Surface-Active Agents

Agents that modify interfacial tension of water; usually substances that have one lipophilic and one hydrophilic group in the molecule; includes soaps, detergents, emulsifiers, dispersing and wetting agents, and several groups of antiseptics.
DrugDrug NameDrug Description
DB00464Sodium tetradecyl sulfateAn anionic surfactant used to treat varicose veins of the lower extremities.
DB00815Sodium lauryl sulfateAn anionic surfactant used in cosmetics and pharmaceuticals as a fat emulsifier, wetting agent, and detergent.
DB02123Glycochenodeoxycholic AcidA bile salt formed in the liver from chenodeoxycholate and glycine, usually as the sodium salt. It acts as a detergent to solubilize fats for absorption and is itself absorbed....
DB02643N-Dodecyl-N,N-Dimethyl-3-Ammonio-1-PropanesulfonateNot Available
DB03967Dodecyl sulfateNot Available
DB04348Taurocholic acidThe product of conjugation of cholic acid with taurine. Its sodium salt is the chief ingredient of the bile of carnivorous animals. It acts as a detergent to solubilize fats...
DB04664Cyclohexyl-pentyl-maltosideNot Available
DB06439TyloxapolTyloxapol is an inhaled surfactant that assists in removing and liquefying and removing bronchopulmonary secretions with mucus and pus. Tyloxapol is administered either through nebulized solution or a stream of...
DB06804Nonoxynol-9A vaginal spermicide used for the non-hormonal contraception in conjunction with other modes of contraception.
DB06811PolidocanolA sclerosing agent used for the treatment of uncomplicated spider veins and uncomplicated reticular veins, all less than 3 mm in diameter, in the lower extremity.
DB08833Taurochenodeoxycholic acidTaurochenodeoxycholic acid is likely indicated as a choleretic and cholagogue. It is also being investigated for its role in inflammation and cancer therapy.
DB09287Polyethylene glycolA laxative used to treat constipation and used for bowel preparation before colonoscopies and other procedures.
DB09512SimethiconeAn anti-flatulence agent used to relieve pressure, bloating, and symptoms referred to as gas.
DB11063Polysorbate 80It is used as a solubilizer, antimicrobial preservative and disinfectant .
DB11073CetylpyridiniumA compound used to reduce plaque and gingivitis, as well as whiten teeth.
DB11089DocusateA medication used to treat constipation associated with dry, hard stools, or opioid induced constipation.
DB11105BenzalkoniumAn antiseptic agent used as a preservative in medications or as a disinfectant in cleaning products.
DB11178Polysorbate 20Polysorbate 20 is a polysorbate-type nonionic surfactant used in many commercial, household and pharmaceutical products. It is composed of 20 repeated units of polyethylene glycol via ethoxylation. Polysorbate 20 is...
DB11252Poloxamer 407Poloxamer 407 is a polyoxyethylene polymer and hydrophilic non-ionic surfactant. It consists of a central hydrophobic block of polypropylene glycol that is flanked on each side by polyethylene glycol blocks,...
DB11333Poloxamer 188A medication used to clean wounds.
DB11350Cocamidopropyl betaineCocamidopropyl betaine is a mixture of closely related organic compounds derived from coconut oil and dimethylaminopropylamine that typically acts as an amphoteric surfactant in cosmetics and personal care products. It...
DB11451PoloxaleneEthylene oxide/propylene oxide copolymer is used as a food additive. It belongs to the family of Epoxides. These are compounds containing a cyclic ether with three ring atoms (one oxygen...
DB11583CetalkoniumAn antiseptic used as a preservative or to treat certain topical infections.
DB14143DistearyldimoniumNot Annotated
DB06415CalfactantA lung surfactant for the prophylaxis of respiratory distress syndrome in high-risk infants.
DB06761BeractantA pulmonary surfactant used for the treatment and prevention of Respiratory Distress Syndrome (RDS) in premature infants.
DB09113Poractant alfaA pulmonary surfactant used for the treatment of Respiratory Distress Syndrome (RDS) in premature infants.
DB02691Glycocholic acidThe glycine conjugate of cholic acid. It acts as a detergent to solubilize fats for absorption and is itself absorbed.
DrugDrug NameTargetType
DB00464Sodium tetradecyl sulfateVitamin K-dependent protein Ctarget
DB00464Sodium tetradecyl sulfateVitamin K-dependent protein Starget
DB00815Sodium lauryl sulfateSerum albumincarrier
DB02123Glycochenodeoxycholic Acid7-alpha-hydroxysteroid dehydrogenasetarget
DB02123Glycochenodeoxycholic AcidBile salt export pumptransporter
DB02123Glycochenodeoxycholic AcidSolute carrier organic anion transporter family member 1A2transporter
DB02123Glycochenodeoxycholic AcidIleal sodium/bile acid cotransportertransporter
DB02123Glycochenodeoxycholic AcidSodium/bile acid cotransportertransporter
DB02643N-Dodecyl-N,N-Dimethyl-3-Ammonio-1-PropanesulfonatePenton proteintarget
DB02643N-Dodecyl-N,N-Dimethyl-3-Ammonio-1-PropanesulfonateInsulin-like growth factor Itarget
DB02643N-Dodecyl-N,N-Dimethyl-3-Ammonio-1-PropanesulfonateAmine oxidase [flavin-containing] Btarget
DB03967Dodecyl sulfateLysozyme Ctarget
DB03967Dodecyl sulfateLipid A palmitoyltransferase PagPtarget
DB04348Taurocholic acidBile salt-activated lipasetarget
DB04348Taurocholic acidGastrotropintarget
DB04348Taurocholic acidBile salt export pumptransporter
DB04348Taurocholic acidMultidrug resistance-associated protein 1transporter
DB04348Taurocholic acidSolute carrier organic anion transporter family member 1A2transporter
DB04348Taurocholic acidIleal sodium/bile acid cotransportertransporter
DB04348Taurocholic acidCanalicular multispecific organic anion transporter 1transporter
DB04348Taurocholic acidSolute carrier organic anion transporter family member 1B1transporter
DB04348Taurocholic acidCanalicular multispecific organic anion transporter 2transporter
DB04348Taurocholic acidMultidrug resistance-associated protein 4transporter
DB04348Taurocholic acidP-glycoprotein 1transporter
DB04348Taurocholic acidSolute carrier family 22 member 6transporter
DB04348Taurocholic acidMultidrug resistance-associated protein 7transporter
DB04348Taurocholic acidSolute carrier family 22 member 8transporter
DB04348Taurocholic acidSolute carrier organic anion transporter family member 4A1transporter
DB04348Taurocholic acidATP-binding cassette sub-family C member 11transporter
DB04348Taurocholic acidSolute carrier organic anion transporter family member 1C1transporter
DB04348Taurocholic acidSolute carrier organic anion transporter family member 3A1transporter
DB04348Taurocholic acidATP-binding cassette sub-family G member 2transporter
DB04348Taurocholic acidSolute carrier organic anion transporter family member 2B1transporter
DB04348Taurocholic acidMonocarboxylate transporter 1transporter
DB04348Taurocholic acidSodium/bile acid cotransportertransporter
DB04348Taurocholic acidOrganic solute transporter subunit alphatransporter
DB04348Taurocholic acidOrganic solute transporter subunit betatransporter
DB04348Taurocholic acidSolute carrier organic anion transporter family member 1B3transporter
DB04348Taurocholic acidCystine/glutamate transportertransporter
DB04348Taurocholic acidBile acid receptortarget
DB04664Cyclohexyl-pentyl-maltosideCytochrome P450 2B6target
DB06439TyloxapolLipoprotein lipasetarget
DB06804Nonoxynol-9Prostaglandin G/H synthase 2enzyme
DB08833Taurochenodeoxycholic acidSolute carrier organic anion transporter family member 1A2transporter
DB08833Taurochenodeoxycholic acidCystine/glutamate transportertransporter
DB08833Taurochenodeoxycholic acidCytochrome P450 3A4enzyme
DB02691Glycocholic acidGastrotropintarget
DB02691Glycocholic acidSolute carrier organic anion transporter family member 1A2transporter
DB02691Glycocholic acidSolute carrier organic anion transporter family member 1B1transporter
DB02691Glycocholic acidSolute carrier organic anion transporter family member 1B3transporter