Identification

Name
Sodium Citrate
Accession Number
DB09154  (DB09159)
Type
Small Molecule
Groups
Approved, Investigational
Description

Sodium citrate is the sodium salt of citric acid. It is white, crystalline powder or white, granular crystals, slightly deliquescent in moist air, freely soluble in water, practically insoluble in alcohol. Like citric acid, it has a sour taste. From the medical point of view, it is used as alkalinizing agent. It works by neutralizing excess acid in the blood and urine. It has been indicated for the treatment of metabolic acidosis.

Structure
Thumb
Synonyms
  • Sodium citrate anhydrous
  • Sodium citrate, anhydrous
  • trisodium citrate anhydrous
  • Trisodium citrate, anhydrous
External IDs
E-331(III) / FEMA NO. 3026, ANHYDROUS- / INS NO.331(III) / INS-331(III)
Product Ingredients
IngredientUNIICASInChI Key
Sodium citrate dihydrateB22547B95K6132-04-3NLJMYIDDQXHKNR-UHFFFAOYSA-K
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Anticoagulant Sod Citrate Soltn 4gm/100mlSolution4 gUnknownBaxter Laboratories1990-12-31Not applicableCanada
Anticoagulant Sodium CitrateSolution10 g/250mLIntravenousMedsep Corporation2011-04-15Not applicableUs
Anticoagulant Sodium Citrate 4% W/V Solution, USPSolution4 gUnknownHaemonetics Corporation2012-10-01Not applicableCanada
Anticoagulant Sodium Citrate Sol 4% USPLiquid4 %IntravenousCutter Med & Biol, Division Of Miles Canada Ltd.1988-12-311996-09-09Canada
Anticoagulant Sodium Citrate Solution USPSolution4 gUnknownFenwal, Inc.2011-11-01Not applicableCanada
Haemonetics Anticoagulant Sodium CitrateSolution40 mg/mLExtracorporealHaemonetics Corporation2013-01-10Not applicableUs
IMUFLEX WB-RP Blood Bag System with Integral Whole Blood Leukocyte Reduction Filter (Removing Platelets) with Diversion Blood Sampling Arm Anticoagulant Citrate Phosphate Dextrose (CPD) AND OPTISOL (AS-5) Red Cell PreservativeKitIntravenousTerumo Corporation2010-02-26Not applicableUs
IMUFLEX WB-SP Blood Bag System with Integral Whole Blood Leukocyte Reduction Filter (Saving Platelets) with Diversion Blood Sampling Arm Anticoagulant Citrate Phosphate Dextrose (CPD) AND OPTISOL (AS-5) Red Cell PreservativeKitIntravenousTerumo Corporation2010-12-15Not applicableUs
Leucoflex CGPKitMaco Productions2013-05-31Not applicableUs
MTL1 LeucoflexKitIntravenousMaco Productions2005-11-21Not applicableUs
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Bromo SeltzerPowder3.5 gOralWarner Lambert Canada Inc.1976-12-311999-08-13Canada
Lemon Eno 2650mg/pckPowder2.65 gOralSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.1994-12-311998-08-25Canada
Orange Eno 2645mg/pckPowder2.645 gOralSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.1994-12-311998-08-25Canada
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
A-C-D SolutionSodium Citrate (250 mg) + Citric Acid (80 mg) + Glucose (132 mg)LiquidIntravenousDraximage A Division Of Draxis Specialty Pharmaceuticals Inc1959-12-312003-07-08Canada
Acd ASodium citrate dihydrate (2.2 g/100mL) + Citric acid monohydrate (.8 g/100mL) + Dextrose monohydrate (2.45 g/100mL)Injection, solutionIntravenousTerumo Bct, Ltd.2002-02-25Not applicableUs
Acd ASodium Citrate (2.2 g/100mL) + Citric acid monohydrate (.8 g/100mL) + Glucose (2.45 g/100mL)Injection, solutionIntravenousTerumo Bct2002-02-25Not applicableUs
Acd ASodium citrate dihydrate (2.2 g/100mL) + Citric acid monohydrate (.8 g/100mL) + Dextrose monohydrate (2.45 g/100mL)Injection, solutionIntravenousTerumo Bct, Ltd.2002-02-25Not applicableUs
ACD Blood-Pack Units (PL 146 Plastic)Sodium citrate dihydrate (1.48 g/67.5mL) + Citric Acid (493 mg/67.5mL) + Dextrose monohydrate (1.65 g/67.5mL)SolutionIntravenousFenwal, Inc.2007-03-01Not applicableUs
Acd-ASodium Citrate (2.2 g/100mL) + Citric acid monohydrate (.73 g/100mL) + Glucose (2.45 g/100mL)SolutionIntravenousHaemonetics Corporation1987-11-06Not applicableUs
Acd-ASodium Citrate (22 g/1000mL) + Citric Acid (7.3 g/1000mL) + Dextrose monohydrate (24.5 g/1000mL)SolutionIntravenousFenwal, Inc.2007-03-01Not applicableUs
Acd-ASodium Citrate (2.2 g/100mL) + Citric Acid (730 mg/100mL) + Dextrose monohydrate (2.45 g/100mL)SolutionIntravenousFenwal, Inc.2012-10-24Not applicableUs
Additive Solution Formula 3 As-3Sodium citrate dihydrate (0.588 g) + Adenine (0.030 g) + Citric acid monohydrate (0.042 g) + Glucose (1.10 g) + Sodium Chloride (0.410 g) + Sodium phosphate, monobasic, monohydrate (0.276 g)SolutionUnknownTerumo Bct, Inc.2013-05-31Not applicableCanada
ADSOL Red Cell Preservation Solution System in Plastic Container (PL 146 Plastic)Sodium citrate dihydrate (1.84 g/70mL) + Adenine (30 mg/110mL) + Citric Acid (209 mg/70mL) + Dextrose monohydrate (1.78 g/70mL) + Dextrose monohydrate (2.42 g/110mL) + Mannitol (825 mg/110mL) + Sodium Chloride (990 mg/110mL) + Sodium phosphate, monobasic, monohydrate (155 mg/70mL)KitFenwal, Inc.2007-03-01Not applicableUs
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
EnLyteSodium Citrate (3.67 mg/1) + 1,2-docosahexanoyl-sn-glycero-3-phosphoserine calcium (6.4 mg/1) + 1,2-icosapentoyl-sn-glycero-3-phosphoserine calcium (800 ug/1) + Citric acid monohydrate (1.83 mg/1) + Cobamamide (50 ug/1) + Cocarboxylase (25 ug/1) + Ferrous cysteine glycinate (13.6 mg/1) + Flavin adenine dinucleotide (25 ug/1) + Folic Acid (1 mg/1) + Glycine betaine (500 ug/1) + Leucovorin (2.5 mg/1) + Levomefolate magnesium (7 mg/1) + NADH (25 ug/1) + Phosphatidyl serine (12 mg/1) + Pyridoxal Phosphate (25 ug/1) + Magnesium L-threonate (1 mg/1) + Magnesium ascorbate (24 mg/1) + Zinc ascorbate (1 mg/1)Capsule, delayed release pelletsOralJaymac Pharmaceuticals Llc2011-10-01Not applicableUs
NauzeneSodium citrate dihydrate (230 mg/1)Tablet, chewableOralAlva Amco Pharmacal Companies, Inc.2000-07-08Not applicableUs
OracitSodium citrate dihydrate (640 mg/5mL) + Citric acid monohydrate (490 mg/5mL)LiquidOralCardinal Health2011-06-072018-05-11Us
OracitSodium citrate dihydrate (490 mg/5mL) + Citric acid monohydrate (640 mg/5mL)SolutionOralCmp Pharma, Inc.1984-05-15Not applicableUs
Potassium Citrate-Sodium Citrate-Citric AcidSodium citrate dihydrate (500 mg/5mL) + Citric acid monohydrate (334 mg/5mL) + Potassium Citrate (550 mg/5mL)SolutionOralMethod Pharmaceuticals2014-10-202015-12-31Us
Potassium Citrate-Sodium Citrate-Citric AcidSodium citrate dihydrate (500 mg/5mL) + Citric acid monohydrate (334 mg/5mL) + Potassium Citrate (550 mg/5mL)SolutionOralMethod Pharmaceuticals2015-12-212016-03-05Us
Sodium Citrate and Citric AcidSodium Citrate (500 mg/5mL) + Citric Acid (334 mg/5mL)SolutionOralPharmaceutical Associates, Inc.1969-01-01Not applicableUs
Sodium Citrate and Citric AcidSodium Citrate (500 mg/5mL) + Citric Acid (334 mg/5mL)SolutionOralPharmaceutical Associates, Inc.1969-01-01Not applicableUs
Sodium Citrate and Citric AcidSodium Citrate (500 mg/5mL) + Citric Acid (334 mg/5mL)SolutionOralAtlantic Biologicals Corps.1969-01-01Not applicableUs
Sodium Citrate-Citric AcidSodium citrate dihydrate (500 mg/5mL) + Citric acid monohydrate (334 mg/5mL)SolutionOralMethod Pharmaceuticals2014-10-202015-12-31Us
Categories
UNII
RS7A450LGA
CAS number
68-04-2
Weight
Average: 258.068
Monoisotopic: 257.97283534
Chemical Formula
C6H5Na3O7
InChI Key
HRXKRNGNAMMEHJ-UHFFFAOYSA-K
InChI
InChI=1S/C6H8O7.3Na/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;/q;3*+1/p-3
IUPAC Name
trisodium 2-hydroxypropane-1,2,3-tricarboxylate
SMILES
[Na+].[Na+].[Na+].OC(CC([O-])=O)(CC([O-])=O)C([O-])=O

Pharmacology

Indication

Used as an anticoagulant during plasmophoresis as well as a neutralizing agent in the treatment of upset stomach and acidic urine [FDA Label] [6] [7].

Associated Conditions
Associated Therapies
Pharmacodynamics

Citrate prevents activation of the clotting cascade by chelating calcium ions. Citrate neutralizes acid in the stomach and urine, raising the pH [8].

Mechanism of action

Citrate chelates free calcium ions preventing them from forming a complex with tissue factor and coagulation factor VIIa to promote the activation of coagulation factor X [1] [2]. This inhibits the extrinsic initiation of the coagulation cascade. Citrate may also exert an anticoagulant effect via a so far unknown mechanism as restoration of calcium concentration does not fully reverse the effect of citrate [1]. Citrate is a weak base and so reacts with hydrochloric acid in the stomach to raise the pH. It it further metabolized to bicarbonate which then acts as a systemic alkalizing agent, raising the pH of the blood and urine [8]. It also acts as a diuretic and increases the urinary excretion of calcium.

Absorption

Tmax of 98-130min [3].

Volume of distribution

19-39L [3].

Protein binding
Not Available
Metabolism

Citrate is metabolized to bicarbonate in the liver and plays a role as an intermediate in the citric acid cycle [5] [9].

Route of elimination

Largely eliminated through hepatic metabolism with very little cleared by the kidneys [3] [4].

Half life

18-54 min [3]

Clearance

Total clearance of 313-1107mL/min [3].

Toxicity

Overdose toxicity is mainly due to alkalosis as well as tetany or depressed heart function due to lack of free calcium [8].

Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
(4R)-limonene(4R)-limonene may increase the anticoagulant activities of Sodium Citrate.Investigational
AbciximabAbciximab may increase the anticoagulant activities of Sodium Citrate.Approved
AceclofenacAceclofenac may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
AcemetacinThe risk or severity of bleeding can be increased when Sodium Citrate is combined with Acemetacin.Approved, Experimental, Investigational
AcenocoumarolAcenocoumarol may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
Acetylsalicylic acidAcetylsalicylic acid may increase the anticoagulant activities of Sodium Citrate.Approved, Vet Approved
AdapaleneAdapalene may increase the anticoagulant activities of Sodium Citrate.Approved
AlclofenacAlclofenac may increase the anticoagulant activities of Sodium Citrate.Approved, Withdrawn
AllylestrenolThe therapeutic efficacy of Sodium Citrate can be decreased when used in combination with Allylestrenol.Approved
AlminoprofenAlminoprofen may increase the anticoagulant activities of Sodium Citrate.Experimental
AloxiprinAloxiprin may increase the anticoagulant activities of Sodium Citrate.Experimental
AlprostadilAlprostadil may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
AlteplaseAlteplase may increase the anticoagulant activities of Sodium Citrate.Approved
AltrenogestThe therapeutic efficacy of Sodium Citrate can be decreased when used in combination with Altrenogest.Vet Approved
Aluminum hydroxideSodium Citrate can cause an increase in the absorption of Aluminum hydroxide resulting in an increased serum concentration and potentially a worsening of adverse effects.Approved, Investigational
Aminosalicylic AcidAminosalicylic Acid may increase the anticoagulant activities of Sodium Citrate.Approved
AnagrelideAnagrelide may increase the anticoagulant activities of Sodium Citrate.Approved
AncrodAncrod may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
AndrographolideAndrographolide may increase the anticoagulant activities of Sodium Citrate.Investigational
AnisodamineAnisodamine may increase the anticoagulant activities of Sodium Citrate.Investigational
AnistreplaseAnistreplase may increase the anticoagulant activities of Sodium Citrate.Approved
AntipyrineAntipyrine may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
Antithrombin III humanAntithrombin III human may increase the anticoagulant activities of Sodium Citrate.Approved
ApixabanApixaban may increase the anticoagulant activities of Sodium Citrate.Approved
ApocyninApocynin may increase the anticoagulant activities of Sodium Citrate.Investigational
ApremilastApremilast may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
ArdeparinArdeparin may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational, Withdrawn
ArgatrobanArgatroban may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
AstaxanthinAstaxanthin may increase the anticoagulant activities of Sodium Citrate.Investigational
AzapropazoneAzapropazone may increase the anticoagulant activities of Sodium Citrate.Withdrawn
AzelastineAzelastine may increase the anticoagulant activities of Sodium Citrate.Approved
Azficel-TThe risk or severity of adverse effects can be increased when Sodium Citrate is combined with Azficel-T.Approved, Investigational
BalsalazideBalsalazide may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
BatroxobinBatroxobin may increase the anticoagulant activities of Sodium Citrate.Experimental
BazedoxifeneBazedoxifene may decrease the anticoagulant activities of Sodium Citrate.Approved, Investigational
BecaplerminBecaplermin may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
BemiparinBemiparin may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
BendazacBendazac may increase the anticoagulant activities of Sodium Citrate.Experimental
BenorilateBenorilate may increase the anticoagulant activities of Sodium Citrate.Experimental
BenoxaprofenBenoxaprofen may increase the anticoagulant activities of Sodium Citrate.Withdrawn
BenzydamineBenzydamine may increase the anticoagulant activities of Sodium Citrate.Approved
BeraprostBeraprost may increase the anticoagulant activities of Sodium Citrate.Investigational
BetrixabanThe risk or severity of bleeding can be increased when Betrixaban is combined with Sodium Citrate.Approved, Investigational
BevoniumBevonium may increase the anticoagulant activities of Sodium Citrate.Experimental
BivalirudinBivalirudin may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
BrinaseBrinase may increase the anticoagulant activities of Sodium Citrate.Experimental
BromfenacBromfenac may increase the anticoagulant activities of Sodium Citrate.Approved
BucillamineBucillamine may increase the anticoagulant activities of Sodium Citrate.Investigational
BufexamacBufexamac may increase the anticoagulant activities of Sodium Citrate.Approved, Experimental
BuflomedilBuflomedil may increase the anticoagulant activities of Sodium Citrate.Experimental
BumadizoneBumadizone may increase the anticoagulant activities of Sodium Citrate.Experimental
ButylphthalideButylphthalide may increase the anticoagulant activities of Sodium Citrate.Investigational
CangrelorCangrelor may increase the anticoagulant activities of Sodium Citrate.Approved
CaplacizumabCaplacizumab may increase the anticoagulant activities of Sodium Citrate.Investigational
Carbaspirin calciumCarbaspirin calcium may increase the anticoagulant activities of Sodium Citrate.Experimental, Investigational
CarprofenCarprofen may increase the anticoagulant activities of Sodium Citrate.Approved, Vet Approved, Withdrawn
CastanospermineCastanospermine may increase the anticoagulant activities of Sodium Citrate.Experimental
CelecoxibCelecoxib may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
CertoparinCertoparin may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
ChlormadinoneThe therapeutic efficacy of Sodium Citrate can be decreased when used in combination with Chlormadinone.Experimental
ChloroquineChloroquine may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational, Vet Approved
ChlorotrianiseneChlorotrianisene may decrease the anticoagulant activities of Sodium Citrate.Investigational, Withdrawn
Choline magnesium trisalicylateCholine magnesium trisalicylate may increase the anticoagulant activities of Sodium Citrate.Approved
CilostazolCilostazol may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
Citric AcidCitric Acid may increase the anticoagulant activities of Sodium Citrate.Approved, Nutraceutical, Vet Approved
ClonixinClonixin may increase the anticoagulant activities of Sodium Citrate.Approved
ClopidogrelClopidogrel may increase the anticoagulant activities of Sodium Citrate.Approved
CloricromenCloricromen may increase the anticoagulant activities of Sodium Citrate.Experimental
ClorindioneClorindione may increase the anticoagulant activities of Sodium Citrate.Experimental
Collagenase clostridium histolyticumThe risk or severity of adverse effects can be increased when Sodium Citrate is combined with Collagenase clostridium histolyticum.Approved, Investigational
Conjugated estrogensConjugated estrogens may decrease the anticoagulant activities of Sodium Citrate.Approved
CurcuminCurcumin may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
Dabigatran etexilateDabigatran etexilate may increase the anticoagulant activities of Sodium Citrate.Approved
DaidzeinDaidzein may decrease the anticoagulant activities of Sodium Citrate.Experimental
DalteparinDalteparin may increase the anticoagulant activities of Sodium Citrate.Approved
DanaparoidDanaparoid may increase the anticoagulant activities of Sodium Citrate.Approved, Withdrawn
DarexabanDarexaban may increase the anticoagulant activities of Sodium Citrate.Investigational
DasatinibDasatinib may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
DeferasiroxThe risk or severity of adverse effects can be increased when Sodium Citrate is combined with Deferasirox.Approved, Investigational
DefibrotideDefibrotide may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
DemegestoneThe therapeutic efficacy of Sodium Citrate can be decreased when used in combination with Demegestone.Approved
Deoxycholic AcidThe risk or severity of adverse effects can be increased when Sodium Citrate is combined with Deoxycholic Acid.Approved
DersalazineDersalazine may increase the anticoagulant activities of Sodium Citrate.Investigational
DesirudinDesirudin may increase the anticoagulant activities of Sodium Citrate.Approved
DesmoteplaseDesmoteplase may increase the anticoagulant activities of Sodium Citrate.Investigational
DesogestrelThe therapeutic efficacy of Sodium Citrate can be decreased when used in combination with Desogestrel.Approved
DextranDextran may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational, Vet Approved
DiclofenacDiclofenac may increase the anticoagulant activities of Sodium Citrate.Approved, Vet Approved
DicoumarolDicoumarol may increase the anticoagulant activities of Sodium Citrate.Approved
DienestrolDienestrol may decrease the anticoagulant activities of Sodium Citrate.Approved, Investigational
DienogestThe therapeutic efficacy of Sodium Citrate can be decreased when used in combination with Dienogest.Approved
DiethylstilbestrolDiethylstilbestrol may decrease the anticoagulant activities of Sodium Citrate.Approved, Investigational
DifenpiramideDifenpiramide may increase the anticoagulant activities of Sodium Citrate.Experimental
DiflunisalDiflunisal may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
DiphenadioneDiphenadione may increase the anticoagulant activities of Sodium Citrate.Experimental
DipyridamoleDipyridamole may increase the anticoagulant activities of Sodium Citrate.Approved
DitazoleDitazole may increase the anticoagulant activities of Sodium Citrate.Approved, Withdrawn
DrospirenoneThe therapeutic efficacy of Sodium Citrate can be decreased when used in combination with Drospirenone.Approved
Drotrecogin alfaDrotrecogin alfa may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational, Withdrawn
DroxicamDroxicam may increase the anticoagulant activities of Sodium Citrate.Withdrawn
DuvelisibDuvelisib may increase the anticoagulant activities of Sodium Citrate.Investigational
DydrogesteroneThe therapeutic efficacy of Sodium Citrate can be decreased when used in combination with Dydrogesterone.Approved, Investigational, Withdrawn
E-6201E-6201 may increase the anticoagulant activities of Sodium Citrate.Investigational
Edetic AcidEdetic Acid may increase the anticoagulant activities of Sodium Citrate.Approved, Vet Approved
EdoxabanEdoxaban may increase the anticoagulant activities of Sodium Citrate.Approved
EnoxaparinEnoxaparin may increase the anticoagulant activities of Sodium Citrate.Approved
EpimestrolEpimestrol may decrease the anticoagulant activities of Sodium Citrate.Experimental
EpinastineEpinastine may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
EpirizoleEpirizole may increase the anticoagulant activities of Sodium Citrate.Approved
EplivanserinEplivanserin may increase the anticoagulant activities of Sodium Citrate.Investigational
eplivanserineeplivanserine may increase the anticoagulant activities of Sodium Citrate.Investigational
EpoprostenolEpoprostenol may increase the anticoagulant activities of Sodium Citrate.Approved
EptifibatideEptifibatide may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
EquolEquol may decrease the anticoagulant activities of Sodium Citrate.Investigational
EstradiolEstradiol may decrease the anticoagulant activities of Sodium Citrate.Approved, Investigational, Vet Approved
Estradiol acetateEstradiol acetate may decrease the anticoagulant activities of Sodium Citrate.Approved, Investigational, Vet Approved
Estradiol cypionateEstradiol cypionate may decrease the anticoagulant activities of Sodium Citrate.Approved, Investigational, Vet Approved
Estradiol valerateEstradiol valerate may decrease the anticoagulant activities of Sodium Citrate.Approved, Investigational, Vet Approved
EstriolEstriol may decrease the anticoagulant activities of Sodium Citrate.Approved, Investigational, Vet Approved
Estrogens, esterifiedEstrogens, esterified may decrease the anticoagulant activities of Sodium Citrate.Approved
EstroneEstrone may decrease the anticoagulant activities of Sodium Citrate.Approved
EtanerceptEtanercept may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
EthenzamideEthenzamide may increase the anticoagulant activities of Sodium Citrate.Experimental
Ethinyl EstradiolEthinyl Estradiol may decrease the anticoagulant activities of Sodium Citrate.Approved
Ethyl biscoumacetateEthyl biscoumacetate may increase the anticoagulant activities of Sodium Citrate.Withdrawn
EthynodiolThe therapeutic efficacy of Sodium Citrate can be decreased when used in combination with Ethynodiol.Experimental
EtodolacEtodolac may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational, Vet Approved
EtofenamateEtofenamate may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
EtonogestrelThe therapeutic efficacy of Sodium Citrate can be decreased when used in combination with Etonogestrel.Approved, Investigational
EtoricoxibEtoricoxib may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
Evening primrose oilEvening primrose oil may increase the anticoagulant activities of Sodium Citrate.Investigational, Nutraceutical
ExisulindExisulind may increase the anticoagulant activities of Sodium Citrate.Investigational
FelbinacFelbinac may increase the anticoagulant activities of Sodium Citrate.Experimental
FenbufenFenbufen may increase the anticoagulant activities of Sodium Citrate.Approved
FenoprofenFenoprofen may increase the anticoagulant activities of Sodium Citrate.Approved
FentiazacFentiazac may increase the anticoagulant activities of Sodium Citrate.Experimental
FeprazoneFeprazone may increase the anticoagulant activities of Sodium Citrate.Experimental
Ferulic acidFerulic acid may increase the anticoagulant activities of Sodium Citrate.Experimental
FibrinolysinFibrinolysin may increase the anticoagulant activities of Sodium Citrate.Investigational
FloctafenineFloctafenine may increase the anticoagulant activities of Sodium Citrate.Approved, Withdrawn
FluindioneFluindione may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
FlunixinFlunixin may increase the anticoagulant activities of Sodium Citrate.Vet Approved
FlunoxaprofenFlunoxaprofen may increase the anticoagulant activities of Sodium Citrate.Experimental
FlurbiprofenFlurbiprofen may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
FondaparinuxFondaparinux may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
Fondaparinux sodiumFondaparinux sodium may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
GabexateGabexate may increase the anticoagulant activities of Sodium Citrate.Investigational
GenisteinGenistein may decrease the anticoagulant activities of Sodium Citrate.Investigational
GestodeneThe therapeutic efficacy of Sodium Citrate can be decreased when used in combination with Gestodene.Approved, Investigational
GestonoroneThe therapeutic efficacy of Sodium Citrate can be decreased when used in combination with Gestonorone.Experimental
GestrinoneThe therapeutic efficacy of Sodium Citrate can be decreased when used in combination with Gestrinone.Approved
GuacetisalGuacetisal may increase the anticoagulant activities of Sodium Citrate.Experimental
HeminHemin may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
Hemoglobin crosfumarilHemoglobin crosfumaril may increase the anticoagulant activities of Sodium Citrate.Experimental
HeparinHeparin may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
HexestrolHexestrol may decrease the anticoagulant activities of Sodium Citrate.Withdrawn
HigenamineHigenamine may increase the anticoagulant activities of Sodium Citrate.Investigational
Hydroxyprogesterone caproateThe therapeutic efficacy of Sodium Citrate can be decreased when used in combination with Hydroxyprogesterone caproate.Approved, Investigational
HydroxytyrosolHydroxytyrosol may increase the anticoagulant activities of Sodium Citrate.Investigational
Ibritumomab tiuxetanThe risk or severity of adverse effects can be increased when Sodium Citrate is combined with Ibritumomab tiuxetan.Approved, Investigational
IbrutinibThe risk or severity of adverse effects can be increased when Ibrutinib is combined with Sodium Citrate.Approved
IbudilastIbudilast may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
IbuprofenIbuprofen may increase the anticoagulant activities of Sodium Citrate.Approved
IbuproxamIbuproxam may increase the anticoagulant activities of Sodium Citrate.Withdrawn
IcatibantIcatibant may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
Icosapent ethylIcosapent ethyl may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational, Nutraceutical
IdraparinuxIdraparinux may increase the anticoagulant activities of Sodium Citrate.Investigational
IfenprodilIfenprodil may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational, Withdrawn
IfetrobanIfetroban may increase the anticoagulant activities of Sodium Citrate.Investigational
IloprostIloprost may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
Imidazole salicylateImidazole salicylate may increase the anticoagulant activities of Sodium Citrate.Experimental
IndobufenIndobufen may increase the anticoagulant activities of Sodium Citrate.Investigational
IndomethacinIndomethacin may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
IndoprofenIndoprofen may increase the anticoagulant activities of Sodium Citrate.Withdrawn
IsoxicamIsoxicam may increase the anticoagulant activities of Sodium Citrate.Withdrawn
KebuzoneKebuzone may increase the anticoagulant activities of Sodium Citrate.Experimental
KetanserinKetanserin may increase the anticoagulant activities of Sodium Citrate.Investigational
KetoprofenKetoprofen may increase the anticoagulant activities of Sodium Citrate.Approved, Vet Approved
KetorolacKetorolac may increase the anticoagulant activities of Sodium Citrate.Approved
LeflunomideLeflunomide may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
LepirudinSodium Citrate may increase the anticoagulant activities of Lepirudin.Approved
LetaxabanLetaxaban may increase the anticoagulant activities of Sodium Citrate.Investigational
LevonorgestrelThe therapeutic efficacy of Sodium Citrate can be decreased when used in combination with Levonorgestrel.Approved, Investigational
LimaprostThe risk or severity of adverse effects can be increased when Limaprost is combined with Sodium Citrate.Approved, Investigational
LinsidomineLinsidomine may increase the anticoagulant activities of Sodium Citrate.Experimental
LisofyllineLisofylline may increase the anticoagulant activities of Sodium Citrate.Investigational
LonazolacLonazolac may increase the anticoagulant activities of Sodium Citrate.Experimental
LornoxicamLornoxicam may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
LoxoprofenLoxoprofen may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
LumiracoxibLumiracoxib may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
LynestrenolThe therapeutic efficacy of Sodium Citrate can be decreased when used in combination with Lynestrenol.Approved, Investigational
Magnesium salicylateMagnesium salicylate may increase the anticoagulant activities of Sodium Citrate.Approved
MasoprocolMasoprocol may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
Meclofenamic acidMeclofenamic acid may increase the anticoagulant activities of Sodium Citrate.Approved, Vet Approved
MedrogestoneThe therapeutic efficacy of Sodium Citrate can be decreased when used in combination with Medrogestone.Approved
Medroxyprogesterone acetateThe therapeutic efficacy of Sodium Citrate can be decreased when used in combination with Medroxyprogesterone acetate.Approved, Investigational
Mefenamic acidMefenamic acid may increase the anticoagulant activities of Sodium Citrate.Approved
Megestrol acetateThe therapeutic efficacy of Sodium Citrate can be decreased when used in combination with Megestrol acetate.Approved, Investigational, Vet Approved
MelagatranMelagatran may increase the anticoagulant activities of Sodium Citrate.Experimental
MeloxicamMeloxicam may increase the anticoagulant activities of Sodium Citrate.Approved, Vet Approved
MesalazineMesalazine may increase the anticoagulant activities of Sodium Citrate.Approved
MestranolMestranol may decrease the anticoagulant activities of Sodium Citrate.Approved
MetamizoleMetamizole may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational, Withdrawn
MethallenestrilMethallenestril may decrease the anticoagulant activities of Sodium Citrate.Experimental
Methyl salicylateMethyl salicylate may increase the anticoagulant activities of Sodium Citrate.Approved, Vet Approved
MethylestrenoloneThe therapeutic efficacy of Sodium Citrate can be decreased when used in combination with Methylestrenolone.Experimental
MilrinoneMilrinone may increase the anticoagulant activities of Sodium Citrate.Approved
MizoribineMizoribine may increase the anticoagulant activities of Sodium Citrate.Investigational
MofebutazoneMofebutazone may increase the anticoagulant activities of Sodium Citrate.Experimental
MoxestrolMoxestrol may decrease the anticoagulant activities of Sodium Citrate.Experimental
Mycophenolate mofetilMycophenolate mofetil may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
Mycophenolic acidMycophenolic acid may increase the anticoagulant activities of Sodium Citrate.Approved
NabumetoneNabumetone may increase the anticoagulant activities of Sodium Citrate.Approved
NadroparinNadroparin may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
NafamostatNafamostat may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
NaftifineNaftifine may increase the anticoagulant activities of Sodium Citrate.Approved
NaftopidilNaftopidil may increase the anticoagulant activities of Sodium Citrate.Investigational
NaproxenNaproxen may increase the anticoagulant activities of Sodium Citrate.Approved, Vet Approved
NepafenacNepafenac may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
NifenazoneNifenazone may increase the anticoagulant activities of Sodium Citrate.Experimental
Niflumic AcidNiflumic Acid may increase the anticoagulant activities of Sodium Citrate.Approved
NimesulideNimesulide may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational, Withdrawn
NintedanibThe risk or severity of adverse effects can be increased when Sodium Citrate is combined with Nintedanib.Approved
NitroaspirinNitroaspirin may increase the anticoagulant activities of Sodium Citrate.Investigational
NomegestrolThe therapeutic efficacy of Sodium Citrate can be decreased when used in combination with Nomegestrol.Approved
NorethisteroneThe therapeutic efficacy of Sodium Citrate can be decreased when used in combination with Norethisterone.Approved
NorgestrienoneThe therapeutic efficacy of Sodium Citrate can be decreased when used in combination with Norgestrienone.Experimental
ObinutuzumabThe risk or severity of adverse effects can be increased when Sodium Citrate is combined with Obinutuzumab.Approved, Investigational
OlopatadineOlopatadine may increase the anticoagulant activities of Sodium Citrate.Approved
OlsalazineOlsalazine may increase the anticoagulant activities of Sodium Citrate.Approved
Omacetaxine mepesuccinateThe risk or severity of bleeding can be increased when Sodium Citrate is combined with Omacetaxine mepesuccinate.Approved, Investigational
Omega-3 fatty acidsOmega-3 fatty acids may increase the anticoagulant activities of Sodium Citrate.Approved, Nutraceutical
Omega-3-carboxylic acidsThe therapeutic efficacy of Sodium Citrate can be increased when used in combination with Omega-3-carboxylic acids.Approved, Investigational
OrgoteinOrgotein may increase the anticoagulant activities of Sodium Citrate.Vet Approved
OtamixabanOtamixaban may increase the anticoagulant activities of Sodium Citrate.Investigational
OxaprozinOxaprozin may increase the anticoagulant activities of Sodium Citrate.Approved
OxyphenbutazoneOxyphenbutazone may increase the anticoagulant activities of Sodium Citrate.Approved, Withdrawn
OzagrelOzagrel may increase the anticoagulant activities of Sodium Citrate.Investigational
PalmidrolPalmidrol may increase the anticoagulant activities of Sodium Citrate.Experimental, Nutraceutical
ParecoxibParecoxib may increase the anticoagulant activities of Sodium Citrate.Approved
ParnaparinParnaparin may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
ParthenolideParthenolide may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
Pentaerythritol TetranitratePentaerythritol Tetranitrate may increase the anticoagulant activities of Sodium Citrate.Approved
Pentosan PolysulfatePentosan Polysulfate may increase the anticoagulant activities of Sodium Citrate.Approved
PentoxifyllinePentoxifylline may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
PhenindionePhenindione may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
PhenprocoumonPhenprocoumon may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
Phenyl aminosalicylatePhenyl aminosalicylate may increase the anticoagulant activities of Sodium Citrate.Approved
PhenylbutazonePhenylbutazone may increase the anticoagulant activities of Sodium Citrate.Approved, Vet Approved
PicotamidePicotamide may increase the anticoagulant activities of Sodium Citrate.Experimental
PimecrolimusPimecrolimus may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
PirfenidonePirfenidone may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
PiroxicamPiroxicam may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
PirprofenPirprofen may increase the anticoagulant activities of Sodium Citrate.Experimental
Polyestradiol phosphatePolyestradiol phosphate may decrease the anticoagulant activities of Sodium Citrate.Approved
Potassium CitratePotassium Citrate may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational, Vet Approved
PranoprofenPranoprofen may increase the anticoagulant activities of Sodium Citrate.Experimental, Investigational
PrasugrelPrasugrel may increase the anticoagulant activities of Sodium Citrate.Approved
ProgesteroneThe therapeutic efficacy of Sodium Citrate can be decreased when used in combination with Progesterone.Approved, Vet Approved
ProglumetacinProglumetacin may increase the anticoagulant activities of Sodium Citrate.Experimental
PromegestoneThe therapeutic efficacy of Sodium Citrate can be decreased when used in combination with Promegestone.Experimental
PromestrienePromestriene may decrease the anticoagulant activities of Sodium Citrate.Investigational
PropacetamolPropacetamol may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
PropyphenazonePropyphenazone may increase the anticoagulant activities of Sodium Citrate.Experimental
ProquazoneProquazone may increase the anticoagulant activities of Sodium Citrate.Experimental
Protein CProtein C may increase the anticoagulant activities of Sodium Citrate.Approved
Protein S humanProtein S human may increase the anticoagulant activities of Sodium Citrate.Approved
ProtocatechualdehydeProtocatechualdehyde may increase the anticoagulant activities of Sodium Citrate.Approved
PTC299PTC299 may increase the anticoagulant activities of Sodium Citrate.Investigational
QuinestrolQuinestrol may decrease the anticoagulant activities of Sodium Citrate.Approved
QuingestanolThe therapeutic efficacy of Sodium Citrate can be decreased when used in combination with Quingestanol.Experimental
RamatrobanRamatroban may increase the anticoagulant activities of Sodium Citrate.Investigational
RelcovaptanRelcovaptan may increase the anticoagulant activities of Sodium Citrate.Investigational
ResveratrolResveratrol may increase the anticoagulant activities of Sodium Citrate.Approved, Experimental, Investigational
ReteplaseReteplase may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
ReviparinReviparin may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
RidogrelRidogrel may increase the anticoagulant activities of Sodium Citrate.Approved
RivaroxabanSodium Citrate may increase the anticoagulant activities of Rivaroxaban.Approved
RofecoxibRofecoxib may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational, Withdrawn
RosiglitazoneRosiglitazone may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
SalicylamideSalicylamide may increase the anticoagulant activities of Sodium Citrate.Approved
Salicylic acidSalicylic acid may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational, Vet Approved
SalsalateSalsalate may increase the anticoagulant activities of Sodium Citrate.Approved
SarpogrelateSarpogrelate may increase the anticoagulant activities of Sodium Citrate.Investigational
SaruplaseSaruplase may increase the anticoagulant activities of Sodium Citrate.Experimental
SecoisolariciresinolSecoisolariciresinol may decrease the anticoagulant activities of Sodium Citrate.Investigational
SelexipagSelexipag may increase the anticoagulant activities of Sodium Citrate.Approved
SemapimodSemapimod may increase the anticoagulant activities of Sodium Citrate.Investigational
SeratrodastSeratrodast may increase the anticoagulant activities of Sodium Citrate.Approved
SerrapeptaseSerrapeptase may increase the anticoagulant activities of Sodium Citrate.Investigational
SevofluraneSevoflurane may increase the anticoagulant activities of Sodium Citrate.Approved, Vet Approved
SRT501SRT501 may increase the anticoagulant activities of Sodium Citrate.Investigational
StreptokinaseStreptokinase may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
SugammadexSugammadex may increase the anticoagulant activities of Sodium Citrate.Approved
SulfasalazineSulfasalazine may increase the anticoagulant activities of Sodium Citrate.Approved
SulindacSulindac may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
SulodexideSulodexide may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
SuprofenSuprofen may increase the anticoagulant activities of Sodium Citrate.Approved, Withdrawn
SuxibuzoneSuxibuzone may increase the anticoagulant activities of Sodium Citrate.Experimental
Synthetic Conjugated Estrogens, ASynthetic Conjugated Estrogens, A may decrease the anticoagulant activities of Sodium Citrate.Approved
Synthetic Conjugated Estrogens, BSynthetic Conjugated Estrogens, B may decrease the anticoagulant activities of Sodium Citrate.Approved
TarenflurbilTarenflurbil may increase the anticoagulant activities of Sodium Citrate.Investigational
TenecteplaseTenecteplase may increase the anticoagulant activities of Sodium Citrate.Approved
TenidapTenidap may increase the anticoagulant activities of Sodium Citrate.Experimental
TenoxicamTenoxicam may increase the anticoagulant activities of Sodium Citrate.Approved
TepoxalinTepoxalin may increase the anticoagulant activities of Sodium Citrate.Vet Approved
TeriflunomideTeriflunomide may increase the anticoagulant activities of Sodium Citrate.Approved
TesmilifeneTesmilifene may increase the anticoagulant activities of Sodium Citrate.Investigational
Testosterone cypionateThe therapeutic efficacy of Sodium Citrate can be increased when used in combination with Testosterone cypionate.Approved
Testosterone enanthateThe therapeutic efficacy of Sodium Citrate can be increased when used in combination with Testosterone enanthate.Approved
Testosterone undecanoateThe therapeutic efficacy of Sodium Citrate can be increased when used in combination with Testosterone undecanoate.Approved, Investigational
Tiaprofenic acidTiaprofenic acid may increase the anticoagulant activities of Sodium Citrate.Approved
TiboloneTibolone may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
TicagrelorTicagrelor may increase the anticoagulant activities of Sodium Citrate.Approved
TiclopidineTiclopidine may increase the anticoagulant activities of Sodium Citrate.Approved
TinoridineTinoridine may increase the anticoagulant activities of Sodium Citrate.Investigational
TinzaparinTinzaparin may increase the anticoagulant activities of Sodium Citrate.Approved
TioclomarolTioclomarol may increase the anticoagulant activities of Sodium Citrate.Experimental
TipranavirTipranavir may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
TirofibanTirofiban may increase the anticoagulant activities of Sodium Citrate.Approved
Tolfenamic AcidTolfenamic Acid may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
TolmetinTolmetin may increase the anticoagulant activities of Sodium Citrate.Approved
TositumomabThe risk or severity of adverse effects can be increased when Sodium Citrate is combined with Tositumomab.Approved, Investigational
TranilastTranilast may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
TrapidilTrapidil may increase the anticoagulant activities of Sodium Citrate.Approved
TreprostinilTreprostinil may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
TribenosideTribenoside may increase the anticoagulant activities of Sodium Citrate.Experimental
TriflusalTriflusal may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
TriptolideTriptolide may increase the anticoagulant activities of Sodium Citrate.Investigational
Trolamine salicylateTrolamine salicylate may increase the anticoagulant activities of Sodium Citrate.Approved
TroxerutinTroxerutin may increase the anticoagulant activities of Sodium Citrate.Investigational
UrokinaseUrokinase may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational, Withdrawn
ValdecoxibValdecoxib may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational, Withdrawn
Vitamin EVitamin E may increase the anticoagulant activities of Sodium Citrate.Approved, Nutraceutical, Vet Approved
VorapaxarThe risk or severity of adverse effects can be increased when Vorapaxar is combined with Sodium Citrate.Approved
WarfarinWarfarin may increase the anticoagulant activities of Sodium Citrate.Approved
XimelagatranXimelagatran may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational, Withdrawn
ZaltoprofenZaltoprofen may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
ZeranolZeranol may decrease the anticoagulant activities of Sodium Citrate.Vet Approved
ZileutonZileuton may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational, Withdrawn
ZomepiracZomepirac may increase the anticoagulant activities of Sodium Citrate.Withdrawn
Food Interactions
Not Available

References

General References
  1. Mann KG, Whelihan MF, Butenas S, Orfeo T: Citrate anticoagulation and the dynamics of thrombin generation. J Thromb Haemost. 2007 Oct;5(10):2055-61. [PubMed:17883701]
  2. Palta S, Saroa R, Palta A: Overview of the coagulation system. Indian J Anaesth. 2014 Sep;58(5):515-23. doi: 10.4103/0019-5049.144643. [PubMed:25535411]
  3. Kramer L, Bauer E, Joukhadar C, Strobl W, Gendo A, Madl C, Gangl A: Citrate pharmacokinetics and metabolism in cirrhotic and noncirrhotic critically ill patients. Crit Care Med. 2003 Oct;31(10):2450-5. [PubMed:14530750]
  4. Zheng Y, Xu Z, Zhu Q, Liu J, Qian J, You H, Gu Y, Hao C, Jiao Z, Ding F: Citrate Pharmacokinetics in Critically Ill Patients with Acute Kidney Injury. PLoS One. 2013 Jun 18;8(6):e65992. doi: 10.1371/journal.pone.0065992. Print 2013. [PubMed:23824037]
  5. Li K, Xu Y: Citrate metabolism in blood transfusions and its relationship due to metabolic alkalosis and respiratory acidosis. Int J Clin Exp Med. 2015 Apr 15;8(4):6578-84. eCollection 2015. [PubMed:26131288]
  6. FDA Monograph: Sodium Citrate Tablet [Link]
  7. FDA Monograph: Sodium Citrate Liquid [Link]
  8. TOXNET: Trisodium Citrate [Link]
  9. SMPDB: Citric Acid Cycle [Link]
External Links
KEGG Drug
D05855
PubChem Compound
6224
PubChem Substance
310265067
ChemSpider
5989
ChEBI
53258
ChEMBL
CHEMBL1355
Wikipedia
Sodium_citrate
ATC Codes
B05CB02 — Sodium citrate
AHFS Codes
  • 56:04.00 — Antacids and Adsorbents
  • 20:12.04.92 — Miscellaneous Anticoagulants
  • 56:92.00 — Miscellaneous GI Drugs
FDA label
Download (124 KB)
MSDS
Download (77.2 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0CompletedTreatmentHeart Defects,Congenital / Respiratory Insufficiency1
1CompletedTreatmentIron-refractory, Iron-deficiency Anemia (IRIDA)1
1WithdrawnTreatmentArthritis1
1, 2CompletedOtherGlaucoma1
2Active Not RecruitingTreatmentCardiopulmonary Bypass / Surgery, Cardiac1
2CompletedTreatmentCataracts1
2CompletedTreatmentIron-Refractory Iron-Deficiency Anemia1
2CompletedTreatmentSymptomatic Focal Vitreomacular Adhesion1
2, 3CompletedTreatmentGlaucoma1
3Unknown StatusTreatmentRejection, Transplant1
4CompletedPreventionInflammatory Reaction1
4CompletedTreatmentPsoriasis / Sleep Apnea, Obstructive1
Not AvailableCompletedScreeningConotruncal Cardiac Defects / Heart Defects,Congenital / Parathyroid deficiency / Pulmonary Atresia / Pulmonary Valve Stenosis / Tetralogy Of Fallot1
Not AvailableCompletedTreatmentCataracts1
Not AvailableRecruitingNot AvailableIntra Operative Bleeding, Blood Salvage1
Not AvailableRecruitingTreatmentShock / Shock, Septic1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
LiquidIntravenous
Kit
SolutionIntraocular
Injection, solutionExtracorporeal
SolutionUnknown
SolutionUnknown4 g
LiquidIntravenous4 %
Injection, solutionIntravenous
SolutionIrrigation
PowderOral3.5 g
SolutionOphthalmic
Granule, effervescentOral
SolutionIntravenous
Capsule, delayed release pelletsOral
SolutionExtracorporeal
SolutionExtracorporeal40 mg/mL
LiquidIntraocular
PowderOral2.65 g
Kit
SyrupOral
Enema; liquidRectal
LiquidRectal
KitIntravenous
Tablet, chewableOral230 mg/1
LiquidOral
PowderOral2.645 g
PowderOral
SolutionIntravenous10 g/250mL
SolutionIntravenous2 g/50mL
SolutionIntravenous4 g/100mL
SolutionOral
SolutionExtracorporeal14 g/30mL
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)300MSDS
water solubility29.4g/LMSDS
Predicted Properties
PropertyValueSource
Water Solubility73.7 mg/mLALOGPS
logP-0.55ALOGPS
logP-1.3ChemAxon
logS-0.54ALOGPS
pKa (Strongest Acidic)3.05ChemAxon
pKa (Strongest Basic)-4.2ChemAxon
Physiological Charge-3ChemAxon
Hydrogen Acceptor Count7ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area140.62 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity68.14 m3·mol-1ChemAxon
Polarizability14.23 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as tricarboxylic acids and derivatives. These are carboxylic acids containing exactly three carboxyl groups.
Kingdom
Organic compounds
Super Class
Organic acids and derivatives
Class
Carboxylic acids and derivatives
Sub Class
Tricarboxylic acids and derivatives
Direct Parent
Tricarboxylic acids and derivatives
Alternative Parents
Tertiary alcohols / Carboxylic acid salts / Carboxylic acids / Organic sodium salts / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds
Substituents
Tricarboxylic acid or derivatives / Tertiary alcohol / Carboxylic acid salt / Organic alkali metal salt / Carboxylic acid / Organic oxygen compound / Organic oxide / Hydrocarbon derivative / Organic sodium salt / Organic salt
Molecular Framework
Aliphatic acyclic compounds
External Descriptors
organic sodium salt (CHEBI:53258)

Transporters

Kind
Protein
Organism
Homo sapiens
Pharmacological action
No
Actions
Substrate
General Function
Dicarboxylic acid transmembrane transporter activity
Specific Function
Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2-oxoglutarate, adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate, 2-ami...
Gene Name
SLC25A21
Uniprot ID
Q9BQT8
Uniprot Name
Mitochondrial 2-oxodicarboxylate carrier
Molecular Weight
33302.88 Da
References
  1. UniProt: Mitochondrial 2-oxodicarboxylate carrier [Link]
Kind
Protein
Organism
Human
Pharmacological action
No
Actions
Substrate
General Function
Low-affinity sodium:dicarboxylate symporter activity
Specific Function
Cotransport of sodium ions and dicarboxylates such as succinate and citrate.
Gene Name
SLC13A2
Uniprot ID
Q13183
Uniprot Name
Solute carrier family 13 member 2
Molecular Weight
64409.495 Da
References
  1. UniProt: Solute carrier family 13 member 2 [Link]
Kind
Protein
Organism
Homo sapiens
Pharmacological action
No
Actions
Substrate
General Function
Succinate transmembrane transporter activity
Specific Function
High-affinity sodium/citrate cotransporter that mediates citrate entry into cells. The transport process is electrogenic; it is the trivalent form of citrate rather than the divalent form that is r...
Gene Name
SLC13A5
Uniprot ID
Q86YT5
Uniprot Name
Solute carrier family 13 member 5
Molecular Weight
63061.605 Da
References
  1. Inoue K, Zhuang L, Maddox DM, Smith SB, Ganapathy V: Structure, function, and expression pattern of a novel sodium-coupled citrate transporter (NaCT) cloned from mammalian brain. J Biol Chem. 2002 Oct 18;277(42):39469-76. Epub 2002 Aug 11. [PubMed:12177002]
Kind
Protein
Organism
Homo sapiens
Pharmacological action
No
Actions
Substrate
General Function
Tricarboxylic acid transmembrane transporter activity
Specific Function
Involved in citrate-H(+)/malate exchange. Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD(+) for the glycolytic pathway.
Gene Name
SLC25A1
Uniprot ID
P53007
Uniprot Name
Tricarboxylate transport protein, mitochondrial
Molecular Weight
34012.46 Da
References
  1. Sun J, Aluvila S, Kotaria R, Mayor JA, Walters DE, Kaplan RS: Mitochondrial and Plasma Membrane Citrate Transporters: Discovery of Selective Inhibitors and Application to Structure/Function Analysis. Mol Cell Pharmacol. 2010;2(3):101-110. [PubMed:20686672]

Drug created on October 01, 2015 14:41 / Updated on June 17, 2018 20:13