Tricarboxylic Acids

Organic compounds that are acyclic and contain three acid groups. A member of this class is citric acid which is the first product formed by reaction of pyruvate and oxaloacetate. (From Lehninger, Principles of Biochemistry, 1982, p443)
DrugDrug NameDrug Indication
DB00201CaffeineFor management of fatigue, orthostatic hypotension, and for the short term treatment of apnea of prematurity in infants.
DB01727Isocitric AcidNot Available
DB04272Citric AcidNot Available
DB09125Potassium CitrateFor the management of renal tubular acidosis, hypocitraturic calcium oxalate nephrolithiasis, and uric acid lithiasis with or without calcium stones.
DB09154Sodium CitrateUsed as an anticoagulant during plasmophoresis as well as a neutralizing agent in the treatment of upset stomach and acidic urine [FDA Label] [L788] [L789].
DB09268Picosulfuric acidIndicated for cleansing of the colon as a preparation for colonoscopy in adults [FDA Label].
DB11093Calcium CitrateFor use as an over the counter calcium supplement.
DB11110Magnesium citrateMagnesium citrate has been used in bowel preparations prior to a colonoscopy as a cathartic agent.[T215] It is also used in over-the-counter products to relieve occasional constipation.[L2841] Magnesium citrate can be one of the forms used for the administration of dietary supplements.[L2842]
DB13076Yttrium Y-90Not Available
DB14507Lithium citrateLithium is used as a mood stabilizer, and is used for treatment of depression and mania. It is often used in bipolar disorder treatment.
DrugDrug NameTargetType
DB00201CaffeineAdenosine receptor A1target
DB00201CaffeinecAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
DB00201CaffeineAdenosine receptor A2atarget
DB00201CaffeineCytochrome P450 1A2enzyme
DB00201CaffeineRyanodine receptor 1target
DB00201CaffeineCytochrome P450 3A4enzyme
DB00201CaffeineCytochrome P450 3A5enzyme
DB00201CaffeineCytochrome P450 3A7enzyme
DB00201CaffeineMultidrug resistance protein 1transporter
DB00201CaffeineCytochrome P450 2E1enzyme
DB00201CaffeineCytochrome P450 2C8enzyme
DB00201CaffeineCytochrome P450 2C9enzyme
DB00201CaffeineCytochrome P450 1A1enzyme
DB00201CaffeineCytochrome P450 1B1enzyme
DB00201CaffeineCytochrome P450 2D6enzyme
DB00201CaffeineCyclic nucleotide phosphodiesterasetarget
DB00201CaffeineDNA-dependent protein kinase catalytic subunittarget
DB00201CaffeinePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformtarget
DB00201CaffeinePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformtarget
DB00201CaffeinePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformtarget
DB00201CaffeineInositol 1,4,5-trisphosphate receptortarget
DB00201CaffeineSerine-protein kinase ATMtarget
DB01727Isocitric AcidIsocitrate dehydrogenase [NADP]target
DB01727Isocitric AcidIsocitrate dehydrogenase [NADP]target
DB01727Isocitric AcidAconitate hydratase, mitochondrialtarget
DB01727Isocitric AcidIsocitrate dehydrogenase [NADP], mitochondrialtarget
DB01727Isocitric AcidIsocitrate dehydrogenase [NADP] cytoplasmictarget
DB01727Isocitric AcidMethylisocitrate lyasetarget
DB04272Citric AcidCell division protein FtsZtarget
DB04272Citric AcidAngiogenintarget
DB04272Citric AcidBeta-lactamase 2target
DB04272Citric AcidUridine-cytidine kinase 2target
DB04272Citric AcidTumor necrosis factor ligand superfamily member 13Btarget
DB04272Citric AcidBetaine--homocysteine S-methyltransferase 1target
DB04272Citric AcidTryptophan--tRNA ligasetarget
DB04272Citric AcidAldose reductasetarget
DB04272Citric AcidCitrate synthase, mitochondrialtarget
DB04272Citric AcidHeparan sulfate glucosamine 3-O-sulfotransferase 3A1target
DB04272Citric AcidcGMP-specific 3',5'-cyclic phosphodiesterasetarget
DB04272Citric AcidProto-oncogene tyrosine-protein kinase Srctarget
DB04272Citric AcidRibonuclease pancreatictarget
DB04272Citric AcidIsocitrate dehydrogenase [NADP]target
DB04272Citric AcidGlycine N-methyltransferasetarget
DB04272Citric AcidEosinophil cationic proteintarget
DB04272Citric AcidBeta-lactamasetarget
DB04272Citric AcidMolybdenum cofactor guanylyltransferasetarget
DB04272Citric AcidFumarate hydratase class IItarget
DB04272Citric Acid6-phosphogluconolactonasetarget
DB04272Citric AcidOxygen-insensitive NAD(P)H nitroreductasetarget
DB04272Citric AcidGag-Pro-Pol polyproteintarget
DB04272Citric AcidL-amino-acid oxidasetarget
DB04272Citric AcidMacrophage migration inhibitory factortarget
DB04272Citric AcidCarboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1target
DB04272Citric Acid1-deoxy-D-xylulose 5-phosphate reductoisomerasetarget
DB04272Citric AcidTryptophan synthase alpha chaintarget
DB04272Citric AcidSialidasetarget
DB04272Citric AcidKHG/KDPG aldolasetarget
DB04272Citric AcidCytochrome c peroxidasetarget
DB04272Citric AcidHepatocyte growth factor-regulated tyrosine kinase substratetarget
DB04272Citric AcidInvasintarget
DB04272Citric AcidIntron-associated endonuclease 1target
DB04272Citric AcidShort tail fiber proteintarget
DB04272Citric AcidMalate dehydrogenase, mitochondrialtarget
DB04272Citric AcidN5-carboxyaminoimidazole ribonucleotide mutasetarget
DB04272Citric Acid50S ribosomal protein L4target
DB04272Citric AcidCarboxypeptidase Btarget
DB04272Citric AcidHexon proteintarget
DB04272Citric AcidRiboflavin biosynthesis protein RibFtarget
DB04272Citric AcidBeta-fructosidasetarget
DB04272Citric AcidPutative stringent starvation protein Atarget
DB04272Citric AcidCitrate synthasetarget
DB04272Citric AcidRNA 3'-terminal phosphate cyclasetarget
DB04272Citric AcidU6 snRNA-associated Sm-like protein LSm6target
DB04272Citric AcidPleckstrin homology domain-containing family A member 1target
DB04272Citric AcidFe(3+)-binding periplasmic proteintarget
DB04272Citric AcidSignal recognition particle receptor FtsYtarget
DB04272Citric AcidNicotinate-nucleotide adenylyltransferasetarget
DB04272Citric AcidN utilization substance protein B homologtarget
DB04272Citric AcidComplement component C8 gamma chaintarget
DB04272Citric AcidRibonucleoside-diphosphate reductase subunit betatarget
DB04272Citric AcidGlutamine synthetase 1target
DB04272Citric AcidCitrate synthasetarget
DB04272Citric AcidProstaglandin F synthasetarget
DB04272Citric AcidAdenine phosphoribosyltransferasetarget
DB04272Citric AcidGlucose-1-phosphate thymidylyltransferasetarget
DB04272Citric AcidGlyoxalase family proteintarget
DB04272Citric AcidLaccase domain protein YfiHtarget
DB04272Citric AcidRibose-5-phosphate isomerase Atarget
DB04272Citric AcidGMP synthase [glutamine-hydrolyzing]target
DB04272Citric AcidInosine triphosphate pyrophosphatasetarget
DB04272Citric AcidLysozymetarget
DB04272Citric AcidGlycerol uptake operon antiterminator regulatory proteintarget
DB04272Citric Acid3-carboxy-cis,cis-muconate cycloisomerasetarget
DB04272Citric AcidPyruvate decarboxylasetarget
DB04272Citric AcidSolute carrier organic anion transporter family member 2B1transporter
DB09154Sodium CitrateMitochondrial 2-oxodicarboxylate carriertransporter
DB09154Sodium CitrateSolute carrier family 13 member 2transporter
DB09154Sodium CitrateSolute carrier family 13 member 5transporter
DB09154Sodium CitrateTricarboxylate transport protein, mitochondrialtransporter
DB09268Picosulfuric acidArylsulfate sulfotransferaseenzyme
DB11093Calcium CitrateTransient receptor potential cation channel subfamily V member 6transporter
DB11093Calcium CitrateCalbindincarrier
DB11093Calcium CitrateProtein S100-Gcarrier
DB11093Calcium CitrateSodium/calcium exchanger 1transporter
DB11093Calcium CitrateTransient receptor potential cation channel subfamily V member 5transporter
DB11093Calcium CitrateExtracellular calcium-sensing receptortarget
DB11093Calcium CitrateCalreticulintarget
DB11093Calcium CitrateCalcium and integrin-binding protein 1target
DB11093Calcium CitrateProgrammed cell death protein 6target
DB11093Calcium CitrateSorcintarget
DB11093Calcium CitrateCalcineurin B homologous protein 1target
DB11093Calcium CitrateSPARCtarget
DB11093Calcium CitrateCalnexintarget
DB11093Calcium CitrateFibrillin-2target
DB11093Calcium CitrateProtein S100-Btarget
DB11093Calcium CitrateCalsequestrin-2target
DB11093Calcium CitrateRegucalcintarget
DB11093Calcium CitratePeflintarget
DB11093Calcium CitrateProtein S100-A6target
DB11093Calcium CitrateTranslationally-controlled tumor proteintarget
DB11093Calcium CitrateCalcium and integrin-binding family member 2target
DB11093Calcium CitrateProtein S100-A13target
DB11093Calcium CitrateCalsequestrin-1target
DB11093Calcium CitrateNucleobindin-1target
DB11093Calcium CitrateNucleobindin-2target
DB11093Calcium CitrateCalmodulintarget
DB11093Calcium CitrateFibrillin-3target
DB11093Calcium CitrateGrancalcintarget
DB11093Calcium CitrateCalcium-dependent secretion activator 1target
DB11093Calcium CitrateSerum albumincarrier
DB11093Calcium CitrateCalmodulin-2target
DB11093Calcium CitrateCalmodulin-3target
DB11093Calcium CitrateProtein S100-A16target
DB11093Calcium CitrateCalretinintarget
DB11093Calcium CitrateCalcyphosintarget
DB11093Calcium CitrateCalcium-dependent secretion activator 2target
DB11093Calcium CitrateCalreticulin-3target
DB11093Calcium CitrateRyanodine receptor 1transporter
DB11093Calcium CitrateRyanodine receptor 2transporter
DB11093Calcium CitratePolycystic kidney disease 2-like 1 proteintransporter
DB11093Calcium CitrateNeurexin-1target
DB11093Calcium CitrateNeuronal calcium sensor 1target
DB11093Calcium CitrateRyanodine receptor 3transporter
DB11093Calcium CitratePolycystic kidney disease protein 1-like 3transporter
DB11093Calcium CitrateCation channel sperm-associated protein 1transporter
DB11093Calcium CitrateVoltage-dependent L-type calcium channeltransporter
DB11093Calcium CitrateVoltage-dependent P/Q-type calcium channeltransporter
DB11093Calcium CitrateVoltage-dependent T-type calcium channeltransporter
DB11093Calcium CitrateVoltage-dependent R-type calcium channeltransporter
DB14507Lithium citrateInositol monophosphatase 2target
DB14507Lithium citrateInositol monophosphatase 1target
DB14507Lithium citrateGlycogen synthase kinase-3 betatarget
DB14507Lithium citrateGlutamate receptor 3target