Annamycin

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Annamycin
Accession Number
DB06420
Type
Small Molecule
Groups
Investigational
Description
Not Available
Structure
Thumb
Synonyms
  • AR-522
Categories
UNII
SNU299M83Q
CAS number
92689-49-1
Weight
Average: 640.379
Monoisotopic: 640.04416
Chemical Formula
C26H25IO11
InChI Key
CIDNKDMVSINJCG-GKXONYSUSA-N
InChI
InChI=1S/C26H25IO11/c1-9-19(30)24(35)18(27)25(37-9)38-13-7-26(36,14(29)8-28)6-12-15(13)23(34)17-16(22(12)33)20(31)10-4-2-3-5-11(10)21(17)32/h2-5,9,13,18-19,24-25,28,30,33-36H,6-8H2,1H3/t9-,13-,18+,19-,24-,25-,26-/m0/s1
IUPAC Name
(7S,9S)-7-{[(2R,3R,4R,5R,6S)-4,5-dihydroxy-3-iodo-6-methyloxan-2-yl]oxy}-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-5,7,8,9,10,12-hexahydrotetracene-5,12-dione
SMILES
C[[email protected]@H]1O[[email protected]@H](O[[email protected]]2C[[email protected]@](O)(CC3=C2C(O)=C2C(=O)C4=CC=CC=C4C(=O)C2=C3O)C(=O)CO)[[email protected]](I)[[email protected]](O)[[email protected]]1O

Pharmacology

Indication

Investigated for use/treatment in breast cancer and leukemia (unspecified).

Structured Indications
Not Available
Pharmacodynamics
Not Available
Mechanism of action

Annamycin belongs to the anthracycline class of drugs, and has a pleiotropic mechanism of action where it targets topoisomerase II, causing strand breaks in DNA. Annamycin forms complexes with DNA by intercalation between base pairs, and it inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the ligation-religation reaction that topoisomerase II catalyzes.

TargetActionsOrganism
UDNA topoisomerase 2-alphaNot AvailableHuman
UDNANot AvailableHuman
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
AceclofenacAceclofenac may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved, Investigational
AcemetacinAcemetacin may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved, Experimental, Investigational
AcetyldigitoxinAcetyldigitoxin may decrease the cardiotoxic activities of Annamycin.Approved
AcetyldigoxinAcetyldigoxin may decrease the cardiotoxic activities of Annamycin.Experimental
Acetylsalicylic acidAcetylsalicylic acid may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved, Vet Approved
AdapaleneAdapalene may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved
AlclofenacAlclofenac may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved, Withdrawn
AlcuroniumAnnamycin may increase the respiratory depressant activities of Alcuronium.Experimental
Alendronic acidAnnamycin may increase the hypocalcemic activities of Alendronic acid.Approved
AlminoprofenAlminoprofen may decrease the excretion rate of Annamycin which could result in a higher serum level.Experimental
AmdinocillinThe serum concentration of Annamycin can be decreased when it is combined with Amdinocillin.Investigational, Withdrawn
AmoxicillinThe serum concentration of Annamycin can be decreased when it is combined with Amoxicillin.Approved, Vet Approved
Amphotericin BAmphotericin B may increase the nephrotoxic activities of Annamycin.Approved, Investigational
AmpicillinThe serum concentration of Annamycin can be decreased when it is combined with Ampicillin.Approved, Vet Approved
AncestimThe risk or severity of cytotoxicity can be increased when Ancestim is combined with Annamycin.Approved, Investigational, Withdrawn
AndrographolideAndrographolide may decrease the excretion rate of Annamycin which could result in a higher serum level.Investigational
AnisodamineAnisodamine may decrease the excretion rate of Annamycin which could result in a higher serum level.Investigational
AntipyrineAntipyrine may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved
ApocyninApocynin may decrease the excretion rate of Annamycin which could result in a higher serum level.Investigational
ApremilastApremilast may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved, Investigational
AspoxicillinThe serum concentration of Annamycin can be decreased when it is combined with Aspoxicillin.Experimental
AtracuriumAnnamycin may increase the respiratory depressant activities of Atracurium.Experimental, Investigational
Atracurium besylateAnnamycin may increase the respiratory depressant activities of Atracurium besylate.Approved
AzapropazoneAzapropazone may decrease the excretion rate of Annamycin which could result in a higher serum level.Withdrawn
AzelastineAzelastine may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved
AzidocillinThe serum concentration of Annamycin can be decreased when it is combined with Azidocillin.Approved
AzlocillinThe serum concentration of Annamycin can be decreased when it is combined with Azlocillin.Approved
BacampicillinThe serum concentration of Annamycin can be decreased when it is combined with Bacampicillin.Approved, Investigational
BalsalazideBalsalazide may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved, Investigational
BendazacBendazac may decrease the excretion rate of Annamycin which could result in a higher serum level.Experimental
BenorilateBenorilate may decrease the excretion rate of Annamycin which could result in a higher serum level.Experimental
BenoxaprofenBenoxaprofen may decrease the excretion rate of Annamycin which could result in a higher serum level.Withdrawn
Benzathine benzylpenicillinThe serum concentration of Annamycin can be decreased when it is combined with Benzathine benzylpenicillin.Approved, Vet Approved
BenzydamineBenzydamine may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved
BenzylpenicillinThe serum concentration of Annamycin can be decreased when it is combined with Benzylpenicillin.Approved, Vet Approved
Benzylpenicilloyl PolylysineThe serum concentration of Annamycin can be decreased when it is combined with Benzylpenicilloyl Polylysine.Approved
BevacizumabBevacizumab may increase the cardiotoxic activities of Annamycin.Approved, Investigational
BevoniumBevonium may decrease the excretion rate of Annamycin which could result in a higher serum level.Experimental
Botulinum Toxin Type AAnnamycin may increase the neuromuscular blocking activities of Botulinum Toxin Type A.Approved, Investigational
Botulinum Toxin Type BAnnamycin may increase the neuromuscular blocking activities of Botulinum Toxin Type B.Approved
BromfenacBromfenac may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved
BucillamineBucillamine may decrease the excretion rate of Annamycin which could result in a higher serum level.Investigational
BufexamacBufexamac may decrease the excretion rate of Annamycin which could result in a higher serum level.Experimental
BumadizoneBumadizone may decrease the excretion rate of Annamycin which could result in a higher serum level.Experimental
BumetanideThe risk or severity of adverse effects can be increased when Bumetanide is combined with Annamycin.Approved
CapreomycinCapreomycin may increase the neuromuscular blocking activities of Annamycin.Approved
Carbaspirin calciumCarbaspirin calcium may decrease the excretion rate of Annamycin which could result in a higher serum level.Experimental, Investigational
CarbenicillinThe serum concentration of Annamycin can be decreased when it is combined with Carbenicillin.Approved, Investigational
Carbenicillin indanylThe serum concentration of Annamycin can be decreased when it is combined with Carbenicillin indanyl.Approved, Investigational
CarboplatinAnnamycin may increase the ototoxic activities of Carboplatin.Approved
CarfecillinThe serum concentration of Annamycin can be decreased when it is combined with Carfecillin.Experimental
CarprofenCarprofen may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved, Vet Approved, Withdrawn
CastanospermineCastanospermine may decrease the excretion rate of Annamycin which could result in a higher serum level.Experimental
CelecoxibCelecoxib may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved, Investigational
ChloroquineChloroquine may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved, Vet Approved
Choline magnesium trisalicylateCholine magnesium trisalicylate may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved
CisatracuriumAnnamycin may increase the respiratory depressant activities of Cisatracurium.Approved, Experimental
Cisatracurium besylateAnnamycin may increase the respiratory depressant activities of Cisatracurium besylate.Approved
CisplatinCisplatin may increase the nephrotoxic activities of Annamycin.Approved
Clodronic AcidAnnamycin may increase the hypocalcemic activities of Clodronic Acid.Approved, Investigational, Vet Approved
ClonixinClonixin may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved
CloxacillinThe serum concentration of Annamycin can be decreased when it is combined with Cloxacillin.Approved, Vet Approved
ColistimethateAnnamycin may increase the nephrotoxic activities of Colistimethate.Approved, Vet Approved
CurcuminCurcumin may decrease the excretion rate of Annamycin which could result in a higher serum level.Investigational
CyclacillinThe serum concentration of Annamycin can be decreased when it is combined with Cyclacillin.Approved
CyclophosphamideCyclophosphamide may increase the cardiotoxic activities of Annamycin.Approved, Investigational
CyclosporineAnnamycin may increase the nephrotoxic activities of Cyclosporine.Approved, Investigational, Vet Approved
CymarinCymarin may decrease the cardiotoxic activities of Annamycin.Experimental
DecamethoniumAnnamycin may increase the respiratory depressant activities of Decamethonium.Approved
DeslanosideDeslanoside may decrease the cardiotoxic activities of Annamycin.Approved
DiclofenacDiclofenac may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved, Vet Approved
DicloxacillinThe serum concentration of Annamycin can be decreased when it is combined with Dicloxacillin.Approved, Vet Approved
DifenpiramideDifenpiramide may decrease the excretion rate of Annamycin which could result in a higher serum level.Experimental
DiflunisalDiflunisal may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved
DigitoxinDigitoxin may decrease the cardiotoxic activities of Annamycin.Approved, Investigational
DigoxinDigoxin may decrease the cardiotoxic activities of Annamycin.Approved
Digoxin Immune Fab (Ovine)Digoxin Immune Fab (Ovine) may decrease the cardiotoxic activities of Annamycin.Approved
Domoic AcidAnnamycin may increase the respiratory depressant activities of Domoic Acid.Experimental
Doxacurium chlorideAnnamycin may increase the respiratory depressant activities of Doxacurium chloride.Approved
DroxicamDroxicam may decrease the excretion rate of Annamycin which could result in a higher serum level.Withdrawn
DuvelisibDuvelisib may decrease the excretion rate of Annamycin which could result in a higher serum level.Investigational
E-6201E-6201 may decrease the excretion rate of Annamycin which could result in a higher serum level.Investigational
EpicillinThe serum concentration of Annamycin can be decreased when it is combined with Epicillin.Experimental
EpirizoleEpirizole may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved
Etacrynic acidThe risk or severity of adverse effects can be increased when Etacrynic acid is combined with Annamycin.Approved
EtanerceptEtanercept may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved, Investigational
EthenzamideEthenzamide may decrease the excretion rate of Annamycin which could result in a higher serum level.Experimental
Etidronic acidAnnamycin may increase the hypocalcemic activities of Etidronic acid.Approved
EtodolacEtodolac may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved, Investigational, Vet Approved
EtofenamateEtofenamate may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved, Investigational
EtoricoxibEtoricoxib may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved, Investigational
Evening primrose oilEvening primrose oil may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved, Investigational
ExisulindExisulind may decrease the excretion rate of Annamycin which could result in a higher serum level.Investigational
FelbinacFelbinac may decrease the excretion rate of Annamycin which could result in a higher serum level.Experimental
FenbufenFenbufen may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved
FenoprofenFenoprofen may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved
FentiazacFentiazac may decrease the excretion rate of Annamycin which could result in a higher serum level.Experimental
FeprazoneFeprazone may decrease the excretion rate of Annamycin which could result in a higher serum level.Experimental
Ferulic acidFerulic acid may decrease the excretion rate of Annamycin which could result in a higher serum level.Experimental
FloctafenineFloctafenine may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved, Withdrawn
FlucloxacillinThe serum concentration of Annamycin can be decreased when it is combined with Flucloxacillin.Approved, Investigational
FlunixinFlunixin may decrease the excretion rate of Annamycin which could result in a higher serum level.Vet Approved
FlunoxaprofenFlunoxaprofen may decrease the excretion rate of Annamycin which could result in a higher serum level.Experimental
FlurbiprofenFlurbiprofen may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved, Investigational
FoscarnetFoscarnet may increase the nephrotoxic activities of Annamycin.Approved
FurosemideThe risk or severity of adverse effects can be increased when Furosemide is combined with Annamycin.Approved, Vet Approved
GallamineAnnamycin may increase the respiratory depressant activities of Gallamine.Experimental
Gallamine TriethiodideAnnamycin may increase the respiratory depressant activities of Gallamine Triethiodide.Approved
GitoformateGitoformate may decrease the cardiotoxic activities of Annamycin.Experimental
GuacetisalGuacetisal may decrease the excretion rate of Annamycin which could result in a higher serum level.Experimental
HigenamineHigenamine may decrease the excretion rate of Annamycin which could result in a higher serum level.Investigational
IbandronateAnnamycin may increase the hypocalcemic activities of Ibandronate.Approved, Investigational
IbuprofenIbuprofen may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved
IbuproxamIbuproxam may decrease the excretion rate of Annamycin which could result in a higher serum level.Withdrawn
IcatibantIcatibant may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved
Imidazole salicylateImidazole salicylate may decrease the excretion rate of Annamycin which could result in a higher serum level.Experimental
IndobufenIndobufen may decrease the excretion rate of Annamycin which could result in a higher serum level.Investigational
IndomethacinIndomethacin may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved, Investigational
IndoprofenIndoprofen may decrease the excretion rate of Annamycin which could result in a higher serum level.Withdrawn
IsoxicamIsoxicam may decrease the excretion rate of Annamycin which could result in a higher serum level.Withdrawn
KebuzoneKebuzone may decrease the excretion rate of Annamycin which could result in a higher serum level.Experimental
KetoprofenKetoprofen may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved, Vet Approved
KetorolacKetorolac may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved
Lanatoside CLanatoside C may decrease the cardiotoxic activities of Annamycin.Experimental
LeflunomideLeflunomide may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved, Investigational
LisofyllineLisofylline may decrease the excretion rate of Annamycin which could result in a higher serum level.Investigational
LonazolacLonazolac may decrease the excretion rate of Annamycin which could result in a higher serum level.Experimental
LornoxicamLornoxicam may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved, Investigational
LoxoprofenLoxoprofen may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved, Investigational
LumiracoxibLumiracoxib may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved, Investigational
Magnesium salicylateMagnesium salicylate may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved
MannitolMannitol may increase the nephrotoxic activities of Annamycin.Approved, Investigational
MasoprocolMasoprocol may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved, Investigational
MecamylamineAnnamycin may increase the neuromuscular blocking activities of Mecamylamine.Approved
Meclofenamic acidMeclofenamic acid may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved, Vet Approved
Mefenamic acidMefenamic acid may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved
MeloxicamMeloxicam may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved, Vet Approved
MesalazineMesalazine may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved
MetamizoleMetamizole may decrease the excretion rate of Annamycin which could result in a higher serum level.Investigational, Withdrawn
MetampicillinThe serum concentration of Annamycin can be decreased when it is combined with Metampicillin.Experimental
MeticillinThe serum concentration of Annamycin can be decreased when it is combined with Meticillin.Approved, Investigational
MetildigoxinMetildigoxin may decrease the cardiotoxic activities of Annamycin.Experimental
MetocurineAnnamycin may increase the respiratory depressant activities of Metocurine.Approved
Metocurine IodideAnnamycin may increase the respiratory depressant activities of Metocurine Iodide.Withdrawn
MezlocillinThe serum concentration of Annamycin can be decreased when it is combined with Mezlocillin.Approved, Investigational
MivacuriumAnnamycin may increase the respiratory depressant activities of Mivacurium.Approved
MizoribineMizoribine may decrease the excretion rate of Annamycin which could result in a higher serum level.Investigational
MofebutazoneMofebutazone may decrease the excretion rate of Annamycin which could result in a higher serum level.Experimental
Mycophenolate mofetilMycophenolate mofetil may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved, Investigational
Mycophenolic acidMycophenolic acid may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved
NabumetoneNabumetone may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved
NafamostatNafamostat may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved, Investigational
NafcillinThe serum concentration of Annamycin can be decreased when it is combined with Nafcillin.Approved
NaftifineNaftifine may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved
NaproxenNaproxen may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved, Vet Approved
NeosaxitoxinAnnamycin may increase the respiratory depressant activities of Neosaxitoxin.Investigational
NepafenacNepafenac may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved
NifenazoneNifenazone may decrease the excretion rate of Annamycin which could result in a higher serum level.Experimental
Niflumic AcidNiflumic Acid may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved
NimesulideNimesulide may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved, Investigational, Withdrawn
NitroaspirinNitroaspirin may decrease the excretion rate of Annamycin which could result in a higher serum level.Investigational
OleandrinOleandrin may decrease the cardiotoxic activities of Annamycin.Experimental, Investigational
OlopatadineOlopatadine may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved
OlsalazineOlsalazine may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved
OrgoteinOrgotein may decrease the excretion rate of Annamycin which could result in a higher serum level.Vet Approved
OuabainOuabain may decrease the cardiotoxic activities of Annamycin.Approved
OxacillinThe serum concentration of Annamycin can be decreased when it is combined with Oxacillin.Approved
OxaprozinOxaprozin may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved
OxyphenbutazoneOxyphenbutazone may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved, Withdrawn
PamidronateAnnamycin may increase the hypocalcemic activities of Pamidronate.Approved
PancuroniumAnnamycin may increase the respiratory depressant activities of Pancuronium.Approved
ParecoxibParecoxib may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved
ParthenolideParthenolide may decrease the excretion rate of Annamycin which could result in a higher serum level.Investigational
PenamecillinThe serum concentration of Annamycin can be decreased when it is combined with Penamecillin.Experimental
PenimepicyclineThe serum concentration of Annamycin can be decreased when it is combined with Penimepicycline.Experimental
PeruvosidePeruvoside may decrease the cardiotoxic activities of Annamycin.Experimental
PhenoxymethylpenicillinThe serum concentration of Annamycin can be decreased when it is combined with Phenoxymethylpenicillin.Approved, Vet Approved
PhenylbutazonePhenylbutazone may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved, Vet Approved
PimecrolimusPimecrolimus may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved, Investigational
PipecuroniumAnnamycin may increase the respiratory depressant activities of Pipecuronium.Approved
PiperacillinThe serum concentration of Annamycin can be decreased when it is combined with Piperacillin.Approved
PiretanideThe risk or severity of adverse effects can be increased when Piretanide is combined with Annamycin.Experimental
PirfenidonePirfenidone may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved, Investigational
PiroxicamPiroxicam may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved, Investigational
PirprofenPirprofen may decrease the excretion rate of Annamycin which could result in a higher serum level.Experimental
PivampicillinThe serum concentration of Annamycin can be decreased when it is combined with Pivampicillin.Approved
PivmecillinamThe serum concentration of Annamycin can be decreased when it is combined with Pivmecillinam.Approved
PranoprofenPranoprofen may decrease the excretion rate of Annamycin which could result in a higher serum level.Experimental, Investigational
Procaine benzylpenicillinThe serum concentration of Annamycin can be decreased when it is combined with Procaine benzylpenicillin.Approved, Vet Approved
ProglumetacinProglumetacin may decrease the excretion rate of Annamycin which could result in a higher serum level.Experimental
PropacetamolPropacetamol may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved, Investigational
PropicillinThe serum concentration of Annamycin can be decreased when it is combined with Propicillin.Experimental
PropyphenazonePropyphenazone may decrease the excretion rate of Annamycin which could result in a higher serum level.Experimental
ProquazoneProquazone may decrease the excretion rate of Annamycin which could result in a higher serum level.Experimental
ProscillaridinProscillaridin may decrease the cardiotoxic activities of Annamycin.Experimental
PTC299PTC299 may decrease the excretion rate of Annamycin which could result in a higher serum level.Investigational
PyrantelAnnamycin may increase the respiratory depressant activities of Pyrantel.Approved, Vet Approved
RapacuroniumAnnamycin may increase the respiratory depressant activities of Rapacuronium.Withdrawn
ResveratrolResveratrol may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved, Experimental, Investigational
RisedronateAnnamycin may increase the hypocalcemic activities of Risedronate.Approved, Investigational
RocuroniumAnnamycin may increase the respiratory depressant activities of Rocuronium.Approved
RofecoxibRofecoxib may decrease the excretion rate of Annamycin which could result in a higher serum level.Investigational, Withdrawn
SalicylamideSalicylamide may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved
Salicylic acidSalicylic acid may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved, Vet Approved
SalsalateSalsalate may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved
SemapimodSemapimod may decrease the excretion rate of Annamycin which could result in a higher serum level.Investigational
SeratrodastSeratrodast may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved
SerrapeptaseSerrapeptase may decrease the excretion rate of Annamycin which could result in a higher serum level.Investigational
SRT501SRT501 may decrease the excretion rate of Annamycin which could result in a higher serum level.Investigational
SuccinylcholineAnnamycin may increase the respiratory depressant activities of Succinylcholine.Approved
SulbactamThe serum concentration of Annamycin can be decreased when it is combined with Sulbactam.Approved
SulbenicillinThe serum concentration of Annamycin can be decreased when it is combined with Sulbenicillin.Experimental
SulfasalazineSulfasalazine may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved
SulindacSulindac may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved
SultamicillinThe serum concentration of Annamycin can be decreased when it is combined with Sultamicillin.Investigational
SuprofenSuprofen may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved, Withdrawn
SuxibuzoneSuxibuzone may decrease the excretion rate of Annamycin which could result in a higher serum level.Experimental
TalampicillinThe serum concentration of Annamycin can be decreased when it is combined with Talampicillin.Experimental
TarenflurbilTarenflurbil may decrease the excretion rate of Annamycin which could result in a higher serum level.Investigational
TazobactamThe serum concentration of Annamycin can be decreased when it is combined with Tazobactam.Approved
Technetium Tc-99m etidronateAnnamycin may increase the hypocalcemic activities of Technetium Tc-99m etidronate.Approved
Technetium Tc-99m medronateAnnamycin may increase the hypocalcemic activities of Technetium Tc-99m medronate.Approved
TenidapTenidap may decrease the excretion rate of Annamycin which could result in a higher serum level.Experimental
Tenofovir disoproxilThe serum concentration of Annamycin can be increased when it is combined with Tenofovir disoproxil.Approved, Investigational
TenoxicamTenoxicam may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved
TepoxalinTepoxalin may decrease the excretion rate of Annamycin which could result in a higher serum level.Vet Approved
TeriflunomideTeriflunomide may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved
Tiaprofenic acidTiaprofenic acid may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved
TicarcillinThe serum concentration of Annamycin can be decreased when it is combined with Ticarcillin.Approved, Investigational, Vet Approved
Tiludronic acidAnnamycin may increase the hypocalcemic activities of Tiludronic acid.Approved, Investigational, Vet Approved
TinoridineTinoridine may decrease the excretion rate of Annamycin which could result in a higher serum level.Investigational
Tolfenamic AcidTolfenamic Acid may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved
TolmetinTolmetin may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved
TorasemideThe risk or severity of adverse effects can be increased when Torasemide is combined with Annamycin.Approved
TranilastTranilast may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved, Investigational
TrastuzumabTrastuzumab may increase the cardiotoxic activities of Annamycin.Approved, Investigational
TribenosideTribenoside may decrease the excretion rate of Annamycin which could result in a higher serum level.Experimental
TriptolideTriptolide may decrease the excretion rate of Annamycin which could result in a higher serum level.Investigational
TubocurarineAnnamycin may increase the respiratory depressant activities of Tubocurarine.Approved
ValdecoxibValdecoxib may decrease the excretion rate of Annamycin which could result in a higher serum level.Investigational, Withdrawn
VancomycinVancomycin may increase the nephrotoxic activities of Annamycin.Approved
VecuroniumAnnamycin may increase the respiratory depressant activities of Vecuronium.Approved
ZaltoprofenZaltoprofen may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved, Investigational
ZileutonZileuton may decrease the excretion rate of Annamycin which could result in a higher serum level.Approved, Investigational, Withdrawn
Zoledronic acidAnnamycin may increase the hypocalcemic activities of Zoledronic acid.Approved
ZomepiracZomepirac may decrease the excretion rate of Annamycin which could result in a higher serum level.Withdrawn
Food Interactions
Not Available

References

General References
  1. Trevino AV, Woynarowska BA, Herman TS, Priebe W, Woynarowski JM: Enhanced topoisomerase II targeting by annamycin and related 4-demethoxy anthracycline analogues. Mol Cancer Ther. 2004 Nov;3(11):1403-10. [PubMed:15542779]
External Links
ChemSpider
103088
Wikipedia
Annamycin

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.527 mg/mLALOGPS
logP2.16ALOGPS
logP2.65ChemAxon
logS-3.1ALOGPS
pKa (Strongest Acidic)8.05ChemAxon
pKa (Strongest Basic)-3.3ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count11ChemAxon
Hydrogen Donor Count6ChemAxon
Polar Surface Area191.05 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity139.24 m3·mol-1ChemAxon
Polarizability55.55 Å3ChemAxon
Number of Rings5ChemAxon
Bioavailability0ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Classification
Not classified

Targets

Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Ubiquitin binding
Specific Function
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segr...
Gene Name
TOP2A
Uniprot ID
P11388
Uniprot Name
DNA topoisomerase 2-alpha
Molecular Weight
174383.88 Da
2. DNA
Kind
Nucleotide
Organism
Human
Pharmacological action
Unknown
General Function:
Used for biological information storage.
Specific Function:
DNA contains the instructions needed for an organism to develop, survive and reproduce.
Molecular Weight:
2.15 x 1012 Da

Drug created on March 19, 2008 10:33 / Updated on January 05, 2018 16:03