Identification
NameIron
Accession NumberDB01592
TypeSmall Molecule
GroupsApproved
Description

A metallic element found in certain minerals, in nearly all soils, and in mineral waters. It is an essential constituent of hemoglobin, cytochrome, and other components of respiratory enzyme systems. Its chief functions are in the transport of oxygen to tissue (hemoglobin) and in cellular oxidation mechanisms. Depletion of iron stores may result in iron-deficiency anemia. Iron is used to build up the blood in anemia.

Structure
Thumb
Synonyms
Carbonyl iron
Eisen
Electrolytic iron
Fe
fer
Ferrum
Ferrum metallicum
Hierro
Iron powder
Iron, carbonyl
Iron, electrolytic
Iron, elemental
Iron, reduced
Reduced iron
External IDs Not Available
Product Ingredients
IngredientUNIICASInChI KeyDetails
Ferrous ascorbateDI3477D0PI 24808-52-4RFBYLSCVRUTUSB-ZZMNMWMASA-NDetails
Ferrous fumarateR5L488RY0Q 141-01-5PMVSDNDAUGGCCE-TYYBGVCCSA-LDetails
Ferrous gluconate781E2AXH0K 299-29-6QDUZQOIJXPPTLY-GMBKLUGCSA-NDetails
Ferrous glycine sulfate56PS9HY5XI 14729-84-1YJYOLOWXCPIBSY-UHFFFAOYSA-LDetails
Ferrous succinate818ZYK7N91 10030-90-7MDXRFOWKIZPNTA-UHFFFAOYSA-NDetails
Ferrous sulfate2IDP3X9OUD 7720-78-7BAUYGSIQEAFULO-UHFFFAOYSA-LDetails
Ferrous sulfate dihydrateG0Z5449449 10028-21-4KFJBRJOPXNCARV-UHFFFAOYSA-LDetails
Product Images
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
DexironLiquid50 mgIntramuscular; IntravenousLuitpold Pharmaceuticals1996-09-06Not applicableCanada
InfuferLiquid50 mgIntramuscular; IntravenousSandoz Canada Incorporated1997-02-072016-12-01Canada
VenoferLiquid20 mgIntravenousLuitpold Pharmaceuticals2001-06-05Not applicableCanada
Approved Generic Prescription ProductsNot Available
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Ascofer Cap 275mgCapsule33 mgOralDesbergers LtÉe, Division Of Technilab Inc.1974-12-311999-09-17Canada
Chelated Iron 25mg - CapletTablet25 mgOralHealth Wise Nutrition Inc.1995-12-312002-07-18Canada
Chelated Iron Supplement - TabTablet18 mgOralAlbion1996-09-062002-09-30Canada
Fe-chelate TabTablet28 mgOralNutri West Products Ltd.1994-12-311997-08-05Canada
Fera Liq 16.7mg/15mlLiquid16.7 mgOralInno Vite Incorporated1987-12-312007-07-31Canada
Ferinsol DropsSolution / drops125 mgOralMead Johnson Nutritionals1951-12-311996-09-30Canada
Ferion TabTablet65 mgOralPharmetics (2011) Inc.1981-12-312000-08-21Canada
Fero Grad FilmtabTablet, extended release105 mgOralAbbott1961-12-312008-06-06Canada
Ferrous Fumarate Sct Tab 300mgTablet300 mgOralPharmetics (2011) Inc.1978-12-312000-08-21Canada
Ferrous Fumarate Tab 200mgTablet200 mgOralShoppers Drug Mart Inc.1977-12-311998-08-14Canada
Ferrous GluconateTablet35 mgOralWn Pharmaceuticals Ltd.2002-05-312007-08-07Canada
Ferrous Gluconate Tab 300mgTablet300 mgOralShoppers Drug Mart Inc.1977-12-311997-08-15Canada
Ferrous Gluconate Tab 300mgTablet300 mgOralVita Health Products Inc1957-12-312005-07-20Canada
Ferrous Gluconate Tab 300mgTablet300 mgOralPharmetics (2011) Inc.1973-12-312000-08-21Canada
Ferrous Gluconate Tablet 300mgTablet300 mgOralD.C. Labs Limited1969-12-312005-07-19Canada
Ferrous Sulfate Ect 300mgTablet, delayed release300 mgOralBionatal Drug Co1977-12-311999-07-14Canada
Ferrous Sulfate Tab 300mgTablet, delayed release300 mgOralShoppers Drug Mart Inc.1980-12-311998-08-14Canada
Ferrous Sulfate Tab 300mgTablet, delayed release300 mgOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1957-12-312002-07-31Canada
Ferrous Sulfate Tab 325mg USPTablet325 mgOralPharmavite1991-12-312000-08-24Canada
Ferrous Sulfate Tablets 300mgTablet300 mgOralPharmadex Laboratories Inc.1993-12-311999-08-28Canada
Ferrous SulphateTablet35 mgOralWn Pharmaceuticals Ltd.2002-05-312007-08-07Canada
Fertinic Syr 35mg/5mlSyrup35 mgOralDesbergers LtÉe, Division Of Technilab Inc.1973-12-312000-09-06Canada
Fertinic Tab 300mgTablet300 mgOralDesbergers LtÉe, Division Of Technilab Inc.1939-12-311999-09-17Canada
Gnc Timed Release Womens Iron Fmla-src 30mgCapsule, extended release30 mgOralGeneral Nutrition Canada Inc.2001-10-202005-08-05Canada
IronCapsule40 mgOralSeroyal International Inc.1994-12-312008-10-09Canada
Iron 30mg TabletsTablet30 mgOralBioforce Canada Inc.1994-12-311997-04-14Canada
Iron 35mg Sustained Release Dietary SupplementTablet, extended release35 mgOralGarden State Nutritionals1998-09-222000-06-07Canada
Iron Amino Chelate Tab 37mgTablet37 mgOralPure Life International Prods Inc.1992-12-312000-07-27Canada
Iron Ascorbate CapsCapsule50 mgOralFinlandia Consultants1990-12-311997-12-02Canada
Iron Cap 50mg Time ReleaseTablet, extended release50 mgOralSwiss Herbal Remedies Ltd.1981-12-311998-07-15Canada
Iron Chelate 25 mgTablet25 mgOralWn Pharmaceuticals Ltd.2002-03-132006-08-08Canada
Iron Dietary SupplementTablet35 mgOralGarden State Nutritionals1998-09-222000-06-07Canada
Iron TabTablet18 mgOralShaklee Corporation1982-12-312001-04-01Canada
Kids Chewable IronTablet6 mgOralQuixtar Canada Corporation2001-06-242004-06-22Canada
Novo-ferrosulfa Ect 300mgTablet, delayed release300 mgOralNovopharm Limited1966-12-311996-09-10Canada
Novo-ferrosulfa Tab 300mg(fct)Tablet300 mgOralNovopharm Limited1991-12-311996-09-10Canada
Novo-fumar 200mgTablet200 mgOralNovopharm Limited1967-12-312005-08-10Canada
Scheinpharm Ferrous Fumarate - 300mgCapsule100 mgOralSchein Pharmaceutical Canada Inc.1997-05-272004-07-26Canada
Sulfate Ferreux 300mg TabTablet, delayed release60 mgOralPro Doc Limitee1982-12-312009-07-23Canada
Timed Release Iron 35mgTablet, extended release35 mgOralNutricorp International1999-11-302009-08-05Canada
Timed Release Iron 50mgTablet, extended release50 mgOralNutricorp International2003-09-302009-08-06Canada
Timed Release Iron 50mg TabletsTablet, extended release50 mgOralSwiss Herbal Remedies Ltd.1998-01-262008-08-15Canada
Usana Iron 28 SupplementTablet28 mgOralUsana Health Sciences, Inc.1999-09-302001-07-18Canada
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Ferrous SulfateTablet, film coated325 mg/1OralCentral Texas Community Health Centers2014-07-01Not applicableUs
Ferrous SulfateElixir220 mg/5mLOralLLC Federal Solutions2013-08-12Not applicableUs
Ferrous SulfateTablet325 mg/1OralState of Florida DOH Central Pharmacy2014-01-01Not applicableUs
Ferrous SulfateTablet325 mg/1OralA S Medication Solutions2001-02-192017-06-20Us
Ferrous SulfateTablet325 mg/1OralQualitest2001-02-192020-03-30Us
Ferrous SulfateTablet, film coated325 mg/1OralSun Pharmaceutical Industries Limited2014-07-01Not applicableUs
Ferrous SulfateTablet325 mg/1OralA S Medication Solutions2001-02-192017-06-20Us
Ferrous SulfateTablet325 mg/1OralUnit Dose Services2001-02-19Not applicableUs
Ferrous SulfateTablet, film coated325 mg/1OralPreferreed Pharmaceuticals Inc.2017-05-18Not applicableUs
Ferrous SulfateTablet325 mg/1OralRichmond Pharmaceuticals2008-11-05Not applicableUs
Ferrous SulfateElixir220 mg/5mLOralRij Pharmaceutical Corporation1999-03-16Not applicableUs
Ferrous SulfateTablet325 mg/1OralA S Medication Solutions2001-02-192017-06-20Us
Ferrous SulfateTablet65 mg/1OralBoca Pharmacal, Inc.2010-09-142018-06-30Us
Ferrous SulfateTablet325 mg/1Oralbryant ranch prepack2001-02-19Not applicableUs
Ferrous SulfateTablet, film coated325 mg/1OralSun Pharmaceutical Industries Limited2014-07-01Not applicableUs
Iferex 150Capsule150 mg/1OralNnodum Pharmaceuticals2007-10-28Not applicableUs
Iron ChewsTablet, chewable15 mg/1OralMidlothian Laboratories2009-01-01Not applicableUs
Polysaccharide-IronCapsule150 mg/1OralAdvance Pharmaceutical Inc.2015-05-26Not applicableUs
International Brands
NameCompany
Ed-In-SolNot Available
Fe-40Not Available
FeosolGlaxoSmithkline
FeostatNot Available
Fer-In-SolNot Available
FeratabUpsher-Smith
FerateNot Available
FergonNot Available
FerraletNot Available
FerrettsNot Available
Ferro sanolNot Available
Ferro-CapsNot Available
Ferro-TimeNot Available
FerrousalNot Available
SiderolNot Available
SimronNot Available
Slow FeNot Available
Vitedyn-SloNot Available
YieroniaNot Available
Brand mixtures
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Active FETabletOralGm Pharmaceuticals2013-11-11Not applicableUs
ActyformCapsuleOralTechnodiet S.E.N.C.1999-10-262008-08-13Canada
Alsimine W Vitamins A DCapsule; LiquidOralAlsi Cie Ltee1978-12-312003-05-21Canada
AppedrineTabletOralChattem, Inc.1975-12-312004-07-08Canada
Aurovela 24 FeKitAurobindo Pharma2017-06-15Not applicableUs
Aurovela Fe 1/20KitAurobindo Pharma2017-06-16Not applicableUs
B Stress C + Iron & ViteTabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1990-12-312004-07-26Canada
BacminTablet, coatedOralMarnel Pharmaceuticals, Llc2000-04-01Not applicableUs
Bev 29 TabTabletOralBeverly International Nutrition1987-12-311998-08-01Canada
BioFerr 90Tablet, film coatedOralBiocomp Pharma, Inc.2014-07-01Not applicableUs
Bugs Bunny Chew Multi Vit Plus IronTabletOralMiles Inc. Pharmaceutical Division1983-12-311996-09-09Canada
C-Nate DHACapsule, gelatin coatedOralCenturion Labs2013-01-01Not applicableUs
Calcium Et Magnesium Plus Vitamine D/fe/znTabletOralLaboratoire Lalco Inc.1993-12-312008-07-29Canada
Calcium Vitamin D Iron MagTabletOralLaboratoire Lalco Inc.1993-12-312008-07-29Canada
Central-vite 18 EssentialTabletOralVita Health Products Inc1998-04-242002-07-31Canada
Century CompleteTabletOralVita Health Products Inc1998-03-172002-07-31Canada
Chewable Multiple Vit Plus Iron for ChildrenTabletOralRandle Pharmaceutical Inc.1996-09-191999-09-03Canada
Chewable Multiple Vitamins Plus Iron TabTabletOralRandle Pharmaceutical Inc.1993-12-311999-09-03Canada
Chewable Multivitamins Plus IronTabletOralWn Pharmaceuticals Ltd.2002-05-312007-08-07Canada
Children Choice Multivitamin W Iron Chew TabTabletOralSwiss Herbal Remedies Ltd.1991-12-312009-08-04Canada
Children's Chewable Multi Vit W IronTabletOralShoppers Drug Mart Inc.1982-12-311997-08-15Canada
Children's Chewable Multi Vitamins With Iron TabletsTabletOralVita Health Products Inc1998-05-202008-08-05Canada
Children's Chewable Multi-vitamin Complete With MineralsTabletOralWn Pharmaceuticals Ltd.2000-03-012001-07-18Canada
Children's Chewable Multiple Vit.plus IronTabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1997-10-102002-07-31Canada
Children's Chewable Multiple Vitamins With Iron Tablets (chewable Tablets)TabletOralPharmetics (2011) Inc.1999-08-162009-07-30Canada
Children's Vitamins W Iron ChewableTabletOralVita Health Products Inc1990-12-312002-07-31Canada
Childrens Chewable Multiple Vitamins Plus FeTabletOralKsl Pharmaceuticals1994-12-312000-08-29Canada
Childrens Chewable Multivitamins W IronTabletOralRandle Pharmaceutical Inc.1987-12-311997-05-30Canada
Childrens Multiple Vit and Min Chew TabTabletOralCountry Health Laboratories Ltd.1982-12-312008-07-17Canada
ChromagenCapsuleOralAvion Pharmaceuticals, Llc2017-01-23Not applicableUs
CitraNatal B-CalmKitMission Pharmacal2010-02-10Not applicableUs
CitraNatal BloomTablet, film coatedOralMission Pharmacal2017-08-01Not applicableUs
CitraNatal DHATabletOralMission Pharmacal2007-11-20Not applicableUs
Citranatal Harmony 2.1Capsule, gelatin coatedOralMission Pharmacal2013-01-21Not applicableUs
CitraNatal Harmony 3.0Capsule, gelatin coatedOralMission Pharmacal2014-03-21Not applicableUs
CitraNatal RxTabletOralMission Pharmacal2014-08-11Not applicableUs
Complete Multivitamins and Minerals for ChildrenTabletOralQuest Vitamins A Div Of Purity Life Health Products2001-01-312004-06-29Canada
Complete Multivitamins and Minerals Tablets Timed ReleaseTablet, extended releaseOralPharmetics (2011) Inc.1999-07-262009-07-30Canada
Concept DHACapsule, liquid filledOralUs Pharmaceutical Corporation2009-06-24Not applicableUs
Concept OBCapsuleOralUs Pharmaceutical Corporation2009-01-01Not applicableUs
Copper 3mg Plus Iron & Zinc TabTabletOralSwiss Herbal Remedies Ltd.1986-12-312000-08-03Canada
Dexatrim TabletsTabletOralChattem, Inc.1996-09-092005-06-29Canada
Dynam Ampoule Et TabletLiquid; TabletOralCardinaux Enrg Les Produits Naturels1989-12-311996-09-09Canada
EscaviteTablet, chewableOralGm Pharmaceuticals2012-02-01Not applicableUs
Everyday Multiple Vitamins With IronTabletOralD.C. Labs Limited1972-12-312003-07-11Canada
Exact-Rx SODIUM SULFACETAMIDE and SULFER 10%/5% CleanserLotionTopicalExact Rx, Inc.2011-08-012017-02-07Us
Extra-Virt Plus DHACapsule, gelatin coatedOralVirtus Pharmaceuticals2012-12-28Not applicableUs
FE C TabTabletOralBoca Pharmacal, Inc.2010-08-192017-11-30Us
FE C Tab PlusTabletOralBoca Pharmacal, Inc.2011-03-312015-12-29Us
Fem - ControlTabletOralMetagenics, Inc.1998-01-312005-08-19Canada
Feminex 300 TabTabletOralSantÉ Naturelle (Ag) LtÉe1986-12-311997-09-09Canada
Feminique W Iron and Calcium TabTabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1992-12-311998-08-13Canada
Femitab TabTabletOralLe Groupe Prodeal Ltee1988-12-312009-08-05Canada
FeRiva FACapsule, gelatin coatedOralAvion Pharmaceuticals, Llc2014-12-18Not applicableUs
Fero Grad 500Tablet, extended releaseOralAbbott1961-12-311999-08-09Canada
Ferra Naka Plus VitaminsLiquidOralNaka Sales Ltd.1999-05-052001-07-23Canada
Ferralet 90Tablet, film coatedOralMission Pharmacal2010-02-042017-08-24Us
Ferrous SulfateTabletOralMartin Ekwealor Pharmaceuticals, Inc.2014-09-01Not applicableUs
Fib-C MeltsTabletOralApm Products Pty Ltd.2003-08-152004-09-10Canada
Flinstones Multiple Plus IronTabletOralMiles Inc. Pharmaceutical Division1971-12-311996-09-09Canada
Flintstones Multiple Vitamins Plus IronTabletOralBayer Inc Consumer Care1995-12-312004-06-28Canada
Floradix Formula LiqLiquidOralFlora Manufacturing And Distributing Ltd.1979-12-312002-06-05Canada
Floravit - SyrSyrupOralFlora Manufacturing And Distributing Ltd.1995-05-282009-08-05Canada
Folcal DHACapsule, gelatin coatedOralMidlothian Laboratories2010-12-01Not applicableUs
Folcaps Care OneCapsule, gelatin coatedOralMidlothian Laboratories2009-05-01Not applicableUs
Folcaps Omega-3Capsule, gelatin coatedOralMidlothian Laboratories2011-01-03Not applicableUs
Folet OneCapsule, liquid filledOralPronova Corporation2014-06-01Not applicableUs
Folivane-PRx DHACapsuleOralTrigen Laboratories, Inc.2010-01-01Not applicableUs
Foltabs PrenatalTabletOralMidlothian Laboratories2009-01-01Not applicableUs
For Kids Only Chewable Multivit. Plus IronTabletOralKsl Pharmaceuticals1996-12-312002-07-31Canada
Formula Fm Vitamins & Minerals TabTabletOralMetagenics, Inc.1997-01-272001-10-05Canada
Formula IntCapsuleOralBalance Plus, Inc.2000-02-092004-08-17Canada
Formule No 204 Profil TabTabletOralPharmalab Inc.1987-12-312001-07-30Canada
FortiplexTabletOralSantÉ Naturelle (Ag) LtÉe1984-12-312001-07-06Canada
Garfield Chewable Multivits Plus Iron TabTabletOralWhitehall Robins Inc.1993-12-312000-07-26Canada
Gestamine ComprimesTabletOralLab Nadeau LtÉe, Division Of Technilab Inc.1957-12-311999-09-28Canada
Gesticare DHAKitJazz Pharmaceuticals Commercial Corp.2008-10-01Not applicableUs
Hemarexin TabTabletOralLab Bio Chimique Inc.,Division Of Technilab Pharma Inc.1997-12-172004-08-03Canada
HematogenCapsuleOralNnodum Pharmaceuticals2007-05-10Not applicableUs63044 0631 19 nlmimage10 23409194
Hematogen FACapsuleOralNnodum Pharmaceuticals2005-01-01Not applicableUs
Hematogen ForteCapsule, gelatin coatedOralNnodum Pharmaceuticals2007-05-10Not applicableUs
Heparos Ampoules BuvablesLiquidOralDesbergers LtÉe, Division Of Technilab Inc.1987-12-311999-09-17Canada
Hi Potency B Complex W Chelated MineralsTabletOralKlaire Labs Inc.1984-12-312004-01-19Canada
Hormodausse Plus Calc Et D TabTabletOralLaboratoires Charton Laboratories1988-12-311999-01-16Canada
Hypo Vites TabTabletOralPharmetics (2011) Inc.1977-12-312006-07-27Canada
Iberet 500Tablet, extended releaseOralAbbott1965-12-312007-07-31Canada
Iferex 150 ForteCapsuleOralNnodum Pharmaceuticals2007-10-28Not applicableUs
Inatal AdvanceTablet, coatedOralNnodum Pharmaceuticals2005-06-10Not applicableUs
INATAL UltraTablet, coatedOralNnodum Pharmaceuticals2005-06-20Not applicableUs
Integra FCapsuleOralUs Pharmaceutical Corporation2009-04-27Not applicableUs
Integra PlusCapsuleOralUs Pharmaceutical Corporation2009-04-27Not applicableUs
Iron 25mg With Vit B-cmplx, Vit C, Cu & MoCapsuleOralQuest Vitamins A Div Of Purity Life Health Products1996-07-232002-07-29Canada
Iron ComplexTabletOralPremier Plus Supplements Inc.2000-04-252003-07-16Canada
Iron IITabletOralNutrilite, A Division Of Access Business Group, Llc1983-12-311996-09-09Canada
Iron Plus Manganese, B12, Folic Acid & CTabletOralNatural Factors Nutritional Products Ltd.1988-12-312005-08-15Canada
Iron Plus TabTabletOralSwiss Herbal Remedies Ltd.1973-12-312008-08-15Canada
Iron Vitamins B6,b12,c,folic Acid TabTabletOralLaboratoire Lalco Inc.1989-12-311997-07-31Canada
Iron W Zinc Chelated W Liver TabTabletOralTrophic Canada Ltd.1977-12-311999-08-12Canada
Iron With Vitamins TabTabletOralEnrich International1994-12-312001-09-28Canada
Junel Fe 24KitTeva2015-05-29Not applicableUs00093 5328 62 nlmimage10 f642fb77
Kanga-kid Multi-vitamin & MineralTablet, effervescentOralLacombe Drugs (1992) LtdNot applicableNot applicableCanada
Kanga-kid Vitamins & IronTablet, effervescentOralLacombe Drugs (1992) LtdNot applicableNot applicableCanada
Kanga-V Multivitamins & MineralsTablet, effervescentOralLacombe Drugs (1992) LtdNot applicableNot applicableCanada
Kids Stuff With Iron TabletsTabletOralVita Health Products Inc1998-04-202002-07-31Canada
Livron Plus AmpouleLiquidOralMedic Laboratory LtÉe1980-12-311996-09-09Canada
Lysamine Diet Supp Amp-tabLiquid; TabletOralWelcker Lyster Ltd., Division Of Technilab Inc.1983-12-311999-09-17Canada
Maltlevol 12 LiqLiquidOralCarter Horner Corp.1978-12-312002-02-07Canada
Maltlevol LiqLiquidOralCarter Horner Corp.1980-12-312005-03-21Canada
Maxaron ForteCapsuleOralCentrix Pharmaceutical2007-12-012016-12-02Us
MaxFeTabletOralPronova Corporation2014-06-01Not applicableUs
Menocal TabTabletOralLes Aliments Nutri Source Inc.1994-12-312009-08-05Canada
MgkCapsuleOralHorizon SantÉ International Inc.Not applicableNot applicableCanada
Mor-vites TabTabletOralPharmetics (2011) Inc.1992-12-312006-07-27Canada
Multi RolLiquid; TabletOralRolmex International Inc.1975-12-311997-08-08Canada
Multi Vitamin - MineralTabletOralEnrich International1999-11-112001-09-28Canada
Multi Vitamin & MineralsTabletOralWn Pharmaceuticals Ltd.2002-01-042008-07-17Canada
Multi Vitamin Drops with Fluoride and IronSolution / dropsOralSeton Pharmaceuticals2014-04-18Not applicableUs
Multi Vitamin Drops with Fluoride with IronLiquidOralStratus Pharmaceuticals2014-09-01Not applicableUs
Multi Vitamin Plus IronTabletOralWn Pharmaceuticals Ltd.2002-03-132009-09-28Canada
Multi Vitamin-mineral FormulaTabletOralVita Health Products Inc1997-04-031998-01-16Canada
Multi Vitamin, Iron and FluorideSolution / dropsOralMayne Pharma2011-05-212019-10-31Us
Multi Vitamins & MineralsTabletOralWn Pharmaceuticals Ltd.2000-01-122001-04-12Canada
Multi-Vit with Fluoride and IronSolutionOralQualitest1998-01-07Not applicableUs
Multi-Vitamin Drops with Fluoride and IronLiquidOralMethod Pharmaceuticals2017-02-24Not applicableUs
Multi-Vitamin Fluoride and Iron DropsSolutionOralBoca Pharmacal, Inc.2011-04-202015-12-29Us
Multi-vitamins With MineralsTabletOralWn Pharmaceuticals Ltd.2001-04-122009-09-28Canada
Multimineral ChelatesTabletOralW.R. Enterprises Inc.1984-12-312002-08-01Canada
Multiple Vitamin Plus Minerals TabTabletOralHall Laboratories, Ltd.1981-12-312003-09-11Canada
Multiple Vitamins & Minerals TabletsTabletOralPharmetics (2011) Inc.2002-12-182006-07-27Canada
Multiple Vitamins and Minerals TabTabletOralRandle Pharmaceutical Inc.1987-12-311997-05-30Canada
Multiple Vitamins Plus Iron for WomenTabletOralPharmetics (2011) Inc.1999-08-162006-07-27Canada
Multiple Vitamins Plus Iron TabTabletOralHall Laboratories, Ltd.1981-12-312003-09-11Canada
Multiple Vitamins W Minerals TabTabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1976-12-312002-07-31Canada
Multiple Vitamins With IronTabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1987-12-312002-07-31Canada
Multiple Vitamins With Minerals TabletsTabletOralPharmetics (2011) Inc.1999-07-162009-07-30Canada
Multivit Et Fer Ampoules Et ComprimesLiquid; TabletOralNobel Pharm Enr.1988-12-311998-08-14Canada
Multivitamines Et MinerauxTabletOralLe Groupe M. Vachon Inc.Not applicableNot applicableCanada
Multivitamines Et Mineraux Reguliers / Regular Multivitamins and MineralsTabletOralVita Health Products Inc1998-10-062004-07-26Canada
Multivitamines Plus Fer Pour Enfants (chewable Tablets)TabletOralLaboratoire Lalco Inc.1998-07-032002-09-05Canada
Multivitamins and Minerals - CompleteTabletOralVita Health Products Inc2000-02-012006-07-31Canada
Multivitamins and Multiminerals Formula Regular TabletTabletOralPharmetics (2011) Inc.2001-11-222009-07-30Canada
Multivitamins W IronTabletOralRandle Pharmaceutical Inc.1987-12-311997-05-30Canada
Nata KompleteTabletOralWh Nutritionals, Llc2011-06-252016-12-06Us
NataFortTabletOralMission Pharmacal2011-08-25Not applicableUs
NataviteTabletOralSchein Pharmaceutical Canada Inc.1997-07-292004-07-26Canada
Natelle OneCapsule, gelatin coatedOralMeda Pharmaceuticals Ltd2015-02-01Not applicableUs
Neo-vites & Minerals TabTabletOralNeolab Inc1987-12-311997-08-12Canada
Nestabs ONECapsule, gelatin coatedOralWomens Choice Pharmaceuticals, Llc2017-07-20Not applicableUs
Nexa PlusCapsuleOralUpsher Smith Laboratories2012-08-01Not applicableUs
Nexa Select Rx Prenatal Vitamin with Plant-Based DHACapsuleOralUpsher Smith Laboratories2012-12-17Not applicableUs
Nexesta FeKitAurobindo Pharma2017-02-02Not applicableUs
Niron KompleteTabletOralWh Nutritionals, Llc2011-06-252016-12-06Us
Norethindrone Acetate and Ethinyl Estradiol and Ferrous FumarateKitAurobindo Pharma2017-06-15Not applicableUs
NuFeraTabletOralCarwin Associates, Inc2015-12-16Not applicableUs
Nutrifer Plus TabletsTabletOralWyeth Ayerst Canada Inc.1994-12-311999-09-23Canada
O-Cal FA multivitaminTabletOralPharmics, Inc.1970-01-15Not applicableUs
O-Cal Prenatal VitaminTabletOralPharmics, Inc.2002-01-23Not applicableUs
One A Day Advance AdultsTabletOralBayer Inc Consumer Care2002-09-122007-08-02Canada
One A Day Advance FemTabletOralBayer Inc Consumer Care1999-03-012001-02-22Canada
One A Day TabTabletOralCountry Health Laboratories Ltd.1982-12-312001-07-27Canada
Orange Flavored Crystal Chews TabTabletOralJeunique International Inc.1998-02-172006-07-20Canada
Orifer FTabletOralSanofi Aventis1995-12-312007-11-22Canada
Paramettes Chewable Multivitamins Plus IronTabletOralWyeth Ayerst Canada Inc.1994-12-312000-08-02Canada
Paramettes Chewable Multivits With Iron TabTabletOralWhitehall Robins Inc.1994-12-311996-09-09Canada
Paramettes Multivits Plus Iron Tab (teens)TabletOralWhitehall Robins Inc.1993-12-311996-09-09Canada
Paramettes SyrupSyrupOralWyeth Ayerst Canada Inc.1994-12-312002-07-31Canada
Permathene-12 - CapletTabletOralCca Industries, Inc1995-12-312000-12-14Canada
Phosthenine Vitamines Et Fer (ampoules Buvable)LiquidOralLaboratoires Cortunon Inc.1997-01-232007-07-23Canada
Phytofortis + Calcium A-DLiquid; TabletOralPhyto Health Corporation1983-12-312003-11-27Canada
PhytopureCapsuleOralLaboratoire Lalco Inc.1993-12-312001-10-15Canada
PNV Ferrous Fumarate Docusate Folic AcidTabletOralVirtus Pharmaceuticals2014-04-22Not applicableUs
PNV Prenatal Plus MultivitaminTabletOralClinical Solutions Wholsesale2013-04-012017-07-03Us
PNV Prenatal VitaminTablet, chewableOralSancilio & Company Inc.2011-12-20Not applicableUs
PNV Prenatal Vitamin Plus Vitamin ATabletOralSancilio & Company Inc.2012-12-07Not applicableUs
Pnv-dhaCapsule, gelatin coatedOralAcella Pharmaceuticals, LLC2009-11-02Not applicableUs
PNV-SelectTablet, film coatedOralAcella Pharmaceuticals, LLC2009-11-02Not applicableUs
PregvitTabletOralDuchesnay Inc.2003-08-252016-07-05Canada
Pregvit Folic 4TabletOralDuchesnay Inc.Not applicableNot applicableCanada
Pregvit Folic 5TabletOralDuchesnay Inc.2006-03-172016-07-05Canada
PrenaissanceCapsule, liquid filledOralAcella Pharmaceuticals, LLC2011-05-192017-09-08Us
Prenaissance PlusCapsule, liquid filledOralAcella Pharmaceuticals, LLC2011-09-12Not applicableUs
PreNatal 19Tablet, coatedOralNationwide Laboratories2013-06-01Not applicableUs
Prenatal Chelated MineralTabletOralUsana Health Sciences, Inc.2012-04-11Not applicableUs
Prenatal PlusTablet, film coatedOralBlenheim Pharmacal, Inc.2010-12-09Not applicableUs65162 0668 50 nlmimage10 120e0910
Prenatal Plus IronTablet, film coatedOralMajor2011-06-07Not applicableUs
PreNatal Vitamins PlusTabletOralbryant ranch prepack2011-04-15Not applicableUs
Prenatal Vitamins Plus Low IronTabletOralPatrin Pharma2013-04-01Not applicableUs39328 0106 10 nlmimage10 df476fdb
Prenatal, DHAKitPure Tek Corporation2017-08-10Not applicableUs
Prenate EliteTablet, coatedOralAvion Pharmaceuticals, Llc2012-08-06Not applicableUs
PRENATE EnhanceCapsule, gelatin coatedOralAvion Pharmaceuticals, Llc2013-09-17Not applicableUs
PRENATE RestoreCapsule, gelatin coatedOralAvion Pharmaceuticals, Llc2013-09-17Not applicableUs
Prenavite ForteTabletOralAllen & Hanburys A Glaxo Canada Ltd. Co.1986-12-311996-09-10Canada
Prenavite Forte TabletsTabletOralRoberts Pharmaceutical1995-12-311999-08-11Canada
Prenavite TabletsTabletOralRoberts Pharmaceutical1995-12-311999-08-11Canada
PreNexaCapsule, gelatin coatedOralUpsher Smith Laboratories2010-05-25Not applicableUs
PrePLUSTabletOralVirtus Pharmaceuticals2014-04-04Not applicableUs
PreQue 10TabletOralActavis Pharma Company2011-11-01Not applicableUs
PreTABTabletOralVirtus Pharmaceuticals2014-04-092017-08-08Us
Prevencal 600 + D Et FerTabletOralLaboratoire Lalco Inc.1987-12-311997-07-31Canada
PureVit DualFe PlusCapsuleOralPure Tek Corporation2011-06-01Not applicableUs
Q.T. Vitamin and Mineral Drink MixPowderOralGarden State NutritionalsNot applicableNot applicableCanada
Reaphirm Plant Source DHACapsule, gelatin coatedOralEverett Laboratories, Inc.2011-12-05Not applicableUs
Revitex Ampoules Et ComprimesLiquid; TabletOralLes Produits Gerbex Inc.1988-12-312005-06-29Canada
Revival 1 TabTabletOralBio Vita1991-12-311999-08-12Canada
Se-Care ChewableTablet, chewableOralSeton Pharmaceuticals2009-05-012016-10-13Us
Se-Natal 19TabletOralSeton Pharmaceuticals2009-07-01Not applicableUs
Se-Natal 19 ChewableTablet, chewableOralSeton Pharmaceuticals2009-07-01Not applicableUs
Se-Natal OneTabletOralSeton Pharmaceuticals2009-04-162016-10-13Us
Se-Tan DHACapsule, gelatin coatedOralSeton Pharmaceuticals2009-10-012016-04-30Us
Se-Tan PLUSCapsule, gelatin coatedOralSeton Pharmaceuticals2009-10-01Not applicableUs
Somarexin and C 1000Liquid; TabletOralLaboratoire Lalco Inc.1977-12-312008-07-29Canada
Spectrum 2 CapCapsuleOralNf Formulas Inc.1988-12-312008-06-26Canada
Stom #2CapsuleOralMorinda Canada1999-12-202001-07-23Canada
Stress B Complex With C, E & IronTabletOralPharmavite1999-10-312005-07-15Canada
Stress Formula + IronTabletOralVita Health Products Inc1998-05-202006-07-31Canada
Strovite Forte CapletTablet, coatedOralEverett Laboratories, Inc.1996-10-01Not applicableUs
Super Daily No 2TabletOralW.R. Enterprises Inc.1990-12-312003-07-30Canada
Super Vitalex Ampoule BuvableLiquidOralCarmaran LtÉe1984-12-312001-08-31Canada
Supplement De FerLiquidOralLand Art Inc.1997-03-101999-08-02Canada
Supravite 10ml AmpouleLiquidOralNobel Pharm Enr.1991-12-312002-09-06Canada
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Supravite Stress Avec Vit E Et FerTabletOralPharmalab Inc.1985-12-311997-08-08Canada
Surbex-500 With IronTabletOralAbbott1986-12-312008-06-06Canada
Swical-energy-2LiquidOralLes Laboratoires Swisse Inc.1997-06-092006-02-14Canada
TandemCapsuleOralUs Pharmaceutical Corporation2006-02-17Not applicableUs
Tandem - FCapsuleOralUs Pharmaceutical Corporation2006-06-17Not applicableUs
Tandem DHACapsuleOralUs Pharmaceutical Corporation2007-01-17Not applicableUs
Tandem OBCapsuleOralUs Pharmaceutical Corporation2006-06-17Not applicableUs
Tandem PlusCapsuleOralUs Pharmaceutical Corporation2006-06-17Not applicableUs
Tini-cal AmpoulesLiquidOralPharmetics (2011) Inc.1966-12-312001-07-26Canada
Tl-hem 150Tablet, film coatedOralTrigen Laboratories, Inc.2011-01-01Not applicableUs
Toni Com LiqLiquidOralVitalab1990-12-312009-07-14Canada
Tonicol Et A-D-C Ampoules/comprimesLiquid; TabletOralDistributions Multi Pro Inc.1988-12-311999-07-21Canada
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Tricare PrenatalTablet, coatedOralMedecor Pharma, Llc2002-11-11Not applicableUs
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Trinatal GTTabletOralTrigen Laboratories, Inc.2011-07-052017-09-13Us
Triveen-PRx RNFCapsuleOralTrigen Laboratories, Inc.2010-05-152017-09-16Us
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Vimeral TabTabletOralIcn Pharmaceuticals1979-12-312005-04-26Canada
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Virt-Pn DHACapsule, gelatin coatedOralVirtus Pharmaceuticals2012-07-122017-08-08Us
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Vita Day TabTabletOralJamieson Laboratories Ltd1993-12-311997-08-13Canada
Vitafer - LiqLiquidOralFrega Inc.1995-12-311997-12-10Canada
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Vitafol PlusCapsule, liquid filledOralEverett Laboratories, Inc.2012-04-23Not applicableUs
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Vitamine Du Groupe B Plus Fer - LiqLiquidOralPharmalab Inc.1995-12-312008-07-14Canada
Vitogen Multiple Vitamins W IronTabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1976-12-311997-10-14Canada
Vitreat Chewable Vitamins Plus IronTabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1977-12-311997-08-08Canada
VP CH PlusCapsule, gelatin coatedOralVirtus Pharmaceuticals2014-04-092017-09-05Us
VP CH UltraCapsule, gelatin coatedOralVirtus Pharmaceuticals2014-04-142017-08-08Us
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Women's FormulaTabletOralWn Pharmaceuticals Ltd.2002-04-252009-09-28Canada
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Categories
UNIIE1UOL152H7
CAS number7439-89-6
WeightAverage: 55.845
Monoisotopic: 55.934942133
Chemical FormulaFe
InChI KeyXEEYBQQBJWHFJM-UHFFFAOYSA-N
InChI
InChI=1S/Fe
IUPAC Name
iron
SMILES
[Fe]
Pharmacology
Indication

Used in preventing and treating iron-deficiency anemia.

Structured Indications
Pharmacodynamics

The major activity of supplemental iron is in the prevention and treatment of iron deficiency anemia. Iron has putative immune-enhancing, anticarcinogenic and cognition-enhancing activities.

Mechanism of action

Iron is necessary for the production of hemoglobin. Iron-deficiency can lead to decreased production of hemoglobin and a microcytic, hypochromic anemia.

TargetKindPharmacological actionActionsOrganismUniProt ID
Transferrin receptor protein 1ProteinunknownNot AvailableHumanP02786 details
Egl nine homolog 1ProteinunknownNot AvailableHumanQ9GZT9 details
Histone deacetylase 8Proteinunknown
cofactor
HumanQ9BY41 details
Alpha-hemoglobin-stabilizing proteinProteinunknownNot AvailableHumanQ9NZD4 details
Hemoglobin subunit alphaProteinunknownNot AvailableHumanP69905 details
Frataxin, mitochondrialProteinunknownNot AvailableHumanQ16595 details
Ferritin heavy chainProteinunknownNot AvailableHumanP02794 details
Flap endonuclease 1ProteinunknownNot AvailableHumanP39748 details
Endonuclease 8-like 1ProteinunknownNot AvailableHumanQ96FI4 details
Endonuclease 8-like 2ProteinunknownNot AvailableHumanQ969S2 details
DNA polymerase betaProteinunknownNot AvailableHumanP06746 details
CeruloplasminProteinunknownNot AvailableHumanP00450 details
SerotransferrinProteinunknownNot AvailableHumanP02787 details
Related Articles
Absorption

The efficiency of absorption depends on the salt form, the amount administered, the dosing regimen and the size of iron stores. Subjects with normal iron stores absorb 10% to 35% of an iron dose. Those who are iron deficient may absorb up to 95% of an iron dose.

Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
Toxicity

Acute iron overdosage can be divided into four stages. In the first stage, which occurs up to six hours after ingestion, the principal symptoms are vomiting and diarrhea. Other symptoms include hypotension, tachycardia and CNS depression ranging from lethargy to coma. The second phase may occur at 6-24 hours after ingestion and is characterized by a temporary remission. In the third phase, gastrointestinal symptoms recur accompanied by shock, metabolic acidosis, coma, hepatic necrosis and jaundice, hypoglycemia, renal failure and pulmonary edema. The fourth phase may occur several weeks after ingestion and is characterized by gastrointestinal obstruction and liver damage. In a young child, 75 milligrams per kilogram is considered extremely dangerous. A dose of 30 milligrams per kilogram can lead to symptoms of toxicity. Estimates of a lethal dosage range from 180 milligrams per kilogram and upwards. A peak serum iron concentration of five micrograms or more per ml is associated with moderate to severe poisoning in many.

Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Tyrosine MetabolismMetabolicSMP00006
Inositol MetabolismMetabolicSMP00011
Taurine and Hypotaurine MetabolismMetabolicSMP00021
Pravastatin Action PathwayDrug actionSMP00089
Risedronate Action PathwayDrug actionSMP00112
MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy)DiseaseSMP00202
HypercholesterolemiaDiseaseSMP00209
Congenital Bile Acid Synthesis Defect Type IIDiseaseSMP00314
Zellweger SyndromeDiseaseSMP00316
Congenital Bile Acid Synthesis Defect Type IIIDiseaseSMP00318
Refsum DiseaseDiseaseSMP00451
Tyrosinemia, transient, of the newbornDiseaseSMP00494
Glucose-6-phosphate dehydrogenase deficiencyDiseaseSMP00518
Ribose-5-phosphate isomerase deficiencyDiseaseSMP00519
Phenylalanine and Tyrosine MetabolismMetabolicSMP00008
Cerivastatin Action PathwayDrug actionSMP00111
Pamidronate Action PathwayDrug actionSMP00117
Atorvastatin Action PathwayDrug actionSMP00131
AlkaptonuriaDiseaseSMP00169
Beta Ureidopropionase DeficiencyDiseaseSMP00172
Dihydropyrimidinase DeficiencyDiseaseSMP00178
HawkinsinuriaDiseaseSMP00190
UMP Synthase Deiciency (Orotic Aciduria)DiseaseSMP00219
Lactose SynthesisMetabolicSMP00444
Phytanic Acid Peroxisomal OxidationMetabolicSMP00450
Dopamine beta-hydroxylase deficiencyDiseaseSMP00498
Cholesteryl ester storage diseaseDiseaseSMP00508
Mevalonic aciduriaDiseaseSMP00510
Monoamine oxidase-a deficiency (MAO-A)DiseaseSMP00533
Congenital disorder of glycosylation CDG-IIdDiseaseSMP00579
Pharmacogenomic Effects/ADRs Not Available
Interactions
Drug Interactions
DrugInteractionDrug group
Aluminum hydroxideAluminum hydroxide can cause a decrease in the absorption of Iron resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
AsenapineAsenapine can cause a decrease in the absorption of Iron resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
BenazeprilThe risk or severity of adverse effects can be increased when Benazepril is combined with Iron.Approved, Investigational
Bismuth SubcitrateBismuth Subcitrate can cause a decrease in the absorption of Iron resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Calcium CarbonateCalcium carbonate can cause a decrease in the absorption of Iron resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
CandoxatrilThe risk or severity of adverse effects can be increased when Candoxatril is combined with Iron.Experimental
CaptoprilThe risk or severity of adverse effects can be increased when Captopril is combined with Iron.Approved
CefdinirThe serum concentration of Cefdinir can be decreased when it is combined with Iron.Approved
ChlortetracyclineChlortetracycline can cause a decrease in the absorption of Iron resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Vet Approved
CilazaprilThe risk or severity of adverse effects can be increased when Cilazapril is combined with Iron.Approved
CimetidineCimetidine can cause a decrease in the absorption of Iron resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
CinoxacinThe serum concentration of Cinoxacin can be decreased when it is combined with Iron.Approved, Withdrawn
CiprofloxacinThe serum concentration of Ciprofloxacin can be decreased when it is combined with Iron.Approved, Investigational
DeferiproneThe serum concentration of Deferiprone can be decreased when it is combined with Iron.Approved
DemeclocyclineDemeclocycline can cause a decrease in the absorption of Iron resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
DexlansoprazoleTAK-390MR can cause a decrease in the absorption of Iron resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
DimercaprolDimercaprol may increase the nephrotoxic activities of Iron.Approved
Dipotassium phosphateIron can cause a decrease in the absorption of Dipotassium phosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
DolutegravirThe serum concentration of Dolutegravir can be decreased when it is combined with Iron.Approved
DoxepinDoxepin can cause a decrease in the absorption of Iron resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
DoxycyclineDoxycycline can cause a decrease in the absorption of Iron resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational, Vet Approved
EltrombopagThe serum concentration of Eltrombopag can be decreased when it is combined with Iron.Approved
EnalaprilThe risk or severity of adverse effects can be increased when Enalapril is combined with Iron.Approved, Vet Approved
EnalaprilatThe risk or severity of adverse effects can be increased when Enalaprilat is combined with Iron.Approved
EnoxacinThe serum concentration of Enoxacin can be decreased when it is combined with Iron.Approved
EpinastineEpinastine can cause a decrease in the absorption of Iron resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
EsomeprazoleEsomeprazole can cause a decrease in the absorption of Iron resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
FamotidineFamotidine can cause a decrease in the absorption of Iron resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
FleroxacinThe serum concentration of Fleroxacin can be decreased when it is combined with Iron.Approved
FlumequineThe serum concentration of Flumequine can be decreased when it is combined with Iron.Withdrawn
FosinoprilThe risk or severity of adverse effects can be increased when Fosinopril is combined with Iron.Approved
GarenoxacinThe serum concentration of Garenoxacin can be decreased when it is combined with Iron.Investigational
GatifloxacinThe serum concentration of Gatifloxacin can be decreased when it is combined with Iron.Approved, Investigational
GemifloxacinThe serum concentration of Gemifloxacin can be decreased when it is combined with Iron.Approved, Investigational
GrepafloxacinThe serum concentration of Grepafloxacin can be decreased when it is combined with Iron.Withdrawn
ImidaprilThe risk or severity of adverse effects can be increased when Imidapril is combined with Iron.Investigational
LansoprazoleLansoprazole can cause a decrease in the absorption of Iron resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
LevodopaThe serum concentration of Levodopa can be decreased when it is combined with Iron.Approved
LevofloxacinThe serum concentration of Levofloxacin can be decreased when it is combined with Iron.Approved, Investigational
LevothyroxineThe serum concentration of Levothyroxine can be decreased when it is combined with Iron.Approved
Lipoic AcidIron can cause a decrease in the absorption of Lipoic Acid resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Nutraceutical
LisinoprilThe risk or severity of adverse effects can be increased when Lisinopril is combined with Iron.Approved, Investigational
LomefloxacinThe serum concentration of Lomefloxacin can be decreased when it is combined with Iron.Approved
MagaldrateMagaldrate can cause a decrease in the absorption of Iron resulting in a reduced serum concentration and potentially a decrease in efficacy.Withdrawn
Magnesium carbonateMagnesium carbonate can cause a decrease in the absorption of Iron resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Magnesium HydroxideMagnesium hydroxide can cause a decrease in the absorption of Iron resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Magnesium oxideMagnesium oxide can cause a decrease in the absorption of Iron resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Magnesium TrisilicateMagnesium Trisilicate can cause a decrease in the absorption of Iron resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
MethanthelineMethantheline can cause a decrease in the absorption of Iron resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
MethyldopaThe serum concentration of Methyldopa can be decreased when it is combined with Iron.Approved
MetiamideMetiamide can cause a decrease in the absorption of Iron resulting in a reduced serum concentration and potentially a decrease in efficacy.Experimental
MinocyclineMinocycline can cause a decrease in the absorption of Iron resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
MoexiprilThe risk or severity of adverse effects can be increased when Moexipril is combined with Iron.Approved
MoxifloxacinThe serum concentration of Moxifloxacin can be decreased when it is combined with Iron.Approved, Investigational
Nalidixic AcidThe serum concentration of Nalidixic Acid can be decreased when it is combined with Iron.Approved
NemonoxacinThe serum concentration of Nemonoxacin can be decreased when it is combined with Iron.Investigational
NizatidineNizatidine can cause a decrease in the absorption of Iron resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
NorfloxacinThe serum concentration of Norfloxacin can be decreased when it is combined with Iron.Approved
OfloxacinThe serum concentration of Ofloxacin can be decreased when it is combined with Iron.Approved
OlanzapineOlanzapine can cause a decrease in the absorption of Iron resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
OmapatrilatThe risk or severity of adverse effects can be increased when Omapatrilat is combined with Iron.Investigational
OmeprazoleOmeprazole can cause a decrease in the absorption of Iron resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational, Vet Approved
OxytetracyclineOxytetracycline can cause a decrease in the absorption of Iron resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Vet Approved
PancrelipasePancrelipase can cause a decrease in the absorption of Iron resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
PantoprazolePantoprazole can cause a decrease in the absorption of Iron resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
PazufloxacinThe serum concentration of Pazufloxacin can be decreased when it is combined with Iron.Investigational
PefloxacinThe serum concentration of Pefloxacin can be decreased when it is combined with Iron.Approved
PenicillamineIron can cause a decrease in the absorption of Penicillamine resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
PerindoprilThe risk or severity of adverse effects can be increased when Perindopril is combined with Iron.Approved
PrulifloxacinThe serum concentration of Prulifloxacin can be decreased when it is combined with Iron.Investigational
QuinaprilThe risk or severity of adverse effects can be increased when Quinapril is combined with Iron.Approved, Investigational
RabeprazoleRabeprazole can cause a decrease in the absorption of Iron resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
RamiprilThe risk or severity of adverse effects can be increased when Ramipril is combined with Iron.Approved
RanitidineRanitidine can cause a decrease in the absorption of Iron resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
RescinnamineThe risk or severity of adverse effects can be increased when Rescinnamine is combined with Iron.Approved
RosoxacinThe serum concentration of Rosoxacin can be decreased when it is combined with Iron.Approved
Roxatidine acetateRoxatidine acetate can cause a decrease in the absorption of Iron resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Sodium glycerophosphateIron can cause a decrease in the absorption of Sodium glycerophosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Sodium phosphateIron can cause a decrease in the absorption of Sodium phosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
SparfloxacinThe serum concentration of Sparfloxacin can be decreased when it is combined with Iron.Approved
SpiraprilThe risk or severity of adverse effects can be increased when Spirapril is combined with Iron.Approved
TemafloxacinThe serum concentration of Temafloxacin can be decreased when it is combined with Iron.Withdrawn
TemocaprilThe risk or severity of adverse effects can be increased when Temocapril is combined with Iron.Experimental, Investigational
TetracyclineTetracycline can cause a decrease in the absorption of Iron resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Vet Approved
TrandolaprilThe risk or severity of adverse effects can be increased when Trandolapril is combined with Iron.Approved
TriethylenetetramineThe serum concentration of Iron can be decreased when it is combined with Triethylenetetramine.Approved
TrovafloxacinThe serum concentration of Trovafloxacin can be decreased when it is combined with Iron.Approved, Withdrawn
Food InteractionsNot Available
References
Synthesis Reference

Walter Lugscheider, Paul Mullner, Wilhelm Schiffer, Alois Leutgob, "Arrangement for producing metals, such as molten pig iron, steel pre-material and ferroalloys." U.S. Patent US4617671, issued 0000.

US4617671
General ReferencesNot Available
External Links
ATC CodesB03AE02 — Iron, multivitamins and folic acidB03AE01 — Iron, vitamin b12 and folic acidB03AD02 — Ferrous fumarateB03AA10 — Ferrous ascorbateB03AA01 — Ferrous glycine sulfateB03AE04 — Iron, multivitamins and mineralsB03AE03 — Iron and multivitaminsA11AA01 — Multivitamins and ironB03AA02 — Ferrous fumarateB03AA06 — Ferrous succinateB03AA03 — Ferrous gluconate
AHFS Codes
  • 20:04.00
  • 20:04.04
  • 88:29.00*
  • 92:02.00*
PDB EntriesNot Available
FDA labelDownload (100 KB)
MSDSDownload (75.6 KB)
Clinical Trials
Clinical Trials
PhaseStatusPurposeConditionsCount
0CompletedTreatmentIron Deficiency Anemia of Pregnancy1
1CompletedNot AvailableHealthy Volunteers1
1CompletedBasic ScienceIron-Deficiency Anemias / Kidney Failure,Chronic1
1CompletedPreventionBacterial Infection Due to Helicobacter Pylori (H. Pylori) / Healthy Participants / Non-anemic Children1
1CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections1
1CompletedTreatmentIron-refractory, Iron-deficiency Anemia (IRIDA)1
1, 2Not Yet RecruitingPreventionPrevention of Anemia1
2CompletedTreatmentAnemias2
2CompletedTreatmentAngiodysplasia / Gastric Antral Vascular Ectasia / Obscure Gastrointestinal Bleeding / Thalidomide1
2CompletedTreatmentAutism Spectrum Disorder (ASD) / Sleeplessness1
2CompletedTreatmentChronic Arsenic Poisoning1
2CompletedTreatmentChronic Kidney Disease (CKD)1
2Not Yet RecruitingTreatmentIron-Refractory Iron-Deficiency Anemia1
2RecruitingSupportive CareMetastatic Colorectal Cancers1
2RecruitingTreatmentAnemias / Congenital Heart Disease (CHD) / Cyanosis / Cyanotic Congenital Heart Disease1
2RecruitingTreatmentIron Deficiency Anemia (IDA) / Restless Legs Syndrome (RLS)1
2RecruitingTreatmentIron-Deficiency Anemias1
2Unknown StatusPreventionLead Toxicity1
2Unknown StatusTreatmentAnemias1
2WithdrawnTreatmentInflammatory Bowel Diseases (IBD) / Iron Deficiency Anemia (IDA)1
2, 3CompletedTreatmentHaematological Malignancies1
2, 3CompletedTreatmentHeart Failure, Systolic / Iron-Deficiency Anemias1
2, 3CompletedTreatmentIron Deficiency Anemia (IDA)1
2, 3TerminatedTreatmentIron-Deficiency Anemias / Postpartum Depression / Puerperal Disorders1
3Active Not RecruitingTreatmentFibromyalgia, Primary1
3CompletedNot AvailableAnemias / Haematopoiesis1
3CompletedNot AvailableChronic Kidney Disease (CKD)1
3CompletedDiagnosticAnemias1
3CompletedPreventionIron Deficiency1
3CompletedSupportive CareAnemias / Postoperative Blood Loss1
3CompletedTreatmentAnemias5
3CompletedTreatmentChronic Kidney Disease (CKD) / Iron Deficiency Anemia (IDA)1
3CompletedTreatmentHip Fractures1
3CompletedTreatmentIron Deficiency1
3CompletedTreatmentIron Deficiency Anemia (IDA)2
3CompletedTreatmentIron-Deficiency Anemias / Obese experiencing rapid weight loss1
3CompletedTreatmentPostpartum Anemia1
3CompletedTreatmentUterine Leiomyomas1
3RecruitingTreatmentAnemias5
3RecruitingTreatmentCrohn's Disease (CD) / Inflammatory Bowel Diseases (IBD) / Iron-Deficiency Anemias1
3TerminatedPreventionContraception1
3TerminatedTreatmentIron Deficiency Anemia (IDA)1
3TerminatedTreatmentIron Deficiency Anemia (IDA) / Nondialysis Dependent Chronic Kidney Disease1
3WithdrawnTreatmentLeiomyomas1
4Active Not RecruitingTreatmentIron Deficiency Anemia (IDA) Secondary to Inflammatory Bowel Disease (IBD) or Gastric Bypass1
4CompletedTreatmentAnemias1
4CompletedTreatmentAnemias / Hemorrhage, Gastrointestinal1
4CompletedTreatmentAnemias / Neoplasms, Colorectal1
4CompletedTreatmentCrohn's Disease (CD) / Ulcerative Colitis (UC)1
4CompletedTreatmentHyperemesis Gravidarum / Morning Sickness / Nausea / Pregnancy / Vomiting1
4CompletedTreatmentIron Deficiency / Tiredness1
4CompletedTreatmentIron-Deficiency Anemias / Kidney Failure,Chronic2
4CompletedTreatmentLiposomated Iron / Parenteral Iron Therapy / Y-de-Roux Gastric By-Pass1
4CompletedTreatmentOsteoarthritis of the Knees / Postoperative Anaemia1
4CompletedTreatmentPregnancy1
4Enrolling by InvitationDiagnosticIron Absorption / Post-gastrointestinal bypass surgery / Roux- en -y Gastric Bypass1
4Enrolling by InvitationTreatmentIron Deficiency1
4RecruitingSupportive CareIron Deficiency1
4RecruitingTreatmentAnemia During Pregnancy1
4RecruitingTreatmentAnemias / Carcinoma, Colorectal / General Surgery1
4RecruitingTreatmentAnemias / Hematopoietic Stem Cell Transplantation (HSCT) / Malignant Lymphomas1
4RecruitingTreatmentHeart Failure With Reduced Ejection Fraction (HFrEF) / Iron Deficiency1
4RecruitingTreatmentIron-Deficiency Anemias1
4RecruitingTreatmentLeiomyomas1
4TerminatedTreatmentChronic Kidney Disease (CKD) / Iron-Deficiency Anemias1
4TerminatedTreatmentLymphoid Disease / Solid Cancer Metastatic Disease1
4Unknown StatusPreventionAnemias / Child Behavior Disorders / Cognitive Manifestations / Iron-Deficiency1
4Unknown StatusTreatmentAnemias1
4Unknown StatusTreatmentAnemias / Iron Deficiency1
4Unknown StatusTreatmentIron Deficiency Anemia (IDA)1
4Unknown StatusTreatmentIron Deficiency Anemia (IDA) / Neoplasms, Colorectal1
4Unknown StatusTreatmentPostoperative Anaemia1
4WithdrawnTreatmentIron Deficiency1
Not AvailableCompletedNot AvailableAnemias1
Not AvailableCompletedNot AvailableAnemias / Iron Deficiency / Plasmodium Infections / Schistosomiasis Infection1
Not AvailableCompletedBasic ScienceCardiovascular Disease (CVD)1
Not AvailableCompletedBasic ScienceCritical Illness1
Not AvailableCompletedBasic ScienceIron Bioavailability1
Not AvailableCompletedPreventionAnaemia in Children1
Not AvailableCompletedPreventionIron Metabolic Homeostasis1
Not AvailableCompletedPreventionPostpartum Anemia1
Not AvailableCompletedPreventionVisceral Leishmaniasis1
Not AvailableCompletedTreatmentAnemias1
Not AvailableCompletedTreatmentAnemias / Helminthiases / Schistosoma infection1
Not AvailableCompletedTreatmentBacterial Infection Due to Helicobacter Pylori (H. Pylori) / Children / Iron Deficiency Anemia (IDA) / No Systemic Infection / Not Severely Malnourished1
Not AvailableCompletedTreatmentCrohn's Disease (CD)1
Not AvailableCompletedTreatmentCystic Fibrosis (CF) / Iron-Deficiency Anemias1
Not AvailableCompletedTreatmentVulvovaginal Candidiasis1
Not AvailableNot Yet RecruitingDiagnosticIron Absorption1
Not AvailableNot Yet RecruitingPreventionAnemias / Hip Fractures1
Not AvailableNot Yet RecruitingTreatmentComplex Valvular Heart Surgery1
Not AvailableNot Yet RecruitingTreatmentCraniosynostosis1
Not AvailableRecruitingDiagnosticHFE-Associated Hereditary Hemochromatosis / Myocardial Iron Overload1
Not AvailableRecruitingTreatmentAnemia in Pregnancy1
Not AvailableRecruitingTreatmentAnemias / Chronic Kidney Disease (CKD) / Iron Deficiency1
Not AvailableRecruitingTreatmentEPP / Protoporphyria, Erythropoietic / X-Linked Protoporphyria / XLP1
Not AvailableRecruitingTreatmentHereditary Haemorrhagic Telangiectasia (HHT)1
Not AvailableTerminatedPreventionAnemias / Plasmodium Infections1
Not AvailableUnknown StatusTreatmentAnemias / Hemorrhage1
Not AvailableUnknown StatusTreatmentHealthy Volunteers1
Not AvailableUnknown StatusTreatmentRenal Failure Chronic Requiring Hemodialysis1
Not AvailableWithdrawnPreventionAnemias1
Not AvailableWithdrawnPreventionEndometriotic Cysts1
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
Capsule; liquidOral
CapsuleOral33 mg
TabletOral25 mg
TabletOral18 mg
Kit
TabletOral
LiquidIntramuscular; Intravenous50 mg
Tablet, chewableOral
LotionTopical
TabletOral28 mg
LiquidOral16.7 mg
Solution / dropsOral125 mg
TabletOral65 mg
Tablet, extended releaseOral
Tablet, extended releaseOral105 mg
Tablet, film coatedOral
TabletOral200 mg
ElixirOral220 mg/5mL
TabletOral325 mg/1
TabletOral65 mg/1
Tablet, film coatedOral325 mg/1
TabletOral325 mg
SyrupOral35 mg
SyrupOral
Capsule, extended releaseOral30 mg
CapsuleOral150 mg/1
CapsuleOral40 mg
TabletOral30 mg
Tablet, extended releaseOral35 mg
TabletOral37 mg
CapsuleOral50 mg
Tablet, extended releaseOral50 mg
Tablet, chewableOral15 mg/1
TabletOral35 mg
Tablet, effervescentOral
TabletOral6 mg
Liquid; tabletOral
Solution / dropsOral
LiquidOral
SolutionOral
Capsule, gelatin coatedOral
CapsuleOral
Tablet, delayed releaseOral300 mg
TabletOral300 mg
PowderOral
CapsuleOral100 mg
Tablet, delayed releaseOral60 mg
LiquidIntravenous20 mg
Tablet, coatedOral
Capsule, liquid filledOral
Prices
Unit descriptionCostUnit
Iron chews 15 mg tablet chew0.29USD tablet
Ferrous sulfate 28 mg tablet0.04USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point (°C)1538 °CNot Available
Predicted Properties
PropertyValueSource
logP-0.77ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity0 m3·mol-1ChemAxon
Polarizability1.78 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9838
Blood Brain Barrier+0.9733
Caco-2 permeable+0.7354
P-glycoprotein substrateNon-substrate0.885
P-glycoprotein inhibitor INon-inhibitor0.9787
P-glycoprotein inhibitor IINon-inhibitor0.9858
Renal organic cation transporterNon-inhibitor0.9108
CYP450 2C9 substrateNon-substrate0.8466
CYP450 2D6 substrateNon-substrate0.8259
CYP450 3A4 substrateNon-substrate0.8158
CYP450 1A2 substrateNon-inhibitor0.8807
CYP450 2C9 inhibitorNon-inhibitor0.9373
CYP450 2D6 inhibitorNon-inhibitor0.9708
CYP450 2C19 inhibitorNon-inhibitor0.9553
CYP450 3A4 inhibitorNon-inhibitor0.988
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.882
Ames testNon AMES toxic0.9633
CarcinogenicityCarcinogens 0.664
BiodegradationReady biodegradable0.7326
Rat acute toxicity2.0135 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9547
hERG inhibition (predictor II)Non-inhibitor0.9746
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
Taxonomy
DescriptionThis compound belongs to the class of chemical entities known as homogeneous transition metal compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a transition metal atom.
KingdomChemical entities
Super ClassInorganic compounds
ClassHomogeneous metal compounds
Sub ClassHomogeneous transition metal compounds
Direct ParentHomogeneous transition metal compounds
Alternative ParentsNot Available
SubstituentsHomogeneous transition metal
Molecular FrameworkNot Available
External Descriptorselemental iron (CHEBI:82664 )

Targets

Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Virus receptor activity
Specific Function:
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for devel...
Gene Name:
TFRC
Uniprot ID:
P02786
Uniprot Name:
Transferrin receptor protein 1
Molecular Weight:
84870.665 Da
References
  1. Hemadi M, Ha-Duong NT, El Hage Chahine JM: The mechanism of iron release from the transferrin-receptor 1 adduct. J Mol Biol. 2006 May 12;358(4):1125-36. Epub 2006 Mar 13. [PubMed:16564538 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Peptidyl-proline dioxygenase activity
Specific Function:
Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HI...
Gene Name:
EGLN1
Uniprot ID:
Q9GZT9
Uniprot Name:
Egl nine homolog 1
Molecular Weight:
46020.585 Da
References
  1. Davidson TL, Chen H, Di Toro DM, D'Angelo G, Costa M: Soluble nickel inhibits HIF-prolyl-hydroxylases creating persistent hypoxic signaling in A549 cells. Mol Carcinog. 2006 Jul;45(7):479-89. [PubMed:16649251 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
cofactor
General Function:
Transcription factor binding
Specific Function:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylatio...
Gene Name:
HDAC8
Uniprot ID:
Q9BY41
Uniprot Name:
Histone deacetylase 8
Molecular Weight:
41757.29 Da
References
  1. Gantt SL, Gattis SG, Fierke CA: Catalytic activity and inhibition of human histone deacetylase 8 is dependent on the identity of the active site metal ion. Biochemistry. 2006 May 16;45(19):6170-8. [PubMed:16681389 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation. It is predicted to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia.
Specific Function:
Hemoglobin binding
Gene Name:
AHSP
Uniprot ID:
Q9NZD4
Uniprot Name:
Alpha-hemoglobin-stabilizing protein
Molecular Weight:
11840.325 Da
References
  1. Zhou S, Olson JS, Fabian M, Weiss MJ, Gow AJ: Biochemical fates of alpha hemoglobin bound to alpha hemoglobin-stabilizing protein AHSP. J Biol Chem. 2006 Oct 27;281(43):32611-8. Epub 2006 Aug 10. [PubMed:16901899 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Oxygen transporter activity
Specific Function:
Involved in oxygen transport from the lung to the various peripheral tissues.
Gene Name:
HBA1
Uniprot ID:
P69905
Uniprot Name:
Hemoglobin subunit alpha
Molecular Weight:
15257.405 Da
References
  1. Zhou S, Olson JS, Fabian M, Weiss MJ, Gow AJ: Biochemical fates of alpha hemoglobin bound to alpha hemoglobin-stabilizing protein AHSP. J Biol Chem. 2006 Oct 27;281(43):32611-8. Epub 2006 Aug 10. [PubMed:16901899 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has only been shown using heterologous overexpression systems. Modulates the RNA-binding activity of ACO1.
Specific Function:
2 iron, 2 sulfur cluster binding
Gene Name:
FXN
Uniprot ID:
Q16595
Uniprot Name:
Frataxin, mitochondrial
Molecular Weight:
23134.895 Da
References
  1. Bencze KZ, Kondapalli KC, Cook JD, McMahon S, Millan-Pacheco C, Pastor N, Stemmler TL: The structure and function of frataxin. Crit Rev Biochem Mol Biol. 2006 Sep-Oct;41(5):269-91. [PubMed:16911956 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Iron ion binding
Specific Function:
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).
Gene Name:
FTH1
Uniprot ID:
P02794
Uniprot Name:
Ferritin heavy chain
Molecular Weight:
21225.47 Da
References
  1. Toussaint L, Bertrand L, Hue L, Crichton RR, Declercq JP: High-resolution X-ray structures of human apoferritin H-chain mutants correlated with their activity and metal-binding sites. J Mol Biol. 2007 Jan 12;365(2):440-52. Epub 2006 Oct 7. [PubMed:17070541 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Specific Function:
5'-3' exonuclease activity
Gene Name:
FEN1
Uniprot ID:
P39748
Uniprot Name:
Flap endonuclease 1
Molecular Weight:
42592.635 Da
References
  1. Hegde ML, Hegde PM, Holthauzen LM, Hazra TK, Rao KS, Mitra S: Specific Inhibition of NEIL-initiated repair of oxidized base damage in human genome by copper and iron: potential etiological linkage to neurodegenerative diseases. J Biol Chem. 2010 Sep 10;285(37):28812-25. doi: 10.1074/jbc.M110.126664. Epub 2010 Jul 9. [PubMed:20622253 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Not Available
Specific Function:
Not Available
Gene Name:
NEIL1
Uniprot ID:
Q96FI4
Uniprot Name:
Endonuclease 8-like 1
Molecular Weight:
43683.625 Da
References
  1. Hegde ML, Hegde PM, Holthauzen LM, Hazra TK, Rao KS, Mitra S: Specific Inhibition of NEIL-initiated repair of oxidized base damage in human genome by copper and iron: potential etiological linkage to neurodegenerative diseases. J Biol Chem. 2010 Sep 10;285(37):28812-25. doi: 10.1074/jbc.M110.126664. Epub 2010 Jul 9. [PubMed:20622253 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Zinc ion binding
Specific Function:
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase...
Gene Name:
NEIL2
Uniprot ID:
Q969S2
Uniprot Name:
Endonuclease 8-like 2
Molecular Weight:
36826.285 Da
References
  1. Hegde ML, Hegde PM, Holthauzen LM, Hazra TK, Rao KS, Mitra S: Specific Inhibition of NEIL-initiated repair of oxidized base damage in human genome by copper and iron: potential etiological linkage to neurodegenerative diseases. J Biol Chem. 2010 Sep 10;285(37):28812-25. doi: 10.1074/jbc.M110.126664. Epub 2010 Jul 9. [PubMed:20622253 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Microtubule binding
Specific Function:
Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA po...
Gene Name:
POLB
Uniprot ID:
P06746
Uniprot Name:
DNA polymerase beta
Molecular Weight:
38177.34 Da
References
  1. Hegde ML, Hegde PM, Holthauzen LM, Hazra TK, Rao KS, Mitra S: Specific Inhibition of NEIL-initiated repair of oxidized base damage in human genome by copper and iron: potential etiological linkage to neurodegenerative diseases. J Biol Chem. 2010 Sep 10;285(37):28812-25. doi: 10.1074/jbc.M110.126664. Epub 2010 Jul 9. [PubMed:20622253 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Ferroxidase activity
Specific Function:
Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pul...
Gene Name:
CP
Uniprot ID:
P00450
Uniprot Name:
Ceruloplasmin
Molecular Weight:
122204.45 Da
References
  1. Ha-Duong NT, Eid C, Hemadi M, El Hage Chahine JM: In vitro interaction between ceruloplasmin and human serum transferrin. Biochemistry. 2010 Dec 7;49(48):10261-3. doi: 10.1021/bi1014503. Epub 2010 Nov 9. [PubMed:21049900 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Transferrin receptor binding
Specific Function:
Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.
Gene Name:
TF
Uniprot ID:
P02787
Uniprot Name:
Serotransferrin
Molecular Weight:
77063.195 Da
References
  1. Ha-Duong NT, Eid C, Hemadi M, El Hage Chahine JM: In vitro interaction between ceruloplasmin and human serum transferrin. Biochemistry. 2010 Dec 7;49(48):10261-3. doi: 10.1021/bi1014503. Epub 2010 Nov 9. [PubMed:21049900 ]
Drug created on August 29, 2007 10:01 / Updated on September 18, 2017 13:13