Identification

Name
Cholecalciferol
Accession Number
DB00169  (NUTR00008, APRD00506)
Type
Small Molecule
Groups
Approved, Nutraceutical
Description

Derivative of 7-dehydroxycholesterol formed by ultraviolet rays breaking of the C9-C10 bond. It differs from ergocalciferol in having a single bond between C22 and C23 and lacking a methyl group at C24.

Structure
Thumb
Synonyms
  • (+)-vitamin D3
  • (1S,3Z)-3-[(2e)-2-[(1R,3AR,7as)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexan-1-ol
  • (3β,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol
  • (5Z,7E)-(3S)-9,10-secocholesta-5,7,10(19)-trien-3-ol
  • Activated 7-dehydrocholesterol
  • Calciol
  • CC
  • Colecalciferol
  • colecalciferolum
  • Oleovitamin D3
  • Vitamin D-3
  • Vitamin D3
External IDs
NSC-375571
Product Images
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Cataplex D Tab 400unitTablet400 unitOralStandard Process Inc.Not applicableNot applicableCanada
D-tabs 10000unitTablet10000 unitOralLaboratoire Riva Inc1992-12-31Not applicableCanada
Euro D 10 000Capsule10000 unitOralSandoz Canada Incorporated2005-04-06Not applicableCanada
Euro D 10 000Capsule10000 unitOralEuro Pharm International Canada Inc2017-08-16Not applicableCanada
Formula 3200 Waf 100unitWafer100 unitOralStandard Process Inc.Not applicableNot applicableCanada
Jamp-vitamin DCapsule50000 unitOralJamp Pharma Corporation2016-06-23Not applicableCanada
Jamp-vitamin DTablet10000 unitOralJamp Pharma Corporation2012-05-02Not applicableCanada
Jamp-vitamin DCapsule10000 unitOralJamp Pharma Corporation2015-11-20Not applicableCanada
Jamp-vitamin DCapsule25000 unitOralJamp Pharma CorporationNot applicableNot applicableCanada
Jamp-vitamin DCapsule2000 unitOralJamp Pharma CorporationNot applicableNot applicableCanada
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
D Vi Sol Infants Drops 400unit/0.6mlSolution / drops400 unitOralMead Johnson Nutritionals1985-12-311998-09-28Canada
Vitamin D 1000iuTablet1000 unitOralWn Pharmaceuticals Ltd.1999-07-082007-08-07Canada
Vitamin D 400 IuTablet400 unitOralWn Pharmaceuticals Ltd.2002-03-132007-08-07Canada
Vitamin D 400 Iu TabletsTablet400 unitOralSwiss Herbal Remedies Ltd.1996-12-112009-08-04Canada
Vitamin D-dry 400 I.U.Tablet400 unitOralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
International/Other Brands
Delta-D / Micro-D / Optimal-D (RV Nutritional, LLC) / Vigantol
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
A + D OintmentCholecalciferol (500 unit) + Vitamin A palmitate (2000 unit)OintmentTopicalNational Care Products Ltd.1993-12-312002-10-10Canada
A.R.T.H. Away FormulaCholecalciferol (45 unit) + Calcium (24 mg) + Copper (0.232 mg) + Folic Acid (0.025 mg) + Manganese (0.58 mg) + Pyridoxine hydrochloride (0.5 mg) + Selenium (1.54 mcg) + Zinc (0.63 mg)CapsuleOralAbundance Marketing Ltd.1999-02-012006-06-16Canada
Acti-cal/mag 2:1 + Zinc and D CapletCholecalciferol (100 unit) + Calcium (350.0 mg) + Magnesium (175.0 mg) + Zinc (6.0 mg)TabletOralActi Form Ltd.1991-12-312005-03-21Canada
Actical Plus Calcium-magnesium-vitamin D3-silicon ChewableCholecalciferol (100 unit) + Calcium (200 mg) + Magnesium (100 mg) + Silicon (2 mg)TabletOralUsana Health Sciences, Inc.1999-09-302004-07-27Canada
Active Calcium Plus Magnesium, Vitamin D and SiliconCholecalciferol (100 unit) + Calcium (200 mg) + Magnesium (100 mg) + Silicon (2.25 mg)TabletOralUsana Health Sciences, Inc.2002-07-082007-07-18Canada
Active FECholecalciferol (400 [iU]/1) + Beta carotene (2100 [iU]/1) + Cupric oxide (1 mg/1) + Cyanocobalamin (30 ug/1) + Folic Acid (1250 ug/1) + Iron (75 mg/1) + Magnesium oxide (30 mg/1) + Nicotinamide (20 mg/1) + Pyridoxine hydrochloride (20 mg/1) + Riboflavin (4 mg/1) + Thiamine Hydrochloride (4 mg/1) + Vitamin C (160 mg/1) + Vitamin E (40 [iU]/1) + Zinc oxide (20 mg/1)TabletOralGm Pharmaceuticals2013-11-11Not applicableUs
Actonel Sachet KitCholecalciferol (880 unit) + Calcium (1000 mg) + Risedronate sodium (35 mg)Granule, effervescent; Kit; TabletOralWarner ChilcottNot applicableNot applicableCanada
AdrovanceCholecalciferol (5600 IU) + Alendronate sodium (70 mg)TabletOralMerck Sharp & Dohme Limited2007-01-04Not applicableEu
AdrovanceCholecalciferol (2800 IU) + Alendronate sodium (70 mg)TabletOralMerck Sharp & Dohme Limited2007-01-04Not applicableEu
AdrovanceCholecalciferol (5600 IU) + Alendronate sodium (70 mg)TabletOralMerck Sharp & Dohme Limited2007-01-04Not applicableEu
Categories
UNII
1C6V77QF41
CAS number
67-97-0
Weight
Average: 384.6377
Monoisotopic: 384.33921603
Chemical Formula
C27H44O
InChI Key
QYSXJUFSXHHAJI-YRZJJWOYSA-N
InChI
InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
IUPAC Name
(1S,3Z)-3-{2-[(1R,3aS,4E,7aR)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-octahydro-1H-inden-4-ylidene]ethylidene}-4-methylidenecyclohexan-1-ol
SMILES
CC(C)CCC[[email protected]@H](C)[[email protected]@]1([H])CC[[email protected]@]2([H])\C(CCC[[email protected]]12C)=C\C=C1\C[[email protected]@H](O)CCC1=C

Pharmacology

Indication

For the treatment of vitamin D deficiency or insufficiency, refractory rickets (vitamin D resistant rickets), familial hypophosphatemia and hypoparathyroidism, and in the management of hypocalcemia and renal osteodystrophy in patients with chronic renal failure undergoing dialysis. Also used in conjunction with calcium in the management and prevention of primary or corticosteroid-induced osteoporosis.

Structured Indications
Not Available
Pharmacodynamics

Cholecalciferol (vitamin D3) is a steroid hormone that has long been known for its important role in regulating body levels of calcium and phosphorus, in mineralization of bone, and for the assimilation of Vitamin A. The classical manifestations of vitamin D deficiency is rickets, which is seen in children and results in bony deformaties including bowed long bones. Deficiency in adults leads to the disease osteomalacia. Both rickets and osteomalacia reflect impaired mineralization of newly synthesized bone matrix, and usually result from a combination of inadequate exposure to sunlight and decreased dietary intake of vitamin D. Common causes of vitamin D deficiency include genetic defects in the vitamin D receptor, severe liver or kidney disease, and insufficient exposure to sunlight. Vitamin D plays an important role in maintaining calcium balance and in the regulation of parathyroid hormone (PTH). It promotes renal reabsorption of calcium, increases intestinal absorption of calcium and phosphorus, and increases calcium and phosphorus mobilization from bone to plasma.

Mechanism of action

The first step involved in the activation of vitamin D3 is a 25-hydroxylation which is catalysed by the 25-hydroxylase in the liver and then by other enzymes. The mitochondrial sterol 27-hydroxylase catalyses the first reaction in the oxidation of the side chain of sterol intermediates. The active form of vitamin D3 (calcitriol) binds to intracellular receptors that then function as transcription factors to modulate gene expression. Like the receptors for other steroid hormones and thyroid hormones, the vitamin D receptor has hormone-binding and DNA-binding domains. The vitamin D receptor forms a complex with another intracellular receptor, the retinoid-X receptor, and that heterodimer is what binds to DNA. In most cases studied, the effect is to activate transcription, but situations are also known in which vitamin D suppresses transcription. Calcitriol increases the serum calcium concentrations by: increasing GI absorption of phosphorus and calcium, increasing osteoclastic resorption, and increasing distal renal tubular reabsorption of calcium. Calcitriol appears to promote intestinal absorption of calcium through binding to the vitamin D receptor in the mucosal cytoplasm of the intestine. Subsequently, calcium is absorbed through formation of a calcium-binding protein.

TargetActionsOrganism
AVitamin D3 receptor
agonist
Human
Absorption

Readily absorbed

Volume of distribution
Not Available
Protein binding

50% to 80%

Metabolism

Within the liver, cholecalciferal is hydroxylated to calcidiol (25-hydroxycholecalciferol) by the enzyme 25-hydroxylase. Within the kidney, calcidiol serves as a substrate for 1-alpha-hydroxylase, yielding calcitriol (1,25-dihydroxycholecalciferol), the biologically active form of vitamin D3.

Route of elimination
Not Available
Half life

Several weeks

Clearance
Not Available
Toxicity

Hypercalcemia - Early symptoms of hypercalcemia, include nausea and vomiting, weakness, headache, somnolence, dry mouth, constipation, metallic taste, muscle pain and bone pain. Late symptoms and signs of hypercalcemia, include polyuria, polydipsia, anorexia, weight loss, nocturia, conjunctivitis, pancreatitis, photophobia, rhinorrhea, pruritis, hyperthermia, decreased libido, elevated BUN, albuminuria, hypercholesterolemia, elevated ALT (SGPT) and AST (SGOT), ectopic calcification, nephrocalcinosis, hypertension and cardiac arrhythmias.

Affected organisms
  • Humans and other mammals
Pathways
PathwayCategory
Alendronate Action PathwayDrug action
Zoledronate Action PathwayDrug action
Wolman diseaseDisease
Pravastatin Action PathwayDrug action
Risedronate Action PathwayDrug action
HypercholesterolemiaDisease
Rosuvastatin Action PathwayDrug action
Fluvastatin Action PathwayDrug action
CHILD SyndromeDisease
Hyper-IgD syndromeDisease
Cerivastatin Action PathwayDrug action
Pamidronate Action PathwayDrug action
Atorvastatin Action PathwayDrug action
Cholesteryl ester storage diseaseDisease
Mevalonic aciduriaDisease
Steroid BiosynthesisMetabolic
Ibandronate Action PathwayDrug action
Simvastatin Action PathwayDrug action
Lovastatin Action PathwayDrug action
Lysosomal Acid Lipase Deficiency (Wolman Disease)Disease
DesmosterolosisDisease
Chondrodysplasia Punctata II, X Linked Dominant (CDPX2)Disease
Smith-Lemli-Opitz Syndrome (SLOS)Disease
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
4-MethoxyamphetamineThe metabolism of 4-Methoxyamphetamine can be decreased when combined with Cholecalciferol.Experimental, Illicit
AceclofenacThe metabolism of Aceclofenac can be decreased when combined with Cholecalciferol.Approved
AcenocoumarolThe metabolism of Acenocoumarol can be decreased when combined with Cholecalciferol.Approved
AcetaminophenThe metabolism of Acetaminophen can be decreased when combined with Cholecalciferol.Approved
AcetylcholineThe metabolism of Acetylcholine can be decreased when combined with Cholecalciferol.Approved
Acetylsalicylic acidThe metabolism of Acetylsalicylic acid can be decreased when combined with Cholecalciferol.Approved, Vet Approved
AdinazolamThe metabolism of Adinazolam can be decreased when combined with Cholecalciferol.Approved
AjmalineThe metabolism of Ajmaline can be decreased when combined with Cholecalciferol.Approved
AlmotriptanThe metabolism of Almotriptan can be decreased when combined with Cholecalciferol.Approved, Investigational
AlogliptinThe metabolism of Alogliptin can be decreased when combined with Cholecalciferol.Approved
AlosetronThe metabolism of Alosetron can be decreased when combined with Cholecalciferol.Approved, Withdrawn
AlprazolamThe metabolism of Alprazolam can be decreased when combined with Cholecalciferol.Approved, Illicit, Investigational
AlprenololThe metabolism of Alprenolol can be decreased when combined with Cholecalciferol.Approved, Withdrawn
AmbrisentanThe metabolism of Ambrisentan can be decreased when combined with Cholecalciferol.Approved, Investigational
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Cholecalciferol.Approved, Withdrawn
AmiodaroneThe metabolism of Cholecalciferol can be decreased when combined with Amiodarone.Approved, Investigational
AmitriptylineThe metabolism of Amitriptyline can be decreased when combined with Cholecalciferol.Approved
AmodiaquineThe serum concentration of Amodiaquine can be increased when it is combined with Cholecalciferol.Approved
AmoxapineThe metabolism of Amoxapine can be decreased when combined with Cholecalciferol.Approved
AmoxicillinThe metabolism of Amoxicillin can be decreased when combined with Cholecalciferol.Approved, Vet Approved
AmphetamineThe metabolism of Amphetamine can be decreased when combined with Cholecalciferol.Approved, Illicit
AmprenavirThe metabolism of Amprenavir can be decreased when combined with Cholecalciferol.Approved
AmsacrineThe metabolism of Amsacrine can be decreased when combined with Cholecalciferol.Approved
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Cholecalciferol.Approved
ApixabanThe metabolism of Apixaban can be decreased when combined with Cholecalciferol.Approved
AprepitantThe serum concentration of Cholecalciferol can be increased when it is combined with Aprepitant.Approved, Investigational
AprindineThe metabolism of Aprindine can be decreased when combined with Cholecalciferol.Approved
Arachidonic AcidThe metabolism of Arachidonic Acid can be decreased when combined with Cholecalciferol.Experimental
ArformoterolThe metabolism of Arformoterol can be decreased when combined with Cholecalciferol.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Cholecalciferol.Approved, Investigational
ArtemetherThe metabolism of Artemether can be decreased when combined with Cholecalciferol.Approved
AstemizoleThe metabolism of Astemizole can be decreased when combined with Cholecalciferol.Approved, Withdrawn
AtazanavirThe metabolism of Cholecalciferol can be decreased when combined with Atazanavir.Approved, Investigational
AtomoxetineThe metabolism of Cholecalciferol can be decreased when combined with Atomoxetine.Approved
AxitinibThe metabolism of Axitinib can be decreased when combined with Cholecalciferol.Approved, Investigational
AzelastineThe metabolism of Azelastine can be decreased when combined with Cholecalciferol.Approved
BenzatropineThe metabolism of Benzatropine can be decreased when combined with Cholecalciferol.Approved
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Cholecalciferol.Approved
BepridilThe metabolism of Bepridil can be decreased when combined with Cholecalciferol.Approved, Withdrawn
BetaxololThe metabolism of Betaxolol can be decreased when combined with Cholecalciferol.Approved
BexaroteneThe metabolism of Bexarotene can be decreased when combined with Cholecalciferol.Approved, Investigational
BisoprololThe metabolism of Bisoprolol can be decreased when combined with Cholecalciferol.Approved
BoceprevirThe metabolism of Cholecalciferol can be decreased when combined with Boceprevir.Withdrawn
BortezomibThe metabolism of Cholecalciferol can be decreased when combined with Bortezomib.Approved, Investigational
BosentanThe serum concentration of Bosentan can be increased when it is combined with Cholecalciferol.Approved, Investigational
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Cholecalciferol.Approved
BrivaracetamThe metabolism of Brivaracetam can be decreased when combined with Cholecalciferol.Approved, Investigational
BromazepamThe metabolism of Bromazepam can be decreased when combined with Cholecalciferol.Approved, Illicit
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Cholecalciferol.Approved
BufuralolThe metabolism of Bufuralol can be decreased when combined with Cholecalciferol.Experimental, Investigational
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Cholecalciferol.Approved, Investigational
BuprenorphineThe metabolism of Buprenorphine can be decreased when combined with Cholecalciferol.Approved, Illicit, Investigational, Vet Approved
BupropionThe metabolism of Bupropion can be decreased when combined with Cholecalciferol.Approved
BuspironeThe metabolism of Buspirone can be decreased when combined with Cholecalciferol.Approved, Investigational
CabozantinibThe metabolism of Cabozantinib can be decreased when combined with Cholecalciferol.Approved
CaffeineThe metabolism of Caffeine can be decreased when combined with Cholecalciferol.Approved
Candesartan cilexetilThe metabolism of Candesartan can be decreased when combined with Cholecalciferol.Approved
CaptoprilThe metabolism of Captopril can be decreased when combined with Cholecalciferol.Approved
CarbamazepineThe metabolism of Cholecalciferol can be increased when combined with Carbamazepine.Approved, Investigational
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Cholecalciferol.Approved
CariprazineThe metabolism of Cariprazine can be decreased when combined with Cholecalciferol.Approved
CarisoprodolThe metabolism of Carisoprodol can be decreased when combined with Cholecalciferol.Approved
CarteololThe metabolism of Carteolol can be decreased when combined with Cholecalciferol.Approved
CarvedilolThe serum concentration of Carvedilol can be increased when it is combined with Cholecalciferol.Approved, Investigational
CelecoxibThe metabolism of Celecoxib can be decreased when combined with Cholecalciferol.Approved, Investigational
CephalexinThe metabolism of Cephalexin can be decreased when combined with Cholecalciferol.Approved, Vet Approved
CeritinibThe serum concentration of Cholecalciferol can be increased when it is combined with Ceritinib.Approved
CevimelineThe metabolism of Cevimeline can be decreased when combined with Cholecalciferol.Approved
ChloramphenicolThe metabolism of Chloramphenicol can be decreased when combined with Cholecalciferol.Approved, Vet Approved
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Cholecalciferol.Approved, Illicit
ChloroquineThe metabolism of Chloroquine can be decreased when combined with Cholecalciferol.Approved, Vet Approved
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Cholecalciferol.Approved
ChlorpromazineThe metabolism of Chlorpromazine can be decreased when combined with Cholecalciferol.Approved, Vet Approved
ChlorpropamideThe metabolism of Chlorpropamide can be decreased when combined with Cholecalciferol.Approved
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Cholecalciferol.Approved
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Cholecalciferol.Approved
CinnarizineThe metabolism of Cinnarizine can be decreased when combined with Cholecalciferol.Approved
CisaprideThe metabolism of Cisapride can be decreased when combined with Cholecalciferol.Approved, Investigational, Withdrawn
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Cholecalciferol.Approved
ClarithromycinThe metabolism of Cholecalciferol can be decreased when combined with Clarithromycin.Approved
ClemastineThe metabolism of Cholecalciferol can be decreased when combined with Clemastine.Approved
ClevidipineThe metabolism of Clevidipine can be decreased when combined with Cholecalciferol.Approved
ClobazamThe metabolism of Clobazam can be decreased when combined with Cholecalciferol.Approved, Illicit
clomethiazoleThe metabolism of clomethiazole can be decreased when combined with Cholecalciferol.Investigational
ClomipramineThe metabolism of Clomipramine can be decreased when combined with Cholecalciferol.Approved, Vet Approved
ClonidineThe metabolism of Clonidine can be decreased when combined with Cholecalciferol.Approved
ClopidogrelThe serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Cholecalciferol resulting in a loss in efficacy.Approved, Nutraceutical
ClotiazepamThe metabolism of Clotiazepam can be decreased when combined with Cholecalciferol.Approved, Illicit
ClotrimazoleThe metabolism of Cholecalciferol can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineThe metabolism of Clozapine can be decreased when combined with Cholecalciferol.Approved
CobicistatThe metabolism of Cholecalciferol can be decreased when combined with Cobicistat.Approved
CodeineThe therapeutic efficacy of Codeine can be decreased when used in combination with Cholecalciferol.Approved, Illicit
ConivaptanThe serum concentration of Cholecalciferol can be increased when it is combined with Conivaptan.Approved, Investigational
CrizotinibThe metabolism of Cholecalciferol can be decreased when combined with Crizotinib.Approved
CyclobenzaprineThe metabolism of Cyclobenzaprine can be decreased when combined with Cholecalciferol.Approved
CyclophosphamideThe metabolism of Cyclophosphamide can be decreased when combined with Cholecalciferol.Approved, Investigational
CyclosporineThe metabolism of Cholecalciferol can be decreased when combined with Cyclosporine.Approved, Investigational, Vet Approved
DabrafenibThe serum concentration of Cholecalciferol can be decreased when it is combined with Dabrafenib.Approved
DapagliflozinThe metabolism of Dapagliflozin can be decreased when combined with Cholecalciferol.Approved
DapsoneThe metabolism of Dapsone can be decreased when combined with Cholecalciferol.Approved, Investigational
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Cholecalciferol.Approved, Investigational
DarunavirThe metabolism of Cholecalciferol can be decreased when combined with Darunavir.Approved
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Cholecalciferol.Approved
DasatinibThe serum concentration of Cholecalciferol can be increased when it is combined with Dasatinib.Approved, Investigational
DebrisoquinThe metabolism of Debrisoquin can be decreased when combined with Cholecalciferol.Approved
DeferasiroxThe serum concentration of Cholecalciferol can be decreased when it is combined with Deferasirox.Approved, Investigational
DelavirdineThe metabolism of Cholecalciferol can be decreased when combined with Delavirdine.Approved
DesipramineThe metabolism of Desipramine can be decreased when combined with Cholecalciferol.Approved
DeutetrabenazineThe metabolism of Deutetrabenazine can be decreased when combined with Cholecalciferol.Approved, Investigational
Dexchlorpheniramine maleateThe metabolism of Dexchlorpheniramine maleate can be decreased when combined with Cholecalciferol.Approved
DexfenfluramineThe metabolism of Dexfenfluramine can be decreased when combined with Cholecalciferol.Approved, Illicit, Withdrawn
DexlansoprazoleThe metabolism of Dexlansoprazole can be decreased when combined with Cholecalciferol.Approved
DexmethylphenidateThe metabolism of Dexmethylphenidate can be decreased when combined with Cholecalciferol.Approved
DextroamphetamineThe metabolism of Dextroamphetamine can be decreased when combined with Cholecalciferol.Approved, Illicit
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Cholecalciferol.Approved
DiazepamThe metabolism of Diazepam can be decreased when combined with Cholecalciferol.Approved, Illicit, Vet Approved
DiclofenacThe metabolism of Diclofenac can be decreased when combined with Cholecalciferol.Approved, Vet Approved
DicoumarolThe metabolism of Dicoumarol can be decreased when combined with Cholecalciferol.Approved
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Cholecalciferol.Approved, Illicit
DihydroergotamineThe metabolism of Cholecalciferol can be decreased when combined with Dihydroergotamine.Approved
DiltiazemThe metabolism of Cholecalciferol can be decreased when combined with Diltiazem.Approved
DiphenhydramineThe metabolism of Diphenhydramine can be decreased when combined with Cholecalciferol.Approved
DoconexentThe metabolism of Doconexent can be decreased when combined with Cholecalciferol.Investigational
DolasetronThe metabolism of Dolasetron can be decreased when combined with Cholecalciferol.Approved
DomperidoneThe metabolism of Domperidone can be decreased when combined with Cholecalciferol.Approved, Investigational, Vet Approved
DonepezilThe metabolism of Donepezil can be decreased when combined with Cholecalciferol.Approved
DopamineThe metabolism of Dopamine can be decreased when combined with Cholecalciferol.Approved
DorzolamideThe metabolism of Dorzolamide can be decreased when combined with Cholecalciferol.Approved
DoxazosinThe metabolism of Doxazosin can be decreased when combined with Cholecalciferol.Approved
DoxepinThe metabolism of Doxepin can be decreased when combined with Cholecalciferol.Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Cholecalciferol.Approved, Investigational
DoxorubicinThe metabolism of Doxorubicin can be decreased when combined with Cholecalciferol.Approved, Investigational
DoxycyclineThe metabolism of Cholecalciferol can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Cholecalciferol.Approved, Illicit
DronedaroneThe metabolism of Cholecalciferol can be decreased when combined with Dronedarone.Approved
DuloxetineThe metabolism of Duloxetine can be decreased when combined with Cholecalciferol.Approved
EletriptanThe metabolism of Eletriptan can be decreased when combined with Cholecalciferol.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Cholecalciferol.Approved
EnasidenibThe metabolism of Enasidenib can be decreased when combined with Cholecalciferol.Approved
EncainideThe metabolism of Encainide can be decreased when combined with Cholecalciferol.Approved, Withdrawn
EnclomipheneThe metabolism of Enclomiphene can be decreased when combined with Cholecalciferol.Investigational
EnfuvirtideThe metabolism of Enfuvirtide can be decreased when combined with Cholecalciferol.Approved, Investigational
EnzalutamideThe serum concentration of Cholecalciferol can be decreased when it is combined with Enzalutamide.Approved
EpinastineThe metabolism of Epinastine can be decreased when combined with Cholecalciferol.Approved, Investigational
EpoprostenolThe metabolism of Epoprostenol can be decreased when combined with Cholecalciferol.Approved
ErlotinibThe metabolism of Erlotinib can be decreased when combined with Cholecalciferol.Approved, Investigational
ErythromycinThe metabolism of Cholecalciferol can be decreased when combined with Erythromycin.Approved, Vet Approved
EscitalopramThe metabolism of Escitalopram can be decreased when combined with Cholecalciferol.Approved, Investigational
EsmirtazapineThe metabolism of Esmirtazapine can be decreased when combined with Cholecalciferol.Investigational
EsomeprazoleThe metabolism of Esomeprazole can be decreased when combined with Cholecalciferol.Approved, Investigational
EstradiolThe metabolism of Estradiol can be decreased when combined with Cholecalciferol.Approved, Investigational, Vet Approved
EstroneThe metabolism of Estrone can be decreased when combined with Cholecalciferol.Approved
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Cholecalciferol.Approved
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Cholecalciferol.Approved, Illicit
EtizolamThe metabolism of Etizolam can be decreased when combined with Cholecalciferol.Approved
EtodolacThe metabolism of Etodolac can be decreased when combined with Cholecalciferol.Approved, Investigational, Vet Approved
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Cholecalciferol.Approved, Investigational
EtravirineThe metabolism of Etravirine can be decreased when combined with Cholecalciferol.Approved
FamotidineThe metabolism of Famotidine can be decreased when combined with Cholecalciferol.Approved
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Cholecalciferol.Approved
FingolimodThe metabolism of Fingolimod can be decreased when combined with Cholecalciferol.Approved, Investigational
FlecainideThe metabolism of Flecainide can be decreased when combined with Cholecalciferol.Approved, Withdrawn
FluconazoleThe metabolism of Cholecalciferol can be decreased when combined with Fluconazole.Approved
FlunarizineThe metabolism of Flunarizine can be decreased when combined with Cholecalciferol.Approved
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Cholecalciferol.Approved, Illicit
FluoxetineThe metabolism of Fluoxetine can be decreased when combined with Cholecalciferol.Approved, Vet Approved
FluphenazineThe metabolism of Fluphenazine can be decreased when combined with Cholecalciferol.Approved
FlurbiprofenThe metabolism of Flurbiprofen can be decreased when combined with Cholecalciferol.Approved, Investigational
FlutamideThe metabolism of Flutamide can be decreased when combined with Cholecalciferol.Approved
FluvastatinThe metabolism of Fluvastatin can be decreased when combined with Cholecalciferol.Approved
FluvoxamineThe metabolism of Cholecalciferol can be decreased when combined with Fluvoxamine.Approved, Investigational
FormoterolThe metabolism of Formoterol can be decreased when combined with Cholecalciferol.Approved, Investigational
FosamprenavirThe metabolism of Cholecalciferol can be decreased when combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Cholecalciferol can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinThe metabolism of Cholecalciferol can be increased when combined with Fosphenytoin.Approved
Fusidic AcidThe serum concentration of Cholecalciferol can be increased when it is combined with Fusidic Acid.Approved
GalantamineThe metabolism of Galantamine can be decreased when combined with Cholecalciferol.Approved
GavestinelThe metabolism of Gavestinel can be decreased when combined with Cholecalciferol.Investigational
GefitinibThe metabolism of Gefitinib can be decreased when combined with Cholecalciferol.Approved, Investigational
GliclazideThe metabolism of Gliclazide can be decreased when combined with Cholecalciferol.Approved
GlimepirideThe metabolism of Glimepiride can be decreased when combined with Cholecalciferol.Approved
GlipizideThe metabolism of Glipizide can be decreased when combined with Cholecalciferol.Approved
GlucosamineThe metabolism of Glucosamine can be decreased when combined with Cholecalciferol.Approved
GlyburideThe metabolism of Glyburide can be decreased when combined with Cholecalciferol.Approved
GranisetronThe metabolism of Granisetron can be decreased when combined with Cholecalciferol.Approved, Investigational
GuanfacineThe metabolism of Guanfacine can be decreased when combined with Cholecalciferol.Approved, Investigational
HalofantrineThe metabolism of Halofantrine can be decreased when combined with Cholecalciferol.Approved
HaloperidolThe metabolism of Haloperidol can be decreased when combined with Cholecalciferol.Approved
HalothaneThe metabolism of Halothane can be decreased when combined with Cholecalciferol.Approved, Vet Approved
HexobarbitalThe metabolism of Hexobarbital can be decreased when combined with Cholecalciferol.Approved
HistamineThe metabolism of Histamine can be decreased when combined with Cholecalciferol.Approved, Investigational
HydrocodoneThe metabolism of Hydrocodone can be decreased when combined with Cholecalciferol.Approved, Illicit
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Cholecalciferol.Approved, Illicit
IbrutinibThe metabolism of Ibrutinib can be decreased when combined with Cholecalciferol.Approved
IbuprofenThe metabolism of Ibuprofen can be decreased when combined with Cholecalciferol.Approved
IdarubicinThe metabolism of Idarubicin can be decreased when combined with Cholecalciferol.Approved
IdelalisibThe serum concentration of Cholecalciferol can be increased when it is combined with Idelalisib.Approved
IfosfamideThe metabolism of Ifosfamide can be decreased when combined with Cholecalciferol.Approved
IloperidoneThe metabolism of Iloperidone can be decreased when combined with Cholecalciferol.Approved
ImatinibThe metabolism of Cholecalciferol can be decreased when combined with Imatinib.Approved
ImipramineThe metabolism of Imipramine can be decreased when combined with Cholecalciferol.Approved
IndinavirThe metabolism of Cholecalciferol can be decreased when combined with Indinavir.Approved
indisulamThe metabolism of indisulam can be decreased when combined with Cholecalciferol.Investigational
IndomethacinThe metabolism of Indomethacin can be decreased when combined with Cholecalciferol.Approved, Investigational
Ipratropium bromideThe metabolism of Ipratropium bromide can be decreased when combined with Cholecalciferol.Approved
IrbesartanThe metabolism of Irbesartan can be decreased when combined with Cholecalciferol.Approved, Investigational
IsavuconazoniumThe metabolism of Cholecalciferol can be decreased when combined with Isavuconazonium.Approved, Investigational
IsradipineThe metabolism of Cholecalciferol can be decreased when combined with Isradipine.Approved
ItraconazoleThe metabolism of Cholecalciferol can be decreased when combined with Itraconazole.Approved, Investigational
IvacaftorThe serum concentration of Cholecalciferol can be increased when it is combined with Ivacaftor.Approved
IxazomibThe metabolism of Ixazomib can be decreased when combined with Cholecalciferol.Approved
KetamineThe metabolism of Ketamine can be decreased when combined with Cholecalciferol.Approved, Vet Approved
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Cholecalciferol.Approved
KetoconazoleThe metabolism of Cholecalciferol can be decreased when combined with Ketoconazole.Approved, Investigational
KetoprofenThe metabolism of Ketoprofen can be decreased when combined with Cholecalciferol.Approved, Vet Approved
LabetalolThe metabolism of Labetalol can be decreased when combined with Cholecalciferol.Approved
LansoprazoleThe metabolism of Lansoprazole can be decreased when combined with Cholecalciferol.Approved, Investigational
LapatinibThe metabolism of Lapatinib can be decreased when combined with Cholecalciferol.Approved, Investigational
LeflunomideThe metabolism of Leflunomide can be decreased when combined with Cholecalciferol.Approved, Investigational
LesinuradThe metabolism of Lesinurad can be decreased when combined with Cholecalciferol.Approved
LevodopaThe metabolism of Levodopa can be decreased when combined with Cholecalciferol.Approved
LevomilnacipranThe metabolism of Levomilnacipran can be decreased when combined with Cholecalciferol.Approved
LicofeloneThe metabolism of Licofelone can be decreased when combined with Cholecalciferol.Investigational
LidocaineThe metabolism of Lidocaine can be decreased when combined with Cholecalciferol.Approved, Vet Approved
LisurideThe metabolism of Lisuride can be decreased when combined with Cholecalciferol.Approved
LomustineThe metabolism of Lomustine can be decreased when combined with Cholecalciferol.Approved
LoperamideThe metabolism of Loperamide can be decreased when combined with Cholecalciferol.Approved
LopinavirThe metabolism of Cholecalciferol can be decreased when combined with Lopinavir.Approved
LoratadineThe metabolism of Loratadine can be decreased when combined with Cholecalciferol.Approved
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Cholecalciferol.Approved
LornoxicamThe metabolism of Lornoxicam can be decreased when combined with Cholecalciferol.Approved
LosartanThe metabolism of Losartan can be decreased when combined with Cholecalciferol.Approved
LovastatinThe metabolism of Cholecalciferol can be decreased when combined with Lovastatin.Approved, Investigational
LuliconazoleThe serum concentration of Cholecalciferol can be increased when it is combined with Luliconazole.Approved
LumacaftorThe metabolism of Cholecalciferol can be increased when combined with Lumacaftor.Approved
LumiracoxibThe metabolism of Lumiracoxib can be decreased when combined with Cholecalciferol.Approved, Investigational
MacitentanThe metabolism of Macitentan can be decreased when combined with Cholecalciferol.Approved
MaprotilineThe metabolism of Maprotiline can be decreased when combined with Cholecalciferol.Approved
Mefenamic acidThe metabolism of Mefenamic acid can be decreased when combined with Cholecalciferol.Approved
MelatoninThe metabolism of Melatonin can be decreased when combined with Cholecalciferol.Approved, Nutraceutical, Vet Approved
MeloxicamThe metabolism of Meloxicam can be decreased when combined with Cholecalciferol.Approved, Vet Approved
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Cholecalciferol.Investigational, Withdrawn
MeprobamateThe metabolism of Meprobamate can be decreased when combined with Cholecalciferol.Approved, Illicit
MequitazineThe metabolism of Mequitazine can be decreased when combined with Cholecalciferol.Approved
MesoridazineThe metabolism of Mesoridazine can be decreased when combined with Cholecalciferol.Approved
MestranolThe metabolism of Mestranol can be decreased when combined with Cholecalciferol.Approved
MethadoneThe metabolism of Methadone can be decreased when combined with Cholecalciferol.Approved
MethamphetamineThe metabolism of Methamphetamine can be decreased when combined with Cholecalciferol.Approved, Illicit
MethotrimeprazineThe metabolism of Methotrimeprazine can be decreased when combined with Cholecalciferol.Approved
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Cholecalciferol.Approved, Vet Approved
MethsuximideThe metabolism of Methsuximide can be decreased when combined with Cholecalciferol.Approved
MethylphenidateThe metabolism of Methylphenidate can be decreased when combined with Cholecalciferol.Approved, Investigational
MethylphenobarbitalThe metabolism of Methylphenobarbital can be decreased when combined with Cholecalciferol.Approved
MethyprylonThe metabolism of Methyprylon can be decreased when combined with Cholecalciferol.Approved, Illicit, Withdrawn
MetoclopramideThe metabolism of Metoclopramide can be decreased when combined with Cholecalciferol.Approved, Investigational
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Cholecalciferol.Approved, Investigational
MetronidazoleThe metabolism of Metronidazole can be decreased when combined with Cholecalciferol.Approved
MexiletineThe metabolism of Mexiletine can be decreased when combined with Cholecalciferol.Approved
MianserinThe metabolism of Mianserin can be decreased when combined with Cholecalciferol.Approved
MifepristoneThe serum concentration of Cholecalciferol can be increased when it is combined with Mifepristone.Approved, Investigational
MinaprineThe metabolism of Minaprine can be decreased when combined with Cholecalciferol.Approved
MirabegronThe metabolism of Mirabegron can be decreased when combined with Cholecalciferol.Approved
MirtazapineThe metabolism of Mirtazapine can be decreased when combined with Cholecalciferol.Approved
MitotaneThe serum concentration of Cholecalciferol can be decreased when it is combined with Mitotane.Approved
MoclobemideThe metabolism of Moclobemide can be decreased when combined with Cholecalciferol.Approved
MontelukastThe metabolism of Montelukast can be decreased when combined with Cholecalciferol.Approved
MorphineThe metabolism of Morphine can be decreased when combined with Cholecalciferol.Approved, Investigational
NaproxenThe metabolism of Naproxen can be decreased when combined with Cholecalciferol.Approved, Vet Approved
NateglinideThe metabolism of Nateglinide can be decreased when combined with Cholecalciferol.Approved, Investigational
NebivololThe serum concentration of Nebivolol can be increased when it is combined with Cholecalciferol.Approved, Investigational
NefazodoneThe metabolism of Cholecalciferol can be decreased when combined with Nefazodone.Approved, Withdrawn
NelfinavirThe metabolism of Cholecalciferol can be decreased when combined with Nelfinavir.Approved
NetupitantThe serum concentration of Cholecalciferol can be increased when it is combined with Netupitant.Approved
NevirapineThe metabolism of Cholecalciferol can be increased when combined with Nevirapine.Approved
NicardipineThe metabolism of Nicardipine can be decreased when combined with Cholecalciferol.Approved
NicergolineThe metabolism of Nicergoline can be decreased when combined with Cholecalciferol.Approved
NiclosamideThe metabolism of Niclosamide can be decreased when combined with Cholecalciferol.Approved, Vet Approved
NicotineThe metabolism of Nicotine can be decreased when combined with Cholecalciferol.Approved
NifedipineThe metabolism of Nifedipine can be decreased when combined with Cholecalciferol.Approved
NilotinibThe metabolism of Cholecalciferol can be decreased when combined with Nilotinib.Approved, Investigational
NilutamideThe metabolism of Nilutamide can be decreased when combined with Cholecalciferol.Approved
NitrofuralThe metabolism of Nitrofural can be decreased when combined with Cholecalciferol.Approved, Vet Approved
NortriptylineThe metabolism of Nortriptyline can be decreased when combined with Cholecalciferol.Approved
OlanzapineThe metabolism of Olanzapine can be decreased when combined with Cholecalciferol.Approved, Investigational
OlaparibThe metabolism of Cholecalciferol can be decreased when combined with Olaparib.Approved
OlodaterolThe metabolism of Olodaterol can be decreased when combined with Cholecalciferol.Approved
OmeprazoleThe metabolism of Omeprazole can be decreased when combined with Cholecalciferol.Approved, Investigational, Vet Approved
OndansetronThe metabolism of Ondansetron can be decreased when combined with Cholecalciferol.Approved
OsimertinibThe serum concentration of Cholecalciferol can be increased when it is combined with Osimertinib.Approved
OspemifeneThe metabolism of Ospemifene can be decreased when combined with Cholecalciferol.Approved
OxaprozinThe metabolism of Oxaprozin can be decreased when combined with Cholecalciferol.Approved
OxiconazoleThe metabolism of Oxiconazole can be decreased when combined with Cholecalciferol.Approved
OxycodoneThe metabolism of Oxycodone can be decreased when combined with Cholecalciferol.Approved, Illicit, Investigational
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Cholecalciferol.Approved, Investigational, Vet Approved
PaclitaxelThe metabolism of Paclitaxel can be decreased when combined with Cholecalciferol.Approved, Vet Approved
PalbociclibThe serum concentration of Cholecalciferol can be increased when it is combined with Palbociclib.Approved
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Cholecalciferol.Approved, Investigational
PantoprazoleThe metabolism of Pantoprazole can be decreased when combined with Cholecalciferol.Approved
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Cholecalciferol.Approved
ParecoxibThe metabolism of Parecoxib can be decreased when combined with Cholecalciferol.Approved
ParoxetineThe metabolism of Paroxetine can be decreased when combined with Cholecalciferol.Approved, Investigational
PazopanibThe metabolism of Pazopanib can be decreased when combined with Cholecalciferol.Approved
PentamidineThe metabolism of Pentamidine can be decreased when combined with Cholecalciferol.Approved
PentobarbitalThe metabolism of Cholecalciferol can be increased when combined with Pentobarbital.Approved, Vet Approved
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Cholecalciferol.Approved
PerospironeThe metabolism of Perospirone can be decreased when combined with Cholecalciferol.Approved
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Cholecalciferol.Approved
PethidineThe metabolism of Pethidine can be decreased when combined with Cholecalciferol.Approved
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Cholecalciferol.Withdrawn
PhenforminThe metabolism of Phenformin can be decreased when combined with Cholecalciferol.Approved, Withdrawn
PhenobarbitalThe metabolism of Cholecalciferol can be increased when combined with Phenobarbital.Approved
PhenprocoumonThe metabolism of Phenprocoumon can be decreased when combined with Cholecalciferol.Approved
PhenylbutazoneThe metabolism of Phenylbutazone can be decreased when combined with Cholecalciferol.Approved, Vet Approved
PhenytoinThe metabolism of Cholecalciferol can be increased when combined with Phenytoin.Approved, Vet Approved
PindololThe metabolism of Pindolol can be decreased when combined with Cholecalciferol.Approved
PioglitazoneThe metabolism of Pioglitazone can be decreased when combined with Cholecalciferol.Approved, Investigational
PiperazineThe metabolism of Piperazine can be decreased when combined with Cholecalciferol.Approved, Vet Approved
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Cholecalciferol.Approved
PiroxicamThe metabolism of Piroxicam can be decreased when combined with Cholecalciferol.Approved, Investigational
PitavastatinThe metabolism of Pitavastatin can be decreased when combined with Cholecalciferol.Approved
PodofiloxThe metabolism of Podofilox can be decreased when combined with Cholecalciferol.Approved
PonatinibThe metabolism of Ponatinib can be decreased when combined with Cholecalciferol.Approved
PosaconazoleThe metabolism of Cholecalciferol can be decreased when combined with Posaconazole.Approved, Investigational, Vet Approved
PrasugrelThe metabolism of Prasugrel can be decreased when combined with Cholecalciferol.Approved
PravastatinThe metabolism of Pravastatin can be decreased when combined with Cholecalciferol.Approved
PraziquantelThe metabolism of Praziquantel can be decreased when combined with Cholecalciferol.Approved, Vet Approved
PrimidoneThe metabolism of Cholecalciferol can be increased when combined with Primidone.Approved, Vet Approved
ProcainamideThe metabolism of Procainamide can be decreased when combined with Cholecalciferol.Approved
ProchlorperazineThe metabolism of Prochlorperazine can be decreased when combined with Cholecalciferol.Approved, Vet Approved
ProgesteroneThe metabolism of Progesterone can be decreased when combined with Cholecalciferol.Approved, Vet Approved
ProguanilThe metabolism of Proguanil can be decreased when combined with Cholecalciferol.Approved
PromazineThe metabolism of Promazine can be decreased when combined with Cholecalciferol.Approved, Vet Approved
PromethazineThe metabolism of Promethazine can be decreased when combined with Cholecalciferol.Approved
PropafenoneThe serum concentration of Cholecalciferol can be increased when it is combined with Propafenone.Approved
PropofolThe metabolism of Propofol can be decreased when combined with Cholecalciferol.Approved, Investigational, Vet Approved
PropranololThe metabolism of Propranolol can be decreased when combined with Cholecalciferol.Approved, Investigational
ProtriptylineThe metabolism of Protriptyline can be decreased when combined with Cholecalciferol.Approved
PseudoephedrineThe metabolism of Pseudoephedrine can be decreased when combined with Cholecalciferol.Approved
QuazepamThe metabolism of Quazepam can be decreased when combined with Cholecalciferol.Approved, Illicit
QuetiapineThe metabolism of Quetiapine can be decreased when combined with Cholecalciferol.Approved
QuinidineThe metabolism of Quinidine can be decreased when combined with Cholecalciferol.Approved
QuinineThe metabolism of Quinine can be decreased when combined with Cholecalciferol.Approved
RabeprazoleThe metabolism of Rabeprazole can be decreased when combined with Cholecalciferol.Approved, Investigational
RamelteonThe metabolism of Ramelteon can be decreased when combined with Cholecalciferol.Approved, Investigational
RanitidineThe metabolism of Ranitidine can be decreased when combined with Cholecalciferol.Approved
RanolazineThe metabolism of Cholecalciferol can be decreased when combined with Ranolazine.Approved, Investigational
RemoxiprideThe metabolism of Remoxipride can be decreased when combined with Cholecalciferol.Approved, Withdrawn
repinotanThe metabolism of repinotan can be decreased when combined with Cholecalciferol.Investigational
RifabutinThe metabolism of Cholecalciferol can be increased when combined with Rifabutin.Approved
RifampicinThe metabolism of Cholecalciferol can be increased when combined with Rifampicin.Approved
RifapentineThe metabolism of Cholecalciferol can be increased when combined with Rifapentine.Approved
RisperidoneThe metabolism of Risperidone can be decreased when combined with Cholecalciferol.Approved, Investigational
RitonavirThe metabolism of Cholecalciferol can be decreased when combined with Ritonavir.Approved, Investigational
RofecoxibThe metabolism of Rofecoxib can be decreased when combined with Cholecalciferol.Investigational, Withdrawn
RomidepsinThe metabolism of Romidepsin can be decreased when combined with Cholecalciferol.Approved, Investigational
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Cholecalciferol.Approved
RosiglitazoneThe metabolism of Rosiglitazone can be decreased when combined with Cholecalciferol.Approved, Investigational
RosuvastatinThe metabolism of Rosuvastatin can be decreased when combined with Cholecalciferol.Approved
RotigotineThe metabolism of Rotigotine can be decreased when combined with Cholecalciferol.Approved
RucaparibThe metabolism of Rucaparib can be decreased when combined with Cholecalciferol.Approved, Investigational
RupatadineThe metabolism of Rupatadine can be decreased when combined with Cholecalciferol.Approved
Salicylic acidThe metabolism of Salicylic acid can be decreased when combined with Cholecalciferol.Approved, Vet Approved
SaquinavirThe metabolism of Cholecalciferol can be decreased when combined with Saquinavir.Approved, Investigational
SelegilineThe metabolism of Selegiline can be decreased when combined with Cholecalciferol.Approved, Investigational, Vet Approved
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Cholecalciferol.Approved
SertindoleThe metabolism of Sertindole can be decreased when combined with Cholecalciferol.Approved, Withdrawn
SertralineThe metabolism of Sertraline can be decreased when combined with Cholecalciferol.Approved
SildenafilThe metabolism of Cholecalciferol can be decreased when combined with Sildenafil.Approved, Investigational
SiltuximabThe serum concentration of Cholecalciferol can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Cholecalciferol can be increased when it is combined with Simeprevir.Approved
SimvastatinThe metabolism of Simvastatin can be decreased when combined with Cholecalciferol.Approved
SitaxentanThe metabolism of Sitaxentan can be decreased when combined with Cholecalciferol.Approved, Investigational, Withdrawn
SparteineThe metabolism of Sparteine can be decreased when combined with Cholecalciferol.Experimental
St. John's WortThe serum concentration of Cholecalciferol can be decreased when it is combined with St. John's Wort.Nutraceutical
StiripentolThe serum concentration of Cholecalciferol can be increased when it is combined with Stiripentol.Approved
SulfadiazineThe metabolism of Sulfadiazine can be decreased when combined with Cholecalciferol.Approved, Vet Approved
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be decreased when combined with Cholecalciferol.Approved
SulfamoxoleThe metabolism of Sulfamoxole can be decreased when combined with Cholecalciferol.Approved
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be decreased when combined with Cholecalciferol.Approved
SulfisoxazoleThe metabolism of Cholecalciferol can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
SuprofenThe metabolism of Suprofen can be decreased when combined with Cholecalciferol.Approved, Withdrawn
TamoxifenThe serum concentration of the active metabolites of Tamoxifen can be reduced when Tamoxifen is used in combination with Cholecalciferol resulting in a loss in efficacy.Approved
TamsulosinThe metabolism of Tamsulosin can be decreased when combined with Cholecalciferol.Approved, Investigational
TapentadolThe metabolism of Tapentadol can be decreased when combined with Cholecalciferol.Approved
TegaserodThe metabolism of Tegaserod can be decreased when combined with Cholecalciferol.Investigational, Withdrawn
TelaprevirThe metabolism of Cholecalciferol can be decreased when combined with Telaprevir.Withdrawn
TelithromycinThe metabolism of Cholecalciferol can be decreased when combined with Telithromycin.Approved
TemazepamThe metabolism of Temazepam can be decreased when combined with Cholecalciferol.Approved
TeniposideThe metabolism of Teniposide can be decreased when combined with Cholecalciferol.Approved
TenoxicamThe metabolism of Tenoxicam can be decreased when combined with Cholecalciferol.Approved
TerbinafineThe metabolism of Terbinafine can be decreased when combined with Cholecalciferol.Approved, Investigational, Vet Approved
TerfenadineThe metabolism of Terfenadine can be decreased when combined with Cholecalciferol.Withdrawn
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Cholecalciferol.Investigational
TestosteroneThe metabolism of Testosterone can be decreased when combined with Cholecalciferol.Approved, Investigational
TetrabenazineThe metabolism of Tetrabenazine can be decreased when combined with Cholecalciferol.Approved
ThalidomideThe metabolism of Thalidomide can be decreased when combined with Cholecalciferol.Approved, Investigational, Withdrawn
TheophyllineThe metabolism of Theophylline can be decreased when combined with Cholecalciferol.Approved
ThiamylalThe metabolism of Thiamylal can be decreased when combined with Cholecalciferol.Approved, Vet Approved
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Cholecalciferol.Withdrawn
TiclopidineThe metabolism of Cholecalciferol can be decreased when combined with Ticlopidine.Approved
TimololThe metabolism of Timolol can be decreased when combined with Cholecalciferol.Approved
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Cholecalciferol.Approved
TipranavirThe metabolism of Tipranavir can be decreased when combined with Cholecalciferol.Approved, Investigational
TocilizumabThe serum concentration of Cholecalciferol can be decreased when it is combined with Tocilizumab.Approved
TofacitinibThe metabolism of Tofacitinib can be decreased when combined with Cholecalciferol.Approved, Investigational
TolbutamideThe metabolism of Tolbutamide can be decreased when combined with Cholecalciferol.Approved
TolterodineThe metabolism of Tolterodine can be decreased when combined with Cholecalciferol.Approved, Investigational
TorasemideThe metabolism of Torasemide can be decreased when combined with Cholecalciferol.Approved
TrabectedinThe metabolism of Trabectedin can be decreased when combined with Cholecalciferol.Approved, Investigational
TramadolThe therapeutic efficacy of Tramadol can be decreased when used in combination with Cholecalciferol.Approved, Investigational
TrazodoneThe metabolism of Trazodone can be decreased when combined with Cholecalciferol.Approved, Investigational
TreprostinilThe metabolism of Treprostinil can be decreased when combined with Cholecalciferol.Approved, Investigational
TretinoinThe metabolism of Tretinoin can be decreased when combined with Cholecalciferol.Approved, Investigational, Nutraceutical
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Cholecalciferol.Approved
TrimethoprimThe metabolism of Trimethoprim can be decreased when combined with Cholecalciferol.Approved, Vet Approved
TrimipramineThe metabolism of Trimipramine can be decreased when combined with Cholecalciferol.Approved
TroglitazoneThe metabolism of Troglitazone can be decreased when combined with Cholecalciferol.Withdrawn
UmeclidiniumThe metabolism of Umeclidinium can be decreased when combined with Cholecalciferol.Approved
ValbenazineThe metabolism of Valbenazine can be decreased when combined with Cholecalciferol.Approved, Investigational
ValdecoxibThe metabolism of Valdecoxib can be decreased when combined with Cholecalciferol.Investigational, Withdrawn
Valproic AcidThe metabolism of Valproic Acid can be decreased when combined with Cholecalciferol.Approved, Investigational
ValsartanThe metabolism of Valsartan can be decreased when combined with Cholecalciferol.Approved, Investigational
VenlafaxineThe metabolism of Cholecalciferol can be decreased when combined with Venlafaxine.Approved
VerapamilThe metabolism of Cholecalciferol can be decreased when combined with Verapamil.Approved
VernakalantThe metabolism of Vernakalant can be decreased when combined with Cholecalciferol.Approved, Investigational
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Cholecalciferol.Investigational
VilazodoneThe metabolism of Vilazodone can be decreased when combined with Cholecalciferol.Approved
VinblastineThe metabolism of Vinblastine can be decreased when combined with Cholecalciferol.Approved
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Cholecalciferol.Approved, Investigational
VismodegibThe metabolism of Vismodegib can be decreased when combined with Cholecalciferol.Approved
VoriconazoleThe metabolism of Cholecalciferol can be decreased when combined with Voriconazole.Approved, Investigational
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Cholecalciferol.Approved
WarfarinThe metabolism of Warfarin can be decreased when combined with Cholecalciferol.Approved
XimelagatranThe metabolism of Ximelagatran can be decreased when combined with Cholecalciferol.Approved, Investigational, Withdrawn
YohimbineThe metabolism of Yohimbine can be decreased when combined with Cholecalciferol.Approved, Vet Approved
ZafirlukastThe metabolism of Zafirlukast can be decreased when combined with Cholecalciferol.Approved, Investigational
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Cholecalciferol.Approved
ZaltoprofenThe metabolism of Zaltoprofen can be decreased when combined with Cholecalciferol.Approved
ZidovudineThe metabolism of Zidovudine can be decreased when combined with Cholecalciferol.Approved
ZileutonThe metabolism of Zileuton can be decreased when combined with Cholecalciferol.Approved, Investigational, Withdrawn
ZiprasidoneThe metabolism of Cholecalciferol can be decreased when combined with Ziprasidone.Approved
ZolpidemThe metabolism of Zolpidem can be decreased when combined with Cholecalciferol.Approved
ZopicloneThe metabolism of Zopiclone can be decreased when combined with Cholecalciferol.Approved
ZuclopenthixolThe metabolism of Zuclopenthixol can be decreased when combined with Cholecalciferol.Approved, Investigational
Food Interactions
Not Available

References

Synthesis Reference

Jean Jolly, Primo Rizzi, Jean Taillardat, "1.alpha.,25.alpha.-Dihydroxy-cholecalciferol and methods for the production thereof." U.S. Patent US4435325, issued May, 1977.

US4435325
General References
  1. Armas LA, Hollis BW, Heaney RP: Vitamin D2 is much less effective than vitamin D3 in humans. J Clin Endocrinol Metab. 2004 Nov;89(11):5387-91. [PubMed:15531486]
External Links
Human Metabolome Database
HMDB14315
KEGG Drug
D00188
KEGG Compound
C05443
ChemSpider
4444353
ChEBI
28940
ChEMBL
CHEMBL1042
Therapeutic Targets Database
DAP001273
PharmGKB
PA164748138
HET
VD3
Drugs.com
Drugs.com Drug Page
PDRhealth
PDRhealth Drug Page
Wikipedia
Cholecalciferol
ATC Codes
M05BB08 — Zoledronic acid, calcium and colecalciferol, sequentialA11CC05 — ColecalciferolM05BB04 — Risedronic acid, calcium and colecalciferol, sequentialM05BB05 — Alendronic acid, calcium and colecalciferol, sequentialM05BB03 — Alendronic acid and colecalciferolM05BX53 — Strontium ranelate and colecalciferolM05BB07 — Risedronic acid and colecalciferol
AHFS Codes
  • 92:24.00 — Bone Resorption Inhibitors
  • 84:24.00 — Emollients Demulcents and Protectants
  • 88:29.00* — Minerals
  • 84:04.92 — Miscellaneous Local Anti-infectives
  • 88:28.00 — Multivitamin Preparations
  • 40:12.00 — Replacement Preparations
  • 88:04.00 — Vitamin A
  • 88:04.01* — Vitamin a and D
  • 88:12.00 — Vitamin C
  • 88:16.00 — Vitamin D
  • 88:28.01* — Vitamins & Minerals
MSDS
Download (123 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0Active Not RecruitingPreventionDeficiency, Vitamin D1
0CompletedPreventionGingival Inflammation1
0CompletedPreventionLong Segment Barrett's Esophagus / Short Segment Barrett's Esophagus1
0CompletedTreatmentChronic Kidney Disease (CKD)1
0RecruitingBasic ScienceStage I-III Colon Cancer / Stage IV Colon Cancer With Resectable Liver Metastases / Stage, Colon Cancer1
0Unknown StatusPreventionDeficiency, Vitamin D / Periodontal Diseases1
1CompletedNot AvailableHealthy Volunteers1
1CompletedNot AvailableHuman Immunodeficiency Virus (HIV) Infections / Infection, Human Immunodeficiency Virus I / Mycobacterium avium complex infection1
1CompletedBasic ScienceHealthy Volunteers1
1CompletedDiagnosticHealthy Volunteers1
1CompletedHealth Services ResearchDeficiency, Vitamin D1
1CompletedPreventionCancer, Breast1
1CompletedPreventionHIV / AIDS1
1CompletedPreventionHealthy, no Evidence of Disease / Skin Cancers1
1CompletedTreatmentAcute and Chronic Inflammation / Autoimmune Diseases / Disorder of Pleura and Pleural Cavity / Disorder of Synovium / Felty's Syndrome / Rheumatoid Arthritis / Rheumatoid Nodules / Sjögren's Syndrome1
1CompletedTreatmentCalcium Deficiency / Deficiency, Vitamin D1
1CompletedTreatmentCancers / Metastases1
1CompletedTreatmentDeficiency, Vitamin D1
1CompletedTreatmentDeficiency, Vitamin D / Disseminated Sclerosis1
1CompletedTreatmentSystemic Lupus Erythematosus (SLE)1
1CompletedTreatmentType 2 Diabetes Mellitus1
1Not Yet RecruitingBasic ScienceAging / Mineral deficiency / Vitamin Deficiency1
1RecruitingTreatmentAdult Women / Estrogen Receptor Positive / Metastatic Breast Cancer (MBC)1
1RecruitingTreatmentPneumonia1
1RecruitingTreatmentSarcopenia1
1, 2Active Not RecruitingTreatmentDeficiency, Vitamin D1
1, 2CompletedPreventionBiomarker Change Linked to Breast Cancer1
1, 2CompletedPreventionCancer, Breast1
1, 2CompletedPreventionDeficiency, Vitamin D / Prophylaxis of preeclampsia1
1, 2CompletedPreventionPrimary Immune Deficiency Disorders (PIDD)1
1, 2CompletedTreatmentDeficiency, Vitamin D / Spinal Cord Injuries (SCI)1
1, 2CompletedTreatmentHuman Immunodeficiency Virus (HIV)1
1, 2CompletedTreatmentSickle Cell Disorders1
1, 2Not Yet RecruitingTreatmentDiabetes, Gestational1
1, 2RecruitingTreatmentCancer, Breast / Ductal Carcinoma In-situ / Invasive Breast Carcinoma1
1, 2RecruitingTreatmentCrohn's Disease (CD) / Deficiency, Vitamin D1
1, 2RecruitingTreatmentDeficiency, Vitamin D1
1, 2SuspendedTreatmentSchizoaffective Disorders / Schizophrenic Disorders1
1, 2Unknown StatusTreatmentGlioblastoma Multiforme1
1, 2WithdrawnTreatmentUlcerative Colitis (UC)1
2Active Not RecruitingPreventionBone Loss / Calcifications, Vascular / End Stage Renal Disease (ESRD) / Fracture Bone / Transplantation, Kidney1
2Active Not RecruitingTreatmentAcute Chest Syndrome / Asthma Bronchial / Deficiency, Vitamin D / Respiratory Tract Infections (RTI) / Sickle Cell Disorders1
2Active Not RecruitingTreatmentBone Diseases / Diabetic Nephropathies / Sub-optimal Vitamin D Status1
2Active Not RecruitingTreatmentCholecalciferol Toxicity / Methicillin Resistant Staphylococcus Aureus (MRSA) / Resistant Staphylococcus Aureus: [Methicillin] or [Multiple] / Staphylococcus Aureus Infections / Vitamin D3 Deficiency1
2CompletedBasic ScienceInsulin Sensitivity / Intraocular Pressure1
2CompletedBasic ScienceProstate Cancer1
2CompletedBasic ScienceType 2 Diabetes Mellitus / Vitamin D Insufficiency1
2CompletedDiagnosticHypersensitivity1
2CompletedPreventionAtherosclerosis / Systemic Lupus Erythematosus (SLE)1
2CompletedPreventionAutistic Disorder1
2CompletedPreventionCancer, Breast1
2CompletedPreventionCancer, Ovarian1
2CompletedPreventionColorectal Cancers1
2CompletedPreventionHuman Immunodeficiency Virus (HIV) Infections1
2CompletedSupportive CareArthralgia / Muscle pains1
2CompletedTreatmentAcquired Immune Deficiency Syndrome (AIDS) / Human Immunodeficiency Virus (HIV) Infections1
2CompletedTreatmentAdenocarcinoma, Prostate / Stage I Prostate Cancer / Stage IIA Prostate Cancer / Stage IIB Prostate Cancer1
2CompletedTreatmentAllergic Rhinoconjunctivitis1
2CompletedTreatmentAtopic Dermatitis (AD) / Psoriasis1
2CompletedTreatmentAutism, Early Infantile1
2CompletedTreatmentBMI >30 kg/m21
2CompletedTreatmentCancer, Breast1
2CompletedTreatmentChronic Heart Failure (CHF)1
2CompletedTreatmentChronic Kidney Disease (CKD)1
2CompletedTreatmentCongestive Heart Failure (CHF) / Deficiency, Vitamin D / Heart Failure, Unspecified / Prophylaxis of cardiomyopathy1
2CompletedTreatmentCrohn's Disease (CD)1
2CompletedTreatmentDeficiency, Vitamin D / Homocystinaemia1
2CompletedTreatmentDeficiency, Vitamin D / Human Immunodeficiency Virus (HIV) / Hyperparathyroidism / Hypovitaminosis D1
2CompletedTreatmentDeficiency, Vitamin D / Hypertensive1
2CompletedTreatmentEnd-Stage Renal Disease (ESRD)1
2CompletedTreatmentFalls, Accidental / Parkinson's Disease (PD)1
2CompletedTreatmentGaucher's Disease / Osteopenia1
2CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections1
2CompletedTreatmentInfection, Human Immunodeficiency Virus I1
2CompletedTreatmentLupus / Systemic Lupus Erythematosus (SLE)1
2CompletedTreatmentNon-Alcoholic Steatohepatitis (NASH)1
2CompletedTreatmentPolycystic Ovarian Syndrome / Reproductive Endocrinology1
2CompletedTreatmentBone destruction / Postmenopausal Osteoporosis (PMO)1
2CompletedTreatmentProstate Cancer2
2CompletedTreatmentPulmonary Tuberculosis (TB)1
2CompletedTreatmentType 2 Diabetes Mellitus1
2Enrolling by InvitationBasic SciencePulmonary Disease, Chronic Obstructive1
2Enrolling by InvitationPreventionDiabetes, Diabetes Mellitus Type 1 / Prediabetic State1
2Enrolling by InvitationTreatmentDeficiency, Vitamin D / Diabetes Mellitus (DM) / Hypertensive / Lipid Metabolism Disorders / Obesity, Abdominal1
2Not Yet RecruitingPreventionDeficiency, Vitamin D / Hypertensive1
2Not Yet RecruitingPreventionNeurofibromatosis Type 1 (NF1)1
2Not Yet RecruitingTreatmentDeficiency, Vitamin D1
2Not Yet RecruitingTreatmentOptic Neuritis1
2RecruitingBasic ScienceDeficiency, Vitamin D1
2RecruitingOtherFracture Bone1
2RecruitingPreventionDeficiency, Vitamin D / Peritoneal Dialysis-associated Peritonitis1
2RecruitingPreventionBone destruction / Osteopenia1
2RecruitingTreatmentAsthma Bronchial1
2RecruitingTreatmentAtopic Dermatitis (AD)1
2RecruitingTreatmentBone Metabolism Biomarkers / Bone Mineral Density / Physical Fitness1
2RecruitingTreatmentDepressive State / Diabetes / Quality of Life1
2RecruitingTreatmentDiabetes / Executive Dysfunction1
2RecruitingTreatmentHuman Immunodeficiency Virus (HIV) Infections1
2RecruitingTreatmentHypovitaminosis D1
2RecruitingTreatmentLeukemia Acute Myeloid Leukemia (AML)1
2RecruitingTreatmentProstate Cancer1
2RecruitingTreatmentTuberculosis1
2TerminatedOtherDisseminated Sclerosis1
2TerminatedSupportive CareNeurotoxicity1
2TerminatedTreatmentSystemic Lupus Erythematosus (SLE)1
2Unknown StatusPreventionCancer, Breast1
2Unknown StatusPreventionSickle Cell Disorders1
2Unknown StatusTreatmentAnemia of Chronic Kidney Disease1
2Unknown StatusTreatmentBMI >30 kg/m2 / Bypass, Gastric / Gastric Resection1
2Unknown StatusTreatmentBMI >30 kg/m2 / Deficiency, Vitamin D / Insulin Resistance1
2Unknown StatusTreatmentDeficiency, Vitamin D1
2Unknown StatusTreatmentDeficiency, Vitamin D / Human Immunodeficiency Virus (HIV) Infections1
2Unknown StatusTreatmentHypovitaminosis D / Type 2 Diabetes Mellitus1
2WithdrawnBasic ScienceBMI >30 kg/m21
2WithdrawnTreatmentDeficiency, Vitamin D / Rheumatoid Arthritis1
2WithdrawnTreatmentSchizoaffective Disorders / Schizophrenic Disorders1
2, 3CompletedPreventionAdenoma benign / Colorectal Cancers / Polyps1
2, 3CompletedPreventionImpaired Glucose Tolerance (IGT)1
2, 3CompletedTreatmentCardiovascular Disease (CVD) / Chronic Kidney Disease (CKD) / Mortality1
2, 3CompletedTreatmentDeficiency, Vitamin D / Hypercalcemia / Primary Hyperparathyroidism1
2, 3CompletedTreatmentDisseminated Sclerosis1
2, 3CompletedTreatmentHIV positve / Human Immunodeficiency Virus (HIV) Infections1
2, 3CompletedTreatmentMale Infertility1
2, 3CompletedTreatmentType 2 Diabetes Mellitus1
2, 3Not Yet RecruitingPreventionCritical Illness / Deficiency, Vitamin D1
2, 3RecruitingTreatmentAllergies1
2, 3RecruitingTreatmentCraniocerebral Trauma / Critical Illness / Deficiency, Vitamin D / Intracranial Aneurysms / Intracranial Hemorrhages / Meningitis / Neoplasms, Brain / Seizures / Spinal Cord Injuries (SCI) / Strokes1
2, 3TerminatedTreatmentCancer, Breast / Musculoskeletal Disorders1
2, 3Unknown StatusTreatmentDeficiency, Vitamin D / Heart Failure, Unspecified1
3Active Not RecruitingPreventionImprove Healthy Ageing in Seniors; Prevent Disease at Older Age1
3Active Not RecruitingPreventionType 2 Diabetes Mellitus1
3Active Not RecruitingTreatmentLocally Advanced Breast Cancer and Large Operable Breast Cancer1
3CompletedHealth Services ResearchDeficiency, Vitamin D1
3CompletedPreventionAcute Bronchiolitis / Acute Tracheobronchitis / Upper Respiratory Tract Infections1
3CompletedPreventionDeficiency, Vitamin D2
3CompletedPreventionDeficiency, Vitamin D / Pregnancy1
3CompletedTreatmentAlzheimer's Disease (AD)1
3CompletedTreatmentAnemias1
3CompletedTreatmentAsthma Bronchial2
3CompletedTreatmentBypass, Gastric / Parathyroid Hormone1
3CompletedTreatmentCKd Patients With Stage 3 and 41
3CompletedTreatmentCancer, Breast1
3CompletedTreatmentChronic Hepatitis C Infection1
3CompletedTreatmentChronic Kidney Disease Stage 3 and 41
3CompletedTreatmentChronic Renal Insufficiency / Deficiency, Vitamin D1
3CompletedTreatmentCritical Illness / Deficiency, Vitamin D1
3CompletedTreatmentDeficiency, Vitamin D3
3CompletedTreatmentDeficiency, Vitamin D / Heart Failure, Unspecified1
3CompletedTreatmentDiabetes / Insulin Resistance / Low-intensity Chronic Inflammation1
3CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Tuberculosis, Pulmonary1
3CompletedTreatmentHypovitaminosis D2
3CompletedTreatmentHypovitaminosis D / Polycystic Ovaries Syndrome1
3CompletedTreatmentInfection NOS1
3CompletedTreatmentPlaque Psoriasis1
3CompletedTreatmentTuberculosis, Pulmonary1
3CompletedTreatmentBone destruction1
3Not Yet RecruitingPreventionEnd Organ Damage / Multiple Organ Failure / Sepsis / Severe Sepsis1
3Not Yet RecruitingTreatmentCritical Illness / Deficiency, Vitamin D1
3Not Yet RecruitingTreatmentCritical Illness / Deficiency, Vitamin D / Sarcopenia1
3Not Yet RecruitingTreatmentCrohn's Disease (CD) / Inflammatory Bowel Diseases (IBD) / Ulcerative Colitis (UC)1
3Not Yet RecruitingTreatmentSchizophrenic Disorders1
3RecruitingPreventionCancers / Cardiovascular Disease (CVD) / Fracture Bone1
3RecruitingPreventionDisseminated Sclerosis1
3RecruitingTreatmentAcute Respiratory Distress Syndrome (ARDS) / Critical Illness / Deficiency, Vitamin D1
3RecruitingTreatmentCrohn's Disease (CD)1
3RecruitingTreatmentCutaneous Malignant Melanoma1
3RecruitingTreatmentDeficiency, Vitamin D1
3RecruitingTreatmentDyslipidemias1
3RecruitingTreatmentH. Pylori Infection1
3RecruitingTreatmentHypogonadism / Pre-frail Seniors1
3RecruitingTreatmentMelanoma1
3RecruitingTreatmentOsteopenia1
3RecruitingTreatmentRelapsing Remitting Multiple Sclerosis (RRMS)1
3RecruitingTreatmentUrticarias1
3TerminatedPreventionPolymorphic Light Eruption (PLE)1
3TerminatedTreatmentDeficiency, Vitamin D / Diabetes Mellitus (DM)1
3Unknown StatusNot AvailableAnemias / Low Birth Weight / Neonatal Mortality1
3Unknown StatusPreventionFalls, Accidental / Fracture Bone / Hip Fractures1
3Unknown StatusTreatmentAlzheimer's Disease (AD) / Down Syndrome (DS)1
3Unknown StatusTreatmentChronic Lymphocytic Leukaemia (CLL)1
3Unknown StatusTreatmentDeficiency, Vitamin D / Renal Osteodystrophy / Transplantation, Kidney1
3Unknown StatusTreatmentTuberculosis1
3Unknown StatusTreatment[X]Statin Causing Adverse Effect in Therapeutic Use1
4Active Not RecruitingPreventionAllergies / Wheezing1
4Active Not RecruitingPreventionHypocalcemia1
4Active Not RecruitingTreatmentAsthma Bronchial1
4Active Not RecruitingTreatmentCalcifications, Vascular / Deficiency, Vitamin D / End Stage Renal Failure on Dialysis / Impaired Renal Function1
4CompletedBasic ScienceDeficiency, Vitamin D2
4CompletedBasic SciencePremature Births1
4CompletedPreventionDeficiency, Vitamin D1
4CompletedPreventionDiabetes, Diabetes Mellitus Type 12
4CompletedPreventionHealthy Humans1
4CompletedPreventionImmune Tolerance1
4CompletedPreventionRecurrent Respiratory Tract Infections1
4CompletedTreatmentAnovulatory cycle / Polycystic Ovaries Syndrome1
4CompletedTreatmentBMI >30 kg/m2 / Deficiency, Vitamin D2
4CompletedTreatmentBariatric Surgery Candidate1
4CompletedTreatmentCardiorenal Syndrome / Chronic Allograft Nephropathy (CAN)1
4CompletedTreatmentDeficiency, Vitamin D2
4CompletedTreatmentDeficiency, Vitamin D / Glucose tolerance impaired / Type 2 Diabetes Mellitus1
4CompletedTreatmentDeficiency, Vitamin D / Polycystic Ovaries Syndrome1
4CompletedTreatmentDiabetes Mellitus (DM)1
4CompletedTreatmentEnd Stage Kidney Disease1
4CompletedTreatmentEpilepsies1
4CompletedTreatmentHyperemesis Gravidarum / Morning Sickness / Nausea / Pregnancy / Vomiting1
4CompletedTreatmentBone destruction / Osteopenia1
4CompletedTreatmentPancreatitis, Chronic1
4CompletedTreatmentPneumonia1
4CompletedTreatmentPostmenopausal Osteoporosis (PMO)1
4CompletedTreatmentPregnancy1
4CompletedTreatmentSeasonal Allergic Rhinitis (SAR)1
4Not Yet RecruitingPreventionHepatocellular,Carcinoma / Viral Hepatitis B1
4Not Yet RecruitingTreatmentVitamin D Substitution1
4RecruitingBasic Science25-Hydroxyvitamin D Concentration / Deficiency, Vitamin D1
4RecruitingPreventionBenign Paroxysmal Positional Vertigo (BPPV)1
4RecruitingPreventionEclampsia / Gestational Hypertension / HELLP Syndrome / Superimposed Preeclampsia / Toxemia1
4RecruitingPreventionFood Allergy1
4RecruitingTreatmentBone Diseases, Metabolic / Renal Insufficiency,Chronic / Vascular Stiffness1
4RecruitingTreatmentBronchiectasis1
4RecruitingTreatmentCerebral Vascular Accident (CVA) / Heart Failure Hospitalization / Mortality / Myocardial Infarction (MI)1
4RecruitingTreatmentDeficiency, Vitamin D1
4RecruitingTreatmentDiabetes, Diabetes Mellitus Type 11
4RecruitingTreatmentHuman Immunodeficiency Virus (HIV) Infections1
4TerminatedTreatmentCrohn's Disease (CD) / Deficiency, Vitamin D1
4TerminatedTreatmentHeart Failure, Unspecified1
4TerminatedTreatmentPeripheral Arterial Disease (PAD)1
4Unknown StatusDiagnosticThalassemia Major (TM)1
4Unknown StatusTreatmentAcute Lower Respiratory Tract Infection / Bronchiolitis / Pneumonia1
4Unknown StatusTreatmentBMI >30 kg/m2 / Deficiency, Vitamin D / Hyperparathyroidism, Secondary1
4Unknown StatusTreatmentBMI >30 kg/m2 / Insulin Resistance1
4Unknown StatusTreatmentDisseminated Sclerosis1
4Unknown StatusTreatmentMetabolic Syndromes1
4Unknown StatusTreatmentPersistent Asthma1
4Unknown StatusTreatmentBone destruction1
4WithdrawnTreatmentCrohn's Disease (CD)1
4WithdrawnTreatmentNephritis / Proteinuria / Systemic Lupus Erythematosus (SLE)1
Not AvailableActive Not RecruitingPreventionHypovitaminosis D1
Not AvailableActive Not RecruitingSupportive CarePrimary Hyperparathyroidism1
Not AvailableActive Not RecruitingTreatmentAsthma Bronchial / Deficiency, Vitamin D1
Not AvailableActive Not RecruitingTreatmentDeficiency, Vitamin D1
Not AvailableCompletedNot AvailableDeficiency, Vitamin D1
Not AvailableCompletedNot AvailableDiabetes, Diabetes Mellitus Type 11
Not AvailableCompletedNot AvailableHMG COA Reductase Inhibitor Adverse Reaction1
Not AvailableCompletedNot AvailableHuman Immunodeficiency Virus (HIV) Infections1
Not AvailableCompletedNot AvailableBone destruction1
Not AvailableCompletedOtherType 2 Diabetes Mellitus1
Not AvailableCompletedPreventionBlood Platelet Disorders / Deficiency, Vitamin D1
Not AvailableCompletedPreventionCancer, Breast1
Not AvailableCompletedPreventionDeficiency, Vitamin D1
Not AvailableCompletedPreventionMalignant Melanoma of Skin1
Not AvailableCompletedPreventionNeural Tube Defects (NTDs)1
Not AvailableCompletedPreventionSarcopenia1
Not AvailableCompletedPreventionBone destruction2
Not AvailableCompletedSupportive CareBurn Injuries / Vitamin D1
Not AvailableCompletedSupportive CareDiabetic Neuropathies1
Not AvailableCompletedSupportive CareTuberculosis, Pulmonary1
Not AvailableCompletedTreatmentAngioedema / Hives / Swelling / Urticarias1
Not AvailableCompletedTreatmentArterial Dysfunction / Chronic Kidney Disease (CKD)1
Not AvailableCompletedTreatmentAsthma Bronchial / Deficiency, Vitamin D / Disease Exacerbation1
Not AvailableCompletedTreatmentAtherosclerosis / Leukocyte Activation Disorder / Oxidative Stress1
Not AvailableCompletedTreatmentBipolar Disorder (BD) / Depression, Bipolar1
Not AvailableCompletedTreatmentChronic Kidney Disease (CKD) / Deficiency, Vitamin D1
Not AvailableCompletedTreatmentChronic Kidney Disease (CKD) / Deficiency, Vitamin D / Insulin Resistance1
Not AvailableCompletedTreatmentChronic Kidney Disease (CKD) / End-Stage Renal Disease (ESRD)1
Not AvailableCompletedTreatmentClozapine Resistant Schizophrenia1
Not AvailableCompletedTreatmentCystic Fibrosis (CF)1
Not AvailableCompletedTreatmentBone destruction / Cystic Fibrosis (CF)1
Not AvailableCompletedTreatmentDeficiency of Vitamin D3 / Gingival and Periodontal Disease / Pregnancy1
Not AvailableCompletedTreatmentDeficiency, Vitamin D4
Not AvailableCompletedTreatmentDeficiency, Vitamin D / End-Stage Renal Disease (ESRD)1
Not AvailableCompletedTreatmentDeficiency, Vitamin D / Hypertensive / Pre-Hypertension1
Not AvailableCompletedTreatmentDeficiency, Vitamin D / Renal Failure Chronic Requiring Hemodialysis1
Not AvailableCompletedTreatmentEnd-Stage Renal Disease (ESRD)2
Not AvailableCompletedTreatmentEndometriosis1
Not AvailableCompletedTreatmentHeart Failure, Unspecified1
Not AvailableCompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections1
Not AvailableCompletedTreatmentHyperparathyroidism, Secondary / Renal Insufficiency,Chronic1
Not AvailableCompletedTreatmentIntestinal Malabsorption / Pancreatitis, Chronic1
Not AvailableCompletedTreatmentPolycystic Ovaries Syndrome1
Not AvailableCompletedTreatmentRenal Osteodystrophy / Secondary Hyperparathyroidism in Chronic Kidney Disease Stage 3 and 41
Not AvailableCompletedTreatmentSystemic Lupus Erythematosus (SLE)1
Not AvailableNot Yet RecruitingPreventionTransient Hypercalciuria1
Not AvailableNot Yet RecruitingTreatmentBreast Cancer Metastatic / Metastatic Breast Cancer (MBC)1
Not AvailableNot Yet RecruitingTreatmentSchizophrenic Disorders1
Not AvailableRecruitingTreatmentBMI >30 kg/m21
Not AvailableRecruitingTreatmentCancer, Breast1
Not AvailableRecruitingTreatmentCancer, Ovarian1
Not AvailableRecruitingTreatmentCardiovascular Disease (CVD) / Deficiency, Vitamin D / Hypertensive / Insulin Resistance / Type 2 Diabetes Mellitus1
Not AvailableRecruitingTreatmentNeoplasms, Brain1
Not AvailableRecruitingTreatmentProphylaxis of Contrast-induced nephropathy1
Not AvailableTerminatedNot AvailableUrolithiasis1
Not AvailableTerminatedBasic ScienceCancer, Breast1
Not AvailableTerminatedTreatmentHMG-CoA Reductase Inhibitors-related Myalgias1
Not AvailableUnknown StatusTreatmentChronic Musculoskeletal Pain / Vitamin D Supplementation1
Not AvailableUnknown StatusTreatmentChronic Rhinosinusitis1
Not AvailableUnknown StatusTreatmentDeficiency, Vitamin D / Hepatocellular,Carcinoma1
Not AvailableUnknown StatusTreatmentDiabetic Kidney Disease1
Not AvailableUnknown StatusTreatmentHypercholesterolemia, Familial1
Not AvailableWithdrawnTreatmentHMG COA Reductase Inhibitor Adverse Reaction1
Not AvailableWithdrawnTreatmentInflammatory Bowel Diseases (IBD) / Ulcerative Colitis (UC)1
Not AvailableWithdrawnTreatmentTuberculosis1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Dosage forms
FormRouteStrength
OintmentTopical
Granule, effervescent; kit; tabletOral
CreamTopical
WaferOral
Kit
Solution / dropsOral400 unit
TabletOral10000 unit
LiquidOral
WaferOral100 unit
TabletOral
PowderOral
CapsuleOral2000 unit
CapsuleOral25000 unit
Solution / dropsOral
SolutionOral
CapsuleOral
Tablet, film coatedOral
Injection, solutionIntravenous
CapsuleOral10000 unit
CapsuleOral5000 unit
CapsuleOral50000 unit
Tablet, coatedOral
Capsule, liquid filledOral
Tablet, chewableOral
Tablet, effervescentOral
Capsule, gelatin coatedOral
TabletOral1000 unit
TabletOral400 unit
CapsuleOral100000 unit
Prices
Unit descriptionCostUnit
Cholecalciferol crystals104.3USD g
Vitamin d3 2400 unit/ml liquid0.8USD ml
Vitamin d3 2000 unit spray0.44USD ml
Vitamin d3 3000 unit tablet0.11USD tablet
Vitamin d-3 2000 unit tablet0.07USD tablet
CVS Pharmacy vitamin d 1000 unit tablet0.04USD tablet
Delta d3 400 unit tablet0.04USD each
Vitamin d 1000 unit tablet0.03USD tablet
Pv vitamin d 2000 unit tablet0.02USD tablet
Pv vitamin d 5000 unit tablet0.02USD tablet
Vitamin d 400 unit tablet0.02USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US5994329Yes1999-01-172019-01-17Us

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)84.5 °CPhysProp
water solubilityInsolubleNot Available
logP7.5Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00038 mg/mLALOGPS
logP7.98ALOGPS
logP7.13ChemAxon
logS-6ALOGPS
pKa (Strongest Acidic)18.38ChemAxon
pKa (Strongest Basic)-1.3ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count1ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area20.23 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity123.22 m3·mol-1ChemAxon
Polarizability49.6 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+1.0
Blood Brain Barrier+0.959
Caco-2 permeable+0.8342
P-glycoprotein substrateSubstrate0.6706
P-glycoprotein inhibitor IInhibitor0.7603
P-glycoprotein inhibitor IINon-inhibitor0.5346
Renal organic cation transporterNon-inhibitor0.7818
CYP450 2C9 substrateNon-substrate0.8384
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateSubstrate0.7302
CYP450 1A2 substrateNon-inhibitor0.9256
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorNon-inhibitor0.9551
CYP450 2C19 inhibitorNon-inhibitor0.9026
CYP450 3A4 inhibitorNon-inhibitor0.7881
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.7093
Ames testNon AMES toxic0.9132
CarcinogenicityNon-carcinogens0.921
BiodegradationNot ready biodegradable0.9878
Rat acute toxicity3.9310 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.773
hERG inhibition (predictor II)Non-inhibitor0.7589
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Download (11.1 KB)
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as vitamin d and derivatives. These are compounds containing a secosteroid backbone, usually secoergostane or secocholestane.
Kingdom
Organic compounds
Super Class
Lipids and lipid-like molecules
Class
Steroids and steroid derivatives
Sub Class
Vitamin D and derivatives
Direct Parent
Vitamin D and derivatives
Alternative Parents
Triterpenoids / Secondary alcohols / Cyclic alcohols and derivatives / Hydrocarbon derivatives
Substituents
Triterpenoid / Cyclic alcohol / Secondary alcohol / Organic oxygen compound / Hydrocarbon derivative / Organooxygen compound / Alcohol / Aliphatic homopolycyclic compound
Molecular Framework
Aliphatic homopolycyclic compounds
External Descriptors
secondary alcohol, steroid hormone, seco-cholestane, hydroxy seco-steroid, D3 vitamins (CHEBI:28940) / Vitamin D3 and derivatives, Fat-soluble vitamins (C05443) / Vitamin D3 and derivatives (LMST03020000)

Targets

Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Agonist
General Function
Zinc ion binding
Specific Function
Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Recruited to promoters via its interaction with BAZ1B...
Gene Name
VDR
Uniprot ID
P11473
Uniprot Name
Vitamin D3 receptor
Molecular Weight
48288.64 Da
References
  1. Reinhart GA: Vitamin D analogs: novel therapeutic agents for cardiovascular disease? Curr Opin Investig Drugs. 2004 Sep;5(9):947-51. [PubMed:15503649]
  2. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352]
  3. Fujishima T, Tsuji G, Tanaka C, Harayama H: Novel vitamin D receptor ligands having a carboxyl group as an anchor to arginine 274 in the ligand-binding domain. J Steroid Biochem Mol Biol. 2010 Jul;121(1-2):60-2. doi: 10.1016/j.jsbmb.2010.04.020. Epub 2010 May 6. [PubMed:20435140]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3).
Gene Name
CYP2R1
Uniprot ID
Q6VVX0
Uniprot Name
Vitamin D 25-hydroxylase
Molecular Weight
57358.82 Da
References
  1. Flanagan JN, Young MV, Persons KS, Wang L, Mathieu JS, Whitlatch LW, Holick MF, Chen TC: Vitamin D metabolism in human prostate cells: implications for prostate cancer chemoprevention by vitamin D. Anticancer Res. 2006 Jul-Aug;26(4A):2567-72. [PubMed:16886665]
  2. Segura-Aguilar J: Peroxidase activity of liver microsomal vitamin D 25-hydroxylase and cytochrome P450 1A2 catalyzes 25-hydroxylation of vitamin D3 and oxidation of dopamine to aminochrome. Biochem Mol Med. 1996 Jun;58(1):122-9. [PubMed:8809353]
  3. Schuster I: Cytochromes P450 are essential players in the vitamin D signaling system. Biochim Biophys Acta. 2011 Jan;1814(1):186-99. doi: 10.1016/j.bbapap.2010.06.022. Epub 2010 Jul 7. [PubMed:20619365]
  4. Ohyama Y, Yamasaki T: Eight cytochrome P450s catalyze vitamin D metabolism. Front Biosci. 2004 Sep 1;9:3007-18. [PubMed:15353333]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Catalyzes the first step in the oxidation of the side chain of sterol intermediates; the 27-hydroxylation of 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol. Has also a vitamin D3-25-hydroxylase a...
Gene Name
CYP27A1
Uniprot ID
Q02318
Uniprot Name
Sterol 26-hydroxylase, mitochondrial
Molecular Weight
60234.28 Da
References
  1. Lehmann B, Tiebel O, Meurer M: Expression of vitamin D3 25-hydroxylase (CYP27) mRNA after induction by vitamin D3 or UVB radiation in keratinocytes of human skin equivalents--a preliminary study. Arch Dermatol Res. 1999 Sep;291(9):507-10. [PubMed:10541881]
  2. Sawada N, Sakaki T, Yoneda S, Kusudo T, Shinkyo R, Ohta M, Inouye K: Conversion of vitamin D3 to 1alpha,25-dihydroxyvitamin D3 by Streptomyces griseolus cytochrome P450SU-1. Biochem Biophys Res Commun. 2004 Jul 16;320(1):156-64. [PubMed:15207715]
  3. Uchida E, Kagawa N, Sakaki T, Urushino N, Sawada N, Kamakura M, Ohta M, Kato S, Inouye K: Purification and characterization of mouse CYP27B1 overproduced by an Escherichia coli system coexpressing molecular chaperonins GroEL/ES. Biochem Biophys Res Commun. 2004 Oct 15;323(2):505-11. [PubMed:15369780]
  4. Sakaki T, Kagawa N, Yamamoto K, Inouye K: Metabolism of vitamin D3 by cytochromes P450. Front Biosci. 2005 Jan 1;10:119-34. Print 2005 Jan 1. [PubMed:15574355]
  5. Tokar EJ, Webber MM: Cholecalciferol (vitamin D3) inhibits growth and invasion by up-regulating nuclear receptors and 25-hydroxylase (CYP27A1) in human prostate cancer cells. Clin Exp Metastasis. 2005;22(3):275-84. [PubMed:16158255]
  6. Schuster I: Cytochromes P450 are essential players in the vitamin D signaling system. Biochim Biophys Acta. 2011 Jan;1814(1):186-99. doi: 10.1016/j.bbapap.2010.06.022. Epub 2010 Jul 7. [PubMed:20619365]
  7. Ohyama Y, Yamasaki T: Eight cytochrome P450s catalyze vitamin D metabolism. Front Biosci. 2004 Sep 1;9:3007-18. [PubMed:15353333]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Steroid hydroxylase activity
Specific Function
This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation to all four regioisomeric cis-epoxyeicosatrienoic acids. One of the predominant enzymes responsible f...
Gene Name
CYP2J2
Uniprot ID
P51589
Uniprot Name
Cytochrome P450 2J2
Molecular Weight
57610.165 Da
References
  1. Aiba I, Yamasaki T, Shinki T, Izumi S, Yamamoto K, Yamada S, Terato H, Ide H, Ohyama Y: Characterization of rat and human CYP2J enzymes as Vitamin D 25-hydroxylases. Steroids. 2006 Oct;71(10):849-56. Epub 2006 Jul 13. [PubMed:16842832]
  2. Schuster I: Cytochromes P450 are essential players in the vitamin D signaling system. Biochim Biophys Acta. 2011 Jan;1814(1):186-99. doi: 10.1016/j.bbapap.2010.06.022. Epub 2010 Jul 7. [PubMed:20619365]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Schuster I: Cytochromes P450 are essential players in the vitamin D signaling system. Biochim Biophys Acta. 2011 Jan;1814(1):186-99. doi: 10.1016/j.bbapap.2010.06.022. Epub 2010 Jul 7. [PubMed:20619365]
  2. Ohyama Y, Yamasaki T: Eight cytochrome P450s catalyze vitamin D metabolism. Front Biosci. 2004 Sep 1;9:3007-18. [PubMed:15353333]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, nad(p)h as one donor, and incorporation of one atom of oxygen
Specific Function
Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.
Gene Name
CYP11A1
Uniprot ID
P05108
Uniprot Name
Cholesterol side-chain cleavage enzyme, mitochondrial
Molecular Weight
60101.87 Da
References
  1. Tuckey RC, Janjetovic Z, Li W, Nguyen MN, Zmijewski MA, Zjawiony J, Slominski A: Metabolism of 1alpha-hydroxyvitamin D3 by cytochrome P450scc to biologically active 1alpha,20-dihydroxyvitamin D3. J Steroid Biochem Mol Biol. 2008 Dec;112(4-5):213-9. doi: 10.1016/j.jsbmb.2008.10.005. Epub 2008 Oct 21. [PubMed:19000766]
  2. Tuckey RC, Nguyen MN, Slominski A: Kinetics of vitamin D3 metabolism by cytochrome P450scc (CYP11A1) in phospholipid vesicles and cyclodextrin. Int J Biochem Cell Biol. 2008;40(11):2619-26. doi: 10.1016/j.biocel.2008.05.006. Epub 2008 May 20. [PubMed:18573681]
  3. Guryev O, Carvalho RA, Usanov S, Gilep A, Estabrook RW: A pathway for the metabolism of vitamin D3: unique hydroxylated metabolites formed during catalysis with cytochrome P450scc (CYP11A1). Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14754-9. Epub 2003 Dec 1. [PubMed:14657394]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Vitamin d 24-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP1A1
Uniprot ID
P04798
Uniprot Name
Cytochrome P450 1A1
Molecular Weight
58164.815 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2B6
Uniprot ID
P20813
Uniprot Name
Cytochrome P450 2B6
Molecular Weight
56277.81 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Steroid hydroxylase activity
Specific Function
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and im...
Gene Name
CYP2C19
Uniprot ID
P33261
Uniprot Name
Cytochrome P450 2C19
Molecular Weight
55930.545 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2C8
Uniprot ID
P10632
Uniprot Name
Cytochrome P450 2C8
Molecular Weight
55824.275 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2C9
Uniprot ID
P11712
Uniprot Name
Cytochrome P450 2C9
Molecular Weight
55627.365 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Steroid hydroxylase activity
Specific Function
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic...
Gene Name
CYP2D6
Uniprot ID
P10635
Uniprot Name
Cytochrome P450 2D6
Molecular Weight
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]

Carriers

Kind
Protein
Organism
Human
Pharmacological action
No
General Function
Vitamin transporter activity
Specific Function
Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.
Gene Name
GC
Uniprot ID
P02774
Uniprot Name
Vitamin D-binding protein
Molecular Weight
52963.025 Da
References
  1. Nykjaer A, Dragun D, Walther D, Vorum H, Jacobsen C, Herz J, Melsen F, Christensen EI, Willnow TE: An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3. Cell. 1999 Feb 19;96(4):507-15. [PubMed:10052453]
  2. Verboven C, Rabijns A, De Maeyer M, Van Baelen H, Bouillon R, De Ranter C: A structural basis for the unique binding features of the human vitamin D-binding protein. Nat Struct Biol. 2002 Feb;9(2):131-6. [PubMed:11799400]
  3. Houghton LA, Vieth R: The case against ergocalciferol (vitamin D2) as a vitamin supplement. Am J Clin Nutr. 2006 Oct;84(4):694-7. [PubMed:17023693]
  4. Yamamoto N, Naraparaju VR: Vitamin D3-binding protein as a precursor for macrophage activating factor in the inflammation-primed macrophage activation cascade in rats. Cell Immunol. 1996 Jun 15;170(2):161-7. [PubMed:8660814]
  5. Yamamoto N, Naraparaju VR: Role of vitamin D3-binding protein in activation of mouse macrophages. J Immunol. 1996 Aug 15;157(4):1744-9. [PubMed:8759764]

Drug created on June 13, 2005 07:24 / Updated on October 21, 2017 19:20