Vitamin D and Analogues

Name
Vitamin D and Analogues
Accession Number
DBCAT002152  (DBCAT000304, DBCAT000305, DBCAT000306, DBCAT000310, DBCAT001254, DBCAT003285, DBCAT003286, DBCAT003471)
Description

A vitamin that includes both CHOLECALCIFEROLS and ERGOCALCIFEROLS, which have the common effect of preventing or curing RICKETS in animals. It can also be viewed as a hormone since it can be formed in SKIN by action of ULTRAVIOLET RAYS upon the precursors, 7-dehydrocholesterol and ERGOSTEROL, and acts on VITAMIN D RECEPTORS to regulate CALCIUM in opposition to PARATHYROID HORMONE.

ATC Classification
Drugs
DrugDrug Description
DoxercalciferolA synthetic vitamin D2 analog used to treat secondary hyperparathyroidism in patients with chronic kidney disease with or without therapy of dialysis.
ParicalcitolA vitamin D analog used to treat hyperparathyroidism associated with stage 3 or greater chronic kidney disease.
SeocalcitolNot Available
InecalcitolInvestigated for use/treatment in prostate cancer, psoriasis and hyperparathyroidism.
BecocalcidiolFor topical treatment of psoriasis and psoriatic disorders.
EldecalcitolInvestigated for use/treatment in osteoporosis.
ElocalcitolInvestigated for use/treatment in benign prostatic hyperplasia, urinary incontinence, prostate disorders, and infertility.
MaxacalcitolNot Annotated
1alpha-Hydroxyvitamin D51alpha-Hydroxyvitamin D5 (CARD-024) has been used in trials studying the treatment of Drug Safety and Heart; Disease, Activity.
TacalcitolNot Annotated
CalcifediolAn active metabolite of vitamin D used to treat hyperparathyroidism as well as to combat hypocalcemia in dialysis patients.
ErgocalciferolA vitamin found in many supplement products.
DihydrotachysterolA synthetic analog of vitamin D that does not require renal activation like vitamin D2 or Vitamin D3.
CalcipotriolA topical synthetic vitamin D2 derivative used in the treatment of plaque psoriasis.
Vitamin DAn ingredient found in a variety of supplements and vitamins.
CalcitriolAn active metabolite of vitamin D that is used to treat hyperparathyroidism and is also used in dialysis patients to combat hypocalcemia.
CholecalciferolA form of Vitamin D used in the treatment of specific medical conditions such as refractory rickets, hypoparathyroidism, and familial hypophosphatemia, as well as osteoporosis and chronic kidney disease.
AlfacalcidolA vitamin D analogue used for the management of hypocalcemia, secondary hyperparathyroidism, and osteodystrophy in patients with chronic renal failure.
1alpha,24S-Dihydroxyvitamin D2Investigated for use/treatment in parathyroid disorders.
24-Homo-1,25-dihydroxyvitamin D324-Homo-1,25-dihydroxyvitamin D3 is a novel vitamin D analogue.
Previtamin D(3)Not Annotated
LexacalcitolLexacalcitol is a solid. This compound belongs to the vitamin D and derivatives class of chemicals. These are compounds containing a secosteroid backbone, usually secoergostane or secocholestane. It is known...
Drugs & Drug Targets
DrugTargetType
DoxercalciferolSterol 26-hydroxylase, mitochondrialenzyme
DoxercalciferolVitamin D3 receptortarget
ParicalcitolVitamin D3 receptortarget
Paricalcitol1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialenzyme
ParicalcitolCytochrome P450 3A4enzyme
ParicalcitolUDP-glucuronosyltransferase 1-4enzyme
SeocalcitolVitamin D3 receptortarget
InecalcitolVitamin D3 receptortarget
BecocalcidiolMediator of RNA polymerase II transcription subunit 1target
BecocalcidiolVitamin D3 receptortarget
EldecalcitolVitamin D3 receptortarget
ElocalcitolVitamin D3 receptortarget
Calcifediol25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrialenzyme
CalcifediolVitamin D3 receptortarget
Calcifediol1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialenzyme
ErgocalciferolVitamin D3 receptortarget
Ergocalciferol1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialenzyme
Ergocalciferol25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrialenzyme
ErgocalciferolSterol 26-hydroxylase, mitochondrialenzyme
ErgocalciferolVitamin D 25-hydroxylaseenzyme
ErgocalciferolVitamin D-binding proteincarrier
ErgocalciferolVoltage-dependent calcium channeltarget
ErgocalciferolRibulose-phosphate 3-epimeraseenzyme
ErgocalciferolCholesterol side-chain cleavage enzyme, mitochondrialenzyme
DihydrotachysterolVitamin D3 receptortarget
CalcipotriolVitamin D3 receptortarget
CalcipotriolMyeloperoxidaseenzyme
Calcipotriol1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialenzyme
Vitamin DVitamin D3 receptortarget
Vitamin DVitamin D-binding proteintarget
Vitamin DVitamin D 25-hydroxylaseenzyme
Vitamin D25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrialenzyme
Vitamin DCytochrome P450 3A4enzyme
CalcitriolVitamin D3 receptortarget
Calcitriol1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialenzyme
CalcitriolCytochrome P450 3A4enzyme
CalcitriolHomeobox protein Hox-A10target
CalcitriolVitamin D-binding proteincarrier
CholecalciferolVitamin D-binding proteincarrier
CholecalciferolCholesterol side-chain cleavage enzyme, mitochondrialenzyme
CholecalciferolVitamin D 25-hydroxylaseenzyme
CholecalciferolSterol 26-hydroxylase, mitochondrialenzyme
CholecalciferolCytochrome P450 2J2enzyme
CholecalciferolCytochrome P450 3A4enzyme
CholecalciferolVitamin D3 receptortarget
CholecalciferolCytochrome P450 1A1enzyme
CholecalciferolCytochrome P450 2C8enzyme
AlfacalcidolVitamin D-binding proteincarrier
AlfacalcidolVitamin D3 receptortarget
Alfacalcidol25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrialtarget
AlfacalcidolRetinoic acid receptor RXR-alphatarget
LexacalcitolVitamin D3 receptortarget