Identification

Logo pink
Are you a
new drug developer?
Contact us to learn more about our customized products and solutions.
Logo pink
Stay in the know!
As part of our commitment to providing the most up-to-date drug information, we will be releasing #DrugBankUpdates with our newly added curated drug pages.
#DrugBankUpdates
Name
Iron
Accession Number
DB01592
Type
Small Molecule
Groups
Approved
Description

A metallic element found in certain minerals, in nearly all soils, and in mineral waters. It is an essential constituent of hemoglobin, cytochrome, and other components of respiratory enzyme systems. Its chief functions are in the transport of oxygen to tissue (hemoglobin) and in cellular oxidation mechanisms. Depletion of iron stores may result in iron-deficiency anemia. Iron is used to build up the blood in anemia.

Structure
Thumb
Synonyms
  • Carbonyl iron
  • Eisen
  • Electrolytic iron
  • Fe
  • fer
  • Ferrum
  • Ferrum metallicum
  • Hierro
  • Iron powder
  • Iron, carbonyl
  • Iron, electrolytic
  • Iron, elemental
  • Iron, reduced
  • Reduced iron
Active Moieties
NameKindUNIICASInChI Key
Ferrous cationionicGW89581OWR15438-31-0CWYNVVGOOAEACU-UHFFFAOYSA-N
Product Images
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
DexironSolutionIntramuscular; IntravenousAmerican Regent, Inc1996-09-06Not applicableCanada
InfuferLiquidIntramuscular; IntravenousSandoz Canada Incorporated1997-02-072016-12-01Canada
Iron ChewsTablet, chewable15 mg/1OralMayne Pharma2009-01-012016-12-31Us
MonoferricSolutionIntravenousPharmacosmos A/S2018-10-17Not applicableCanada
VenoferSolution20 mgIntravenousAmerican Regent, Inc2001-06-05Not applicableCanada
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

    Learn more
  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

    Learn more
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Chelated Iron 25mg - CapletTabletOralHealth Wise Nutrition Inc.1995-12-312002-07-18Canada
Chelated Iron Supplement - TabTabletOralAlbion1996-09-062002-09-30Canada
Chelated Iron Tab 25mgTabletOralGahler Enterprises Ltd.1984-12-312008-07-17Canada
Fe-chelate TabTabletOralNutri West Products Ltd.1994-12-311997-08-05Canada
Fera Liq 16.7mg/15mlLiquidOralInno Vite Incorporated1987-12-312007-07-31Canada
IronCapsule40 mgOralSeroyal International Inc.1994-12-312008-10-09Canada
Iron Amino Chelate Tab 37mgTabletOralPure Life International Prods Inc.1992-12-312000-07-27Canada
Iron Chelate 25 mgTabletOralWn Pharmaceuticals Ltd.2002-03-132006-08-08Canada
Iron Proteinate Chelate Tab 25mgTabletOralCountry Health Laboratories Ltd.1982-12-312001-07-27Canada
Iron Proteinate Tab 25mgTabletOralAlbi Naturals1979-12-312008-07-17Canada
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

    Learn more
  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

    Learn more
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
ActyformIron (4.18 mg) + Copper (1 mg) + Magnesium (61.15 mg) + Zinc (9 mg)CapsuleOralTechnodiet S.E.N.C.1999-10-262008-08-13Canada
Advanced B & T FormulaIron (1.67 mg) + Ascorbic acid (33.3 mg) + Calcium (200 mg) + Chromium (33.33 mcg) + Copper (0.5 mg) + Cyanocobalamin (6.67 mcg) + Folic acid (0.133 mg) + Magnesium (83.3 mg) + Manganese (3.33 mg) + Nicotinamide (6.67 mg) + Calcium pantothenate (5 mg) + Phosphorus (100 mg) + Potassium (16.67 mg) + Pyridoxine hydrochloride (6.67 mg) + Riboflavin (2.67 mg) + Selenium (33.33 mcg) + Silicon (0.333 mg) + Sodium molybdate (16.67 mcg) + Thiamine (2.67 mg) + Vanadium (8.33 mg) + Vitamin D (66.67 unit) + Zinc (5 mg)CapsuleOralNutraceutical CorporationNot applicableNot applicableCanada
Calcium Et Magnesium Plus Vitamine D/fe/znIron (10 mg) + Calcium (400 mg) + Magnesium (167 mg) + Vitamin D (220 unit) + Zinc (10 mg)TabletOralLaboratoire Lalco Inc.1993-12-312008-07-29Canada
Chela Iron Plus C,b ComplexIron (50 mg) + Calcium ascorbate (100 mg) + Copper (2 mg) + Cyanocobalamin (30 mcg) + Folic acid (.4 mg) + Iodine (100 mcg) + Manganese (2 mg) + Nicotinamide (15 mg) + Pantothenic acid (15 mg) + Pyridoxine hydrochloride (5 mg) + Riboflavin (2 mg) + Thiamine hydrochloride (5 mg)TabletOralNu Life Nutrition Ltd.1986-12-312000-03-03Canada
Chelamins Plus TabIron (15 mg) + Calcium (350 mg) + Chromium (50 mcg) + Copper (1.5 mg) + Iodine (.15 mg) + Magnesium (175 mg) + Manganese (5 mg) + Phosphorus (75 mg) + Potassium (47.5 mg) + Selenium (25 mcg) + Vitamin D (200 unit) + Zinc (11.25 mg)TabletOralNu Life Nutrition Ltd.1988-12-312000-03-03Canada
Children's Chewable Multi-vitamin Complete With MineralsIron (4 mg) + Ascorbic acid (50 mg) + Biotin (30 mcg) + Calcium (160 mg) + Cholecalciferol (400 unit) + Copper (1 mg) + Cyanocobalamin (3 mcg) + Folic acid (0.1 mg) + Nicotinamide (15 mg) + Calcium pantothenate (10 mg) + Pyridoxine hydrochloride (1 mg) + Riboflavin (1.5 mg) + Thiamine hydrochloride (1.5 mg) + Vitamin A palmitate (5000 unit) + alpha-Tocopherol acetate (10 unit)TabletOralWn Pharmaceuticals Ltd.2000-03-012001-07-18Canada
Children's Chewable Vit and Min TabIron (5 mg) + Ascorbic acid (100 mg) + Beta carotene (5000 unit) + Biotin (10 mcg) + Calcium (65 mg) + Cholecalciferol (400 unit) + Choline bitartrate (5 mg) + Cyanocobalamin (10 mcg) + Folic acid (.2 mg) + Inositol (5 mg) + Magnesium (25 mg) + Manganese (1 mg) + Nicotinamide (10 mg) + Calcium pantothenate (10 mg) + Potassium (5 mg) + Pyridoxine hydrochloride (5 mg) + Riboflavin (5 mg) + Thiamine hydrochloride (5 mg) + Vitamin E (25 unit) + Zinc (2 mg)TabletOralGahler Enterprises Ltd.1990-12-312002-09-11Canada
Childrens Chewab Vitamin W Chel MineralsIron (5 mg) + Ascorbic acid (75 mg) + Biotin (50 mcg) + Cyanocobalamin (10 mcg) + D-alpha-Tocopherol acetate (25 unit) + Folic acid (10 mcg) + Iodine (1 mg) + Nicotinamide (10 mg) + Pantothenic acid (10 mg) + Pyridoxine (5 mg) + Riboflavin (5 mg) + Thiamine (5 mg) + Vitamin A (5000 unit) + Vitamin D (400 unit)TabletOralAnabolic Laboratories Inc.1981-12-311996-10-02Canada
CitraNatal 90 DHAIron (90 mg/1) + Ascorbic acid (120 mg/1) + Calcium citrate tetrahydrate (160 mg/1) + Cupric oxide (2 mg/1) + Docusate sodium (50 mg/1) + Folic acid (1 mg/1) + Nicotinamide (20 mg/1) + Potassium triiodide (150 ug/1) + Pyridoxine hydrochloride (20 mg/1) + Riboprine (3.4 mg/1) + Thiamine chloride (3 mg/1) + Vitamin D (400 [iU]/1) + Zinc oxide (25 mg/1) + alpha-Tocopherol acetate (30 [iU]/1)TabletOralMission Pharmacal2010-02-01Not applicableUs
CitraNatal DHAIron (27 mg/1) + Ascorbic acid (120 mg/1) + Calcium citrate tetrahydrate (125 mg/1) + Cupric oxide (2 mg/1) + Docusate sodium (50 mg/1) + Folic acid (1 mg/1) + Nicotinamide (20 mg/1) + Potassium Iodide (150 mg/1) + Pyridoxine hydrochloride (20 mg/1) + Riboflavin (3.4 mg/1) + Thiamine chloride (3 mg/1) + Vitamin D (400 [iU]/1) + Zinc oxide (25 mg/1) + alpha-Tocopherol acetate (30 [iU]/1)TabletOralMission Pharmacal2007-11-20Not applicableUs
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Active FEIron (75 mg/1) + Ascorbic acid (160 mg/1) + Beta carotene (2100 [iU]/1) + Cholecalciferol (400 [iU]/1) + Cupric oxide (1 mg/1) + Cyanocobalamin (30 ug/1) + DL-alpha tocopheryl acetate (40 [iU]/1) + Folic acid (1250 ug/1) + Magnesium oxide (30 mg/1) + Nicotinamide (20 mg/1) + Pyridoxine hydrochloride (20 mg/1) + Riboflavin (4 mg/1) + Thiamine hydrochloride (4 mg/1) + Zinc oxide (20 mg/1)TabletOralGm Pharmaceuticals2013-11-11Not applicableUs
Active OBIron (20 mg/1) + Ascorbic acid (100 mg/1) + Cholecalciferol (400 [iU]/1) + Cupric sulfate pentahydrate (2 mg/1) + Cyanocobalamin (30 ug/1) + D-alpha-Tocopherol acetate (30 [iU]/1) + Doconexent (320 mg/1) + Folic acid (1 mg/1) + Pyridoxine hydrochloride (20 mg/1) + Riboflavin (4 mg/1) + Thiamine mononitrate (2 mg/1) + Zinc oxide (30 mg/1)Capsule, liquid filledOralGm Pharmaceuticals2013-10-282017-03-31Us
BioFerr 90Iron (88.5 mg/1) + Ascorbic acid (138 mg/1) + Cyanocobalamin (16.8 ug/1) + Docusate sodium (55 mg/1) + Ferrous gluconate dihydrate (13.2 mg/1) + Folic acid (1.4 mg/1)Tablet, film coatedOralBiocomp Pharma, Inc.2014-07-01Not applicableUs
BumP DHAIron (15 mg/1) + Cobamamide (500 mg/1) + Flavin adenine dinucleotide (1 mg/1) + Flavin mononucleotide (2 mg/1) + Leucovorin (1 mg/1) + Levomefolate magnesium (1 mg/1) + Magnesium oxide (125 mg/1) + NADH (25 ug/1) + Omega-3 fatty acids (300 mg/1) + Potassium Iodide (250 ug/1) + Pyridoxal phosphate (5 mg/1) + Pyridoxine hydrochloride (20 mg/1) + Zinc glycinate (15 1/1)CapsuleOralCenturion Labs2017-03-242017-04-17Us
Cavan AlphaIron (27 mg/1) + Ascorbic acid (120 mg/1) + Beta carotene (3000 [iU]/1) + Calcium carbonate (230 mg/1) + Cholecalciferol (800 [iU]/1) + Cupric oxide (2 mg/1) + Cyanocobalamin (12 ug/1) + DL-alpha tocopheryl acetate (3 mg/1) + Folic acid (1 mg/1) + Iodine (220 ug/1) + Magnesium oxide (25 mg/1) + Nicotinamide (20 mg/1) + Omega-3 fatty acids (300 mg/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (4 mg/1) + Thiamine mononitrate (1.8 mg/1) + Zinc oxide (25 mg/1)KitOralSeton Pharmaceuticals2010-07-012013-09-30Us
Cavan Heme OBIron (28 mg/1) + Biotin (30 ug/1) + Cholecalciferol (400 [iU]/1) + Cupric sulfate pentahydrate (0.8 mg/1) + Cyanocobalamin (12 ug/1) + Folic acid (1 mg/1) + Niacin (17 mg/1) + Calcium pantothenate (10 mg/1) + Potassium Iodide (175 ug/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (1.6 mg/1) + Sodium selenate (65 ug/1) + Thiamine mononitrate (1.5 mg/1) + Zinc oxide (15 mg/1) + alpha-Tocopherol succinate (10 [iU]/1)TabletOralSeton Pharmaceuticals2010-08-032012-06-10Us
Cavan OneIron (20 mg/1) + Calcium (150 mg/1) + Calcium ascorbate dihydrate (25 mg/1) + Cholecalciferol (170 [iU]/1) + DL-alpha tocopheryl acetate (30 [iU]/1) + Doconexent (260 mg/1) + Ferrous asparto glycinate (7 mg/1) + Folic acid (1 mg/1) + Icosapent (40 mg/1) + Linoleic acid (30 mg/1) + Pyridoxine hydrochloride (25 mg/1) + alpha-Linolenic acid (30 mg/1)Capsule, gelatin coatedOralSeton Pharmaceuticals2009-10-302011-11-27Us
CentratexIron (106 mg/1) + Cupric sulfate (0.8 mg/1) + Cyanocobalamin (15 ug/1) + Folic acid (1 mg/1) + Magnesium sulfate (6.9 mg/1) + Manganese sulfate (1.3 mg/1) + Nicotinamide (30 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (5 mg/1) + Riboflavin (6 mg/1) + Sodium ascorbate (200 mg/1) + Thiamine mononitrate (10 mg/1) + Zinc sulfate, unspecified form (18.2 mg/1)CapsuleOralCenturion Labs2009-06-14Not applicableUs
CitraNatal 90 DHAIron (90 mg/1) + Ascorbic acid (120 mg/1) + Calcium citrate tetrahydrate (160 mg/1) + Cupric oxide (2 mg/1) + Docusate sodium (50 mg/1) + Folic acid (1 mg/1) + Nicotinamide (20 mg/1) + Potassium triiodide (150 ug/1) + Pyridoxine hydrochloride (20 mg/1) + Riboprine (3.4 mg/1) + Thiamine chloride (3 mg/1) + Vitamin D (400 [iU]/1) + Zinc oxide (25 mg/1) + alpha-Tocopherol acetate (30 [iU]/1)TabletOralMission Pharmacal2010-02-01Not applicableUs
CitraNatal 90 DHAIron (85 mg/1) + Ascorbic acid (120 mg/1) + Calcium citrate tetrahydrate (159 mg/1) + Cupric oxide (2 mg/1) + Docusate sodium (50 mg/1) + Ferrous gluconate dihydrate (5 mg/1) + Folic acid (1 mg/1) + Nicotinamide (20 mg/1) + Potassium Iodide (150 ug/1) + Pyridoxine hydrochloride (20 mg/1) + Riboflavin (3.4 mg/1) + Thiamine chloride (3 mg/1) + Thiamine mononitrate (4.54 mg/1) + Vitamin D (400 [iU]/1) + Zinc oxide (25 mg/1) + alpha-Tocopherol acetate (30 [iU]/1)TabletOralMission Pharmacal Company2014-04-11Not applicableUs
International/Other Brands
Ed-In-Sol / Fe-40 / Feosol (GlaxoSmithkline) / Feostat / Fer-In-Sol / Feratab (Upsher-Smith) / Ferate / Fergon / Ferralet / Ferretts / Ferro sanol / Ferro-Caps / Ferro-Time / Ferrousal / Siderol / Simron / Slow Fe / Vitedyn-Slo / Yieronia
Categories
UNII
E1UOL152H7
CAS number
7439-89-6
Weight
Average: 55.845
Monoisotopic: 55.934942133
Chemical Formula
Fe
InChI Key
XEEYBQQBJWHFJM-UHFFFAOYSA-N
InChI
InChI=1S/Fe
IUPAC Name
iron
SMILES
[Fe]

Pharmacology

Indication

Used in preventing and treating iron-deficiency anemia.

Associated Conditions
Associated Therapies
Pharmacodynamics

The major activity of supplemental iron is in the prevention and treatment of iron deficiency anemia. Iron has putative immune-enhancing, anticarcinogenic and cognition-enhancing activities.

Mechanism of action

Iron is necessary for the production of hemoglobin. Iron-deficiency can lead to decreased production of hemoglobin and a microcytic, hypochromic anemia.

TargetActionsOrganism
UTransferrin receptor protein 1Not AvailableHumans
UEgl nine homolog 1Not AvailableHumans
UHistone deacetylase 8
cofactor
Humans
UAlpha-hemoglobin-stabilizing proteinNot AvailableHumans
UHemoglobin subunit alphaNot AvailableHumans
UFrataxin, mitochondrialNot AvailableHumans
UFerritin heavy chainNot AvailableHumans
UFlap endonuclease 1Not AvailableHumans
UEndonuclease 8-like 1Not AvailableHumans
UEndonuclease 8-like 2Not AvailableHumans
UDNA polymerase betaNot AvailableHumans
UCeruloplasminNot AvailableHumans
USerotransferrinNot AvailableHumans
Additional Data Available
Adverse Effects

Comprehensive structured data on known drug adverse effects with statistical prevalence. MedDRA and ICD10 ids are provided for adverse effect conditions and symptoms.

Learn more
Additional Data Available
Contraindications

Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.

Learn more
Additional Data Available
Blackbox Warnings

Structured data representing warnings from the black box section of drug labels. These warnings cover important and dangerous risks, contraindications, or adverse effects.

Learn more
Absorption

The efficiency of absorption depends on the salt form, the amount administered, the dosing regimen and the size of iron stores. Subjects with normal iron stores absorb 10% to 35% of an iron dose. Those who are iron deficient may absorb up to 95% of an iron dose.

Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity

Acute iron overdosage can be divided into four stages. In the first stage, which occurs up to six hours after ingestion, the principal symptoms are vomiting and diarrhea. Other symptoms include hypotension, tachycardia and CNS depression ranging from lethargy to coma. The second phase may occur at 6-24 hours after ingestion and is characterized by a temporary remission. In the third phase, gastrointestinal symptoms recur accompanied by shock, metabolic acidosis, coma, hepatic necrosis and jaundice, hypoglycemia, renal failure and pulmonary edema. The fourth phase may occur several weeks after ingestion and is characterized by gastrointestinal obstruction and liver damage. In a young child, 75 milligrams per kilogram is considered extremely dangerous. A dose of 30 milligrams per kilogram can lead to symptoms of toxicity. Estimates of a lethal dosage range from 180 milligrams per kilogram and upwards. A peak serum iron concentration of five micrograms or more per ml is associated with moderate to severe poisoning in many.

Affected organisms
  • Humans and other mammals
Pathways
PathwayCategory
Nucleotide Sugars MetabolismMetabolic
Cysteine MetabolismMetabolic
Oxidation of Branched-Chain Fatty AcidsMetabolic
Tryptophan MetabolismMetabolic
Lovastatin Action PathwayDrug action
Cerivastatin Action PathwayDrug action
Aromatic L-Aminoacid Decarboxylase DeficiencyDisease
PhenylketonuriaDisease
HypercholesterolemiaDisease
Zellweger SyndromeDisease
Vitamin A DeficiencyDisease
Hereditary Coproporphyria (HCP)Disease
Congenital Erythropoietic Porphyria (CEP) or Gunther DiseaseDisease
Chondrodysplasia Punctata II, X-Linked Dominant (CDPX2)Disease
Smith-Lemli-Opitz Syndrome (SLOS)Disease
Galactosemia IIIDisease
Mevalonic AciduriaDisease
Glucose-6-phosphate Dehydrogenase DeficiencyDisease
Congenital Disorder of Glycosylation CDG-IIdDisease
Cystinosis, Ocular NonnephropathicDisease
The Oncogenic Action of FumarateDisease
Tyrosine MetabolismMetabolic
Inositol MetabolismMetabolic
Catecholamine BiosynthesisMetabolic
Taurine and Hypotaurine MetabolismMetabolic
Porphyrin MetabolismMetabolic
Pentose Phosphate PathwayMetabolic
Galactose MetabolismMetabolic
Pyrimidine MetabolismMetabolic
Simvastatin Action PathwayDrug action
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
3-Aza-2,3-Dihydrogeranyl DiphosphateIron can cause a decrease in the absorption of 3-Aza-2,3-Dihydrogeranyl Diphosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.
AlmasilateAlmasilate can cause a decrease in the absorption of Iron resulting in a reduced serum concentration and potentially a decrease in efficacy.
AloglutamolAloglutamol can cause a decrease in the absorption of Iron resulting in a reduced serum concentration and potentially a decrease in efficacy.
AluminiumAluminium can cause a decrease in the absorption of Iron resulting in a reduced serum concentration and potentially a decrease in efficacy.
Aluminium acetoacetateAluminium acetoacetate can cause a decrease in the absorption of Iron resulting in a reduced serum concentration and potentially a decrease in efficacy.
Aluminium glycinateAluminium glycinate can cause a decrease in the absorption of Iron resulting in a reduced serum concentration and potentially a decrease in efficacy.
Aluminium phosphateAluminium phosphate can cause a decrease in the absorption of Iron resulting in a reduced serum concentration and potentially a decrease in efficacy.
Aluminum hydroxideAluminum hydroxide can cause a decrease in the absorption of Iron resulting in a reduced serum concentration and potentially a decrease in efficacy.
BenazeprilIron can cause a decrease in the absorption of Benazepril resulting in a reduced serum concentration and potentially a decrease in efficacy.
BenazeprilatIron can cause a decrease in the absorption of Benazeprilat resulting in a reduced serum concentration and potentially a decrease in efficacy.
Additional Data Available
  • Extended Description
    Extended Description

    Extended description of the mechanism of action and particular properties of each drug interaction.

    Learn more
  • Severity
    Severity

    A severity rating for each drug interaction, from minor to major.

    Learn more
  • Evidence Level
    Evidence Level

    A rating for the strength of the evidence supporting each drug interaction.

    Learn more
  • Action
    Action

    An effect category for each drug interaction. Know how this interaction affects the subject drug.

    Learn more
Food Interactions
Not Available

References

Synthesis Reference

Walter Lugscheider, Paul Mullner, Wilhelm Schiffer, Alois Leutgob, "Arrangement for producing metals, such as molten pig iron, steel pre-material and ferroalloys." U.S. Patent US4617671, issued 0000.

US4617671
General References
Not Available
External Links
Human Metabolome Database
HMDB0015531
KEGG Compound
C00023
PubChem Compound
23925
PubChem Substance
46509190
ChemSpider
22368
ChEBI
18248
Therapeutic Targets Database
DAP001313
PharmGKB
PA450087
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
PDRhealth
PDRhealth Drug Page
Wikipedia
Iron
ATC Codes
B03AE02 — Iron, multivitamins and folic acidA11AA01 — Multivitamins and ironB03AE01 — Iron, vitamin b12 and folic acidB03AE04 — Iron, multivitamins and mineralsB03AE03 — Iron and multivitamins
AHFS Codes
  • 20:04.00 — Antianemia Drugs
  • 20:04.04 — Iron Preparations
  • 88:29.00* — Minerals
FDA label
Download (100 KB)
MSDS
Download (75.6 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0CompletedTreatmentIron Deficiency Anemia of Pregnancy1
0RecruitingPreventionBlood Transfusion Complication / Complications1
0WithdrawnDiagnosticCarcinoma, Ductal, Breast / Carcinoma, Intraductal, Noninfiltrating / Neoplasms, Breast1
1Active Not RecruitingTreatmentBioequivalance1
1CompletedNot AvailableHealthy Volunteers1
1CompletedBasic ScienceHealthy Volunteers1
1CompletedDiagnosticIron Deficiency Anemia (IDA)1
1CompletedOtherHealthy Volunteers1
1CompletedTreatmentAnemias / Deficiency Diseases / Hematologic Diseases / Iron Deficiency Anemia (IDA) / Iron Metabolism Disorders1
1CompletedTreatmentHaemodynamic Rebound1
1CompletedTreatmentInflammatory Bowel Diseases (IBD)1
1CompletedTreatmentIron Deficiency / Iron Deficiency Anemia (IDA)1
1CompletedTreatmentAcute iron intoxication / Thalassaemic disorders1
1TerminatedDiagnosticType 1 Insulin-Dependent Diabetes Mellitus1
1, 2CompletedTreatmentFriedreich's Ataxia1
1, 2CompletedTreatmentIron-Deficiency1
1, 2CompletedTreatmentRetinal Vein Occlusions(RVO)1
1, 2Not Yet RecruitingPreventionPrevention of Anemia1
1, 2TerminatedTreatmentAnemias / Cardiovascular Heart Disease1
1, 2TerminatedTreatmentPostural Orthostatic Tachycardia Syndrome (POTS)1
1, 2Unknown StatusTreatmentChronic Heart Failure (CHF) / Heart Diseases / Iron-Deficiency Anemias1
2Active Not RecruitingSupportive CareMetastatic Colorectal Cancer (MCRC)1
2CompletedDiagnosticDiagnosis / Dysmetabolic Hepatosiderosis / Ferroportin Disease / Hemochromatosis, Type 41
2CompletedPreventionAnemias1
2CompletedTreatmentAnemias2
2CompletedTreatmentAnemias / Iron Deficiency / Kidney Diseases1
2CompletedTreatmentAngiodysplasia / Gastric Antral Vascular Ectasia / Obscure Gastrointestinal Bleeding / Thalidomide1
2CompletedTreatmentChronic Kidney Disease (CKD)1
2CompletedTreatmentChronic Renal Failure (CRF)1
2CompletedTreatmentEnd Stage Renal Disease (ESRD)1
2CompletedTreatmentIron Deficiency Anemia (IDA)1
2CompletedTreatmentIron Deficiency / Pulmonary Arterial Hypertension (PAH)1
2CompletedTreatmentIron-Refractory Iron-Deficiency Anemia1
2CompletedTreatmentAcute iron intoxication / Myelodysplastic Syndromes1
2CompletedTreatmentAcute iron intoxication / Myelodysplastic Syndrome1
2CompletedTreatmentPregnancy1
2CompletedTreatmentRestless Legs Syndrome (RLS)1
2RecruitingTreatmentAnemia of Chronic Disease / Hip Arthropathy / Iron Deficiency Anemia (IDA) / Knee Arthropathy1
2RecruitingTreatmentAnemias / Congenital Heart Disease (CHD) / Cyanosis / Cyanotic Congenital Heart Disease1
2RecruitingTreatmentIron Deficiency Anemia (IDA) / Restless Legs Syndrome (RLS)1
2SuspendedTreatmentPulmonary Hypertension (PH)1
2TerminatedNot AvailableCrohn's Disease (CD) / Mild or Moderate Anaemia / Ulcerative Colitis1
2TerminatedPreventionAnemias / Neoplasms1
2TerminatedTreatmentAnemias / Unexplained Anemia (UAE)1
2Unknown StatusPreventionBreast Cancer1
2Unknown StatusTreatmentAnemias1
2WithdrawnTreatmentAnemias1
2WithdrawnTreatmentAnemias / Functional Iron Deficiency / Traumas1
2WithdrawnTreatmentInflammatory Bowel Diseases (IBD) / Iron Deficiency Anemia (IDA)1
2WithdrawnTreatmentIron Deficiency1
2, 3CompletedTreatmentAnemias1
2, 3CompletedTreatmentAnemias / Renal Failure1
2, 3CompletedTreatmentHaematological Malignancies1
2, 3CompletedTreatmentIron Deficiency Anemia (IDA)1
2, 3TerminatedTreatmentMinor burns1
2, 3Unknown StatusTreatmentIron Chelation / Thalassemia Major (TM) / Vitamin c1
3Active Not RecruitingTreatmentAnemias2
3CompletedDiagnosticAnemias1
3CompletedOtherChronic Kidney Disease (CKD)1
3CompletedOtherHealthy Volunteers1
3CompletedPreventionChild's Development / Diarrhea / Febrile Illness / Growth / Pneumonia1
3CompletedPreventionIron Deficiency1
3CompletedPreventionNutrition1
3CompletedSupportive CareAnemias / Postoperative Blood Loss1
3CompletedTreatmentAnemias8
3CompletedTreatmentAnemias / Chronic Lymphocytic Leukaemia (CLL) / Multiple Myeloma (MM) / Non-Hodgkin's Lymphoma (NHL)1
3CompletedTreatmentAnemias / Crohn's Disease (CD) / Inflammatory Bowel Diseases (IBD) / Iron Deficiency / Iron-Deficiency Anemias / Ulcerative Colitis1
3CompletedTreatmentChemotherapy Induced Anemia / Non-Myeloid Malignancies1
3CompletedTreatmentChronic Kidney Disease (CKD) / Iron Deficiency Anemia (IDA)1
3CompletedTreatmentChronic Kidney Disease (CKD) / Iron-Deficiency Anemias1
3CompletedTreatmentChronic Kidney Disease Requiring Chronic Dialysis2
3CompletedTreatmentCongestive Heart Failure1
3CompletedTreatmentFibromyalgia, Primary1
3CompletedTreatmentGynecologic Cancers1
3CompletedTreatmentIDA - Iron Deficiency Anemia2
3CompletedTreatmentInflammatory Bowel Diseases (IBD)1
3CompletedTreatmentIron Deficiency1
3CompletedTreatmentIron Deficiency Anemia (IDA)8
3CompletedTreatmentImpaired kidney function / Iron Deficiency Anemia (IDA)1
3CompletedTreatmentIron Deficiency Anemia of Pregnancy1
3CompletedTreatmentIron-Deficiency Anemias1
3CompletedTreatmentIron-Deficiency Anemias / Weight Loss1
3CompletedTreatmentUterine Leiomyomas1
3Not Yet RecruitingTreatmentIron-Deficiency / Postpartum Anemia Nos1
3RecruitingTreatmentAnemias2
3RecruitingTreatmentChronic Kidney Disease Requiring Chronic Dialysis / Hyperphosphataemia1
3RecruitingTreatmentChronic Kidney Disease; Iron Deficiency Anemia1
3RecruitingTreatmentColorectal Cancers / Iron-Deficiency Anemias1
3RecruitingTreatmentCrohn's Disease (CD) / Inflammatory Bowel Diseases (IBD) / Iron-Deficiency Anemias1
3RecruitingTreatmentFerropenic Anemia / Heart Failure With Normal Ejection Fraction1
3RecruitingTreatmentIron Deficiency Anemia (IDA)1
3RecruitingTreatmentMild and Moderate Iron-deficiency Anaemia1
3TerminatedTreatmentChronic Renal Failure (CRF)1
3TerminatedTreatmentIron Deficiency Anemia (IDA)1
3TerminatedTreatmentIron Deficiency Anemia (IDA) / Nondialysis Dependent Chronic Kidney Disease / Nondialysis-dependent chronic kidney disease1
3WithdrawnTreatmentAnemias / Chronic Heart Failure (CHF) / Chronic Kidney Disease (CKD)1
3WithdrawnTreatmentLeiomyomas1
4Active Not RecruitingOtherIron-Deficiency1
4Active Not RecruitingTreatmentAnemias / Hemodialysis Treatment1
4Active Not RecruitingTreatmentIron Deficiency Anemia (IDA)1
4CompletedBasic ScienceAnemias1
4CompletedDiagnosticAnemias / Chronic Renal Failure (CRF)1
4CompletedHealth Services ResearchPregnancy1
4CompletedPreventionAnemia Ferropenic / Risk of Hemoconcentration (Iron Levels >130g/L)1
4CompletedPreventionIron-Deficiency1
4CompletedTreatmentAnemias2
4CompletedTreatmentAnemias / Chronic Kidney Disease (CKD)1
4CompletedTreatmentAnemias / Complications, Pregnancy1
4CompletedTreatmentAnemias / Gastrointestinal Hemorrhage1
4CompletedTreatmentAnemias / Puerperal Disorders1
4CompletedTreatmentChronic Kidney Disease (CKD) / Heart Failure / Iron Deficiency1
4CompletedTreatmentChronic Kidney Disease (CKD) / Iron Deficiency Anemia (IDA)1
4CompletedTreatmentChronic Renal Failure (CRF) / Hemodialysis Treatment / Iron Deficiency Anemia (IDA) / Renal Anemia1
4CompletedTreatmentChronic Renal Failure (CRF) / Iron-Deficiency Anemias2
4CompletedTreatmentDiabetic Macular Edema (DME)1
4CompletedTreatmentInflammatory Bowel Diseases (IBD) / Iron Deficiency1
4CompletedTreatmentIron Deficiency1
4CompletedTreatmentIron Deficiency Anemia (IDA)3
4CompletedTreatmentKnee Osteoarthritis (Knee OA) / Postoperative Anaemia1
4CompletedTreatmentLiposomated Iron / Parenteral Iron Therapy / Y-de-Roux Gastric By-Pass1
4CompletedTreatmentMeconium Aspiration Syndrome / Persistent Pulmonary Hypertension of Newborn (PPHN)1
4CompletedTreatmentObesity, Childhood1
4CompletedTreatmentThe Treatment of Iron Deficiency Anemia in Patients With Chronic Kidney Disease1
4CompletedTreatmentTreatment of Iron Deficiency Anemia in Pregnancy1
4Enrolling by InvitationPreventionHematologic Pregnancy Complications1
4Enrolling by InvitationTreatmentPost Gastrectomy Anemia1
4Not Yet RecruitingTreatmentAnemias / Bowel Diseases, Inflammatory1
4Not Yet RecruitingTreatmentChronic Heart Failure (CHF) / Iron-Deficiency1
4Not Yet RecruitingTreatmentHeart Failure1
4RecruitingSupportive CareIron Deficiency1
4RecruitingTreatmentAnemias / Hematopoietic Stem Cell Transplantation (HSCT) / Malignant Lymphomas1
4RecruitingTreatmentAnemias / Major Abdominal Surgery / Pre-operative1
4RecruitingTreatmentBacterial Infection Due to Helicobacter Pylori (H. Pylori) / Complications, Pregnancy / Iron Deficiency Anemia (IDA)1
4RecruitingTreatmentHeart Failure With Reduced Ejection Fraction (HFrEF) / Iron Deficiency1
4RecruitingTreatmentHeart Failure / Iron Deficiency / Left Ventricular Systolic Dysfunction1
4RecruitingTreatmentInflammatory Bowel Diseases (IBD)1
4RecruitingTreatmentInflammatory Bowel Diseases (IBD) / Iron Deficiency Anemia (IDA)1
4RecruitingTreatmentIntravenous Drug Usage / Iron-Deficiency Anemias / Neoplasms, Colorectal / Surgery, Colorectal1
4RecruitingTreatmentIron Deficiency Anemia (IDA)2
4RecruitingTreatmentIron-Deficiency Anemias / Pregnancy1
4SuspendedTreatmentIron Deficiency Anemia (IDA) / Perioperative Blood Conservation1
4TerminatedPreventionHeart; Dysfunction Postoperative, Cardiac Surgery / Iron-Deficiency Anemias1
4TerminatedTreatmentAnemias1
4TerminatedTreatmentChronic Kidney Disease (CKD) / Iron-Deficiency Anemias1
4TerminatedTreatmentDiabetes Mellitus (DM) / Ulcus Cruris1
4TerminatedTreatmentLymphoid Disease / Solid Cancer Metastatic Disease1
4Unknown StatusPreventionAnemias / Child Behavior Disorders / Cognitive Manifestations / Iron-Deficiency1
4Unknown StatusPreventionAnemias / Iron Deficiency1
4Unknown StatusTreatmentAnemias / Iron Deficiency1
4Unknown StatusTreatmentIron Deficiency Anemia (IDA) / Neoplasms, Colorectal1
4Unknown StatusTreatmentPostoperative Anaemia1
4WithdrawnTreatmentHelicobacter Pylori / Iron-Deficiency Anemias1
4WithdrawnTreatmentIron Deficiency Anemia (IDA)2
Not AvailableActive Not RecruitingDiagnosticIron Absorption1
Not AvailableActive Not RecruitingPreventionAcute iron intoxication / Iron Metabolism / Preterms1
Not AvailableCompletedNot AvailableAnemias / Iron Deficiency / Plasmodium Infections / Schistosomiasis Infection1
Not AvailableCompletedNot AvailableChronic Heart Failure (CHF) / Chronic Kidney Disease (CKD) / Iron Deficiency Anemia (IDA)1
Not AvailableCompletedNot AvailableIron Deficiency Anemia (IDA)1
Not AvailableCompletedNot AvailableIron-Deficiency1
Not AvailableCompletedBasic ScienceAnemias / Systemic Inflammatory Process1
Not AvailableCompletedBasic ScienceCardiovascular Heart Disease1
Not AvailableCompletedBasic ScienceCritical Illness1
Not AvailableCompletedBasic ScienceMountain Sickness / Pulmonary Hypertension (PH)1
Not AvailableCompletedDiagnosticHFE-Associated Hereditary Hemochromatosis / Myocardial Iron Overload1
Not AvailableCompletedPreventionDiarrhea / Morbidity / Pneumonia / The Mortality Rate1
Not AvailableCompletedPreventionIron Deficiency Anemia (IDA)1
Not AvailableCompletedPreventionIron Metabolic Homeostasis1
Not AvailableCompletedPreventionNutritional Status1
Not AvailableCompletedPreventionPostpartum Anemia1
Not AvailableCompletedPreventionVisceral Leishmaniasis1
Not AvailableCompletedTreatmentAging1
Not AvailableCompletedTreatmentAnemias4
Not AvailableCompletedTreatmentBacterial Infection Due to Helicobacter Pylori (H. Pylori) / Children / Iron Deficiency Anemia (IDA) / No Systemic Infection / Not Severely Malnourished1
Not AvailableCompletedTreatmentBronchial Diseases / Coughing / Iron Deficiency / Laryngeal Diseases1
Not AvailableCompletedTreatmentCrohn's Disease (CD)1
Not AvailableCompletedTreatmentICU Anemia / Traumas1
Not AvailableCompletedTreatmentIron Deficiency Anemia (IDA)3
Not AvailableCompletedTreatmentVulvovaginal Candidiasis1
Not AvailableNot Yet RecruitingNot AvailableIron Deficiency Anemia (IDA)1
Not AvailableNot Yet RecruitingPreventionAnemia of Pregnancy1
Not AvailableNot Yet RecruitingPreventionAnemias / Hip Fracture1
Not AvailableNot Yet RecruitingPreventionSurgical Blood Loss1
Not AvailableNot Yet RecruitingTreatmentIron Deficiency Anemia (IDA)1
Not AvailableRecruitingNot AvailableAnemias / Arthroplasty, Replacement, Hip / Arthroplasty, Replacement, Knee1
Not AvailableRecruitingNot AvailableChronic Non Healing Wound / Diabetic Foot Ulcers (DFU) / Pressure Ulcers / Surgical Wound Dehiscence / Venous Stasis Ulcers (VSU)1
Not AvailableRecruitingOtherDysmetabolic Iron Overload Syndrome1
Not AvailableRecruitingOtherGestational Diabetes Mellitus (GDM) / Impaired Glucose Tolerance / Iron Deficiency Anemia of Pregnancy / Iron Metabolism Disorders1
Not AvailableRecruitingPreventionFacial Asymmetry / Prognathism / Retrognathism1
Not AvailableRecruitingTreatmentAnemias1
Not AvailableRecruitingTreatmentComplex Valvular Heart Surgery1
Not AvailableRecruitingTreatmentGluten Enteropathy / Iron Deficiency (Without Anemia)1
Not AvailableRecruitingTreatmentGluten Enteropathy / Iron Deficiency Anemia (IDA)1
Not AvailableRecruitingTreatmentIron Deficiency Anemia Treatment1
Not AvailableRecruitingTreatmentPregnancy Complications, Hematologic1
Not AvailableSuspendedDiagnosticFollicular Thyroid Cancer Lymph Node Metastasis / Metastatic Medullary Thyroid Cancer / Papillary Carcinoma of Thyroid Metastatic to Regional Lymph Node1
Not AvailableTerminatedOtherAnemias / End Stage Renal Disease (ESRD)1
Not AvailableTerminatedPreventionAnemias / Plasmodium Infections1
Not AvailableTerminatedTreatmentIron-Deficiency Anemias1
Not AvailableUnknown StatusScreeningRetinopathy of Prematurity1
Not AvailableUnknown StatusTreatmentRenal Failure Chronic Requiring Hemodialysis1
Not AvailableWithdrawnTreatmentIDA in the Post-bariatric Surgical Patient1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
  • Accucaps Industries Ltd.
  • Breckenridge Pharmaceuticals
  • Cardinal Health
  • Centrix Pharmaceuticals
  • Contract Pharm
  • Cypress Pharmaceutical Inc.
  • Dayton Pharmaceuticals
  • Edwards Pharmaceuticals
  • Equipharm Inc.
  • Haupt Pharma
  • Lehigh Valley Technologies Inc.
  • Mallinckrodt Inc.
  • Marlop Pharmaceuticals Inc.
  • Midlothian Labs
  • Nature's Bounty
  • Physicians Total Care Inc.
  • Provident Pharmaceuticals LLC
  • Puretek Corp.
  • Rising Pharmaceuticals
  • River's Edge Pharmaceuticals
  • Roxmar Laboratories
  • Seyer Pharmatec Inc.
Dosage forms
FormRouteStrength
Capsule, liquid filledOral
SolutionIntramuscular; Intravenous
Tablet, chewableOral
LiquidOral
Tablet, delayed releaseOral
Tablet, coatedOral
LiquidIntramuscular; Intravenous
CapsuleOral40 mg
TabletOral
Tablet, chewableOral15 mg/1
SolutionIntravenous
Solution / dropsOral
SolutionOral
Powder, for solutionOral
LiquidOral
CapsuleOral50 mg/1
LiquidOral15 mg/1mL
CapsuleOral150 mg/1
TabletOral
Capsule, gelatin coatedOral
CapsuleOral
Tablet, extended releaseOral
SolutionIntravenous20 mg
Tablet, film coatedOral
KitOral
SuspensionOral15 mg/1.25mL
Prices
Unit descriptionCostUnit
Iron chews 15 mg tablet chew0.29USD tablet
Ferrous sulfate 28 mg tablet0.04USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US6667050No2003-12-232019-04-06Us
Additional Data Available
  • Filed On
    Filed On

    The date on which a patent was filed with the relevant government.

    Learn more

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)1538 °CNot Available
Predicted Properties
PropertyValueSource
logP-0.77ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity0 m3·mol-1ChemAxon
Polarizability1.78 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9838
Blood Brain Barrier+0.9733
Caco-2 permeable+0.7354
P-glycoprotein substrateNon-substrate0.885
P-glycoprotein inhibitor INon-inhibitor0.9787
P-glycoprotein inhibitor IINon-inhibitor0.9858
Renal organic cation transporterNon-inhibitor0.9108
CYP450 2C9 substrateNon-substrate0.8466
CYP450 2D6 substrateNon-substrate0.8259
CYP450 3A4 substrateNon-substrate0.8158
CYP450 1A2 substrateNon-inhibitor0.8807
CYP450 2C9 inhibitorNon-inhibitor0.9373
CYP450 2D6 inhibitorNon-inhibitor0.9708
CYP450 2C19 inhibitorNon-inhibitor0.9553
CYP450 3A4 inhibitorNon-inhibitor0.988
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.882
Ames testNon AMES toxic0.9633
CarcinogenicityCarcinogens 0.664
BiodegradationReady biodegradable0.7326
Rat acute toxicity2.0135 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9547
hERG inhibition (predictor II)Non-inhibitor0.9746
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of inorganic compounds known as homogeneous transition metal compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a transition metal atom.
Kingdom
Inorganic compounds
Super Class
Homogeneous metal compounds
Class
Homogeneous transition metal compounds
Sub Class
Not Available
Direct Parent
Homogeneous transition metal compounds
Alternative Parents
Not Available
Substituents
Homogeneous transition metal
Molecular Framework
Not Available
External Descriptors
elemental iron (CHEBI:82664)

Targets

Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Virus receptor activity
Specific Function
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferri...
Gene Name
TFRC
Uniprot ID
P02786
Uniprot Name
Transferrin receptor protein 1
Molecular Weight
84870.665 Da
References
  1. Hemadi M, Ha-Duong NT, El Hage Chahine JM: The mechanism of iron release from the transferrin-receptor 1 adduct. J Mol Biol. 2006 May 12;358(4):1125-36. Epub 2006 Mar 13. [PubMed:16564538]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Peptidyl-proline dioxygenase activity
Specific Function
Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific prol...
Gene Name
EGLN1
Uniprot ID
Q9GZT9
Uniprot Name
Egl nine homolog 1
Molecular Weight
46020.585 Da
References
  1. Davidson TL, Chen H, Di Toro DM, D'Angelo G, Costa M: Soluble nickel inhibits HIF-prolyl-hydroxylases creating persistent hypoxic signaling in A549 cells. Mol Carcinog. 2006 Jul;45(7):479-89. [PubMed:16649251]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Cofactor
General Function
Transcription factor binding
Specific Function
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an impo...
Gene Name
HDAC8
Uniprot ID
Q9BY41
Uniprot Name
Histone deacetylase 8
Molecular Weight
41757.29 Da
References
  1. Gantt SL, Gattis SG, Fierke CA: Catalytic activity and inhibition of human histone deacetylase 8 is dependent on the identity of the active site metal ion. Biochemistry. 2006 May 16;45(19):6170-8. [PubMed:16681389]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation. It is predicted to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia.
Specific Function
Hemoglobin binding
Gene Name
AHSP
Uniprot ID
Q9NZD4
Uniprot Name
Alpha-hemoglobin-stabilizing protein
Molecular Weight
11840.325 Da
References
  1. Zhou S, Olson JS, Fabian M, Weiss MJ, Gow AJ: Biochemical fates of alpha hemoglobin bound to alpha hemoglobin-stabilizing protein AHSP. J Biol Chem. 2006 Oct 27;281(43):32611-8. Epub 2006 Aug 10. [PubMed:16901899]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Oxygen transporter activity
Specific Function
Involved in oxygen transport from the lung to the various peripheral tissues.
Gene Name
HBA1
Uniprot ID
P69905
Uniprot Name
Hemoglobin subunit alpha
Molecular Weight
15257.405 Da
References
  1. Zhou S, Olson JS, Fabian M, Weiss MJ, Gow AJ: Biochemical fates of alpha hemoglobin bound to alpha hemoglobin-stabilizing protein AHSP. J Biol Chem. 2006 Oct 27;281(43):32611-8. Epub 2006 Aug 10. [PubMed:16901899]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has only been shown using heterologous overexpression systems. Modulates the RNA-binding activity of ACO1.
Specific Function
2 iron, 2 sulfur cluster binding
Gene Name
FXN
Uniprot ID
Q16595
Uniprot Name
Frataxin, mitochondrial
Molecular Weight
23134.895 Da
References
  1. Bencze KZ, Kondapalli KC, Cook JD, McMahon S, Millan-Pacheco C, Pastor N, Stemmler TL: The structure and function of frataxin. Crit Rev Biochem Mol Biol. 2006 Sep-Oct;41(5):269-91. [PubMed:16911956]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Iron ion binding
Specific Function
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after ...
Gene Name
FTH1
Uniprot ID
P02794
Uniprot Name
Ferritin heavy chain
Molecular Weight
21225.47 Da
References
  1. Toussaint L, Bertrand L, Hue L, Crichton RR, Declercq JP: High-resolution X-ray structures of human apoferritin H-chain mutants correlated with their activity and metal-binding sites. J Mol Biol. 2007 Jan 12;365(2):440-52. Epub 2006 Oct 7. [PubMed:17070541]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Specific Function
5'-3' exonuclease activity
Gene Name
FEN1
Uniprot ID
P39748
Uniprot Name
Flap endonuclease 1
Molecular Weight
42592.635 Da
References
  1. Hegde ML, Hegde PM, Holthauzen LM, Hazra TK, Rao KS, Mitra S: Specific Inhibition of NEIL-initiated repair of oxidized base damage in human genome by copper and iron: potential etiological linkage to neurodegenerative diseases. J Biol Chem. 2010 Sep 10;285(37):28812-25. doi: 10.1074/jbc.M110.126664. Epub 2010 Jul 9. [PubMed:20622253]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Not Available
Specific Function
Not Available
Gene Name
NEIL1
Uniprot ID
Q96FI4
Uniprot Name
Endonuclease 8-like 1
Molecular Weight
43683.625 Da
References
  1. Hegde ML, Hegde PM, Holthauzen LM, Hazra TK, Rao KS, Mitra S: Specific Inhibition of NEIL-initiated repair of oxidized base damage in human genome by copper and iron: potential etiological linkage to neurodegenerative diseases. J Biol Chem. 2010 Sep 10;285(37):28812-25. doi: 10.1074/jbc.M110.126664. Epub 2010 Jul 9. [PubMed:20622253]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Zinc ion binding
Specific Function
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preferenc...
Gene Name
NEIL2
Uniprot ID
Q969S2
Uniprot Name
Endonuclease 8-like 2
Molecular Weight
36826.285 Da
References
  1. Hegde ML, Hegde PM, Holthauzen LM, Hazra TK, Rao KS, Mitra S: Specific Inhibition of NEIL-initiated repair of oxidized base damage in human genome by copper and iron: potential etiological linkage to neurodegenerative diseases. J Biol Chem. 2010 Sep 10;285(37):28812-25. doi: 10.1074/jbc.M110.126664. Epub 2010 Jul 9. [PubMed:20622253]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Microtubule binding
Specific Function
Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that...
Gene Name
POLB
Uniprot ID
P06746
Uniprot Name
DNA polymerase beta
Molecular Weight
38177.34 Da
References
  1. Hegde ML, Hegde PM, Holthauzen LM, Hazra TK, Rao KS, Mitra S: Specific Inhibition of NEIL-initiated repair of oxidized base damage in human genome by copper and iron: potential etiological linkage to neurodegenerative diseases. J Biol Chem. 2010 Sep 10;285(37):28812-25. doi: 10.1074/jbc.M110.126664. Epub 2010 Jul 9. [PubMed:20622253]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Ferroxidase activity
Specific Function
Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iro...
Gene Name
CP
Uniprot ID
P00450
Uniprot Name
Ceruloplasmin
Molecular Weight
122204.45 Da
References
  1. Ha-Duong NT, Eid C, Hemadi M, El Hage Chahine JM: In vitro interaction between ceruloplasmin and human serum transferrin. Biochemistry. 2010 Dec 7;49(48):10261-3. doi: 10.1021/bi1014503. Epub 2010 Nov 9. [PubMed:21049900]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Transferrin receptor binding
Specific Function
Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from si...
Gene Name
TF
Uniprot ID
P02787
Uniprot Name
Serotransferrin
Molecular Weight
77063.195 Da
References
  1. Ha-Duong NT, Eid C, Hemadi M, El Hage Chahine JM: In vitro interaction between ceruloplasmin and human serum transferrin. Biochemistry. 2010 Dec 7;49(48):10261-3. doi: 10.1021/bi1014503. Epub 2010 Nov 9. [PubMed:21049900]

Drug created on August 29, 2007 10:01 / Updated on December 09, 2019 19:25