Surface-Active Agents

Name
Surface-Active Agents
Accession Number
DBCAT000898
Description

Agents that modify interfacial tension of water; usually substances that have one lipophilic and one hydrophilic group in the molecule; includes soaps, detergents, emulsifiers, dispersing and wetting agents, and several groups of antiseptics.

Drugs
DrugDrug Description
Sodium tetradecyl sulfateAn anionic surfactant used to treat varicose veins of the lower extremities.
Sodium lauryl sulfateAn anionic surfactant used in cosmetics and pharmaceuticals as a fat emulsifier, wetting agent, and detergent.
Glycochenodeoxycholic AcidA bile salt formed in the liver from chenodeoxycholate and glycine, usually as the sodium salt. It acts as a detergent to solubilize fats for absorption and is itself absorbed....
N-Dodecyl-N,N-Dimethyl-3-Ammonio-1-PropanesulfonateNot Available
Dodecyl sulfateNot Available
Taurocholic acidThe product of conjugation of cholic acid with taurine. Its sodium salt is the chief ingredient of the bile of carnivorous animals. It acts as a detergent to solubilize fats...
Cyclohexyl-pentyl-maltosideNot Available
TyloxapolTyloxapol is an inhaled surfactant that assists in removing and liquefying and removing bronchopulmonary secretions with mucus and pus. Tyloxapol is administered either through nebulized solution or a stream of...
Nonoxynol-9A vaginal spermicide used for the non-hormonal contraception in conjunction with other modes of contraception.
PolidocanolA sclerosing agent used for the treatment of uncomplicated spider veins and uncomplicated reticular veins, all less than 3 mm in diameter, in the lower extremity.
Taurochenodeoxycholic acidTaurochenodeoxycholic acid is likely indicated as a choleretic and cholagogue. It is also being investigated for its role in inflammation and cancer therapy.
Polyethylene glycolA laxative used to treat constipation and used for bowel preparation before colonoscopies and other procedures.
SimethiconeAn anti-flatulence agent used to relieve pressure, bloating, and symptoms referred to as gas.
Polysorbate 80It is used as a solubilizer, antimicrobial preservative and disinfectant .
CetylpyridiniumA compound used to reduce plaque and gingivitis, as well as whiten teeth.
DocusateA medication used to treat constipation associated with dry, hard stools, or opioid induced constipation.
BenzalkoniumAn antiseptic agent used as a preservative in medications or as a disinfectant in cleaning products.
Polysorbate 20Polysorbate 20 is a polysorbate-type nonionic surfactant used in many commercial, household and pharmaceutical products. It is composed of 20 repeated units of polyethylene glycol via ethoxylation. Polysorbate 20 is...
Poloxamer 407Poloxamer 407 is a polyoxyethylene polymer and hydrophilic non-ionic surfactant. It consists of a central hydrophobic block of polypropylene glycol that is flanked on each side by polyethylene glycol blocks,...
Poloxamer 188A medication used to clean wounds.
Cocamidopropyl betaineCocamidopropyl betaine is a mixture of closely related organic compounds derived from coconut oil and dimethylaminopropylamine that typically acts as an amphoteric surfactant in cosmetics and personal care products. It...
PoloxaleneEthylene oxide/propylene oxide copolymer is used as a food additive. It belongs to the family of Epoxides. These are compounds containing a cyclic ether with three ring atoms (one oxygen...
CetalkoniumAn antiseptic used as a preservative or to treat certain topical infections.
DistearyldimoniumNot Annotated
CalfactantA lung surfactant for the prophylaxis of respiratory distress syndrome in high-risk infants.
BeractantA pulmonary surfactant used for the treatment and prevention of Respiratory Distress Syndrome (RDS) in premature infants.
Poractant alfaA pulmonary surfactant used for the treatment of Respiratory Distress Syndrome (RDS) in premature infants.
Glycocholic acidThe glycine conjugate of cholic acid. It acts as a detergent to solubilize fats for absorption and is itself absorbed.
DodecyltrimethylammoniumNot Available
Dodecyldimethylamine N-oxideNot Available
Drugs & Drug Targets
DrugTargetType
Sodium tetradecyl sulfateVitamin K-dependent protein Ctarget
Sodium tetradecyl sulfateVitamin K-dependent protein Starget
Sodium lauryl sulfateSerum albumincarrier
Glycochenodeoxycholic Acid7-alpha-hydroxysteroid dehydrogenasetarget
Glycochenodeoxycholic AcidBile salt export pumptransporter
Glycochenodeoxycholic AcidSolute carrier organic anion transporter family member 1A2transporter
Glycochenodeoxycholic AcidIleal sodium/bile acid cotransportertransporter
Glycochenodeoxycholic AcidSodium/bile acid cotransportertransporter
N-Dodecyl-N,N-Dimethyl-3-Ammonio-1-PropanesulfonatePenton proteintarget
N-Dodecyl-N,N-Dimethyl-3-Ammonio-1-PropanesulfonateInsulin-like growth factor Itarget
N-Dodecyl-N,N-Dimethyl-3-Ammonio-1-PropanesulfonateAmine oxidase [flavin-containing] Btarget
Dodecyl sulfateLysozyme Ctarget
Dodecyl sulfateLipid A palmitoyltransferase PagPtarget
Taurocholic acidBile salt-activated lipasetarget
Taurocholic acidGastrotropintarget
Taurocholic acidBile salt export pumptransporter
Taurocholic acidMultidrug resistance-associated protein 1transporter
Taurocholic acidSolute carrier organic anion transporter family member 1A2transporter
Taurocholic acidIleal sodium/bile acid cotransportertransporter
Taurocholic acidCanalicular multispecific organic anion transporter 1transporter
Taurocholic acidSolute carrier organic anion transporter family member 1B1transporter
Taurocholic acidCanalicular multispecific organic anion transporter 2transporter
Taurocholic acidMultidrug resistance-associated protein 4transporter
Taurocholic acidP-glycoprotein 1transporter
Taurocholic acidSolute carrier family 22 member 6transporter
Taurocholic acidMultidrug resistance-associated protein 7transporter
Taurocholic acidSolute carrier family 22 member 8transporter
Taurocholic acidSolute carrier organic anion transporter family member 4A1transporter
Taurocholic acidATP-binding cassette sub-family C member 11transporter
Taurocholic acidSolute carrier organic anion transporter family member 1C1transporter
Taurocholic acidSolute carrier organic anion transporter family member 3A1transporter
Taurocholic acidATP-binding cassette sub-family G member 2transporter
Taurocholic acidSolute carrier organic anion transporter family member 2B1transporter
Taurocholic acidMonocarboxylate transporter 1transporter
Taurocholic acidSodium/bile acid cotransportertransporter
Taurocholic acidOrganic solute transporter subunit alphatransporter
Taurocholic acidOrganic solute transporter subunit betatransporter
Taurocholic acidSolute carrier organic anion transporter family member 1B3transporter
Taurocholic acidCystine/glutamate transportertransporter
Taurocholic acidBile acid receptortarget
Cyclohexyl-pentyl-maltosideCytochrome P450 2B6target
TyloxapolLipoprotein lipasetarget
Nonoxynol-9Prostaglandin G/H synthase 2enzyme
Taurochenodeoxycholic acidSolute carrier organic anion transporter family member 1A2transporter
Taurochenodeoxycholic acidCystine/glutamate transportertransporter
Taurochenodeoxycholic acidCytochrome P450 3A4enzyme
Polyethylene glycolP-glycoprotein 1transporter
Glycocholic acidGastrotropintarget
Glycocholic acidSolute carrier organic anion transporter family member 1A2transporter
Glycocholic acidSolute carrier organic anion transporter family member 1B1transporter
Glycocholic acidSolute carrier organic anion transporter family member 1B3transporter
DodecyltrimethylammoniumTyrosine-protein phosphatase non-receptor type 11target
Dodecyldimethylamine N-oxideFe(3+) dicitrate transport protein FecAtarget
Dodecyldimethylamine N-oxideLong-chain fatty acid transport proteintarget
Dodecyldimethylamine N-oxideLipid A palmitoyltransferase PagPtarget
Dodecyldimethylamine N-oxideAcyl-CoA thioesterase 2target
Dodecyldimethylamine N-oxideAmine oxidase [flavin-containing] Btarget
Dodecyldimethylamine N-oxideAmine oxidase [flavin-containing] Benzyme
Dodecyldimethylamine N-oxideReaction center protein L chaintarget
Dodecyldimethylamine N-oxideReaction center protein M chaintarget
Dodecyldimethylamine N-oxideReaction center protein H chaintarget
Dodecyldimethylamine N-oxideCytochrome c oxidase subunit 1-betatarget
Dodecyldimethylamine N-oxideCytochrome c oxidase subunit 2target
Dodecyldimethylamine N-oxideIg kappa chain V-I region Bitarget
Dodecyldimethylamine N-oxideIg heavy chain V-III region VH26target
Dodecyldimethylamine N-oxidePhotosynthetic reaction center cytochrome c subunittarget
Dodecyldimethylamine N-oxideReaction center protein H chaintarget
Dodecyldimethylamine N-oxideReaction center protein L chaintarget
Dodecyldimethylamine N-oxideReaction center protein M chaintarget
Dodecyldimethylamine N-oxideH subunit of photosynthetic reaction center complextarget
Dodecyldimethylamine N-oxideDestrintarget
Dodecyldimethylamine N-oxideRhodopsintarget
Dodecyldimethylamine N-oxideCytochrome c2target
Dodecyldimethylamine N-oxideNuclear factor erythroid 2-related factor 1target
Dodecyldimethylamine N-oxideSqualene--hopene cyclasetarget
Dodecyldimethylamine N-oxideVitamin B12 transporter BtuBtarget
Dodecyldimethylamine N-oxideColicin-E3target
Dodecyldimethylamine N-oxideFe(3+)-pyochelin receptortarget
Dodecyldimethylamine N-oxideMyelin P2 proteintarget
Dodecyldimethylamine N-oxideOuter membrane protein Wtarget
Dodecyldimethylamine N-oxideLight-harvesting protein B-800/850 alpha chaintarget
Dodecyldimethylamine N-oxideLight-harvesting protein B-800/850 beta chaintarget
Dodecyldimethylamine N-oxideProtein TonBtarget
Dodecyldimethylamine N-oxideColicin I receptortarget
Dodecyldimethylamine N-oxideColicin-Iatarget
Dodecyldimethylamine N-oxideCofilin-1target
Dodecyldimethylamine N-oxideRhomboid protease GlpGtarget
Dodecyldimethylamine N-oxideOuter membrane protein Gtarget
Dodecyldimethylamine N-oxideOuter membrane usher protein PapCtarget
Dodecyldimethylamine N-oxideProbable N-acetylneuraminic acid outer membrane channel protein NanCtarget
Dodecyldimethylamine N-oxideReaction center protein H chaintarget
Dodecyldimethylamine N-oxideReaction center protein L chaintarget
Dodecyldimethylamine N-oxideReaction center protein M chaintarget
Dodecyldimethylamine N-oxideOuter membrane protein IItarget
Dodecyldimethylamine N-oxideCyclic nucleotide-gated potassium channel mll3241target
Dodecyldimethylamine N-oxideAmmonia channeltarget
Dodecyldimethylamine N-oxidePenicillin-binding protein 2target
Dodecyldimethylamine N-oxideDihydroorotate dehydrogenase (quinone), mitochondrialtarget
Dodecyldimethylamine N-oxideTraO proteintarget
Dodecyldimethylamine N-oxideTraF proteintarget
Dodecyldimethylamine N-oxideTraN proteintarget
Dodecyldimethylamine N-oxideOuter membrane porin, OprD familytarget