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Identification
NameEtravirine
Accession NumberDB06414
TypeSmall Molecule
GroupsApproved
DescriptionEtravirine is an antiretroviral agent more specifically classified as a Non-Nucleoside Reverse Transcriptase Inhibitor(NNRTI). Etraverine is used clinically for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. On January 18, 2007, the FDA granted accelerated approved for the use of etravirine 100mg tablets in the treatment of adult HIV-1 infection documented to be resistant to therapy with other NNRTIs and antiretroviral agents. On March 26, 2012, approval was extended for use in treatment-experienced pediatric patients 6 to 18 years of age, weighing at least 16 kg. Etravarine must always be used in combination with other antiretroviral drugs. Etravirine exerts its effects via direct inhibition of the reverse transcriptase enzyme of human immunodeficiency virus type 1 (HIV-1), and consequently blocks DNA-dependent and RNA-dependent polymerase activity. Etravirine does not inhibit human DNA polymerase alpha, beta or gamma. Common side effects of use include mild to moderate rash within the first 6 weeks of therapy, nausea, diarrhea and peripheral neuropathy. Patients are advised to immediately contact their healthcare provider if a rash develops. In 2009, postmarketing case reports of Stevens-Johnson Syndrome, toxic epidermal necrolysis, erythema multiforme, and other hypersensitivity reactions lead to a revision of etravirine's "Warnings and Precautions," as well as notification of health care providers. In 2013, reports of Autoimmune disorders (such as Graves’ disease, polymyositis, and Guillain-Barré syndrome) in the setting of immune reconstitution, as well as more in depth information about the development of rashes in patients taking etravirine, lead to a modification of etravirine's monograph.
Structure
Thumb
Synonyms
Intelence
External Identifiers
  • R165335
  • TMC125
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
IntelenceTablet100 mgOralJanssen Inc2008-03-27Not applicableCanada
IntelenceTablet100 mg/1OralREMEDYREPACK INC.2013-03-182016-04-05Us
IntelenceTablet200 mgOralJanssen Cilag International Nv2008-08-28Not applicableEu
IntelenceTablet100 mg/1OralJanssen Products LP2008-01-18Not applicableUs
IntelenceTablet200 mgOralJanssen Inc2011-12-12Not applicableCanada
IntelenceTablet100 mg/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
IntelenceTablet25 mgOralJanssen Cilag International Nv2008-08-28Not applicableEu
IntelenceTablet200 mg/1OralJanssen Products LP2010-12-22Not applicableUs
IntelenceTablet25 mgOralJanssen Inc2013-06-14Not applicableCanada
IntelenceTablet100 mg/1OralPhysicians Total Care, Inc.2008-02-21Not applicableUs
IntelenceTablet100 mg/1OralA S Medication Solutions2008-01-18Not applicableUs
IntelenceTablet25 mg/1OralJanssen Products LP2012-03-26Not applicableUs
IntelenceTablet100 mgOralJanssen Cilag International Nv2008-08-28Not applicableEu
IntelenceTablet200 mg/1OralPhysicians Total Care, Inc.2012-10-10Not applicableUs
IntelenceTablet200 mg/1OralA S Medication Solutions2010-12-22Not applicableUs
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
SaltsNot Available
Categories
UNII0C50HW4FO1
CAS number269055-15-4
WeightAverage: 435.277
Monoisotopic: 434.049071779
Chemical FormulaC20H15BrN6O
InChI KeyPYGWGZALEOIKDF-UHFFFAOYSA-N
InChI
InChI=1S/C20H15BrN6O/c1-11-7-14(10-23)8-12(2)17(11)28-19-16(21)18(24)26-20(27-19)25-15-5-3-13(9-22)4-6-15/h3-8H,1-2H3,(H3,24,25,26,27)
IUPAC Name
4-({6-amino-5-bromo-2-[(4-cyanophenyl)amino]pyrimidin-4-yl}oxy)-3,5-dimethylbenzonitrile
SMILES
CC1=CC(=CC(C)=C1OC1=C(Br)C(N)=NC(NC2=CC=C(C=C2)C#N)=N1)C#N
Pharmacology
IndicationIndicated as an adjunct therapy in the treatment of adult HIV-1 infections resistant to therapy with other NNRTIs and antiretroviral agents.
Structured Indications
PharmacodynamicsClinical trials have shown no prolongation of QT intervals on electrocardiograms after 8 days of dosing.
Mechanism of actionEtravirine exerts its effects via direct inhibition of the reverse transcriptase enzyme of human immunodeficiency virus type 1 (HIV-1). It directly binds reverse transcriptase and consequently blocks DNA-dependent and RNA-dependent polymerase activity. Etravirine does not inhibit human DNA polymerase alpha, beta or gamma.
Related Articles
AbsorptionMaximum oral absorption is achieved in 2.5-4 hours. Absorption is unaffected by the concomitant use of oral ranitidine or omeprazole, which decrease gastric acidity. Administration under fasting conditions resulted in a near 50% decrease in systemic exposure (AUC) when compared to administration after a meal.
Volume of distribution

Distribution of etravirine into compartments other than plasma has not been evaluated in humans.

Protein bindingPlasma protein binding is about 99.9% in vitro. In vitro, 99.6% is bound to albumin, and 97.66% - 99.02% is bound to 1-alpha glycoprotein.
Metabolism

Metabolized (in vitro) by the liver CYP450 enzymes: CYP3A4, CYP2C9, CYP2C19. The major metabolites formed by a methyl hydroxylation of the dimethylbenzonitrile moiety retained less than 90% of etravirine's activity.

Route of eliminationAfter a 800mg dose of radio-labelled etraverine, 93.7% was found to undergo fecal elimination, with 81.2% - 86.4% eliminated unchanged. 1.2% of the dose was renally eliminated, changed. Etravirine is dialyzable (hemodialysis).
Half lifeHalf life of 9.05-41 hours.
Clearance

Renal clearance of etravirine is negligible (<1.2%), thus no dose adjustments are required in patients with renal impairment.

Clearance is shown to be reduced in patients with Hepatitis B and/or co-infection, however, the safety profile of etravirine does not call for dosage adjustments.

ToxicityNot Available
Affected organismsNot Available
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
1,10-PhenanthrolineThe serum concentration of Etravirine can be decreased when it is combined with 1,10-Phenanthroline.Experimental
2-HYDROXY-1,4-NAPHTHOQUINONEThe serum concentration of Etravirine can be increased when it is combined with 2-HYDROXY-1,4-NAPHTHOQUINONE.Experimental
2-mercaptobenzothiazoleThe serum concentration of Etravirine can be increased when it is combined with 2-mercaptobenzothiazole.Vet Approved
3,4-DichloroisocoumarinThe serum concentration of Etravirine can be decreased when it is combined with 3,4-Dichloroisocoumarin.Experimental
4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDEThe serum concentration of Etravirine can be decreased when it is combined with 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE.Experimental
AbirateroneThe serum concentration of Abiraterone can be decreased when it is combined with Etravirine.Approved
AcebutololThe serum concentration of Acebutolol can be increased when it is combined with Etravirine.Approved
AceclofenacThe metabolism of Aceclofenac can be decreased when combined with Etravirine.Approved
AcenocoumarolThe serum concentration of Acenocoumarol can be decreased when it is combined with Etravirine.Approved
AcetaminophenThe serum concentration of Acetaminophen can be decreased when it is combined with Etravirine.Approved
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Etravirine.Approved, Vet Approved
AdinazolamThe serum concentration of Adinazolam can be decreased when it is combined with Etravirine.Approved
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Etravirine.Approved
AlbendazoleThe serum concentration of Albendazole can be decreased when it is combined with Etravirine.Approved, Vet Approved
AlclometasoneThe serum concentration of Alclometasone can be decreased when it is combined with Etravirine.Approved
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Etravirine.Experimental
AlfentanilThe serum concentration of Alfentanil can be decreased when it is combined with Etravirine.Approved, Illicit
AlfuzosinThe serum concentration of Alfuzosin can be decreased when it is combined with Etravirine.Approved, Investigational
AliskirenThe serum concentration of Aliskiren can be decreased when it is combined with Etravirine.Approved, Investigational
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Etravirine.Approved, Investigational
AllylestrenolThe serum concentration of Allylestrenol can be decreased when it is combined with Etravirine.Approved
AlmotriptanThe serum concentration of Almotriptan can be decreased when it is combined with Etravirine.Approved, Investigational
AlogliptinThe serum concentration of Etravirine can be decreased when it is combined with Alogliptin.Approved
AlosetronThe serum concentration of Alosetron can be decreased when it is combined with Etravirine.Approved, Withdrawn
Alpha-1-proteinase inhibitorThe serum concentration of Etravirine can be decreased when it is combined with Alpha-1-proteinase inhibitor.Approved
AlprazolamThe serum concentration of Alprazolam can be decreased when it is combined with Etravirine.Approved, Illicit, Investigational
AmbrisentanThe serum concentration of Ambrisentan can be decreased when it is combined with Etravirine.Approved, Investigational
AmbroxolThe serum concentration of Ambroxol can be decreased when it is combined with Etravirine.Approved
AminophenazoneThe serum concentration of Aminophenazone can be decreased when it is combined with Etravirine.Approved, Withdrawn
AminophyllineThe serum concentration of Aminophylline can be decreased when it is combined with Etravirine.Approved
AmiodaroneThe serum concentration of Amiodarone can be decreased when it is combined with Etravirine.Approved, Investigational
AmitriptylineThe serum concentration of Amitriptyline can be decreased when it is combined with Etravirine.Approved
AmlodipineThe serum concentration of Amlodipine can be decreased when it is combined with Etravirine.Approved
AmorolfineThe serum concentration of Etravirine can be increased when it is combined with Amorolfine.Approved
AmoxicillinThe metabolism of Amoxicillin can be decreased when combined with Etravirine.Approved, Vet Approved
Amphotericin BThe serum concentration of Etravirine can be increased when it is combined with Amphotericin B.Approved, Investigational
AmprenavirThe serum concentration of Etravirine can be decreased when it is combined with Amprenavir.Approved
AN2690The serum concentration of Etravirine can be increased when it is combined with AN2690.Investigational
AnidulafunginThe serum concentration of Etravirine can be increased when it is combined with Anidulafungin.Approved, Investigational
AntipyrineThe serum concentration of Antipyrine can be decreased when it is combined with Etravirine.Approved
Antithrombin III humanThe serum concentration of Etravirine can be decreased when it is combined with Antithrombin III human.Approved
ApixabanThe serum concentration of Etravirine can be decreased when it is combined with Apixaban.Approved
ApremilastThe serum concentration of Apremilast can be decreased when it is combined with Etravirine.Approved, Investigational
AprepitantThe serum concentration of Etravirine can be increased when it is combined with Aprepitant.Approved, Investigational
AprotininThe serum concentration of Etravirine can be decreased when it is combined with Aprotinin.Approved, Withdrawn
Arachidonic AcidThe metabolism of Arachidonic Acid can be decreased when combined with Etravirine.Experimental
ArformoterolThe metabolism of Arformoterol can be decreased when combined with Etravirine.Approved, Investigational
ArgatrobanThe serum concentration of Etravirine can be decreased when it is combined with Argatroban.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be decreased when it is combined with Etravirine.Approved, Investigational
ArmodafinilThe metabolism of Etravirine can be decreased when combined with Armodafinil.Approved, Investigational
Arsenic trioxideThe serum concentration of Arsenic trioxide can be increased when it is combined with Etravirine.Approved, Investigational
ArtemetherThe serum concentration of the active metabolites of Artemether can be reduced when Artemether is used in combination with Etravirine resulting in a loss in efficacy.Approved
AsenapineThe serum concentration of Asenapine can be decreased when it is combined with Etravirine.Approved
AstemizoleThe serum concentration of Astemizole can be decreased when it is combined with Etravirine.Approved, Withdrawn
AsunaprevirThe serum concentration of Etravirine can be decreased when it is combined with Asunaprevir.Approved, Investigational
AtazanavirThe serum concentration of Etravirine can be increased when it is combined with Atazanavir.Approved, Investigational
AtenololThe serum concentration of Atenolol can be increased when it is combined with Etravirine.Approved
AtomoxetineThe metabolism of Etravirine can be decreased when combined with Atomoxetine.Approved
AtorvastatinThe serum concentration of Atorvastatin can be decreased when it is combined with Etravirine.Approved
AvanafilThe serum concentration of Avanafil can be decreased when it is combined with Etravirine.Approved
AxitinibThe serum concentration of Axitinib can be decreased when it is combined with Etravirine.Approved, Investigational
AzelastineThe serum concentration of Azelastine can be decreased when it is combined with Etravirine.Approved
AzithromycinThe serum concentration of Azithromycin can be decreased when it is combined with Etravirine.Approved
Bafilomycin A1The serum concentration of Etravirine can be increased when it is combined with Bafilomycin A1.Experimental
BanoxantroneThe serum concentration of Banoxantrone can be decreased when it is combined with Etravirine.Investigational
BatimastatThe serum concentration of Etravirine can be decreased when it is combined with Batimastat.Experimental
BedaquilineThe serum concentration of Bedaquiline can be decreased when it is combined with Etravirine.Approved
BenazeprilThe serum concentration of Etravirine can be decreased when it is combined with Benazepril.Approved, Investigational
BenzamidineThe serum concentration of Etravirine can be decreased when it is combined with Benzamidine.Experimental
BenzatropineThe metabolism of Benzatropine can be decreased when combined with Etravirine.Approved
Benzoic AcidThe serum concentration of Etravirine can be increased when it is combined with Benzoic Acid.Approved
BenzphetamineThe serum concentration of Benzphetamine can be decreased when it is combined with Etravirine.Approved, Illicit
Benzyl alcoholThe serum concentration of Benzyl alcohol can be decreased when it is combined with Etravirine.Approved
BepridilThe serum concentration of Bepridil can be decreased when it is combined with Etravirine.Approved, Withdrawn
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Etravirine.Approved, Vet Approved
BexaroteneThe serum concentration of Etravirine can be decreased when it is combined with Bexarotene.Approved, Investigational
BezafibrateThe serum concentration of Bezafibrate can be decreased when it is combined with Etravirine.Approved
Bi201335The serum concentration of Etravirine can be decreased when it is combined with Bi201335.Investigational
BicalutamideThe serum concentration of Bicalutamide can be decreased when it is combined with Etravirine.Approved
BifonazoleThe serum concentration of Etravirine can be increased when it is combined with Bifonazole.Approved
BisoprololThe serum concentration of Bisoprolol can be decreased when it is combined with Etravirine.Approved
BivalirudinThe serum concentration of Etravirine can be decreased when it is combined with Bivalirudin.Approved, Investigational
BoceprevirThe serum concentration of Etravirine can be decreased when it is combined with Boceprevir.Approved
BortezomibThe serum concentration of Bortezomib can be decreased when it is combined with Etravirine.Approved, Investigational
BosentanThe serum concentration of Bosentan can be increased when it is combined with Etravirine.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be decreased when it is combined with Etravirine.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Etravirine.Approved
BrexpiprazoleThe serum concentration of Brexpiprazole can be decreased when it is combined with Etravirine.Approved
BrinzolamideThe serum concentration of Brinzolamide can be decreased when it is combined with Etravirine.Approved
BromazepamThe serum concentration of Bromazepam can be decreased when it is combined with Etravirine.Approved, Illicit
BromocriptineThe serum concentration of Bromocriptine can be decreased when it is combined with Etravirine.Approved, Investigational
BrompheniramineThe serum concentration of Brompheniramine can be decreased when it is combined with Etravirine.Approved
BudesonideThe serum concentration of Budesonide can be decreased when it is combined with Etravirine.Approved
BupivacaineThe serum concentration of Bupivacaine can be decreased when it is combined with Etravirine.Approved, Investigational
BuprenorphineThe serum concentration of Buprenorphine can be decreased when it is combined with Etravirine.Approved, Illicit, Investigational, Vet Approved
BupropionThe serum concentration of Bupropion can be decreased when it is combined with Etravirine.Approved
BuspironeThe serum concentration of Buspirone can be decreased when it is combined with Etravirine.Approved, Investigational
BusulfanThe serum concentration of Busulfan can be decreased when it is combined with Etravirine.Approved, Investigational
ButenafineThe serum concentration of Etravirine can be increased when it is combined with Butenafine.Approved
ButoconazoleThe serum concentration of Etravirine can be increased when it is combined with Butoconazole.Approved
CabazitaxelThe serum concentration of Cabazitaxel can be decreased when it is combined with Etravirine.Approved
CabergolineThe serum concentration of Cabergoline can be decreased when it is combined with Etravirine.Approved
CabozantinibThe serum concentration of Cabozantinib can be decreased when it is combined with Etravirine.Approved
CaffeineThe serum concentration of Caffeine can be decreased when it is combined with Etravirine.Approved
CalcitriolThe serum concentration of Calcitriol can be decreased when it is combined with Etravirine.Approved, Nutraceutical
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Etravirine.Experimental
CanagliflozinThe serum concentration of Canagliflozin can be decreased when it is combined with Etravirine.Approved
CandesartanThe metabolism of Candesartan can be decreased when combined with Etravirine.Approved
CandicidinThe serum concentration of Etravirine can be increased when it is combined with Candicidin.Withdrawn
CandoxatrilThe serum concentration of Etravirine can be decreased when it is combined with Candoxatril.Experimental
CandoxatrilatThe serum concentration of Etravirine can be decreased when it is combined with Candoxatrilat.Experimental
CapecitabineThe metabolism of Etravirine can be decreased when combined with Capecitabine.Approved, Investigational
CaptoprilThe serum concentration of Etravirine can be decreased when it is combined with Captopril.Approved
CarbamazepineThe serum concentration of Etravirine can be decreased when it is combined with Carbamazepine.Approved, Investigational
CarbinoxamineThe serum concentration of Carbinoxamine can be decreased when it is combined with Etravirine.Approved
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Etravirine.Approved
CariprazineThe serum concentration of Cariprazine can be decreased when it is combined with Etravirine.Approved
CarisoprodolThe metabolism of Carisoprodol can be decreased when combined with Etravirine.Approved
CarvedilolThe serum concentration of Carvedilol can be increased when it is combined with Etravirine.Approved, Investigational
CaspofunginThe serum concentration of Etravirine can be increased when it is combined with Caspofungin.Approved
CelecoxibThe serum concentration of Celecoxib can be decreased when it is combined with Etravirine.Approved, Investigational
CeliprololThe serum concentration of Celiprolol can be decreased when it is combined with Etravirine.Approved, Investigational
CephalexinThe serum concentration of Cephalexin can be decreased when it is combined with Etravirine.Approved, Vet Approved
CeritinibThe serum concentration of Etravirine can be increased when it is combined with Ceritinib.Approved
CerivastatinThe serum concentration of Cerivastatin can be decreased when it is combined with Etravirine.Withdrawn
CeruleninThe serum concentration of Etravirine can be increased when it is combined with Cerulenin.Approved
CevimelineThe serum concentration of Cevimeline can be decreased when it is combined with Etravirine.Approved
Chenodeoxycholic acidThe serum concentration of Chenodeoxycholic acid can be decreased when it is combined with Etravirine.Approved
ChloramphenicolThe metabolism of Etravirine can be decreased when combined with Chloramphenicol.Approved, Vet Approved
ChlordiazepoxideThe serum concentration of Chlordiazepoxide can be decreased when it is combined with Etravirine.Approved, Illicit
ChloroquineThe serum concentration of Chloroquine can be decreased when it is combined with Etravirine.Approved, Vet Approved
ChloroxineThe serum concentration of Etravirine can be increased when it is combined with Chloroxine.Approved
ChlorphenamineThe serum concentration of Chlorphenamine can be decreased when it is combined with Etravirine.Approved
ChlorpromazineThe serum concentration of Chlorpromazine can be decreased when it is combined with Etravirine.Approved, Vet Approved
ChlorpropamideThe metabolism of Chlorpropamide can be decreased when combined with Etravirine.Approved
ChlorzoxazoneThe serum concentration of Chlorzoxazone can be decreased when it is combined with Etravirine.Approved
CholecalciferolThe serum concentration of Cholecalciferol can be decreased when it is combined with Etravirine.Approved, Nutraceutical
ChymostatinThe serum concentration of Etravirine can be decreased when it is combined with Chymostatin.Experimental
CiclesonideThe serum concentration of Ciclesonide can be decreased when it is combined with Etravirine.Approved, Investigational
CiclopiroxThe serum concentration of Etravirine can be increased when it is combined with Ciclopirox.Approved, Investigational
CilastatinThe serum concentration of Etravirine can be decreased when it is combined with Cilastatin.Approved
CilazaprilThe serum concentration of Etravirine can be decreased when it is combined with Cilazapril.Approved
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Etravirine.Approved
CimetidineThe serum concentration of Cimetidine can be increased when it is combined with Etravirine.Approved
CinacalcetThe serum concentration of Cinacalcet can be decreased when it is combined with Etravirine.Approved
CinnarizineThe metabolism of Cinnarizine can be decreased when combined with Etravirine.Approved
CiprofloxacinThe serum concentration of Ciprofloxacin can be increased when it is combined with Etravirine.Approved, Investigational
CisaprideThe serum concentration of Cisapride can be decreased when it is combined with Etravirine.Approved, Investigational, Withdrawn
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Etravirine.Approved
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Etravirine.Approved
ClarithromycinThe serum concentration of the active metabolites of Clarithromycin can be increased when Clarithromycin is used in combination with Etravirine.Approved
ClemastineThe metabolism of Etravirine can be decreased when combined with Clemastine.Approved
ClindamycinThe serum concentration of Clindamycin can be decreased when it is combined with Etravirine.Approved, Vet Approved
ClobazamThe serum concentration of Clobazam can be decreased when it is combined with Etravirine.Approved, Illicit
ClofazimineThe serum concentration of Clofazimine can be decreased when it is combined with Etravirine.Approved, Investigational
ClofibrateThe serum concentration of Clofibrate can be decreased when it is combined with Etravirine.Approved
clomethiazoleThe serum concentration of clomethiazole can be decreased when it is combined with Etravirine.Investigational
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Etravirine.Approved, Investigational
ClomipramineThe serum concentration of Clomipramine can be decreased when it is combined with Etravirine.Approved, Vet Approved
ClonazepamThe serum concentration of Clonazepam can be decreased when it is combined with Etravirine.Approved, Illicit
ClonidineThe serum concentration of Clonidine can be decreased when it is combined with Etravirine.Approved
ClopidogrelThe serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Etravirine resulting in a loss in efficacy.Approved, Nutraceutical
ClorazepateThe serum concentration of Clorazepate can be decreased when it is combined with Etravirine.Approved, Illicit
ClotiazepamThe serum concentration of Clotiazepam can be decreased when it is combined with Etravirine.Approved, Illicit
ClotrimazoleThe serum concentration of Etravirine can be increased when it is combined with Clotrimazole.Approved, Vet Approved
ClozapineThe serum concentration of Clozapine can be decreased when it is combined with Etravirine.Approved
CobicistatThe metabolism of Etravirine can be decreased when combined with Cobicistat.Approved
CobimetinibThe serum concentration of Cobimetinib can be decreased when it is combined with Etravirine.Approved
CocaineThe serum concentration of Cocaine can be decreased when it is combined with Etravirine.Approved, Illicit
CodeineThe serum concentration of Codeine can be decreased when it is combined with Etravirine.Approved, Illicit
Coenzyme Q10The serum concentration of Coenzyme Q10 can be decreased when it is combined with Etravirine.Experimental
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Etravirine.Approved
ConivaptanThe serum concentration of Etravirine can be increased when it is combined with Conivaptan.Approved, Investigational
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be decreased when it is combined with Etravirine.Approved
CordycepinThe serum concentration of Etravirine can be increased when it is combined with Cordycepin.Investigational
Cortisone acetateThe serum concentration of Cortisone acetate can be decreased when it is combined with Etravirine.Approved
CrizotinibThe serum concentration of Crizotinib can be decreased when it is combined with Etravirine.Approved
CyclobenzaprineThe serum concentration of Cyclobenzaprine can be decreased when it is combined with Etravirine.Approved
CyclophosphamideThe serum concentration of Cyclophosphamide can be decreased when it is combined with Etravirine.Approved, Investigational
CyclosporineThe serum concentration of Etravirine can be increased when it is combined with Cyclosporine.Approved, Investigational, Vet Approved
CytarabineThe serum concentration of Cytarabine can be decreased when it is combined with Etravirine.Approved, Investigational
Dabigatran etexilateThe serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Etravirine.Approved
DabrafenibThe serum concentration of Etravirine can be decreased when it is combined with Dabrafenib.Approved
DaclatasvirThe serum concentration of Daclatasvir can be decreased when it is combined with Etravirine.Approved
DactinomycinThe serum concentration of Dactinomycin can be increased when it is combined with Etravirine.Approved
DantroleneThe serum concentration of Dantrolene can be decreased when it is combined with Etravirine.Approved
DapagliflozinThe serum concentration of Dapagliflozin can be decreased when it is combined with Etravirine.Approved
DapsoneThe serum concentration of Dapsone can be decreased when it is combined with Etravirine.Approved, Investigational
DarifenacinThe serum concentration of Darifenacin can be decreased when it is combined with Etravirine.Approved, Investigational
DarunavirThe serum concentration of Etravirine can be decreased when it is combined with Darunavir.Approved
DasabuvirThe serum concentration of Dasabuvir can be decreased when it is combined with Etravirine.Approved
DasatinibThe serum concentration of Etravirine can be increased when it is combined with Dasatinib.Approved, Investigational
DaunorubicinThe serum concentration of Daunorubicin can be decreased when it is combined with Etravirine.Approved
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Etravirine.Approved
Decanoic AcidThe serum concentration of Etravirine can be increased when it is combined with Decanoic Acid.Experimental
DeferasiroxThe serum concentration of Etravirine can be decreased when it is combined with Deferasirox.Approved, Investigational
DelavirdineThe serum concentration of Etravirine can be decreased when it is combined with Delavirdine.Approved
DesipramineThe metabolism of Desipramine can be decreased when combined with Etravirine.Approved
DesvenlafaxineThe serum concentration of Desvenlafaxine can be decreased when it is combined with Etravirine.Approved
DexamethasoneThe serum concentration of Etravirine can be decreased when it is combined with Dexamethasone.Approved, Investigational, Vet Approved
DextromethorphanThe serum concentration of Dextromethorphan can be decreased when it is combined with Etravirine.Approved
DextropropoxypheneThe serum concentration of Dextropropoxyphene can be decreased when it is combined with Etravirine.Approved, Illicit, Withdrawn
DiazepamThe serum concentration of Diazepam can be decreased when it is combined with Etravirine.Approved, Illicit, Vet Approved
DiclofenacThe serum concentration of Diclofenac can be decreased when it is combined with Etravirine.Approved, Vet Approved
DicoumarolThe metabolism of Dicoumarol can be decreased when combined with Etravirine.Approved
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Etravirine.Approved
DigitoxinThe serum concentration of Digitoxin can be decreased when it is combined with Etravirine.Approved
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Etravirine.Approved
DihydrocodeineThe serum concentration of Dihydrocodeine can be decreased when it is combined with Etravirine.Approved, Illicit
DihydroergotamineThe serum concentration of Dihydroergotamine can be decreased when it is combined with Etravirine.Approved
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Etravirine.Illicit
DiltiazemThe serum concentration of Diltiazem can be decreased when it is combined with Etravirine.Approved
DiphenhydramineThe metabolism of Diphenhydramine can be decreased when combined with Etravirine.Approved
DipyridamoleThe serum concentration of Dipyridamole can be increased when it is combined with Etravirine.Approved
DisopyramideThe serum concentration of Disopyramide can be decreased when it is combined with Etravirine.Approved
DisulfiramThe serum concentration of Disulfiram can be decreased when it is combined with Etravirine.Approved
DocetaxelThe serum concentration of Docetaxel can be decreased when it is combined with Etravirine.Approved, Investigational
DofetilideThe serum concentration of Dofetilide can be decreased when it is combined with Etravirine.Approved
DolasetronThe serum concentration of Dolasetron can be decreased when it is combined with Etravirine.Approved
DolutegravirThe serum concentration of Dolutegravir can be decreased when it is combined with Etravirine.Approved
DomperidoneThe serum concentration of Domperidone can be decreased when it is combined with Etravirine.Approved, Investigational, Vet Approved
DonepezilThe serum concentration of Donepezil can be decreased when it is combined with Etravirine.Approved
DopamineThe metabolism of Dopamine can be decreased when combined with Etravirine.Approved
DorzolamideThe serum concentration of Dorzolamide can be decreased when it is combined with Etravirine.Approved
DoxazosinThe metabolism of Doxazosin can be decreased when combined with Etravirine.Approved
DoxepinThe serum concentration of Doxepin can be decreased when it is combined with Etravirine.Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Etravirine.Approved, Investigational
DoxorubicinThe serum concentration of Doxorubicin can be decreased when it is combined with Etravirine.Approved, Investigational
DoxycyclineThe metabolism of Etravirine can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Etravirine.Approved, Illicit
DronedaroneThe serum concentration of Dronedarone can be decreased when it is combined with Etravirine.Approved
DutasterideThe serum concentration of Dutasteride can be decreased when it is combined with Etravirine.Approved, Investigational
EcabetThe serum concentration of Etravirine can be decreased when it is combined with Ecabet.Approved, Investigational
EconazoleThe serum concentration of Etravirine can be increased when it is combined with Econazole.Approved
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Etravirine.Approved
EfavirenzThe serum concentration of Etravirine can be decreased when it is combined with Efavirenz.Approved, Investigational
EfinaconazoleThe serum concentration of Etravirine can be increased when it is combined with Efinaconazole.Approved
ElafinThe serum concentration of Etravirine can be decreased when it is combined with Elafin.Investigational
EletriptanThe serum concentration of Eletriptan can be decreased when it is combined with Etravirine.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be decreased when it is combined with Etravirine.Approved
ElvitegravirThe serum concentration of Elvitegravir can be decreased when it is combined with Etravirine.Approved
EnalaprilThe serum concentration of Etravirine can be decreased when it is combined with Enalapril.Approved, Vet Approved
EnalaprilatThe serum concentration of Etravirine can be decreased when it is combined with Enalaprilat.Approved
EnalkirenThe serum concentration of Etravirine can be decreased when it is combined with Enalkiren.Experimental
EnfuvirtideThe metabolism of Enfuvirtide can be decreased when combined with Etravirine.Approved, Investigational
EnzalutamideThe serum concentration of Enzalutamide can be decreased when it is combined with Etravirine.Approved
EpinastineThe serum concentration of Epinastine can be decreased when it is combined with Etravirine.Approved, Investigational
EplerenoneThe serum concentration of Eplerenone can be decreased when it is combined with Etravirine.Approved
EpoprostenolThe metabolism of Epoprostenol can be decreased when combined with Etravirine.Approved
ErgocalciferolThe serum concentration of Ergocalciferol can be decreased when it is combined with Etravirine.Approved, Nutraceutical
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be decreased when it is combined with Etravirine.Approved
ErgonovineThe serum concentration of Ergonovine can be decreased when it is combined with Etravirine.Approved
ErgotamineThe serum concentration of Ergotamine can be decreased when it is combined with Etravirine.Approved
ErlotinibThe serum concentration of Erlotinib can be decreased when it is combined with Etravirine.Approved, Investigational
ErythromycinThe serum concentration of Erythromycin can be decreased when it is combined with Etravirine.Approved, Vet Approved
EscitalopramThe serum concentration of Escitalopram can be decreased when it is combined with Etravirine.Approved, Investigational
Eslicarbazepine acetateThe serum concentration of Etravirine can be decreased when it is combined with Eslicarbazepine acetate.Approved
EsomeprazoleThe serum concentration of Esomeprazole can be decreased when it is combined with Etravirine.Approved, Investigational
EstazolamThe serum concentration of Estazolam can be decreased when it is combined with Etravirine.Approved, Illicit
EstradiolThe serum concentration of Estradiol can be decreased when it is combined with Etravirine.Approved, Investigational, Vet Approved
Estradiol valerate/DienogestThe serum concentration of Estradiol valerate/Dienogest can be decreased when it is combined with Etravirine.Approved
EstramustineThe serum concentration of Estramustine can be decreased when it is combined with Etravirine.Approved
EstriolThe serum concentration of Estriol can be increased when it is combined with Etravirine.Approved, Vet Approved
EstroneThe serum concentration of Estrone can be decreased when it is combined with Etravirine.Approved
Estrone sulfateThe serum concentration of Estrone sulfate can be decreased when it is combined with Etravirine.Approved
EszopicloneThe serum concentration of Eszopiclone can be decreased when it is combined with Etravirine.Approved
EthanolThe serum concentration of Ethanol can be decreased when it is combined with Etravirine.Approved
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Etravirine.Approved
EthosuximideThe serum concentration of Ethosuximide can be decreased when it is combined with Etravirine.Approved
EthylmorphineThe serum concentration of Ethylmorphine can be decreased when it is combined with Etravirine.Approved, Illicit
EtodolacThe metabolism of Etodolac can be decreased when combined with Etravirine.Approved, Investigational, Vet Approved
EtonogestrelThe serum concentration of Etonogestrel can be decreased when it is combined with Etravirine.Approved, Investigational
EtoposideThe serum concentration of Etoposide can be decreased when it is combined with Etravirine.Approved
EtoricoxibThe serum concentration of Etoricoxib can be decreased when it is combined with Etravirine.Approved, Investigational
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Etravirine.Approved
ExemestaneThe serum concentration of Exemestane can be decreased when it is combined with Etravirine.Approved, Investigational
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Etravirine.Approved
FamciclovirThe serum concentration of Famciclovir can be decreased when it is combined with Etravirine.Approved
FamotidineThe metabolism of Famotidine can be decreased when combined with Etravirine.Approved
FelbamateThe serum concentration of Felbamate can be decreased when it is combined with Etravirine.Approved
FelodipineThe serum concentration of Felodipine can be decreased when it is combined with Etravirine.Approved, Investigational
FenofibrateThe serum concentration of Fenofibrate can be decreased when it is combined with Etravirine.Approved
FentanylThe serum concentration of Fentanyl can be decreased when it is combined with Etravirine.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe serum concentration of Fesoterodine can be decreased when it is combined with Etravirine.Approved
FexofenadineThe serum concentration of Fexofenadine can be increased when it is combined with Etravirine.Approved
FidaxomicinThe serum concentration of Fidaxomicin can be increased when it is combined with Etravirine.Approved
FinasterideThe serum concentration of Finasteride can be decreased when it is combined with Etravirine.Approved
FingolimodThe serum concentration of Fingolimod can be decreased when it is combined with Etravirine.Approved, Investigational
FlecainideThe serum concentration of Flecainide can be decreased when it is combined with Etravirine.Approved, Withdrawn
FlibanserinThe serum concentration of Flibanserin can be decreased when it is combined with Etravirine.Approved
FloxuridineThe metabolism of Etravirine can be decreased when combined with Floxuridine.Approved
FluconazoleThe serum concentration of Etravirine can be increased when it is combined with Fluconazole.Approved
FlucytosineThe serum concentration of Etravirine can be increased when it is combined with Flucytosine.Approved
FlunarizineThe metabolism of Flunarizine can be decreased when combined with Etravirine.Approved
FlunisolideThe serum concentration of Flunisolide can be decreased when it is combined with Etravirine.Approved, Investigational
FlunitrazepamThe serum concentration of Flunitrazepam can be decreased when it is combined with Etravirine.Approved, Illicit
FluorometholoneThe serum concentration of Fluorometholone can be decreased when it is combined with Etravirine.Approved
FluorouracilThe metabolism of Etravirine can be decreased when combined with Fluorouracil.Approved
FluoxetineThe serum concentration of Fluoxetine can be decreased when it is combined with Etravirine.Approved, Vet Approved
FlurazepamThe serum concentration of Flurazepam can be decreased when it is combined with Etravirine.Approved, Illicit
FlurbiprofenThe metabolism of Flurbiprofen can be decreased when combined with Etravirine.Approved, Investigational
FlutamideThe serum concentration of Flutamide can be decreased when it is combined with Etravirine.Approved
Fluticasone furoateThe serum concentration of Fluticasone furoate can be decreased when it is combined with Etravirine.Approved
Fluticasone PropionateThe serum concentration of Fluticasone Propionate can be decreased when it is combined with Etravirine.Approved
FluvastatinThe serum concentration of Fluvastatin can be decreased when it is combined with Etravirine.Approved
FluvoxamineThe metabolism of Etravirine can be decreased when combined with Fluvoxamine.Approved, Investigational
FormoterolThe metabolism of Formoterol can be decreased when combined with Etravirine.Approved, Investigational
FosamprenavirThe serum concentration of the active metabolites of Fosamprenavir can be increased when Fosamprenavir is used in combination with Etravirine.Approved
FosaprepitantThe serum concentration of Etravirine can be increased when it is combined with Fosaprepitant.Approved
FosinoprilThe serum concentration of Etravirine can be decreased when it is combined with Fosinopril.Approved
FosphenytoinThe serum concentration of Etravirine can be decreased when it is combined with Fosphenytoin.Approved
FulvestrantThe serum concentration of Fulvestrant can be decreased when it is combined with Etravirine.Approved, Investigational
Fusidic AcidThe serum concentration of Etravirine can be increased when it is combined with Fusidic Acid.Approved
GabexateThe serum concentration of Etravirine can be decreased when it is combined with Gabexate.Investigational
GalantamineThe serum concentration of Galantamine can be decreased when it is combined with Etravirine.Approved
GavestinelThe metabolism of Gavestinel can be decreased when combined with Etravirine.Investigational
GefitinibThe serum concentration of Gefitinib can be decreased when it is combined with Etravirine.Approved, Investigational
GeldanamycinThe serum concentration of Etravirine can be decreased when it is combined with Geldanamycin.Experimental
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Etravirine.Approved
GemfibrozilThe metabolism of Etravirine can be decreased when combined with Gemfibrozil.Approved
GliclazideThe metabolism of Gliclazide can be decreased when combined with Etravirine.Approved
GlimepirideThe metabolism of Glimepiride can be decreased when combined with Etravirine.Approved
GlipizideThe serum concentration of Glipizide can be decreased when it is combined with Etravirine.Approved
GlucosamineThe metabolism of Glucosamine can be decreased when combined with Etravirine.Approved
GlyburideThe serum concentration of Glyburide can be decreased when it is combined with Etravirine.Approved
GlyphosateThe serum concentration of Etravirine can be increased when it is combined with Glyphosate.Experimental
GM6001The serum concentration of Etravirine can be decreased when it is combined with GM6001.Experimental
GranisetronThe serum concentration of Granisetron can be decreased when it is combined with Etravirine.Approved, Investigational
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Etravirine.Approved
GrepafloxacinThe serum concentration of Grepafloxacin can be decreased when it is combined with Etravirine.Withdrawn
GriseofulvinThe serum concentration of Etravirine can be increased when it is combined with Griseofulvin.Approved, Vet Approved
GuanfacineThe serum concentration of Guanfacine can be decreased when it is combined with Etravirine.Approved, Investigational
HalofantrineThe serum concentration of Halofantrine can be decreased when it is combined with Etravirine.Approved
HaloperidolThe serum concentration of Haloperidol can be decreased when it is combined with Etravirine.Approved
HaloproginThe serum concentration of Etravirine can be increased when it is combined with Haloprogin.Approved, Withdrawn
HalothaneThe serum concentration of Halothane can be decreased when it is combined with Etravirine.Approved, Vet Approved
HexetidineThe serum concentration of Etravirine can be increased when it is combined with Hexetidine.Approved
HexobarbitalThe serum concentration of Hexobarbital can be decreased when it is combined with Etravirine.Approved
HirulogThe serum concentration of Etravirine can be decreased when it is combined with Hirulog.Experimental
Histamine PhosphateThe serum concentration of Histamine Phosphate can be decreased when it is combined with Etravirine.Approved
HydrocodoneThe serum concentration of Hydrocodone can be decreased when it is combined with Etravirine.Approved, Illicit
HydrocortisoneThe serum concentration of Hydrocortisone can be decreased when it is combined with Etravirine.Approved, Vet Approved
HydromorphoneThe serum concentration of Hydromorphone can be decreased when it is combined with Etravirine.Approved, Illicit
Hydroxyprogesterone caproateThe serum concentration of Hydroxyprogesterone caproate can be decreased when it is combined with Etravirine.Approved
IbrutinibThe serum concentration of Ibrutinib can be decreased when it is combined with Etravirine.Approved
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Etravirine.Approved
IdarubicinThe metabolism of Idarubicin can be decreased when combined with Etravirine.Approved
IdelalisibThe serum concentration of Etravirine can be increased when it is combined with Idelalisib.Approved
idraparinuxThe serum concentration of Etravirine can be decreased when it is combined with idraparinux.Investigational
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Etravirine resulting in a loss in efficacy.Approved
IloperidoneThe serum concentration of Iloperidone can be decreased when it is combined with Etravirine.Approved
ImatinibThe serum concentration of Imatinib can be decreased when it is combined with Etravirine.Approved
ImidaprilThe serum concentration of Etravirine can be decreased when it is combined with Imidapril.Investigational
ImipramineThe serum concentration of Imipramine can be decreased when it is combined with Etravirine.Approved
ImiquimodThe serum concentration of Imiquimod can be decreased when it is combined with Etravirine.Approved, Investigational
IndacaterolThe serum concentration of Indacaterol can be decreased when it is combined with Etravirine.Approved
IndapamideThe serum concentration of Indapamide can be decreased when it is combined with Etravirine.Approved
IndinavirThe serum concentration of Etravirine can be decreased when it is combined with Indinavir.Approved
indisulamThe metabolism of indisulam can be decreased when combined with Etravirine.Investigational
IndomethacinThe serum concentration of Indomethacin can be increased when it is combined with Etravirine.Approved, Investigational
Ipratropium bromideThe serum concentration of Ipratropium bromide can be decreased when it is combined with Etravirine.Approved
IrbesartanThe metabolism of Etravirine can be decreased when combined with Irbesartan.Approved, Investigational
IrinotecanThe serum concentration of Irinotecan can be decreased when it is combined with Etravirine.Approved, Investigational
IsavuconazoniumThe serum concentration of Isavuconazonium can be decreased when it is combined with Etravirine.Approved, Investigational
IsoconazoleThe serum concentration of Etravirine can be increased when it is combined with Isoconazole.Approved
IsoflurophateThe serum concentration of Etravirine can be decreased when it is combined with Isoflurophate.Approved, Withdrawn
IsoniazidThe metabolism of Etravirine can be decreased when combined with Isoniazid.Approved
Isosorbide DinitrateThe serum concentration of Isosorbide Dinitrate can be decreased when it is combined with Etravirine.Approved
Isosorbide MononitrateThe serum concentration of Isosorbide Mononitrate can be decreased when it is combined with Etravirine.Approved
IsradipineThe serum concentration of Isradipine can be decreased when it is combined with Etravirine.Approved
ItraconazoleThe serum concentration of Etravirine can be increased when it is combined with Itraconazole.Approved, Investigational
IvabradineThe serum concentration of Ivabradine can be decreased when it is combined with Etravirine.Approved
IvacaftorThe serum concentration of Etravirine can be increased when it is combined with Ivacaftor.Approved
IvermectinThe serum concentration of Ivermectin can be decreased when it is combined with Etravirine.Approved, Vet Approved
IxabepiloneThe serum concentration of Ixabepilone can be decreased when it is combined with Etravirine.Approved, Investigational
IxazomibThe serum concentration of Etravirine can be decreased when it is combined with Ixazomib.Approved
KetamineThe serum concentration of Ketamine can be decreased when it is combined with Etravirine.Approved, Vet Approved
KetazolamThe serum concentration of Ketazolam can be decreased when it is combined with Etravirine.Approved
KetobemidoneThe serum concentration of Ketobemidone can be decreased when it is combined with Etravirine.Approved
KetoconazoleThe serum concentration of Etravirine can be increased when it is combined with Ketoconazole.Approved, Investigational
KetoprofenThe metabolism of Ketoprofen can be decreased when combined with Etravirine.Approved, Vet Approved
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Etravirine.Approved, Investigational
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Etravirine.Approved, Investigational
LansoprazoleThe serum concentration of Lansoprazole can be decreased when it is combined with Etravirine.Approved, Investigational
LapatinibThe serum concentration of Lapatinib can be decreased when it is combined with Etravirine.Approved, Investigational
LaquinimodThe serum concentration of Laquinimod can be decreased when it is combined with Etravirine.Investigational
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Etravirine.Approved
LeflunomideThe metabolism of Etravirine can be decreased when combined with Leflunomide.Approved, Investigational
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Etravirine.Approved
LenvatinibThe serum concentration of Lenvatinib can be decreased when it is combined with Etravirine.Approved
LepirudinThe serum concentration of Etravirine can be decreased when it is combined with Lepirudin.Approved
LercanidipineThe serum concentration of Lercanidipine can be decreased when it is combined with Etravirine.Approved, Investigational
LesinuradThe metabolism of Lesinurad can be decreased when combined with Etravirine.Approved
LetrozoleThe serum concentration of Letrozole can be decreased when it is combined with Etravirine.Approved, Investigational
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Etravirine.Approved, Investigational
LevobupivacaineThe serum concentration of Levobupivacaine can be decreased when it is combined with Etravirine.Approved
LevocetirizineThe serum concentration of Levocetirizine can be decreased when it is combined with Etravirine.Approved
LevofloxacinThe serum concentration of Levofloxacin can be increased when it is combined with Etravirine.Approved, Investigational
Levomethadyl AcetateThe serum concentration of Levomethadyl Acetate can be decreased when it is combined with Etravirine.Approved
LevomilnacipranThe serum concentration of Levomilnacipran can be decreased when it is combined with Etravirine.Approved
LevonorgestrelThe serum concentration of Levonorgestrel can be decreased when it is combined with Etravirine.Approved, Investigational
LevothyroxineThe serum concentration of Levothyroxine can be decreased when it is combined with Etravirine.Approved
LicofeloneThe metabolism of Licofelone can be decreased when combined with Etravirine.Investigational
LidocaineThe serum concentration of Lidocaine can be decreased when it is combined with Etravirine.Approved, Vet Approved
LinagliptinThe serum concentration of Etravirine can be decreased when it is combined with Linagliptin.Approved
LisinoprilThe serum concentration of Etravirine can be decreased when it is combined with Lisinopril.Approved, Investigational
LisurideThe serum concentration of Lisuride can be decreased when it is combined with Etravirine.Approved
LomitapideThe serum concentration of Lomitapide can be decreased when it is combined with Etravirine.Approved
LoperamideThe serum concentration of Loperamide can be decreased when it is combined with Etravirine.Approved
LopinavirThe serum concentration of Etravirine can be decreased when it is combined with Lopinavir.Approved
LoratadineThe serum concentration of Loratadine can be decreased when it is combined with Etravirine.Approved
LorcaserinThe serum concentration of Lorcaserin can be decreased when it is combined with Etravirine.Approved
LornoxicamThe metabolism of Lornoxicam can be decreased when combined with Etravirine.Approved
LosartanThe serum concentration of Losartan can be decreased when it is combined with Etravirine.Approved
LovastatinThe serum concentration of Lovastatin can be decreased when it is combined with Etravirine.Approved, Investigational
LuliconazoleThe serum concentration of Etravirine can be increased when it is combined with Luliconazole.Approved
LumacaftorThe serum concentration of Etravirine can be decreased when it is combined with Lumacaftor.Approved
LumefantrineThe serum concentration of Lumefantrine can be decreased when it is combined with Etravirine.Approved
LumiracoxibThe metabolism of Lumiracoxib can be decreased when combined with Etravirine.Approved, Investigational
LurasidoneThe serum concentration of Lurasidone can be decreased when it is combined with Etravirine.Approved
MacitentanThe serum concentration of Macitentan can be decreased when it is combined with Etravirine.Approved
MannitolThe serum concentration of Mannitol can be increased when it is combined with Etravirine.Approved, Investigational
MaravirocThe serum concentration of Maraviroc can be decreased when it is combined with Etravirine.Approved, Investigational
MebendazoleThe serum concentration of Mebendazole can be decreased when it is combined with Etravirine.Approved, Vet Approved
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with Etravirine.Approved, Investigational
Mefenamic acidThe metabolism of Mefenamic acid can be decreased when combined with Etravirine.Approved
MefloquineThe serum concentration of Mefloquine can be decreased when it is combined with Etravirine.Approved
MelatoninThe metabolism of Melatonin can be decreased when combined with Etravirine.Approved, Nutraceutical, Vet Approved
MeloxicamThe serum concentration of Meloxicam can be decreased when it is combined with Etravirine.Approved, Vet Approved
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Etravirine.Investigational, Withdrawn
MeprobamateThe metabolism of Meprobamate can be decreased when combined with Etravirine.Approved, Illicit
MestranolThe metabolism of Mestranol can be decreased when combined with Etravirine.Approved
MethadoneThe serum concentration of Methadone can be decreased when it is combined with Etravirine.Approved
MethaqualoneThe serum concentration of Methaqualone can be decreased when it is combined with Etravirine.Illicit, Withdrawn
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Etravirine.Approved
MethoxsalenThe serum concentration of Methoxsalen can be decreased when it is combined with Etravirine.Approved
MethoxyfluraneThe serum concentration of Methoxyflurane can be decreased when it is combined with Etravirine.Approved, Vet Approved
MethsuximideThe metabolism of Methsuximide can be decreased when combined with Etravirine.Approved
MethylphenobarbitalThe metabolism of Methylphenobarbital can be decreased when combined with Etravirine.Approved
MethylprednisoloneThe serum concentration of Methylprednisolone can be decreased when it is combined with Etravirine.Approved, Vet Approved
MethyltestosteroneThe serum concentration of Methyltestosterone can be decreased when it is combined with Etravirine.Approved
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Etravirine.Approved, Investigational
MetronidazoleThe serum concentration of Metronidazole can be decreased when it is combined with Etravirine.Approved
MevastatinThe serum concentration of Etravirine can be increased when it is combined with Mevastatin.Experimental
MexiletineThe serum concentration of Mexiletine can be decreased when it is combined with Etravirine.Approved
MianserinThe serum concentration of Mianserin can be decreased when it is combined with Etravirine.Approved
MibefradilThe serum concentration of Mibefradil can be decreased when it is combined with Etravirine.Withdrawn
MicafunginThe serum concentration of Etravirine can be increased when it is combined with Micafungin.Approved, Investigational
MiconazoleThe serum concentration of Etravirine can be increased when it is combined with Miconazole.Approved, Investigational, Vet Approved
MidazolamThe serum concentration of Midazolam can be decreased when it is combined with Etravirine.Approved, Illicit
MifepristoneThe serum concentration of Etravirine can be increased when it is combined with Mifepristone.Approved, Investigational
MiltefosineThe serum concentration of Etravirine can be increased when it is combined with Miltefosine.Approved
MirabegronThe serum concentration of Mirabegron can be decreased when it is combined with Etravirine.Approved
MirtazapineThe serum concentration of Mirtazapine can be decreased when it is combined with Etravirine.Approved
MitotaneThe serum concentration of Etravirine can be decreased when it is combined with Mitotane.Approved
MitoxantroneThe serum concentration of Mitoxantrone can be increased when it is combined with Etravirine.Approved, Investigational
MoclobemideThe metabolism of Etravirine can be decreased when combined with Moclobemide.Approved
ModafinilThe serum concentration of Etravirine can be decreased when it is combined with Modafinil.Approved, Investigational
MoexiprilThe serum concentration of Etravirine can be decreased when it is combined with Moexipril.Approved
MonensinThe serum concentration of Etravirine can be increased when it is combined with Monensin.Vet Approved
MontelukastThe serum concentration of Montelukast can be decreased when it is combined with Etravirine.Approved
MorphineThe serum concentration of Morphine can be decreased when it is combined with Etravirine.Approved, Investigational
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be decreased when it is combined with Etravirine.Approved, Investigational
MyxothiazolThe serum concentration of Etravirine can be increased when it is combined with Myxothiazol.Experimental
N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-ProlineThe serum concentration of Etravirine can be decreased when it is combined with N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-Proline.Experimental
NadololThe serum concentration of Nadolol can be increased when it is combined with Etravirine.Approved
NafamostatThe serum concentration of Etravirine can be decreased when it is combined with Nafamostat.Investigational
NafcillinThe serum concentration of Etravirine can be decreased when it is combined with Nafcillin.Approved
NaftifineThe serum concentration of Etravirine can be increased when it is combined with Naftifine.Approved
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Etravirine.Approved
NaloxoneThe serum concentration of Naloxone can be decreased when it is combined with Etravirine.Approved, Vet Approved
NaproxenThe metabolism of Naproxen can be decreased when combined with Etravirine.Approved, Vet Approved
NatamycinThe serum concentration of Etravirine can be increased when it is combined with Natamycin.Approved
NateglinideThe serum concentration of Nateglinide can be decreased when it is combined with Etravirine.Approved, Investigational
NCX 4016The serum concentration of Etravirine can be decreased when it is combined with NCX 4016.Investigational
NefazodoneThe metabolism of Etravirine can be decreased when combined with Nefazodone.Approved, Withdrawn
NelfinavirThe serum concentration of Etravirine can be decreased when it is combined with Nelfinavir.Approved
NetupitantThe serum concentration of Etravirine can be increased when it is combined with Netupitant.Approved
NevirapineThe serum concentration of Etravirine can be decreased when it is combined with Nevirapine.Approved
NicardipineThe metabolism of Etravirine can be decreased when combined with Nicardipine.Approved
NiclosamideThe metabolism of Niclosamide can be decreased when combined with Etravirine.Approved, Vet Approved
NicotineThe serum concentration of Nicotine can be decreased when it is combined with Etravirine.Approved
NifedipineThe serum concentration of Nifedipine can be decreased when it is combined with Etravirine.Approved
NilotinibThe serum concentration of Nilotinib can be decreased when it is combined with Etravirine.Approved, Investigational
NilutamideThe metabolism of Nilutamide can be decreased when combined with Etravirine.Approved
NilvadipineThe serum concentration of Nilvadipine can be decreased when it is combined with Etravirine.Approved
NimodipineThe serum concentration of Nimodipine can be decreased when it is combined with Etravirine.Approved
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Etravirine.Approved
NisoldipineThe serum concentration of Nisoldipine can be decreased when it is combined with Etravirine.Approved
NitrazepamThe serum concentration of Nitrazepam can be decreased when it is combined with Etravirine.Approved
NitrendipineThe serum concentration of Nitrendipine can be decreased when it is combined with Etravirine.Approved
NitroaspirinThe serum concentration of Etravirine can be decreased when it is combined with Nitroaspirin.Investigational
NitroxolineThe serum concentration of Etravirine can be increased when it is combined with Nitroxoline.Approved
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Etravirine.Approved
NorethisteroneThe serum concentration of Norethisterone can be decreased when it is combined with Etravirine.Approved
NorgestrelThe serum concentration of Norgestrel can be decreased when it is combined with Etravirine.Approved
NortriptylineThe serum concentration of Nortriptyline can be decreased when it is combined with Etravirine.Approved
NystatinThe serum concentration of Etravirine can be increased when it is combined with Nystatin.Approved, Vet Approved
OlanzapineThe serum concentration of Olanzapine can be increased when it is combined with Etravirine.Approved, Investigational
OlaparibThe serum concentration of Olaparib can be decreased when it is combined with Etravirine.Approved
OlodaterolThe metabolism of Olodaterol can be decreased when combined with Etravirine.Approved
OlopatadineThe serum concentration of Olopatadine can be decreased when it is combined with Etravirine.Approved
OmapatrilatThe serum concentration of Etravirine can be decreased when it is combined with Omapatrilat.Investigational
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Etravirine.Approved
OmeprazoleThe serum concentration of Omeprazole can be decreased when it is combined with Etravirine.Approved, Investigational, Vet Approved
OndansetronThe serum concentration of Ondansetron can be decreased when it is combined with Etravirine.Approved
OrphenadrineThe serum concentration of Orphenadrine can be decreased when it is combined with Etravirine.Approved
OsimertinibThe serum concentration of Etravirine can be increased when it is combined with Osimertinib.Approved
OspemifeneThe serum concentration of Ospemifene can be decreased when it is combined with Etravirine.Approved
OtamixabanThe serum concentration of Etravirine can be decreased when it is combined with Otamixaban.Investigational
OxaprozinThe metabolism of Oxaprozin can be decreased when combined with Etravirine.Approved
OxazepamThe serum concentration of Oxazepam can be decreased when it is combined with Etravirine.Approved
OxiconazoleThe serum concentration of Etravirine can be increased when it is combined with Oxiconazole.Approved
OxybutyninThe serum concentration of Oxybutynin can be decreased when it is combined with Etravirine.Approved, Investigational
OxycodoneThe serum concentration of Oxycodone can be decreased when it is combined with Etravirine.Approved, Illicit, Investigational
OxymorphoneThe serum concentration of Oxymorphone can be decreased when it is combined with Etravirine.Approved, Investigational, Vet Approved
PaclitaxelThe serum concentration of Paclitaxel can be decreased when it is combined with Etravirine.Approved, Vet Approved
pafuramidineThe serum concentration of Etravirine can be increased when it is combined with pafuramidine.Investigational
PalbociclibThe serum concentration of Palbociclib can be decreased when it is combined with Etravirine.Approved
PalonosetronThe serum concentration of Palonosetron can be decreased when it is combined with Etravirine.Approved, Investigational
PanobinostatThe serum concentration of Panobinostat can be decreased when it is combined with Etravirine.Approved, Investigational
PantoprazoleThe serum concentration of Pantoprazole can be decreased when it is combined with Etravirine.Approved
ParamethadioneThe serum concentration of Paramethadione can be decreased when it is combined with Etravirine.Approved
ParamethasoneThe serum concentration of Paramethasone can be decreased when it is combined with Etravirine.Approved
ParecoxibThe serum concentration of Parecoxib can be decreased when it is combined with Etravirine.Approved
ParicalcitolThe serum concentration of Paricalcitol can be decreased when it is combined with Etravirine.Approved, Investigational
ParitaprevirThe serum concentration of Paritaprevir can be decreased when it is combined with Etravirine.Approved
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Etravirine.Approved
PentamidineThe serum concentration of Etravirine can be increased when it is combined with Pentamidine.Approved
PentobarbitalThe metabolism of Etravirine can be increased when combined with Pentobarbital.Approved, Vet Approved
PerampanelThe serum concentration of Perampanel can be decreased when it is combined with Etravirine.Approved
PergolideThe serum concentration of Pergolide can be decreased when it is combined with Etravirine.Approved, Vet Approved, Withdrawn
PerhexilineThe serum concentration of Perhexiline can be decreased when it is combined with Etravirine.Approved
PerindoprilThe serum concentration of Etravirine can be decreased when it is combined with Perindopril.Approved
PermethrinThe serum concentration of Permethrin can be decreased when it is combined with Etravirine.Approved, Investigational
PerphenazineThe serum concentration of Perphenazine can be decreased when it is combined with Etravirine.Approved
PethidineThe serum concentration of Pethidine can be decreased when it is combined with Etravirine.Approved
PhenacetinThe serum concentration of Phenacetin can be decreased when it is combined with Etravirine.Withdrawn
PhenobarbitalThe serum concentration of Etravirine can be decreased when it is combined with Phenobarbital.Approved
PhenoxybenzamineThe serum concentration of Phenoxybenzamine can be decreased when it is combined with Etravirine.Approved
PhenprocoumonThe serum concentration of Phenprocoumon can be decreased when it is combined with Etravirine.Approved
PhenylbutazoneThe metabolism of Phenylbutazone can be decreased when combined with Etravirine.Approved, Vet Approved
PhenytoinThe serum concentration of Etravirine can be decreased when it is combined with Phenytoin.Approved, Vet Approved
PhosphoramidonThe serum concentration of Etravirine can be decreased when it is combined with Phosphoramidon.Experimental
PilocarpineThe serum concentration of Pilocarpine can be decreased when it is combined with Etravirine.Approved
PimecrolimusThe serum concentration of Pimecrolimus can be decreased when it is combined with Etravirine.Approved, Investigational
PimozideThe serum concentration of Pimozide can be decreased when it is combined with Etravirine.Approved
PinacidilThe serum concentration of Pinacidil can be decreased when it is combined with Etravirine.Withdrawn
PioglitazoneThe serum concentration of Pioglitazone can be decreased when it is combined with Etravirine.Approved, Investigational
PipotiazineThe serum concentration of Pipotiazine can be decreased when it is combined with Etravirine.Approved
PiroxicamThe metabolism of Piroxicam can be decreased when combined with Etravirine.Approved, Investigational
PitavastatinThe serum concentration of Pitavastatin can be decreased when it is combined with Etravirine.Approved
PodofiloxThe serum concentration of Podofilox can be decreased when it is combined with Etravirine.Approved
PomalidomideThe serum concentration of Pomalidomide can be decreased when it is combined with Etravirine.Approved
PonatinibThe serum concentration of Ponatinib can be decreased when it is combined with Etravirine.Approved
PosaconazoleThe serum concentration of Etravirine can be increased when it is combined with Posaconazole.Approved, Investigational, Vet Approved
PrasteroneThe serum concentration of Prasterone can be decreased when it is combined with Etravirine.Approved, Nutraceutical
PrasugrelThe serum concentration of Prasugrel can be decreased when it is combined with Etravirine.Approved
PravastatinThe serum concentration of Pravastatin can be decreased when it is combined with Etravirine.Approved
PrazepamThe serum concentration of Prazepam can be decreased when it is combined with Etravirine.Approved, Illicit
PraziquantelThe serum concentration of Praziquantel can be decreased when it is combined with Etravirine.Approved, Vet Approved
PrazosinThe serum concentration of Prazosin can be increased when it is combined with Etravirine.Approved
PrednisoloneThe serum concentration of Prednisolone can be decreased when it is combined with Etravirine.Approved, Vet Approved
PrednisoneThe serum concentration of Prednisone can be decreased when it is combined with Etravirine.Approved, Vet Approved
PrimaquineThe serum concentration of Primaquine can be decreased when it is combined with Etravirine.Approved
PrimidoneThe serum concentration of Etravirine can be decreased when it is combined with Primidone.Approved, Vet Approved
PrinomastatThe serum concentration of Etravirine can be decreased when it is combined with Prinomastat.Investigational
ProchlorperazineThe serum concentration of Prochlorperazine can be decreased when it is combined with Etravirine.Approved, Vet Approved
ProgesteroneThe serum concentration of Progesterone can be decreased when it is combined with Etravirine.Approved, Vet Approved
ProguanilThe serum concentration of Proguanil can be decreased when it is combined with Etravirine.Approved
PromazineThe serum concentration of Promazine can be decreased when it is combined with Etravirine.Approved, Vet Approved
PropafenoneThe serum concentration of Propafenone can be decreased when it is combined with Etravirine.Approved
PropofolThe serum concentration of Propofol can be decreased when it is combined with Etravirine.Approved, Investigational, Vet Approved
PropranololThe serum concentration of Propranolol can be decreased when it is combined with Etravirine.Approved, Investigational
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Etravirine.Approved
PyrazinamideThe serum concentration of Pyrazinamide can be decreased when it is combined with Etravirine.Approved
PyrimethamineThe metabolism of Etravirine can be decreased when combined with Pyrimethamine.Approved, Vet Approved
QuazepamThe serum concentration of Quazepam can be decreased when it is combined with Etravirine.Approved, Illicit
QuetiapineThe serum concentration of Quetiapine can be decreased when it is combined with Etravirine.Approved
QuinacrineThe serum concentration of Quinacrine can be decreased when it is combined with Etravirine.Approved
QuinaprilThe serum concentration of Etravirine can be decreased when it is combined with Quinapril.Approved, Investigational
QuinidineThe serum concentration of Quinidine can be decreased when it is combined with Etravirine.Approved
QuinineThe serum concentration of Quinine can be decreased when it is combined with Etravirine.Approved
RabeprazoleThe serum concentration of Rabeprazole can be decreased when it is combined with Etravirine.Approved, Investigational
RacecadotrilThe serum concentration of Etravirine can be decreased when it is combined with Racecadotril.Investigational
RadicicolThe serum concentration of Etravirine can be increased when it is combined with Radicicol.Experimental
RaloxifeneThe serum concentration of Raloxifene can be decreased when it is combined with Etravirine.Approved, Investigational
RamelteonThe serum concentration of Ramelteon can be decreased when it is combined with Etravirine.Approved, Investigational
RamiprilThe serum concentration of Etravirine can be decreased when it is combined with Ramipril.Approved
RanitidineThe serum concentration of Ranitidine can be increased when it is combined with Etravirine.Approved
RanolazineThe serum concentration of Ranolazine can be decreased when it is combined with Etravirine.Approved, Investigational
ReboxetineThe serum concentration of Reboxetine can be decreased when it is combined with Etravirine.Approved, Investigational
RegorafenibThe serum concentration of Regorafenib can be decreased when it is combined with Etravirine.Approved
RemikirenThe serum concentration of Etravirine can be decreased when it is combined with Remikiren.Approved
RepaglinideThe serum concentration of Repaglinide can be decreased when it is combined with Etravirine.Approved, Investigational
ReserpineThe serum concentration of Reserpine can be increased when it is combined with Etravirine.Approved
RetapamulinThe serum concentration of Retapamulin can be decreased when it is combined with Etravirine.Approved
RifabutinThe serum concentration of Etravirine can be decreased when it is combined with Rifabutin.Approved
RifampicinThe serum concentration of Etravirine can be decreased when it is combined with Rifampicin.Approved
RifapentineThe serum concentration of Etravirine can be decreased when it is combined with Rifapentine.Approved
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Etravirine.Approved, Investigational
RilpivirineThe serum concentration of Etravirine can be decreased when it is combined with Rilpivirine.Approved
RimonabantThe serum concentration of Rimonabant can be decreased when it is combined with Etravirine.Approved, Investigational
RiociguatThe serum concentration of Riociguat can be decreased when it is combined with Etravirine.Approved
RisperidoneThe serum concentration of Risperidone can be decreased when it is combined with Etravirine.Approved, Investigational
RitonavirThe serum concentration of Etravirine can be decreased when it is combined with Ritonavir.Approved, Investigational
RivaroxabanThe serum concentration of Etravirine can be decreased when it is combined with Rivaroxaban.Approved
RofecoxibThe serum concentration of Rofecoxib can be decreased when it is combined with Etravirine.Investigational, Withdrawn
RolapitantThe serum concentration of Rolapitant can be decreased when it is combined with Etravirine.Approved
RomidepsinThe serum concentration of Romidepsin can be decreased when it is combined with Etravirine.Approved, Investigational
RopiniroleThe serum concentration of Ropinirole can be decreased when it is combined with Etravirine.Approved, Investigational
RopivacaineThe serum concentration of Ropivacaine can be decreased when it is combined with Etravirine.Approved
RosiglitazoneThe metabolism of Rosiglitazone can be decreased when combined with Etravirine.Approved, Investigational
RosuvastatinThe serum concentration of Rosuvastatin can be decreased when it is combined with Etravirine.Approved
RotigotineThe serum concentration of Rotigotine can be decreased when it is combined with Etravirine.Approved
RoxithromycinThe serum concentration of Roxithromycin can be decreased when it is combined with Etravirine.Approved, Withdrawn
RuxolitinibThe serum concentration of Ruxolitinib can be decreased when it is combined with Etravirine.Approved
Salicylhydroxamic AcidThe serum concentration of Etravirine can be increased when it is combined with Salicylhydroxamic Acid.Experimental
Salicylic acidThe serum concentration of Etravirine can be increased when it is combined with Salicylic acid.Approved, Vet Approved
SalmeterolThe serum concentration of Salmeterol can be decreased when it is combined with Etravirine.Approved
SaquinavirThe serum concentration of Etravirine can be decreased when it is combined with Saquinavir.Approved, Investigational
SaxagliptinThe serum concentration of Saxagliptin can be decreased when it is combined with Etravirine.Approved
SecobarbitalThe metabolism of Etravirine can be increased when combined with Secobarbital.Approved, Vet Approved
SelegilineThe serum concentration of Selegiline can be decreased when it is combined with Etravirine.Approved, Investigational, Vet Approved
SelexipagThe serum concentration of Selexipag can be decreased when it is combined with Etravirine.Approved
SeratrodastThe serum concentration of Seratrodast can be decreased when it is combined with Etravirine.Approved, Investigational
SertaconazoleThe serum concentration of Etravirine can be increased when it is combined with Sertaconazole.Approved
SertindoleThe serum concentration of Sertindole can be decreased when it is combined with Etravirine.Approved, Withdrawn
SertralineThe serum concentration of Sertraline can be decreased when it is combined with Etravirine.Approved
SevofluraneThe serum concentration of Sevoflurane can be decreased when it is combined with Etravirine.Approved, Vet Approved
SibutramineThe serum concentration of Sibutramine can be decreased when it is combined with Etravirine.Approved, Illicit, Investigational, Withdrawn
SildenafilThe serum concentration of Sildenafil can be decreased when it is combined with Etravirine.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Etravirine.Approved
SiltuximabThe serum concentration of Etravirine can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Simeprevir can be decreased when it is combined with Etravirine.Approved
SimvastatinThe serum concentration of Simvastatin can be decreased when it is combined with Etravirine.Approved
SinefunginThe serum concentration of Etravirine can be increased when it is combined with Sinefungin.Experimental
SirolimusThe serum concentration of Etravirine can be increased when it is combined with Sirolimus.Approved, Investigational
SitagliptinThe serum concentration of Etravirine can be decreased when it is combined with Sitagliptin.Approved, Investigational
SitaxentanThe metabolism of Sitaxentan can be decreased when combined with Etravirine.Approved, Investigational, Withdrawn
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Etravirine.Approved
SolifenacinThe serum concentration of Solifenacin can be decreased when it is combined with Etravirine.Approved
SonidegibThe serum concentration of Sonidegib can be decreased when it is combined with Etravirine.Approved, Investigational
SorafenibThe serum concentration of Sorafenib can be decreased when it is combined with Etravirine.Approved, Investigational
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Etravirine.Approved
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Etravirine.Experimental
SpiramycinThe serum concentration of Spiramycin can be decreased when it is combined with Etravirine.Approved
SpiraprilThe serum concentration of Etravirine can be decreased when it is combined with Spirapril.Approved
St. John's WortThe serum concentration of Etravirine can be decreased when it is combined with St. John&#39;s Wort.Nutraceutical
StiripentolThe serum concentration of Etravirine can be increased when it is combined with Stiripentol.Approved
SufentanilThe serum concentration of Sufentanil can be decreased when it is combined with Etravirine.Approved, Investigational
SulconazoleThe serum concentration of Etravirine can be increased when it is combined with Sulconazole.Approved
SulfadiazineThe metabolism of Etravirine can be decreased when combined with Sulfadiazine.Approved, Vet Approved
SulfamethoxazoleThe serum concentration of Sulfamethoxazole can be decreased when it is combined with Etravirine.Approved
SulfamoxoleThe metabolism of Sulfamoxole can be decreased when combined with Etravirine.Approved
SulfinpyrazoneThe serum concentration of Sulfinpyrazone can be decreased when it is combined with Etravirine.Approved
SulfisoxazoleThe metabolism of Etravirine can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
SunitinibThe serum concentration of Sunitinib can be decreased when it is combined with Etravirine.Approved, Investigational
SuprofenThe metabolism of Suprofen can be decreased when combined with Etravirine.Approved, Withdrawn
Synthetic Conjugated Estrogens, AThe serum concentration of Synthetic Conjugated Estrogens, A can be decreased when it is combined with Etravirine.Approved
Synthetic Conjugated Estrogens, BThe serum concentration of Synthetic Conjugated Estrogens, B can be decreased when it is combined with Etravirine.Approved
TacrolimusThe serum concentration of Tacrolimus can be decreased when it is combined with Etravirine.Approved, Investigational
TadalafilThe serum concentration of Tadalafil can be decreased when it is combined with Etravirine.Approved, Investigational
TamoxifenThe serum concentration of Tamoxifen can be decreased when it is combined with Etravirine.Approved
TamsulosinThe serum concentration of Tamsulosin can be decreased when it is combined with Etravirine.Approved, Investigational
TapentadolThe metabolism of Tapentadol can be decreased when combined with Etravirine.Approved
TasosartanThe serum concentration of Tasosartan can be decreased when it is combined with Etravirine.Approved
Taurochenodeoxycholic acidThe serum concentration of Taurochenodeoxycholic acid can be decreased when it is combined with Etravirine.Experimental
Taurocholic AcidThe serum concentration of Taurocholic Acid can be increased when it is combined with Etravirine.Experimental
TavaboroleThe serum concentration of Etravirine can be increased when it is combined with Tavaborole.Approved
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Etravirine.Approved
TelaprevirThe serum concentration of Telaprevir can be decreased when it is combined with Etravirine.Approved
TelithromycinThe metabolism of Etravirine can be decreased when combined with Telithromycin.Approved
TemazepamThe serum concentration of Temazepam can be decreased when it is combined with Etravirine.Approved
TemocaprilThe serum concentration of Etravirine can be decreased when it is combined with Temocapril.Experimental, Investigational
TemsirolimusThe serum concentration of Temsirolimus can be decreased when it is combined with Etravirine.Approved
TeniposideThe serum concentration of Teniposide can be decreased when it is combined with Etravirine.Approved
TenoxicamThe metabolism of Tenoxicam can be decreased when combined with Etravirine.Approved
TerbinafineThe serum concentration of Etravirine can be increased when it is combined with Terbinafine.Approved, Investigational, Vet Approved
TerconazoleThe serum concentration of Etravirine can be increased when it is combined with Terconazole.Approved
TerfenadineThe serum concentration of Terfenadine can be decreased when it is combined with Etravirine.Withdrawn
TesmilifeneThe serum concentration of Tesmilifene can be decreased when it is combined with Etravirine.Investigational
TestosteroneThe serum concentration of Testosterone can be decreased when it is combined with Etravirine.Approved, Investigational
TetracyclineThe serum concentration of Tetracycline can be decreased when it is combined with Etravirine.Approved, Vet Approved
ThalidomideThe metabolism of Thalidomide can be decreased when combined with Etravirine.Approved, Investigational, Withdrawn
TheophyllineThe serum concentration of Theophylline can be decreased when it is combined with Etravirine.Approved
ThiamylalThe metabolism of Thiamylal can be decreased when combined with Etravirine.Approved, Vet Approved
ThioridazineThe metabolism of Thioridazine can be decreased when combined with Etravirine.Approved
ThiorphanThe serum concentration of Etravirine can be decreased when it is combined with Thiorphan.Experimental
ThiotepaThe serum concentration of Thiotepa can be decreased when it is combined with Etravirine.Approved
ThymolThe serum concentration of Etravirine can be increased when it is combined with Thymol.Approved
TiagabineThe serum concentration of Tiagabine can be decreased when it is combined with Etravirine.Approved
TicagrelorThe serum concentration of Ticagrelor can be decreased when it is combined with Etravirine.Approved
TiclopidineThe metabolism of Etravirine can be decreased when combined with Ticlopidine.Approved
TimololThe serum concentration of Timolol can be increased when it is combined with Etravirine.Approved
TinidazoleThe serum concentration of Tinidazole can be decreased when it is combined with Etravirine.Approved, Investigational
TioconazoleThe serum concentration of Etravirine can be increased when it is combined with Tioconazole.Approved
TiotropiumThe serum concentration of Tiotropium can be decreased when it is combined with Etravirine.Approved
TipranavirThe serum concentration of Etravirine can be decreased when it is combined with Tipranavir.Approved, Investigational
TocilizumabThe serum concentration of Etravirine can be decreased when it is combined with Tocilizumab.Approved
TofacitinibThe serum concentration of Tofacitinib can be decreased when it is combined with Etravirine.Approved, Investigational
TolbutamideThe metabolism of Etravirine can be decreased when combined with Tolbutamide.Approved
TolnaftateThe serum concentration of Etravirine can be increased when it is combined with Tolnaftate.Approved, Vet Approved
TolterodineThe serum concentration of Tolterodine can be decreased when it is combined with Etravirine.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be decreased when it is combined with Etravirine.Approved
TopiramateThe metabolism of Etravirine can be decreased when combined with Topiramate.Approved
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Etravirine.Approved, Investigational
TorasemideThe metabolism of Torasemide can be decreased when combined with Etravirine.Approved
ToremifeneThe serum concentration of Toremifene can be decreased when it is combined with Etravirine.Approved, Investigational
TrabectedinThe serum concentration of Trabectedin can be decreased when it is combined with Etravirine.Approved, Investigational
TramadolThe serum concentration of Tramadol can be decreased when it is combined with Etravirine.Approved, Investigational
TrandolaprilThe serum concentration of Etravirine can be decreased when it is combined with Trandolapril.Approved
TranylcypromineThe metabolism of Etravirine can be decreased when combined with Tranylcypromine.Approved
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be decreased when it is combined with Etravirine.Approved
TrazodoneThe serum concentration of Trazodone can be decreased when it is combined with Etravirine.Approved, Investigational
TreprostinilThe metabolism of Treprostinil can be decreased when combined with Etravirine.Approved, Investigational
TretinoinThe serum concentration of Tretinoin can be decreased when it is combined with Etravirine.Approved, Investigational, Nutraceutical
TriamcinoloneThe serum concentration of Triamcinolone can be decreased when it is combined with Etravirine.Approved, Vet Approved
TriazolamThe serum concentration of Triazolam can be decreased when it is combined with Etravirine.Approved
TrimethadioneThe serum concentration of Trimethadione can be decreased when it is combined with Etravirine.Approved
TrimethoprimThe serum concentration of Trimethoprim can be decreased when it is combined with Etravirine.Approved, Vet Approved
TrimetrexateThe serum concentration of Etravirine can be increased when it is combined with Trimetrexate.Approved, Investigational
TrimipramineThe serum concentration of Trimipramine can be decreased when it is combined with Etravirine.Approved
TroglitazoneThe serum concentration of Troglitazone can be decreased when it is combined with Etravirine.Withdrawn
TroleandomycinThe serum concentration of Troleandomycin can be decreased when it is combined with Etravirine.Approved
UbenimexThe serum concentration of Etravirine can be decreased when it is combined with Ubenimex.Experimental
UdenafilThe serum concentration of Udenafil can be decreased when it is combined with Etravirine.Approved, Investigational
UlinastatinThe serum concentration of Etravirine can be decreased when it is combined with Ulinastatin.Investigational
UlipristalThe serum concentration of Ulipristal can be decreased when it is combined with Etravirine.Approved
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Etravirine.Approved
ValdecoxibThe serum concentration of Valdecoxib can be decreased when it is combined with Etravirine.Investigational, Withdrawn
Valproic AcidThe metabolism of Valproic Acid can be decreased when combined with Etravirine.Approved, Investigational
ValsartanThe metabolism of Etravirine can be decreased when combined with Valsartan.Approved, Investigational
VandetanibThe serum concentration of Vandetanib can be decreased when it is combined with Etravirine.Approved
VanoxerineThe serum concentration of Vanoxerine can be decreased when it is combined with Etravirine.Investigational
VardenafilThe serum concentration of Vardenafil can be decreased when it is combined with Etravirine.Approved
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Etravirine.Approved
VemurafenibThe serum concentration of Vemurafenib can be decreased when it is combined with Etravirine.Approved
VenetoclaxThe serum concentration of Venetoclax can be decreased when it is combined with Etravirine.Approved
VenlafaxineThe serum concentration of Venlafaxine can be decreased when it is combined with Etravirine.Approved
VerapamilThe serum concentration of Verapamil can be decreased when it is combined with Etravirine.Approved
VicrivirocThe serum concentration of Vicriviroc can be decreased when it is combined with Etravirine.Investigational
VilanterolThe serum concentration of Vilanterol can be decreased when it is combined with Etravirine.Approved
VilazodoneThe serum concentration of Vilazodone can be decreased when it is combined with Etravirine.Approved
VildagliptinThe serum concentration of Etravirine can be decreased when it is combined with Vildagliptin.Approved, Investigational
VinblastineThe serum concentration of Vinblastine can be decreased when it is combined with Etravirine.Approved
VincristineThe serum concentration of Vincristine can be increased when it is combined with Etravirine.Approved, Investigational
VincristineThe serum concentration of Vincristine can be decreased when it is combined with Etravirine.Approved, Investigational
VindesineThe serum concentration of Vindesine can be decreased when it is combined with Etravirine.Approved
VinorelbineThe serum concentration of Vinorelbine can be decreased when it is combined with Etravirine.Approved, Investigational
VismodegibThe serum concentration of Vismodegib can be decreased when it is combined with Etravirine.Approved
VoriconazoleThe serum concentration of Voriconazole can be decreased when it is combined with Etravirine.Approved, Investigational
VortioxetineThe serum concentration of Vortioxetine can be decreased when it is combined with Etravirine.Approved
WarfarinThe serum concentration of Warfarin can be decreased when it is combined with Etravirine.Approved
XimelagatranThe serum concentration of Etravirine can be decreased when it is combined with Ximelagatran.Approved, Investigational, Withdrawn
Ym150The serum concentration of Etravirine can be decreased when it is combined with Ym150.Investigational
YohimbineThe serum concentration of Yohimbine can be decreased when it is combined with Etravirine.Approved, Vet Approved
ZafirlukastThe serum concentration of Zafirlukast can be decreased when it is combined with Etravirine.Approved, Investigational
ZalcitabineThe serum concentration of Zalcitabine can be decreased when it is combined with Etravirine.Approved
ZaleplonThe serum concentration of Zaleplon can be decreased when it is combined with Etravirine.Approved, Illicit, Investigational
ZaltoprofenThe metabolism of Zaltoprofen can be decreased when combined with Etravirine.Approved
ZidovudineThe serum concentration of Zidovudine can be decreased when it is combined with Etravirine.Approved
ZileutonThe serum concentration of Zileuton can be decreased when it is combined with Etravirine.Approved, Investigational, Withdrawn
ZiprasidoneThe serum concentration of Ziprasidone can be decreased when it is combined with Etravirine.Approved
ZolpidemThe serum concentration of Zolpidem can be decreased when it is combined with Etravirine.Approved
ZomepiracThe serum concentration of Zomepirac can be decreased when it is combined with Etravirine.Withdrawn
ZonisamideThe serum concentration of Zonisamide can be decreased when it is combined with Etravirine.Approved, Investigational
ZopicloneThe serum concentration of Zopiclone can be decreased when it is combined with Etravirine.Approved
Food InteractionsNot Available
References
Synthesis ReferenceNot Available
General ReferencesNot Available
External Links
ATC CodesJ05AG04
AHFS CodesNot Available
PDB Entries
FDA labelDownload (642 KB)
MSDSDownload (122 KB)
ADMET
Predicted ADMET featuresNot Available
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage forms
FormRouteStrength
TabletOral100 mg/1
TabletOral100 mg
TabletOral200 mg/1
TabletOral200 mg
TabletOral25 mg/1
TabletOral25 mg
PricesNot Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2350801 No2008-05-202019-09-24Canada
CA2651665 No2010-04-272027-06-06Canada
US6878717 No1999-11-052019-11-05Us
US7037917 No2000-12-132020-12-13Us
US7887845 No1999-03-252019-03-25Us
US8003789 No1999-11-012019-11-01Us
Properties
StateSolid
Experimental PropertiesNot Available
Predicted Properties
PropertyValueSource
Water Solubility0.0169 mg/mLALOGPS
logP3.67ALOGPS
logP5.54ChemAxon
logS-4.4ALOGPS
pKa (Strongest Acidic)12.49ChemAxon
pKa (Strongest Basic)4.13ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area120.64 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity111.87 m3·mol-1ChemAxon
Polarizability41.09 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as diarylethers. These are organic compounds containing the dialkyl ether functional group, with the formula ROR', where R and R' are aryl groups.
KingdomOrganic compounds
Super ClassOrganooxygen compounds
ClassEthers
Sub ClassDiarylethers
Direct ParentDiarylethers
Alternative Parents
Substituents
  • Diaryl ether
  • Benzonitrile
  • Halopyrimidine
  • Aminopyrimidine
  • Imidolactam
  • Benzenoid
  • Pyrimidine
  • Primary aromatic amine
  • Monocyclic benzene moiety
  • Aryl halide
  • Aryl bromide
  • Heteroaromatic compound
  • Azacycle
  • Organoheterocyclic compound
  • Secondary amine
  • Nitrile
  • Carbonitrile
  • Hydrocarbon derivative
  • Primary amine
  • Organonitrogen compound
  • Organobromide
  • Organohalogen compound
  • Amine
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinducer
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Perez VE, Sanchez-Parra C, Serrano Villar S: [Etravirine drug interactions]. Enferm Infecc Microbiol Clin. 2009 Dec;27 Suppl 2:27-31. doi: 10.1016/S0213-005X(09)73216-1. [PubMed:20116625 ]
  2. Kakuda TN, Scholler-Gyure M, Hoetelmans RM: Pharmacokinetic interactions between etravirine and non-antiretroviral drugs. Clin Pharmacokinet. 2011 Jan;50(1):25-39. doi: 10.2165/11534740-000000000-00000. [PubMed:21142266 ]
  3. Scholler-Gyure M, Kakuda TN, Raoof A, De Smedt G, Hoetelmans RM: Clinical pharmacokinetics and pharmacodynamics of etravirine. Clin Pharmacokinet. 2009;48(9):561-74. doi: 10.2165/10895940-000000000-00000. [PubMed:19725591 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Perez VE, Sanchez-Parra C, Serrano Villar S: [Etravirine drug interactions]. Enferm Infecc Microbiol Clin. 2009 Dec;27 Suppl 2:27-31. doi: 10.1016/S0213-005X(09)73216-1. [PubMed:20116625 ]
  2. Kakuda TN, Scholler-Gyure M, Hoetelmans RM: Pharmacokinetic interactions between etravirine and non-antiretroviral drugs. Clin Pharmacokinet. 2011 Jan;50(1):25-39. doi: 10.2165/11534740-000000000-00000. [PubMed:21142266 ]
  3. Scholler-Gyure M, Kakuda TN, Raoof A, De Smedt G, Hoetelmans RM: Clinical pharmacokinetics and pharmacodynamics of etravirine. Clin Pharmacokinet. 2009;48(9):561-74. doi: 10.2165/10895940-000000000-00000. [PubMed:19725591 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Perez VE, Sanchez-Parra C, Serrano Villar S: [Etravirine drug interactions]. Enferm Infecc Microbiol Clin. 2009 Dec;27 Suppl 2:27-31. doi: 10.1016/S0213-005X(09)73216-1. [PubMed:20116625 ]
  2. Kakuda TN, Scholler-Gyure M, Hoetelmans RM: Pharmacokinetic interactions between etravirine and non-antiretroviral drugs. Clin Pharmacokinet. 2011 Jan;50(1):25-39. doi: 10.2165/11534740-000000000-00000. [PubMed:21142266 ]
  3. Scholler-Gyure M, Kakuda TN, Raoof A, De Smedt G, Hoetelmans RM: Clinical pharmacokinetics and pharmacodynamics of etravirine. Clin Pharmacokinet. 2009;48(9):561-74. doi: 10.2165/10895940-000000000-00000. [PubMed:19725591 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Kakuda TN, Scholler-Gyure M, Hoetelmans RM: Pharmacokinetic interactions between etravirine and non-antiretroviral drugs. Clin Pharmacokinet. 2011 Jan;50(1):25-39. doi: 10.2165/11534740-000000000-00000. [PubMed:21142266 ]
  2. Scholler-Gyure M, Kakuda TN, Raoof A, De Smedt G, Hoetelmans RM: Clinical pharmacokinetics and pharmacodynamics of etravirine. Clin Pharmacokinet. 2009;48(9):561-74. doi: 10.2165/10895940-000000000-00000. [PubMed:19725591 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi of hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi ...
Gene Name:
ABCB4
Uniprot ID:
P21439
Molecular Weight:
141521.845 Da
References
  1. Kakuda TN, Scholler-Gyure M, Hoetelmans RM: Pharmacokinetic interactions between etravirine and non-antiretroviral drugs. Clin Pharmacokinet. 2011 Jan;50(1):25-39. doi: 10.2165/11534740-000000000-00000. [PubMed:21142266 ]
  2. Scholler-Gyure M, Kakuda TN, Raoof A, De Smedt G, Hoetelmans RM: Clinical pharmacokinetics and pharmacodynamics of etravirine. Clin Pharmacokinet. 2009;48(9):561-74. doi: 10.2165/10895940-000000000-00000. [PubMed:19725591 ]
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Drug created on March 19, 2008 10:32 / Updated on December 05, 2016 02:43