Naphthacenes

Polyacenes with four ortho-fused benzene rings in a straight linear arrangement. This group is best known for the subclass called TETRACYCLINES.
DrugDrug NameDrug Indication
DB00254DoxycyclineDoxycycline is indicated for the treatment of various infections by gram-positive and gram-negative bacteria, aerobes and anaerobes, as well other types of bacteria. A complete list of organisms is available in the FDA label and in the "indications" section of this drug entry [FDA label]. The following are some of the major infections that may be treated with doxycycline [FDA label]: Rocky mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsialpox, and tick fevers caused by Rickettsiae Respiratory tract infections caused by Mycoplasma pneumoniae Lymphogranuloma venereum caused by Chlamydia trachomatis Psittacosis (ornithosis) caused by Chlamydia psittaci Trachoma caused by Chlamydia trachomatis, although the infectious agent is not always eliminated as judged by immunofluorescence Inclusion conjunctivitis caused by Chlamydia trachomatis Uncomplicated urethral, endocervical or rectal infections in adults caused by Chlamydia trachomatis Nongonococcal urethritis caused by Ureaplasma urealyticum Relapsing fever due to Borrelia recurrentis **A note regarding anti-microbial resistance** It is important to note that doxycycline is not the drug of choice in the treatment of any type of staphylococcal infection. Up to 44 percent of strains of Streptococcus pyogenes and 74 percent of Streptococcus faecalis have been found to be resistant to tetracyclines. Therefore, tetracyclines such as doxycycline should not be used to treat streptococcal infections unless the microorganism has been demonstrated to be susceptible [FDA label].
DB00256LymecyclineFor the treatment of infections and to treat acne. It may also be used to treat urinary tract infections, gum disease, and other bacterial infections such as gonorrhea and chlamydia. Lymecycline is also used commonly as a prophylactic treatment for infection by Bacillus anthracis (anthrax). It is also effective against Yersinia pestis and malaria and is also prescribed for the treatment of Lyme disease.
DB00385ValrubicinFor the treatment of cancer of the bladder.
DB00445EpirubicinFor use as a component of adjuvant therapy in patients with evidence of axillary node tumor involvement following resection of primary breast cancer.
DB00453ClomocyclineFor the treatment and management of Brucellosis, mycoplasma infection, acne vulgaris, chlamydial infection;Chronic bronchitis
DB00560TigecyclineFor the treatment of infections caused by susceptible strains of the designated microorganisms in the following conditions: Complicated skin and skin structure infections caused by Escherichia coli, Enterococcus faecalis (vancomycin-susceptible isolates only), Staphylococcus aureus (methicillin-susceptible and -resistant isolates), Streptococcus agalactiae, Streptococcus anginosus grp. (includes S. anginosus, S. intermedius, and S. constellatus), Streptococcus pyogenes and Bacteroides fragilis. Complicated intra-abdominal infections caused by Citrobacter freundii, Enterobacter cloacae, Escherichia coli, Klebsiella oxytoca, Klebsiella pneumoniae, Enterococcus faecalis (vancomycin-susceptible isolates only), Staphylococcus aureus (methicillin-susceptible isolates only), Streptococcus anginosus grp. (includes S. anginosus, S. intermedius, and S. constellatus), Bacteroides fragilis, Bacteroides thetaiotaomicron, Bacteroides uniformis, Bacteroides vulgatus, Clostridium perfringens, and Peptostreptococcus micros.
DB00595OxytetracyclineOxytetracycline is indicated for treatment of infections caused by a variety of Gram positive and Gram negative microorganisms including Mycoplasma pneumoniae, Pasteurella pestis, Escherichia coli, Haemophilus influenzae (respiratory infections), and Diplococcus pneumoniae.
DB00618DemeclocyclineUsed primarily to treat Lyme disease, acne, and bronchitis. Also indicated (but rarely used) to treat urinary tract infections, gum disease, malaria, and other bacterial infections such as gonorrhea and chlamydia. One of its other registered uses is the treatment of hyponatremia (low blood sodium concentration) due to the syndrome of inappropriate antidiuretic hormone (SIADH) where fluid restriction alone has been ineffective.
DB00694DaunorubicinFor remission induction in acute nonlymphocytic leukemia (myelogenous, monocytic, erythroid) of adults and for remission induction in acute lymphocytic leukemia of children and adults.
DB00759TetracyclineUsed to treat bacterial infections such as Rocky Mountain spotted fever, typhus fever, tick fevers, Q fever, rickettsialpox and Brill-Zinsser disease. May be used to treat infections caused by Chlamydiae spp., B. burgdorferi (Lyme disease), and upper respiratory infections caused by typical (S. pneumoniae, H. influenzae, and M. catarrhalis) and atypical organisms (C. pneumoniae, M. pneumoniae, L. pneumophila). May also be used to treat acne. Tetracycline may be an alternative drug for people who are allergic to penicillin.
DB00931MetacyclineFor the treatment of acute bacterial exacerbations of chronic bronchitis
DB00997DoxorubicinDoxorubicin is used to produce regression in disseminated neoplastic conditions like acute lymphoblastic leukemia, acute myeloblastic leukemia, Wilms’ tumor, neuroblastoma, soft tissue and bone sarcomas, breast carcinoma, ovarian carcinoma, transitional cell bladder carcinoma, thyroid carcinoma, gastric carcinoma, Hodgkin’s disease, malignant lymphoma and bronchogenic carcinoma in which the small cell histologic type is the most responsive compared to other cell types. Doxorubicin is also indicated for use as a component of adjuvant therapy in women with evidence of axillary lymph node involvement following resection of primary breast cancer.
DB01017MinocyclineFor the treatment of infections caused by susceptible strains of microorganisms, such as Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsial pox and tick fevers caused by Rickettsiae, upper respiratory tract infections caused by Streptococcus pneumoniae and for the treatment of asymptomatic carriers of Neisseria meningitidis.
DB01177IdarubicinFor the treatment of acute myeloid leukemia (AML) in adults. This includes French-American-British (FAB) classifications M1 through M7.
DB01301RolitetracyclineRolitetracycline is a broad-spectrum antibiotic used in cases needing high concentrations or when oral administration is impractical.
DB04978SP1049CIntended for the treatment of carcinoma of the oesophagus.
DB06013AldoxorubicinInvestigated for use/treatment in solid tumors.
DB06263AmrubicinInvestigated for use/treatment in lung cancer [A4138].
DB06420AnnamycinInvestigated for use/treatment in breast cancer and leukemia (unspecified).
DB06810PlicamycinFor the treatment of testicular cancer, as well as hypercalcemia and hypercalciuria associated with a variety of advanced forms of cancer.
DB09093ChlortetracyclineUsed in the manufacuring of medicated animal feeds [FDA Label].
DB11616PirarubicinNot Available
DB11617AclarubicinNot Available
DB11618ZorubicinNot Available
DB12329EravacyclineThis drug is a tetracycline class antibacterial indicated for the treatment of complicated intra-abdominal infections in patients 18 years of age and older [FDA label].
DB12410SabarubicinNot Available
DB12455OmadacyclineOmadacycline is indicated for the treatment of community acquired bacterial pneumonia and acute bacterial skin and skin structure infections caused by omadacycline-susceptible organisms in adults.[FDA Label]
DB12755Zoptarelin doxorubicinNot Available
DB13103GPX-150Not Available
DB13264PenimepicyclineNot Available
DB13092MeclocyclineCurrently under investigation for the topical treatment of ulcerative oral mucositis [L797]
DB06071DTS-201Investigated for use/treatment in cancer/tumors (unspecified).
DB12035SarecyclineSarecycline is a tetracycline-class drug indicated for the treatment of inflammatory lesions of non-nodular moderate to severe acne vulgaris in patients 9 years of age and older [FDA Label].
DB14784GancotamabNot Available
DB15040TP-271Not Available
DrugDrug NameTargetType
DB00254Doxycycline16S rRNAtarget
DB00254DoxycyclineSolute carrier family 22 member 6transporter
DB00254DoxycyclineCytochrome P450 3A4enzyme
DB00254DoxycyclineATP-binding cassette sub-family B member 5transporter
DB00256Lymecycline30S ribosomal protein S4target
DB00256Lymecycline30S ribosomal protein S9target
DB00385ValrubicinDNA topoisomerase 2-alphatarget
DB00385ValrubicinDNAtarget
DB00445EpirubicinChromodomain-helicase-DNA-binding protein 1target
DB00445EpirubicinDNA topoisomerase 2-alphatarget
DB00445EpirubicinDNAtarget
DB00445EpirubicinMultidrug resistance-associated protein 1transporter
DB00445EpirubicinUDP-glucuronosyltransferase 2B7enzyme
DB00445EpirubicinCytosolic phospholipase A2enzyme
DB00453Clomocycline30S ribosomal protein S4target
DB00453Clomocycline30S ribosomal protein S9target
DB00453Clomocycline16S rRNAtarget
DB00560Tigecycline30S ribosomal protein S9target
DB00560Tigecycline16S rRNAtarget
DB00560Tigecycline30S ribosomal protein S14target
DB00560Tigecycline30S ribosomal protein S13target
DB00560Tigecycline30S ribosomal protein S19target
DB00560Tigecycline30S ribosomal protein S12target
DB00595Oxytetracycline30S ribosomal protein S4target
DB00595Oxytetracycline30S ribosomal protein S9target
DB00595Oxytetracycline16S rRNAtarget
DB00595OxytetracyclineSolute carrier family 22 member 6transporter
DB00595OxytetracyclineSolute carrier family 22 member 8transporter
DB00595OxytetracyclineSolute carrier family 22 member 11transporter
DB00595OxytetracyclineSolute carrier family 22 member 7transporter
DB00618Demeclocycline30S ribosomal protein S4target
DB00618Demeclocycline30S ribosomal protein S9target
DB00694DaunorubicinDNAtarget
DB00694DaunorubicinXanthine dehydrogenase/oxidaseenzyme
DB00694DaunorubicinCytochrome P450 3A5enzyme
DB00694DaunorubicinNADPH--cytochrome P450 reductaseenzyme
DB00694DaunorubicinMultidrug resistance protein 1transporter
DB00694DaunorubicinMultidrug resistance-associated protein 1transporter
DB00694DaunorubicinCanalicular multispecific organic anion transporter 1transporter
DB00694DaunorubicinMultidrug resistance-associated protein 6transporter
DB00694DaunorubicinBile salt export pumptransporter
DB00694DaunorubicinMultidrug resistance-associated protein 7transporter
DB00694DaunorubicinATP-binding cassette sub-family G member 2transporter
DB00694DaunorubicinDNA topoisomerase 2-alphatarget
DB00694DaunorubicinDNA topoisomerase 2-betatarget
DB00694DaunorubicinCytochrome P450 1A1enzyme
DB00694DaunorubicinCytochrome P450 1B1enzyme
DB00694DaunorubicinCytochrome P450 3A4enzyme
DB00759Tetracycline16S rRNAtarget
DB00759TetracyclineMajor prion proteintarget
DB00759TetracyclineSerum albumincarrier
DB00759TetracyclineCytochrome P450 3A4enzyme
DB00759TetracyclineSolute carrier family 22 member 6transporter
DB00759TetracyclineSolute carrier family 22 member 8transporter
DB00759TetracyclineSolute carrier family 22 member 11transporter
DB00759TetracyclineSolute carrier family 22 member 7transporter
DB00759Tetracycline30S ribosomal protein S3target
DB00759Tetracycline30S ribosomal protein S8target
DB00759Tetracycline30S ribosomal protein S19target
DB00759Tetracycline30S ribosomal protein S14target
DB00759Tetracycline30S ribosomal protein S7target
DB00759TetracyclineMultidrug translocase MdfAtarget
DB00759TetracyclineProtein-arginine deiminase type-4target
DB00759TetracyclineSolute carrier organic anion transporter family member 2B1transporter
DB00931MetacyclineSerum albumincarrier
DB00931Metacycline16S rRNAtarget
DB00997DoxorubicinDNA topoisomerase 2-alphatarget
DB00997DoxorubicinDNAtarget
DB00997DoxorubicinCytochrome P450 3A4enzyme
DB00997DoxorubicinCytochrome P450 2D6enzyme
DB00997DoxorubicinCytochrome P450 2B6enzyme
DB00997DoxorubicinMultidrug resistance protein 1transporter
DB00997DoxorubicinCanalicular multispecific organic anion transporter 2transporter
DB00997DoxorubicinMultidrug resistance-associated protein 6transporter
DB00997DoxorubicinMultidrug resistance-associated protein 1transporter
DB00997DoxorubicinMultidrug resistance-associated protein 7transporter
DB00997DoxorubicinATP-binding cassette sub-family G member 2transporter
DB00997DoxorubicinBile salt export pumptransporter
DB00997DoxorubicinSolute carrier family 22 member 16transporter
DB00997DoxorubicinATP-binding cassette sub-family B member 8, mitochondrialtransporter
DB00997DoxorubicinCytochrome P450 1B1enzyme
DB00997DoxorubicinCarbonyl reductase [NADPH] 1enzyme
DB00997DoxorubicinCarbonyl reductase [NADPH] 3enzyme
DB00997DoxorubicinAlcohol dehydrogenase [NADP(+)]enzyme
DB00997DoxorubicinAldo-keto reductase family 1 member C3enzyme
DB00997DoxorubicinNAD(P)H dehydrogenase [quinone] 1enzyme
DB00997DoxorubicinXanthine dehydrogenase/oxidaseenzyme
DB00997DoxorubicinNitric oxide synthase, endothelialenzyme
DB00997DoxorubicinNitric oxide synthase, inducibleenzyme
DB00997DoxorubicinNitric oxide synthase, brainenzyme
DB00997DoxorubicinNADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrialenzyme
DB00997DoxorubicinNADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrialenzyme
DB00997DoxorubicinNADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrialenzyme
DB00997DoxorubicinNADPH--cytochrome P450 reductaseenzyme
DB00997DoxorubicinRalA-binding protein 1transporter
DB00997DoxorubicinCanalicular multispecific organic anion transporter 1transporter
DB00997DoxorubicinSerum albumincarrier
DB00997DoxorubicinNucleolar and coiled-body phosphoprotein 1target
DB01017Minocycline30S ribosomal protein S4target
DB01017Minocycline30S ribosomal protein S9target
DB01017Minocycline16S rRNAtarget
DB01017MinocyclineInterleukin-1 betatarget
DB01017MinocyclineArachidonate 5-lipoxygenasetarget
DB01017MinocyclineMatrix metalloproteinase-9target
DB01017MinocyclineVascular endothelial growth factor Atarget
DB01017MinocyclineCaspase-1target
DB01017MinocyclineCaspase-3target
DB01017MinocyclineCytochrome ctarget
DB01017MinocyclineSolute carrier family 22 member 6transporter
DB01017MinocyclineSolute carrier family 22 member 8transporter
DB01017MinocyclineSolute carrier family 22 member 11transporter
DB01017MinocyclineSolute carrier family 22 member 7transporter
DB01177IdarubicinDNA topoisomerase 2-alphatarget
DB01177IdarubicinDNAtarget
DB01177IdarubicinMultidrug resistance-associated protein 1transporter
DB01177IdarubicinCytochrome P450 2C9enzyme
DB01177IdarubicinCytochrome P450 2D6enzyme
DB01301Rolitetracycline30S ribosomal protein S9target
DB01301Rolitetracycline16S rRNAtarget
DB04978SP1049CDNA topoisomerase 2-alphatarget
DB06013AldoxorubicinDNA topoisomerase 2-alphatarget
DB06263AmrubicinDNA topoisomerase 2-alphatarget
DB06263AmrubicinDNAtarget
DB06263AmrubicinNADPH--cytochrome P450 reductaseenzyme
DB06263AmrubicinCarbonyl reductase [NADPH] 1enzyme
DB06263AmrubicinATP-binding cassette sub-family B member 5transporter
DB06420AnnamycinDNA topoisomerase 2-alphatarget
DB06420AnnamycinDNAtarget
DB06810PlicamycinDNAtarget
DB09093Chlortetracycline16S rRNAtarget
DB09093ChlortetracyclineSerum albumincarrier
DB09093Chlortetracycline30S ribosomal protein S3target
DB09093Chlortetracycline30S ribosomal protein S8target
DB09093Chlortetracycline30S ribosomal protein S19target
DB09093Chlortetracycline30S ribosomal protein S14target
DB09093Chlortetracycline30S ribosomal protein S7target
DB12329EravacyclineCytochrome P450 3A4enzyme
DB12329EravacyclineAmine oxidase [flavin-containing] Aenzyme
DB12329Eravacycline30S ribosomal protein S4target
DB12455OmadacyclineMultidrug resistance protein 1transporter
DB12455Omadacycline30S ribosomal protein S3target
DB12455Omadacycline30S ribosomal protein S7target
DB12455Omadacycline30S ribosomal protein S8target
DB12455Omadacycline30S ribosomal protein S19target
DB12455Omadacycline30S ribosomal protein S14target
DB12455Omadacycline16S rRNAtarget
DB12455OmadacyclineSerum albumincarrier
DB13092MeclocyclineOuter membrane protein Ftransporter
DB13092MeclocyclineOuter membrane porin Ctransporter
DB13092Meclocycline30S ribosomal protein S7target
DB13092MeclocyclineTetX family tetracycline inactivation enzymeenzyme
DB12035SarecyclineMultidrug resistance protein 1transporter
DB12035Sarecycline70S ribosometarget