Identification

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Name
Vitamin D
Accession Number
DB11094
Type
Small Molecule
Groups
Approved, Nutraceutical, Vet approved
Description

Vitamin D ultimately comprises a group of lipid-soluble secosteroids responsible for a variety of biological effects, some of which include increasing the intestinal absorption of calcium, magnesium, and phosphate. With reference to human use, there are 2 main forms of vitamin D - vitamin D3 (cholecalciferol) and vitamin D2 (ergocalciferol). When non-specific references are made about 'vitamin d', the references are usually about the use of vitamin D3 and/or D2.

Vitamin D3 and D2 require hydroxylation in order to become biologically active in the human body. Since vitamin D can be endogenously synthesized in adequate amounts by most mammals exposed to sufficient quantities of sunlight, vitamin D functions like a hormone on vitamin D receptors to regulate calcium in opposition to parathyroid hormone. Vitamin D plays an essential physiological role in maintaining calcium homeostasis and metabolism. There are several different vitamin D supplements that are given to treat or to prevent osteomalacia and rickets, or to meet the daily criteria of vitamin D consumption.

Synonyms
  • Calciferol
  • Vitamin D NOS
  • Vitamin D, unspecified form
Active Moieties
NameKindUNIICASInChI Key
Cholecalciferolunknown1C6V77QF4167-97-0QYSXJUFSXHHAJI-YRZJJWOYSA-N
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
OstoforteCapsuleOralMerck Ltd.1951-12-312007-10-31Canada
Radiostol Solution 100000iu/mlLiquidOralAllen & Hanburys A Glaxo Canada Ltd. Co.1951-12-311996-09-10Canada
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
D Caps 400 UnitsCapsuleOralTwin Laboratories Inc.1995-12-311999-11-10Canada
Theraplex D Tab 250unitTabletOralTherapeutic Foods Co.1987-12-311996-09-09Canada
Vitamin DTablet400 unitOralHealth Wise Nutrition Inc.2000-04-032002-07-18Canada
Vitamin D 1000 Iu TabletsTabletOralNatural Factors Nutritional Products Ltd.1988-12-312008-07-17Canada
Vitamin D 200unitCapsuleOralSwiss Herbal Remedies Ltd.1972-12-311999-08-13Canada
Vitamin D Tab 1000unitTabletOralSwiss Herbal Remedies Ltd.1974-12-312009-08-04Canada
Vitamin D Tab 400unit ChewableTabletOralLab Gernetic Int Ltee1985-12-311997-02-21Canada
Vitamine DCapsuleOralPharmalab Inc.1995-12-311997-08-08Canada
Vitamine D 1000 U.I.TabletOralGamme Nature1986-12-312008-07-31Canada
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
50 PlusVitamin D (400 unit) + Ascorbic acid (200 mg) + Biotin (20 mcg) + Choline bitartrate (20 mg) + Cyanocobalamin (20 mcg) + Folic acid (.2 mg) + Inositol (20 mg) + Niacin (20 mg) + Calcium pantothenate (20 mg) + Pyridoxine hydrochloride (20 mg) + Racemethionine (20 mg) + Riboflavin (20 mg) + Thiamine hydrochloride (20 mg) + Vitamin A palmitate (10000 unit) + Vitamin E (20 unit)TabletOralQuest Vitamins A Div Of Purity Life Health Products1998-08-042001-07-06Canada
A and D OintmentVitamin D (213 unit) + Vitamin A (1500 unit)OintmentTopicalSchering Plough1951-12-312002-07-12Canada
A D Calcium TabVitamin D (400 unit) + Calcium (126 mg) + Vitamin A (5000 unit)TabletOralStar Pharmaceuticals, Llc1979-12-311999-07-21Canada
A-D Calcium CapVitamin D (133 unit) + Calcium (170 mg) + Vitamin A (2500 unit)CapsuleOralVitalab1990-12-312005-07-12Canada
Ad & Calcium CapVitamin D (133 unit) + Calcium (170 mg) + Vitamin A (2500 unit)CapsuleOralLaboratoire Lalco Inc.1977-12-312001-10-15Canada
Ad Calcium CapVitamin D (133 unit) + Calcium (170 mg) + Vitamin A (2500 unit)CapsuleOralLes Produits Gerbex Inc.1979-12-311997-08-11Canada
Adc ComprimesVitamin D (200 unit) + Ascorbic acid (250 mg) + Vitamin A acetate (5000 unit)TabletOralBio Vita1990-12-311996-09-09Canada
Advanced B & T FormulaVitamin D (66.67 unit) + Ascorbic acid (33.3 mg) + Calcium (200 mg) + Chromium (33.33 mcg) + Copper (0.5 mg) + Cyanocobalamin (6.67 mcg) + Folic acid (0.133 mg) + Iron (1.67 mg) + Magnesium (83.3 mg) + Manganese (3.33 mg) + Nicotinamide (6.67 mg) + Calcium pantothenate (5 mg) + Phosphorus (100 mg) + Potassium (16.67 mg) + Pyridoxine hydrochloride (6.67 mg) + Riboflavin (2.67 mg) + Selenium (33.33 mcg) + Silicon (0.333 mg) + Sodium molybdate (16.67 mcg) + Thiamine (2.67 mg) + Vanadium (8.33 mg) + Zinc (5 mg)CapsuleOralNutraceutical CorporationNot applicableNot applicableCanada
Anaplex TabVitamin D (133.33 unit) + Ascorbic acid (40 mg) + Calcium (160 mg) + Iodine (.05 mg) + Magnesium oxide (50 mg) + Nicotinamide (30 mg) + Calcium pantothenate (15 mg) + Phosphorus (75.33 mg) + Potassium chloride (20 mg) + Pyridoxine hydrochloride (40 mg) + Vitamin A palmitate (2000 unit)TabletOralAnabolic Laboratories Inc.1975-12-311996-10-02Canada
AppedrineVitamin D (133 unit) + Benzocaine (3 mg) + Ferrous fumarate (3.33 mg) + Nicotinamide (3.33 mg) + Riboflavin (.4 mg) + Sodium ascorbate (10 mg) + Thiamine hydrochloride (.33 mg) + Vitamin A (1333 unit)TabletOralChattem, Inc.1975-12-312004-07-08Canada
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
CitraNatal 90 DHAVitamin D (400 [iU]/1) + Ascorbic acid (120 mg/1) + Calcium citrate tetrahydrate (160 mg/1) + Cupric oxide (2 mg/1) + Docusate sodium (50 mg/1) + Folic acid (1 mg/1) + Iron (90 mg/1) + Nicotinamide (20 mg/1) + Potassium triiodide (150 ug/1) + Pyridoxine hydrochloride (20 mg/1) + Riboprine (3.4 mg/1) + Thiamine chloride (3 mg/1) + Zinc oxide (25 mg/1) + alpha-Tocopherol acetate (30 [iU]/1)TabletOralMission Pharmacal2010-02-01Not applicableUs
CitraNatal 90 DHAVitamin D (400 [iU]/1) + Ascorbic acid (120 mg/1) + Calcium citrate tetrahydrate (159 mg/1) + Cupric oxide (2 mg/1) + Docusate sodium (50 mg/1) + Ferrous gluconate dihydrate (5 mg/1) + Folic acid (1 mg/1) + Iron (85 mg/1) + Nicotinamide (20 mg/1) + Potassium Iodide (150 ug/1) + Pyridoxine hydrochloride (20 mg/1) + Riboflavin (3.4 mg/1) + Thiamine chloride (3 mg/1) + Thiamine mononitrate (4.54 mg/1) + Zinc oxide (25 mg/1) + alpha-Tocopherol acetate (30 [iU]/1)TabletOralMission Pharmacal Company2014-04-11Not applicableUs
CitraNatal DHAVitamin D (400 [iU]/1) + Ascorbic acid (120 mg/1) + Calcium citrate tetrahydrate (125 mg/1) + Cupric oxide (2 mg/1) + Docusate sodium (50 mg/1) + Folic acid (1 mg/1) + Iron (27 mg/1) + Nicotinamide (20 mg/1) + Potassium Iodide (150 mg/1) + Pyridoxine hydrochloride (20 mg/1) + Riboflavin (3.4 mg/1) + Thiamine chloride (3 mg/1) + Zinc oxide (25 mg/1) + alpha-Tocopherol acetate (30 [iU]/1)TabletOralMission Pharmacal2007-11-20Not applicableUs
CitraNatal DHAVitamin D (400 [iU]/1) + Ascorbic acid (120 mg/1) + Calcium citrate tetrahydrate (124 mg/1) + Cupric oxide (2 mg/1) + Doconexent (250 mg/1) + Docusate sodium (50 mg/1) + Folic acid (1 mg/1) + Icosapent (0.625 mg/1) + Iron (27 mg/1) + Nicotinamide (20 mg/1) + Potassium Iodide (150 mg/1) + Pyridoxine hydrochloride (20 mg/1) + Riboflavin (3.4 mg/1) + Thiamine chloride (3 mg/1) + Zinc oxide (25 mg/1) + alpha-Tocopherol acetate (30 [iU]/1)KitOralMission Pharmacal Company2014-05-22Not applicableUs
CitraNatal RxVitamin D (400 [iU]/1) + Ascorbic acid (120 mg/1) + Calcium citrate tetrahydrate (125 mg/1) + Cupric oxide (2 mg/1) + Docusate sodium (50 mg/1) + Folic acid (1 mg/1) + Iron (27 mg/1) + Nicotinamide (20 mg/1) + Potassium Iodide (150 mg/1) + Pyridoxine hydrochloride (20 mg/1) + Riboflavin (3.4 mg/1) + Thiamine chloride (3 mg/1) + Zinc oxide (25 mg/1) + alpha-Tocopherol acetate (30 [iU]/1)TabletOralMission Pharmacal2007-11-26Not applicableUs
CitraNatal RxVitamin D (400 [iU]/1) + Ascorbic acid (120 mg/1) + Calcium citrate tetrahydrate (124 mg/1) + Cupric oxide (2 mg/1) + Folic acid (1 mg/1) + Iron (27 mg/1) + Nicotinamide (20 mg/1) + Potassium Iodide (150 mg/1) + Pyridoxine hydrochloride (20 mg/1) + Riboflavin (3.4 mg/1) + Thiamine chloride (3 mg/1) + Zinc oxide (25 mg/1) + alpha-Tocopherol acetate (30 [iU]/1)TabletOralMission Pharmacal2014-08-11Not applicableUs
DermacinRx FoliPlus DVitamin D (83.325 ug/1) + Folic acid (1 mg/1)Capsule, liquid filledOralPureTek Corporation2016-07-15Not applicableUs
DermacinRx PureFolixVitamin D (125 ug/1) + Folic acid (1 mg/1)TabletOralPureTek Corporation2015-11-03Not applicableUs
FolixapureVitamin D (125 ug/1) + Folic acid (1 mg/1)TabletOralShoreline Pharmaceuticals, Inc.2016-05-13Not applicableUs
M-Natal PlusVitamin D (400 [iU]/1) + Ascorbic acid (120 mg/1) + Calcium (200 mg/1) + Copper (2 mg/1) + Cyanocobalamin (12 ug/1) + Ferrous fumarate (27 mg/1) + Folic acid (1 mg/1) + Niacin (20 mg/1) + Pyridoxine hydrochloride (10 mg/1) + Riboflavin (3 mg/1) + Thiamine chloride (1.84 mg/1) + Vitamin A (4000 [iU]/1) + Zinc (25 mg/1) + alpha-Tocopherol acetate (22 [iU]/1)TabletOralMethod Pharmaceuticals, LLC2018-10-01Not applicableUs
Categories
UNII
9VU1KI44GP
CAS number
1406-16-2

Pharmacology

Indication

Vitamin D is indicated for use in the treatment of hypoparathyroidism, refractory rickets (also known as vitamin D resistant rickets), and familial hypophosphatemia Label.

Pharmacodynamics

The in vivo synthesis of the predominant two biologically active metabolites of vitamin D occurs in two steps. The first hydroxylation of vitamin D3 or D2 occurs in the liver to yield 25-hydroxyvitamin D while the second hydroxylation happens in the kidneys to give 1, 25-dihydroxyvitamin D Label. These vitamin D metabolites subsequently facilitate the active absorption of calcium and phosphorus in the small intestine, serving to increase serum calcium and phosphate levels sufficiently to allow bone mineralization Label. Conversely, these vitamin D metabolites also assist in mobilizing calcium and phosphate from bone and likely increase the reabsorption of calcium and perhaps also of phosphate via the renal tubules Label. There exists a period of 10 to 24 hours between the administration of vitamin D and the initiation of its action in the body due to the necessity of synthesis of the active vitamin D metabolites in the liver and kidneys Label. It is parathyroid hormone that is responsible for the regulation of such metabolism at the level of the kidneys Label.

Mechanism of action

Most individuals naturally generate adequate amounts of vitamin D through ordinary dietary intake of vitamin D (in some foods like eggs, fish, and cheese) and natural photochemical conversion of the vitamin D3 precursor 7-dehydrocholesterol in the skin via exposure to sunlight 6.

Conversely, vitamin D deficiency can often occur from a combination of insufficient exposure to sunlight, inadequate dietary intake of vitamin D, genetic defects with endogenous vitamin D receptor, or even severe liver or kidney disease 1. Such deficiency is known for resulting in conditions like rickets or osteomalacia, all of which reflect inadequate mineralization of bone, enhanced compensatory skeletal demineralization, resultant decreased calcium ion blood concentrations, and increases in the production and secretion of parathyroid hormone 2. Increases in parathyroid hormone stimulates the mobilization of skeletal calcium and the renal excretion of phosphorus 2. This enhanced mobilization of skeletal calcium leads towards porotic bone conditions 2.

Ordinarily, while vitamin D3 is made naturally via photochemical processes in the skin, both itself and vitamin D2 can be found in various food and pharmaceutical sources as dietary supplements. The principal biological function of vitamin D is the maintenance of normal levels of serum calcium and phosphorus in the bloodstream by enhancing the efficacy of the small intestine to absorb these minerals from the diet 2. At the liver, vitamin D3 or D2 is hydroxylated to 25-hydroxyvitamin D and then finally to the primary active metabolite 1,25-dihydroxyvitamin D in the kidney via further hydroxylation 2,1. This final metabolite binds to endogenous vitamin d receptors, which results in a variety of regulatory roles - including maintaining calcium balance, the regulation of parathyroid hormone, the promotion of the renal reabsorption of calcium, increased intestinal absorption of calcium and phosphorus, and increased calcium and phosphorus mobilization of calcium and phosphorus from bone to plasma to maintain balanced levels of each in bone and the plasma 2,1.

TargetActionsOrganism
UVitamin D3 receptorNot AvailableHumans
UVitamin D-binding proteinNot AvailableHumans
Additional Data Available
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Contraindications

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Absorption

Vitamin D3 and D2 are readily absorbed from the small intestine (proximal or distal) 2,1.

Volume of distribution
Not Available
Protein binding

Some studies suggest vitamin D3 demonstrates protein binding of 50-80% 1 while others discuss vitamin D2 having >99.8% protein binding 2.

Metabolism

In the liver, vitamin D3 and D2 are hydroxylated to calcidiol (25-hydroxycholecalciferol) 1 and ercalcidiol (25-hydroxyergocalciferol) 2, respectively, by the enzyme 25-hydroxylase. At the level of the kidney, calcidiol and ercalcidiol are hydroxylated to yield calcitriol (1,25-dihydroxycholecalciferol) 1 and ercalcitriol (1,25-dihydroxyergocalciferol) 2, the primary biologically active forms of vitamin D3 and D2 respectively, by the enzyme 1-alpha-hydroxylase.

Route of elimination

The primary excretion route of vitamin D is via the bile into the feces 3.

Half life

Although certain studies suggest the half-life of 1,25-hydroxyvitamin D3 may be approximately 15 hours, the half-life of 25-hydroxyvitamin D3 appears to have a half-life of about 15 days 7. Intriguingly however, the half-lives of any particular administration of vitamin d can vary and in general the half-lives of vitamin D2 metabolites have been demonstrated to be shorter overall than vitamin D3 half-lives with this being affected by vitamin d binding protein concentrations and genotype in particular individuals 4.

Clearance

Some studies propose an estimated clearance rate for 1,25-dihydroxyvitamin D as 31 +/- 4 ml/min in healthy adults 5.

Toxicity

The use of pharmacological or nutraceutical vitamin d and/or even excessive dietary intake of vitamin d is contraindicated in patients with hypercalcemia, malabsorption syndrome, abnormal sensitivity to the toxic effects of vitamin d, and hypervitaminosis D Label.

Hypersensitivity to vitamin d is one plausible etiologic factor in infants with idiopathic hypercalcemia - a case in which vitamin d use must be strictly restricted Label.

As vitamin d intake is available via fortified foods, dietary supplements, and clinical drug sources, serum concentrations and therapeutic dosages should be reviewed regularly and readjusted as soon as there is clinical improvement Label. Dosage levels are required to be individualized on an individual patient by patient basis as caution must be exercised to prevent the presence of too much vitamin d in the body and the various potentially serious toxic effects associated with such circumstances Label.

In particular, the range between therapeutic and toxic doses is quite narrow in vitamin d resistant rickets Label. When high therapeutic doses are used, progress should be followed with frequent blood calcium determinations Label.

When treating hypoparathyroidism, intravenous calcium, parathyroid hormone, and/or dihydrotachysterol may be required Label.

Maintenance of normal serum phosphorus levels by dietary phosphate restriction and/or administration of aluminum gels as intestinal phosphate binders in those patients with hyperphosphatemia as frequently seen in renal osteodystrophy is essential to prevent metastatic calcification Label.

Mineral oil interferes with the absorption of lipid-soluble vitamins, including vitamin d preparations Label.

The administration of thiazide diuretics to hypoparathyroid patients who are concurrently being treated with vitamin d can result in hypercalcemia Label.

At this time, no long term animal studies have been performed to evaluate vitamin potential for carcinogens, mutagenesis, or fertility Label.

As various animal reproduction studies have demonstrated fetal abnormalities in several species associated with hypervitaminosis D, the use of vitamin d in excess of the recommended dietary allowance during normal pregnancy should be avoided Label. The safety in excess of 400 USP units of vitamin d daily during pregnancy has not been established Label. The abnormalities observed are similar to the supravalvular aortic stenosis syndrome described in infants that is characterized by supravalvular aortic stenosis, elfin facies, and mental retardation Label.

In a nursing mother given large doses of vitamin D, 25-hydroxycholecalciferol appeared in the milk and caused hypercalcemia in her child. Caution is subsequently required when contemplating the use of vitamin d in a nursing woman, and the necessity of monitoring infants' serum calcium concentration if vitamin d is administered to a breastfeeding woman Label.

Adverse reactions associated with the use of vitamin d are primarily linked to having hypervitaminosis D occurring [FDA Lanel]. In particular, hypervitaminosis D is characterized by effects specific effects on specific organ systems. At the renal system, hypervitaminosis D can cause impairment of renal function with polyuria, nocturne, polydipsia, hypercalciuria, reversible asotemia, hypertension, nephrocalcinosis, generalized vascular calcification, or even irreversible renal insufficiency which may result in death Label. Elsewhere, hypervitaminosis D can also cause CNS mental retardation Label. At the level of soft tissues, it can widespread calcification of the soft tissues, including the heart, blood vessels, renal tubules, and lungs Label. In the skeletal system, bone demineralization (osteoporosis) in adults can occur while a decline in the average rate of linear growth and increased mineralization of bones, dwarfism, vague aches, stiffness, and weakness can occur in infants and children Label. Finally, hypervitaminosis D can also lead to nausea, anorexia, and constipation at the gastrointestinal level as well as mild acidosis, anemia, or weight loss via metabolic processes Label.

The LD(50) in animals is unknown Label.

Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
1alpha-Hydroxyvitamin D5The risk or severity of adverse effects can be increased when Vitamin D is combined with 1alpha-Hydroxyvitamin D5.
1alpha,24S-Dihydroxyvitamin D2The risk or severity of adverse effects can be increased when 1alpha,24S-Dihydroxyvitamin D2 is combined with Vitamin D.
4-hydroxycoumarinThe metabolism of 4-hydroxycoumarin can be decreased when combined with Vitamin D.
6-Deoxyerythronolide BThe metabolism of Vitamin D can be decreased when combined with 6-Deoxyerythronolide B.
7-ethyl-10-hydroxycamptothecinThe metabolism of Vitamin D can be decreased when combined with 7-ethyl-10-hydroxycamptothecin.
9-aminocamptothecinThe metabolism of 9-aminocamptothecin can be decreased when combined with Vitamin D.
AbataceptThe metabolism of Vitamin D can be increased when combined with Abatacept.
AcalabrutinibThe metabolism of Vitamin D can be decreased when combined with Acalabrutinib.
AcenocoumarolThe metabolism of Acenocoumarol can be decreased when combined with Vitamin D.
AcetaminophenThe metabolism of Vitamin D can be increased when combined with Acetaminophen.
Additional Data Available
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    Extended Description

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    Severity

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  • Evidence Level
    Evidence Level

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  • Action
    Action

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Food Interactions
Not Available

References

General References
  1. Armas LA, Hollis BW, Heaney RP: Vitamin D2 is much less effective than vitamin D3 in humans. J Clin Endocrinol Metab. 2004 Nov;89(11):5387-91. [PubMed:15531486]
  2. DeLuca HF: Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr. 2004 Dec;80(6 Suppl):1689S-96S. [PubMed:15585789]
  3. DeLuca HF: Metabolism of vitamin D: current status. Am J Clin Nutr. 1976 Nov;29(11):1258-70. [PubMed:187053]
  4. Jones KS, Assar S, Harnpanich D, Bouillon R, Lambrechts D, Prentice A, Schoenmakers I: 25(OH)D2 half-life is shorter than 25(OH)D3 half-life and is influenced by DBP concentration and genotype. J Clin Endocrinol Metab. 2014 Sep;99(9):3373-81. doi: 10.1210/jc.2014-1714. Epub 2014 Jun 2. [PubMed:24885631]
  5. 2. (1984). In Vitamin D: Basic and Clinical Aspects (pp. 81). Martinus Nijhoff Publishing. [ISBN:978-1-4612-9793-2]
  6. Vitamin D Wikipedia Entry [Link]
  7. Vitamin D Supplementation: An Update [Link]
External Links
PubChem Substance
347911113
Wikipedia
Vitamin_D
AHFS Codes
  • 88:16.00 — Vitamin D
FDA label
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Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0Active Not RecruitingTreatmentSeasonal Mood Disorder1
0CompletedPreventionDeficiency, Vitamin D1
0CompletedSupportive CareNeoplasms, Breast1
0CompletedTreatmentChronic Kidney Disease (CKD)1
0Not Yet RecruitingTreatmentCrohn's Disease (CD) / Deficiency, Vitamin D1
0Not Yet RecruitingTreatmentPsoriasis Vulgaris (Plaque Psoriasis)1
0RecruitingPreventionDeficiency, Vitamin D1
0RecruitingPreventionVitamin D Intake in First Trimester and Incidence of Gestational Diabetes Recurrence1
0RecruitingTreatmentDeficiency, Vitamin D / Fat malabsorption1
0RecruitingTreatmentErgocalciferol1
1Active Not RecruitingTreatmentSarcopenia1
1Active Not RecruitingTreatmentType 1 Insulin-Dependent Diabetes Mellitus1
1CompletedNot AvailableIrritation1
1CompletedBasic ScienceInsulin Sensitivity1
1CompletedDiagnosticHyperparathyroidism1
1CompletedDiagnosticOsteoporosis1
1CompletedHealth Services ResearchDeficiency, Vitamin D1
1CompletedPreventionBreast Cancer Prevention / Mammographic Density1
1CompletedPreventionGastrointestinal Cancers / High Blood Pressure (Hypertension) / Prostate Cancer1
1CompletedPreventionPhysiological Effects of Vitamin D1
1CompletedTreatmentActinic Dermatosis1
1CompletedTreatmentAsthma / Deficiency, Vitamin D1
1CompletedTreatmentDeficiency, Vitamin D1
1CompletedTreatmentImmune Defect / Infants, Premature1
1CompletedTreatmentInfants, Premature / Late-onset Sepsis1
1CompletedTreatmentOsteoporosis1
1CompletedTreatmentPsoriasis Vulgaris (Plaque Psoriasis)1
1CompletedTreatmentRelapsing Remitting Multiple Sclerosis (RRMS)1
1CompletedTreatmentSarcopenia / Strength, Muscle1
1CompletedTreatmentSolid Cancers1
1CompletedTreatmentTumors, Solid1
1CompletedTreatmentType 2 Diabetes Mellitus1
1Not Yet RecruitingTreatmentRecurrent Respiratory Papillomatosis1
1RecruitingTreatmentCancer of the Pancreas / Malignant Neoplasm of Pancreas1
1RecruitingTreatmentDeficiency, Vitamin D1
1TerminatedTreatmentFrail Elderly1
1WithdrawnOtherHepatocellular,Carcinoma / Liver Cirrhosis1
1, 2Active Not RecruitingTreatmentSmith-Magenis Syndrome1
1, 2CompletedPreventionBiomarker Change Linked to Breast Cancer1
1, 2CompletedPreventionBreast Cancer1
1, 2CompletedPreventionHematopoietic Stem Cell Transplantation (HSCT)1
1, 2CompletedPreventionPrimary Immune Deficiency Disorders (PIDD)1
1, 2CompletedTreatmentColorectal Cancers1
1, 2CompletedTreatmentSickle Cell Disorders1
1, 2RecruitingTreatmentDiabetes Mellitus (DM) / Diabetes, Autoimmune / Hypoglycemia / Type 1 Insulin-Dependent Diabetes Mellitus1
1, 2SuspendedTreatmentDeficiency, Vitamin D / Orthopedic Disorders / Polytrauma1
1, 2TerminatedTreatmentBone Diseases / Breast Cancer1
1, 2WithdrawnTreatmentUlcerative Colitis1
2Active Not RecruitingTreatmentBreast Cancer1
2CompletedNot AvailableDeficiency, Vitamin D / Human Immunodeficiency Virus (HIV) / Human Immunodeficiency Virus (HIV) Infections1
2CompletedOtherHuman Immunodeficiency Virus (HIV)1
2CompletedPreventionCommunity-dwelling Seniors / History of a Fall in the Previous 12 Months1
2CompletedPreventionDeficiency, Vitamin D / High Blood Pressure (Hypertension)1
2CompletedPreventionMigraine1
2CompletedPreventionRespiratory Tract Infections (RTI) / Vitamin D1
2CompletedTreatmentAdult Women / Estrogen Receptor Positive / Metastatic Breast Cancer (MBC)1
2CompletedTreatmentAllergic Rhinoconjunctivitis1
2CompletedTreatmentAutism, Early Infantile1
2CompletedTreatmentBone Loss / Osteoporosis / Spinal Cord Injuries (SCI)1
2CompletedTreatmentBreast Cancer2
2CompletedTreatmentBronchiolitis1
2CompletedTreatmentChronic Heart Failure (CHF)1
2CompletedTreatmentChronic Hepatitis C Virus (HCV) Infection1
2CompletedTreatmentColorectal Cancers1
2CompletedTreatmentDeficiency, Vitamin D1
2CompletedTreatmentDeficiency, Vitamin D / Human Immunodeficiency Virus (HIV) / Hyperparathyroidism / Hypovitaminosis D1
2CompletedTreatmentEarly Stage Breast Cancer1
2CompletedTreatmentEvaluation of Expected Bone Loss After Bariatric Surgery / Possible Prevention of Bone Loss After Surgery by Calcium and Vitamin D Supplementation1
2CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections2
2CompletedTreatmentInsulin Resistance1
2CompletedTreatmentOsteoporosis2
2CompletedTreatmentPolycystic Ovarian Syndrome1
2CompletedTreatmentPulmonary Tuberculosis (TB)1
2CompletedTreatmentType 1 Insulin-Dependent Diabetes Mellitus2
2CompletedTreatmentType 2 Diabetes Mellitus1
2CompletedTreatmentParathyroid deficiency1
2Not Yet RecruitingTreatmentDeficiency, Vitamin D / Infertilities / Infertility, Female1
2RecruitingPreventionNeurofibromatosis Type 1 (NF1)1
2RecruitingPreventionOsteopenia / Osteoporosis1
2RecruitingSupportive CareChronic Obstructive Pulmonary Disease (COPD)1
2RecruitingTreatmentBone Metabolism / Primary Hyperparathyroidism1
2RecruitingTreatmentBreast Cancer1
2RecruitingTreatmentCervical Cancers / Endometrial Cancers / Uterine Malignancies1
2RecruitingTreatmentDeficiency, Vitamin D1
2RecruitingTreatmentDeficiency, Vitamin D / Neurocognitive Dysfunction1
2RecruitingTreatmentLeukemia Acute Myeloid Leukemia (AML)1
2RecruitingTreatmentOptic Neuritis1
2RecruitingTreatmentOsteoporosis2
2RecruitingTreatmentOsteoporosis / Rheumatoid Arthritis1
2TerminatedBasic ScienceBreast Cancer1
2TerminatedPreventionD Vitamin Deficiency Patients1
2TerminatedTreatmentDisseminated Sclerosis1
2TerminatedTreatmentPrimary Breast Cancer1
2TerminatedTreatmentProstate Cancer1
2TerminatedTreatmentSystemic Lupus Erythematosus (SLE)1
2Unknown StatusPreventionSickle Cell Disorders1
2Unknown StatusTreatmentAdvanced Intrahepatic Cholangiocarcinoma1
2Unknown StatusTreatmentDeficiency, Vitamin D / Hepatitis C Infection1
2Unknown StatusTreatmentHypovitaminosis D / Type 2 Diabetes Mellitus1
2Unknown StatusTreatmentObstructive Sleep Apnea-hypopnea Syndrome1
2Unknown StatusTreatmentOptic Neuritis1
2Unknown StatusTreatmentPeritoneal dialysis therapy1
2WithdrawnTreatmentAsthma1
2WithdrawnTreatmentSchizoaffective Disorders / Schizophrenic Disorders1
2, 3Active Not RecruitingPreventionProstate Cancer1
2, 3CompletedPreventionImpaired Glucose Tolerance1
2, 3CompletedSupportive CareType 1 Insulin-Dependent Diabetes Mellitus1
2, 3CompletedTreatmentAcne Vulgaris1
2, 3CompletedTreatmentAllergic Bronchopulmonary Aspergilloses1
2, 3CompletedTreatmentAutism, Early Infantile / Deficiency, Vitamin D1
2, 3CompletedTreatmentCalcifications, Vascular / Deficiency, Vitamin D / Hemodialysis Complication1
2, 3CompletedTreatmentDeficiency, Vitamin D / Hypercalcemia / Primary Hyperparathyroidism1
2, 3CompletedTreatmentHIV test positive / Human Immunodeficiency Virus (HIV) Infections1
2, 3CompletedTreatmentMale Infertility1
2, 3Not Yet RecruitingTreatmentRestless Legs Syndrome (RLS)1
2, 3RecruitingPreventionEnd Stage Renal Disease (ESRD)1
2, 3RecruitingTreatmentAllergies1
2, 3RecruitingTreatmentType 1 Insulin-Dependent Diabetes Mellitus1
2, 3Unknown StatusTreatmentCrohns Disease1
2, 3WithdrawnTreatmentCalcium Nephrolithiasis / Deficiency, Vitamin D1
3Active Not RecruitingPreventionCardiovascular Disease (CVD) / Fracture Bone / Malignancies1
3Active Not RecruitingPreventionHeart Failure1
3Active Not RecruitingTreatmentOsteoporosis1
3CompletedDiagnosticCKD Stage 3/41
3CompletedHealth Services ResearchDeficiency, Vitamin D1
3CompletedHealth Services ResearchType 1 Insulin-Dependent Diabetes Mellitus1
3CompletedPreventionAsthma / Avitaminosis / Respiratory Tract Infections (RTI)1
3CompletedPreventionBone Diseases / Cardiovascular Disease (CVD) / Colonic Neoplasms / Coronary Heart Disease (CHD) / Heart Diseases / Myocardial Ischemia / Neoplasms, Breast / One to five years postmenopausal / Osteoporosis1
3CompletedPreventionGiant Cells Arteritis / Granulomatosis With Polyangiitis / Polymyalgia Rheumatica / Polymyositis / Rheumatoid Arthritis1
3CompletedPreventionHypovitaminosis D1
3CompletedPreventionMigraine According to International Headache Society (IHS) Criteria (ICHD-II)1
3CompletedPreventionOsteopenia / Osteoporosis1
3CompletedPreventionOsteoporosis1
3CompletedPreventionRisperidone-induced Hyperprolactinemia1
3CompletedPreventionVitamin D Status During Pregnancy / Vitamin D3 Deficiency1
3CompletedSupportive CareBreast Cancer / Osteoporosis1
3CompletedTreatmentAcute Lymphoblastic Leukaemias (ALL) / Osteoporosis1
3CompletedTreatmentAcute Respiratory Distress Syndrome (ARDS) / Critical Illness / Deficiency, Vitamin D1
3CompletedTreatmentAlzheimer's Disease (AD)1
3CompletedTreatmentBreast Cancer1
3CompletedTreatmentCKd Patients With Stage 3 and 41
3CompletedTreatmentDeficiency, Vitamin D1
3CompletedTreatmentDeficiency, Vitamin D / Heart Failure1
3CompletedTreatmentDiabetes Mellitus (DM) / Insulin Resistance / Low-intensity Chronic Inflammation1
3CompletedTreatmentHypovitaminosis D1
3CompletedTreatmentKnee Osteoarthritis (Knee OA)1
3CompletedTreatmentMalignant Lymphomas / Non-Hodgkin's Lymphoma (NHL)1
3CompletedTreatmentNAFLD / Non Alcoholic Steatohepatitis (NASH)1
3CompletedTreatmentOsteoporosis2
3CompletedTreatmentPaget's Disease of Bone1
3CompletedTreatmentPostmenopausal Osteoporosis (PMO)1
3CompletedTreatmentPremature Ejaculation1
3CompletedTreatmentProteinuria / Renal Insufficiency,Chronic1
3CompletedTreatmentSmear Positive Pulmonary Tuberculosis1
3CompletedTreatmentType 2 Diabetes Mellitus1
3CompletedTreatmentX-Linked Hypophosphatemia1
3Not Yet RecruitingTreatmentCritical Illness / Deficiency, Vitamin D / Sarcopenia1
3Not Yet RecruitingTreatmentDeficiency, Vitamin D1
3Not Yet RecruitingTreatmentSchizophrenic Disorders1
3RecruitingPreventionDeficiency, Vitamin D / Epilepsies1
3RecruitingPreventionDisseminated Sclerosis1
3RecruitingTreatmentChronic Rhinosinusitis With Nasal Polyps1
3RecruitingTreatmentCutaneous Malignant Melanoma1
3RecruitingTreatmentDeficiency, Vitamin D1
3RecruitingTreatmentDiabetic Nephropathies1
3RecruitingTreatmentMyocardial Infarction1
3RecruitingTreatmentOvulation induction therapy1
3TerminatedPreventionPolymorphic Light Eruption (PLE)1
3TerminatedTreatmentChronic Hepatitis C Virus (HCV) Infection1
3TerminatedTreatmentCoronary Artery Disease / Deficiency, Vitamin D / Hyperglycemia, Postprandial1
3TerminatedTreatmentFracture of Neck of Femur1
3Unknown StatusPreventionDeficiency, Vitamin D / Pneumonia1
3Unknown StatusPreventionFalls / Fracture Bone1
3Unknown StatusTreatmentChronic Hepatitis C Virus (HCV) Infection1
3Unknown StatusTreatmentDisseminated Sclerosis1
3Unknown StatusTreatmentNon.Alcoholic Fatty Liver Disease1
3Unknown StatusTreatmentOsteoporosis1
3Unknown StatusTreatmentTuberculosis Infection1
3WithdrawnTreatmentChronic Hepatitis C Virus (HCV) Infection1
3WithdrawnTreatmentMinor burns1
4Active Not RecruitingOtherPatient Adherence1
4Active Not RecruitingPreventionHypocalcemia1
4CompletedNot AvailableOsteopenia1
4CompletedBasic ScienceDeficiency, Vitamin D2
4CompletedOtherChronic Kidney Disease (CKD) / Glomerulonephritis minimal lesion / Transplantation, Renal1
4CompletedPreventionAllergies / Wheezing1
4CompletedPreventionAllograft Rejection / Obliterative Bronchiolitis / Transplantation, Lung1
4CompletedPreventionBMI >27 kg/m2 / BMI >30 kg/m2 / Insulin Resistance1
4CompletedPreventionBenign Paroxysmal Positional Vertigo (BPPV)1
4CompletedPreventionCrohn's Disease (CD)1
4CompletedPreventionDeficiency, Vitamin D2
4CompletedPreventionDeficiency, Vitamin D / Type 2 Diabetes Mellitus1
4CompletedPreventionType 1 Insulin-Dependent Diabetes Mellitus1
4CompletedScreeningDeficiency, Vitamin D / Hyperparathyroidism, Secondary / Osteomalacia1
4CompletedTreatmentAsthma1
4CompletedTreatmentBMI >30 kg/m21
4CompletedTreatmentBMI >30 kg/m2 / Deficiency, Vitamin D1
4CompletedTreatmentBMI >30 kg/m2 / Insulin Resistance1
4CompletedTreatmentCalcification / Calcifications, Vascular / Cardiovascular Disease (CVD) / Chronic Kidney Disease (CKD) / Chronic Renal Failure (CRF) / Coronary Artery Calcifications / End Stage Renal Disease (ESRD) / Hyperparathyroidism / Hyperparathyroidism, Secondary / Kidney Diseases / Nephrology1
4CompletedTreatmentChronic Heart Failure (CHF) / Deficiency, Vitamin D1
4CompletedTreatmentChronic Kidney Disease (CKD) / Deficiency, Vitamin D1
4CompletedTreatmentChronic Kidney Disease (CKD) / Hyperparathyroidism, Secondary1
4CompletedTreatmentCongestive Heart Failure1
4CompletedTreatmentDeficiency, Vitamin D3
4CompletedTreatmentDeficiency, Vitamin D / Healthy Volunteers / Polycystic Ovaries Syndrome1
4CompletedTreatmentDeficiency, Vitamin D / Heart Failure1
4CompletedTreatmentDeficiency, Vitamin D / Hypercalcemia / Hypercalciuria / Osteopenia / Osteoporosis / Parathyroid deficiency1
4CompletedTreatmentDeficiency, Vitamin D / Non-Alcoholic Fatty Liver Disease (NAFLD)1
4CompletedTreatmentDeficiency, Vitamin D / Polycystic Ovaries Syndrome1
4CompletedTreatmentDeficiency, Vitamin D / Relapsing Remitting Multiple Sclerosis (RRMS)1
4CompletedTreatmentEnd Stage Kidney Disease1
4CompletedTreatmentHip Fractures1
4CompletedTreatmentHyperparathyroidism, Secondary2
4CompletedTreatmentHypogonadism1
4CompletedTreatmentNutritional Rickets1
4CompletedTreatmentOsteopenia / Osteoporosis / Primary Hyperparathyroidism1
4CompletedTreatmentOsteoporosis2
4CompletedTreatmentPityriasis Alba1
4CompletedTreatmentPostmenopausal Osteoporosis (PMO)3
4Enrolling by InvitationPreventionBariatric Surgery Candidate1
4Enrolling by InvitationTreatmentGestational Diabetes Mellitus (GDM)1
4Not Yet RecruitingPreventionHepatocellular,Carcinoma / Viral Hepatitis B1
4Not Yet RecruitingTreatmentAcne Vulgaris1
4Not Yet RecruitingTreatmentAlopecia Areata (AA) / Fractional Carbon Dioxide Laser1
4Not Yet RecruitingTreatmentPsoriasis1
4RecruitingPreventionEclampsia / Gestational Hypertension / HELLP Syndrome / Superimposed Preeclampsia / Toxemia1
4RecruitingPreventionFood Allergy1
4RecruitingTreatmentAnemias1
4RecruitingTreatmentAtopic Dermatitis (AD)1
4RecruitingTreatmentBMI >30 kg/m21
4RecruitingTreatmentBronchiectasis1
4RecruitingTreatmentChronic Renal Failure (CRF) / Renal Insufficiency,Chronic1
4RecruitingTreatmentDeficiency, Vitamin D / Depression / Insulin Resistance / Polycystic Ovarian Syndrome1
4RecruitingTreatmentDeficiency, Vitamin D / Hip Fractures1
4RecruitingTreatmentInfertilities1
4RecruitingTreatmentMyopathic Symptoms1
4RecruitingTreatmentPolycystic Ovarian Syndrome1
4RecruitingTreatmentPolycystic Ovaries Syndrome1
4RecruitingTreatmentPostoperative pain1
4SuspendedTreatmentAdynamic Bone Disease / Deficiency, Vitamin D / Hyperparathyroidism, Secondary / Renal Disease Bone / Renal Disease, End Stage / Restless Legs Syndrome (RLS)1
4TerminatedTreatmentChronic Hepatitis C Virus (HCV) Infection / Flaviviridae Infections / Hepatitis C Viral Infection / RNA Virus Infections1
4TerminatedTreatmentCrohn's Disease (CD) / Deficiency, Vitamin D1
4TerminatedTreatmentHeart Failure1
4TerminatedTreatmentPeripheral Arterial Disease (PAD)1
4Unknown StatusBasic ScienceAcute Coronary Syndromes (ACS) / Cytokines1
4Unknown StatusPreventionBMI >30 kg/m2 / Insulin Resistance / Vitamin D25 Insufficiency1
4Unknown StatusPreventionCoronary Artery Calcifications / Kidney Diseases1
4Unknown StatusSupportive CareEndometriosis1
4Unknown StatusTreatmentAcute Lower Respiratory Tract Infection / Bronchiolitis / Pneumonia1
4Unknown StatusTreatmentChronic Pain Syndrome / Deficiency, Vitamin D / Inflammatory Responses1
4Unknown StatusTreatmentDeficiency, Vitamin D / Diabetes Mellitus (DM)1
4Unknown StatusTreatmentDisseminated Sclerosis1
4Unknown StatusTreatmentHyperparathyroidism, Secondary1
4Unknown StatusTreatmentMetabolic Syndromes1
4Unknown StatusTreatmentPersistent Asthma1
Not AvailableActive Not RecruitingTreatmentAsthma / Deficiency, Vitamin D1
Not AvailableActive Not RecruitingTreatmentFemale Sexual Dysfunction (FSD) / Polycystic Ovaries Syndrome1
Not AvailableCompletedNot AvailableAsthma / Deficiency, Vitamin D1
Not AvailableCompletedNot AvailableCardiovascular Disease (CVD)1
Not AvailableCompletedNot AvailableDeficiency, Vitamin D / Osteopenia / Osteoporosis1
Not AvailableCompletedNot AvailableHMG COA Reductase Inhibitor Adverse Reaction1
Not AvailableCompletedNot AvailableType 1 Insulin-Dependent Diabetes Mellitus1
Not AvailableCompletedNot AvailableWilliams Syndrome1
Not AvailableCompletedBasic ScienceBlood Pressures / BMI >27 kg/m2 / BMI >30 kg/m2 / Endothelial Function / Renal Function1
Not AvailableCompletedDiagnosticVitamin D Status1
Not AvailableCompletedPreventionBMI >30 kg/m2 / Diabetes Mellitus, Non-Insulin-Dependent1
Not AvailableCompletedPreventionBlood Platelet Disorders / Deficiency, Vitamin D1
Not AvailableCompletedPreventionDeficiency, Vitamin D1
Not AvailableCompletedPreventionDeficiency, Vitamin D / Muscle Weakness1
Not AvailableCompletedPreventionDiabetes Mellitus, Non-Insulin-Dependent1
Not AvailableCompletedPreventionEnd Stage Renal Disease (ESRD)1
Not AvailableCompletedPreventionFalls Prevention / Mild Cognitive Impairment (MCI) / Mild Dementia1
Not AvailableCompletedPreventionMalignant Melanoma of Skin1
Not AvailableCompletedPreventionOsteoporosis2
Not AvailableCompletedPreventionPre-Diabetic1
Not AvailableCompletedPreventionPregnancy1
Not AvailableCompletedPreventionSarcopenia1
Not AvailableCompletedSupportive CareDiabetic Neuropathies1
Not AvailableCompletedSupportive CarePulmonary Tuberculosis (TB)1
Not AvailableCompletedTreatmentAtherosclerosis / Leukocyte Activation Disorder / Oxidative Stress1
Not AvailableCompletedTreatmentAtopic Dermatitis (AD)1
Not AvailableCompletedTreatmentBMI >30 kg/m21
Not AvailableCompletedTreatmentBMI >30 kg/m2 / Deficiency, Vitamin D / Psychosis / Schizoaffective Disorders / Schizophrenic Disorders1
Not AvailableCompletedTreatmentBack Pain, Unspecified / Hypovitaminosis D1
Not AvailableCompletedTreatmentCardiovascular Disease (CVD) / Deficiency, Vitamin D / High Blood Pressure (Hypertension) / Insulin Resistance / Type 2 Diabetes Mellitus1
Not AvailableCompletedTreatmentChildren With Down Syndrome1
Not AvailableCompletedTreatmentChronic Obstructive Pulmonary Disease (COPD)1
Not AvailableCompletedTreatmentClozapine Resistant Schizophrenia1
Not AvailableCompletedTreatmentDeficiency of Vitamin D3 / Gingival and Periodontal Disease / Pregnancy1
Not AvailableCompletedTreatmentDeficiency, Vitamin D6
Not AvailableCompletedTreatmentDeficiency, Vitamin D / End-Stage Renal Disease (ESRD)1
Not AvailableCompletedTreatmentDeficiency, Vitamin D / Healthy Volunteers1
Not AvailableCompletedTreatmentDeficiency, Vitamin D / Osteoporosis1
Not AvailableCompletedTreatmentDeficiency, Vitamin D / Polycystic Ovarian Syndrome1
Not AvailableCompletedTreatmentDiabetes Mellitus (DM)1
Not AvailableCompletedTreatmentDisorders of Parathyroid Gland / Hyperparathyroidism1
Not AvailableCompletedTreatmentEnd-Stage Renal Disease (ESRD)1
Not AvailableCompletedTreatmentHIV Seropositive1
Not AvailableCompletedTreatmentHIV-associated Co-morbidities1
Not AvailableCompletedTreatmentHeart Failure1
Not AvailableCompletedTreatmentImpaired Renal Function1
Not AvailableCompletedTreatmentNeoplasms, Brain2
Not AvailableCompletedTreatmentPsoriasis Vulgaris (Plaque Psoriasis)1
Not AvailableCompletedTreatmentSystemic Lupus Erythematosus (SLE)1
Not AvailableCompletedTreatmentTransplant Bone Disease1
Not AvailableCompletedTreatmentType 2 Diabetes Mellitus1
Not AvailableCompletedTreatmentVitamin D Supplementation1
Not AvailableNot Yet RecruitingPreventionTransient Hypercalciuria1
Not AvailableNot Yet RecruitingTreatmentAssisted Reproductive Technology therapy / Polycystic Ovaries Syndrome1
Not AvailableNot Yet RecruitingTreatmentDeficiency, Vitamin D / Gynaecological Disease1
Not AvailableNot Yet RecruitingTreatmentDevelopment, Child1
Not AvailableNot Yet RecruitingTreatmentPregnancy Early1
Not AvailableRecruitingNot AvailableAlzheimer's Disease (AD) / Gait Apraxia / Impaired Cognition1
Not AvailableRecruitingNot AvailableOsteoporosis,Neurological Disorders1
Not AvailableRecruitingPreventionBone Density1
Not AvailableRecruitingPreventionBurn Surgery1
Not AvailableRecruitingSupportive CareHematopoietic Stem Cell Transplant (HSCT)1
Not AvailableRecruitingSupportive CareHyperparathyroidism, Secondary1
Not AvailableRecruitingTreatmentBMI >30 kg/m21
Not AvailableRecruitingTreatmentDeficiency, Vitamin D1
Not AvailableRecruitingTreatmentDeficiency, Vitamin D / Impaired Glucose Tolerance / Insulin Resistance / Oxidative Stress1
Not AvailableRecruitingTreatmentDeficiency, Vitamin D / Psoriasis1
Not AvailableRecruitingTreatmentHyperparathyroidism, Secondary / Maintenance Hemodialysis1
Not AvailableRecruitingTreatmentLiver Diseases1
Not AvailableRecruitingTreatmentPeripheral Arterial Disease (PAD)1
Not AvailableRecruitingTreatmentProphylaxis of Contrast-induced nephropathy1
Not AvailableTerminatedNot AvailableFractures, Bone / Kidney Diseases / Muscle Weakness / Pain1
Not AvailableTerminatedTreatmentAtopic Dermatitis (AD) / Deficiency, Vitamin D1
Not AvailableTerminatedTreatmentDeficiency, Vitamin D1
Not AvailableTerminatedTreatmentLeg Cramps, Nocturnal / Muscle Cramps1
Not AvailableUnknown StatusNot AvailableChronic Hepatitis C Virus (HCV) Infection1
Not AvailableUnknown StatusTreatmentChronic Hepatitis C Virus (HCV) Infection1
Not AvailableUnknown StatusTreatmentChronic Musculoskeletal Pain / Vitamin D Supplementation1
Not AvailableUnknown StatusTreatmentDeficiency, Vitamin D1
Not AvailableUnknown StatusTreatmentDeficiency, Vitamin D / Hepatocellular,Carcinoma1
Not AvailableUnknown StatusTreatmentDeficiency, Vitamin D / Rheumatoid Arthritis1
Not AvailableUnknown StatusTreatmentDyslipidemia (Fredrickson Type Ⅱa)1
Not AvailableUnknown StatusTreatmentHepatitis B Virus (HBV)1
Not AvailableUnknown StatusTreatmentHepatitis C Viral Infection1
Not AvailableUnknown StatusTreatmentImpaired Glucose Tolerance / Insulin Resistance1
Not AvailableUnknown StatusTreatmentNon-Alcoholic Fatty Liver Disease (NAFLD)1
Not AvailableUnknown StatusTreatmentProstatic Neoplasms1
Not AvailableWithdrawnPreventionHypocalcemia1
Not AvailableWithdrawnTreatmentChronic Kidney Disease (CKD) / Deficiency, Vitamin D1
Not AvailableWithdrawnTreatmentChronic Rhinosinusitis1
Not AvailableWithdrawnTreatmentHMG COA Reductase Inhibitor Adverse Reaction1
Not AvailableWithdrawnTreatmentHigh Blood Pressure (Hypertension)1
Not AvailableWithdrawnTreatmentInflammatory Bowel Diseases (IBD) / Ulcerative Colitis1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
OintmentTopical
ElixirOral
CreamTopical
WaferOral
LozengeOral
Solution / dropsOral
LiquidIntravenous
SolutionIntravenous
Liquid; tabletOral
LiquidOral
Tablet, chewableOral
KitOral
CapsuleOral
TabletOral
LiquidOral
Capsule, gelatin coatedOral
Tablet, coatedOral
Tablet, extended releaseOral
Capsule; liquidOral
SolutionOral
CapsuleOral
Capsule, liquid filledOral
TabletOral400 unit
TabletOral
PowderOral
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
Not Available
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Targets

Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Zinc ion binding
Specific Function
Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Recruited to promoters via its interaction with BAZ1B...
Gene Name
VDR
Uniprot ID
P11473
Uniprot Name
Vitamin D3 receptor
Molecular Weight
48288.64 Da
References
  1. Choi M, Yamada S, Makishima M: Dynamic and ligand-selective interactions of vitamin D receptor with retinoid X receptor and cofactors in living cells. Mol Pharmacol. 2011 Dec;80(6):1147-55. doi: 10.1124/mol.111.074138. Epub 2011 Sep 14. [PubMed:21917910]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Vitamin transporter activity
Specific Function
Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.
Gene Name
GC
Uniprot ID
P02774
Uniprot Name
Vitamin D-binding protein
Molecular Weight
52963.025 Da
References
  1. Arnaud J, Constans J: Affinity differences for vitamin D metabolites associated with the genetic isoforms of the human serum carrier protein (DBP). Hum Genet. 1993 Sep;92(2):183-8. [PubMed:8370586]

Enzymes

Kind
Protein
Organism
Humans
Pharmacological action
Yes
Actions
Substrate
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3).
Gene Name
CYP2R1
Uniprot ID
Q6VVX0
Uniprot Name
Vitamin D 25-hydroxylase
Molecular Weight
57358.82 Da
References
  1. DeLuca HF: Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr. 2004 Dec;80(6 Suppl):1689S-96S. [PubMed:15585789]
  2. Armas LA, Hollis BW, Heaney RP: Vitamin D2 is much less effective than vitamin D3 in humans. J Clin Endocrinol Metab. 2004 Nov;89(11):5387-91. [PubMed:15531486]
  3. DeLuca HF: Metabolism of vitamin D: current status. Am J Clin Nutr. 1976 Nov;29(11):1258-70. [PubMed:187053]
Kind
Protein
Organism
Humans
Pharmacological action
Yes
Actions
Substrate
General Function
Iron ion binding
Specific Function
Catalyzes the conversion of 25-hydroxyvitamin D3 (25(OH)D) to 1-alpha,25-dihydroxyvitamin D3 (1,25(OH)2D) plays an important role in normal bone growth, calcium metabolism, and tissue differentiation.
Gene Name
CYP27B1
Uniprot ID
O15528
Uniprot Name
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
Molecular Weight
56503.475 Da
References
  1. DeLuca HF: Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr. 2004 Dec;80(6 Suppl):1689S-96S. [PubMed:15585789]
  2. DeLuca HF: Metabolism of vitamin D: current status. Am J Clin Nutr. 1976 Nov;29(11):1258-70. [PubMed:187053]
  3. Armas LA, Hollis BW, Heaney RP: Vitamin D2 is much less effective than vitamin D3 in humans. J Clin Endocrinol Metab. 2004 Nov;89(11):5387-91. [PubMed:15531486]
Kind
Protein
Organism
Humans
Pharmacological action
No
Actions
Substrate
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Griffin J. and D'Arcy P. (1997). A manual of adverse drug interactions (5th ed.). Elsevier. [ISBN:0-444-82406-5]

Drug created on December 03, 2015 09:51 / Updated on November 13, 2019 18:22