuticals Ulc2012-06-20Not applicableCanada
NevirapineSuspension50 mg/5mLOralRoxane Laboratories, Inc.2012-05-21Not applicableUs
NevirapineTablet200 mg/1OralRoxane Laboratories, Inc.2012-05-21Not applicableUs
PMS-nevirapineTablet200 mgOralPharmascience Inc2013-06-03Not applicableCanada
Teva-nevirapineTablet200 mgOralTeva Canada Limited2011-02-01Not applicableCanada
ViramuneTablet, extended release400 mg/1OralPhysicians Total Care, Inc.2013-01-23Not applicableUs
ViramuneTablet, extended release400 mgOralBoehringer Ingelheim International Gmb H1998-02-05Not applicableEu
ViramuneTablet200 mgOralBoehringer Ingelheim International Gmb H1998-02-05Not applicableEu
ViramuneTablet, extended release100 mgOralBoehringer Ingelheim International Gmb H1998-02-05Not applicableEu
ViramuneTablet, extended release400 mg/1OralBoehringer Ingelheim Pharmaceuticals, Inc.2011-04-11Not applicableUs
ViramuneTablet, extended release400 mg/1OralA S Medication Solutions2011-04-11Not applicableUs
ViramuneTablet200 mgOralBoehringer Ingelheim (Canada) Ltd Ltee1998-09-17Not applicableCanada
ViramuneTablet200 mgOralBoehringer Ingelheim International Gmb H1998-02-05Not applicableEu
ViramuneTablet, extended release100 mg/1OralBoehringer Ingelheim Pharmaceuticals, Inc.2013-03-01Not applicableUs
ViramuneTablet, extended release400 mgOralBoehringer Ingelheim International Gmb H1998-02-05Not applicableEu
ViramuneTablet200 mgOralBoehringer Ingelheim International Gmb H1998-02-05Not applicableEu
ViramuneTablet200 mg/1OralBoehringer Ingelheim Pharmaceuticals Inc.2001-08-01Not applicableUs
ViramuneTablet200 mg/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
ViramuneTablet, extended release400 mgOralBoehringer Ingelheim International Gmb H1998-02-05Not applicableEu
ViramuneTablet, extended release50 mgOralBoehringer Ingelheim International Gmb H1998-02-05Not applicableEu
ViramuneSuspension50 mg/5mLOralBoehringer Ingelheim Pharmaceuticals Inc.2001-10-01Not applicableUs
ViramuneTablet200 mg/1OralA S Medication Solutions2001-08-01Not applicableUs
Viramune XRTablet, extended release400 mgOralBoehringer Ingelheim (Canada) Ltd Ltee2011-09-27Not applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-nevirapineTablet200 mgOralApotex IncNot applicableNot applicableCanada
Apo-nevirapine XRTablet, extended release400 mgOralApotex Inc2015-11-24Not applicableCanada
NevirapineTablet200 mg/1OralBreckenridge Pharmaceutical, Inc.2011-04-11Not applicableUs
NevirapineTablet200 mg/1OralMylan Pharmaceuticals Inc.2012-05-22Not applicableUs
NevirapineTablet, coated200 mg/1OralCarlsbad Technology, Inc.2016-01-01Not applicableUs
NevirapineTablet200 mg/1OralState of Florida DOH Central Pharmacy2014-11-01Not applicableUs
NevirapineTablet200 mg/1OralCamber Pharmaceuticals, Inc.2012-05-23Not applicableUs
NevirapineTablet200 mg/1OralCipla Limited2012-05-22Not applicableUs
NevirapineTablet200 mg/1OralAmneal Pharmaceuticals of New York, LLC2014-04-30Not applicableUs
NevirapineTablet, extended release400 mg/1OralMylan Pharmaceuticals Inc.2014-10-29Not applicableUs
NevirapineTablet, extended release100 mg/1OralAurobindo Pharma Limited2016-11-23Not applicableUs
NevirapineTablet200 mg/1OralGolden State Medical Supply, Inc.2012-05-22Not applicableUs
NevirapineTablet200 mg/1OralAlvogen Inc.2012-05-22Not applicableUs
NevirapineTablet, extended release400 mg/1OralCipla USA Inc.2015-10-15Not applicableUs
NevirapineTablet200 mg/1OralAmneal Agila, Llc2014-04-30Not applicableUs
NevirapineTablet200 mg/1OralAurobindo Pharma Limited2012-05-22Not applicableUs
NevirapineTablet, extended release100 mg/1OralMylan Pharmaceuticals Inc.2015-11-09Not applicableUs
NevirapineTablet200 mg/1OralApotex Corp2012-05-22Not applicableUs
NevirapineTablet200 mg/1OralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
NevirapineTablet, extended release400 mg/1OralSandoz Inc2014-04-15Not applicableUs
NevirapineTablet, extended release400 mg/1OralApotex Corp2014-04-15Not applicableUs
Nevirapine Extended ReleaseTablet400 mg/1OralAlvogen Inc.2015-07-14Not applicableUs
Nevirapine TevaTablet200 mgOralTeva B.V.  2009-11-30Not applicableEu
Nevirapine TevaTablet200 mgOralTeva B.V.  2009-11-30Not applicableEu
Nevirapine TevaTablet200 mgOralTeva B.V.  2009-11-30Not applicableEu
Nevirapine TevaTablet200 mgOralTeva B.V.  2009-11-30Not applicableEu
Nevirapine TevaTablet200 mgOralTeva B.V.  2009-11-30Not applicableEu
Nevirapine TevaTablet200 mgOralTeva B.V.  2009-11-30Not applicableEu
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixtures
NameLabellerIngredients
Apo-zidovudine-lamivudine-nevirapineApotex Inc
SaltsNot Available
Categories
UNII99DK7FVK1H
CAS number129618-40-2
WeightAverage: 266.2979
Monoisotopic: 266.11676109
Chemical FormulaC15H14N4O
InChI KeyNQDJXKOVJZTUJA-UHFFFAOYSA-N
InChI
InChI=1S/C15H14N4O/c1-9-6-8-17-14-12(9)18-15(20)11-3-2-7-16-13(11)19(14)10-4-5-10/h2-3,6-8,10H,4-5H2,1H3,(H,18,20)
IUPAC Name
2-cyclopropyl-7-methyl-2,4,9,15-tetraazatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3,5,7,12,14-hexaen-10-one
SMILES
CC1=C2NC(=O)C3=C(N=CC=C3)N(C3CC3)C2=NC=C1
Pharmacology
IndicationFor use in combination with other antiretroviral drugs in the ongoing treatment of HIV-1 infection.
Structured Indications
PharmacodynamicsNevirapine is a non-nucleoside reverse transcriptase inhibitor (nNRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1). HIV-2 RT and eukaryotic DNA polymerases (such as human DNA polymerases alpha, beta, or sigma) are not inhibited by nevirapine. Nevirapine is, in general, only prescribed after the immune system has declined and infections have become evident. It is always taken with at least one other HIV medication such as Retrovir or Videx. The virus can develop resistance to nevirapine if the drug is taken alone, although even if used properly, nevirapine is effective for only a limited time.
Mechanism of actionNevirapine binds directly to reverse transcriptase (RT) and blocks the RNA-dependent and DNA-dependent DNA polymerase activities by causing a disruption of the enzyme's catalytic site. The activity of nevirapine does not compete with template or nucleoside triphosphates.
TargetKindPharmacological actionActionsOrganismUniProt ID
Reverse transcriptase/RNaseHProteinyes
inhibitor
Human immunodeficiency virus 1Q72547 details
Related Articles
AbsorptionNevirapine is readily absorbed (greater than 90%) after oral administration in healthy subjects and adults with HIV-1 infection. The absolute bioavailability in healthy adults following a single dose administration is 93 ± 9% (mean ± SD) for a 50 mg tablet and 91 ± 8% for an oral solution. Peak plasma nevirapine concentrations of 2 ± 0.4 mcg/mL (7.5 micromolar) were attained by 4 hours following a single 200 mg dose. Nevirapine tablets and suspension have been shown to be comparably bioavailable and interchangeable at doses up to 200 mg. When the oral tablet is given with a high-fat meal, the extent of absorption is compared to that of the fasted-state.
Volume of distribution
  • 1.21 ± 0.09 L/kg [apparent volume of distribution, healthy adults, IV]
    Nevirapine is capable of crossing the placenta and is found in breast milk.
Protein binding60% bound to plasma protein.
Metabolism

Hepatic. In vivo studies in humans and in vitro studies with human liver microsomes have shown that nevirapine is extensively biotransformed via cytochrome P450 3A4 metabolism to several hydroxylated metabolites.

SubstrateEnzymesProduct
Nevirapine
12-HydroxynevirapineDetails
Nevirapine
2-HydroxynevirapineDetails
Nevirapine
8-HydroxynevirapineDetails
Nevirapine
3-HydroxynevirapineDetails
12-Hydroxynevirapine
Not Available
12-hydroxynevirapine glucuronideDetails
12-Hydroxynevirapine
4-carboxynevirapineDetails
2-Hydroxynevirapine
Not Available
2-hydroxynevirapine glucuronideDetails
8-Hydroxynevirapine
Not Available
8-hydroxynevirapine glucuronideDetails
3-Hydroxynevirapine
Not Available
3-hydroxynevirapine glucuronideDetails
Route of eliminationThus cytochrome P450 metabolism, glucuronide conjugation, and urinary excretion of glucuronidated metabolites represent the primary route of nevirapine biotransformation and elimination in humans. Only a small fraction (<5%) of the radioactivity in urine (representing <3% of the total dose) was made up of parent compound; therefore, renal excretion plays a minor role in elimination of the parent compound.
Half life45 hours
ClearanceNot Available
ToxicitySymptoms of overdose include edema, erythema nodosum, fatigue, fever, headache, insomnia, nausea, pulmonaryinfiltrates, rash, vertigo, vomiting, and weight decrease. The most common adverse reaction is rash.
Affected organisms
  • Human Immunodeficiency Virus
Pathways
PathwayCategorySMPDB ID
Nevirapine Action PathwayDrug actionSMP00743
Nevirapine Metabolism PathwayDrug metabolismSMP00642
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
16-BromoepiandrosteroneThe serum concentration of 16-Bromoepiandrosterone can be decreased when it is combined with Nevirapine.Investigational
19-norandrostenedioneThe serum concentration of 19-norandrostenedione can be decreased when it is combined with Nevirapine.Experimental, Illicit
4-AndrostenedioneThe serum concentration of 4-Androstenedione can be decreased when it is combined with Nevirapine.Experimental, Illicit
4-MethoxyamphetamineThe metabolism of 4-Methoxyamphetamine can be decreased when combined with Nevirapine.Experimental, Illicit
5-androstenedioneThe serum concentration of 5-androstenedione can be decreased when it is combined with Nevirapine.Experimental, Illicit
AbirateroneThe serum concentration of Abiraterone can be decreased when it is combined with Nevirapine.Approved
AcenocoumarolThe metabolism of Acenocoumarol can be increased when combined with Nevirapine.Approved
AcetaminophenThe metabolism of Acetaminophen can be increased when combined with Nevirapine.Approved
AcetylcholineThe metabolism of Acetylcholine can be decreased when combined with Nevirapine.Approved
AdinazolamThe metabolism of Adinazolam can be increased when combined with Nevirapine.Approved
AgomelatineThe serum concentration of Agomelatine can be increased when it is combined with Nevirapine.Approved, Investigational
AjmalineThe metabolism of Ajmaline can be decreased when combined with Nevirapine.Approved
AlbendazoleThe metabolism of Albendazole can be increased when combined with Nevirapine.Approved, Vet Approved
AlclometasoneThe metabolism of Alclometasone can be increased when combined with Nevirapine.Approved
AldosteroneThe serum concentration of Aldosterone can be decreased when it is combined with Nevirapine.Experimental
AlfentanilThe metabolism of Alfentanil can be increased when combined with Nevirapine.Approved, Illicit
AlfuzosinThe metabolism of Alfuzosin can be increased when combined with Nevirapine.Approved, Investigational
AliskirenThe metabolism of Aliskiren can be increased when combined with Nevirapine.Approved, Investigational
AllylestrenolThe metabolism of Allylestrenol can be increased when combined with Nevirapine.Approved
AlmotriptanThe metabolism of Almotriptan can be increased when combined with Nevirapine.Approved, Investigational
AlogliptinThe metabolism of Alogliptin can be increased when combined with Nevirapine.Approved
AlosetronThe metabolism of Alosetron can be increased when combined with Nevirapine.Approved, Withdrawn
AlprazolamThe metabolism of Alprazolam can be increased when combined with Nevirapine.Approved, Illicit, Investigational
AlprenololThe metabolism of Alprenolol can be decreased when combined with Nevirapine.Approved, Withdrawn
AmbrisentanThe metabolism of Ambrisentan can be increased when combined with Nevirapine.Approved, Investigational
AmbroxolThe metabolism of Ambroxol can be increased when combined with Nevirapine.Approved
AmcinonideThe serum concentration of Amcinonide can be decreased when it is combined with Nevirapine.Approved
AminophenazoneThe metabolism of Aminophenazone can be increased when combined with Nevirapine.Approved, Withdrawn
AminophyllineThe metabolism of Aminophylline can be increased when combined with Nevirapine.Approved
AmiodaroneThe metabolism of Amiodarone can be increased when combined with Nevirapine.Approved, Investigational
AmitriptylineThe metabolism of Amitriptyline can be increased when combined with Nevirapine.Approved
AmlodipineThe metabolism of Amlodipine can be increased when combined with Nevirapine.Approved
AmoxapineThe metabolism of Amoxapine can be decreased when combined with Nevirapine.Approved
AmphetamineThe metabolism of Amphetamine can be decreased when combined with Nevirapine.Approved, Illicit
AmprenavirThe metabolism of Amprenavir can be increased when combined with Nevirapine.Approved
AmsacrineThe metabolism of Amsacrine can be decreased when combined with Nevirapine.Approved
AnagrelideThe metabolism of Anagrelide can be decreased when combined with Nevirapine.Approved
AnecortaveThe serum concentration of Anecortave can be decreased when it is combined with Nevirapine.Investigational
AntipyrineThe metabolism of Antipyrine can be increased when combined with Nevirapine.Approved
ApixabanThe serum concentration of Apixaban can be decreased when it is combined with Nevirapine.Approved
ApremilastThe serum concentration of Apremilast can be decreased when it is combined with Nevirapine.Approved, Investigational
AprepitantThe serum concentration of Nevirapine can be increased when it is combined with Aprepitant.Approved, Investigational
AprindineThe metabolism of Aprindine can be decreased when combined with Nevirapine.Approved
ArformoterolThe metabolism of Arformoterol can be decreased when combined with Nevirapine.Approved, Investigational
ArgatrobanThe metabolism of Argatroban can be increased when combined with Nevirapine.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be decreased when it is combined with Nevirapine.Approved, Investigational
ArtemetherThe serum concentration of Artemether can be decreased when it is combined with Nevirapine.Approved
ArtesunateThe serum concentration of the active metabolites of Artesunate can be reduced when Artesunate is used in combination with Nevirapine resulting in a loss in efficacy.Approved
ASA404The metabolism of ASA404 can be decreased when combined with Nevirapine.Investigational
AsenapineThe metabolism of Asenapine can be increased when combined with Nevirapine.Approved
AstemizoleThe metabolism of Astemizole can be increased when combined with Nevirapine.Approved, Withdrawn
AtazanavirThe serum concentration of Nevirapine can be increased when it is combined with Atazanavir.Approved, Investigational
AtomoxetineThe metabolism of Nevirapine can be decreased when combined with Atomoxetine.Approved
AtorvastatinThe metabolism of Atorvastatin can be increased when combined with Nevirapine.Approved
AV650The metabolism of AV650 can be decreased when combined with Nevirapine.Approved, Investigational
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Nevirapine.Approved
AxitinibThe serum concentration of Axitinib can be decreased when it is combined with Nevirapine.Approved, Investigational
AzelastineThe metabolism of Azelastine can be increased when combined with Nevirapine.Approved
AzithromycinThe metabolism of Azithromycin can be increased when combined with Nevirapine.Approved
BanoxantroneThe metabolism of Banoxantrone can be increased when combined with Nevirapine.Investigational
BeclomethasoneThe serum concentration of Beclomethasone can be decreased when it is combined with Nevirapine.Investigational
Beclomethasone dipropionateThe serum concentration of Beclomethasone dipropionate can be decreased when it is combined with Nevirapine.Approved, Investigational
BedaquilineThe serum concentration of Bedaquiline can be decreased when it is combined with Nevirapine.Approved
BendamustineThe metabolism of Bendamustine can be decreased when combined with Nevirapine.Approved, Investigational
BenzatropineThe metabolism of Benzatropine can be decreased when combined with Nevirapine.Approved
BenzphetamineThe metabolism of Benzphetamine can be increased when combined with Nevirapine.Approved, Illicit
Benzyl alcoholThe metabolism of Benzyl alcohol can be increased when combined with Nevirapine.Approved
BepridilThe metabolism of Bepridil can be decreased when combined with Nevirapine.Approved, Withdrawn
BetamethasoneThe serum concentration of Betamethasone can be decreased when it is combined with Nevirapine.Approved, Vet Approved
BetaxololThe metabolism of Betaxolol can be decreased when combined with Nevirapine.Approved
BexaroteneThe metabolism of Bexarotene can be increased when combined with Nevirapine.Approved, Investigational
BezafibrateThe metabolism of Bezafibrate can be increased when combined with Nevirapine.Approved
BicalutamideThe metabolism of Bicalutamide can be increased when combined with Nevirapine.Approved
BisoprololThe metabolism of Bisoprolol can be increased when combined with Nevirapine.Approved
BoceprevirThe serum concentration of Boceprevir can be decreased when it is combined with Nevirapine.Approved
BortezomibThe serum concentration of Bortezomib can be decreased when it is combined with Nevirapine.Approved, Investigational
BosentanThe serum concentration of Bosentan can be increased when it is combined with Nevirapine.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Nevirapine.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be decreased when it is combined with Nevirapine.Approved
BrexpiprazoleThe serum concentration of Brexpiprazole can be decreased when it is combined with Nevirapine.Approved
BrinzolamideThe metabolism of Brinzolamide can be increased when combined with Nevirapine.Approved
BromazepamThe metabolism of Bromazepam can be increased when combined with Nevirapine.Approved, Illicit
BromocriptineThe metabolism of Bromocriptine can be increased when combined with Nevirapine.Approved, Investigational
BrompheniramineThe metabolism of Brompheniramine can be increased when combined with Nevirapine.Approved
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Nevirapine.Approved
BudesonideThe metabolism of Budesonide can be increased when combined with Nevirapine.Approved
BufuralolThe metabolism of Bufuralol can be decreased when combined with Nevirapine.Experimental, Investigational
BupivacaineThe metabolism of Bupivacaine can be increased when combined with Nevirapine.Approved, Investigational
BuprenorphineThe metabolism of Buprenorphine can be increased when combined with Nevirapine.Approved, Illicit, Investigational, Vet Approved
BupropionThe metabolism of Bupropion can be increased when combined with Nevirapine.Approved
BuspironeThe metabolism of Buspirone can be increased when combined with Nevirapine.Approved, Investigational
BusulfanThe metabolism of Busulfan can be increased when combined with Nevirapine.Approved, Investigational
CabazitaxelThe metabolism of Cabazitaxel can be increased when combined with Nevirapine.Approved
CabergolineThe metabolism of Cabergoline can be increased when combined with Nevirapine.Approved
CabozantinibThe serum concentration of Cabozantinib can be decreased when it is combined with Nevirapine.Approved
CaffeineThe metabolism of Caffeine can be increased when combined with Nevirapine.Approved
CalcitriolThe metabolism of Calcitriol can be increased when combined with Nevirapine.Approved, Nutraceutical
CanagliflozinThe metabolism of Canagliflozin can be increased when combined with Nevirapine.Approved
CannabidiolThe serum concentration of Cannabidiol can be decreased when it is combined with Nevirapine.Approved, Investigational
CapecitabineThe metabolism of Nevirapine can be decreased when combined with Capecitabine.Approved, Investigational
CaptoprilThe metabolism of Captopril can be decreased when combined with Nevirapine.Approved
CarbamazepineThe serum concentration of Nevirapine can be decreased when it is combined with Carbamazepine.Approved, Investigational
CarbinoxamineThe metabolism of Carbinoxamine can be increased when combined with Nevirapine.Approved
CariprazineThe metabolism of Cariprazine can be increased when combined with Nevirapine.Approved
CarmustineThe metabolism of Carmustine can be decreased when combined with Nevirapine.Approved
CarteololThe metabolism of Carteolol can be decreased when combined with Nevirapine.Approved
CarvedilolThe metabolism of Carvedilol can be increased when combined with Nevirapine.Approved, Investigational
CaspofunginThe serum concentration of Caspofungin can be decreased when it is combined with Nevirapine.Approved
CelecoxibThe metabolism of Celecoxib can be increased when combined with Nevirapine.Approved, Investigational
CeliprololThe metabolism of Celiprolol can be increased when combined with Nevirapine.Approved, Investigational
CephalexinThe metabolism of Cephalexin can be increased when combined with Nevirapine.Approved, Vet Approved
CeritinibThe serum concentration of Ceritinib can be decreased when it is combined with Nevirapine.Approved
CerivastatinThe metabolism of Cerivastatin can be increased when combined with Nevirapine.Withdrawn
CevimelineThe metabolism of Cevimeline can be increased when combined with Nevirapine.Approved
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be increased when combined with Nevirapine.Approved
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be increased when combined with Nevirapine.Approved, Illicit
ChloroquineThe metabolism of Chloroquine can be increased when combined with Nevirapine.Approved, Vet Approved
ChlorotrianiseneThe serum concentration of Chlorotrianisene can be decreased when it is combined with Nevirapine.Withdrawn
ChlorphenamineThe metabolism of Chlorphenamine can be increased when combined with Nevirapine.Approved
ChlorpromazineThe metabolism of Chlorpromazine can be increased when combined with Nevirapine.Approved, Vet Approved
ChlorzoxazoneThe metabolism of Chlorzoxazone can be increased when combined with Nevirapine.Approved
CholecalciferolThe metabolism of Cholecalciferol can be increased when combined with Nevirapine.Approved, Nutraceutical
CiclesonideThe metabolism of Ciclesonide can be increased when combined with Nevirapine.Approved, Investigational
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Nevirapine.Approved
CimetidineThe metabolism of Nevirapine can be decreased when combined with Cimetidine.Approved
CinacalcetThe metabolism of Cinacalcet can be increased when combined with Nevirapine.Approved
CinnarizineThe metabolism of Cinnarizine can be increased when combined with Nevirapine.Approved
CisaprideThe metabolism of Cisapride can be increased when combined with Nevirapine.Approved, Investigational, Withdrawn
CitalopramThe metabolism of Citalopram can be increased when combined with Nevirapine.Approved
ClarithromycinThe serum concentration of the active metabolites of Clarithromycin can be increased when Clarithromycin is used in combination with Nevirapine.Approved
ClemastineThe metabolism of Nevirapine can be decreased when combined with Clemastine.Approved
ClenbuterolThe metabolism of Clenbuterol can be decreased when combined with Nevirapine.Approved, Vet Approved
ClevidipineThe metabolism of Clevidipine can be decreased when combined with Nevirapine.Approved
ClindamycinThe metabolism of Clindamycin can be increased when combined with Nevirapine.Approved, Vet Approved
ClobazamThe metabolism of Clobazam can be increased when combined with Nevirapine.Approved, Illicit
ClobetasolThe serum concentration of Clobetasol can be decreased when it is combined with Nevirapine.Investigational
Clobetasol propionateThe serum concentration of Clobetasol propionate can be decreased when it is combined with Nevirapine.Approved
ClocortoloneThe serum concentration of Clocortolone can be decreased when it is combined with Nevirapine.Approved
ClofazimineThe metabolism of Clofazimine can be increased when combined with Nevirapine.Approved, Investigational
ClofibrateThe metabolism of Clofibrate can be increased when combined with Nevirapine.Approved
clomethiazoleThe metabolism of clomethiazole can be increased when combined with Nevirapine.Investigational
ClomipramineThe metabolism of Clomipramine can be increased when combined with Nevirapine.Approved, Vet Approved
ClonazepamThe metabolism of Clonazepam can be increased when combined with Nevirapine.Approved, Illicit
ClonidineThe metabolism of Clonidine can be increased when combined with Nevirapine.Approved
ClopidogrelThe metabolism of Clopidogrel can be increased when combined with Nevirapine.Approved, Nutraceutical
ClorazepateThe metabolism of Clorazepate can be increased when combined with Nevirapine.Approved, Illicit
ClotiazepamThe metabolism of Clotiazepam can be increased when combined with Nevirapine.Approved, Illicit
ClotrimazoleThe metabolism of Nevirapine can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineThe serum concentration of Clozapine can be decreased when it is combined with Nevirapine.Approved
CobicistatThe serum concentration of Nevirapine can be increased when it is combined with Cobicistat.Approved
CobimetinibThe serum concentration of Cobimetinib can be decreased when it is combined with Nevirapine.Approved
CocaineThe metabolism of Cocaine can be increased when combined with Nevirapine.Approved, Illicit
CodeineThe therapeutic efficacy of Codeine can be decreased when used in combination with Nevirapine.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Nevirapine.Approved
ConivaptanThe serum concentration of Nevirapine can be increased when it is combined with Conivaptan.Approved, Investigational
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be decreased when it is combined with Nevirapine.Approved
Cortisone acetateThe metabolism of Cortisone acetate can be increased when combined with Nevirapine.Approved
CrizotinibThe serum concentration of Crizotinib can be decreased when it is combined with Nevirapine.Approved
CyclobenzaprineThe metabolism of Cyclobenzaprine can be increased when combined with Nevirapine.Approved
CyclophosphamideThe metabolism of Cyclophosphamide can be increased when combined with Nevirapine.Approved, Investigational
CyclosporineThe metabolism of Cyclosporine can be increased when combined with Nevirapine.Approved, Investigational, Vet Approved
CytarabineThe metabolism of Cytarabine can be increased when combined with Nevirapine.Approved, Investigational
DabrafenibThe serum concentration of Nevirapine can be decreased when it is combined with Dabrafenib.Approved
DacarbazineThe metabolism of Dacarbazine can be decreased when combined with Nevirapine.Approved, Investigational
DaclatasvirThe serum concentration of Daclatasvir can be decreased when it is combined with Nevirapine.Approved
DantroleneThe metabolism of Dantrolene can be increased when combined with Nevirapine.Approved
DapagliflozinThe metabolism of Dapagliflozin can be increased when combined with Nevirapine.Approved
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Nevirapine.Investigational
DapsoneThe metabolism of Dapsone can be increased when combined with Nevirapine.Approved, Investigational
DarifenacinThe metabolism of Darifenacin can be increased when combined with Nevirapine.Approved, Investigational
DarunavirThe serum concentration of Nevirapine can be increased when it is combined with Darunavir.Approved
DasabuvirThe metabolism of Dasabuvir can be increased when combined with Nevirapine.Approved
DasatinibThe serum concentration of Dasatinib can be decreased when it is combined with Nevirapine.Approved, Investigational
DaunorubicinThe metabolism of Daunorubicin can be increased when combined with Nevirapine.Approved
DebrisoquinThe metabolism of Debrisoquin can be decreased when combined with Nevirapine.Approved
DeferasiroxThe serum concentration of Nevirapine can be decreased when it is combined with Deferasirox.Approved, Investigational
dehydroepiandrosterone sulfateThe serum concentration of dehydroepiandrosterone sulfate can be decreased when it is combined with Nevirapine.Investigational
DelavirdineThe metabolism of Delavirdine can be increased when combined with Nevirapine.Approved
DesipramineThe metabolism of Desipramine can be decreased when combined with Nevirapine.Approved
DesogestrelThe serum concentration of Desogestrel can be decreased when it is combined with Nevirapine.Approved
DesoximetasoneThe serum concentration of Desoximetasone can be decreased when it is combined with Nevirapine.Approved
Desoxycorticosterone acetateThe serum concentration of Desoxycorticosterone acetate can be decreased when it is combined with Nevirapine.Approved
Desoxycorticosterone PivalateThe serum concentration of Desoxycorticosterone Pivalate can be decreased when it is combined with Nevirapine.Experimental, Vet Approved
DesvenlafaxineThe metabolism of Desvenlafaxine can be increased when combined with Nevirapine.Approved
DexamethasoneThe serum concentration of Dexamethasone can be decreased when it is combined with Nevirapine.Approved, Investigational, Vet Approved
DexamethasoneThe metabolism of Dexamethasone can be increased when combined with Nevirapine.Approved, Investigational, Vet Approved
Dexamethasone isonicotinateThe serum concentration of Dexamethasone isonicotinate can be decreased when it is combined with Nevirapine.Vet Approved
DexfenfluramineThe metabolism of Dexfenfluramine can be decreased when combined with Nevirapine.Approved, Illicit, Withdrawn
DexmethylphenidateThe metabolism of Dexmethylphenidate can be decreased when combined with Nevirapine.Approved
DextroamphetamineThe metabolism of Dextroamphetamine can be decreased when combined with Nevirapine.Approved, Illicit
DextromethorphanThe metabolism of Dextromethorphan can be increased when combined with Nevirapine.Approved
DextropropoxypheneThe metabolism of Dextropropoxyphene can be increased when combined with Nevirapine.Approved, Illicit, Withdrawn
DiazepamThe metabolism of Diazepam can be increased when combined with Nevirapine.Approved, Illicit, Vet Approved
DiclofenacThe metabolism of Diclofenac can be increased when combined with Nevirapine.Approved, Vet Approved
DienestrolThe serum concentration of Dienestrol can be decreased when it is combined with Nevirapine.Approved
DienogestThe serum concentration of Dienogest can be decreased when it is combined with Nevirapine.Approved
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be decreased when it is combined with Nevirapine.Approved
DiflorasoneThe serum concentration of Diflorasone can be decreased when it is combined with Nevirapine.Approved
DifluocortoloneThe serum concentration of Difluocortolone can be decreased when it is combined with Nevirapine.Approved
DifluprednateThe serum concentration of Difluprednate can be decreased when it is combined with Nevirapine.Approved
DigitoxinThe metabolism of Digitoxin can be increased when combined with Nevirapine.Approved
DigoxinThe metabolism of Digoxin can be increased when combined with Nevirapine.Approved
DihydrocodeineThe metabolism of Dihydrocodeine can be increased when combined with Nevirapine.Approved, Illicit
DihydroergotamineThe metabolism of Dihydroergotamine can be increased when combined with Nevirapine.Approved
DiltiazemThe metabolism of Diltiazem can be increased when combined with Nevirapine.Approved
DinoprostoneThe metabolism of Dinoprostone can be decreased when combined with Nevirapine.Approved
DiphenhydramineThe metabolism of Diphenhydramine can be increased when combined with Nevirapine.Approved
DisopyramideThe metabolism of Disopyramide can be increased when combined with Nevirapine.Approved
DisulfiramThe metabolism of Disulfiram can be increased when combined with Nevirapine.Approved
DocetaxelThe metabolism of Docetaxel can be increased when combined with Nevirapine.Approved, Investigational
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Nevirapine.Approved
DolasetronThe metabolism of Dolasetron can be increased when combined with Nevirapine.Approved
DolutegravirThe serum concentration of Dolutegravir can be decreased when it is combined with Nevirapine.Approved
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Nevirapine.Approved, Investigational, Vet Approved
DonepezilThe metabolism of Donepezil can be increased when combined with Nevirapine.Approved
DopamineThe metabolism of Dopamine can be decreased when combined with Nevirapine.Approved
DorzolamideThe metabolism of Dorzolamide can be increased when combined with Nevirapine.Approved
DoxazosinThe metabolism of Doxazosin can be decreased when combined with Nevirapine.Approved
DoxepinThe metabolism of Doxepin can be increased when combined with Nevirapine.Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Nevirapine.Approved, Investigational
DoxorubicinThe metabolism of Doxorubicin can be increased when combined with Nevirapine.Approved, Investigational
DoxycyclineThe metabolism of Nevirapine can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Nevirapine.Approved, Illicit
DronedaroneThe serum concentration of Dronedarone can be decreased when it is combined with Nevirapine.Approved
DrospirenoneThe serum concentration of Drospirenone can be decreased when it is combined with Nevirapine.Approved
DuloxetineThe metabolism of Duloxetine can be decreased when combined with Nevirapine.Approved
DutasterideThe metabolism of Dutasteride can be increased when combined with Nevirapine.Approved, Investigational
EfavirenzThe risk or severity of adverse effects can be increased when Efavirenz is combined with Nevirapine.Approved, Investigational
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Nevirapine.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be decreased when it is combined with Nevirapine.Approved
EltrombopagThe metabolism of Eltrombopag can be decreased when combined with Nevirapine.Approved
ElvitegravirThe serum concentration of Elvitegravir can be decreased when it is combined with Nevirapine.Approved
EnalaprilThe metabolism of Enalapril can be increased when combined with Nevirapine.Approved, Vet Approved
EncainideThe metabolism of Encainide can be decreased when combined with Nevirapine.Approved, Withdrawn
EnclomipheneThe metabolism of Enclomiphene can be decreased when combined with Nevirapine.Investigational
EnzalutamideThe serum concentration of Enzalutamide can be decreased when it is combined with Nevirapine.Approved
EpinastineThe metabolism of Epinastine can be increased when combined with Nevirapine.Approved, Investigational
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Nevirapine.Approved
EquileninThe serum concentration of Equilenin can be decreased when it is combined with Nevirapine.Experimental
EquilinThe serum concentration of Equilin can be decreased when it is combined with Nevirapine.Approved
ErgocalciferolThe metabolism of Ergocalciferol can be increased when combined with Nevirapine.Approved, Nutraceutical
Ergoloid mesylateThe metabolism of Ergoloid mesylate can be increased when combined with Nevirapine.Approved
ErgonovineThe metabolism of Ergonovine can be increased when combined with Nevirapine.Approved
ErgotamineThe metabolism of Ergotamine can be increased when combined with Nevirapine.Approved
ErlotinibThe serum concentration of Erlotinib can be decreased when it is combined with Nevirapine.Approved, Investigational
ErythromycinThe metabolism of Erythromycin can be increased when combined with Nevirapine.Approved, Vet Approved
EscitalopramThe metabolism of Escitalopram can be increased when combined with Nevirapine.Approved, Investigational
Eslicarbazepine acetateThe serum concentration of Nevirapine can be decreased when it is combined with Eslicarbazepine acetate.Approved
EsmirtazapineThe metabolism of Esmirtazapine can be decreased when combined with Nevirapine.Investigational
EsomeprazoleThe metabolism of Esomeprazole can be increased when combined with Nevirapine.Approved, Investigational
EstazolamThe metabolism of Estazolam can be increased when combined with Nevirapine.Approved, Illicit
EstradiolThe serum concentration of Estradiol can be decreased when it is combined with Nevirapine.Approved, Investigational, Vet Approved
Estradiol valerate/DienogestThe metabolism of Estradiol valerate/Dienogest can be increased when combined with Nevirapine.Approved
EstramustineThe serum concentration of Estramustine can be decreased when it is combined with Nevirapine.Approved
Estrogens, esterifiedThe serum concentration of Estrogens, esterified can be decreased when it is combined with Nevirapine.Approved
EstroneThe metabolism of Estrone can be increased when combined with Nevirapine.Approved
Estrone sulfateThe serum concentration of Estrone sulfate can be decreased when it is combined with Nevirapine.Approved
EszopicloneThe metabolism of Eszopiclone can be increased when combined with Nevirapine.Approved
EthanolThe metabolism of Ethanol can be increased when combined with Nevirapine.Approved
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Nevirapine.Approved
EthosuximideThe metabolism of Ethosuximide can be increased when combined with Nevirapine.Approved
EthylmorphineThe metabolism of Ethylmorphine can be increased when combined with Nevirapine.Approved, Illicit
Ethynodiol diacetateThe serum concentration of Ethynodiol diacetate can be decreased when it is combined with Nevirapine.Approved
EtonogestrelThe serum concentration of Etonogestrel can be decreased when it is combined with Nevirapine.Approved, Investigational
EtoposideThe serum concentration of Etoposide can be decreased when it is combined with Nevirapine.Approved
EtoricoxibThe metabolism of Etoricoxib can be increased when combined with Nevirapine.Approved, Investigational
EtravirineThe serum concentration of Etravirine can be decreased when it is combined with Nevirapine.Approved
EverolimusThe serum concentration of Everolimus can be decreased when it is combined with Nevirapine.Approved
ExemestaneThe serum concentration of Exemestane can be decreased when it is combined with Nevirapine.Approved, Investigational
FamciclovirThe metabolism of Famciclovir can be increased when combined with Nevirapine.Approved
FelbamateThe metabolism of Felbamate can be increased when combined with Nevirapine.Approved
FelodipineThe metabolism of Felodipine can be increased when combined with Nevirapine.Approved, Investigational
FenofibrateThe metabolism of Fenofibrate can be increased when combined with Nevirapine.Approved
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Nevirapine.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Nevirapine.Approved
FinasterideThe metabolism of Finasteride can be increased when combined with Nevirapine.Approved
FingolimodThe metabolism of Fingolimod can be increased when combined with Nevirapine.Approved, Investigational
FlecainideThe metabolism of Flecainide can be decreased when combined with Nevirapine.Approved, Withdrawn
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Nevirapine.Approved
FloxuridineThe metabolism of Nevirapine can be decreased when combined with Floxuridine.Approved
fluasteroneThe serum concentration of fluasterone can be decreased when it is combined with Nevirapine.Investigational
FluconazoleThe serum concentration of Nevirapine can be increased when it is combined with Fluconazole.Approved
FludrocortisoneThe serum concentration of Fludrocortisone can be decreased when it is combined with Nevirapine.Approved
FlumethasoneThe serum concentration of Flumethasone can be decreased when it is combined with Nevirapine.Approved, Vet Approved
FlunarizineThe metabolism of Flunarizine can be increased when combined with Nevirapine.Approved
FlunisolideThe metabolism of Flunisolide can be increased when combined with Nevirapine.Approved, Investigational
FlunitrazepamThe metabolism of Flunitrazepam can be increased when combined with Nevirapine.Approved, Illicit
Fluocinolone AcetonideThe serum concentration of Fluocinolone Acetonide can be decreased when it is combined with Nevirapine.Approved, Investigational, Vet Approved
FluocinonideThe serum concentration of Fluocinonide can be decreased when it is combined with Nevirapine.Approved, Investigational
FluocortoloneThe serum concentration of Fluocortolone can be decreased when it is combined with Nevirapine.Approved, Withdrawn
FluorometholoneThe metabolism of Fluorometholone can be increased when combined with Nevirapine.Approved
FluorouracilThe metabolism of Nevirapine can be decreased when combined with Fluorouracil.Approved
FluoxetineThe metabolism of Fluoxetine can be increased when combined with Nevirapine.Approved, Vet Approved
FluphenazineThe metabolism of Fluphenazine can be decreased when combined with Nevirapine.Approved
FluprednideneThe serum concentration of Fluprednidene can be decreased when it is combined with Nevirapine.Approved, Withdrawn
FluprednisoloneThe serum concentration of Fluprednisolone can be decreased when it is combined with Nevirapine.Approved
FlurandrenolideThe serum concentration of Flurandrenolide can be decreased when it is combined with Nevirapine.Approved
FlurazepamThe metabolism of Flurazepam can be increased when combined with Nevirapine.Approved, Illicit
FlutamideThe metabolism of Flutamide can be increased when combined with Nevirapine.Approved
Fluticasone furoateThe metabolism of Fluticasone furoate can be increased when combined with Nevirapine.Approved
Fluticasone PropionateThe metabolism of Fluticasone Propionate can be increased when combined with Nevirapine.Approved
FluvastatinThe metabolism of Fluvastatin can be increased when combined with Nevirapine.Approved
FluvoxamineThe metabolism of Nevirapine can be decreased when combined with Fluvoxamine.Approved, Investigational
FormestaneThe serum concentration of Formestane can be decreased when it is combined with Nevirapine.Approved, Investigational, Withdrawn
FormoterolThe metabolism of Formoterol can be decreased when combined with Nevirapine.Approved, Investigational
FosamprenavirThe serum concentration of the active metabolites of Fosamprenavir can be reduced when Fosamprenavir is used in combination with Nevirapine resulting in a loss in efficacy.Approved
FosaprepitantThe serum concentration of Nevirapine can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinThe metabolism of Nevirapine can be increased when combined with Fosphenytoin.Approved
FrovatriptanThe metabolism of Frovatriptan can be decreased when combined with Nevirapine.Approved, Investigational
FulvestrantThe metabolism of Fulvestrant can be increased when combined with Nevirapine.Approved, Investigational
Fusidic AcidThe serum concentration of Nevirapine can be increased when it is combined with Fusidic Acid.Approved
GalantamineThe metabolism of Galantamine can be increased when combined with Nevirapine.Approved
GefitinibThe serum concentration of Gefitinib can be decreased when it is combined with Nevirapine.Approved, Investigational
GemfibrozilThe metabolism of Gemfibrozil can be increased when combined with Nevirapine.Approved
GenisteinThe metabolism of Genistein can be decreased when combined with Nevirapine.Investigational
GestodeneThe serum concentration of Gestodene can be decreased when it is combined with Nevirapine.Approved
GlipizideThe metabolism of Glipizide can be increased when combined with Nevirapine.Approved
GlyburideThe metabolism of Glyburide can be increased when combined with Nevirapine.Approved
GranisetronThe metabolism of Granisetron can be increased when combined with Nevirapine.Approved, Investigational
GrepafloxacinThe metabolism of Grepafloxacin can be increased when combined with Nevirapine.Withdrawn
GuanabenzThe metabolism of Guanabenz can be decreased when combined with Nevirapine.Approved
GuanfacineThe serum concentration of Guanfacine can be decreased when it is combined with Nevirapine.Approved, Investigational
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Nevirapine.Approved
HaloperidolThe metabolism of Haloperidol can be increased when combined with Nevirapine.Approved
HalothaneThe metabolism of Halothane can be increased when combined with Nevirapine.Approved, Vet Approved
HE3286The serum concentration of HE3286 can be decreased when it is combined with Nevirapine.Investigational
HesperetinThe metabolism of Hesperetin can be decreased when combined with Nevirapine.Approved
HexestrolThe serum concentration of Hexestrol can be decreased when it is combined with Nevirapine.Withdrawn
HexobarbitalThe metabolism of Hexobarbital can be increased when combined with Nevirapine.Approved
Histamine PhosphateThe metabolism of Histamine Phosphate can be increased when combined with Nevirapine.Approved
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Nevirapine.Approved, Illicit
HydrocortisoneThe metabolism of Hydrocortisone can be increased when combined with Nevirapine.Approved, Vet Approved
HydrocortisoneThe serum concentration of Hydrocortisone can be decreased when it is combined with Nevirapine.Approved, Vet Approved
HydromorphoneThe metabolism of Hydromorphone can be increased when combined with Nevirapine.Approved, Illicit
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be increased when combined with Nevirapine.Approved
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Nevirapine.Approved
IdarubicinThe metabolism of Idarubicin can be decreased when combined with Nevirapine.Approved
IdelalisibThe serum concentration of Nevirapine can be increased when it is combined with Idelalisib.Approved
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Nevirapine resulting in a loss in efficacy.Approved
IloperidoneThe metabolism of Iloperidone can be increased when combined with Nevirapine.Approved
ImatinibThe serum concentration of Imatinib can be decreased when it is combined with Nevirapine.Approved
ImipramineThe metabolism of Imipramine can be increased when combined with Nevirapine.Approved
ImiquimodThe metabolism of Imiquimod can be increased when combined with Nevirapine.Approved, Investigational
IndacaterolThe metabolism of Indacaterol can be increased when combined with Nevirapine.Approved
IndapamideThe metabolism of Indapamide can be increased when combined with Nevirapine.Approved
IndinavirThe serum concentration of Indinavir can be decreased when it is combined with Nevirapine.Approved
Ipratropium bromideThe metabolism of Ipratropium bromide can be increased when combined with Nevirapine.Approved
IrbesartanThe metabolism of Nevirapine can be decreased when combined with Irbesartan.Approved, Investigational
IrinotecanThe serum concentration of the active metabolites of Irinotecan can be reduced when Irinotecan is used in combination with Nevirapine resulting in a loss in efficacy.Approved, Investigational
IsavuconazoniumThe serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Nevirapine resulting in a loss in efficacy.Approved, Investigational
IsofluraneThe metabolism of Isoflurane can be increased when combined with Nevirapine.Approved, Vet Approved
IsoniazidThe metabolism of Nevirapine can be decreased when combined with Isoniazid.Approved
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be increased when combined with Nevirapine.Approved
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be increased when combined with Nevirapine.Approved
IsradipineThe metabolism of Isradipine can be increased when combined with Nevirapine.Approved
IstaroximeThe serum concentration of Istaroxime can be decreased when it is combined with Nevirapine.Investigational
ItraconazoleThe serum concentration of Itraconazole can be decreased when it is combined with Nevirapine.Approved, Investigational
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Nevirapine.Approved
IvacaftorThe serum concentration of Ivacaftor can be decreased when it is combined with Nevirapine.Approved
IvermectinThe metabolism of Ivermectin can be increased when combined with Nevirapine.Approved, Vet Approved
IxabepiloneThe serum concentration of Ixabepilone can be decreased when it is combined with Nevirapine.Approved, Investigational
IxazomibThe serum concentration of Ixazomib can be decreased when it is combined with Nevirapine.Approved
KetamineThe metabolism of Ketamine can be increased when combined with Nevirapine.Approved, Vet Approved
KetazolamThe metabolism of Ketazolam can be increased when combined with Nevirapine.Approved
KetobemidoneThe metabolism of Ketobemidone can be increased when combined with Nevirapine.Approved
KetoconazoleThe serum concentration of Ketoconazole can be decreased when it is combined with Nevirapine.Approved, Investigational
KetoconazoleThe metabolism of Ketoconazole can be increased when combined with Nevirapine.Approved, Investigational
LabetalolThe metabolism of Labetalol can be decreased when combined with Nevirapine.Approved
LansoprazoleThe metabolism of Lansoprazole can be increased when combined with Nevirapine.Approved, Investigational
LapatinibThe serum concentration of Lapatinib can be decreased when it is combined with Nevirapine.Approved, Investigational
LaquinimodThe metabolism of Laquinimod can be increased when combined with Nevirapine.Investigational
LeflunomideThe metabolism of Leflunomide can be decreased when combined with Nevirapine.Approved, Investigational
LenvatinibThe metabolism of Lenvatinib can be increased when combined with Nevirapine.Approved
LercanidipineThe metabolism of Lercanidipine can be increased when combined with Nevirapine.Approved, Investigational
LetrozoleThe metabolism of Letrozole can be increased when combined with Nevirapine.Approved, Investigational
LevobupivacaineThe metabolism of Levobupivacaine can be increased when combined with Nevirapine.Approved
LevocetirizineThe metabolism of Levocetirizine can be increased when combined with Nevirapine.Approved
LevodopaThe metabolism of Levodopa can be decreased when combined with Nevirapine.Approved
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be increased when combined with Nevirapine.Approved
LevomilnacipranThe metabolism of Levomilnacipran can be increased when combined with Nevirapine.Approved
LevonorgestrelThe serum concentration of Levonorgestrel can be decreased when it is combined with Nevirapine.Approved, Investigational
LevothyroxineThe metabolism of Levothyroxine can be increased when combined with Nevirapine.Approved
LidocaineThe metabolism of Lidocaine can be increased when combined with Nevirapine.Approved, Vet Approved
LinagliptinThe serum concentration of Linagliptin can be decreased when it is combined with Nevirapine.Approved
LisurideThe metabolism of Lisuride can be increased when combined with Nevirapine.Approved
LomefloxacinThe metabolism of Lomefloxacin can be decreased when combined with Nevirapine.Approved
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Nevirapine.Approved
LomustineThe metabolism of Lomustine can be decreased when combined with Nevirapine.Approved
LoperamideThe metabolism of Loperamide can be increased when combined with Nevirapine.Approved
LopinavirThe serum concentration of Lopinavir can be decreased when it is combined with Nevirapine.Approved
LoratadineThe metabolism of Loratadine can be increased when combined with Nevirapine.Approved
LorcaserinThe metabolism of Lorcaserin can be increased when combined with Nevirapine.Approved
LosartanThe metabolism of Losartan can be increased when combined with Nevirapine.Approved
LovastatinThe metabolism of Lovastatin can be increased when combined with Nevirapine.Approved, Investigational
LuliconazoleThe serum concentration of Nevirapine can be increased when it is combined with Luliconazole.Approved
LumacaftorThe serum concentration of Nevirapine can be decreased when it is combined with Lumacaftor.Approved
LumefantrineThe serum concentration of Lumefantrine can be decreased when it is combined with Nevirapine.Approved
LumiracoxibThe metabolism of Lumiracoxib can be decreased when combined with Nevirapine.Approved, Investigational
LurasidoneThe serum concentration of Lurasidone can be decreased when it is combined with Nevirapine.Approved
LynestrenolThe serum concentration of Lynestrenol can be decreased when it is combined with Nevirapine.Investigational
MacitentanThe serum concentration of Macitentan can be decreased when it is combined with Nevirapine.Approved
MalathionThe metabolism of Malathion can be increased when combined with Nevirapine.Approved, Investigational
MaprotilineThe metabolism of Maprotiline can be decreased when combined with Nevirapine.Approved
MaravirocThe serum concentration of Maraviroc can be decreased when it is combined with Nevirapine.Approved, Investigational
ME-609The serum concentration of ME-609 can be decreased when it is combined with Nevirapine.Investigational
MebendazoleThe metabolism of Mebendazole can be increased when combined with Nevirapine.Approved, Vet Approved
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with Nevirapine.Approved, Investigational
MedrysoneThe serum concentration of Medrysone can be decreased when it is combined with Nevirapine.Approved
MefloquineThe metabolism of Mefloquine can be increased when combined with Nevirapine.Approved
MelatoninThe metabolism of Melatonin can be decreased when combined with Nevirapine.Approved, Nutraceutical, Vet Approved
MelengestrolThe serum concentration of Melengestrol can be decreased when it is combined with Nevirapine.Vet Approved
MeloxicamThe metabolism of Meloxicam can be increased when combined with Nevirapine.Approved, Vet Approved
MenadioneThe metabolism of Menadione can be decreased when combined with Nevirapine.Approved, Nutraceutical
MephenytoinThe metabolism of Mephenytoin can be increased when combined with Nevirapine.Investigational, Withdrawn
MequitazineThe metabolism of Mequitazine can be decreased when combined with Nevirapine.Approved
MesoridazineThe metabolism of Mesoridazine can be decreased when combined with Nevirapine.Approved
MestranolThe serum concentration of Mestranol can be decreased when it is combined with Nevirapine.Approved
MethadoneThe metabolism of Methadone can be increased when combined with Nevirapine.Approved
MethallenestrilThe serum concentration of Methallenestril can be decreased when it is combined with Nevirapine.Experimental
MethamphetamineThe metabolism of Methamphetamine can be decreased when combined with Nevirapine.Approved, Illicit
MethaqualoneThe metabolism of Methaqualone can be increased when combined with Nevirapine.Illicit, Withdrawn
MethotrimeprazineThe metabolism of Nevirapine can be decreased when combined with Methotrimeprazine.Approved
MethoxsalenThe metabolism of Methoxsalen can be increased when combined with Nevirapine.Approved
MethoxyfluraneThe metabolism of Methoxyflurane can be increased when combined with Nevirapine.Approved, Vet Approved
MethylphenidateThe metabolism of Methylphenidate can be decreased when combined with Nevirapine.Approved, Investigational
MethylphenobarbitalThe metabolism of Methylphenobarbital can be increased when combined with Nevirapine.Approved
MethylprednisoloneThe serum concentration of Methylprednisolone can be decreased when it is combined with Nevirapine.Approved, Vet Approved
MethyltestosteroneThe metabolism of Methyltestosterone can be increased when combined with Nevirapine.Approved
MethyprylonThe metabolism of Methyprylon can be decreased when combined with Nevirapine.Approved, Illicit, Withdrawn
MetoclopramideThe metabolism of Metoclopramide can be decreased when combined with Nevirapine.Approved, Investigational
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Nevirapine.Approved, Investigational
MetronidazoleThe metabolism of Metronidazole can be increased when combined with Nevirapine.Approved
MexiletineThe metabolism of Mexiletine can be increased when combined with Nevirapine.Approved
MianserinThe metabolism of Mianserin can be increased when combined with Nevirapine.Approved
MibefradilThe metabolism of Mibefradil can be increased when combined with Nevirapine.Withdrawn
MiconazoleThe metabolism of Miconazole can be increased when combined with Nevirapine.Approved, Investigational, Vet Approved
MidazolamThe metabolism of Midazolam can be increased when combined with Nevirapine.Approved, Illicit
MifepristoneThe serum concentration of Mifepristone can be decreased when it is combined with Nevirapine.Approved, Investigational
MinaprineThe metabolism of Minaprine can be decreased when combined with Nevirapine.Approved
MirabegronThe metabolism of Mirabegron can be increased when combined with Nevirapine.Approved
MirtazapineThe metabolism of Mirtazapine can be increased when combined with Nevirapine.Approved
MitotaneThe serum concentration of Nevirapine can be decreased when it is combined with Mitotane.Approved
MoclobemideThe metabolism of Moclobemide can be decreased when combined with Nevirapine.Approved
ModafinilThe metabolism of Modafinil can be increased when combined with Nevirapine.Approved, Investigational
MometasoneThe serum concentration of Mometasone can be decreased when it is combined with Nevirapine.Approved, Vet Approved
MontelukastThe metabolism of Montelukast can be increased when combined with Nevirapine.Approved
MorphineThe metabolism of Morphine can be increased when combined with Nevirapine.Approved, Investigational
muraglitazarThe metabolism of muraglitazar can be decreased when combined with Nevirapine.Investigational
Mycophenolate mofetilThe metabolism of Mycophenolate mofetil can be increased when combined with Nevirapine.Approved, Investigational
NabumetoneThe metabolism of Nabumetone can be decreased when combined with Nevirapine.Approved
NafcillinThe serum concentration of Nevirapine can be decreased when it is combined with Nafcillin.Approved
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Nevirapine.Approved
NaloxoneThe metabolism of Naloxone can be increased when combined with Nevirapine.Approved, Vet Approved
NaproxenThe metabolism of Naproxen can be decreased when combined with Nevirapine.Approved, Vet Approved
NateglinideThe metabolism of Nateglinide can be increased when combined with Nevirapine.Approved, Investigational
NCX 1022The serum concentration of NCX 1022 can be decreased when it is combined with Nevirapine.Investigational
NebivololThe serum concentration of Nebivolol can be increased when it is combined with Nevirapine.Approved, Investigational
NefazodoneThe metabolism of Nefazodone can be increased when combined with Nevirapine.Approved, Withdrawn
NelfinavirThe serum concentration of the active metabolites of Nelfinavir can be reduced when Nelfinavir is used in combination with Nevirapine resulting in a loss in efficacy.Approved
NetupitantThe serum concentration of Netupitant can be decreased when it is combined with Nevirapine.Approved
NicardipineThe metabolism of Nicardipine can be increased when combined with Nevirapine.Approved
NicergolineThe metabolism of Nicergoline can be decreased when combined with Nevirapine.Approved
NicotineThe metabolism of Nicotine can be increased when combined with Nevirapine.Approved
NifedipineThe serum concentration of Nifedipine can be decreased when it is combined with Nevirapine.Approved
NilotinibThe serum concentration of Nilotinib can be decreased when it is combined with Nevirapine.Approved, Investigational
NilvadipineThe metabolism of Nilvadipine can be increased when combined with Nevirapine.Approved
NimodipineThe serum concentration of Nimodipine can be decreased when it is combined with Nevirapine.Approved
NisoldipineThe serum concentration of Nisoldipine can be decreased when it is combined with Nevirapine.Approved
NitrazepamThe metabolism of Nitrazepam can be increased when combined with Nevirapine.Approved
NitrendipineThe metabolism of Nitrendipine can be increased when combined with Nevirapine.Approved
Nitric OxideThe metabolism of Nitric Oxide can be decreased when combined with Nevirapine.Approved
NitrofuralThe metabolism of Nitrofural can be decreased when combined with Nevirapine.Approved, Vet Approved
NorelgestrominThe serum concentration of Norelgestromin can be decreased when it is combined with Nevirapine.Approved
NorethisteroneThe metabolism of Norethisterone can be increased when combined with Nevirapine.Approved
NorgestimateThe serum concentration of Norgestimate can be decreased when it is combined with Nevirapine.Approved
NorgestrelThe serum concentration of Norgestrel can be decreased when it is combined with Nevirapine.Approved
NortriptylineThe metabolism of Nortriptyline can be increased when combined with Nevirapine.Approved
OlanzapineThe metabolism of Olanzapine can be decreased when combined with Nevirapine.Approved, Investigational
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Nevirapine.Approved
Oleoyl estroneThe serum concentration of Oleoyl estrone can be decreased when it is combined with Nevirapine.Investigational
OlopatadineThe metabolism of Olopatadine can be increased when combined with Nevirapine.Approved
OmeprazoleThe metabolism of Omeprazole can be increased when combined with Nevirapine.Approved, Investigational, Vet Approved
OndansetronThe metabolism of Ondansetron can be increased when combined with Nevirapine.Approved
OrphenadrineThe metabolism of Orphenadrine can be increased when combined with Nevirapine.Approved
OsimertinibThe serum concentration of Osimertinib can be decreased when it is combined with Nevirapine.Approved
OspemifeneThe metabolism of Ospemifene can be increased when combined with Nevirapine.Approved
OxaliplatinThe metabolism of Oxaliplatin can be decreased when combined with Nevirapine.Approved, Investigational
OxazepamThe metabolism of Oxazepam can be increased when combined with Nevirapine.Approved
OxtriphyllineThe metabolism of Oxtriphylline can be decreased when combined with Nevirapine.Approved
OxybutyninThe metabolism of Oxybutynin can be increased when combined with Nevirapine.Approved, Investigational
OxycodoneThe risk or severity of adverse effects can be increased when Nevirapine is combined with Oxycodone.Approved, Illicit, Investigational
OxymorphoneThe metabolism of Oxymorphone can be increased when combined with Nevirapine.Approved, Investigational, Vet Approved
PaclitaxelThe metabolism of Paclitaxel can be increased when combined with Nevirapine.Approved, Vet Approved
PalbociclibThe serum concentration of Palbociclib can be decreased when it is combined with Nevirapine.Approved
PalonosetronThe metabolism of Palonosetron can be increased when combined with Nevirapine.Approved, Investigational
PanobinostatThe serum concentration of Panobinostat can be decreased when it is combined with Nevirapine.Approved, Investigational
PantoprazoleThe metabolism of Pantoprazole can be increased when combined with Nevirapine.Approved
ParamethadioneThe metabolism of Paramethadione can be increased when combined with Nevirapine.Approved
ParamethasoneThe metabolism of Paramethasone can be increased when combined with Nevirapine.Approved
ParecoxibThe metabolism of Parecoxib can be increased when combined with Nevirapine.Approved
ParicalcitolThe metabolism of Paricalcitol can be increased when combined with Nevirapine.Approved, Investigational
ParitaprevirThe metabolism of Paritaprevir can be increased when combined with Nevirapine.Approved
ParoxetineThe metabolism of Nevirapine can be decreased when combined with Paroxetine.Approved, Investigational
PazopanibThe serum concentration of Pazopanib can be decreased when it is combined with Nevirapine.Approved
Peginterferon alfa-2bThe serum concentration of Nevirapine can be decreased when it is combined with Peginterferon alfa-2b.Approved
PentamidineThe metabolism of Pentamidine can be increased when combined with Nevirapine.Approved
PentobarbitalThe metabolism of Nevirapine can be increased when combined with Pentobarbital.Approved, Vet Approved
PentoxifyllineThe metabolism of Pentoxifylline can be decreased when combined with Nevirapine.Approved, Investigational
PerampanelThe serum concentration of Perampanel can be decreased when it is combined with Nevirapine.Approved
PergolideThe metabolism of Pergolide can be increased when combined with Nevirapine.Approved, Vet Approved, Withdrawn
PerhexilineThe metabolism of Perhexiline can be increased when combined with Nevirapine.Approved
PermethrinThe metabolism of Permethrin can be increased when combined with Nevirapine.Approved, Investigational
PerphenazineThe metabolism of Perphenazine can be increased when combined with Nevirapine.Approved
PethidineThe metabolism of Pethidine can be increased when combined with Nevirapine.Approved
PhenacetinThe metabolism of Phenacetin can be increased when combined with Nevirapine.Withdrawn
PhenforminThe metabolism of Phenformin can be decreased when combined with Nevirapine.Approved, Withdrawn
PhenobarbitalThe metabolism of Nevirapine can be increased when combined with Phenobarbital.Approved
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be increased when combined with Nevirapine.Approved
PhenprocoumonThe metabolism of Phenprocoumon can be increased when combined with Nevirapine.Approved
PhenytoinThe metabolism of Phenytoin can be increased when combined with Nevirapine.Approved, Vet Approved
PilocarpineThe metabolism of Pilocarpine can be increased when combined with Nevirapine.Approved
PimecrolimusThe metabolism of Pimecrolimus can be decreased when combined with Nevirapine.Approved, Investigational
PimozideThe serum concentration of Pimozide can be increased when it is combined with Nevirapine.Approved
PinacidilThe metabolism of Pinacidil can be increased when combined with Nevirapine.Withdrawn
PindololThe metabolism of Pindolol can be decreased when combined with Nevirapine.Approved
PioglitazoneThe metabolism of Pioglitazone can be increased when combined with Nevirapine.Approved, Investigational
PiperazineThe metabolism of Piperazine can be decreased when combined with Nevirapine.Approved, Vet Approved
PipotiazineThe metabolism of Pipotiazine can be increased when combined with Nevirapine.Approved
PirfenidoneThe serum concentration of Pirfenidone can be increased when it is combined with Nevirapine.Investigational
PodofiloxThe metabolism of Podofilox can be increased when combined with Nevirapine.Approved
PomalidomideThe metabolism of Pomalidomide can be increased when combined with Nevirapine.Approved
PonatinibThe serum concentration of Ponatinib can be decreased when it is combined with Nevirapine.Approved
PosaconazoleThe metabolism of Posaconazole can be increased when combined with Nevirapine.Approved, Investigational, Vet Approved
PrasteroneThe metabolism of Prasterone can be increased when combined with Nevirapine.Approved, Nutraceutical
PrasugrelThe metabolism of Prasugrel can be increased when combined with Nevirapine.Approved
PravastatinThe metabolism of Pravastatin can be increased when combined with Nevirapine.Approved
PrazepamThe metabolism of Prazepam can be increased when combined with Nevirapine.Approved, Illicit
PraziquantelThe serum concentration of Praziquantel can be decreased when it is combined with Nevirapine.Approved, Vet Approved
PrednicarbateThe serum concentration of Prednicarbate can be decreased when it is combined with Nevirapine.Approved
PrednisoloneThe metabolism of Prednisolone can be increased when combined with Nevirapine.Approved, Vet Approved
PrednisoloneThe serum concentration of Prednisolone can be decreased when it is combined with Nevirapine.Approved, Vet Approved
PrednisoneThe serum concentration of Prednisone can be decreased when it is combined with Nevirapine.Approved, Vet Approved
PregnenoloneThe serum concentration of Pregnenolone can be decreased when it is combined with Nevirapine.Experimental
PrimaquineThe metabolism of Primaquine can be increased when combined with Nevirapine.Approved
PrimidoneThe metabolism of Nevirapine can be increased when combined with Primidone.Approved, Vet Approved
ProcainamideThe metabolism of Procainamide can be decreased when combined with Nevirapine.Approved
ProchlorperazineThe metabolism of Prochlorperazine can be increased when combined with Nevirapine.Approved, Vet Approved
ProgesteroneThe metabolism of Progesterone can be increased when combined with Nevirapine.Approved, Vet Approved
ProguanilThe metabolism of Proguanil can be increased when combined with Nevirapine.Approved
PromazineThe metabolism of Promazine can be increased when combined with Nevirapine.Approved, Vet Approved
PromethazineThe metabolism of Promethazine can be increased when combined with Nevirapine.Approved
PropafenoneThe serum concentration of Nevirapine can be increased when it is combined with Propafenone.Approved
PropofolThe metabolism of Propofol can be increased when combined with Nevirapine.Approved, Investigational, Vet Approved
PropranololThe metabolism of Propranolol can be increased when combined with Nevirapine.Approved, Investigational
ProtriptylineThe metabolism of Protriptyline can be decreased when combined with Nevirapine.Approved
PseudoephedrineThe metabolism of Pseudoephedrine can be decreased when combined with Nevirapine.Approved
PyrazinamideThe metabolism of Pyrazinamide can be increased when combined with Nevirapine.Approved
PyrimethamineThe metabolism of Nevirapine can be decreased when combined with Pyrimethamine.Approved, Vet Approved
QuazepamThe serum concentration of Nevirapine can be increased when it is combined with Quazepam.Approved, Illicit
QuetiapineThe serum concentration of Quetiapine can be decreased when it is combined with Nevirapine.Approved
QuinacrineThe metabolism of Quinacrine can be increased when combined with Nevirapine.Approved
QuinidineThe metabolism of Quinidine can be increased when combined with Nevirapine.Approved
QuinineThe metabolism of Quinine can be increased when combined with Nevirapine.Approved
RabeprazoleThe metabolism of Rabeprazole can be increased when combined with Nevirapine.Approved, Investigational
RaloxifeneThe metabolism of Raloxifene can be increased when combined with Nevirapine.Approved, Investigational
RamelteonThe metabolism of Ramelteon can be increased when combined with Nevirapine.Approved, Investigational
RanitidineThe metabolism of Ranitidine can be decreased when combined with Nevirapine.Approved
RanolazineThe serum concentration of Ranolazine can be decreased when it is combined with Nevirapine.Approved, Investigational
RasagilineThe metabolism of Rasagiline can be decreased when combined with Nevirapine.Approved
ReboxetineThe metabolism of Reboxetine can be increased when combined with Nevirapine.Approved, Investigational
RegorafenibThe serum concentration of Regorafenib can be decreased when it is combined with Nevirapine.Approved
RemoxiprideThe metabolism of Remoxipride can be decreased when combined with Nevirapine.Approved, Withdrawn
RepaglinideThe metabolism of Repaglinide can be increased when combined with Nevirapine.Approved, Investigational
repinotanThe metabolism of repinotan can be decreased when combined with Nevirapine.Investigational
ResveratrolThe metabolism of Resveratrol can be decreased when combined with Nevirapine.Experimental, Investigational
RetapamulinThe metabolism of Retapamulin can be increased when combined with Nevirapine.Approved
RifabutinThe serum concentration of Nevirapine can be decreased when it is combined with Rifabutin.Approved
RifampicinThe serum concentration of Nevirapine can be decreased when it is combined with Rifampicin.Approved
RifapentineThe metabolism of Nevirapine can be increased when combined with Rifapentine.Approved
RilpivirineThe serum concentration of Rilpivirine can be increased when it is combined with Nevirapine.Approved
RiluzoleThe metabolism of Riluzole can be decreased when combined with Nevirapine.Approved, Investigational
RimexoloneThe serum concentration of Rimexolone can be decreased when it is combined with Nevirapine.Approved
RimonabantThe metabolism of Rimonabant can be increased when combined with Nevirapine.Approved, Investigational
RiociguatThe metabolism of Riociguat can be increased when combined with Nevirapine.Approved
RisperidoneThe metabolism of Risperidone can be increased when combined with Nevirapine.Approved, Investigational
RitonavirThe metabolism of Ritonavir can be increased when combined with Nevirapine.Approved, Investigational
RivaroxabanThe serum concentration of Rivaroxaban can be decreased when it is combined with Nevirapine.Approved
RizatriptanThe metabolism of Rizatriptan can be decreased when combined with Nevirapine.Approved
RofecoxibThe metabolism of Rofecoxib can be increased when combined with Nevirapine.Investigational, Withdrawn
RoflumilastThe serum concentration of Roflumilast can be decreased when it is combined with Nevirapine.Approved
RolapitantThe serum concentration of Rolapitant can be decreased when it is combined with Nevirapine.Approved
RomidepsinThe serum concentration of Romidepsin can be decreased when it is combined with Nevirapine.Approved, Investigational
RopiniroleThe metabolism of Ropinirole can be increased when combined with Nevirapine.Approved, Investigational
RopivacaineThe metabolism of Ropivacaine can be increased when combined with Nevirapine.Approved
RosuvastatinThe metabolism of Rosuvastatin can be increased when combined with Nevirapine.Approved
RotigotineThe metabolism of Rotigotine can be increased when combined with Nevirapine.Approved
RoxithromycinThe metabolism of Roxithromycin can be increased when combined with Nevirapine.Approved, Withdrawn
RuxolitinibThe metabolism of Ruxolitinib can be increased when combined with Nevirapine.Approved
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Nevirapine.Approved
SaquinavirThe serum concentration of Saquinavir can be decreased when it is combined with Nevirapine.Approved, Investigational
SaxagliptinThe serum concentration of Saxagliptin can be decreased when it is combined with Nevirapine.Approved
SecobarbitalThe metabolism of Nevirapine can be increased when combined with Secobarbital.Approved, Vet Approved
SelegilineThe metabolism of Selegiline can be increased when combined with Nevirapine.Approved, Investigational, Vet Approved
SelexipagThe metabolism of Selexipag can be increased when combined with Nevirapine.Approved
SeratrodastThe metabolism of Seratrodast can be increased when combined with Nevirapine.Approved, Investigational
SertindoleThe metabolism of Sertindole can be increased when combined with Nevirapine.Approved, Withdrawn
SertralineThe metabolism of Sertraline can be increased when combined with Nevirapine.Approved
SevofluraneThe metabolism of Sevoflurane can be increased when combined with Nevirapine.Approved, Vet Approved
SibutramineThe metabolism of Sibutramine can be increased when combined with Nevirapine.Approved, Illicit, Investigational, Withdrawn
SildenafilThe metabolism of Sildenafil can be increased when combined with Nevirapine.Approved, Investigational
SilodosinThe metabolism of Silodosin can be increased when combined with Nevirapine.Approved
SiltuximabThe serum concentration of Nevirapine can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with Nevirapine.Approved
SimvastatinThe metabolism of Simvastatin can be increased when combined with Nevirapine.Approved
SirolimusThe metabolism of Sirolimus can be increased when combined with Nevirapine.Approved, Investigational
SitagliptinThe metabolism of Sitagliptin can be increased when combined with Nevirapine.Approved, Investigational
SolifenacinThe metabolism of Solifenacin can be increased when combined with Nevirapine.Approved
SonidegibThe serum concentration of Sonidegib can be decreased when it is combined with Nevirapine.Approved, Investigational
SorafenibThe serum concentration of Sorafenib can be decreased when it is combined with Nevirapine.Approved, Investigational
SparteineThe metabolism of Sparteine can be decreased when combined with Nevirapine.Experimental
SpiramycinThe metabolism of Spiramycin can be increased when combined with Nevirapine.Approved
St. John's WortThe serum concentration of Nevirapine can be decreased when it is combined with St. John&#39;s Wort.Nutraceutical
StiripentolThe serum concentration of Nevirapine can be increased when it is combined with Stiripentol.Approved
SufentanilThe metabolism of Sufentanil can be increased when combined with Nevirapine.Approved, Investigational
SulfadiazineThe metabolism of Sulfadiazine can be increased when combined with Nevirapine.Approved, Vet Approved
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be increased when combined with Nevirapine.Approved
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be increased when combined with Nevirapine.Approved
SulfisoxazoleThe metabolism of Nevirapine can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
SunitinibThe serum concentration of Sunitinib can be decreased when it is combined with Nevirapine.Approved, Investigational
SuvorexantThe serum concentration of Suvorexant can be decreased when it is combined with Nevirapine.Approved
Synthetic Conjugated Estrogens, AThe serum concentration of Synthetic Conjugated Estrogens, A can be decreased when it is combined with Nevirapine.Approved
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be increased when combined with Nevirapine.Approved
TacrineThe metabolism of Tacrine can be decreased when combined with Nevirapine.Withdrawn
TacrolimusThe metabolism of Tacrolimus can be increased when combined with Nevirapine.Approved, Investigational
TadalafilThe serum concentration of Tadalafil can be decreased when it is combined with Nevirapine.Approved, Investigational
TamoxifenThe serum concentration of the active metabolites of Tamoxifen can be reduced when Tamoxifen is used in combination with Nevirapine resulting in a loss in efficacy.Approved
TamsulosinThe metabolism of Tamsulosin can be increased when combined with Nevirapine.Approved, Investigational
TapentadolThe metabolism of Tapentadol can be decreased when combined with Nevirapine.Approved
TasimelteonThe serum concentration of Tasimelteon can be decreased when it is combined with Nevirapine.Approved
TasosartanThe metabolism of Tasosartan can be increased when combined with Nevirapine.Approved
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be increased when combined with Nevirapine.Experimental
TegaserodThe metabolism of Tegaserod can be decreased when combined with Nevirapine.Investigational, Withdrawn
TelaprevirThe serum concentration of Telaprevir can be decreased when it is combined with Nevirapine.Approved
TelithromycinThe metabolism of Telithromycin can be increased when combined with Nevirapine.Approved
TemafloxacinThe metabolism of Temafloxacin can be decreased when combined with Nevirapine.Withdrawn
TemazepamThe metabolism of Temazepam can be increased when combined with Nevirapine.Approved
TemsirolimusThe metabolism of Temsirolimus can be increased when combined with Nevirapine.Approved
TeniposideThe metabolism of Teniposide can be increased when combined with Nevirapine.Approved
TerbinafineThe metabolism of Terbinafine can be increased when combined with Nevirapine.Approved, Investigational, Vet Approved
TerfenadineThe metabolism of Terfenadine can be increased when combined with Nevirapine.Withdrawn
TesmilifeneThe metabolism of Tesmilifene can be increased when combined with Nevirapine.Investigational
TestosteroneThe metabolism of Testosterone can be increased when combined with Nevirapine.Approved, Investigational
TetrabenazineThe metabolism of Tetrabenazine can be decreased when combined with Nevirapine.Approved
TetracyclineThe metabolism of Tetracycline can be increased when combined with Nevirapine.Approved, Vet Approved
ThalidomideThe metabolism of Thalidomide can be decreased when combined with Nevirapine.Approved, Investigational, Withdrawn
TheobromineThe metabolism of Theobromine can be decreased when combined with Nevirapine.Approved
TheophyllineThe metabolism of Theophylline can be increased when combined with Nevirapine.Approved
ThiabendazoleThe metabolism of Thiabendazole can be decreased when combined with Nevirapine.Approved, Vet Approved
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Nevirapine.Approved
ThiotepaThe metabolism of Thiotepa can be increased when combined with Nevirapine.Approved
ThiothixeneThe metabolism of Thiothixene can be decreased when combined with Nevirapine.Approved
TiagabineThe metabolism of Tiagabine can be increased when combined with Nevirapine.Approved
TicagrelorThe serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with Nevirapine resulting in a loss in efficacy.Approved
TiclopidineThe metabolism of Ticlopidine can be increased when combined with Nevirapine.Approved
TimololThe metabolism of Timolol can be decreased when combined with Nevirapine.Approved
TinidazoleThe metabolism of Tinidazole can be increased when combined with Nevirapine.Approved, Investigational
TiotropiumThe metabolism of Tiotropium can be increased when combined with Nevirapine.Approved
TipranavirThe metabolism of Tipranavir can be increased when combined with Nevirapine.Approved, Investigational
TixocortolThe serum concentration of Tixocortol can be decreased when it is combined with Nevirapine.Approved
TizanidineThe serum concentration of Tizanidine can be increased when it is combined with Nevirapine.Approved
TocilizumabThe serum concentration of Nevirapine can be decreased when it is combined with Tocilizumab.Approved
TofacitinibThe serum concentration of Tofacitinib can be decreased when it is combined with Nevirapine.Approved, Investigational
TolbutamideThe metabolism of Nevirapine can be decreased when combined with Tolbutamide.Approved
TolterodineThe metabolism of Tolterodine can be increased when combined with Nevirapine.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be decreased when it is combined with Nevirapine.Approved
ToremifeneThe serum concentration of Toremifene can be decreased when it is combined with Nevirapine.Approved, Investigational
TrabectedinThe serum concentration of Trabectedin can be decreased when it is combined with Nevirapine.Approved, Investigational
TramadolThe therapeutic efficacy of Tramadol can be decreased when used in combination with Nevirapine.Approved, Investigational
TranylcypromineThe metabolism of Nevirapine can be decreased when combined with Tranylcypromine.Approved
Trastuzumab emtansineThe metabolism of Trastuzumab emtansine can be increased when combined with Nevirapine.Approved
TrazodoneThe metabolism of Trazodone can be increased when combined with Nevirapine.Approved, Investigational
TretinoinThe metabolism of Tretinoin can be increased when combined with Nevirapine.Approved, Investigational, Nutraceutical
TriamcinoloneThe metabolism of Triamcinolone can be increased when combined with Nevirapine.Approved, Vet Approved
TriamtereneThe metabolism of Triamterene can be decreased when combined with Nevirapine.Approved
TriazolamThe metabolism of Triazolam can be increased when combined with Nevirapine.Approved
TrifluoperazineThe metabolism of Trifluoperazine can be decreased when combined with Nevirapine.Approved
TrimethadioneThe metabolism of Trimethadione can be increased when combined with Nevirapine.Approved
TrimethoprimThe metabolism of Trimethoprim can be increased when combined with Nevirapine.Approved, Vet Approved
TrimipramineThe metabolism of Trimipramine can be increased when combined with Nevirapine.Approved
TroglitazoneThe metabolism of Troglitazone can be increased when combined with Nevirapine.Withdrawn
TroleandomycinThe metabolism of Troleandomycin can be increased when combined with Nevirapine.Approved
UdenafilThe metabolism of Udenafil can be increased when combined with Nevirapine.Approved, Investigational
UlipristalThe serum concentration of Ulipristal can be decreased when it is combined with Nevirapine.Approved
UmeclidiniumThe metabolism of Umeclidinium can be decreased when combined with Nevirapine.Approved
ValdecoxibThe metabolism of Valdecoxib can be increased when combined with Nevirapine.Investigational, Withdrawn
Valproic AcidThe metabolism of Valproic Acid can be increased when combined with Nevirapine.Approved, Investigational
ValsartanThe metabolism of Nevirapine can be decreased when combined with Valsartan.Approved, Investigational
VandetanibThe serum concentration of Vandetanib can be decreased when it is combined with Nevirapine.Approved
VanoxerineThe metabolism of Vanoxerine can be increased when combined with Nevirapine.Investigational
VardenafilThe metabolism of Vardenafil can be increased when combined with Nevirapine.Approved
VemurafenibThe serum concentration of Vemurafenib can be decreased when it is combined with Nevirapine.Approved
VenetoclaxThe metabolism of Venetoclax can be increased when combined with Nevirapine.Approved
VenlafaxineThe metabolism of Venlafaxine can be increased when combined with Nevirapine.Approved
VerapamilThe metabolism of Verapamil can be increased when combined with Nevirapine.Approved
VicrivirocThe metabolism of Vicriviroc can be increased when combined with Nevirapine.Investigational
VilanterolThe metabolism of Vilanterol can be increased when combined with Nevirapine.Approved
VilazodoneThe serum concentration of Vilazodone can be decreased when it is combined with Nevirapine.Approved
VinblastineThe metabolism of Vinblastine can be increased when combined with Nevirapine.Approved
VincristineThe serum concentration of Vincristine can be decreased when it is combined with Nevirapine.Approved, Investigational
VincristineThe metabolism of Vincristine can be increased when combined with Nevirapine.Approved, Investigational
VindesineThe serum concentration of Vindesine can be increased when it is combined with Nevirapine.Approved
VinorelbineThe metabolism of Vinorelbine can be increased when combined with Nevirapine.Approved, Investigational
VismodegibThe metabolism of Vismodegib can be increased when combined with Nevirapine.Approved
VorapaxarThe serum concentration of Vorapaxar can be decreased when it is combined with Nevirapine.Approved
VoriconazoleThe serum concentration of Voriconazole can be decreased when it is combined with Nevirapine.Approved, Investigational
VortioxetineThe serum concentration of Vortioxetine can be decreased when it is combined with Nevirapine.Approved
WarfarinThe metabolism of Warfarin can be increased when combined with Nevirapine.Approved
YohimbineThe metabolism of Yohimbine can be increased when combined with Nevirapine.Approved, Vet Approved
ZafirlukastThe metabolism of Zafirlukast can be increased when combined with Nevirapine.Approved, Investigational
ZalcitabineThe metabolism of Zalcitabine can be increased when combined with Nevirapine.Approved
ZaleplonThe serum concentration of Zaleplon can be decreased when it is combined with Nevirapine.Approved, Illicit, Investigational
ZidovudineThe metabolism of Zidovudine can be increased when combined with Nevirapine.Approved
ZileutonThe metabolism of Zileuton can be increased when combined with Nevirapine.Approved, Investigational, Withdrawn
ZiprasidoneThe metabolism of Ziprasidone can be increased when combined with Nevirapine.Approved
ZolmitriptanThe metabolism of Zolmitriptan can be decreased when combined with Nevirapine.Approved, Investigational
ZolpidemThe metabolism of Zolpidem can be increased when combined with Nevirapine.Approved
ZomepiracThe metabolism of Zomepirac can be increased when combined with Nevirapine.Withdrawn
ZonisamideThe metabolism of Zonisamide can be increased when combined with Nevirapine.Approved, Investigational
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Nevirapine.Approved
ZuclopenthixolThe serum concentration of Zuclopenthixol can be decreased when it is combined with Nevirapine.Approved, Investigational
Food Interactions
  • Avoid alcohol.
  • Take without regard to meals.
References
Synthesis Reference

DrugSyn.org

US5366972
General ReferencesNot Available
External Links
ATC CodesJ05AR05J05AG01J05AR07
AHFS Codes
  • 08:18.08.16
PDB EntriesNot Available
FDA labelDownload (423 KB)
MSDSDownload (57 KB)
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9958
Blood Brain Barrier+0.9756
Caco-2 permeable+0.8867
P-glycoprotein substrateNon-substrate0.5606
P-glycoprotein inhibitor INon-inhibitor0.6488
P-glycoprotein inhibitor IINon-inhibitor0.8514
Renal organic cation transporterNon-inhibitor0.7124
CYP450 2C9 substrateNon-substrate0.6179
CYP450 2D6 substrateSubstrate0.8919
CYP450 3A4 substrateSubstrate0.6413
CYP450 1A2 substrateInhibitor0.6175
CYP450 2C9 inhibitorNon-inhibitor0.8009
CYP450 2D6 inhibitorNon-inhibitor0.9451
CYP450 2C19 inhibitorNon-inhibitor0.7971
CYP450 3A4 inhibitorNon-inhibitor0.8309
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.5443
Ames testAMES toxic0.5952
CarcinogenicityNon-carcinogens0.9383
BiodegradationNot ready biodegradable0.964
Rat acute toxicity2.6729 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9827
hERG inhibition (predictor II)Non-inhibitor0.8321
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Boehringer ingelheim pharmaceuticals inc
Packagers
Dosage forms
FormRouteStrength
TabletOral
SuspensionOral50 mg/5mL
TabletOral200 mg/1
Tablet, coatedOral200 mg/1
Tablet, extended releaseOral100 mg/1
Tablet, extended releaseOral400 mg/1
TabletOral400 mg/1
TabletOral200 mg
Tablet, extended releaseOral100 mg
Tablet, extended releaseOral50 mg
Tablet, extended releaseOral400 mg
Prices
Unit descriptionCostUnit
Viramune 200 mg tablet9.3USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2030056 No1995-10-172010-11-15Canada
US5366972 No1995-05-222012-05-22Us
US8460704 No2009-03-122029-03-12Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point196.06Not Available
water solubility0.7046 mg/LNot Available
logP2.5Not Available
Caco2 permeability-4.52ADME Research, USCD
Predicted Properties
PropertyValueSource
Water Solubility0.105 mg/mLALOGPS
logP1.75ALOGPS
logP2.49ChemAxon
logS-3.4ALOGPS
pKa (Strongest Acidic)10.37ChemAxon
pKa (Strongest Basic)5.06ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area58.12 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity77.48 m3·mol-1ChemAxon
Polarizability27.8 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as alkyldiarylamines. These are tertiary alkylarylamines having two aryl and one alkyl groups attached to the amino group.
KingdomOrganic compounds
Super ClassOrganonitrogen compounds
ClassAmines
Sub ClassTertiary amines
Direct ParentAlkyldiarylamines
Alternative Parents
Substituents
  • Alkyldiarylamine
  • Pyrido-para-diazepine
  • Methylpyridine
  • Para-diazepine
  • Imidolactam
  • Pyridine
  • Heteroaromatic compound
  • Vinylogous amide
  • Secondary carboxylic acid amide
  • Lactam
  • Carboxamide group
  • Azacycle
  • Organoheterocyclic compound
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organooxygen compound
  • Carbonyl group
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors

Targets

Kind
Protein
Organism
Human immunodeficiency virus 1
Pharmacological action
yes
Actions
inhibitor
General Function:
Rna-dna hybrid ribonuclease activity
Specific Function:
Not Available
Gene Name:
pol
Uniprot ID:
Q72547
Molecular Weight:
65223.615 Da
References
  1. Ambrose Z, Herman BD, Sheen CW, Zelina S, Moore KL, Tachedjian G, Nissley DV, Sluis-Cremer N: The human immunodeficiency virus type 1 nonnucleoside reverse transcriptase inhibitor resistance mutation I132M confers hypersensitivity to nucleoside analogs. J Virol. 2009 Apr;83(8):3826-33. doi: 10.1128/JVI.01968-08. Epub 2009 Feb 4. [PubMed:19193782 ]
  2. Nikolenko GN, Delviks-Frankenberry KA, Pathak VK: A novel molecular mechanism of dual resistance to nucleoside and nonnucleoside reverse transcriptase inhibitors. J Virol. 2010 May;84(10):5238-49. doi: 10.1128/JVI.01545-09. Epub 2010 Mar 10. [PubMed:20219933 ]
  3. Ghosn J, Chaix ML, Delaugerre C: HIV-1 resistance to first- and second-generation non-nucleoside reverse transcriptase inhibitors. AIDS Rev. 2009 Jul-Sep;11(3):165-73. [PubMed:19654858 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitorinducer
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinducer
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Gene Name:
CYP2B6
Uniprot ID:
P20813
Molecular Weight:
56277.81 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A5
Uniprot ID:
P20815
Molecular Weight:
57108.065 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity.
Gene Name:
CYP2A6
Uniprot ID:
P11509
Molecular Weight:
56501.005 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Comments
comments powered by Disqus
Drug created on June 13, 2005 07:24 / Updated on December 03, 2016 02:46