Tricarboxylic Acids

Name
Tricarboxylic Acids
Accession Number
DBCAT001579
Description

Organic compounds that are acyclic and contain three acid groups. A member of this class is citric acid which is the first product formed by reaction of pyruvate and oxaloacetate. (From Lehninger, Principles of Biochemistry, 1982, p443)

Drugs
DrugDrug Description
CaffeineA stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. It is also used in to prevent and treat pulmonary complications of premature birth.
Isocitric AcidNot Available
Citric acidAn anti-chelation additive used in blood collection tubes and as a flavoring and preservative agent in various cosmetic and pharmaceutical products.
Potassium citrateAn agent used to manage renal tubular acidosis, hypocitraturic calcium oxalate nephrolithiasis, and uric acid lithiasis with or without calcium stones.
Sodium citrateAn ingredient used for the anticoagulation of whole blood as part of automated apheresis procedures.
Picosulfuric acidA stimulant laxative used for cleansing of the colon as a preparation for colonoscopy in adults.
Calcium citrateAn ingredient found in a variety of supplements and vitamins.
Magnesium citrateA laxative used in bowel preparation for colonoscopy or as a magnesium supplement.
Yttrium Y-90Yttrium 90 has been investigated for the treatment of Colon Cancer and Colorectal Cancer.
Lithium citratef
Drugs & Drug Targets
DrugTargetType
CaffeineAdenosine receptor A1target
CaffeinecAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
CaffeineAdenosine receptor A2atarget
CaffeineCytochrome P450 1A2enzyme
CaffeineRyanodine receptor 1target
CaffeineCytochrome P450 3A4enzyme
CaffeineCytochrome P450 2E1enzyme
CaffeineCytochrome P450 2C8enzyme
CaffeineCytochrome P450 2C9enzyme
CaffeineCytochrome P450 1A1enzyme
CaffeineCytochrome P450 1B1enzyme
CaffeineCytochrome P450 2D6enzyme
CaffeineCyclic nucleotide phosphodiesterasetarget
CaffeineDNA-dependent protein kinase catalytic subunittarget
CaffeinePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformtarget
CaffeinePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformtarget
CaffeinePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformtarget
CaffeineInositol 1,4,5-trisphosphate receptortarget
CaffeineSerine-protein kinase ATMtarget
CaffeineATP-binding cassette sub-family G member 2transporter
CaffeineAdenosine receptor A2btarget
CaffeineAdenosine receptor A3target
CaffeinePhosphodiesterase enzymestarget
Isocitric AcidIsocitrate dehydrogenase [NADP]target
Isocitric AcidIsocitrate dehydrogenase [NADP]target
Isocitric AcidAconitate hydratase, mitochondrialtarget
Isocitric AcidIsocitrate dehydrogenase [NADP], mitochondrialtarget
Isocitric AcidIsocitrate dehydrogenase [NADP] cytoplasmictarget
Isocitric AcidMethylisocitrate lyasetarget
Citric acidBeta-lactamase 2target
Citric acidAldose reductasetarget
Citric acidCitrate synthase, mitochondrialtarget
Citric acidProto-oncogene tyrosine-protein kinase Srctarget
Citric acidRibonuclease pancreatictarget
Citric acidIsocitrate dehydrogenase [NADP]target
Citric acidEosinophil cationic proteintarget
Citric acidBeta-lactamasetarget
Citric acidFumarate hydratase class IItarget
Citric acid6-phosphogluconolactonasetarget
Citric acidL-amino-acid oxidasetarget
Citric acidCarboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1target
Citric acidCytochrome c peroxidasetarget
Citric acidHepatocyte growth factor-regulated tyrosine kinase substratetarget
Citric acidInvasintarget
Citric acidIntron-associated endonuclease 1target
Citric acidShort tail fiber proteintarget
Citric acidMalate dehydrogenase, mitochondrialtarget
Citric acidN5-carboxyaminoimidazole ribonucleotide mutasetarget
Citric acid50S ribosomal protein L4target
Citric acidCarboxypeptidase Btarget
Citric acidHexon proteintarget
Citric acidRiboflavin biosynthesis protein RibFtarget
Citric acidBeta-fructosidasetarget
Citric acidPutative stringent starvation protein Atarget
Citric acidCitrate synthasetarget
Citric acidRNA 3'-terminal phosphate cyclasetarget
Citric acidU6 snRNA-associated Sm-like protein LSm6target
Citric acidPleckstrin homology domain-containing family A member 1target
Citric acidFe(3+)-binding periplasmic proteintarget
Citric acidSignal recognition particle receptor FtsYtarget
Citric acidNicotinate-nucleotide adenylyltransferasetarget
Citric acidN utilization substance protein B homologtarget
Citric acidComplement component C8 gamma chaintarget
Citric acidRibonucleoside-diphosphate reductase subunit betatarget
Citric acidGlutamine synthetase 1target
Citric acidCitrate synthasetarget
Citric acidProstaglandin F synthasetarget
Citric acidAdenine phosphoribosyltransferasetarget
Citric acidGlucose-1-phosphate thymidylyltransferasetarget
Citric acidGlyoxalase family proteintarget
Citric acidLaccase domain protein YfiHtarget
Citric acidRibose-5-phosphate isomerase Atarget
Citric acidGMP synthase [glutamine-hydrolyzing]target
Citric acidInosine triphosphate pyrophosphatasetarget
Citric acidLysozymetarget
Citric acidGlycerol uptake operon antiterminator regulatory proteintarget
Citric acid3-carboxy-cis,cis-muconate cycloisomerasetarget
Citric acidPyruvate decarboxylasetarget
Citric acidSolute carrier organic anion transporter family member 2B1transporter
Citric acidMetallo-beta-lactamase type 2target
Sodium citrateMitochondrial 2-oxodicarboxylate carriertransporter
Sodium citrateSolute carrier family 13 member 2transporter
Sodium citrateSolute carrier family 13 member 5transporter
Sodium citrateTricarboxylate transport protein, mitochondrialtransporter
Picosulfuric acidArylsulfate sulfotransferaseenzyme
Calcium citrateTransient receptor potential cation channel subfamily V member 6transporter
Calcium citrateCalbindincarrier
Calcium citrateProtein S100-Gcarrier
Calcium citrateSodium/calcium exchanger 1transporter
Calcium citrateTransient receptor potential cation channel subfamily V member 5transporter
Calcium citrateExtracellular calcium-sensing receptortarget
Calcium citrateCalreticulintarget
Calcium citrateCalcium and integrin-binding protein 1target
Calcium citrateProgrammed cell death protein 6target
Calcium citrateSorcintarget
Calcium citrateCalcineurin B homologous protein 1target
Calcium citrateSPARCtarget
Calcium citrateCalnexintarget
Calcium citrateFibrillin-2target
Calcium citrateProtein S100-Btarget
Calcium citrateCalsequestrin-2target
Calcium citrateRegucalcintarget
Calcium citratePeflintarget
Calcium citrateProtein S100-A6target
Calcium citrateTranslationally-controlled tumor proteintarget
Calcium citrateCalcium and integrin-binding family member 2target
Calcium citrateProtein S100-A13target
Calcium citrateCalsequestrin-1target
Calcium citrateNucleobindin-1target
Calcium citrateNucleobindin-2target
Calcium citrateCalmodulintarget
Calcium citrateFibrillin-3target
Calcium citrateGrancalcintarget
Calcium citrateCalcium-dependent secretion activator 1target
Calcium citrateSerum albumincarrier
Calcium citrateCalmodulin-2target
Calcium citrateCalmodulin-3target
Calcium citrateProtein S100-A16target
Calcium citrateCalretinintarget
Calcium citrateCalcyphosintarget
Calcium citrateCalcium-dependent secretion activator 2target
Calcium citrateCalreticulin-3target
Calcium citrateRyanodine receptor 1transporter
Calcium citrateRyanodine receptor 2transporter
Calcium citratePolycystic kidney disease 2-like 1 proteintransporter
Calcium citrateNeurexin-1target
Calcium citrateNeuronal calcium sensor 1target
Calcium citrateRyanodine receptor 3transporter
Calcium citratePolycystic kidney disease protein 1-like 3transporter
Calcium citrateCation channel sperm-associated protein 1transporter
Calcium citrateVoltage-dependent L-type calcium channeltransporter
Calcium citrateVoltage-dependent P/Q-type calcium channeltransporter
Calcium citrateVoltage-dependent T-type calcium channeltransporter
Calcium citrateVoltage-dependent R-type calcium channeltransporter
Lithium citrateInositol monophosphatase 2target
Lithium citrateInositol monophosphatase 1target
Lithium citrateGlycogen synthase kinase-3 betatarget
Lithium citrateGlutamate receptor 3target