|DB00012||Darbepoetin alfa||For the treatment of anemia (from renal transplants or certain HIV treatment)|
|DB00016||Erythropoietin||Indicated in adult and paediatric patients for the:
- treatment of anemia due to Chronic Kidney Disease (CKD) in patients on dialysis and not on dialysis.
- treatment of anemia due to zidovudine in patients with HIV-infection.
- treatment of anemia due to the effects of concomitant myelosuppressive chemotherapy, and upon initiation, there is a minimum of two additional months of planned chemotherapy.
- reduction of allogeneic RBC transfusions in patients undergoing elective, noncardiac, nonvascular surgery.|
The cyanocobalamin nasal spray is indicated for the maintenance of vitamin B12 concentrations after normalization with intramuscular vitamin B12 therapy in patients with deficiency of this vitamin who have no nervous system involvement [FDA label].
Note: CaloMist [FDA label], the nasal spray form, has not been evaluated for the treatment of newly diagnosed vitamin B12 deficiency.
**Injection forms (subcutaneous, intramuscular)**
These forms are indicated for vitamin B12 deficiencies due to various causes, with or without neurologic manifestations [F3736]. Vitamin B12 deficiency is frequently caused by malabsorption, which is often associated with the following conditions [L5545]:
Addisonian (pernicious) anemia
Gastrointestinal pathology, dysfunction, or surgery, including gluten enteropathy or sprue, small bowel bacterial overgrowth, total or partial gastrectomy
Fish tapeworm infestation
Malignancy of the pancreas or bowel
Folic acid deficiency
Vitamin B12 supplements are widely available and indicated in patients who require supplementation for various reasons. Dose requirements for vitamin B12 which are higher than normal (caused by pregnancy, thyrotoxicosis, hemolytic anemia, hemorrhage, malignancy, hepatic and renal disease) can usually be achieved with oral supplementation [L5545]. Oral products of vitamin B12 are not recommended in patients with malabsorption, as these forms are primarily absorbed in the gastrointestinal tract [F3739]. |
|DB00158||Folic acid||Folic acid is indicated for the treatment of folic acid deficiency, megaloblastic anemia, and in anemias of nutritional origins, pregnancy, infancy, or childhood.|
|DB00200||Hydroxocobalamin||For treatment of pernicious anemia and the prevention and treatment of vitamin B12 deficiency arising from alcoholism, malabsorption, tapeworm infestation, celiac, hyperthyroidism, hepatic-biliary tract disease, persistent diarrhea, ileal resection, pancreatic cancer, renal disease, prolonged stress, vegan diets, macrobiotic diets or other restrictive diets. Also for the treatment of known or suspected cyanide poisoning.|
|DB01592||Iron||Used in preventing and treating iron-deficiency anemia.|
|DB08894||Peginesatide||Peginesatide is used for the treatment of anemia due to chronic kidney disease (CKD) in adult patients on dialysis |
|DB09107||Methoxy polyethylene glycol-epoetin beta||For the treatment of patients with anaemia associated with chronic kidney disease. Not a substitute for RBC transfusion if immediate correction of anemia is required.|
|DB13220||Ferrous aspartate||Not Available|
|DB13381||Sodium feredetate||Not Available|
|DB13423||Ferric hydroxide||Not Available|
|DB13569||Ferrous chloride||Not Available|
|DB13639||Ferrous tartrate||Not Available|
|DB13698||Ferrous carbonate||Not Available|
|DB13771||Ferric sodium citrate||Not Available|
|DB09146||Iron saccharate||Iron sucrose is elemental iron as an injection. It replenishes body iron stores in patients with iron deficiency.|
|DB14488||Ferrous gluconate||Used in preventing and treating iron-deficiency anemia.|
|DB14489||Ferrous succinate||Used in preventing and treating iron-deficiency anemia.|
|DB14490||Ferrous ascorbate||Used in preventing and treating iron-deficiency anemia.|
|DB14491||Ferrous fumarate||Used in preventing and treating iron-deficiency anemia.|
|DB14501||Ferrous glycine sulfate||Used in preventing and treating iron-deficiency anemia.|
|DB04847||Roxadustat||In clinical development for the treatment of anemia of chronic inflammatory disease.|