Dextrorphan
Star0
This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Dextrorphan
- DrugBank Accession Number
- DB14682
- Background
Not Available
- Type
- Small Molecule
- Groups
- Experimental
- Structure
- Weight
- Average: 257.3706
Monoisotopic: 257.177964363 - Chemical Formula
- C17H23NO
- Synonyms
- (+)-dextrorphan
- (+)-N-methylmorphinan-3-ol
- d-3-hydroxy-N-methylmorphinan
- Dextro-dromoran
- Dextrorphan
- Dextrorphane
- Dextrorphanum
- Levorphanol D-form
- External IDs
- RO 1-6794
- RO-1-6794
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Alkaloids
- Central Nervous System Agents
- Compounds used in a research, industrial, or household setting
- Excitatory Amino Acid Agents
- Excitatory Amino Acid Antagonists
- Heterocyclic Compounds, Fused-Ring
- Morphinans
- Neuroprotective Agents
- Neurotransmitter Agents
- Opiate Alkaloids
- Phenanthrenes
- Protective Agents
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 04B7QNO9WS
- CAS number
- 125-73-5
- InChI Key
- JAQUASYNZVUNQP-PVAVHDDUSA-N
- InChI
- InChI=1S/C17H23NO/c1-18-9-8-17-7-3-2-4-14(17)16(18)10-12-5-6-13(19)11-15(12)17/h5-6,11,14,16,19H,2-4,7-10H2,1H3/t14-,16+,17+/m1/s1
- IUPAC Name
- (1S,9S,10S)-17-methyl-17-azatetracyclo[7.5.3.0^{1,10}.0^{2,7}]heptadeca-2(7),3,5-trien-4-ol
- SMILES
- [H][C@]12CC3=C(C=C(O)C=C3)[C@@]3(CCCC[C@]13[H])CCN2C
References
- General References
- Not Available
- External Links
- Human Metabolome Database
- HMDB0060552
- ChemSpider
- 10489895
- BindingDB
- 50001000
- ChEBI
- 29133
- ChEMBL
- CHEMBL1254766
- ZINC
- ZINC000001280092
- Wikipedia
- Dextrorphan
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.173 mg/mL ALOGPS logP 3.29 ALOGPS logP 2.9 Chemaxon logS -3.2 ALOGPS pKa (Strongest Acidic) 10.46 Chemaxon pKa (Strongest Basic) 9.66 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 23.47 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 78.08 m3·mol-1 Chemaxon Polarizability 29.79 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 166.4166924 predictedDarkChem Lite v0.1.0 [M-H]- 169.14603 predictedDeepCCS 1.0 (2019) [M+H]+ 166.1416924 predictedDarkChem Lite v0.1.0 [M+H]+ 171.50403 predictedDeepCCS 1.0 (2019) [M+Na]+ 166.5775924 predictedDarkChem Lite v0.1.0 [M+Na]+ 177.93642 predictedDeepCCS 1.0 (2019)
Drug created at September 05, 2018 19:17 / Updated at February 21, 2021 18:54