Identification

Name
Picosulfuric acid
Accession Number
DB09268
Type
Small Molecule
Groups
Approved
Description

Picosulfuric acid (as sodium picosulfate) is a contact laxative used as a treatment for constipation or to prepare the large bowel before colonoscopy or surgery.

Structure
Thumb
Synonyms
  • Picosulfate
  • Picosulphate
Product Ingredients
IngredientUNIICASInChI Key
Sodium picosulfateVW106606Y810040-45-6GOZDTZWAMGHLDY-UHFFFAOYSA-L
Sodium picosulfate monohydrateLR57574HN81307301-38-7FHYUVJHZGPGDSP-UHFFFAOYSA-L
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
CitracleenSodium picosulfate (10 mg) + Citric Acid (10.97 g) + Magnesium oxide (3.5 g)Powder, for solutionOralLaboratorios Casen Fleet, S.L.U.Not applicableNot applicableCanada
ClenpiqSodium picosulfate (10 mg/160mL) + Citric Acid (12 g/160mL) + Magnesium oxide (3.5 g/160mL)LiquidOralFerring Pharmaceuticals2017-11-28Not applicableUs
Oral PurgativeSodium picosulfate (10 mg) + Citric Acid (12 g) + Magnesium oxide (3.5 g)Powder, for solutionOralOdan Laboratories Ltd2011-11-162017-06-22Canada
Pico-salaxSodium picosulfate (10 mg) + Citric Acid (12 g) + Magnesium oxide (3.5 g)Powder, for solutionOralFerring Pharmaceuticals2004-11-25Not applicableCanada
PicodanSodium picosulfate (10 mg) + Citric Acid (12 g) + Magnesium oxide (3.5 g)Powder, for solutionOralOdan Laboratories Ltd2007-10-172012-12-31Canada
PicofloSodium picosulfate (10 mg) + Citric Acid (12 g) + Magnesium oxide (3.5 g)Powder, for solutionOralPharmascience Inc2011-03-25Not applicableCanada
PrepopikSodium picosulfate (10 mg/16.2g) + Citric Acid (12 g/16.2g) + Magnesium oxide (3.5 g/16.2g)Powder, meteredOralFerring Pharmaceuticals2014-09-05Not applicableUs
PrepopikSodium picosulfate (10 mg/16.1g) + Citric Acid (12 g/16.1g) + Magnesium oxide (3.5 g/16.1g)Powder, meteredOralFerring Pharmaceuticals2012-07-16Not applicableUs
Purg-odanSodium picosulfate (10 mg) + Citric Acid (12 g) + Magnesium oxide (3.5 g)Powder, for solutionOralOdan Laboratories Ltd2009-02-16Not applicableCanada
International/Other Brands
Guttalax / Laxoberal / Laxoberon / Namilax / Pico-Salax / Picolax / Picoprep / Prepopik / Purg-Odan / Sodipic Picofast
Categories
UNII
95D580798S
CAS number
10040-34-3
Weight
Average: 437.44
Monoisotopic: 437.023908795
Chemical Formula
C18H15NO8S2
InChI Key
UJIDKYTZIQTXPM-UHFFFAOYSA-N
InChI
InChI=1S/C18H15NO8S2/c20-28(21,22)26-15-8-4-13(5-9-15)18(17-3-1-2-12-19-17)14-6-10-16(11-7-14)27-29(23,24)25/h1-12,18H,(H,20,21,22)(H,23,24,25)
IUPAC Name
{4-[(pyridin-2-yl)[4-(sulfooxy)phenyl]methyl]phenyl}oxidanesulfonic acid
SMILES
OS(=O)(=O)OC1=CC=C(C=C1)C(C1=CC=C(OS(O)(=O)=O)C=C1)C1=CC=CC=N1

Pharmacology

Indication

For cleansing of the colon as a preparation for colonoscopy in adults.

Structured Indications
Not Available
Pharmacodynamics

The stimulant laxative activity of sodium picosulfate (together with the osmotic laxative activity of combined magnesium citrate) produces a purgative effect which, when ingested with additional fluids, produces watery diarrhea.

Mechanism of action

Picosulfuric acid (as sodium picosulfate) is a contact laxative. Sodium picosulfate is hydrolyzed by colonic bacteria to form an active metabolite: bis-(p-hydroxy-phenyl)-pyridyl-2-methane, BHPM, which acts directly on the colonic mucosa to stimulate colonic peristalsis.

Absorption

Both picosulfate and its active metabolite BHPM had low systemic exposure (Cmax = 3.2 ng/mL and 0.05 ng/mL, respectively). Sodium picosulfate, which is a prodrug, is converted to its active metabolite, BHPM, by colonic bacteria. After administration of 2 packets of Prepopik® separated by 6 hours, in 16 healthy volunteers, sodium picosulfate reached a mean Cmax of 3.2 ng/mL at approximately 7 hours (Tmax). After the first packet the corresponding values were 2.3 ng/mL at 2 hours.

Volume of distribution

Not available

Protein binding

Not available

Metabolism

Sodium picosulfate is hydrolyzed by colonic bacteria to form an active metabolite: bis-(p-hydroxy-phenyl)-pyridyl-2-methane, BHPM. The reported Cmax of 0.05 ng/mL, which was below LLOQ (0.1 ng/mL), was the mean plasma level of a total of 16 subjects. When only 3 subjects with measurable level of BHPM in plasma are considered, Cmax was 0.54 ng/mL.

Route of elimination

excreted unchanged in urine. Urinary recovery for both picosulfate and BHPM were very low, 0.19% and 0.01% of administered drug, respectively.

Half life

7.4 hours

Clearance

Not available

Toxicity

In vitro: Sodium Picosulfate displays cytotoxic effects on cultured liver cells. 800 and 1600 mg/mL induces dose-dependently vacuolic and fatty change as well as necrosis combined with a lowered mitotic activity and a slight increase in LDH values of the rapidly growing cultured liver cells of rabbit. Comparable but less severe effects are observed in 4-day old liver cell cultures of rat, while liver cells cultured for 6 to 11 days tolerate 1600 mg/mL Sodium Picosulfate. In human liver cultures the number of cells is slightly lowered at 800 and 1600 mg/mL and the number of nuclei in division is decreased dependent on dose. [1]

In vivo

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
AmdinocillinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Amdinocillin.Investigational, Withdrawn
AmikacinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Amikacin.Approved, Investigational, Vet Approved
Aminosalicylic AcidThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Aminosalicylic Acid.Approved
AmithiozoneThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Amithiozone.Investigational
AmoxicillinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Amoxicillin.Approved, Vet Approved
Amphotericin BThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Amphotericin B.Approved, Investigational
AmpicillinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Ampicillin.Approved, Vet Approved
AmprenavirThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Amprenavir.Approved, Investigational
AnisomycinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Anisomycin.Experimental
ApramycinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Apramycin.Experimental, Vet Approved
AurodoxThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Aurodox.Experimental
AvibactamThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Avibactam.Approved
AvilamycinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Avilamycin.Vet Approved
AzidamfenicolThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Azidamfenicol.Experimental
AzithromycinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Azithromycin.Approved
AzlocillinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Azlocillin.Approved
AztreonamThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Aztreonam.Approved
BacampicillinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Bacampicillin.Approved, Investigational
BacitracinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Bacitracin.Approved, Vet Approved
BambermycinsThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Bambermycins.Vet Approved
BedaquilineThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Bedaquiline.Approved
BekanamycinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Bekanamycin.Experimental
Benzathine benzylpenicillinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Benzathine benzylpenicillin.Approved, Vet Approved
BenzylpenicillinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Benzylpenicillin.Approved, Vet Approved
BesifloxacinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Besifloxacin.Approved
Brefeldin AThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Brefeldin A.Experimental
CandicidinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Candicidin.Withdrawn
CapreomycinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Capreomycin.Approved
CarbenicillinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Carbenicillin.Approved, Investigational
Carbenicillin indanylThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Carbenicillin indanyl.Approved, Investigational
CarfecillinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Carfecillin.Experimental
CefacetrileThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cefacetrile.Approved
CefaclorThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cefaclor.Approved
CefadroxilThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cefadroxil.Approved, Vet Approved, Withdrawn
CefalotinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cefalotin.Approved, Vet Approved
CefamandoleThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cefamandole.Approved, Investigational
CefapirinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cefapirin.Approved, Vet Approved
CefatrizineThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cefatrizine.Experimental
CefazedoneThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cefazedone.Experimental
CefazolinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cefazolin.Approved
CefdinirThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cefdinir.Approved
CefditorenThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cefditoren.Approved, Investigational
CefepimeThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cefepime.Approved, Investigational
CefetametThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cefetamet.Experimental
CefiximeThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cefixime.Approved, Investigational
CefmenoximeThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cefmenoxime.Approved
CefmetazoleThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cefmetazole.Approved, Investigational
CefminoxThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cefminox.Approved
CefodizimeThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cefodizime.Experimental
CefonicidThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cefonicid.Approved, Investigational
CefoperazoneThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cefoperazone.Approved, Investigational
CeforanideThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Ceforanide.Approved
CefotaximeThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cefotaxime.Approved
CefotetanThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cefotetan.Approved
CefotiamThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cefotiam.Approved, Investigational
CefoxitinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cefoxitin.Approved
CefpiramideThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cefpiramide.Approved
CefpiromeThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cefpirome.Experimental
CefpodoximeThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cefpodoxime.Approved, Vet Approved
CefprozilThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cefprozil.Approved
CefradineThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cefradine.Approved
CefsulodinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cefsulodin.Experimental
CeftazidimeThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Ceftazidime.Approved
CeftezoleThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Ceftezole.Experimental
CeftibutenThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Ceftibuten.Approved, Investigational
CeftiofurThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Ceftiofur.Vet Approved
CeftizoximeThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Ceftizoxime.Approved, Investigational
CeftobiproleThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Ceftobiprole.Approved, Investigational
CeftriaxoneThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Ceftriaxone.Approved
CefuroximeThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cefuroxime.Approved
CephalexinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cephalexin.Approved, Investigational, Vet Approved
CephaloglycinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cephaloglycin.Approved
CephaloridineThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cephaloridine.Approved, Withdrawn
CethromycinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cethromycin.Investigational
ChloramphenicolThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Chloramphenicol.Approved, Vet Approved
Chloramphenicol succinateThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Chloramphenicol succinate.Experimental
ChloroxineThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Chloroxine.Approved
ChlortetracyclineThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Chlortetracycline.Approved, Investigational, Vet Approved
CiprofloxacinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Ciprofloxacin.Approved, Investigational
ClarithromycinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Clarithromycin.Approved
ClavulanateThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Clavulanate.Approved, Vet Approved
ClindamycinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Clindamycin.Approved, Vet Approved
ClofazimineThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Clofazimine.Approved, Investigational
CloxacillinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cloxacillin.Approved, Investigational, Vet Approved
ColistinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Colistin.Approved
CyclacillinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cyclacillin.Approved
CycloserineThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cycloserine.Approved
DactinomycinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Dactinomycin.Approved, Investigational
DalbavancinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Dalbavancin.Approved, Investigational
DalfopristinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Dalfopristin.Approved
DapsoneThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Dapsone.Approved, Investigational
DaptomycinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Daptomycin.Approved, Investigational
DecamethoxineThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Decamethoxine.Experimental
DemeclocyclineThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Demeclocycline.Approved
DibekacinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Dibekacin.Experimental
DicloxacillinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Dicloxacillin.Approved, Investigational, Vet Approved
DihydrostreptomycinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Dihydrostreptomycin.Investigational, Vet Approved
DirithromycinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Dirithromycin.Approved, Investigational
DoxycyclineThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Doxycycline.Approved, Investigational, Vet Approved
EfrotomycinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Efrotomycin.Vet Approved
EnoxacinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Enoxacin.Approved, Investigational
EnviomycinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Enviomycin.Approved
EpetraboroleThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Epetraborole.Investigational
EpicillinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Epicillin.Experimental
ErtapenemThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Ertapenem.Approved, Investigational
ErythromycinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Erythromycin.Approved, Investigational, Vet Approved
EthambutolThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Ethambutol.Approved
EthionamideThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Ethionamide.Approved
FidaxomicinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Fidaxomicin.Approved
FinafloxacinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Finafloxacin.Approved, Investigational
FlorfenicolThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Florfenicol.Vet Approved
FlucloxacillinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Flucloxacillin.Approved, Investigational
FosfomycinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Fosfomycin.Approved
FramycetinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Framycetin.Approved
FumagillinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Fumagillin.Experimental
FusafungineThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Fusafungine.Approved, Withdrawn
Fusidic AcidThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Fusidic Acid.Approved, Investigational
GamithromycinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Gamithromycin.Vet Approved
GarenoxacinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Garenoxacin.Investigational
GatifloxacinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Gatifloxacin.Approved, Investigational
GE-2270AThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with GE-2270A.Experimental
GemifloxacinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Gemifloxacin.Approved, Investigational
GentamicinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Gentamicin.Approved, Vet Approved
Gramicidin DThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Gramicidin D.Approved
GrepafloxacinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Grepafloxacin.Approved, Investigational, Withdrawn
HachimycinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Hachimycin.Experimental
Hygromycin BThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Hygromycin B.Vet Approved
ImipenemThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Imipenem.Approved
Isatoic anhydrideThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Isatoic anhydride.Experimental
IsepamicinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Isepamicin.Experimental
IsoniazidThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Isoniazid.Approved, Investigational
JosamycinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Josamycin.Approved, Investigational
KanamycinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Kanamycin.Approved, Investigational, Vet Approved
KitasamycinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Kitasamycin.Experimental
LanopepdenThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Lanopepden.Investigational
LasalocidThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Lasalocid.Vet Approved
LatamoxefThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Latamoxef.Approved, Investigational
LevofloxacinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Levofloxacin.Approved, Investigational
LincomycinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Lincomycin.Approved, Vet Approved
LinezolidThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Linezolid.Approved, Investigational
LomefloxacinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Lomefloxacin.Approved, Investigational
LoracarbefThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Loracarbef.Investigational, Withdrawn
LymecyclineThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Lymecycline.Approved, Investigational
MaduramicinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Maduramicin.Vet Approved
MaltotetraoseThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Maltotetraose.Experimental
MarbofloxacinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Marbofloxacin.Vet Approved
MepartricinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Mepartricin.Experimental
MeropenemThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Meropenem.Approved, Investigational
MetampicillinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Metampicillin.Experimental
MethacyclineThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Methacycline.Approved, Investigational
MeticillinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Meticillin.Approved, Investigational
MetronidazoleThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Metronidazole.Approved
MevastatinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Mevastatin.Experimental
MezlocillinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Mezlocillin.Approved, Investigational
MicronomicinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Micronomicin.Experimental
MidecamycinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Midecamycin.Experimental
MiglitolThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Miglitol.Approved
MinocyclineThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Minocycline.Approved, Investigational
MiocamycinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Miocamycin.Experimental
MizoribineThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Mizoribine.Investigational
MoxifloxacinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Moxifloxacin.Approved, Investigational
MupirocinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Mupirocin.Approved, Investigational, Vet Approved
NadifloxacinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Nadifloxacin.Investigational
NafcillinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Nafcillin.Approved, Investigational
Nalidixic AcidThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Nalidixic Acid.Approved, Investigational
NarasinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Narasin.Vet Approved
NatamycinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Natamycin.Approved
NebularineThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Nebularine.Experimental
NeomycinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Neomycin.Approved, Vet Approved
NetilmicinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Netilmicin.Approved, Investigational
NorfloxacinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Norfloxacin.Approved
NovobiocinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Novobiocin.Approved, Investigational, Vet Approved
NystatinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Nystatin.Approved, Vet Approved
OfloxacinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Ofloxacin.Approved
OleandomycinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Oleandomycin.Vet Approved
OritavancinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Oritavancin.Approved, Investigational
OxacillinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Oxacillin.Approved, Investigational
Oxolinic acidThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Oxolinic acid.Experimental
OxytetracyclineThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Oxytetracycline.Approved, Investigational, Vet Approved
OzenoxacinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Ozenoxacin.Approved, Investigational
ParomomycinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Paromomycin.Approved, Investigational
PazufloxacinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Pazufloxacin.Investigational
PecilocinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Pecilocin.Experimental
PefloxacinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Pefloxacin.Approved
PenimepicyclineThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Penimepicycline.Experimental
PentamycinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Pentamycin.Experimental
PhenoxymethylpenicillinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Phenoxymethylpenicillin.Approved, Vet Approved
PhosphoramidonThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Phosphoramidon.Experimental
Pipemidic acidThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Pipemidic acid.Experimental
PiperacillinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Piperacillin.Approved
PivampicillinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Pivampicillin.Approved
PivmecillinamThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Pivmecillinam.Approved
Polymyxin B SulfateThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Polymyxin B Sulfate.Approved, Vet Approved
PristinamycinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Pristinamycin.Experimental, Investigational
Procaine benzylpenicillinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Procaine benzylpenicillin.Approved, Vet Approved
PropicillinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Propicillin.Experimental
ProtionamideThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Protionamide.Approved, Investigational
PrulifloxacinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Prulifloxacin.Investigational
PyrazinamideThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Pyrazinamide.Approved, Investigational
PyrrolnitrinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Pyrrolnitrin.Experimental
QuinupristinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Quinupristin.Approved
RamoplaninThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Ramoplanin.Investigational
RelebactamThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Relebactam.Investigational
RetapamulinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Retapamulin.Approved
RibostamycinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Ribostamycin.Approved, Investigational
RifabutinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Rifabutin.Approved, Investigational
RifalazilThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Rifalazil.Investigational
RifampicinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Rifampicin.Approved
RifapentineThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Rifapentine.Approved, Investigational
RolitetracyclineThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Rolitetracycline.Approved
RoxarsoneThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Roxarsone.Vet Approved
RoxithromycinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Roxithromycin.Approved, Investigational, Withdrawn
SalinomycinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Salinomycin.Vet Approved
SirolimusThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Sirolimus.Approved, Investigational
SisomicinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Sisomicin.Investigational
SitafloxacinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Sitafloxacin.Experimental, Investigational
SparfloxacinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Sparfloxacin.Approved, Investigational
SpectinomycinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Spectinomycin.Approved, Investigational, Vet Approved
SpiramycinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Spiramycin.Approved
SqualamineThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Squalamine.Investigational
StreptomycinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Streptomycin.Approved, Vet Approved
SulbactamThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Sulbactam.Approved
SulbenicillinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Sulbenicillin.Experimental
SulfacetamideThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Sulfacetamide.Approved
SulfamerazineThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Sulfamerazine.Approved, Vet Approved
SulfameterThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Sulfameter.Approved
SulfamethoxypyridazineThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Sulfamethoxypyridazine.Experimental
SulfanilamideThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Sulfanilamide.Approved
SultamicillinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Sultamicillin.Approved, Investigational
TalampicillinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Talampicillin.Experimental
TazobactamThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Tazobactam.Approved
Tedizolid PhosphateThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Tedizolid Phosphate.Approved
TeicoplaninThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Teicoplanin.Approved, Investigational
TelavancinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Telavancin.Approved
TelithromycinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Telithromycin.Approved
TemafloxacinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Temafloxacin.Withdrawn
TemocillinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Temocillin.Approved, Investigational
TetracyclineThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Tetracycline.Approved, Vet Approved
ThalidomideThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Thalidomide.Approved, Investigational, Withdrawn
ThiamphenicolThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Thiamphenicol.Experimental, Investigational
ThiostreptonThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Thiostrepton.Vet Approved
Thiosulfuric acidThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Thiosulfuric acid.Approved, Investigational
TiamulinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Tiamulin.Vet Approved
TicarcillinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Ticarcillin.Approved, Investigational, Vet Approved
TigecyclineThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Tigecycline.Approved
TilmicosinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Tilmicosin.Investigational, Vet Approved
TobramycinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Tobramycin.Approved, Investigational
TroleandomycinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Troleandomycin.Approved
TunicamycinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Tunicamycin.Experimental
TylosinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Tylosin.Vet Approved
TyrothricinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Tyrothricin.Approved, Experimental
UbenimexThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Ubenimex.Experimental, Investigational
VancomycinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Vancomycin.Approved
ViomycinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Viomycin.Approved
VirginiamycinThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Virginiamycin.Vet Approved
Virginiamycin M1The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Virginiamycin M1.Experimental
Food Interactions
Not Available

References

General References
  1. Nishikawa J, Kast A: Toxicity study with sodium picosulfate in cultured liver cells of rabbit, rat and man. Arzneimittelforschung. 1981;31(2):321-5. [PubMed:7194649]
  2. Jauch R, Hammer R, Busch U, Kopitar Z, Ohnuma N, Niki T: [Pharmacokinetics and metabolism of sodium picosulfate in the rat (author's transl)]. Arzneimittelforschung. 1977;27(5):1045-50. [PubMed:577869]
  3. Kim DH, Hyun SH, Shim SB, Kobashi K: The role of intestinal bacteria in the transformation of sodium picosulfate. Jpn J Pharmacol. 1992 May;59(1):1-5. [PubMed:1507649]
  4. Drug Information [Link]
  5. FDA-CENTER FOR DRUG EVALUATION AND RESEARCH [Link]
  6. Wikipedia [Link]
External Links
PubChem Compound
5243
PubChem Substance
310265163
ChemSpider
5053
ChEMBL
CHEMBL1741134
Wikipedia
Sodium_picosulfate
ATC Codes
A06AB58 — Sodium picosulfate, combinationsA06AB08 — Sodium picosulfate
FDA label
Download (163 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedTreatmentHealthy Volunteers1
1, 2CompletedTreatmentNeed for Bowel Preparation1
2CompletedScreeningHealthy Volunteers1
2RecruitingDiagnosticBowel Preperation / Polyethylene Glycol With Ascorbic Acid / Sodium Picosulfate and Magnesium Citrate1
3CompletedNot AvailableBowel preparation therapy1
3CompletedOtherBowel preparation therapy1
3CompletedTreatmentBowel preparation therapy3
3CompletedTreatmentColonoscopy1
3CompletedTreatmentOccasional Constipation1
3Unknown StatusDiagnosticColonoscopy1
4Active Not RecruitingTreatmentPatients Undergoing Elective Colonoscopy1
4CompletedNot AvailableBowel preparation therapy1
4CompletedDiagnosticColonoscopy2
4CompletedDiagnosticHemodynamics / Hyponatremias1
4CompletedTreatmentCathartic Colon1
4CompletedTreatmentColonoscopy1
4Not Yet RecruitingDiagnosticBowel Preparation Solutions1
4Unknown StatusTreatmentBowel Preparation Solutions / Endoscopy1
Not AvailableCompletedNot AvailableBowel Cleanliness1
Not AvailableCompletedNot AvailableColonoscopy Preparation1
Not AvailableCompletedTreatmentInflammatory Bowel Diseases (IBD)1
Not AvailableRecruitingDiagnosticColonoscopy1
Not AvailableUnknown StatusDiagnosticBowel preparation therapy1
Not AvailableWithdrawnScreeningPatients Undergoing Screening or Surveillance Colonoscopy1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
LiquidOral
Powder, for solutionOral
Powder, meteredOral
Prices
Not Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US8450338No2008-10-102028-10-10Us
US8481083No2008-10-102028-10-10Us
US9827231No2014-06-232034-06-23Us

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0185 mg/mLALOGPS
logP-0.05ALOGPS
logP-1.5ChemAxon
logS-4.4ALOGPS
pKa (Strongest Acidic)-2.5ChemAxon
pKa (Strongest Basic)4.08ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count7ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area140.09 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity101.83 m3·mol-1ChemAxon
Polarizability40.3 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as diphenylmethanes. These are compounds containing a diphenylmethane moiety, which consists of a methane wherein two hydrogen atoms are replaced by two phenyl groups.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Benzene and substituted derivatives
Sub Class
Diphenylmethanes
Direct Parent
Diphenylmethanes
Alternative Parents
Phenylsulfates / Phenoxy compounds / Sulfuric acid monoesters / Pyridines and derivatives / Heteroaromatic compounds / Azacyclic compounds / Organopnictogen compounds / Organooxygen compounds / Organonitrogen compounds / Organic oxides
show 1 more
Substituents
Diphenylmethane / Phenylsulfate / Arylsulfate / Phenoxy compound / Pyridine / Sulfuric acid monoester / Sulfate-ester / Sulfuric acid ester / Organic sulfuric acid or derivatives / Heteroaromatic compound
show 10 more
Molecular Framework
Aromatic heteromonocyclic compounds
External Descriptors
Not Available

Enzymes

Kind
Protein
Organism
Escherichia coli O1:K1 / APEC
Pharmacological action
Unknown
Actions
Substrate
General Function
Catalyzes the transfer of sulfuryl groups between phenolic compounds.
Specific Function
Aryl sulfotransferase activity
Gene Name
assT
Uniprot ID
A0A0H2Z368
Uniprot Name
Arylsulfate sulfotransferase AssT
Molecular Weight
66545.805 Da
References
  1. Kim DH, Hyun SH, Shim SB, Kobashi K: The role of intestinal bacteria in the transformation of sodium picosulfate. Jpn J Pharmacol. 1992 May;59(1):1-5. [PubMed:1507649]

Drug created on October 27, 2015 21:06 / Updated on February 16, 2018 06:50