Naphthacenes

Polyacenes with four ortho-fused benzene rings in a straight linear arrangement. This group is best known for the subclass called TETRACYCLINES.
DrugDrug NameDrug Description
DB00254DoxycyclineA tetracycline antibiotic used to treat a wide variety of bacterial infections.
DB00256LymecyclineFor the treatment of infections and to treat acne. It may also be used to treat urinary tract infections, gum disease, and other bacterial infections such as gonorrhea and chlamydia....
DB00385ValrubicinAn anthracycline used intravesically in the treatment of BCG-resistant bladder carcinoma.
DB00445EpirubicinAn anthracycline topoisomerase II inhibitor used as an adjuvant to treating axillary node metastases in patients who have undergone surgical resection of primary breast cancer.
DB00453ClomocyclineFor the treatment and management of Brucellosis, mycoplasma infection, acne vulgaris, chlamydial infection;Chronic bronchitis
DB00560TigecyclineA glycylcycline antibiotic used to treat a number of susceptible bacterial infections.
DB00595OxytetracyclineA tetracycline antibiotic used to treat a wide variety of susceptible bacterial infections.
DB00618DemeclocyclineA tetracycline antibiotic used to treat a wide variety of susceptible bacterial infections.
DB00694DaunorubicinAn anthracycline aminoglycoside used to induce remission of nonlymphocytic leukemia and acute lymphocytic leukemia.
DB00759TetracyclineAn antibiotic used to treat a wide variety of susceptible infections.
DB00931MetacyclineFor the treatment of acute bacterial exacerbations of chronic bronchitis
DB00997DoxorubicinA medication used to treat various cancers and Kaposi's Sarcoma.
DB01017MinocyclineA tetracycline analog used to treat a wide variety of infections in the body.
DB01177IdarubicinAn anthracycline antineoplastic agent used to treat acute myeloid leukemia (AML) in adults.
DB01301RolitetracyclineA broad-spectrum tetracycline antibiotic used in cases needing high concentrations or when oral administration is impractical.
DB04978SP1049CIntended for the treatment of carcinoma of the oesophagus.
DB06013AldoxorubicinInvestigated for use/treatment in solid tumors.
DB06263AmrubicinInvestigated for use/treatment in lung cancer .
DB06420AnnamycinInvestigated for use/treatment in breast cancer and leukemia (unspecified).
DB06810PlicamycinFor the treatment of testicular cancer, as well as hypercalcemia and hypercalciuria associated with a variety of advanced forms of cancer.
DB09093ChlortetracyclineThe first tetracycline antibiotic most commonly used for veterinary purposes.
DB11616PirarubicinNot Annotated
DB11617AclarubicinNot Annotated
DB11618ZorubicinZorubicin is a drug of the anthracycline class - a class of medications that have historically demonstrated effective chemotherapy for a variety of cancer types.
DB12329EravacyclineA tetracycline antibiotic used to treat complicated intra-abdominal infections.
DB12410SabarubicinSabarubicin has been used in trials studying the treatment of Prostate Cancer, Testicular Germ Cell Tumor, and Unspecified Adult Solid Tumor, Protocol Specific.
DB12455OmadacyclineA tetracycline antibiotic used to treat community acquired bacterial pneumonia.
DB12755Zoptarelin doxorubicinZoptarelin doxorubicin has been used in trials studying the treatment of Breast Cancer, Ovarian Cancer, Prostate Cancer, Endometrial Cancer, and Urothelial Carcinoma, among others.
DB13103GPX-150GPX-150 has been used in trials studying the treatment of Soft Tissue Sarcoma and Advanced Solid Tumors - Phase 1 Population.
DB13264PenimepicyclinePenimepicycline is a tetracycline-class antibiotic. It is mentioned on List A produced by the Government of Canada, which is a list of antimicrobial active pharmaceutical ingredients . In the classification...
DB13092MeclocyclineCurrently under investigation for the topical treatment of ulcerative oral mucositis
DB06071DTS-201Investigated for use/treatment in cancer/tumors (unspecified).
DB12035SarecyclineA tetracycline antibiotic used to treat inflammatory lesions of non-nodular moderate to severe acne vulgaris.
DB14784GancotamabGancotamab is under investigation in clinical trial NCT02213744 (MM-302 Plus Trastuzumab vs. Chemotherapy of Physician's Choice Plus Trastuzumab in HER2-Positive Locally Advanced/Metastatic Breast Cancer Patients).
DB15040TP-271TP-271 is under investigation in clinical trial NCT02724085 (A Phase 1 Study to Assess the Safety, Tolerability and PK of IV TP-271).
DB11647IncyclinideIncyclinide has been used in trials studying the treatment of HIV Infection, AIDS-related Kaposi Sarcoma, Brain and Central Nervous System Tumors, and Unspecified Adult Solid Tumor, Protocol Specific.
DrugDrug NameTargetType
DB00254Doxycycline16S ribosomal RNAtarget
DB00254DoxycyclineSolute carrier family 22 member 6transporter
DB00254DoxycyclineCytochrome P450 3A4enzyme
DB00254DoxycyclineATP-binding cassette sub-family B member 5transporter
DB00256Lymecycline30S ribosomal protein S4target
DB00256Lymecycline30S ribosomal protein S9target
DB00385ValrubicinDNA topoisomerase 2-alphatarget
DB00385ValrubicinDNAtarget
DB00445EpirubicinChromodomain-helicase-DNA-binding protein 1target
DB00445EpirubicinDNA topoisomerase 2-alphatarget
DB00445EpirubicinDNAtarget
DB00445EpirubicinMultidrug resistance-associated protein 1transporter
DB00445EpirubicinUDP-glucuronosyltransferase 2B7enzyme
DB00445EpirubicinCytosolic phospholipase A2enzyme
DB00453Clomocycline30S ribosomal protein S4target
DB00453Clomocycline30S ribosomal protein S9target
DB00453Clomocycline16S ribosomal RNAtarget
DB00560Tigecycline30S ribosomal protein S9target
DB00560Tigecycline16S ribosomal RNAtarget
DB00560Tigecycline30S ribosomal protein S14target
DB00560Tigecycline30S ribosomal protein S13target
DB00560Tigecycline30S ribosomal protein S19target
DB00560Tigecycline30S ribosomal protein S12target
DB00595Oxytetracycline30S ribosomal protein S4target
DB00595Oxytetracycline30S ribosomal protein S9target
DB00595Oxytetracycline16S ribosomal RNAtarget
DB00595OxytetracyclineSolute carrier family 22 member 6transporter
DB00595OxytetracyclineSolute carrier family 22 member 8transporter
DB00595OxytetracyclineSolute carrier family 22 member 11transporter
DB00595OxytetracyclineSolute carrier family 22 member 7transporter
DB00618Demeclocycline30S ribosomal protein S4target
DB00618Demeclocycline30S ribosomal protein S9target
DB00694DaunorubicinDNAtarget
DB00694DaunorubicinXanthine dehydrogenase/oxidaseenzyme
DB00694DaunorubicinCytochrome P450 3A5enzyme
DB00694DaunorubicinNADPH--cytochrome P450 reductaseenzyme
DB00694DaunorubicinP-glycoprotein 1transporter
DB00694DaunorubicinMultidrug resistance-associated protein 1transporter
DB00694DaunorubicinCanalicular multispecific organic anion transporter 1transporter
DB00694DaunorubicinMultidrug resistance-associated protein 6transporter
DB00694DaunorubicinBile salt export pumptransporter
DB00694DaunorubicinMultidrug resistance-associated protein 7transporter
DB00694DaunorubicinATP-binding cassette sub-family G member 2transporter
DB00694DaunorubicinDNA topoisomerase 2-alphatarget
DB00694DaunorubicinDNA topoisomerase 2-betatarget
DB00694DaunorubicinCytochrome P450 1A1enzyme
DB00694DaunorubicinCytochrome P450 1B1enzyme
DB00694DaunorubicinCytochrome P450 3A4enzyme
DB00759Tetracycline16S ribosomal RNAtarget
DB00759TetracyclineMajor prion proteintarget
DB00759TetracyclineSerum albumincarrier
DB00759TetracyclineCytochrome P450 3A4enzyme
DB00759TetracyclineSolute carrier family 22 member 6transporter
DB00759TetracyclineSolute carrier family 22 member 8transporter
DB00759TetracyclineSolute carrier family 22 member 11transporter
DB00759TetracyclineSolute carrier family 22 member 7transporter
DB00759Tetracycline30S ribosomal protein S3target
DB00759Tetracycline30S ribosomal protein S8target
DB00759Tetracycline30S ribosomal protein S19target
DB00759Tetracycline30S ribosomal protein S14target
DB00759Tetracycline30S ribosomal protein S7target
DB00759TetracyclineMultidrug translocase MdfAtarget
DB00759TetracyclineProtein-arginine deiminase type-4target
DB00759TetracyclineSolute carrier organic anion transporter family member 2B1transporter
DB00931MetacyclineSerum albumincarrier
DB00931Metacycline16S ribosomal RNAtarget
DB00997DoxorubicinDNA topoisomerase 2-alphatarget
DB00997DoxorubicinDNAtarget
DB00997DoxorubicinCytochrome P450 3A4enzyme
DB00997DoxorubicinCytochrome P450 2D6enzyme
DB00997DoxorubicinCytochrome P450 2B6enzyme
DB00997DoxorubicinP-glycoprotein 1transporter
DB00997DoxorubicinCanalicular multispecific organic anion transporter 2transporter
DB00997DoxorubicinMultidrug resistance-associated protein 6transporter
DB00997DoxorubicinMultidrug resistance-associated protein 1transporter
DB00997DoxorubicinMultidrug resistance-associated protein 7transporter
DB00997DoxorubicinATP-binding cassette sub-family G member 2transporter
DB00997DoxorubicinBile salt export pumptransporter
DB00997DoxorubicinSolute carrier family 22 member 16transporter
DB00997DoxorubicinATP-binding cassette sub-family B member 8, mitochondrialtransporter
DB00997DoxorubicinCytochrome P450 1B1enzyme
DB00997DoxorubicinCarbonyl reductase [NADPH] 1enzyme
DB00997DoxorubicinCarbonyl reductase [NADPH] 3enzyme
DB00997DoxorubicinAlcohol dehydrogenase [NADP(+)]enzyme
DB00997DoxorubicinAldo-keto reductase family 1 member C3enzyme
DB00997DoxorubicinNAD(P)H dehydrogenase [quinone] 1enzyme
DB00997DoxorubicinXanthine dehydrogenase/oxidaseenzyme
DB00997DoxorubicinNitric oxide synthase, endothelialenzyme
DB00997DoxorubicinNitric oxide synthase, inducibleenzyme
DB00997DoxorubicinNitric oxide synthase, brainenzyme
DB00997DoxorubicinNADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrialenzyme
DB00997DoxorubicinNADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrialenzyme
DB00997DoxorubicinNADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrialenzyme
DB00997DoxorubicinNADPH--cytochrome P450 reductaseenzyme
DB00997DoxorubicinRalA-binding protein 1transporter
DB00997DoxorubicinCanalicular multispecific organic anion transporter 1transporter
DB00997DoxorubicinSerum albumincarrier
DB00997DoxorubicinNucleolar and coiled-body phosphoprotein 1target
DB01017Minocycline30S ribosomal protein S4target
DB01017Minocycline30S ribosomal protein S9target
DB01017Minocycline16S ribosomal RNAtarget
DB01017MinocyclineInterleukin-1 betatarget
DB01017MinocyclineArachidonate 5-lipoxygenasetarget
DB01017MinocyclineMatrix metalloproteinase-9target
DB01017MinocyclineVascular endothelial growth factor Atarget
DB01017MinocyclineCaspase-1target
DB01017MinocyclineCaspase-3target
DB01017MinocyclineCytochrome ctarget
DB01017MinocyclineSolute carrier family 22 member 6transporter
DB01017MinocyclineSolute carrier family 22 member 8transporter
DB01017MinocyclineSolute carrier family 22 member 11transporter
DB01017MinocyclineSolute carrier family 22 member 7transporter
DB01177IdarubicinDNA topoisomerase 2-alphatarget
DB01177IdarubicinDNAtarget
DB01177IdarubicinMultidrug resistance-associated protein 1transporter
DB01177IdarubicinCytochrome P450 2C9enzyme
DB01177IdarubicinCytochrome P450 2D6enzyme
DB01301Rolitetracycline30S ribosomal protein S9target
DB01301Rolitetracycline16S ribosomal RNAtarget
DB04978SP1049CDNA topoisomerase 2-alphatarget
DB06013AldoxorubicinDNA topoisomerase 2-alphatarget
DB06263AmrubicinDNA topoisomerase 2-alphatarget
DB06263AmrubicinDNAtarget
DB06263AmrubicinNADPH--cytochrome P450 reductaseenzyme
DB06263AmrubicinCarbonyl reductase [NADPH] 1enzyme
DB06263AmrubicinATP-binding cassette sub-family B member 5transporter
DB06420AnnamycinDNA topoisomerase 2-alphatarget
DB06420AnnamycinDNAtarget
DB06810PlicamycinDNAtarget
DB09093Chlortetracycline16S ribosomal RNAtarget
DB09093ChlortetracyclineSerum albumincarrier
DB09093Chlortetracycline30S ribosomal protein S3target
DB09093Chlortetracycline30S ribosomal protein S8target
DB09093Chlortetracycline30S ribosomal protein S19target
DB09093Chlortetracycline30S ribosomal protein S14target
DB09093Chlortetracycline30S ribosomal protein S7target
DB12329EravacyclineCytochrome P450 3A4enzyme
DB12329EravacyclineAmine oxidase [flavin-containing] Aenzyme
DB12329Eravacycline30S ribosomal protein S4target
DB12455OmadacyclineP-glycoprotein 1transporter
DB12455Omadacycline30S ribosomal protein S3target
DB12455Omadacycline30S ribosomal protein S7target
DB12455Omadacycline30S ribosomal protein S8target
DB12455Omadacycline30S ribosomal protein S19target
DB12455Omadacycline30S ribosomal protein S14target
DB12455Omadacycline16S ribosomal RNAtarget
DB12455OmadacyclineSerum albumincarrier
DB13092MeclocyclineOuter membrane protein Ftransporter
DB13092MeclocyclineOuter membrane porin Ctransporter
DB13092Meclocycline30S ribosomal protein S7target
DB13092MeclocyclineTetX family tetracycline inactivation enzymeenzyme
DB12035SarecyclineP-glycoprotein 1transporter