Expectorants

Agents that increase mucous excretion. Mucolytic agents, that is drugs that liquefy mucous secretions, are also included here.
DrugDrug NameDrug Indication
DB00874GuaifenesinUsed to assist the expectoration of phlegm from the airways in acute respiratory tract infections.
DB01423SteproninStrepronin is a mucolytic (expectorant) drug.
DB04339CarbocisteineUsed to help relieve the symptoms of chronic obstructive pulmonary disorder (COPD) and bronchiectasis.
DB05057ErdosteineFro the treatment of chronic bronchitis in adults.
DB06742AmbroxolAmbroxol is indicated as “secretolytic therapy in bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport. It promotes mucus clearance, facilitates expectoration and eases productive cough, allowing patients to breathe freely and deeply.
DB08939LetosteineNot Available
DB08990EprazinoneNot Available
DB09019BromhexineNot Available
DB06151AcetylcysteineAcetylcysteine is used mainly as a mucolytic and in the management of paracetamol (acetaminophen) overdose.
DB09125Potassium CitrateFor the management of renal tubular acidosis, hypocitraturic calcium oxalate nephrolithiasis, and uric acid lithiasis with or without calcium stones.
DB13163Terpin hydrateTerpin hydrate is an expectorant, used in the treatment of acute and chronic bronchitis, pneumonia, bronchiectasis, chronic obstructive pulmonary disease, infectious and inflammatory diseases of the upper respiratory tract. It is typically formulated with an antitussive (e.g., codeine) as a combined preparation.
DB00003Dornase alfaUsed as adjunct therapy in the treatment of cystic fibrosis.
DB00742MannitolUsed for the promotion of diuresis before irreversible renal failure becomes established, the reduction of intracranial pressure, the treatment of cerebral edema, and the promotion of urinary excretion of toxic substances.
DB03852EucalyptolNot Available
DB06439TyloxapolUsed as a surfactant to aid liquefaction and removal of mucopurulent (containing mucus and pus) bronchopulmonary secretions, administered by inhalation through a nebulizer or with a stream of oxygen. Also investigated for use/treatment in cystic fibrosis and pediatric indications.
DB06823TioproninTiopronin is indicated for the prevention of kidney stone formation in patients with severe homozygous cystinuria consisting of a urinary cystine concentration greater than 500 mg/day, and who have failed treatment with non-pharmacological measures of increased fluid intake, decreased sodium and protein intake, and urine alkalinization.
DB13293IpecacuanhaNot Available
DB13735GuaiacolsulfonateNot Available
DB00514DextromethorphanFor treatment and relief of dry cough.
DB06715Potassium IodidePotassium Iodide is oral antithyroid agent. Potassium Iodide is used as an adjunct to other antithyroid agents in the treatment of hyperthyroidism and thyrotoxicosis and preoperatively to induce thyroid involution.
DrugDrug NameTargetType
DB04339CarbocisteineGlutathione S-transferase Ptarget
DB05057ErdosteineAdenosine deaminaseenzyme
DB06742AmbroxolCytochrome P450 3A4enzyme
DB06151AcetylcysteineSolute carrier organic anion transporter family member 1B1transporter
DB06151AcetylcysteineNAPQI (N-acetyl-p-benzoquinone imine)target
DB06151AcetylcysteineSolute carrier family 22 member 6transporter
DB06151AcetylcysteineAminoacylase-1target
DB06151AcetylcysteineInhibitor of nuclear factor kappa-B kinase subunit alphatarget
DB06151AcetylcysteineInhibitor of nuclear factor kappa-B kinase subunit betatarget
DB06151AcetylcysteineGlutathione synthetasetarget
DB06151AcetylcysteineCystine/glutamate transportertarget
DB06151AcetylcysteineGlutamate receptor ionotropic, NMDA 2Btarget
DB06151AcetylcysteineGlutamate receptor ionotropic, NMDA 1target
DB06151AcetylcysteineGlutamate receptor ionotropic, NMDA 2Atarget
DB06151AcetylcysteineGlutamate receptor ionotropic, NMDA 2Dtarget
DB06151AcetylcysteineGlutamate receptor ionotropic, NMDA 3Atarget
DB00003Dornase alfaDNAtarget
DB00742MannitolMultidrug resistance protein 1transporter
DB00742MannitolMannitol dehydrogenaseenzyme
DB06439TyloxapolLipoprotein lipasetarget
DB06823TioproninMyeloperoxidaseenzyme
DB00514DextromethorphanSigma non-opioid intracellular receptor 1target
DB00514DextromethorphanHCG20471, isoform CRA_ctarget
DB00514DextromethorphanNeuronal acetylcholine receptor subunit alpha-2target
DB00514DextromethorphanSodium-dependent serotonin transportertarget
DB00514DextromethorphanGlutamate receptor ionotropic, NMDA 3Atarget
DB00514DextromethorphanCytochrome P450 2D6enzyme
DB00514DextromethorphanCytochrome P450 3A4enzyme
DB00514DextromethorphanCytochrome P450 3A5enzyme
DB00514DextromethorphanCytochrome P450 3A7enzyme
DB00514DextromethorphanMultidrug resistance protein 1transporter
DB00514DextromethorphanCytochrome P450 2C9enzyme
DB00514DextromethorphanCytochrome P450 2B6enzyme
DB00514DextromethorphanCytochrome P450 2C19enzyme
DB00514DextromethorphanCytochrome P450 2C8enzyme
DB00514DextromethorphanCytochrome P450 2E1enzyme
DB00514DextromethorphanMembrane-associated progesterone receptor component 1target
DB00514DextromethorphanNeuronal acetylcholine receptor subunit alpha-3target
DB00514DextromethorphanNeuronal acetylcholine receptor subunit alpha-4target
DB00514DextromethorphanNeuronal acetylcholine receptor subunit beta-4target
DB00514DextromethorphanNeuronal acetylcholine receptor subunit beta-2target
DB00514DextromethorphanNeuronal acetylcholine receptor subunit alpha-7target
DB00514DextromethorphanMu-type opioid receptortarget
DB00514DextromethorphanDelta-type opioid receptortarget
DB00514DextromethorphanKappa-type opioid receptortarget
DB00514DextromethorphanNADPH oxidasetarget
DB00514DextromethorphanSodium-dependent noradrenaline transportertarget
DB06715Potassium IodideTyrosinetarget