Morphinans

Compounds based on a partially saturated iminoethanophenanthrene, which can be described as ethylimino-bridged benzo-decahydronaphthalenes. They include some of the OPIOIDS found in PAPAVER that are used as ANALGESICS.
DrugDrug NameDrug Indication
DB00318CodeineCodeine sulfate is a form of this drug that is commonly used. It is available in tablet form [FDA label] and indicated for the relief of mild to moderately severe pain, where the use of an opioid analgesic is appropriate [FDA label]. The solution form is used by itself or combined in a syrup with other drugs and is used as a cough suppressant in adults aged 18 and above [L5521], [L5524].
DB00327HydromorphoneHydromorphone is indicated for the management of moderate to severe acute pain and severe chronic pain. Due to its addictive potential and overdose risk, hydromorphone is only prescribed when other first-line treatments have failed.[A176468] The WHO has proposed a three-step ladder for the management of pain in which it is suggested to start with a non-opioid medication followed by addition of weak opioids to the non-opioid treatment for moderate pain and finishing in the use of strong opioids such as hydromorphone along with the existing regimen for cases of severe pain.[A176471] Off-label, hydromorphone can be administered for the suppression of refractory cough.[A176468]
DB00497OxycodoneFor the treatment of diarrhoea, pulmonary oedema and for the relief of moderate to moderately severe pain.
DB00504LevallorphanFor the complete or partial reversal of narcotic depression, including respiratory depression, induced by opioids.
DB00514DextromethorphanFor treatment and relief of dry cough.
DB00611ButorphanolFor the relief of moderate to severe pain.
DB00652PentazocineFor the relief of moderate to severe pain.
DB00704NaltrexoneUsed as an adjunct to a medically supervised behaviour modification program in the maintenance of opiate cessation in individuals who were formerly physically dependent on opiates and who have successfully undergone detoxification. Also used for the management of alcohol dependence in conjunction with a behavioural modification program.
DB00844NalbuphineFor the relief of moderate to severe pain.
DB00854LevorphanolFor the management of moderate to severe pain or as a preoperative medication where an opioid analgesic is appropriate.
DB00921BuprenorphineFor the treatment of moderate to severe pain, peri-operative analgesia, and opioid dependence.
DB00956HydrocodoneFor relief of moderate to moderately severe pain. Also used for the symptomatic relief of nonproductive cough, alone or in combination with other antitussives or expectorants.
DB01183NaloxoneFor the complete or partial reversal of narcotic depression, including respiratory depression, induced by opioids including natural and synthetic narcotics, propoxyphene, methadone and the narcotic-antagonist analgesics: nalbuphine, pentazocine and butorphanol. It is also indicated for the diagnosis of suspected acute opioid overdose. It may also be used as an adjunctive agent to increase blood pressure in the management of septic shock.
DB01192OxymorphoneFor the treatment of moderate-to-severe pain.
DB014415-Methoxy-N,N-diisopropyltryptamineNot Available
DB01450DihydroetorphineNot Available
DB01452DiamorphineDiamorphine, as a prescription medication in the United Kingdom, is indicated for use in the treatment of severe pain associated with surgical procedures, myocardial infarction or pain in the terminally ill and for the relief of dyspnoea in acute pulmonary edema [L4999].
DB01466EthylmorphineEthylmorphine is an analgesic used for pain relief.
DB01497EtorphineNot Available
DB01531DesomorphineNot Available
DB01547DrotebanolNot Available
DB01548DiprenorphineDiprenorphine is used to reverse the effects of the super-potent opioid analgesics such as etorphine and carfentanil that are used for tranquilizing large animals in veterinary medicine. Not used in humans.
DB01551DihydrocodeineDihydrocodeine is used for the treatment of moderate to severe pain, including post-operative and dental pain [2]. It can also be used to treat chronic pain [1], breathlessness and coughing. In heroin addicts, dihydrocodeine has been used as a substitute drug, in doses up to 2500mg/day to treat addiction. [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2014322/]
DB01565DihydromorphineDihydromorphine is an opioid analgesic used for moderate to severe pain relief.
DB06230NalmefeneIndicated for the reduction of alcohol consumption in adult patients with alcohol dependence who have a high drinking risk level (DRL), without physical withdrawal symptoms and who do not require immediate detoxification [L1024]. Indicated for the complete or partial reversal of opioid drug effects, including respiratory depression - induced by either natural or synthetic opioids - or in the management of known or suspected opioid overdose [FDA Label].
DB06800MethylnaltrexoneTreatment of opioids induced constipation in palliative patients that are inadequately responding to laxative therapy.
DB09209PholcodinePholcodine is indicated as a cough suppressant for the temporary relief of non-productive dry cough. It is stated to present a required label indication of "temporary relief of dry cough."[L1200] Cough is the respiratory movement that occurs after an irritation signal is transmitted to the central nervous system and further stimulates the medulla oblongata. This stimulation causes a motor output that is sent through motoneurons to the respiratory muscles. A non-productive cough is a type of cough characterized by the absence of sputum, and it has a large inspiration that will cause continuous coughing.
DB11490NalorphineUsed to reverse opioid overdose.
DB12543SamidorphanNot Available
DB14682DextrorphanNot Available
DB06409Morphine glucuronideInvestigated for use/treatment in pain (acute or chronic).
DrugDrug NameTargetType
DB00318CodeineMu-type opioid receptortarget
DB00318CodeineDelta-type opioid receptortarget
DB00318CodeineKappa-type opioid receptortarget
DB00318CodeineCytochrome P450 2D6enzyme
DB00318CodeineCytochrome P450 3A4enzyme
DB00318CodeineSolute carrier family 22 member 1transporter
DB00318CodeineUDP-glucuronosyltransferase 2B7enzyme
DB00318CodeineUDP-glucuronosyltransferase 2B4enzyme
DB00318CodeineMagnesium stearatecarrier
DB00318CodeineLactose monohydratecarrier
DB00318CodeineStarch, pregelatinizedcarrier
DB00318CodeineSodium starch glycolatecarrier
DB00327HydromorphoneMu-type opioid receptortarget
DB00327HydromorphoneDelta-type opioid receptortarget
DB00327HydromorphoneKappa-type opioid receptortarget
DB00327HydromorphoneCytochrome P450 3A4enzyme
DB00327HydromorphoneCytochrome P450 2C9enzyme
DB00327HydromorphoneUDP-glucuronosyltransferase 1-3enzyme
DB00327HydromorphoneUDP-glucuronosyltransferase 2B7enzyme
DB00327HydromorphoneSerum albumincarrier
DB00497OxycodoneMu-type opioid receptortarget
DB00497OxycodoneKappa-type opioid receptortarget
DB00497OxycodoneDelta-type opioid receptortarget
DB00497OxycodoneCytochrome P450 2D6enzyme
DB00497OxycodoneCytochrome P450 3A4enzyme
DB00497OxycodoneCytochrome P450 3A5enzyme
DB00497OxycodoneKappa-type opioid receptor 2btarget
DB00497Oxycodonealpha1-acid glycoproteintarget
DB00504LevallorphanMu-type opioid receptortarget
DB00514DextromethorphanSigma non-opioid intracellular receptor 1target
DB00514DextromethorphanHCG20471, isoform CRA_ctarget
DB00514DextromethorphanNeuronal acetylcholine receptor subunit alpha-2target
DB00514DextromethorphanSodium-dependent serotonin transportertarget
DB00514DextromethorphanGlutamate receptor ionotropic, NMDA 3Atarget
DB00514DextromethorphanCytochrome P450 2D6enzyme
DB00514DextromethorphanCytochrome P450 3A4enzyme
DB00514DextromethorphanCytochrome P450 3A5enzyme
DB00514DextromethorphanCytochrome P450 3A7enzyme
DB00514DextromethorphanCytochrome P450 2C9enzyme
DB00514DextromethorphanCytochrome P450 2B6enzyme
DB00514DextromethorphanCytochrome P450 2C19enzyme
DB00514DextromethorphanCytochrome P450 2C8enzyme
DB00514DextromethorphanCytochrome P450 2E1enzyme
DB00514DextromethorphanMembrane-associated progesterone receptor component 1target
DB00514DextromethorphanNeuronal acetylcholine receptor subunit alpha-3target
DB00514DextromethorphanNeuronal acetylcholine receptor subunit alpha-4target
DB00514DextromethorphanNeuronal acetylcholine receptor subunit beta-4target
DB00514DextromethorphanNeuronal acetylcholine receptor subunit beta-2target
DB00514DextromethorphanNeuronal acetylcholine receptor subunit alpha-7target
DB00514DextromethorphanMu-type opioid receptortarget
DB00514DextromethorphanDelta-type opioid receptortarget
DB00514DextromethorphanKappa-type opioid receptortarget
DB00514DextromethorphanNADPH oxidasetarget
DB00514DextromethorphanSodium-dependent noradrenaline transportertarget
DB00611ButorphanolKappa-type opioid receptortarget
DB00611ButorphanolMu-type opioid receptortarget
DB00611ButorphanolDelta-type opioid receptortarget
DB00652PentazocineMu-type opioid receptortarget
DB00652PentazocineKappa-type opioid receptortarget
DB00652PentazocineSigma non-opioid intracellular receptor 1target
DB00704NaltrexoneMu-type opioid receptortarget
DB00704NaltrexoneKappa-type opioid receptortarget
DB00704NaltrexoneDelta-type opioid receptortarget
DB00704NaltrexoneHCG20471, isoform CRA_ctarget
DB00704NaltrexoneUDP-glucuronosyltransferase 1-1enzyme
DB00844NalbuphineKappa-type opioid receptortarget
DB00844NalbuphineMu-type opioid receptortarget
DB00844NalbuphineDelta-type opioid receptortarget
DB00854LevorphanolMu-type opioid receptortarget
DB00854LevorphanolDelta-type opioid receptortarget
DB00854LevorphanolKappa-type opioid receptortarget
DB00921BuprenorphineKappa-type opioid receptortarget
DB00921BuprenorphineMu-type opioid receptortarget
DB00921BuprenorphineCytochrome P450 3A4enzyme
DB00921BuprenorphineCytochrome P450 2D6enzyme
DB00921BuprenorphineMultidrug resistance protein 1transporter
DB00921BuprenorphineATP-binding cassette sub-family G member 2transporter
DB00921BuprenorphineCytochrome P450 2C9enzyme
DB00921BuprenorphineCytochrome P450 3A5enzyme
DB00921BuprenorphineCytochrome P450 2C8enzyme
DB00921BuprenorphineCytochrome P450 3A7enzyme
DB00921BuprenorphineUDP-glucuronosyltransferase 1-9enzyme
DB00921BuprenorphineDelta-type opioid receptortarget
DB00921BuprenorphineCytochrome P450 2A6enzyme
DB00921BuprenorphineCytochrome P450 2C18enzyme
DB00921BuprenorphineCytochrome P450 2C19enzyme
DB00921BuprenorphineNociceptin receptortarget
DB00921BuprenorphineUDP-glucuronosyltransferase 1-1enzyme
DB00956HydrocodoneMu-type opioid receptortarget
DB00956HydrocodoneDelta-type opioid receptortarget
DB00956HydrocodoneCytochrome P450 3A4enzyme
DB00956HydrocodoneCytochrome P450 2D6enzyme
DB01183NaloxoneMu-type opioid receptortarget
DB01183NaloxoneEstrogen receptor alphatarget
DB01183NaloxoneCyclic AMP-responsive element-binding protein 1target
DB01183NaloxoneDelta-type opioid receptortarget
DB01183NaloxoneSolute carrier organic anion transporter family member 1A2transporter
DB01183NaloxoneMultidrug resistance protein 1transporter
DB01183NaloxoneKappa-type opioid receptortarget
DB01183NaloxoneCytochrome P450 2C8enzyme
DB01183NaloxoneCytochrome P450 3A4enzyme
DB01183NaloxoneSerum albumincarrier
DB01183NaloxoneToll-like receptor 4target
DB01183NaloxoneLiver carboxylesterase 1target
DB01183NaloxoneUDP-glucuronosyltransferase 1-1enzyme
DB01192OxymorphoneMu-type opioid receptortarget
DB01192OxymorphoneCytochrome P450 2D6enzyme
DB01192OxymorphoneDelta-type opioid receptortarget
DB01192OxymorphoneCytochrome P450 3A4enzyme
DB01452DiamorphineMu-type opioid receptortarget
DB01452DiamorphineKappa-type opioid receptortarget
DB01452DiamorphineDelta-type opioid receptortarget
DB01452DiamorphineLiver carboxylesterase 1target
DB01452DiamorphineThyroxine-binding globulincarrier
DB01466EthylmorphineCytochrome P450 2D6enzyme
DB01466EthylmorphineNADPH--cytochrome P450 reductaseenzyme
DB01466EthylmorphineMu-type opioid receptortarget
DB01466EthylmorphineCytochrome P450 2B6enzyme
DB01466EthylmorphineCytochrome P450 3A4enzyme
DB01497EtorphineE3 ubiquitin-protein ligase TRIM13target
DB01497EtorphinePro-opiomelanocortintarget
DB01497EtorphineMu-type opioid receptortarget
DB01497EtorphineDelta-type opioid receptortarget
DB01497EtorphineKappa-type opioid receptortarget
DB01497EtorphineNociceptin receptortarget
DB01548DiprenorphineE3 ubiquitin-protein ligase TRIM13target
DB01548DiprenorphineDelta-type opioid receptortarget
DB01548DiprenorphineKappa-type opioid receptortarget
DB01548DiprenorphineMu-type opioid receptortarget
DB01551DihydrocodeineCytochrome P450 2D6enzyme
DB01551DihydrocodeineCytochrome P450 3A4enzyme
DB01565DihydromorphineE3 ubiquitin-protein ligase TRIM13target
DB01565DihydromorphinePro-opiomelanocortintarget
DB01565DihydromorphineMu-type opioid receptortarget
DB01565DihydromorphineDelta-type opioid receptortarget
DB01565DihydromorphineKappa-type opioid receptortarget
DB06230NalmefeneMu-type opioid receptortarget
DB06230NalmefeneKappa-type opioid receptortarget
DB06230NalmefeneDelta-type opioid receptortarget
DB06230NalmefeneUDP-glucuronosyltransferase 2B7enzyme
DB06230NalmefeneUDP-glucuronosyltransferase 1-3enzyme
DB06230NalmefeneUDP-glucuronosyltransferase 1-8enzyme
DB06800MethylnaltrexoneMu-type opioid receptortarget
DB06800MethylnaltrexoneKappa-type opioid receptortarget
DB09209PholcodineMu-type opioid receptortarget
DB09209PholcodineKappa-type opioid receptortarget
DB09209PholcodineDelta-type opioid receptortarget
DB06409Morphine glucuronideMu-type opioid receptortarget
DB06409Morphine glucuronideDelta-type opioid receptortarget
DB06409Morphine glucuronideKappa-type opioid receptortarget