Identification

Name
Etorphine
Accession Number
DB01497
Type
Small Molecule
Groups
Illicit, Vet Approved
Description

A narcotic analgesic morphinan used as a sedative in veterinary practice. In Hong Kong, Etorphine is regulated under Schedule 1 of Hong Kong's Chapter 134 Dangerous Drugs Ordinance. It can only be used legally by health professionals and for university research purposes. The substance can be given by pharmacists under a prescription. In the US, Etorphine is listed as a Schedule I drug, although Etorphine hydrochloride is classified as Schedule II.

Structure
Thumb
Synonyms
  • Etorphinum
External IDs
DEA No. 9056 / M99
Product Ingredients
IngredientUNIICASInChI Key
Etorphine Hydrochloride8CBE01N74813764-49-3JNHPUZURWFYYHW-DTUSRQQPSA-N
Categories
UNII
42M2Y6NU9O
CAS number
14521-96-1
Weight
Average: 411.5338
Monoisotopic: 411.240958549
Chemical Formula
C25H33NO4
InChI Key
CAHCBJPUTCKATP-HBDRVVKHSA-N
InChI
InChI=1S/C25H33NO4/c1-5-8-22(2,28)17-14-23-9-10-25(17,29-4)21-24(23)11-12-26(3)18(23)13-15-6-7-16(27)20(30-21)19(15)24/h6-7,9-10,17-18,21,27-28H,5,8,11-14H2,1-4H3/t17?,18-,21?,22?,23-,24+,25?/m1/s1
IUPAC Name
(1R,2R,6S)-19-(2-hydroxypentan-2-yl)-15-methoxy-3-methyl-13-oxa-3-azahexacyclo[13.2.2.1²,⁸.0¹,⁶.0⁶,¹⁴.0⁷,¹²]icosa-7,9,11,16-tetraen-11-ol
SMILES
[H][[email protected]]12CC3=C4C(OC5[[email protected]@]4(CCN1C)[[email protected]]21CC(C(C)(O)CCC)C5(OC)C=C1)=C(O)C=C3

Pharmacology

Indication
Not Available
Structured Indications
Not Available
Pharmacodynamics

Etorphine is a synthetic cousin of morphine and 40,000 times more powerful. It can be produced from thebaine. It is most often used to immobilize elephants and other large mammals. Etorphine is only available legally for veterinary use and is strictly governed by law.

Mechanism of action

Etorphine is an agonist at mu, delta, and kappa opioid receptors. It also has a weak affinity for the ORL1 nociceptin/orphanin FQ receptor.

TargetActionsOrganism
AMu-type opioid receptor
agonist
Human
ADelta-type opioid receptor
agonist
Human
AKappa-type opioid receptor
agonist
Human
UNociceptin receptor
agonist
Human
UE3 ubiquitin-protein ligase TRIM13
agonist
Human
UPro-opiomelanocortinNot AvailableHuman
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
2,5-Dimethoxy-4-ethylamphetamine2,5-Dimethoxy-4-ethylamphetamine may increase the analgesic activities of Etorphine.Experimental, Illicit
3,4-Methylenedioxyamphetamine3,4-Methylenedioxyamphetamine may increase the analgesic activities of Etorphine.Experimental, Illicit
4-Bromo-2,5-dimethoxyamphetamine4-Bromo-2,5-dimethoxyamphetamine may increase the analgesic activities of Etorphine.Experimental, Illicit
7-NitroindazoleThe risk or severity of adverse effects can be increased when Etorphine is combined with 7-Nitroindazole.Experimental
7,8-Dichloro-1,2,3,4-tetrahydroisoquinolineThe risk or severity of adverse effects can be increased when Etorphine is combined with 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline.Experimental
AcepromazineThe risk or severity of adverse effects can be increased when Etorphine is combined with Acepromazine.Approved, Vet Approved
AceprometazineThe risk or severity of adverse effects can be increased when Etorphine is combined with Aceprometazine.Approved
AcetazolamideThe risk or severity of adverse effects can be increased when Etorphine is combined with Acetazolamide.Approved, Vet Approved
AclidiniumThe risk or severity of adverse effects can be increased when Aclidinium is combined with Etorphine.Approved
AdipiplonThe risk or severity of adverse effects can be increased when Etorphine is combined with Adipiplon.Investigational
AgomelatineThe risk or severity of adverse effects can be increased when Etorphine is combined with Agomelatine.Approved, Investigational
AlaproclateEtorphine may increase the serotonergic activities of Alaproclate.Experimental
AlcuroniumThe risk or severity of adverse effects can be increased when Alcuronium is combined with Etorphine.Experimental
AlfaxaloneThe risk or severity of adverse effects can be increased when Etorphine is combined with Alfaxalone.Vet Approved
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Etorphine.Approved, Illicit
AlimemazineAlimemazine may increase the hypotensive activities of Etorphine.Approved, Vet Approved
AllopregnanoloneThe risk or severity of adverse effects can be increased when Etorphine is combined with Allopregnanolone.Investigational
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Etorphine is combined with Alphacetylmethadol.Experimental, Illicit
AlphaprodineThe risk or severity of adverse effects can be increased when Etorphine is combined with Alphaprodine.Illicit
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Etorphine.Approved, Illicit, Investigational
AlvimopanThe risk or severity of adverse effects can be increased when Etorphine is combined with Alvimopan.Approved
AmilorideThe risk or severity of adverse effects can be increased when Etorphine is combined with Amiloride.Approved
AmisulprideThe risk or severity of adverse effects can be increased when Etorphine is combined with Amisulpride.Approved, Investigational
AmitriptylineThe risk or severity of adverse effects can be increased when Etorphine is combined with Amitriptyline.Approved
Ammonium chlorideAmmonium chloride may increase the excretion rate of Etorphine which could result in a lower serum level and potentially a reduction in efficacy.Approved, Vet Approved
AmobarbitalThe risk or severity of adverse effects can be increased when Amobarbital is combined with Etorphine.Approved, Illicit
AmoxapineThe risk or severity of adverse effects can be increased when Etorphine is combined with Amoxapine.Approved
AmperozideThe risk or severity of adverse effects can be increased when Etorphine is combined with Amperozide.Experimental
AmphetamineAmphetamine may increase the analgesic activities of Etorphine.Approved, Illicit
Anisotropine MethylbromideThe risk or severity of adverse effects can be increased when Anisotropine Methylbromide is combined with Etorphine.Approved
AripiprazoleThe risk or severity of adverse effects can be increased when Aripiprazole is combined with Etorphine.Approved, Investigational
ArticaineThe risk or severity of adverse effects can be increased when Etorphine is combined with Articaine.Approved
AsenapineThe risk or severity of adverse effects can be increased when Asenapine is combined with Etorphine.Approved
AtracuriumThe risk or severity of adverse effects can be increased when Atracurium is combined with Etorphine.Experimental, Investigational
Atracurium besylateThe risk or severity of adverse effects can be increased when Atracurium besylate is combined with Etorphine.Approved
AtropineThe risk or severity of adverse effects can be increased when Atropine is combined with Etorphine.Approved, Vet Approved
AzaperoneThe risk or severity of adverse effects can be increased when Etorphine is combined with Azaperone.Investigational, Vet Approved
AzelastineEtorphine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.Approved
AzosemideThe risk or severity of adverse effects can be increased when Etorphine is combined with Azosemide.Investigational
BaclofenThe risk or severity of adverse effects can be increased when Etorphine is combined with Baclofen.Approved
BarbitalThe risk or severity of adverse effects can be increased when Barbital is combined with Etorphine.Illicit
BenactyzineThe risk or severity of adverse effects can be increased when Benactyzine is combined with Etorphine.Withdrawn
BendroflumethiazideThe risk or severity of adverse effects can be increased when Etorphine is combined with Bendroflumethiazide.Approved
BenmoxinThe risk or severity of adverse effects can be increased when Etorphine is combined with Benmoxin.Withdrawn
BenperidolThe risk or severity of adverse effects can be increased when Etorphine is combined with Benperidol.Investigational
BenzatropineThe risk or severity of adverse effects can be increased when Benzatropine is combined with Etorphine.Approved
BenzocaineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Etorphine.Approved
BenzphetamineBenzphetamine may increase the analgesic activities of Etorphine.Approved, Illicit
Benzyl alcoholThe risk or severity of adverse effects can be increased when Etorphine is combined with Benzyl alcohol.Approved
BiperidenThe risk or severity of adverse effects can be increased when Biperiden is combined with Etorphine.Approved, Investigational
BL-1020BL-1020 may increase the hypotensive activities of Etorphine.Investigational
BornaprineThe risk or severity of adverse effects can be increased when Bornaprine is combined with Etorphine.Experimental
BrexpiprazoleThe risk or severity of adverse effects can be increased when Etorphine is combined with Brexpiprazole.Approved
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Etorphine.Approved
BrofaromineThe risk or severity of adverse effects can be increased when Etorphine is combined with Brofaromine.Experimental
BromazepamThe risk or severity of adverse effects can be increased when Bromazepam is combined with Etorphine.Approved, Illicit
BromisovalThe risk or severity of adverse effects can be increased when Etorphine is combined with Bromisoval.Experimental
BromperidolThe risk or severity of adverse effects can be increased when Etorphine is combined with Bromperidol.Investigational
BrompheniramineThe risk or severity of adverse effects can be increased when Etorphine is combined with Brompheniramine.Approved
BrotizolamThe risk or severity of adverse effects can be increased when Etorphine is combined with Brotizolam.Approved, Investigational, Withdrawn
BumetanideThe risk or severity of adverse effects can be increased when Etorphine is combined with Bumetanide.Approved
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Etorphine.Approved, Investigational
BuprenorphineEtorphine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Etorphine.Approved, Investigational
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Etorphine.Approved, Illicit
ButacaineThe risk or severity of adverse effects can be increased when Etorphine is combined with Butacaine.Vet Approved
ButalbitalThe risk or severity of adverse effects can be increased when Etorphine is combined with Butalbital.Approved, Illicit
ButambenThe risk or severity of adverse effects can be increased when Etorphine is combined with Butamben.Approved
ButethalThe risk or severity of adverse effects can be increased when Butethal is combined with Etorphine.Approved, Illicit
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Etorphine.Approved, Illicit, Vet Approved
ButylscopolamineThe risk or severity of adverse effects can be increased when Scopolamine butylbromide is combined with Etorphine.Approved, Vet Approved
CanertinibThe risk or severity of adverse effects can be increased when Etorphine is combined with Canertinib.Investigational
Canrenoic acidThe risk or severity of adverse effects can be increased when Etorphine is combined with Canrenoic acid.Approved, Withdrawn
CanrenoneThe risk or severity of adverse effects can be increased when Etorphine is combined with Canrenone.Investigational
CarbamazepineThe risk or severity of adverse effects can be increased when Carbamazepine is combined with Etorphine.Approved, Investigational
CarbinoxamineThe risk or severity of adverse effects can be increased when Etorphine is combined with Carbinoxamine.Approved
CarfentanilThe risk or severity of adverse effects can be increased when Etorphine is combined with Carfentanil.Illicit, Investigational, Vet Approved
CarisoprodolThe risk or severity of adverse effects can be increased when Etorphine is combined with Carisoprodol.Approved
CaroxazoneThe risk or severity of adverse effects can be increased when Etorphine is combined with Caroxazone.Withdrawn
CetirizineThe risk or severity of adverse effects can be increased when Etorphine is combined with Cetirizine.Approved
Chloral hydrateThe risk or severity of adverse effects can be increased when Etorphine is combined with Chloral hydrate.Approved, Illicit, Vet Approved
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Etorphine.Approved, Illicit
ChlormezanoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Etorphine.Approved, Investigational, Withdrawn
ChloroprocaineThe risk or severity of adverse effects can be increased when Chloroprocaine is combined with Etorphine.Approved
ChlorothiazideThe risk or severity of adverse effects can be increased when Etorphine is combined with Chlorothiazide.Approved, Vet Approved
ChlorphenamineThe risk or severity of adverse effects can be increased when Etorphine is combined with Chlorphenamine.Approved
ChlorphenoxamineThe risk or severity of adverse effects can be increased when Chlorphenoxamine is combined with Etorphine.Withdrawn
ChlorphentermineChlorphentermine may increase the analgesic activities of Etorphine.Illicit, Withdrawn
ChlorproethazineChlorproethazine may increase the hypotensive activities of Etorphine.Experimental
ChlorpromazineThe risk or severity of adverse effects can be increased when Chlorpromazine is combined with Etorphine.Approved, Vet Approved
ChlorprothixeneThe risk or severity of adverse effects can be increased when Chlorprothixene is combined with Etorphine.Approved, Investigational, Withdrawn
ChlorthalidoneThe risk or severity of adverse effects can be increased when Etorphine is combined with Chlorthalidone.Approved
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Etorphine is combined with Chlorzoxazone.Approved
CicletanineThe risk or severity of adverse effects can be increased when Etorphine is combined with Cicletanine.Investigational
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Etorphine.Approved, Vet Approved
CitalopramEtorphine may increase the serotonergic activities of Citalopram.Approved
ClemastineThe risk or severity of adverse effects can be increased when Etorphine is combined with Clemastine.Approved
ClidiniumThe risk or severity of adverse effects can be increased when Etorphine is combined with Clidinium.Approved
ClobazamThe risk or severity of adverse effects can be increased when Etorphine is combined with Clobazam.Approved, Illicit
ClofenamideThe risk or severity of adverse effects can be increased when Etorphine is combined with Clofenamide.Experimental
clomethiazoleThe risk or severity of adverse effects can be increased when Etorphine is combined with clomethiazole.Investigational
ClomipramineThe risk or severity of adverse effects can be increased when Etorphine is combined with Clomipramine.Approved, Vet Approved
ClonazepamThe risk or severity of adverse effects can be increased when Etorphine is combined with Clonazepam.Approved, Illicit
ClonidineThe risk or severity of adverse effects can be increased when Etorphine is combined with Clonidine.Approved
ClopamideThe risk or severity of adverse effects can be increased when Etorphine is combined with Clopamide.Experimental
ClopenthixolThe risk or severity of adverse effects can be increased when Etorphine is combined with Clopenthixol.Experimental
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Etorphine.Approved, Illicit
ClorexoloneThe risk or severity of adverse effects can be increased when Etorphine is combined with Clorexolone.Experimental
ClothiapineThe risk or severity of adverse effects can be increased when Etorphine is combined with Clothiapine.Experimental
ClozapineThe risk or severity of adverse effects can be increased when Clozapine is combined with Etorphine.Approved
CocaineThe risk or severity of adverse effects can be increased when Cocaine is combined with Etorphine.Approved, Illicit
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Etorphine.Approved, Illicit
ConivaptanThe risk or severity of adverse effects can be increased when Etorphine is combined with Conivaptan.Approved, Investigational
CyclizineThe risk or severity of adverse effects can be increased when Etorphine is combined with Cyclizine.Approved
CyclobenzaprineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Etorphine.Approved
CyclopenthiazideThe risk or severity of adverse effects can be increased when Etorphine is combined with Cyclopenthiazide.Experimental
CyclopentolateThe risk or severity of adverse effects can be increased when Cyclopentolate is combined with Etorphine.Approved
CyclothiazideThe risk or severity of adverse effects can be increased when Etorphine is combined with Cyclothiazide.Approved
CyproheptadineThe risk or severity of adverse effects can be increased when Etorphine is combined with Cyproheptadine.Approved
DantroleneThe risk or severity of adverse effects can be increased when Etorphine is combined with Dantrolene.Approved
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Etorphine.Approved
DapoxetineEtorphine may increase the serotonergic activities of Dapoxetine.Investigational
DarifenacinThe risk or severity of adverse effects can be increased when Darifenacin is combined with Etorphine.Approved, Investigational
DeramciclaneThe risk or severity of adverse effects can be increased when Etorphine is combined with Deramciclane.Investigational
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Etorphine.Approved
DesipramineThe risk or severity of adverse effects can be increased when Etorphine is combined with Desipramine.Approved
DesloratadineThe risk or severity of adverse effects can be increased when Etorphine is combined with Desloratadine.Approved, Investigational
DesmopressinThe risk or severity of adverse effects can be increased when Etorphine is combined with Desmopressin.Approved
DesvenlafaxineEtorphine may increase the serotonergic activities of Desvenlafaxine.Approved
DetomidineThe risk or severity of adverse effects can be increased when Etorphine is combined with Detomidine.Vet Approved
DexbrompheniramineThe risk or severity of adverse effects can be increased when Etorphine is combined with Dexbrompheniramine.Approved
DexetimideThe risk or severity of adverse effects can be increased when Dexetimide is combined with Etorphine.Withdrawn
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Etorphine.Approved, Vet Approved
DextroamphetamineDextroamphetamine may increase the analgesic activities of Etorphine.Approved, Illicit
DextromoramideThe risk or severity of adverse effects can be increased when Etorphine is combined with Dextromoramide.Experimental, Illicit
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Etorphine.Approved, Illicit, Investigational, Withdrawn
DezocineThe risk or severity of adverse effects can be increased when Dezocine is combined with Etorphine.Approved, Investigational
DiazepamThe risk or severity of adverse effects can be increased when Diazepam is combined with Etorphine.Approved, Illicit, Vet Approved
DicyclomineThe risk or severity of adverse effects can be increased when Dicyclomine is combined with Etorphine.Approved
Diethyl etherThe risk or severity of adverse effects can be increased when Etorphine is combined with Diethyl ether.Experimental
DiethylpropionDiethylpropion may increase the analgesic activities of Etorphine.Approved, Illicit
DifenoxinThe risk or severity of adverse effects can be increased when Etorphine is combined with Difenoxin.Approved, Illicit
DihydrocodeineThe risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Etorphine.Approved, Illicit
DihydroetorphineThe risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Etorphine.Experimental, Illicit
DihydromorphineThe risk or severity of adverse effects can be increased when Etorphine is combined with Dihydromorphine.Experimental, Illicit
DimenhydrinateThe risk or severity of adverse effects can be increased when Etorphine is combined with Dimenhydrinate.Approved
DiphenhydramineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Etorphine.Approved
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Etorphine.Approved, Illicit
DixyrazineThe risk or severity of adverse effects can be increased when Etorphine is combined with Dixyrazine.Experimental
DoramectinThe risk or severity of adverse effects can be increased when Etorphine is combined with Doramectin.Vet Approved
DoxepinThe risk or severity of adverse effects can be increased when Etorphine is combined with Doxepin.Approved
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Etorphine.Approved, Vet Approved
DPDPEThe risk or severity of adverse effects can be increased when Etorphine is combined with DPDPE.Experimental
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Etorphine.Approved, Illicit
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Etorphine.Approved, Vet Approved
DrospirenoneThe risk or severity of adverse effects can be increased when Etorphine is combined with Drospirenone.Approved
DrotebanolThe risk or severity of adverse effects can be increased when Etorphine is combined with Drotebanol.Experimental, Illicit
DuloxetineEtorphine may increase the serotonergic activities of Duloxetine.Approved
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Etorphine.Approved
EcgonineThe risk or severity of adverse effects can be increased when Etorphine is combined with Ecgonine.Experimental, Illicit
EcopipamThe risk or severity of adverse effects can be increased when Etorphine is combined with Ecopipam.Investigational
EfavirenzThe risk or severity of adverse effects can be increased when Etorphine is combined with Efavirenz.Approved, Investigational
EfonidipineThe risk or severity of adverse effects can be increased when Etorphine is combined with Efonidipine.Approved, Investigational
EltanoloneThe risk or severity of adverse effects can be increased when Etorphine is combined with Eltanolone.Investigational
EluxadolineEtorphine may increase the constipating activities of Eluxadoline.Approved
EmeproniumThe risk or severity of adverse effects can be increased when Emepronium is combined with Etorphine.Experimental
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Etorphine.Approved, Investigational, Vet Approved
EntacaponeThe risk or severity of adverse effects can be increased when Etorphine is combined with Entacapone.Approved, Investigational
EplerenoneThe risk or severity of adverse effects can be increased when Etorphine is combined with Eplerenone.Approved
EscitalopramEtorphine may increase the serotonergic activities of Escitalopram.Approved, Investigational
EstazolamThe risk or severity of adverse effects can be increased when Estazolam is combined with Etorphine.Approved, Illicit
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Etorphine.Approved
Etacrynic acidThe risk or severity of adverse effects can be increased when Etorphine is combined with Etacrynic acid.Approved
EtanautineThe risk or severity of adverse effects can be increased when Etanautine is combined with Etorphine.Experimental
EthanolEtorphine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.Approved
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Etorphine.Approved, Illicit, Withdrawn
EthopropazineThe risk or severity of adverse effects can be increased when Ethopropazine is combined with Etorphine.Approved
EthosuximideThe risk or severity of adverse effects can be increased when Etorphine is combined with Ethosuximide.Approved
EthotoinThe risk or severity of adverse effects can be increased when Etorphine is combined with Ethotoin.Approved
EthoxzolamideThe risk or severity of adverse effects can be increased when Etorphine is combined with Ethoxzolamide.Withdrawn
Ethyl carbamateThe risk or severity of adverse effects can be increased when Etorphine is combined with Ethyl carbamate.Withdrawn
Ethyl chlorideThe risk or severity of adverse effects can be increased when Etorphine is combined with Ethyl chloride.Experimental, Investigational
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Etorphine is combined with Ethyl loflazepate.Approved, Illicit
EthylmorphineThe risk or severity of adverse effects can be increased when Ethylmorphine is combined with Etorphine.Approved, Illicit
EtidocaineThe risk or severity of adverse effects can be increased when Etorphine is combined with Etidocaine.Approved
EtifoxineThe risk or severity of adverse effects can be increased when Etorphine is combined with Etifoxine.Investigational, Withdrawn
EtizolamThe risk or severity of adverse effects can be increased when Etorphine is combined with Etizolam.Approved
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Etorphine.Approved
EtoperidoneEtorphine may increase the serotonergic activities of Etoperidone.Withdrawn
EtybenzatropineThe risk or severity of adverse effects can be increased when Etybenzatropine is combined with Etorphine.Experimental
EzogabineThe risk or severity of adverse effects can be increased when Etorphine is combined with Ezogabine.Approved
FelbamateThe risk or severity of adverse effects can be increased when Etorphine is combined with Felbamate.Approved
FencamfamineThe risk or severity of adverse effects can be increased when Fencamfamine is combined with Etorphine.Approved, Illicit, Withdrawn
FenquizoneThe risk or severity of adverse effects can be increased when Etorphine is combined with Fenquizone.Experimental
FentanylThe risk or severity of adverse effects can be increased when Fentanyl is combined with Etorphine.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe risk or severity of adverse effects can be increased when Fesoterodine is combined with Etorphine.Approved
FexofenadineThe risk or severity of adverse effects can be increased when Etorphine is combined with Fexofenadine.Approved
FlibanserinThe risk or severity of adverse effects can be increased when Etorphine is combined with Flibanserin.Approved
FluanisoneThe risk or severity of adverse effects can be increased when Etorphine is combined with Fluanisone.Experimental
FludiazepamThe risk or severity of adverse effects can be increased when Etorphine is combined with Fludiazepam.Approved, Illicit
FlunarizineThe risk or severity of adverse effects can be increased when Etorphine is combined with Flunarizine.Approved
FlunitrazepamThe risk or severity of adverse effects can be increased when Etorphine is combined with Flunitrazepam.Approved, Illicit
FluoxetineEtorphine may increase the serotonergic activities of Fluoxetine.Approved, Vet Approved
FlupentixolThe risk or severity of adverse effects can be increased when Flupentixol is combined with Etorphine.Approved, Withdrawn
FluphenazineThe risk or severity of adverse effects can be increased when Fluphenazine is combined with Etorphine.Approved
FlurazepamThe risk or severity of adverse effects can be increased when Flurazepam is combined with Etorphine.Approved, Illicit
FluspirileneThe risk or severity of adverse effects can be increased when Etorphine is combined with Fluspirilene.Approved, Investigational
Fluticasone propionateThe risk or severity of adverse effects can be increased when Etorphine is combined with Fluticasone propionate.Approved
FluvoxamineThe risk or severity of adverse effects can be increased when Fluvoxamine is combined with Etorphine.Approved, Investigational
FosphenytoinThe risk or severity of adverse effects can be increased when Etorphine is combined with Fosphenytoin.Approved
FospropofolThe risk or severity of adverse effects can be increased when Etorphine is combined with Fospropofol.Approved, Illicit, Investigational
FurazolidoneThe risk or severity of adverse effects can be increased when Etorphine is combined with Furazolidone.Approved, Investigational, Vet Approved
FurosemideThe risk or severity of adverse effects can be increased when Etorphine is combined with Furosemide.Approved, Vet Approved
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Etorphine.Approved, Investigational
Gabapentin EnacarbilThe risk or severity of adverse effects can be increased when Etorphine is combined with Gabapentin Enacarbil.Approved
GallamineThe risk or severity of adverse effects can be increased when Gallamine is combined with Etorphine.Experimental
Gallamine TriethiodideThe risk or severity of adverse effects can be increased when Gallamine Triethiodide is combined with Etorphine.Approved
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Etorphine.Approved, Illicit, Investigational
GepefrineGepefrine may increase the analgesic activities of Etorphine.Experimental
GepironeThe risk or severity of adverse effects can be increased when Etorphine is combined with Gepirone.Investigational
GlutethimideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Etorphine.Approved, Illicit
GlycopyrroniumThe risk or severity of adverse effects can be increased when Glycopyrronium is combined with Etorphine.Approved, Investigational, Vet Approved
GuanfacineThe risk or severity of adverse effects can be increased when Etorphine is combined with Guanfacine.Approved, Investigational
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with Etorphine.Approved, Illicit, Withdrawn
HaloperidolThe risk or severity of adverse effects can be increased when Haloperidol is combined with Etorphine.Approved
HalothaneThe risk or severity of adverse effects can be increased when Halothane is combined with Etorphine.Approved, Vet Approved
HarmalineThe risk or severity of adverse effects can be increased when Etorphine is combined with Harmaline.Experimental
HeroinThe risk or severity of adverse effects can be increased when Heroin is combined with Etorphine.Approved, Illicit, Investigational
HexamethoniumThe risk or severity of adverse effects can be increased when Hexamethonium is combined with Etorphine.Experimental
HexobarbitalThe risk or severity of adverse effects can be increased when Hexobarbital is combined with Etorphine.Approved
HomatropineThe risk or severity of adverse effects can be increased when Homatropine is combined with Etorphine.Approved
HydracarbazineThe risk or severity of adverse effects can be increased when Etorphine is combined with Hydracarbazine.Experimental
HydrochlorothiazideThe risk or severity of adverse effects can be increased when Etorphine is combined with Hydrochlorothiazide.Approved, Vet Approved
HydrocodoneEtorphine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.Approved, Illicit
HydroflumethiazideThe risk or severity of adverse effects can be increased when Etorphine is combined with Hydroflumethiazide.Approved, Investigational
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Etorphine.Approved, Illicit
HydroxyamphetamineHydroxyamphetamine may increase the analgesic activities of Etorphine.Approved
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Etorphine.Approved
HyoscyamineThe risk or severity of adverse effects can be increased when Hyoscyamine is combined with Etorphine.Approved
IbopamineThe risk or severity of adverse effects can be increased when Etorphine is combined with Ibopamine.Experimental
IloperidoneThe risk or severity of adverse effects can be increased when Etorphine is combined with Iloperidone.Approved
ImipramineThe risk or severity of adverse effects can be increased when Etorphine is combined with Imipramine.Approved
IndalpineEtorphine may increase the serotonergic activities of Indalpine.Investigational, Withdrawn
IndapamideThe risk or severity of adverse effects can be increased when Etorphine is combined with Indapamide.Approved
IndiplonThe risk or severity of adverse effects can be increased when Etorphine is combined with Indiplon.Investigational
Iofetamine I-123Iofetamine I-123 may increase the analgesic activities of Etorphine.Approved
Ipratropium bromideThe risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Etorphine.Approved
IproclozideThe risk or severity of adverse effects can be increased when Etorphine is combined with Iproclozide.Withdrawn
IproniazidThe risk or severity of adverse effects can be increased when Etorphine is combined with Iproniazid.Withdrawn
IsocarboxazidThe risk or severity of adverse effects can be increased when Etorphine is combined with Isocarboxazid.Approved
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Etorphine.Approved, Vet Approved
IsosorbideThe risk or severity of adverse effects can be increased when Etorphine is combined with Isosorbide.Approved, Investigational
KetamineThe risk or severity of adverse effects can be increased when Ketamine is combined with Etorphine.Approved, Vet Approved
KetazolamThe risk or severity of adverse effects can be increased when Etorphine is combined with Ketazolam.Approved
KetobemidoneThe risk or severity of adverse effects can be increased when Etorphine is combined with Ketobemidone.Approved, Investigational
LamotrigineThe risk or severity of adverse effects can be increased when Etorphine is combined with Lamotrigine.Approved, Investigational
LevetiracetamThe risk or severity of adverse effects can be increased when Etorphine is combined with Levetiracetam.Approved, Investigational
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Etorphine.Approved, Investigational
LevocabastineThe risk or severity of adverse effects can be increased when Etorphine is combined with Levocabastine.Approved
LevocetirizineThe risk or severity of adverse effects can be increased when Etorphine is combined with Levocetirizine.Approved
LevodopaThe risk or severity of adverse effects can be increased when Etorphine is combined with Levodopa.Approved
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Etorphine.Approved, Investigational
LevomilnacipranEtorphine may increase the serotonergic activities of Levomilnacipran.Approved
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Etorphine.Approved
LidocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Etorphine.Approved, Vet Approved
LisdexamfetamineLisdexamfetamine may increase the analgesic activities of Etorphine.Approved, Investigational
LithiumThe risk or severity of adverse effects can be increased when Lithium is combined with Etorphine.Approved
LofentanilThe risk or severity of adverse effects can be increased when Etorphine is combined with Lofentanil.Illicit
LoprazolamThe risk or severity of adverse effects can be increased when Etorphine is combined with Loprazolam.Experimental
LoratadineThe risk or severity of adverse effects can be increased when Etorphine is combined with Loratadine.Approved
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Etorphine.Approved
LormetazepamThe risk or severity of adverse effects can be increased when Etorphine is combined with Lormetazepam.Approved
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Etorphine.Approved
LurasidoneThe risk or severity of adverse effects can be increased when Lurasidone is combined with Etorphine.Approved
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Etorphine.Approved, Vet Approved
MannitolThe risk or severity of adverse effects can be increased when Etorphine is combined with Mannitol.Approved, Investigational
MaprotilineThe risk or severity of adverse effects can be increased when Etorphine is combined with Maprotiline.Approved
MazaticolThe risk or severity of adverse effects can be increased when Mazaticol is combined with Etorphine.Experimental
MebanazineThe risk or severity of adverse effects can be increased when Etorphine is combined with Mebanazine.Withdrawn
MebicarThe risk or severity of adverse effects can be increased when Etorphine is combined with Mebicar.Experimental
MebutizideThe risk or severity of adverse effects can be increased when Etorphine is combined with Mebutizide.Experimental
MecamylamineThe risk or severity of adverse effects can be increased when Mecamylamine is combined with Etorphine.Approved
MeclizineThe risk or severity of adverse effects can be increased when Etorphine is combined with Meclizine.Approved
MedazepamThe risk or severity of adverse effects can be increased when Etorphine is combined with Medazepam.Experimental
MedetomidineThe risk or severity of adverse effects can be increased when Etorphine is combined with Medetomidine.Vet Approved
MefrusideThe risk or severity of adverse effects can be increased when Etorphine is combined with Mefruside.Experimental
MelatoninThe risk or severity of adverse effects can be increased when Melatonin is combined with Etorphine.Approved, Nutraceutical, Vet Approved
MelperoneThe risk or severity of adverse effects can be increased when Etorphine is combined with Melperone.Approved, Investigational
MephedroneMephedrone may increase the analgesic activities of Etorphine.Investigational
MephentermineMephentermine may increase the analgesic activities of Etorphine.Approved
MepivacaineThe risk or severity of adverse effects can be increased when Mepivacaine is combined with Etorphine.Approved, Vet Approved
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Etorphine.Approved, Illicit
MeptazinolThe risk or severity of adverse effects can be increased when Etorphine is combined with Meptazinol.Experimental
MersalylThe risk or severity of adverse effects can be increased when Etorphine is combined with Mersalyl.Approved
MesoridazineThe risk or severity of adverse effects can be increased when Mesoridazine is combined with Etorphine.Approved, Investigational
MetaxaloneThe risk or severity of adverse effects can be increased when Etorphine is combined with Metaxalone.Approved
MethadoneThe risk or severity of adverse effects can be increased when Methadone is combined with Etorphine.Approved
Methadyl AcetateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Etorphine.Approved, Illicit
MethamphetamineMethamphetamine may increase the analgesic activities of Etorphine.Approved, Illicit
MethanthelineThe risk or severity of adverse effects can be increased when Methantheline is combined with Etorphine.Approved, Investigational
MethapyrileneThe risk or severity of adverse effects can be increased when Etorphine is combined with Methapyrilene.Withdrawn
MethaqualoneThe risk or severity of adverse effects can be increased when Etorphine is combined with Methaqualone.Illicit, Withdrawn
MethazolamideThe risk or severity of adverse effects can be increased when Etorphine is combined with Methazolamide.Approved
MethocarbamolThe risk or severity of adverse effects can be increased when Etorphine is combined with Methocarbamol.Approved, Vet Approved
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Etorphine.Approved
MethotrimeprazineEtorphine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.Approved
MethoxyfluraneThe risk or severity of adverse effects can be increased when Methoxyflurane is combined with Etorphine.Approved, Investigational, Vet Approved
MethoxyphenamineMethoxyphenamine may increase the analgesic activities of Etorphine.Experimental
MethsuximideThe risk or severity of adverse effects can be increased when Etorphine is combined with Methsuximide.Approved
MethyclothiazideThe risk or severity of adverse effects can be increased when Etorphine is combined with Methyclothiazide.Approved
MethylecgonineThe risk or severity of adverse effects can be increased when Etorphine is combined with Methylecgonine.Experimental
Methylene blueMethylene blue may increase the hypotensive activities of Etorphine.Approved, Investigational
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Etorphine.Approved
Methylscopolamine bromideThe risk or severity of adverse effects can be increased when Methylscopolamine bromide is combined with Etorphine.Approved
MeticraneThe risk or severity of adverse effects can be increased when Etorphine is combined with Meticrane.Experimental
MetixeneThe risk or severity of adverse effects can be increased when Metixene is combined with Etorphine.Approved
MetolazoneThe risk or severity of adverse effects can be increased when Etorphine is combined with Metolazone.Approved
MetyrosineEtorphine may increase the sedative activities of Metyrosine.Approved
MidazolamThe risk or severity of adverse effects can be increased when Midazolam is combined with Etorphine.Approved, Illicit
MidomafetamineMidomafetamine may increase the analgesic activities of Etorphine.Experimental, Illicit, Investigational
MilnacipranEtorphine may increase the serotonergic activities of Milnacipran.Approved
MinaprineThe risk or severity of adverse effects can be increased when Etorphine is combined with Minaprine.Approved
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Etorphine.Approved, Investigational
MirtazapineEtorphine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.Approved
MMDAMMDA may increase the analgesic activities of Etorphine.Experimental, Illicit
MoclobemideThe risk or severity of adverse effects can be increased when Etorphine is combined with Moclobemide.Approved
MolindoneThe risk or severity of adverse effects can be increased when Etorphine is combined with Molindone.Approved
MoricizineMoricizine may increase the hypotensive activities of Etorphine.Approved, Investigational, Withdrawn
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Etorphine.Approved, Investigational
MuzolimineThe risk or severity of adverse effects can be increased when Etorphine is combined with Muzolimine.Experimental
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Etorphine.Approved, Investigational
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Etorphine.Approved
NaltrexoneThe therapeutic efficacy of Etorphine can be decreased when used in combination with Naltrexone.Approved, Investigational, Vet Approved
NefazodoneEtorphine may increase the serotonergic activities of Nefazodone.Approved, Withdrawn
NialamideThe risk or severity of adverse effects can be increased when Etorphine is combined with Nialamide.Withdrawn
NitrazepamThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Etorphine.Approved
Nitrous oxideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Etorphine.Approved, Vet Approved
NorfluraneThe risk or severity of adverse effects can be increased when Etorphine is combined with Norflurane.Investigational
NormethadoneThe risk or severity of adverse effects can be increased when Etorphine is combined with Normethadone.Approved, Illicit
NortriptylineThe risk or severity of adverse effects can be increased when Etorphine is combined with Nortriptyline.Approved
OctamoxinThe risk or severity of adverse effects can be increased when Etorphine is combined with Octamoxin.Withdrawn
OlanzapineThe risk or severity of adverse effects can be increased when Olanzapine is combined with Etorphine.Approved, Investigational
OlopatadineThe risk or severity of adverse effects can be increased when Etorphine is combined with Olopatadine.Approved
OndansetronThe risk or severity of adverse effects can be increased when Ondansetron is combined with Etorphine.Approved
OpiumThe risk or severity of adverse effects can be increased when Etorphine is combined with Opium.Approved, Illicit
OrphenadrineEtorphine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.Approved
OsanetantThe risk or severity of adverse effects can be increased when Etorphine is combined with Osanetant.Investigational
OtiloniumThe risk or severity of adverse effects can be increased when Otilonium is combined with Etorphine.Experimental, Investigational
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with Etorphine.Approved
OxethazaineThe risk or severity of adverse effects can be increased when Etorphine is combined with Oxethazaine.Approved, Investigational
OxitropiumThe risk or severity of adverse effects can be increased when Oxitropium is combined with Etorphine.Investigational
OxprenololThe risk or severity of adverse effects can be increased when Etorphine is combined with Oxprenolol.Approved
OxybuprocaineThe risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Etorphine.Approved
OxybutyninThe risk or severity of adverse effects can be increased when Oxybutynin is combined with Etorphine.Approved, Investigational
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Etorphine.Approved, Illicit, Investigational
OxymorphoneThe risk or severity of adverse effects can be increased when Oxymorphone is combined with Etorphine.Approved, Investigational, Vet Approved
OxyphenoniumThe risk or severity of adverse effects can be increased when Oxyphenonium is combined with Etorphine.Approved
PaliperidoneThe risk or severity of adverse effects can be increased when Paliperidone is combined with Etorphine.Approved
PamabromThe risk or severity of adverse effects can be increased when Etorphine is combined with Pamabrom.Approved
PancuroniumThe risk or severity of adverse effects can be increased when Pancuronium is combined with Etorphine.Approved
ParaldehydeEtorphine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
PargylineThe risk or severity of adverse effects can be increased when Etorphine is combined with Pargyline.Approved
ParoxetineEtorphine may increase the serotonergic activities of Paroxetine.Approved, Investigational
PegvisomantThe therapeutic efficacy of Pegvisomant can be decreased when used in combination with Etorphine.Approved
PenfluridolThe risk or severity of adverse effects can be increased when Etorphine is combined with Penfluridol.Experimental
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Etorphine.Approved, Vet Approved
PentobarbitalThe risk or severity of adverse effects can be increased when Pentobarbital is combined with Etorphine.Approved, Vet Approved
PentoliniumThe risk or severity of adverse effects can be increased when Pentolinium is combined with Etorphine.Approved
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Etorphine.Approved
PerazineThe risk or severity of adverse effects can be increased when Etorphine is combined with Perazine.Investigational
PerospironeThe risk or severity of adverse effects can be increased when Etorphine is combined with Perospirone.Approved
PerphenazineThe risk or severity of adverse effects can be increased when Perphenazine is combined with Etorphine.Approved
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Etorphine.Approved
PhenazocineThe risk or severity of adverse effects can be increased when Etorphine is combined with Phenazocine.Experimental
PhenelzineThe risk or severity of adverse effects can be increased when Etorphine is combined with Phenelzine.Approved
PhenglutarimideThe risk or severity of adverse effects can be increased when Phenglutarimide is combined with Etorphine.Experimental
PhenibutThe risk or severity of adverse effects can be increased when Etorphine is combined with Phenibut.Experimental
PheniprazineThe risk or severity of adverse effects can be increased when Etorphine is combined with Pheniprazine.Withdrawn
PhenobarbitalThe risk or severity of adverse effects can be increased when Phenobarbital is combined with Etorphine.Approved
PhenoperidineThe risk or severity of adverse effects can be increased when Etorphine is combined with Phenoperidine.Experimental
PhenoxyethanolThe risk or severity of adverse effects can be increased when Etorphine is combined with Phenoxyethanol.Approved
PhenoxypropazineThe risk or severity of adverse effects can be increased when Etorphine is combined with Phenoxypropazine.Withdrawn
PhenterminePhentermine may increase the analgesic activities of Etorphine.Approved, Illicit
PhenytoinThe risk or severity of adverse effects can be increased when Etorphine is combined with Phenytoin.Approved, Vet Approved
PimozideThe risk or severity of adverse effects can be increased when Pimozide is combined with Etorphine.Approved
PipamperoneThe risk or severity of adverse effects can be increased when Etorphine is combined with Pipamperone.Approved, Investigational
PipecuroniumThe risk or severity of adverse effects can be increased when Pipecuronium is combined with Etorphine.Approved
PipotiazineThe risk or severity of adverse effects can be increased when Etorphine is combined with Pipotiazine.Approved, Investigational
PirenzepineThe risk or severity of adverse effects can be increased when Pirenzepine is combined with Etorphine.Approved
PiretanideThe risk or severity of adverse effects can be increased when Etorphine is combined with Piretanide.Experimental
PiritramideThe risk or severity of adverse effects can be increased when Etorphine is combined with Piritramide.Investigational
PirlindoleThe risk or severity of adverse effects can be increased when Etorphine is combined with Pirlindole.Approved
PivhydrazineThe risk or severity of adverse effects can be increased when Etorphine is combined with Pivhydrazine.Withdrawn
PizotifenThe risk or severity of adverse effects can be increased when Etorphine is combined with Pizotifen.Approved
PolythiazideThe risk or severity of adverse effects can be increased when Etorphine is combined with Polythiazide.Approved
PomalidomideThe risk or severity of adverse effects can be increased when Etorphine is combined with Pomalidomide.Approved
PotassiumThe risk or severity of adverse effects can be increased when Etorphine is combined with Potassium.Approved
Potassium CitrateThe risk or severity of adverse effects can be increased when Etorphine is combined with Potassium Citrate.Approved, Vet Approved
PramipexoleEtorphine may increase the sedative activities of Pramipexole.Approved, Investigational
PramocaineThe risk or severity of adverse effects can be increased when Etorphine is combined with Pramocaine.Approved
PrazepamThe risk or severity of adverse effects can be increased when Etorphine is combined with Prazepam.Approved, Illicit
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Etorphine.Approved, Illicit, Investigational
PrilocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Etorphine.Approved
PrimidoneThe risk or severity of adverse effects can be increased when Etorphine is combined with Primidone.Approved, Vet Approved
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with Etorphine.Approved, Investigational, Vet Approved
ProcarbazineThe risk or severity of adverse effects can be increased when Etorphine is combined with Procarbazine.Approved
ProchlorperazineThe risk or severity of adverse effects can be increased when Prochlorperazine is combined with Etorphine.Approved, Vet Approved
ProcyclidineThe risk or severity of adverse effects can be increased when Procyclidine is combined with Etorphine.Approved
PromazineThe risk or severity of adverse effects can be increased when Promazine is combined with Etorphine.Approved, Vet Approved
PromethazineThe risk or severity of adverse effects can be increased when Etorphine is combined with Promethazine.Approved
PropanididThe risk or severity of adverse effects can be increased when Etorphine is combined with Propanidid.Experimental
PropanthelineThe risk or severity of adverse effects can be increased when Propantheline is combined with Etorphine.Approved
ProparacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Etorphine.Approved, Vet Approved
PropericiazinePropericiazine may increase the hypotensive activities of Etorphine.Approved
PropiopromazinePropiopromazine may increase the hypotensive activities of Etorphine.Vet Approved
PropiverineThe risk or severity of adverse effects can be increased when Propiverine is combined with Etorphine.Approved, Investigational
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Etorphine.Approved, Investigational, Vet Approved
PropoxycaineThe risk or severity of adverse effects can be increased when Etorphine is combined with Propoxycaine.Approved
ProtriptylineThe risk or severity of adverse effects can be increased when Etorphine is combined with Protriptyline.Approved
ProxibarbalThe risk or severity of adverse effects can be increased when Etorphine is combined with Proxibarbal.Experimental
PSD502The risk or severity of adverse effects can be increased when Etorphine is combined with PSD502.Investigational
PseudoephedrinePseudoephedrine may increase the analgesic activities of Etorphine.Approved
QuazepamThe risk or severity of adverse effects can be increased when Quazepam is combined with Etorphine.Approved, Illicit
QuetiapineThe risk or severity of adverse effects can be increased when Quetiapine is combined with Etorphine.Approved
QuinethazoneThe risk or severity of adverse effects can be increased when Etorphine is combined with Quinethazone.Approved
QuinidineThe risk or severity of adverse effects can be increased when Quinidine is combined with Etorphine.Approved
QuinisocaineThe risk or severity of adverse effects can be increased when Etorphine is combined with Quinisocaine.Experimental
RacloprideThe risk or severity of adverse effects can be increased when Etorphine is combined with Raclopride.Investigational
RamelteonThe risk or severity of adverse effects can be increased when Etorphine is combined with Ramelteon.Approved, Investigational
RamosetronEtorphine may increase the constipating activities of Ramosetron.Approved, Investigational
RasagilineThe risk or severity of adverse effects can be increased when Etorphine is combined with Rasagiline.Approved
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Etorphine.Approved
RemoxiprideThe risk or severity of adverse effects can be increased when Remoxipride is combined with Etorphine.Approved, Withdrawn
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Etorphine.Approved, Investigational
RisperidoneThe risk or severity of adverse effects can be increased when Risperidone is combined with Etorphine.Approved, Investigational
RitanserinThe risk or severity of adverse effects can be increased when Etorphine is combined with Ritanserin.Investigational
RitobegronRitobegron may increase the analgesic activities of Etorphine.Investigational
RolofyllineThe risk or severity of adverse effects can be increased when Etorphine is combined with Rolofylline.Investigational
RomifidineThe risk or severity of adverse effects can be increased when Etorphine is combined with Romifidine.Vet Approved
RopiniroleEtorphine may increase the sedative activities of Ropinirole.Approved, Investigational
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Etorphine.Approved
RotigotineEtorphine may increase the sedative activities of Rotigotine.Approved
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Etorphine.Approved
SafrazineThe risk or severity of adverse effects can be increased when Etorphine is combined with Safrazine.Withdrawn
ScopolamineThe risk or severity of adverse effects can be increased when Etorphine is combined with Scopolamine.Approved
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Etorphine.Approved, Vet Approved
SelegilineThe risk or severity of adverse effects can be increased when Etorphine is combined with Selegiline.Approved, Investigational, Vet Approved
SepranoloneThe risk or severity of adverse effects can be increased when Etorphine is combined with Sepranolone.Investigational
SertindoleThe risk or severity of adverse effects can be increased when Etorphine is combined with Sertindole.Approved, Investigational, Withdrawn
SertralineEtorphine may increase the serotonergic activities of Sertraline.Approved
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Etorphine.Approved, Vet Approved
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Etorphine.Approved
SolifenacinThe risk or severity of adverse effects can be increased when Solifenacin is combined with Etorphine.Approved
SpiradolineThe risk or severity of adverse effects can be increased when Etorphine is combined with Spiradoline.Investigational
SpironolactoneThe risk or severity of adverse effects can be increased when Etorphine is combined with Spironolactone.Approved
StiripentolThe risk or severity of adverse effects can be increased when Etorphine is combined with Stiripentol.Approved
SuccinylcholineSuccinylcholine may increase the bradycardic activities of Etorphine.Approved
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Etorphine.Approved, Investigational
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Etorphine.Approved, Investigational
SultoprideThe risk or severity of adverse effects can be increased when Etorphine is combined with Sultopride.Experimental
SuvorexantEtorphine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.Approved
TandospironeThe risk or severity of adverse effects can be increased when Etorphine is combined with Tandospirone.Investigational
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Etorphine.Approved
TasimelteonThe risk or severity of adverse effects can be increased when Etorphine is combined with Tasimelteon.Approved
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Etorphine.Approved
TetrabenazineThe risk or severity of adverse effects can be increased when Etorphine is combined with Tetrabenazine.Approved
TetracaineThe risk or severity of adverse effects can be increased when Etorphine is combined with Tetracaine.Approved, Vet Approved
TetrahydropalmatineThe risk or severity of adverse effects can be increased when Etorphine is combined with Tetrahydropalmatine.Investigational
TetrodotoxinThe risk or severity of adverse effects can be increased when Etorphine is combined with Tetrodotoxin.Investigational
ThalidomideEtorphine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.Approved, Investigational, Withdrawn
TheobromineThe risk or severity of adverse effects can be increased when Etorphine is combined with Theobromine.Approved, Investigational
ThiamylalThe risk or severity of adverse effects can be increased when Thiamylal is combined with Etorphine.Approved, Vet Approved
ThiazinamThiazinam may increase the hypotensive activities of Etorphine.Experimental
ThiethylperazineThiethylperazine may increase the hypotensive activities of Etorphine.Withdrawn
ThiopentalThe risk or severity of adverse effects can be increased when Thiopental is combined with Etorphine.Approved, Vet Approved
ThioproperazineThioproperazine may increase the hypotensive activities of Etorphine.Approved
ThioridazineThe risk or severity of adverse effects can be increased when Thioridazine is combined with Etorphine.Approved, Withdrawn
ThiothixeneThe risk or severity of adverse effects can be increased when Thiothixene is combined with Etorphine.Approved
TiagabineThe risk or severity of adverse effects can be increased when Etorphine is combined with Tiagabine.Approved
TiaprideThe risk or severity of adverse effects can be increased when Etorphine is combined with Tiapride.Approved, Investigational
TicrynafenThe risk or severity of adverse effects can be increased when Etorphine is combined with Ticrynafen.Withdrawn
TiletamineThe risk or severity of adverse effects can be increased when Etorphine is combined with Tiletamine.Vet Approved
TilidineThe risk or severity of adverse effects can be increased when Etorphine is combined with Tilidine.Experimental
TiotropiumThe risk or severity of adverse effects can be increased when Tiotropium is combined with Etorphine.Approved
TizanidineThe risk or severity of adverse effects can be increased when Etorphine is combined with Tizanidine.Approved
TolcaponeThe risk or severity of adverse effects can be increased when Etorphine is combined with Tolcapone.Approved, Withdrawn
ToloxatoneThe risk or severity of adverse effects can be increased when Etorphine is combined with Toloxatone.Approved
TolterodineThe risk or severity of adverse effects can be increased when Tolterodine is combined with Etorphine.Approved, Investigational
TolvaptanThe risk or severity of adverse effects can be increased when Etorphine is combined with Tolvaptan.Approved
TopiramateThe risk or severity of adverse effects can be increased when Etorphine is combined with Topiramate.Approved
TorasemideThe risk or severity of adverse effects can be increased when Etorphine is combined with Torasemide.Approved
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Etorphine.Approved, Investigational
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Etorphine is combined with Trans-2-Phenylcyclopropylamine.Experimental
TranylcypromineThe risk or severity of adverse effects can be increased when Tranylcypromine is combined with Etorphine.Approved
TrazodoneThe risk or severity of adverse effects can be increased when Trazodone is combined with Etorphine.Approved, Investigational
TriamtereneThe risk or severity of adverse effects can be increased when Etorphine is combined with Triamterene.Approved
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with Etorphine.Approved
Tricaine methanesulfonateThe risk or severity of adverse effects can be increased when Etorphine is combined with Tricaine methanesulfonate.Vet Approved
TrichlormethiazideThe risk or severity of adverse effects can be increased when Etorphine is combined with Trichlormethiazide.Approved, Vet Approved
TrichloroethyleneThe risk or severity of adverse effects can be increased when Etorphine is combined with Trichloroethylene.Approved
TrifluoperazineThe risk or severity of adverse effects can be increased when Trifluoperazine is combined with Etorphine.Approved
TrifluperidolThe risk or severity of adverse effects can be increased when Etorphine is combined with Trifluperidol.Experimental
TriflupromazineThe risk or severity of adverse effects can be increased when Triflupromazine is combined with Etorphine.Approved, Vet Approved
TrihexyphenidylThe risk or severity of adverse effects can be increased when Trihexyphenidyl is combined with Etorphine.Approved
TrimethaphanThe risk or severity of adverse effects can be increased when Trimethaphan is combined with Etorphine.Approved, Investigational
TrimipramineThe risk or severity of adverse effects can be increased when Etorphine is combined with Trimipramine.Approved
TriprolidineThe risk or severity of adverse effects can be increased when Etorphine is combined with Triprolidine.Approved
TropatepineThe risk or severity of adverse effects can be increased when Tropatepine is combined with Etorphine.Experimental
TropicamideThe risk or severity of adverse effects can be increased when Tropicamide is combined with Etorphine.Approved
TrospiumThe risk or severity of adverse effects can be increased when Trospium is combined with Etorphine.Approved
TubocurarineThe risk or severity of adverse effects can be increased when Tubocurarine is combined with Etorphine.Approved
UlaritideThe risk or severity of adverse effects can be increased when Etorphine is combined with Ularitide.Investigational
UmeclidiniumThe risk or severity of adverse effects can be increased when Umeclidinium is combined with Etorphine.Approved
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Etorphine.Approved, Investigational
VecuroniumThe risk or severity of adverse effects can be increased when Vecuronium is combined with Etorphine.Approved
VemurafenibThe risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Etorphine.Approved
VenlafaxineEtorphine may increase the serotonergic activities of Venlafaxine.Approved
VeraliprideThe risk or severity of adverse effects can be increased when Etorphine is combined with Veralipride.Experimental
VigabatrinThe risk or severity of adverse effects can be increased when Etorphine is combined with Vigabatrin.Approved
Vinyl etherThe risk or severity of adverse effects can be increased when Etorphine is combined with Vinyl ether.Experimental
VortioxetineThe risk or severity of adverse effects can be increased when Etorphine is combined with Vortioxetine.Approved
XenonThe risk or severity of adverse effects can be increased when Etorphine is combined with Xenon.Experimental
XipamideThe risk or severity of adverse effects can be increased when Etorphine is combined with Xipamide.Experimental
XylazineThe risk or severity of adverse effects can be increased when Etorphine is combined with Xylazine.Vet Approved
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with Etorphine.Approved, Illicit, Investigational
ZiconotideThe risk or severity of adverse effects can be increased when Etorphine is combined with Ziconotide.Approved
ZimelidineEtorphine may increase the serotonergic activities of Zimelidine.Withdrawn
ZiprasidoneThe risk or severity of adverse effects can be increased when Ziprasidone is combined with Etorphine.Approved
ZolazepamThe risk or severity of adverse effects can be increased when Etorphine is combined with Zolazepam.Vet Approved
ZolpidemEtorphine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.Approved
ZonisamideThe risk or severity of adverse effects can be increased when Etorphine is combined with Zonisamide.Approved, Investigational
ZopicloneThe risk or severity of adverse effects can be increased when Zopiclone is combined with Etorphine.Approved
ZotepineThe risk or severity of adverse effects can be increased when Etorphine is combined with Zotepine.Approved, Investigational
ZuclopenthixolThe risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Etorphine.Approved, Investigational
Food Interactions
Not Available

References

General References
Not Available
External Links
KEGG Compound
C11793
PubChem Compound
26721
PubChem Substance
46505591
ChemSpider
24895
ChEBI
4912
Therapeutic Targets Database
DNC000631
Wikipedia
Etorphine

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)214-217 °CPhysProp
logP2.79SANGSTER (1993)
Predicted Properties
PropertyValueSource
Water Solubility0.112 mg/mLALOGPS
logP3.29ALOGPS
logP2.47ChemAxon
logS-3.6ALOGPS
pKa (Strongest Acidic)7.48ChemAxon
pKa (Strongest Basic)11.72ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area62.16 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity116.51 m3·mol-1ChemAxon
Polarizability45.55 Å3ChemAxon
Number of Rings6ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9954
Blood Brain Barrier+0.9708
Caco-2 permeable+0.7322
P-glycoprotein substrateSubstrate0.9173
P-glycoprotein inhibitor IInhibitor0.7399
P-glycoprotein inhibitor IINon-inhibitor0.7779
Renal organic cation transporterNon-inhibitor0.6479
CYP450 2C9 substrateNon-substrate0.8713
CYP450 2D6 substrateSubstrate0.7349
CYP450 3A4 substrateSubstrate0.7858
CYP450 1A2 substrateNon-inhibitor0.9392
CYP450 2C9 inhibitorNon-inhibitor0.8992
CYP450 2D6 inhibitorNon-inhibitor0.6197
CYP450 2C19 inhibitorNon-inhibitor0.8553
CYP450 3A4 inhibitorNon-inhibitor0.8272
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9294
Ames testNon AMES toxic0.7862
CarcinogenicityNon-carcinogens0.9372
BiodegradationNot ready biodegradable0.9973
Rat acute toxicity3.2955 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8072
hERG inhibition (predictor II)Non-inhibitor0.7219
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as morphinans. These are polycyclic compounds with a four-ring skeleton with three condensed six-member rings forming a partially hydrogenated phenanthrene moiety, one of which is aromatic while the two others are alicyclic.
Kingdom
Organic compounds
Super Class
Alkaloids and derivatives
Class
Morphinans
Sub Class
Not Available
Direct Parent
Morphinans
Alternative Parents
Phenanthrenes and derivatives / Tetralins / Azaspirodecane derivatives / Coumarans / Aralkylamines / Alkyl aryl ethers / 1-hydroxy-2-unsubstituted benzenoids / Piperidines / Tertiary alcohols / Trialkylamines
show 5 more
Substituents
Morphinan / Phenanthrene / Azaspirodecane / Tetralin / Coumaran / Alkyl aryl ether / 1-hydroxy-2-unsubstituted benzenoid / Aralkylamine / Piperidine / Benzenoid
show 17 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
Not Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Agonist
General Function
Voltage-gated calcium channel activity
Specific Function
Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone...
Gene Name
OPRM1
Uniprot ID
P35372
Uniprot Name
Mu-type opioid receptor
Molecular Weight
44778.855 Da
References
  1. Duttaroy A, Yoburn BC: In vivo regulation of mu-opioid receptor density and gene expression in CXBK and outbred Swiss Webster mice. Synapse. 2000 Aug;37(2):118-24. [PubMed:10881033]
  2. Melone M, Brecha NC, Sternini C, Evans C, Conti F: Etorphine increases the number of mu-opioid receptor-positive cells in the cerebral cortex. Neuroscience. 2000;100(3):439-43. [PubMed:11098106]
  3. Stafford K, Gomes AB, Shen J, Yoburn BC: mu-Opioid receptor downregulation contributes to opioid tolerance in vivo. Pharmacol Biochem Behav. 2001 May-Jun;69(1-2):233-7. [PubMed:11420091]
  4. Gomes BA, Shen J, Stafford K, Patel M, Yoburn BC: Mu-opioid receptor down-regulation and tolerance are not equally dependent upon G-protein signaling. Pharmacol Biochem Behav. 2002 May;72(1-2):273-8. [PubMed:11900797]
  5. Patel MB, Patel CN, Rajashekara V, Yoburn BC: Opioid agonists differentially regulate mu-opioid receptors and trafficking proteins in vivo. Mol Pharmacol. 2002 Dec;62(6):1464-70. [PubMed:12435815]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Agonist
General Function
Opioid receptor activity
Specific Function
G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine n...
Gene Name
OPRD1
Uniprot ID
P41143
Uniprot Name
Delta-type opioid receptor
Molecular Weight
40368.235 Da
References
  1. Li JG, Benovic JL, Liu-Chen LY: Mechanisms of agonist-induced down-regulation of the human kappa-opioid receptor: internalization is required for down-regulation. Mol Pharmacol. 2000 Oct;58(4):795-801. [PubMed:10999950]
  2. Li JG, Zhang F, Jin XL, Liu-Chen LY: Differential regulation of the human kappa opioid receptor by agonists: etorphine and levorphanol reduced dynorphin A- and U50,488H-induced internalization and phosphorylation. J Pharmacol Exp Ther. 2003 May;305(2):531-40. Epub 2003 Jan 24. [PubMed:12606694]
  3. Marie N, Lecoq I, Jauzac P, Allouche S: Differential sorting of human delta-opioid receptors after internalization by peptide and alkaloid agonists. J Biol Chem. 2003 Jun 20;278(25):22795-804. Epub 2003 Apr 2. [PubMed:12672796]
  4. Sumner BE, Douglas AJ, Russell JA: Pregnancy alters the density of opioid binding sites in the supraoptic nucleus and posterior pituitary gland of rats. Neurosci Lett. 1992 Mar 30;137(2):216-20. [PubMed:1316589]
  5. Tao PL, Tsai CL, Chang LR, Loh HH: Chronic effect of [D-Pen2,D-Pen5]enkephalin on rat brain opioid receptors. Eur J Pharmacol. 1991 Aug 29;201(2-3):209-14. [PubMed:1665782]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352]
  7. Niwa M, al-Essa LY, Ohta S, Kohno K, Nozaki M, Tsurumi K, Iwamura T, Kataoka T: Opioid receptor interaction and adenylyl cyclase inhibition of dihydroetorphine: direct comparison with etorphine. Life Sci. 1995;56(21):PL395-400. [PubMed:7739347]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Agonist
General Function
Opioid receptor activity
Specific Function
G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synt...
Gene Name
OPRK1
Uniprot ID
P41145
Uniprot Name
Kappa-type opioid receptor
Molecular Weight
42644.665 Da
References
  1. Niwa M, al-Essa LY, Ohta S, Kohno K, Nozaki M, Tsurumi K, Iwamura T, Kataoka T: Opioid receptor interaction and adenylyl cyclase inhibition of dihydroetorphine: direct comparison with etorphine. Life Sci. 1995;56(21):PL395-400. [PubMed:7739347]
  2. Wannemacher KM, Yadav PN, Howells RD: A select set of opioid ligands induce up-regulation by promoting the maturation and stability of the rat kappa-opioid receptor in human embryonic kidney 293 cells. J Pharmacol Exp Ther. 2007 Nov;323(2):614-25. Epub 2007 Aug 24. [PubMed:17720886]
  3. Gharagozlou P, Hashemi E, DeLorey TM, Clark JD, Lameh J: Pharmacological profiles of opioid ligands at kappa opioid receptors. BMC Pharmacol. 2006 Jan 25;6:3. [PubMed:16433932]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Agonist
General Function
Nociceptin receptor activity
Specific Function
G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-b...
Gene Name
OPRL1
Uniprot ID
P41146
Uniprot Name
Nociceptin receptor
Molecular Weight
40692.775 Da
References
  1. Hawkinson JE, Acosta-Burruel M, Espitia SA: Opioid activity profiles indicate similarities between the nociceptin/orphanin FQ and opioid receptors. Eur J Pharmacol. 2000 Feb 18;389(2-3):107-14. [PubMed:10688973]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Agonist
General Function
Zinc ion binding
Specific Function
E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process ac...
Gene Name
TRIM13
Uniprot ID
O60858
Uniprot Name
E3 ubiquitin-protein ligase TRIM13
Molecular Weight
46987.08 Da
References
  1. Maneckjee R, Archer S, Zukin RS: Characterization of a polyclonal antibody to the mu opioid receptor. J Neuroimmunol. 1988 Feb;17(3):199-208. [PubMed:2828423]
  2. Stojilkovic SS, Dufau ML, Catt KJ: Opiate receptor subtypes in the rat hypothalamus and neurointermediate lobe. Endocrinology. 1987 Jul;121(1):384-94. [PubMed:3036471]
  3. Pesce G, Lang MA, Russell JT, Rodbard D, Gainer H: Characterization of kappa opioid receptors in neurosecretosomes from bovine posterior pituitary. J Neurochem. 1987 Aug;49(2):421-7. [PubMed:3037028]
  4. Pfeiffer A, Herz A: Discrimination of three opiate receptor binding sites with the use of a computerized curve-fitting technique. Mol Pharmacol. 1982 Mar;21(2):266-71. [PubMed:6124875]
  5. Audigier Y, Mazarguil H, Gout R, Cros J: Structure-activity relationships of enkephalin analogs at opiate and enkephalin receptors: correlation with analgesia. Eur J Pharmacol. 1980 Apr 11;63(1):35-46. [PubMed:6247160]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Type 4 melanocortin receptor binding
Specific Function
ACTH stimulates the adrenal glands to release cortisol.MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes.Beta-endorphin and Met...
Gene Name
POMC
Uniprot ID
P01189
Uniprot Name
Pro-opiomelanocortin
Molecular Weight
29423.72 Da
References
  1. Sanchez-Blazquez P, Garzon J: Further characterization of alpha N-acetyl beta-endorphin-(1-31) regulatory activity, I: Effect on opioid- and alpha 2-mediated supraspinal antinociception in mice. Life Sci. 1992;50(26):2083-97. [PubMed:1318989]
  2. Xu JY, Fujimoto JM, Tseng LF: Involvement of supraspinal epsilon and mu opioid receptors in inhibition of the tail-flick response induced by etorphine in the mouse. J Pharmacol Exp Ther. 1992 Oct;263(1):246-52. [PubMed:1328609]
  3. Nicolas P, Li CH: Beta-endorphin-(1-27) is a naturally occurring antagonist to etorphine-induced analgesia. Proc Natl Acad Sci U S A. 1985 May;82(10):3178-81. [PubMed:2987913]
  4. Dum J, Gramsch C, Herz A: Activation of hypothalamic beta-endorphin pools by reward induced by highly palatable food. Pharmacol Biochem Behav. 1983 Mar;18(3):443-7. [PubMed:6132412]
  5. Lemaire S, Livett B, Tseng R, Mercier P, Lemaire I: Studies on the inhibitory action of opiate compounds in isolated bovine adrenal chromaffin cells: noninvolvement of stereospecific opiate binding sites. J Neurochem. 1981 Mar;36(3):886-92. [PubMed:6259293]

Drug created on July 31, 2007 07:09 / Updated on December 01, 2017 17:17