Identification

Name
Cholecalciferol
Accession Number
DB00169  (NUTR00008, APRD00506)
Type
Small Molecule
Groups
Approved, Nutraceutical
Description

Derivative of 7-dehydroxycholesterol formed by ultraviolet rays breaking of the C9-C10 bond. It differs from ergocalciferol in having a single bond between C22 and C23 and lacking a methyl group at C24.

Structure
Thumb
Synonyms
  • (+)-vitamin D3
  • (1S,3Z)-3-[(2e)-2-[(1R,3AR,7as)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexan-1-ol
  • (3β,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol
  • (5Z,7E)-(3S)-9,10-secocholesta-5,7,10(19)-trien-3-ol
  • Activated 7-dehydrocholesterol
  • Calciol
  • CC
  • Colecalciferol
  • colecalciferolum
  • Oleovitamin D3
  • Vitamin D-3
  • Vitamin D3
External IDs
NSC-375571
Product Images
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Cataplex D Tab 400unitTablet400 unitOralStandard Process Inc.Not applicableNot applicableCanada
D-tabs 10000unitTablet10000 unitOralLaboratoire Riva Inc1992-12-31Not applicableCanada
Euro D 10 000Capsule10000 unitOralEuro Pharm International Canada Inc2017-08-16Not applicableCanada
Euro D 10 000Capsule10000 unitOralSandoz Canada Incorporated2005-04-06Not applicableCanada
Formula 3200 Waf 100unitWafer100 unitOralStandard Process Inc.Not applicableNot applicableCanada
Luxa-DCapsule25000 unitOralOrimed Pharma Corporation2015-07-31Not applicableCanada
Luxa-DCapsule2000 unitOralOrimed Pharma Corporation2015-07-31Not applicableCanada
Luxa-DCapsule5000 unitOralOrimed Pharma Corporation2015-10-20Not applicableCanada
Luxa-DCapsule50000 unitOralOrimed Pharma Corporation2015-10-20Not applicableCanada
VidextraTablet10000 unitOralOrimed Pharma Corporation2014-03-20Not applicableCanada
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Jamp-vitamin DTablet10000 unitOralJamp Pharma Corporation2012-05-02Not applicableCanada
Jamp-vitamin DCapsule25000 unitOralJamp Pharma CorporationNot applicableNot applicableCanada
Jamp-vitamin DCapsule10000 unitOralJamp Pharma Corporation2015-11-20Not applicableCanada
Jamp-vitamin DCapsule5000 unitOralJamp Pharma CorporationNot applicableNot applicableCanada
Jamp-vitamin DCapsule50000 unitOralJamp Pharma Corporation2016-06-23Not applicableCanada
Jamp-vitamin DCapsule2000 unitOralJamp Pharma CorporationNot applicableNot applicableCanada
Pharma-D 10000 IuCapsule10000 unitOralPharmascience Inc2011-08-29Not applicableCanada
Pharma-D 5000 IuCapsule5000 unitOralPharmascience IncNot applicableNot applicableCanada
Pharma-D 50000 IuCapsule50000 unitOralPharmascience Inc2011-08-09Not applicableCanada
Riva-DTablet10000 unitOralLaboratoire Riva IncNot applicableNot applicableCanada
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
D Vi Sol Infants Drops 400unit/0.6mlSolution / drops400 unitOralMead Johnson Nutritionals1985-12-311998-09-28Canada
Vitamin D 1000iuTablet1000 unitOralWn Pharmaceuticals Ltd.1999-07-082007-08-07Canada
Vitamin D 400 IuTablet400 unitOralWn Pharmaceuticals Ltd.2002-03-132007-08-07Canada
Vitamin D 400 Iu TabletsTablet400 unitOralSwiss Herbal Remedies Ltd.1996-12-112009-08-04Canada
Vitamin D-dry 400 I.U.Tablet400 unitOralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
24 Multivitamins + MineralsCholecalciferol (400 unit) + Ascorbic acid (150 mg) + Beta carotene (10000 unit) + Biotin (25 mcg) + Calcium (130 mg) + Choline bitartrate (25 mg) + Chromium (20 mcg) + Copper (1 mg) + Cyanocobalamin (25 mcg) + Ferrous fumarate (15 mg) + Folic Acid (.8 mg) + Inositol (25 mg) + Magnesium (65 mg) + Manganese (2 mg) + Molybdenum (20 mcg) + Niacin (25 mg) + Calcium pantothenate (25 mg) + Potassium (15 mg) + Potassium Iodide (.1 mg) + Pyridoxine hydrochloride (25 mg) + Racemethionine (25 mg) + Riboflavin (25 mg) + Selenium (20 mcg) + Thiamine hydrochloride (25 mg) + Vanadium (20 mcg) + Vitamin A palmitate (5000 unit) + Vitamin E (50 unit) + Zinc (10 mg)TabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1997-04-302002-07-31Canada
50 Plus Multiple Vitamins & MineralsCholecalciferol (400 unit) + Ascorbic acid (90 mg) + Biotin (45 mcg) + Calcium (200 mg) + Chromium (10 mcg) + Copper (2 mg) + Cyanocobalamin (25 mcg) + Folic Acid (0.4 mg) + Magnesium (100 mg) + Manganese (5 mg) + Molybdenum (25 mcg) + Nicotinamide (40 mg) + Pantothenic acid (10 mg) + Potassium Iodide (0.15 mg) + Pyridoxine hydrochloride (3 mg) + Riboflavin (3.2 mg) + Selenium (25 mcg) + Thiamine mononitrate (2.25 mg) + Vanadium (10 mcg) + Vitamin A palmitate (6000 unit) + Zinc (15 mg)TabletOralGfr Pharma Ltd.2002-10-202004-06-15Canada
A + D OintmentCholecalciferol (500 unit) + Vitamin A palmitate (2000 unit)OintmentTopicalNational Care Products Ltd.1993-12-312002-10-10Canada
A.R.T.H. Away FormulaCholecalciferol (45 unit) + Calcium (24 mg) + Copper (0.232 mg) + Folic Acid (0.025 mg) + Manganese (0.58 mg) + Pyridoxine hydrochloride (0.5 mg) + Selenium (1.54 mcg) + Zinc (0.63 mg)CapsuleOralAbundance Marketing Ltd.1999-02-012006-06-16Canada
Aces TabCholecalciferol (200 unit) + Calcium ascorbate (350 mg) + Chromium (25 mcg) + Selenium (100 mcg) + Vitamin A (5000 unit) + Vitamin E (200 unit) + Zinc (25 mg)TabletOralNu Life Nutrition Ltd.1987-12-312005-03-15Canada
Acti-cal/mag 2:1 + Zinc and D CapletCholecalciferol (100 unit) + Calcium (350.0 mg) + Magnesium (175.0 mg) + Zinc (6.0 mg)TabletOralActi Form Ltd.1991-12-312005-03-21Canada
Actical Plus Calcium-magnesium-vitamin D3-silicon ChewableCholecalciferol (100 unit) + Calcium (200 mg) + Magnesium (100 mg) + Silicon (2 mg)TabletOralUsana Health Sciences, Inc.1999-09-302004-07-27Canada
Active Calcium Plus Magnesium, Vitamin D and SiliconCholecalciferol (100 unit) + Calcium (200 mg) + Magnesium (100 mg) + Silicon (2.25 mg)TabletOralUsana Health Sciences, Inc.2002-07-082007-07-18Canada
Actonel Sachet KitCholecalciferol (880 unit) + Calcium (1000 mg) + Risedronate sodium (35 mg)Granule, effervescent; Kit; TabletOralWarner ChilcottNot applicableNot applicableCanada
AdrovanceCholecalciferol (2800 IU) + Alendronate sodium (70 mg)TabletOralMerck Sharp & Dohme B.V.2007-01-04Not applicableEu
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Active FECholecalciferol (400 [iU]/1) + Ascorbic acid (160 mg/1) + Beta carotene (2100 [iU]/1) + Cupric oxide (1 mg/1) + Cyanocobalamin (30 ug/1) + DL-alpha tocopheryl acetate (40 [iU]/1) + Folic Acid (1250 ug/1) + Iron (75 mg/1) + Magnesium oxide (30 mg/1) + Nicotinamide (20 mg/1) + Pyridoxine hydrochloride (20 mg/1) + Riboflavin (4 mg/1) + Thiamine hydrochloride (4 mg/1) + Zinc oxide (20 mg/1)TabletOralGm Pharmaceuticals2013-11-11Not applicableUs
Active OBCholecalciferol (400 [iU]/1) + Ascorbic acid (100 mg/1) + Cupric sulfate pentahydrate (2 mg/1) + Cyanocobalamin (30 ug/1) + D-alpha-Tocopherol acetate (30 [iU]/1) + Doconexent (320 mg/1) + Folic Acid (1 mg/1) + Iron (20 mg/1) + Pyridoxine hydrochloride (20 mg/1) + Riboflavin (4 mg/1) + Thiamine mononitrate (2 mg/1) + Zinc oxide (30 mg/1)Capsule, liquid filledOralGm Pharmaceuticals2013-10-282017-03-31Us
Animi-3Cholecalciferol (1000 [iU]/1) + Cyanocobalamin (500 ug/1) + Doconexent (250 mg/1) + Folic Acid (1 mg/1) + Icosapent (35 mg/1) + Omega-3 fatty acids (500 mg/1) + Pyridoxine hydrochloride (12.5 mg/1) + Soy sterol (200 mg/1)CapsuleOralPbm Pharmaceuticals Inc.2011-06-01Not applicableUs
Animi-3 with Vitamin DCholecalciferol (1000 [iU]/1) + Cyanocobalamin (500 ug/1) + Doconexent (250 mg/1) + Folic Acid (1 mg/1) + Icosapent (35 mg/1) + Omega-3 fatty acids (500 mg/1) + Pyridoxine hydrochloride (12.5 mg/1) + Soy sterol (200 mg/1)CapsuleOralPbm Pharmaceuticals Inc.2011-06-01Not applicableUs
Bal-Care DHACholecalciferol (840 [iU]/1) + Ascorbic acid (120 mg/1) + Beta carotene (2850 [iU]/1) + Calcium Carbonate (219 mg/1) + Cupric oxide (2 mg/1) + Cyanocobalamin (.012 mg/1) + DL-alpha tocopheryl acetate (3 mg/1) + Folic Acid (1 mg/1) + Iodine (.223 mg/1) + Iron saccharate (1.35 mg/1) + Magnesium oxide (25 mg/1) + Nicotinamide (20 mg/1) + Omega-3 fatty acids (430 mg/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (4 mg/1) + Sodium feredetate (25.65 mg/1) + Thiamine mononitrate (1.8 mg/1) + Zinc oxide (25 mg/1)KitPru Gen Pharmaceuticals2012-05-01Not applicableUs
Bal-Care DHA EssentialCholecalciferol (840 [iU]/1) + Ascorbic acid (120 mg/1) + Beta carotene (2850 [iU]/1) + Calcium Carbonate (219 mg/1) + Cupric oxide (2 mg/1) + Cyanocobalamin (.012 mg/1) + DL-alpha tocopheryl acetate (3 mg/1) + Folic Acid (1 mg/1) + Iodine (.223 mg/1) + Iron saccharate (1.35 mg/1) + Magnesium oxide (25 mg/1) + Nicotinamide (20 mg/1) + Omega-3 fatty acids (374 mg/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (4 mg/1) + Sodium feredetate (25.65 mg/1) + Thiamine mononitrate (1.8 mg/1) + Zinc oxide (25 mg/1)KitPru Gen Pharmaceuticals2012-05-01Not applicableUs
C-Nate DHACholecalciferol (400 [iU]/1) + Ascorbic acid (100 mg/1) + Cupric sulfate pentahydrate (1 mg/1) + Cyanocobalamin (15 ug/1) + Ferrous fumarate (28 mg/1) + Folic Acid (1 mg/1) + Magnesium (30 mg/1) + Omega-3 fatty acids (200 mg/1) + Pyridoxine hydrochloride (20 mg/1) + Riboflavin (3 mg/1) + Thiamine mononitrate (3 mg/1) + Vitamin E (30 [iU]/1) + Zinc oxide (20 mg/1)Capsule, gelatin coatedOralCenturion Labs2013-01-01Not applicableUs
Calcium Folic Acid Plus D ChewableCholecalciferol (300 [iU]/1) + Boron (250 ug/1) + Calcium Carbonate (1342 mg/1) + Cyanocobalamin (125 ug/1) + Folic Acid (1 mg/1) + Magnesium (50 mg/1) + Pyridoxine (10 mg/1)WaferOralAcella Pharmaceuticals, LLC2009-03-20Not applicableUs
Cavan AlphaCholecalciferol (800 [iU]/1) + Ascorbic acid (120 mg/1) + Beta carotene (3000 [iU]/1) + Calcium Carbonate (230 mg/1) + Cupric oxide (2 mg/1) + Cyanocobalamin (12 ug/1) + DL-alpha tocopheryl acetate (3 mg/1) + Folic Acid (1 mg/1) + Iodine (220 ug/1) + Iron (27 mg/1) + Magnesium oxide (25 mg/1) + Nicotinamide (20 mg/1) + Omega-3 fatty acids (300 mg/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (4 mg/1) + Thiamine mononitrate (1.8 mg/1) + Zinc oxide (25 mg/1)KitOralSeton Pharmaceuticals2010-07-012013-09-30Us
Cavan Folate DHACholecalciferol (400 [iU]/1) + Cholecalciferol (400 [iU]/1) + Ascorbic acid (70 mg/1) + Ascorbic acid (70 mg/1) + Beta carotene (2700 [iU]/1) + Beta carotene (2700 [iU]/1) + Calcium Carbonate (100 mg/1) + Calcium Carbonate (100 mg/1) + Cupric oxide (2 mg/1) + Cupric oxide (2 mg/1) + Cyanocobalamin (12 ug/1) + Cyanocobalamin (12 ug/1) + DL-alpha tocopheryl acetate (30 [iU]/1) + DL-alpha tocopheryl acetate (30 [iU]/1) + Doconexent (250 mg/1) + Doconexent (250 mg/1) + Ferrous fumarate (65 mg/1) + Ferrous fumarate (65 mg/1) + Folic Acid (1 mg/1) + Folic Acid (1 mg/1) + Magnesium oxide (25 mg/1) + Magnesium oxide (25 mg/1) + Nicotinamide (18 mg/1) + Nicotinamide (18 mg/1) + Pyridoxine hydrochloride (2.5 mg/1) + Pyridoxine hydrochloride (2.5 mg/1) + Riboflavin (1.8 mg/1) + Riboflavin (1.8 mg/1) + Thiamine mononitrate (1.6 mg/1) + Thiamine mononitrate (1.6 mg/1) + Zinc oxide (25 mg/1) + Zinc oxide (25 mg/1)KitSeton Pharmaceuticals2010-06-042012-03-31Us
International/Other Brands
Delta-D / Micro-D / Optimal-D (RV Nutritional, LLC) / Vigantol
Categories
UNII
1C6V77QF41
CAS number
67-97-0
Weight
Average: 384.6377
Monoisotopic: 384.33921603
Chemical Formula
C27H44O
InChI Key
QYSXJUFSXHHAJI-YRZJJWOYSA-N
InChI
InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
IUPAC Name
(1S,3Z)-3-{2-[(1R,3aS,4E,7aR)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-octahydro-1H-inden-4-ylidene]ethylidene}-4-methylidenecyclohexan-1-ol
SMILES
CC(C)CCC[C@@H](C)[C@@]1([H])CC[C@@]2([H])\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)CCC1=C

Pharmacology

Indication

For the treatment of vitamin D deficiency or insufficiency, refractory rickets (vitamin D resistant rickets), familial hypophosphatemia and hypoparathyroidism, and in the management of hypocalcemia and renal osteodystrophy in patients with chronic renal failure undergoing dialysis. Also used in conjunction with calcium in the management and prevention of primary or corticosteroid-induced osteoporosis.

Pharmacodynamics

Cholecalciferol (vitamin D3) is a steroid hormone that has long been known for its important role in regulating body levels of calcium and phosphorus, in mineralization of bone, and for the assimilation of Vitamin A. The classical manifestations of vitamin D deficiency is rickets, which is seen in children and results in bony deformaties including bowed long bones. Deficiency in adults leads to the disease osteomalacia. Both rickets and osteomalacia reflect impaired mineralization of newly synthesized bone matrix, and usually result from a combination of inadequate exposure to sunlight and decreased dietary intake of vitamin D. Common causes of vitamin D deficiency include genetic defects in the vitamin D receptor, severe liver or kidney disease, and insufficient exposure to sunlight. Vitamin D plays an important role in maintaining calcium balance and in the regulation of parathyroid hormone (PTH). It promotes renal reabsorption of calcium, increases intestinal absorption of calcium and phosphorus, and increases calcium and phosphorus mobilization from bone to plasma.

Mechanism of action

The first step involved in the activation of vitamin D3 is a 25-hydroxylation which is catalysed by the 25-hydroxylase in the liver and then by other enzymes. The mitochondrial sterol 27-hydroxylase catalyses the first reaction in the oxidation of the side chain of sterol intermediates. The active form of vitamin D3 (calcitriol) binds to intracellular receptors that then function as transcription factors to modulate gene expression. Like the receptors for other steroid hormones and thyroid hormones, the vitamin D receptor has hormone-binding and DNA-binding domains. The vitamin D receptor forms a complex with another intracellular receptor, the retinoid-X receptor, and that heterodimer is what binds to DNA. In most cases studied, the effect is to activate transcription, but situations are also known in which vitamin D suppresses transcription. Calcitriol increases the serum calcium concentrations by: increasing GI absorption of phosphorus and calcium, increasing osteoclastic resorption, and increasing distal renal tubular reabsorption of calcium. Calcitriol appears to promote intestinal absorption of calcium through binding to the vitamin D receptor in the mucosal cytoplasm of the intestine. Subsequently, calcium is absorbed through formation of a calcium-binding protein.

TargetActionsOrganism
AVitamin D3 receptor
agonist
Human
Absorption

Readily absorbed

Volume of distribution
Not Available
Protein binding

50% to 80%

Metabolism

Within the liver, cholecalciferal is hydroxylated to calcidiol (25-hydroxycholecalciferol) by the enzyme 25-hydroxylase. Within the kidney, calcidiol serves as a substrate for 1-alpha-hydroxylase, yielding calcitriol (1,25-dihydroxycholecalciferol), the biologically active form of vitamin D3.

Route of elimination
Not Available
Half life

Several weeks

Clearance
Not Available
Toxicity

Hypercalcemia - Early symptoms of hypercalcemia, include nausea and vomiting, weakness, headache, somnolence, dry mouth, constipation, metallic taste, muscle pain and bone pain. Late symptoms and signs of hypercalcemia, include polyuria, polydipsia, anorexia, weight loss, nocturia, conjunctivitis, pancreatitis, photophobia, rhinorrhea, pruritis, hyperthermia, decreased libido, elevated BUN, albuminuria, hypercholesterolemia, elevated ALT (SGPT) and AST (SGOT), ectopic calcification, nephrocalcinosis, hypertension and cardiac arrhythmias.

Affected organisms
  • Humans and other mammals
Pathways
PathwayCategory
Atorvastatin Action PathwayDrug action
Hyper-IgD SyndromeDisease
Simvastatin Action PathwayDrug action
CHILD SyndromeDisease
Mevalonic AciduriaDisease
Rosuvastatin Action PathwayDrug action
Fluvastatin Action PathwayDrug action
DesmosterolosisDisease
Chondrodysplasia Punctata II, X-Linked Dominant (CDPX2)Disease
Steroid BiosynthesisMetabolic
Ibandronate Action PathwayDrug action
Alendronate Action PathwayDrug action
Lovastatin Action PathwayDrug action
Zoledronate Action PathwayDrug action
Smith-Lemli-Opitz Syndrome (SLOS)Disease
Cholesteryl Ester Storage DiseaseDisease
Pravastatin Action PathwayDrug action
Cerivastatin Action PathwayDrug action
Risedronate Action PathwayDrug action
Pamidronate Action PathwayDrug action
HypercholesterolemiaDisease
Lysosomal Acid Lipase Deficiency (Wolman Disease)Disease
Wolman DiseaseDisease
Steroid BiosynthesisMetabolic
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
(R)-warfarinThe metabolism of (R)-warfarin can be decreased when combined with Cholecalciferol.
(S)-WarfarinThe metabolism of (S)-Warfarin can be decreased when combined with Cholecalciferol.
1alpha-Hydroxyvitamin D5The risk or severity of adverse effects can be increased when Cholecalciferol is combined with 1alpha-Hydroxyvitamin D5.
3,5-diiodothyropropionic acidThe metabolism of 3,5-diiodothyropropionic acid can be decreased when combined with Cholecalciferol.
4-hydroxycoumarinThe metabolism of 4-hydroxycoumarin can be decreased when combined with Cholecalciferol.
4-MethoxyamphetamineThe metabolism of 4-Methoxyamphetamine can be decreased when combined with Cholecalciferol.
5-androstenedioneThe metabolism of 5-androstenedione can be decreased when combined with Cholecalciferol.
6-Deoxyerythronolide BThe metabolism of Cholecalciferol can be decreased when combined with 6-Deoxyerythronolide B.
6-O-benzylguanineThe metabolism of 6-O-benzylguanine can be decreased when combined with Cholecalciferol.
9-aminocamptothecinThe metabolism of 9-aminocamptothecin can be decreased when combined with Cholecalciferol.
Food Interactions
Not Available

References

Synthesis Reference

Jean Jolly, Primo Rizzi, Jean Taillardat, "1.alpha.,25.alpha.-Dihydroxy-cholecalciferol and methods for the production thereof." U.S. Patent US4435325, issued May, 1977.

US4435325
General References
  1. Armas LA, Hollis BW, Heaney RP: Vitamin D2 is much less effective than vitamin D3 in humans. J Clin Endocrinol Metab. 2004 Nov;89(11):5387-91. [PubMed:15531486]
External Links
Human Metabolome Database
HMDB0000876
KEGG Drug
D00188
KEGG Compound
C05443
PubChem Compound
5280795
PubChem Substance
46506365
ChemSpider
4444353
BindingDB
50030475
ChEBI
28940
ChEMBL
CHEMBL1042
Therapeutic Targets Database
DAP001273
PharmGKB
PA164748138
HET
VD3
Drugs.com
Drugs.com Drug Page
PDRhealth
PDRhealth Drug Page
Wikipedia
Cholecalciferol
ATC Codes
M05BB08 — Zoledronic acid, calcium and colecalciferol, sequentialM05BB04 — Risedronic acid, calcium and colecalciferol, sequentialA11CC05 — ColecalciferolM05BB05 — Alendronic acid, calcium and colecalciferol, sequentialM05BB03 — Alendronic acid and colecalciferolM05BX53 — Strontium ranelate and colecalciferolM05BB07 — Risedronic acid and colecalciferol
AHFS Codes
  • 88:16.00 — Vitamin D
MSDS
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Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0CompletedPreventionGingival Inflammation1
0CompletedPreventionLong Segment Barrett's Esophagus / Short Segment Barrett's Esophagus1
0CompletedTreatmentChronic Kidney Disease (CKD)1
0RecruitingBasic ScienceStage I-III Colon Cancer / Stage IV Colon Cancer With Resectable Liver Metastases / Stage, Colon Cancer1
0RecruitingPreventionDeficiency, Vitamin D1
0Unknown StatusPreventionDeficiency, Vitamin D / Periodontal Diseases1
1Active Not RecruitingTreatmentHealthy Volunteers1
1Active Not RecruitingTreatmentSarcopenia1
1CompletedNot AvailableHealthy Volunteers1
1CompletedNot AvailableHuman Immunodeficiency Virus (HIV) Infections / Infection, Human Immunodeficiency Virus I / Mycobacterium avium complex infection1
1CompletedBasic ScienceHealthy Volunteers1
1CompletedDiagnosticHealthy Volunteers1
1CompletedHealth Services ResearchDeficiency, Vitamin D1
1CompletedOtherOsteoporosis2
1CompletedPreventionCancer, Breast1
1CompletedPreventionHealthy, no Evidence of Disease / Skin Cancers1
1CompletedPreventionHuman Immunodeficiency Virus Infection(HIV)/Acquired Immunodeficiency Syndrome (AIDS)1
1CompletedTreatmentAcute and Chronic Inflammation / Autoimmune Diseases / Disorder of Pleura and Pleural Cavity / Disorder of Synovium / Felty's Syndrome / Rheumatoid Arthritis / Rheumatoid Nodules / Sjögren's Syndrome1
1CompletedTreatmentAdult Women / Estrogen Receptor Positive / Metastatic Breast Cancer (MBC)1
1CompletedTreatmentCalcium Deficiency / Deficiency, Vitamin D1
1CompletedTreatmentDeficiency, Vitamin D1
1CompletedTreatmentDeficiency, Vitamin D / Disseminated Sclerosis1
1CompletedTreatmentMalignancies / Metastases1
1CompletedTreatmentSystemic Lupus Erythematosus (SLE)1
1CompletedTreatmentType 2 Diabetes Mellitus1
1RecruitingTreatmentPneumonia1
1TerminatedBasic ScienceCrohn's Disease (CD) / Deficiency, Vitamin D1
1, 2CompletedPreventionBiomarker Change Linked to Breast Cancer1
1, 2CompletedPreventionCancer, Breast1
1, 2CompletedPreventionDeficiency, Vitamin D / Prophylaxis of preeclampsia1
1, 2CompletedPreventionPrimary Immune Deficiency Disorders (PIDD)1
1, 2CompletedTreatmentDeficiency, Vitamin D / Spinal Cord Injuries (SCI)1
1, 2CompletedTreatmentHuman Immunodeficiency Virus (HIV)1
1, 2CompletedTreatmentSickle Cell Disorders1
1, 2RecruitingTreatmentDeficiency, Vitamin D1
1, 2RecruitingTreatmentDiabetes Mellitus (DM) / Diabetes, Autoimmune / Diabetes, Diabetes Mellitus Type 1 / Hypoglycemia1
1, 2RecruitingTreatmentGestational Diabetes Mellitus (GDM)1
1, 2SuspendedTreatmentCancer, Breast / Ductal Carcinoma In-situ / Invasive Breast Carcinoma1
1, 2SuspendedTreatmentSchizoaffective Disorders / Schizophrenic Disorders1
1, 2Unknown StatusTreatmentGlioblastoma Multiforme (GBM)1
1, 2WithdrawnTreatmentDeficiency, Vitamin D1
1, 2WithdrawnTreatmentUlcerative Colitis (UC)1
2Active Not RecruitingPreventionBone Loss / Calcifications, Vascular / End Stage Renal Disease (ESRD) / Fracture Bone / Transplantation, Kidney1
2Active Not RecruitingTreatmentAcute Chest Syndrome / Asthma Bronchial / Deficiency, Vitamin D / Respiratory Tract Infections (RTI) / Sickle Cell Disorders1
2Active Not RecruitingTreatmentBone Diseases / Diabetic Nephropathies / Sub-optimal Vitamin D Status1
2Active Not RecruitingTreatmentProstate Cancer1
2CompletedBasic ScienceDeficiency, Vitamin D1
2CompletedBasic ScienceInsulin Sensitivity / Intraocular Pressure1
2CompletedBasic ScienceProstate Cancer1
2CompletedBasic ScienceType 2 Diabetes Mellitus / Vitamin D Insufficiency1
2CompletedDiagnosticHypersensitivity1
2CompletedPreventionAtherosclerosis / Systemic Lupus Erythematosus (SLE)1
2CompletedPreventionAutistic Disorder1
2CompletedPreventionCancer of the Ovary1
2CompletedPreventionCancer, Breast1
2CompletedPreventionColorectal Cancers1
2CompletedPreventionHuman Immunodeficiency Virus (HIV) Infections1
2CompletedSupportive CareArthralgia/joint pain / Muscle pains1
2CompletedTreatmentAcquired Immune Deficiency Syndrome (AIDS) / Human Immunodeficiency Virus (HIV) Infections1
2CompletedTreatmentAdenocarcinoma, Prostate / Stage I Prostate Cancer / Stage IIA Prostate Cancer / Stage IIB Prostate Cancer1
2CompletedTreatmentAllergic Rhinoconjunctivitis1
2CompletedTreatmentAtopic Dermatitis (AD) / Psoriasis1
2CompletedTreatmentAutism, Early Infantile1
2CompletedTreatmentBMI >30 kg/m21
2CompletedTreatmentCancer, Breast1
2CompletedTreatmentCholecalciferol Toxicity / Methicillin Resistant Staphylococcus Aureus (MRSA) / Resistant Staphylococcus Aureus: [Methicillin] or [Multiple] / Staphylococcus Aureus Infections / Vitamin D3 Deficiency1
2CompletedTreatmentChronic Heart Failure (CHF)1
2CompletedTreatmentChronic Kidney Disease (CKD)1
2CompletedTreatmentCongestive Heart Failure (CHF) / Deficiency, Vitamin D / Heart Failure, Unspecified / Prophylaxis of cardiomyopathy1
2CompletedTreatmentCrohn's Disease (CD)1
2CompletedTreatmentDeficiency, Vitamin D / Diabetes Mellitus (DM) / High Blood Pressure (Hypertension) / Lipid Metabolism Disorders / Obesity, Abdominal1
2CompletedTreatmentDeficiency, Vitamin D / High Blood Pressure (Hypertension)1
2CompletedTreatmentDeficiency, Vitamin D / Homocystinaemia1
2CompletedTreatmentDeficiency, Vitamin D / Human Immunodeficiency Virus (HIV) / Hyperparathyroidism / Hypovitaminosis D1
2CompletedTreatmentDepression / Diabetes Mellitus (DM) / Quality of Life1
2CompletedTreatmentDiabetes Mellitus (DM) / Executive Dysfunction1
2CompletedTreatmentEnd-Stage Renal Disease (ESRD)1
2CompletedTreatmentFalls, Accidental / Parkinson's Disease (PD)1
2CompletedTreatmentGaucher's Disease / Osteopenia1
2CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections1
2CompletedTreatmentHypovitaminosis D1
2CompletedTreatmentInfection, Human Immunodeficiency Virus I1
2CompletedTreatmentInsulin Resistance1
2CompletedTreatmentLupus / Systemic Lupus Erythematosus (SLE)1
2CompletedTreatmentNon-Alcoholic Steatohepatitis (NASH)1
2CompletedTreatmentOsteoporosis / Postmenopausal Osteoporosis (PMO)1
2CompletedTreatmentPolycystic Ovarian Syndrome / Reproductive Endocrinology1
2CompletedTreatmentProstate Cancer2
2CompletedTreatmentPulmonary Tuberculosis (TB)1
2CompletedTreatmentType 2 Diabetes Mellitus1
2Enrolling by InvitationBasic SciencePulmonary Disease, Chronic Obstructive1
2Enrolling by InvitationPreventionDiabetes, Diabetes Mellitus Type 1 / Prediabetic State1
2RecruitingOtherFracture Bone1
2RecruitingPreventionChronic Pain Due to Trauma1
2RecruitingPreventionDeficiency, Vitamin D / High Blood Pressure (Hypertension)1
2RecruitingPreventionDeficiency, Vitamin D / Peritoneal Dialysis-associated Peritonitis1
2RecruitingPreventionNeurofibromatosis Type 1 (NF1)1
2RecruitingPreventionOsteopenia / Osteoporosis1
2RecruitingTreatmentAsthma Bronchial1
2RecruitingTreatmentAtopic Dermatitis (AD)1
2RecruitingTreatmentBone Metabolism Biomarkers / Bone Mineral Density / Physical Fitness1
2RecruitingTreatmentDeficiency, Vitamin D1
2RecruitingTreatmentHuman Immunodeficiency Virus (HIV) Infections / Kidney Diseases1
2RecruitingTreatmentLeukemia Acute Myeloid Leukemia (AML)1
2RecruitingTreatmentNeoplasms, Hematologic1
2RecruitingTreatmentOptic Neuritis1
2RecruitingTreatmentTuberculosis Infection1
2TerminatedOtherDisseminated Sclerosis1
2TerminatedSupportive CareNeurologic toxicity1
2TerminatedTreatmentSystemic Lupus Erythematosus (SLE)1
2Unknown StatusPreventionSickle Cell Disorders1
2Unknown StatusTreatmentAnemia of Chronic Kidney Disease1
2Unknown StatusTreatmentBMI >30 kg/m2 / Bypass, Gastric / Gastric Resection1
2Unknown StatusTreatmentBMI >30 kg/m2 / Deficiency, Vitamin D / Insulin Resistance1
2Unknown StatusTreatmentDeficiency, Vitamin D1
2Unknown StatusTreatmentDeficiency, Vitamin D / Human Immunodeficiency Virus (HIV) Infections1
2Unknown StatusTreatmentHypovitaminosis D / Type 2 Diabetes Mellitus1
2WithdrawnBasic ScienceBMI >30 kg/m21
2WithdrawnTreatmentDeficiency, Vitamin D / Rheumatoid Arthritis1
2WithdrawnTreatmentSchizoaffective Disorders / Schizophrenic Disorders1
2, 3Active Not RecruitingTreatmentCraniocerebral Trauma / Critical Illness / Deficiency, Vitamin D / Intracranial Aneurysms / Intracranial Hemorrhages / Meningitis / Neoplasms, Brain / Seizures / Spinal Cord Injuries (SCI) / Strokes1
2, 3CompletedPreventionAdenoma benign / Colorectal Cancers / Polyps1
2, 3CompletedPreventionImpaired Glucose Tolerance (IGT)1
2, 3CompletedTreatmentCardiovascular Disease (CVD) / Chronic Kidney Disease (CKD) / The Mortality Rate1
2, 3CompletedTreatmentDeficiency, Vitamin D / Hypercalcemia / Primary Hyperparathyroidism1
2, 3CompletedTreatmentDisseminated Sclerosis1
2, 3CompletedTreatmentMale Infertility1
2, 3CompletedTreatmentType 2 Diabetes Mellitus1
2, 3Not Yet RecruitingPreventionCritical Illness / Deficiency, Vitamin D1
2, 3RecruitingTreatmentAllergies1
2, 3RecruitingTreatmentCalcifications, Vascular / Deficiency, Vitamin D / Hemodialysis Complication1
2, 3TerminatedTreatmentCancer, Breast / Musculoskeletal Disorders1
2, 3Unknown StatusTreatmentDeficiency, Vitamin D / Heart Failure, Unspecified1
3Active Not RecruitingPreventionCardiovascular Disease (CVD) / Fracture Bone / Malignancies1
3Active Not RecruitingTreatmentAcute Respiratory Distress Syndrome (ARDS) / Critical Illness / Deficiency, Vitamin D1
3Active Not RecruitingTreatmentLocally Advanced Breast Cancer and Large Operable Breast Cancer1
3Active Not RecruitingTreatmentOsteopenia1
3CompletedHealth Services ResearchDeficiency, Vitamin D1
3CompletedPreventionAcute Tracheobronchitis / Bronchiolitis Acute / Upper Respiratory Tract Infections1
3CompletedPreventionDeficiency, Vitamin D2
3CompletedPreventionDeficiency, Vitamin D / Pregnancy1
3CompletedPreventionImprove Healthy Ageing in Seniors; Prevent Disease at Older Age1
3CompletedPreventionOsteoporosis1
3CompletedTreatmentAlzheimer's Disease (AD)1
3CompletedTreatmentAnemias1
3CompletedTreatmentArterial Dysfunction / Chronic Kidney Disease (CKD)1
3CompletedTreatmentAsthma Bronchial2
3CompletedTreatmentBypass, Gastric / Parathyroid Hormone1
3CompletedTreatmentCKd Patients With Stage 3 and 41
3CompletedTreatmentCancer, Breast1
3CompletedTreatmentChronic Kidney Disease Stage 3 and 41
3CompletedTreatmentCritical Illness / Deficiency, Vitamin D1
3CompletedTreatmentDeficiency, Vitamin D4
3CompletedTreatmentDeficiency, Vitamin D / Heart Failure, Unspecified1
3CompletedTreatmentDeficiency, Vitamin D / Renal Insufficiency,Chronic1
3CompletedTreatmentDiabetes Mellitus (DM) / Insulin Resistance / Low-intensity Chronic Inflammation1
3CompletedTreatmentHepatitis C Viral Infection1
3CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Pulmonary Tuberculosis (TB)1
3CompletedTreatmentHypovitaminosis D2
3CompletedTreatmentHypovitaminosis D / Polycystic Ovaries Syndrome1
3CompletedTreatmentInfection NOS1
3CompletedTreatmentOsteoporosis2
3CompletedTreatmentPsoriasis Vulgaris (Plaque Psoriasis)1
3CompletedTreatmentPulmonary Tuberculosis (TB)1
3Not Yet RecruitingPreventionEnd Organ Damage / Multiple Organ Failure / Sepsis / Severe Sepsis1
3Not Yet RecruitingTreatmentCritical Illness / Deficiency, Vitamin D / Sarcopenia1
3Not Yet RecruitingTreatmentCrohn's Disease (CD) / Inflammatory Bowel Diseases (IBD) / Ulcerative Colitis (UC)1
3Not Yet RecruitingTreatmentDeficiency, Vitamin D1
3Not Yet RecruitingTreatmentDrug Resistant Epilepsy1
3Not Yet RecruitingTreatmentSchizophrenic Disorders1
3Not Yet RecruitingTreatmentVitamin D31
3RecruitingPreventionDisseminated Sclerosis1
3RecruitingTreatmentBacterial Infection Due to Helicobacter Pylori (H. Pylori)1
3RecruitingTreatmentCritical Illness / Deficiency, Vitamin D1
3RecruitingTreatmentCrohn's Disease (CD)1
3RecruitingTreatmentCutaneous Malignant Melanoma1
3RecruitingTreatmentDyslipidemias1
3RecruitingTreatmentHypogonadism / Pre-frail Seniors1
3RecruitingTreatmentRelapsing Remitting Multiple Sclerosis (RRMS)1
3RecruitingTreatmentUrticarias1
3TerminatedPreventionPolymorphic Light Eruption (PLE)1
3TerminatedPreventionType 2 Diabetes Mellitus1
3TerminatedTreatmentDeficiency, Vitamin D / Diabetes Mellitus (DM)1
3TerminatedTreatmentMelanoma1
3Unknown StatusNot AvailableAnemias / Low Birth Weight / Neonatal Mortality1
3Unknown StatusPreventionFalls, Accidental / Fracture Bone / Hip Fractures1
3Unknown StatusTreatmentAlzheimer's Disease (AD) / Down Syndrome (DS)1
3Unknown StatusTreatmentChronic Lymphocytic Leukaemia (CLL)1
3Unknown StatusTreatmentDeficiency, Vitamin D / Renal Osteodystrophy / Transplantation, Kidney1
3Unknown StatusTreatmentTuberculosis Infection1
3Unknown StatusTreatment[X]Statin Causing Adverse Effect in Therapeutic Use1
3WithdrawnTreatmentHuman Immunodeficiency Virus (HIV) Infections1
4Active Not RecruitingPreventionHypocalcemia1
4Active Not RecruitingTreatmentAsthma Bronchial1
4Active Not RecruitingTreatmentCalcifications, Vascular / Deficiency, Vitamin D / End Stage Renal Failure on Dialysis / Impaired Renal Function1
4Active Not RecruitingTreatmentHuman Immunodeficiency Virus (HIV) Infections1
4CompletedBasic Science25-Hydroxyvitamin D Concentration / Deficiency, Vitamin D1
4CompletedBasic ScienceDeficiency, Vitamin D2
4CompletedBasic SciencePremature Births1
4CompletedPreventionAllergies / Wheezing1
4CompletedPreventionBenign Paroxysmal Positional Vertigo (BPPV)1
4CompletedPreventionDeficiency, Vitamin D1
4CompletedPreventionDiabetes, Diabetes Mellitus Type 12
4CompletedPreventionHealthy Humans1
4CompletedPreventionImmune Tolerance1
4CompletedPreventionRecurrent Respiratory Tract Infections1
4CompletedTreatmentAnovulatory cycle / Polycystic Ovaries Syndrome1
4CompletedTreatmentBMI >30 kg/m2 / Deficiency, Vitamin D2
4CompletedTreatmentBariatric Surgery Candidate1
4CompletedTreatmentCardiorenal Syndrome / Chronic Allograft Nephropathy (CAN)1
4CompletedTreatmentDeficiency, Vitamin D2
4CompletedTreatmentDeficiency, Vitamin D / Glucose tolerance impaired / Type 2 Diabetes Mellitus1
4CompletedTreatmentDeficiency, Vitamin D / Hemodialysis Patient1
4CompletedTreatmentDeficiency, Vitamin D / Polycystic Ovaries Syndrome2
4CompletedTreatmentDiabetes Mellitus (DM)1
4CompletedTreatmentEnd Stage Kidney Disease1
4CompletedTreatmentEpilepsies1
4CompletedTreatmentHyperemesis Gravidarum / Morning Sickness / Nausea / Pregnancy / Vomiting1
4CompletedTreatmentOsteopenia / Osteoporosis1
4CompletedTreatmentPancreatitis, Chronic1
4CompletedTreatmentPneumonia1
4CompletedTreatmentPostmenopausal Osteoporosis (PMO)1
4CompletedTreatmentPregnancy1
4CompletedTreatmentSeasonal Allergic Rhinitis (SAR)1
4Not Yet RecruitingPreventionHepatocellular,Carcinoma / Viral Hepatitis B1
4Not Yet RecruitingTreatmentVitamin D Substitution1
4RecruitingPreventionEclampsia / Gestational Hypertension / HELLP Syndrome / Superimposed Preeclampsia / Toxemia1
4RecruitingPreventionFood Allergy1
4RecruitingTreatmentBone Diseases, Metabolic / Renal Insufficiency,Chronic / Vascular Stiffness1
4RecruitingTreatmentBronchiectasis1
4RecruitingTreatmentCKD Stage 3 / CKD Stage 4 / Deficiency, Vitamin D / Secondary Hyperparathyroidism Due to Renal Causes1
4RecruitingTreatmentCerebral Vascular Accident (CVA) / Heart Failure Hospitalization / Myocardial Infarction / The Mortality Rate1
4RecruitingTreatmentDeficiency, Vitamin D1
4RecruitingTreatmentDeficiency, Vitamin D / Depression / Insulin Resistance / Polycystic Ovarian Syndrome1
4RecruitingTreatmentDiabetes, Diabetes Mellitus Type 11
4TerminatedTreatmentCrohn's Disease (CD) / Deficiency, Vitamin D1
4TerminatedTreatmentHeart Failure, Unspecified1
4TerminatedTreatmentPeripheral Arterial Disease (PAD)1
4Unknown StatusDiagnosticThalassemia Major (TM)1
4Unknown StatusTreatmentAcute Lower Respiratory Tract Infection / Bronchiolitis / Pneumonia1
4Unknown StatusTreatmentBMI >30 kg/m2 / Deficiency, Vitamin D / Hyperparathyroidism, Secondary1
4Unknown StatusTreatmentBMI >30 kg/m2 / Insulin Resistance1
4Unknown StatusTreatmentDisseminated Sclerosis1
4Unknown StatusTreatmentMetabolic Syndromes1
4Unknown StatusTreatmentOsteoporosis1
4Unknown StatusTreatmentPersistent Asthma1
4WithdrawnTreatmentCrohn's Disease (CD)1
4WithdrawnTreatmentNephritis / Proteinuria / Systemic Lupus Erythematosus (SLE)1
Not AvailableActive Not RecruitingPreventionHypovitaminosis D1
Not AvailableActive Not RecruitingSupportive CarePrimary Hyperparathyroidism1
Not AvailableActive Not RecruitingTreatmentAsthma Bronchial / Deficiency, Vitamin D1
Not AvailableActive Not RecruitingTreatmentCardiovascular Disease (CVD) / Deficiency, Vitamin D / High Blood Pressure (Hypertension) / Insulin Resistance / Type 2 Diabetes Mellitus1
Not AvailableCompletedNot AvailableDeficiency, Vitamin D1
Not AvailableCompletedNot AvailableDiabetes, Diabetes Mellitus Type 11
Not AvailableCompletedNot AvailableHMG COA Reductase Inhibitor Adverse Reaction1
Not AvailableCompletedNot AvailableHuman Immunodeficiency Virus (HIV) Infections1
Not AvailableCompletedNot AvailableOsteoporosis1
Not AvailableCompletedPreventionBlood Platelet Disorders / Deficiency, Vitamin D1
Not AvailableCompletedPreventionCancer, Breast1
Not AvailableCompletedPreventionDeficiency, Vitamin D1
Not AvailableCompletedPreventionMalignant Melanoma of Skin1
Not AvailableCompletedPreventionNeural Tube Defects (NTDs)1
Not AvailableCompletedPreventionOsteoporosis1
Not AvailableCompletedPreventionSarcopenia1
Not AvailableCompletedSupportive CareBurn Injuries / Vitamin D1
Not AvailableCompletedSupportive CareDiabetic Neuropathies1
Not AvailableCompletedSupportive CarePulmonary Tuberculosis (TB)1
Not AvailableCompletedTreatmentAngioedema / Hives / Swelling / Urticarias1
Not AvailableCompletedTreatmentAsthma Bronchial / Deficiency, Vitamin D / Disease Exacerbation1
Not AvailableCompletedTreatmentAtherosclerosis / Leukocyte Activation Disorder / Oxidative Stress1
Not AvailableCompletedTreatmentBipolar Disorder (BD) / Depression, Bipolar1
Not AvailableCompletedTreatmentChronic Kidney Disease (CKD) / Deficiency, Vitamin D1
Not AvailableCompletedTreatmentChronic Kidney Disease (CKD) / Deficiency, Vitamin D / Insulin Resistance1
Not AvailableCompletedTreatmentChronic Kidney Disease (CKD) / End-Stage Renal Disease (ESRD)1
Not AvailableCompletedTreatmentClozapine Resistant Schizophrenia1
Not AvailableCompletedTreatmentCystic Fibrosis (CF)1
Not AvailableCompletedTreatmentCystic Fibrosis (CF) / Osteoporosis1
Not AvailableCompletedTreatmentDeficiency of Vitamin D3 / Gingival and Periodontal Disease / Pregnancy1
Not AvailableCompletedTreatmentDeficiency, Vitamin D4
Not AvailableCompletedTreatmentDeficiency, Vitamin D / End-Stage Renal Disease (ESRD)1
Not AvailableCompletedTreatmentDeficiency, Vitamin D / High Blood Pressure (Hypertension) / Pre-Hypertension1
Not AvailableCompletedTreatmentDeficiency, Vitamin D / Renal Failure Chronic Requiring Hemodialysis1
Not AvailableCompletedTreatmentEnd-Stage Renal Disease (ESRD)2
Not AvailableCompletedTreatmentEndometriosis1
Not AvailableCompletedTreatmentHeart Failure, Unspecified1
Not AvailableCompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections1
Not AvailableCompletedTreatmentHyperparathyroidism, Secondary / Renal Insufficiency,Chronic1
Not AvailableCompletedTreatmentHypovitaminosis D1
Not AvailableCompletedTreatmentIntestinal Malabsorption / Pancreatitis, Chronic1
Not AvailableCompletedTreatmentNeoplasms, Brain1
Not AvailableCompletedTreatmentPolycystic Ovaries Syndrome1
Not AvailableCompletedTreatmentRenal Osteodystrophy / Secondary Hyperparathyroidism in Chronic Kidney Disease Stage 3 and 41
Not AvailableCompletedTreatmentSystemic Lupus Erythematosus (SLE)1
Not AvailableCompletedTreatmentType 2 Diabetes Mellitus1
Not AvailableNot Yet RecruitingPreventionTransient Hypercalciuria1
Not AvailableNot Yet RecruitingSupportive CareHematopoietic Stem Cell Transplant (HSCT)1
Not AvailableNot Yet RecruitingTreatmentPeripheral Arterial Disease (PAD)1
Not AvailableNot Yet RecruitingTreatmentSchizophrenic Disorders1
Not AvailableRecruitingTreatmentBMI >30 kg/m21
Not AvailableRecruitingTreatmentCancer of the Ovary1
Not AvailableRecruitingTreatmentCancer, Breast1
Not AvailableRecruitingTreatmentDeficiency, Vitamin D / Glucose tolerance impaired / Insulin Resistance / Oxidative Stress1
Not AvailableRecruitingTreatmentNeoplasms, Brain1
Not AvailableRecruitingTreatmentProphylaxis of Contrast-induced nephropathy1
Not AvailableTerminatedNot AvailableUrolithiasis1
Not AvailableTerminatedBasic ScienceCancer, Breast1
Not AvailableTerminatedTreatmentDeficiency, Vitamin D1
Not AvailableTerminatedTreatmentHMG-CoA Reductase Inhibitors-related Myalgias1
Not AvailableUnknown StatusTreatmentChronic Musculoskeletal Pain / Vitamin D Supplementation1
Not AvailableUnknown StatusTreatmentDeficiency, Vitamin D / Hepatocellular,Carcinoma1
Not AvailableUnknown StatusTreatmentDyslipidemia (Fredrickson Type Ⅱa)1
Not AvailableWithdrawnTreatmentChronic Rhinosinusitis1
Not AvailableWithdrawnTreatmentHMG COA Reductase Inhibitor Adverse Reaction1
Not AvailableWithdrawnTreatmentInflammatory Bowel Diseases (IBD) / Ulcerative Colitis (UC)1
Not AvailableWithdrawnTreatmentTuberculosis Infection1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
  • Chain Drug
  • CVS Pharmacy
  • Freeda Vitamins
  • Major Pharmaceuticals
  • Mason Distributors
  • Merck & Co.
  • MSD Frosst Iberica SA
  • Pharmavite
  • Physicians Total Care Inc.
  • Professional Co.
  • Spectrum Pharmaceuticals
Dosage forms
FormRouteStrength
OintmentTopical
Granule, effervescent; kit; tabletOral
CreamTopical
Tablet, chewableOral
Granule, effervescentOral
CapsuleOral
Solution / dropsOral400 unit
TabletOral10000 unit
PowderOral
WaferOral100 unit
Tablet, coatedOral
Solution / dropsOral
CapsuleOral2000 unit
CapsuleOral25000 unit
LiquidOral
SolutionOral
Tablet, orally disintegratingOral
Injection, solutionIntravenous
CapsuleOral10000 unit
CapsuleOral5000 unit
CapsuleOral50000 unit
Tablet, film coatedOral
Capsule, gelatin coatedOral
PillOral
KitOral
WaferOral
Tablet, effervescentOral
Capsule, liquid filledOral
TabletOral
TabletOral1000 unit
TabletOral400 unit
CapsuleOral100000 unit
Kit
Prices
Unit descriptionCostUnit
Cholecalciferol crystals104.3USD g
Vitamin d3 2400 unit/ml liquid0.8USD ml
Vitamin d3 2000 unit spray0.44USD ml
Vitamin d3 3000 unit tablet0.11USD tablet
Vitamin d-3 2000 unit tablet0.07USD tablet
CVS Pharmacy vitamin d 1000 unit tablet0.04USD tablet
Delta d3 400 unit tablet0.04USD each
Vitamin d 1000 unit tablet0.03USD tablet
Pv vitamin d 2000 unit tablet0.02USD tablet
Pv vitamin d 5000 unit tablet0.02USD tablet
Vitamin d 400 unit tablet0.02USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US5994329Yes1999-11-302019-01-17Us

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)84.5 °CPhysProp
water solubilityInsolubleNot Available
logP7.5Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00038 mg/mLALOGPS
logP7.98ALOGPS
logP7.13ChemAxon
logS-6ALOGPS
pKa (Strongest Acidic)18.38ChemAxon
pKa (Strongest Basic)-1.3ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count1ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area20.23 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity123.22 m3·mol-1ChemAxon
Polarizability49.6 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+1.0
Blood Brain Barrier+0.959
Caco-2 permeable+0.8342
P-glycoprotein substrateSubstrate0.6706
P-glycoprotein inhibitor IInhibitor0.7603
P-glycoprotein inhibitor IINon-inhibitor0.5346
Renal organic cation transporterNon-inhibitor0.7818
CYP450 2C9 substrateNon-substrate0.8384
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateSubstrate0.7302
CYP450 1A2 substrateNon-inhibitor0.9256
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorNon-inhibitor0.9551
CYP450 2C19 inhibitorNon-inhibitor0.9026
CYP450 3A4 inhibitorNon-inhibitor0.7881
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.7093
Ames testNon AMES toxic0.9132
CarcinogenicityNon-carcinogens0.921
BiodegradationNot ready biodegradable0.9878
Rat acute toxicity3.9310 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.773
hERG inhibition (predictor II)Non-inhibitor0.7589
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Download (11.1 KB)
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as vitamin d and derivatives. These are compounds containing a secosteroid backbone, usually secoergostane or secocholestane.
Kingdom
Organic compounds
Super Class
Lipids and lipid-like molecules
Class
Steroids and steroid derivatives
Sub Class
Vitamin D and derivatives
Direct Parent
Vitamin D and derivatives
Alternative Parents
Triterpenoids / Secondary alcohols / Cyclic alcohols and derivatives / Hydrocarbon derivatives
Substituents
Triterpenoid / Cyclic alcohol / Secondary alcohol / Organic oxygen compound / Hydrocarbon derivative / Organooxygen compound / Alcohol / Aliphatic homopolycyclic compound
Molecular Framework
Aliphatic homopolycyclic compounds
External Descriptors
secondary alcohol, steroid hormone, seco-cholestane, hydroxy seco-steroid, D3 vitamins (CHEBI:28940) / Vitamin D3 and derivatives, Fat-soluble vitamins (C05443) / Vitamin D3 and derivatives (LMST03020000)

Targets

Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Agonist
General Function
Zinc ion binding
Specific Function
Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Recruited to promoters via its interaction with BAZ1B...
Gene Name
VDR
Uniprot ID
P11473
Uniprot Name
Vitamin D3 receptor
Molecular Weight
48288.64 Da
References
  1. Reinhart GA: Vitamin D analogs: novel therapeutic agents for cardiovascular disease? Curr Opin Investig Drugs. 2004 Sep;5(9):947-51. [PubMed:15503649]
  2. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352]
  3. Fujishima T, Tsuji G, Tanaka C, Harayama H: Novel vitamin D receptor ligands having a carboxyl group as an anchor to arginine 274 in the ligand-binding domain. J Steroid Biochem Mol Biol. 2010 Jul;121(1-2):60-2. doi: 10.1016/j.jsbmb.2010.04.020. Epub 2010 May 6. [PubMed:20435140]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3).
Gene Name
CYP2R1
Uniprot ID
Q6VVX0
Uniprot Name
Vitamin D 25-hydroxylase
Molecular Weight
57358.82 Da
References
  1. Flanagan JN, Young MV, Persons KS, Wang L, Mathieu JS, Whitlatch LW, Holick MF, Chen TC: Vitamin D metabolism in human prostate cells: implications for prostate cancer chemoprevention by vitamin D. Anticancer Res. 2006 Jul-Aug;26(4A):2567-72. [PubMed:16886665]
  2. Segura-Aguilar J: Peroxidase activity of liver microsomal vitamin D 25-hydroxylase and cytochrome P450 1A2 catalyzes 25-hydroxylation of vitamin D3 and oxidation of dopamine to aminochrome. Biochem Mol Med. 1996 Jun;58(1):122-9. [PubMed:8809353]
  3. Schuster I: Cytochromes P450 are essential players in the vitamin D signaling system. Biochim Biophys Acta. 2011 Jan;1814(1):186-99. doi: 10.1016/j.bbapap.2010.06.022. Epub 2010 Jul 7. [PubMed:20619365]
  4. Ohyama Y, Yamasaki T: Eight cytochrome P450s catalyze vitamin D metabolism. Front Biosci. 2004 Sep 1;9:3007-18. [PubMed:15353333]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Catalyzes the first step in the oxidation of the side chain of sterol intermediates; the 27-hydroxylation of 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol. Has also a vitamin D3-25-hydroxylase a...
Gene Name
CYP27A1
Uniprot ID
Q02318
Uniprot Name
Sterol 26-hydroxylase, mitochondrial
Molecular Weight
60234.28 Da
References
  1. Lehmann B, Tiebel O, Meurer M: Expression of vitamin D3 25-hydroxylase (CYP27) mRNA after induction by vitamin D3 or UVB radiation in keratinocytes of human skin equivalents--a preliminary study. Arch Dermatol Res. 1999 Sep;291(9):507-10. [PubMed:10541881]
  2. Sawada N, Sakaki T, Yoneda S, Kusudo T, Shinkyo R, Ohta M, Inouye K: Conversion of vitamin D3 to 1alpha,25-dihydroxyvitamin D3 by Streptomyces griseolus cytochrome P450SU-1. Biochem Biophys Res Commun. 2004 Jul 16;320(1):156-64. [PubMed:15207715]
  3. Uchida E, Kagawa N, Sakaki T, Urushino N, Sawada N, Kamakura M, Ohta M, Kato S, Inouye K: Purification and characterization of mouse CYP27B1 overproduced by an Escherichia coli system coexpressing molecular chaperonins GroEL/ES. Biochem Biophys Res Commun. 2004 Oct 15;323(2):505-11. [PubMed:15369780]
  4. Sakaki T, Kagawa N, Yamamoto K, Inouye K: Metabolism of vitamin D3 by cytochromes P450. Front Biosci. 2005 Jan 1;10:119-34. Print 2005 Jan 1. [PubMed:15574355]
  5. Tokar EJ, Webber MM: Cholecalciferol (vitamin D3) inhibits growth and invasion by up-regulating nuclear receptors and 25-hydroxylase (CYP27A1) in human prostate cancer cells. Clin Exp Metastasis. 2005;22(3):275-84. [PubMed:16158255]
  6. Schuster I: Cytochromes P450 are essential players in the vitamin D signaling system. Biochim Biophys Acta. 2011 Jan;1814(1):186-99. doi: 10.1016/j.bbapap.2010.06.022. Epub 2010 Jul 7. [PubMed:20619365]
  7. Ohyama Y, Yamasaki T: Eight cytochrome P450s catalyze vitamin D metabolism. Front Biosci. 2004 Sep 1;9:3007-18. [PubMed:15353333]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Steroid hydroxylase activity
Specific Function
This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation to all four regioisomeric cis-epoxyeicosatrienoic acids. One of the predominant enzymes responsible f...
Gene Name
CYP2J2
Uniprot ID
P51589
Uniprot Name
Cytochrome P450 2J2
Molecular Weight
57610.165 Da
References
  1. Aiba I, Yamasaki T, Shinki T, Izumi S, Yamamoto K, Yamada S, Terato H, Ide H, Ohyama Y: Characterization of rat and human CYP2J enzymes as Vitamin D 25-hydroxylases. Steroids. 2006 Oct;71(10):849-56. Epub 2006 Jul 13. [PubMed:16842832]
  2. Schuster I: Cytochromes P450 are essential players in the vitamin D signaling system. Biochim Biophys Acta. 2011 Jan;1814(1):186-99. doi: 10.1016/j.bbapap.2010.06.022. Epub 2010 Jul 7. [PubMed:20619365]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Schuster I: Cytochromes P450 are essential players in the vitamin D signaling system. Biochim Biophys Acta. 2011 Jan;1814(1):186-99. doi: 10.1016/j.bbapap.2010.06.022. Epub 2010 Jul 7. [PubMed:20619365]
  2. Ohyama Y, Yamasaki T: Eight cytochrome P450s catalyze vitamin D metabolism. Front Biosci. 2004 Sep 1;9:3007-18. [PubMed:15353333]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, nad(p)h as one donor, and incorporation of one atom of oxygen
Specific Function
Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.
Gene Name
CYP11A1
Uniprot ID
P05108
Uniprot Name
Cholesterol side-chain cleavage enzyme, mitochondrial
Molecular Weight
60101.87 Da
References
  1. Tuckey RC, Janjetovic Z, Li W, Nguyen MN, Zmijewski MA, Zjawiony J, Slominski A: Metabolism of 1alpha-hydroxyvitamin D3 by cytochrome P450scc to biologically active 1alpha,20-dihydroxyvitamin D3. J Steroid Biochem Mol Biol. 2008 Dec;112(4-5):213-9. doi: 10.1016/j.jsbmb.2008.10.005. Epub 2008 Oct 21. [PubMed:19000766]
  2. Tuckey RC, Nguyen MN, Slominski A: Kinetics of vitamin D3 metabolism by cytochrome P450scc (CYP11A1) in phospholipid vesicles and cyclodextrin. Int J Biochem Cell Biol. 2008;40(11):2619-26. doi: 10.1016/j.biocel.2008.05.006. Epub 2008 May 20. [PubMed:18573681]
  3. Guryev O, Carvalho RA, Usanov S, Gilep A, Estabrook RW: A pathway for the metabolism of vitamin D3: unique hydroxylated metabolites formed during catalysis with cytochrome P450scc (CYP11A1). Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14754-9. Epub 2003 Dec 1. [PubMed:14657394]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Vitamin d 24-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP1A1
Uniprot ID
P04798
Uniprot Name
Cytochrome P450 1A1
Molecular Weight
58164.815 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2B6
Uniprot ID
P20813
Uniprot Name
Cytochrome P450 2B6
Molecular Weight
56277.81 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
  2. Rendic S: Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. [PubMed:11996015]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2C8
Uniprot ID
P10632
Uniprot Name
Cytochrome P450 2C8
Molecular Weight
55824.275 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
  2. Rendic S: Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. [PubMed:11996015]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Steroid hydroxylase activity
Specific Function
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic...
Gene Name
CYP2D6
Uniprot ID
P10635
Uniprot Name
Cytochrome P450 2D6
Molecular Weight
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]

Carriers

Kind
Protein
Organism
Human
Pharmacological action
No
General Function
Vitamin transporter activity
Specific Function
Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.
Gene Name
GC
Uniprot ID
P02774
Uniprot Name
Vitamin D-binding protein
Molecular Weight
52963.025 Da
References
  1. Nykjaer A, Dragun D, Walther D, Vorum H, Jacobsen C, Herz J, Melsen F, Christensen EI, Willnow TE: An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3. Cell. 1999 Feb 19;96(4):507-15. [PubMed:10052453]
  2. Verboven C, Rabijns A, De Maeyer M, Van Baelen H, Bouillon R, De Ranter C: A structural basis for the unique binding features of the human vitamin D-binding protein. Nat Struct Biol. 2002 Feb;9(2):131-6. [PubMed:11799400]
  3. Houghton LA, Vieth R: The case against ergocalciferol (vitamin D2) as a vitamin supplement. Am J Clin Nutr. 2006 Oct;84(4):694-7. [PubMed:17023693]
  4. Yamamoto N, Naraparaju VR: Vitamin D3-binding protein as a precursor for macrophage activating factor in the inflammation-primed macrophage activation cascade in rats. Cell Immunol. 1996 Jun 15;170(2):161-7. [PubMed:8660814]
  5. Yamamoto N, Naraparaju VR: Role of vitamin D3-binding protein in activation of mouse macrophages. J Immunol. 1996 Aug 15;157(4):1744-9. [PubMed:8759764]

Drug created on June 13, 2005 07:24 / Updated on December 14, 2018 05:18