Identification
NameCholecalciferol
Accession NumberDB00169  (NUTR00008, APRD00506)
TypeSmall Molecule
GroupsApproved, Nutraceutical
Description

Derivative of 7-dehydroxycholesterol formed by ultraviolet rays breaking of the C9-C10 bond. It differs from ergocalciferol in having a single bond between C22 and C23 and lacking a methyl group at C24.

Structure
Thumb
Synonyms
(+)-vitamin D3
(1S,3Z)-3-[(2e)-2-[(1R,3AR,7as)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexan-1-ol
(3β,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol
(5Z,7E)-(3S)-9,10-secocholesta-5,7,10(19)-trien-3-ol
Activated 7-dehydrocholesterol
Calciol
CC
Colecalciferol
colecalciferolum
Oleovitamin D3
Vitamin D-3
Vitamin D3
External IDs NSC-375571
Product Ingredients Not Available
Product Images
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Cataplex D Tab 400unitTablet400 unitOralStandard Process Inc.Not applicableNot applicableCanada
D-tabs 10000unitTablet10000 unitOralLaboratoire Riva Inc1992-12-31Not applicableCanada
Euro D 10 000Capsule10000 unitOralEuro Pharm International Canada IncNot applicableNot applicableCanada
Euro D 10 000Capsule10000 unitOralSandoz Canada Incorporated2005-04-06Not applicableCanada
Formula 3200 Waf 100unitWafer100 unitOralStandard Process Inc.Not applicableNot applicableCanada
Jamp-vitamin DCapsule10000 unitOralJamp Pharma Corporation2015-11-20Not applicableCanada
Jamp-vitamin DCapsule50000 unitOralJamp Pharma Corporation2016-06-23Not applicableCanada
Jamp-vitamin DCapsule25000 unitOralJamp Pharma CorporationNot applicableNot applicableCanada
Jamp-vitamin DCapsule2000 unitOralJamp Pharma CorporationNot applicableNot applicableCanada
Jamp-vitamin DCapsule5000 unitOralJamp Pharma CorporationNot applicableNot applicableCanada
Pharma-D 10000 IuCapsule10000 unitOralPharmascience Inc2011-08-29Not applicableCanada
Pharma-D 5000 IuCapsule5000 unitOralPharmascience IncNot applicableNot applicableCanada
Pharma-D 50000 IuCapsule50000 unitOralPharmascience Inc2011-08-09Not applicableCanada
Riva-DTablet10000 unitOralLaboratoire Riva IncNot applicableNot applicableCanada
Vitamin D3-softgel CapsulesCapsule100000 unitOralOrimed Pharma CorporationNot applicableNot applicableCanada
Vitamin D3-softgel Capsules 10000 IuCapsule10000 unitOralOrimed Pharma Corporation2015-10-20Not applicableCanada
Vitamin D3-softgel Capsules 2000 IuCapsule2000 unitOralOrimed Pharma Corporation2015-07-31Not applicableCanada
Vitamin D3-softgel Capsules 25000 IuCapsule25000 unitOralOrimed Pharma Corporation2015-07-31Not applicableCanada
Vitamin D3-softgel Capsules 5000 IuCapsule5000 unitOralOrimed Pharma Corporation2015-10-20Not applicableCanada
Vitamin D3-softgel Capsules 50000 IuCapsule50000 unitOralOrimed Pharma Corporation2015-10-20Not applicableCanada
Approved Generic Prescription ProductsNot Available
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
D Vi Sol Infants Drops 400unit/0.6mlSolution / drops400 unitOralMead Johnson Nutritionals1985-12-311998-09-28Canada
Vitamin D 1000iuTablet1000 unitOralWn Pharmaceuticals Ltd.1999-07-082007-08-07Canada
Vitamin D 400 IuTablet400 unitOralWn Pharmaceuticals Ltd.2002-03-132007-08-07Canada
Vitamin D 400 Iu TabletsTablet400 unitOralSwiss Herbal Remedies Ltd.1996-12-112009-08-04Canada
Vitamin D-dry 400 I.U.Tablet400 unitOralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
Unapproved/Other Products Not Available
International Brands
NameCompany
Delta-DNot Available
Micro-DNot Available
Optimal-DRV Nutritional, LLC
VigantolNot Available
Brand mixtures
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
A + D OintmentOintmentTopicalNational Care Products Ltd.1993-12-312002-10-10Canada
A.R.T.H. Away FormulaCapsuleOralAbundance Marketing Ltd.1999-02-012006-06-16Canada
Acti-cal/mag 2:1 + Zinc and D CapletTabletOralActi Form Ltd.1991-12-312005-03-21Canada
Actical Plus Calcium-magnesium-vitamin D3-silicon ChewableTabletOralUsana Health Sciences, Inc.1999-09-302004-07-27Canada
Active Calcium Plus Magnesium, Vitamin D and SiliconTabletOralUsana Health Sciences, Inc.2002-07-082007-07-18Canada
Active FETabletOralGm Pharmaceuticals2013-11-11Not applicableUs
Actonel Sachet KitGranule, effervescent; Kit; TabletOralWarner ChilcottNot applicableNot applicableCanada
AdrovanceTabletOralMerck Sharp & Dohme Limited2007-01-04Not applicableEu
Adult Infuvite Multiple VitaminsInjection, solutionIntravenousSandoz2005-05-18Not applicableUs
Alendronate-cholecalciferolTabletOralFrosst A Division Of Merck Canada IncNot applicableNot applicableCanada
Animi-3CapsuleOralPbm Pharmaceuticals Inc.2011-06-01Not applicableUs
Animi-3 with Vitamin DCapsuleOralPbm Pharmaceuticals Inc.2011-06-01Not applicableUs
Antiseptic Skin CreamCreamTopicalArjohuntleigh1993-12-311997-11-12Canada
ApcalTabletOralA P J Laboratories Limited2013-03-01Not applicableUs
Apo-alendronate/vitamin D3TabletOralApotex Corporation2016-07-21Not applicableCanada
Avon Nutrivance Soft Calcium Chews With Vitamin DTablet, chewableOralAvon Products, Inc.2004-01-052006-07-14Canada
Beta Carotene Provitamin A With DTabletOralGahler Enterprises Ltd.1984-12-312000-08-01Canada
C-Nate DHACapsule, gelatin coatedOralCenturion Labs2013-01-01Not applicableUs
C.H.V. FormulaCapsuleOralNihon Kenko Zoushin Kenkyukai Canada Inc., Subsidery Of Nikken Usa Inc.1999-09-252005-07-15Canada
Cal-mag Citrate Zinc & Vitamin D TabletsTabletOralSwiss Herbal Remedies Ltd.Not applicableNot applicableCanada
Cal-mag Complete With Zinc, C and DTabletOralQuest Vitamins A Div Of Purity Life Health Products1992-12-312009-07-14Canada
Cal-mag With Zinc & Vitamin DTabletOralHealth Wise Nutrition Inc.2000-06-092002-07-18Canada
Cal/mag 1:1 With Zinc and Vitamin D - TabletTabletOralHealth Wise Nutrition Inc.1997-08-152002-07-18Canada
Calci-yum Plus Magnesium + D3TabletOralNu Life Nutrition Ltd.1987-12-312000-05-23Canada
Calcium & Magnesium Citrate Plus D With Manganese, Potassium & ZincTabletOralNatural Factors Nutritional Products Ltd.1998-12-142008-07-17Canada
Calcium & Magnesium With Potassium, Zinc, Manganese & Vitamin DTabletOralWn Pharmaceuticals Ltd.2000-08-302005-08-15Canada
Calcium & Vitamin DCapsuleOralQuantofill Inc.Not applicableNot applicableCanada
Calcium 250 Mg With Vitamin DTabletOralGfr Pharma Ltd.2002-10-102008-07-17Canada
Calcium 600 + DTabletOralLaboratoire Riva Inc2001-01-152008-08-11Canada
Calcium 600mg + Vit D3 125unit TabTabletOralPharmetics (2011) Inc.1994-12-312009-07-30Canada
Calcium and Magnesium 1:1 Plus TabletsTabletOralAlbi Naturals1998-02-202009-07-15Canada
Calcium and Magnesium Citrate and Vitamin D 250mg/125mg/200iuTabletOralWn Pharmaceuticals Ltd.2001-11-232002-05-15Canada
Calcium and Magnesium With Vitamin DTabletOralVita Health Products Inc1998-09-152002-07-31Canada
Calcium Citrate and Vitamin D 200mg/160iuCapsuleOralWn Pharmaceuticals Ltd.2001-11-302002-07-07Canada
Calcium Citrate With Vitamin DTabletOralWn Pharmaceuticals Ltd.2001-11-232007-08-07Canada
Calcium Complex High GradeCapsuleOralNew Spirit Naturals, Inc.Not applicableNot applicableCanada
Calcium Et Magnesium Plus Vitamin DTabletOralLaboratoire Lalco Inc.Not applicableNot applicableCanada
Calcium Folic Acid Plus D ChewableWaferOralAcella Pharmaceuticals, LLC2010-03-23Not applicableUs
Calcium Supplement TabTabletOralHillestad Pharmaceuticals Usa1997-09-042009-09-22Canada
Calcium With Mg Zn Mn Cu CR Si and Vit. C & DTabletOralJamieson Laboratories Ltd1993-12-312001-09-14Canada
Calcium With Vitamin D 200 Mg/160 IuCapsuleOralWn Pharmaceuticals Ltd.2002-07-072007-08-07Canada
Calcium-magnesium With K & Zn and Vitamin D3CapsuleOralHolista Health (Canada) Inc.1997-08-152002-08-06Canada
Calcium/magnesium/vitamin D - CapsuleCapsuleOralHolista Health (Canada) Inc.1996-12-312002-08-06Canada
Calma-DTabletOralWn Pharmaceuticals Ltd.1999-01-212009-09-28Canada
CalplusTabletOralLifestyles Canada Corporation1998-08-072000-07-16Canada
Caltrate 600 Plus D - TabletTabletOralWhitehall Robins Inc.1985-12-312001-08-07Canada
Central-vite 18 EssentialTabletOralVita Health Products Inc1998-04-242002-07-31Canada
Chela Calmag-100 Plus Zinc D3TabletOralNu Life Nutrition Ltd.1987-12-312000-03-03Canada
Chela Calmag-300 Plus Zinc D3TabletOralNu Life Nutrition Ltd.1987-12-312000-03-03Canada
Chewable MultivitaminsTabletOralWn Pharmaceuticals Ltd.2002-05-312008-07-17Canada
Chewable Multivitamins Plus IronTabletOralWn Pharmaceuticals Ltd.2002-05-312007-08-07Canada
Children Choice Multivit Chewable TabTabletOralSwiss Herbal Remedies Ltd.1990-12-312009-08-04Canada
Children Choice Multivitamin W Iron Chew TabTabletOralSwiss Herbal Remedies Ltd.1991-12-312009-08-04Canada
Children Vitamin DropsLiquidOralWampole Brands, A Division Of Pangeo Pharma (Canada) Inc.1998-08-122002-07-29Canada
Children's Chewable Multi-vitaminTabletOralWn Pharmaceuticals Ltd.2000-03-012007-08-07Canada
Children's Chewable Multi-vitamin Complete With MineralsTabletOralWn Pharmaceuticals Ltd.2000-03-012001-07-18Canada
Children's Chewable Multiple Vit.plus IronTabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1997-10-102002-07-31Canada
Children's Chewable Multiple Vitamins - TabTabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1997-10-102002-07-31Canada
Children's Vitamins ChewableTabletOralVita Health Products Inc1990-12-312002-07-31Canada
Children's Vitamins W Iron ChewableTabletOralVita Health Products Inc1990-12-312002-07-31Canada
Childrens Chewable Vitamin TabTabletOralPharmetics (2011) Inc.1993-12-312006-07-27Canada
Childrens Chewable VitaminsTabletOralGarden State Nutritionals1998-09-252000-06-07Canada
CiferexCapsuleOralAdler Stern Pharmaceuticals, Llc2014-11-112017-09-13Us
CifrazolCapsuleOralSterling Knight Pharmaceuticals, Llc2017-01-10Not applicableUs
CitraNatal B-CalmKitMission Pharmacal2010-02-10Not applicableUs
CitraNatal Harmony 3.0Capsule, gelatin coatedOralMission Pharmacal2014-03-21Not applicableUs
Cod Liver Oil Mint FlavLiquidOralNu Life Nutrition Ltd.1987-12-311999-05-10Canada
Cod Liver Oil Oleovitamin A & D Caps 20minTabletOralNutricorp International1993-12-312000-09-26Canada
Complete Multivitamins and Minerals for ChildrenTabletOralQuest Vitamins A Div Of Purity Life Health Products2001-01-312004-06-29Canada
Coral Calcium Plus Vitamin D 210mg/100iuCapsuleOralWn Pharmaceuticals Ltd.2004-12-012009-09-28Canada
Derma-forceCapsuleOralPrairie Naturals1997-04-012006-09-20Canada
Dry Super Vitamin A Plus D - CapCapsuleOralGeneral Nutrition Canada Inc.1997-04-182005-08-05Canada
DuracholCapsuleOralSterling Knight Pharmaceuticals, Llc2014-11-16Not applicableUs
Efferlife Calcium 500mg + Vitamin D3 440 Iu + Vitamin C 125mgTablet, effervescentOralNaturale Science Inc.2001-10-012006-10-10Canada
Efferlife Multivitamins and MineralsTablet, effervescentOralNaturale Science Inc.2001-10-012006-10-10Canada
Enviroflex - TabTabletOralEnviro Tech International Canada1997-09-151999-07-26Canada
EscaviteTablet, chewableOralGm Pharmaceuticals2012-02-01Not applicableUs
Extra P.N. Vitamin-mineral Drink MixPowderOralChanges InternationalNot applicableNot applicableCanada
Extra-Virt Plus DHACapsule, gelatin coatedOralVirtus Pharmaceuticals2012-12-28Not applicableUs
FlorivaLiquidOralBon Geo Pharmaceuticals, Inc.2014-10-15Not applicableUs
Floriva PlusSolution / dropsOralBon Geo Pharmaceuticals, Inc.2015-12-28Not applicableUs
Folcal DHACapsule, gelatin coatedOralMidlothian Laboratories2010-12-01Not applicableUs
Folcaps Care OneCapsule, gelatin coatedOralMidlothian Laboratories2009-05-01Not applicableUs
Folcaps Omega-3Capsule, gelatin coatedOralMidlothian Laboratories2011-01-03Not applicableUs
Folet OneCapsule, liquid filledOralPronova Corporation2014-06-01Not applicableUs
Folivane-PRx DHACapsuleOralTrigen Laboratories, Inc.2010-01-01Not applicableUs
Foltabs PrenatalTabletOralMidlothian Laboratories2009-01-01Not applicableUs
For Kids Only Chewable Multivit. Plus IronTabletOralKsl Pharmaceuticals1996-12-312002-07-31Canada
For Kids Only Chewable Multivitamins - TabTabletOralKsl Pharmaceuticals1996-12-312002-07-31Canada
Formula O-care Vitamin and Mineral SupplementTabletOralFor Mor International Inc.2000-03-252002-06-25Canada
Formula OsgTabletOralSeroyal International Inc.1994-12-312000-08-08Canada
Fortamines 10 CapsulesCapsuleOralRougier Pharma Division Of Ratiopharm Inc1974-12-311999-09-27Canada
Fortamines-10 ComprimesTabletOralRougier Pharma Division Of Ratiopharm Inc1979-12-312003-09-22Canada
Forty Plus Vitamin SupplementTabletOralGarden State Nutritionals1998-10-162000-06-07Canada
Fosamax Plus DTabletOralMerck Sharp & Dohme Limited2005-04-07Not applicableUs
FosavanceTabletOralMerck Ltd.2006-03-13Not applicableCanada
G.A.S. ComplexTabletOralAbundance Marketing Ltd.2000-12-062004-06-30Canada
Garfield Chewable Multivits Plus Iron TabTabletOralWhitehall Robins Inc.1993-12-312000-07-26Canada
Gestamine ComprimesTabletOralLab Nadeau LtÉe, Division Of Technilab Inc.1957-12-311999-09-28Canada
Gesticare DHAKitJazz Pharmaceuticals Commercial Corp.2008-10-01Not applicableUs
healthy mamaBE WELL ROUNDED BE WELL ROUNDEDTablet, film coatedOralMATERNAL SCIENCE, LLC2013-07-09Not applicableUs
HemeNatal OBTabletOralWh Nutritionals, Llc2012-03-08Not applicableUs
Hormodausse Plus Calc Et D TabTabletOralLaboratoires Charton Laboratories1988-12-311999-01-16Canada
Hvp Chelated Cal/mag With Zinc and Vitamins C and DTabletOralDarwen Holdings Ltd.Not applicableNot applicableCanada
Inatal AdvanceTablet, coatedOralNnodum Pharmaceuticals2005-06-10Not applicableUs
INATAL UltraTablet, coatedOralNnodum Pharmaceuticals2005-06-20Not applicableUs
Infant Multivitamin DropsSolution / dropsOralGeneral Nutrition Canada Inc.2002-10-202005-08-05Canada
Infuvite Adult Multiple VitaminsInjection, solutionIntravenousSandoz2005-05-18Not applicableUs
IpricalTabletOralPep Products Inc.1999-03-142003-01-13Canada
Iron Polysaccharides Folic Acid DHATablet, film coatedOralVirtus Pharmaceuticals2013-12-202017-08-11Us
Isotonix Calcium Plus FormulaPowderOralMarket America1998-12-172001-06-28Canada
Kid's Choice Children's Chewable Vitamins - TabTabletOralVita Health Products Inc1998-04-162002-07-31Canada
Kids Stuff TabletsTabletOralVita Health Products Inc1998-04-202002-07-31Canada
Kids Stuff With Iron TabletsTabletOralVita Health Products Inc1998-04-202002-07-31Canada
Kimchi Vitamin chewable multivitaminTablet, chewableOralTobico2010-03-18Not applicableUs
L.I.P. ComplexTabletOralAbundance Marketing Ltd.2000-12-062004-06-30Canada
Liqui Cal-DLiquidOralTwin Laboratories Inc.1995-12-312002-09-11Canada
Liquid Cal/mag Plus DLiquidOralGahler Enterprises Ltd.1991-12-312002-07-17Canada
Liquid Calcium and Magnesium With Vit.dLiquidOralRheingold Food International Ltd.1994-12-312007-07-26Canada
MagnacalCapsuleOralHolista Health (Canada) Inc.1996-11-012002-08-06Canada
Menocal TabTabletOralLes Aliments Nutri Source Inc.1994-12-312009-08-05Canada
Mid-life Magnacal 2CapsuleOralHolista Health (Canada) Inc.1999-08-192002-08-06Canada
Milk Calcium With Vitamins C, D, and PhosphorousTabletOralQuest Vitamins A Div Of Purity Life Health Products2000-10-012006-07-25Canada
Mor-vites TabTabletOralPharmetics (2011) Inc.1992-12-312006-07-27Canada
Multi - N.T.O.x Formula - TabTabletOralAbundance Naturally LtdNot applicableNot applicableCanada
Multi Vitamin - MineralTabletOralEnrich International1999-11-112001-09-28Canada
Multi Vitamin & MineralsTabletOralWn Pharmaceuticals Ltd.2002-01-042008-07-17Canada
Multi Vitamin and FluorideSolution / dropsOralLibertas Pharma, Inc.2011-05-21Not applicableUs
Multi Vitamin Drops with FluorideSolution / dropsOralSeton Pharmaceuticals2014-04-18Not applicableUs
Multi Vitamin Drops with Fluoride and IronSolution / dropsOralSeton Pharmaceuticals2014-04-18Not applicableUs
Multi Vitamin Drops with Fluoride with IronLiquidOralStratus Pharmaceuticals2014-09-01Not applicableUs
Multi Vitamin Plus IronTabletOralWn Pharmaceuticals Ltd.2002-03-132009-09-28Canada
Multi Vitamin with FluorideTablet, chewableOralQualitest2009-10-092016-10-13Us
Multi Vitamin, Iron and FluorideSolution / dropsOralMayne Pharma2011-05-212019-10-31Us
Multi Vitamins & MineralsTabletOralWn Pharmaceuticals Ltd.2000-01-122001-04-12Canada
Multi-Vit with FluorideSolutionOralA S Medication Solutions1997-04-182017-06-20Us
Multi-Vit with Fluoride and IronSolutionOralQualitest1998-01-07Not applicableUs
Multi-vitamin Dietary SupplementTabletOralGarden State Nutritionals1998-09-222000-06-07Canada
Multi-Vitamin Drops with Fluoride and IronLiquidOralMethod Pharmaceuticals2017-02-24Not applicableUs
Multi-Vitamin FluorideLiquidOralStratus Pharmaceuticals2014-09-01Not applicableUs
Multi-Vitamin Fluoride and Iron DropsSolutionOralBoca Pharmacal, Inc.2011-04-202015-12-29Us
Multi-Vitamin Fluoride DropsSolutionOralH.J. Harkins Company2011-05-04Not applicableUs
Multi-Vitamin With FluorideTablet, chewableOralLibertas Pharma, Inc.2011-05-21Not applicableUs
Multi-vitaminsTabletOralWn Pharmaceuticals Ltd.1999-12-222008-07-17Canada
Multi-vitamins With MineralsTabletOralWn Pharmaceuticals Ltd.2001-04-122009-09-28Canada
Multiple VitaminsTabletOralGfr Pharma Ltd.2002-10-102007-07-20Canada
Multiple Vitamins & Minerals TabletsTabletOralPharmetics (2011) Inc.2002-12-182006-07-27Canada
MultivitaminTabletOralLaboratoires Confab IncNot applicableNot applicableCanada
Multivitamin Drops with FluorideSolution / dropsOralSancilio & Company, Inc.2017-04-10Not applicableUs
MultiVitamin Drops with Fluoride and IronLiquidOralSancilio & Company, Inc.2017-08-24Not applicableUs
Multivitamin with FluorideTablet, chewableOralPure Tek Corporation2011-06-01Not applicableUs
Multivitamines Et Mineraux Junior RegulierTabletOralLaboratoire Riva Inc1996-10-082008-07-30Canada
Multivitamines Et Mineraux Reguliers / Regular Multivitamins and MineralsTabletOralVita Health Products Inc1998-10-062004-07-26Canada
Multivitamines Plus Fer Pour Enfants (chewable Tablets)TabletOralLaboratoire Lalco Inc.1998-07-032002-09-05Canada
Multivitamines Pour Enfants (chewable Tablets)TabletOralLaboratoire Lalco Inc.1998-07-032002-09-05Canada
Multivitamins and Minerals - CompleteTabletOralVita Health Products Inc2000-02-012006-07-31Canada
Multivitamins and Multiminerals Formula Regular TabletTabletOralPharmetics (2011) Inc.2001-11-222009-07-30Canada
Multivitamins for ChildrenTabletOralQuest Vitamins A Div Of Purity Life Health Products2001-01-312004-06-29Canada
MvcTablet, chewableOralSancilio & Company Inc.2009-12-20Not applicableUs
N.E.U. ComplexTabletOralAbundance Marketing Ltd.2000-12-042004-06-30Canada
Nata KompleteTabletOralWh Nutritionals, Llc2011-06-252016-12-06Us
NataFortTabletOralMission Pharmacal2011-08-25Not applicableUs
NataviteTabletOralSchein Pharmaceutical Canada Inc.1997-07-292004-07-26Canada
Neo-vites & Minerals TabTabletOralNeolab Inc1987-12-311997-08-12Canada
Nestabs ONECapsule, gelatin coatedOralWomens Choice Pharmaceuticals, Llc2017-07-20Not applicableUs
Nexa PlusCapsuleOralUpsher Smith Laboratories2012-08-01Not applicableUs
Nexa Select Rx Prenatal Vitamin with Plant-Based DHACapsuleOralUpsher Smith Laboratories2012-12-17Not applicableUs
NuFeraTabletOralCarwin Associates, Inc2015-12-16Not applicableUs
Nutri-chem Calcium Magnesium With D and ZincTabletOralNutri Chem Pharmacy Ltd2001-08-272009-08-19Canada
Nutrifer Plus TabletsTabletOralWyeth Ayerst Canada Inc.1994-12-311999-09-23Canada
Nutrilite Double XTabletOralNutrilite, A Division Of Access Business Group, Llc2002-12-152008-06-24Canada
O Calcium 500mg Plus D TabTabletOralVita Health Products Inc1991-12-312006-07-31Canada
O-Cal FA multivitaminTabletOralPharmics, Inc.1970-01-15Not applicableUs
O-Cal Prenatal VitaminTabletOralPharmics, Inc.2002-01-23Not applicableUs
O-calcium 250mg Plus DTabletOralVita Health Products Inc1987-12-312005-07-20Canada
Opti-cal Chewable +d CapletTabletOralNu Life Nutrition Ltd.1991-12-312000-05-23Canada
Orifer FTabletOralSanofi Aventis1995-12-312007-11-22Canada
Osteo FormulaTabletOralNutramed Laboratories Inc.Not applicableNot applicableCanada
Osteo Formula TabTabletOralQuest Vitamins A Div Of Purity Life Health Products1994-12-312006-07-25Canada
Osteo TabletsTabletOralQuest Vitamins A Div Of Purity Life Health Products1995-12-312000-07-20Canada
Osteo-lifeTabletOralViva Pharmaceutical Inc.2001-09-012009-12-18Canada
Osteo-plusTabletOralRolmex International Inc.2000-09-152008-07-09Canada
Oyster Shell Calcium with Vitamin DTablet, film coatedOralMc Kesson Packaging Services A Buisness Unit Of Mc Kesson Corporation2005-11-15Not applicableUs
P.N.P. Vitamin DrinkLiquidOralChanges InternationalNot applicableNot applicableCanada
P.R.O. ComplexTabletOralAbundance Marketing Ltd.2000-12-062004-06-30Canada
Paramettes Chewable Multivitamins Plus IronTabletOralWyeth Ayerst Canada Inc.1994-12-312000-08-02Canada
Paramettes Chewable Multivits With Iron TabTabletOralWhitehall Robins Inc.1994-12-311996-09-09Canada
Paramettes Multivits Plus Iron Tab (teens)TabletOralWhitehall Robins Inc.1993-12-311996-09-09Canada
Pediatric Infuvite Multiple VitaminsInjection, solutionIntravenousSandoz2001-02-21Not applicableUs
Pediatric Infuvite Multiple Vitamins for InfusionInjection, solutionIntravenousSandoz2001-02-21Not applicableUs
PM CapsCapsuleOralNew Vision Nutritionals Company1998-10-012002-11-20Canada
PNV Ferrous Fumarate Docusate Folic AcidTabletOralVirtus Pharmaceuticals2014-04-22Not applicableUs
PNV Prenatal Plus MultivitaminTabletOralClinical Solutions Wholsesale2013-04-012017-07-03Us
PNV Prenatal VitaminTablet, chewableOralSancilio & Company Inc.2011-12-20Not applicableUs
PNV Prenatal Vitamin Plus Vitamin ATabletOralSancilio & Company Inc.2012-12-07Not applicableUs
Pnv-dhaCapsule, gelatin coatedOralAcella Pharmaceuticals, LLC2009-11-02Not applicableUs
PNV-FirstTablet, coatedOralAcella Pharmaceuticals, LLC2013-05-17Not applicableUs
PNV-SelectTablet, film coatedOralAcella Pharmaceuticals, LLC2009-11-02Not applicableUs
Port A Mins Super Cal-mag 300/150 With Vitamin D3TabletOralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
Port A Mins Super Calcium 375 With Vitamin D3TabletOralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
Port A Mins Super Calcium 750 With Vitamin D3TabletOralGreat Earth Companies, Inc.1998-08-252002-10-02Canada
Prefera OB plus DHATabletOralAlaven Pharmaceutical2009-04-01Not applicableUs
PreferaOBTablet, coatedOralMeda Pharmaceuticals Ltd2015-04-28Not applicableUs
PreferaOB ONECapsule, liquid filledOralMeda Pharmaceuticals Ltd2015-04-28Not applicableUs
PreferaOB plus DHATabletOralAlaven Pharmaceutical2010-11-15Not applicableUs
PregvitTabletOralDuchesnay Inc.2003-08-252016-07-05Canada
Pregvit Folic 4TabletOralDuchesnay Inc.Not applicableNot applicableCanada
Pregvit Folic 5TabletOralDuchesnay Inc.2006-03-172016-07-05Canada
PrenaissanceCapsule, liquid filledOralAcella Pharmaceuticals, LLC2011-05-192017-09-08Us
Prenaissance PlusCapsule, liquid filledOralAcella Pharmaceuticals, LLC2011-09-12Not applicableUs
PreNatal 19Tablet, coatedOralNationwide Laboratories2013-06-01Not applicableUs
Prenatal PlusTablet, film coatedOralBlenheim Pharmacal, Inc.2010-12-09Not applicableUs65162 0668 50 nlmimage10 120e0910
Prenatal Plus IronTablet, film coatedOralMajor2011-06-07Not applicableUs
PreNatal Vitamins PlusTabletOralbryant ranch prepack2011-04-15Not applicableUs
Prenatal Vitamins Plus Low IronTabletOralPatrin Pharma2013-04-01Not applicableUs39328 0106 10 nlmimage10 df476fdb
Prenatal, DHAKitPure Tek Corporation2017-08-10Not applicableUs
Prenate EliteTablet, coatedOralAvion Pharmaceuticals, Llc2012-08-06Not applicableUs
PRENATE EnhanceCapsule, gelatin coatedOralAvion Pharmaceuticals, Llc2013-09-17Not applicableUs
Prenate EssentialCapsule, gelatin coatedOralAvion Pharmaceuticals, Llc2014-07-18Not applicableUs
Prenate PixieTablet, film coatedOralAvion Pharmaceuticals, Llc2014-08-14Not applicableUs
PRENATE RestoreCapsule, gelatin coatedOralAvion Pharmaceuticals, Llc2013-09-17Not applicableUs
Prenate StarTablet, coatedOralAvion Pharmaceuticals, Llc2014-06-05Not applicableUs
PreNexaCapsule, gelatin coatedOralUpsher Smith Laboratories2010-05-25Not applicableUs
PrePLUSTabletOralVirtus Pharmaceuticals2014-04-04Not applicableUs
PreQue 10TabletOralActavis Pharma Company2011-11-01Not applicableUs
PreTABTabletOralVirtus Pharmaceuticals2014-04-092017-08-08Us
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Categories
UNII1C6V77QF41
CAS number67-97-0
WeightAverage: 384.6377
Monoisotopic: 384.33921603
Chemical FormulaC27H44O
InChI KeyQYSXJUFSXHHAJI-YRZJJWOYSA-N
InChI
InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
IUPAC Name
(1S,3Z)-3-{2-[(1R,3aS,4E,7aR)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-octahydro-1H-inden-4-ylidene]ethylidene}-4-methylidenecyclohexan-1-ol
SMILES
CC(C)CCC[[email protected]@H](C)[[email protected]@]1([H])CC[[email protected]@]2([H])\C(CCC[[email protected]]12C)=C\C=C1\C[[email protected]@H](O)CCC1=C
Pharmacology
Indication

For the treatment of vitamin D deficiency or insufficiency, refractory rickets (vitamin D resistant rickets), familial hypophosphatemia and hypoparathyroidism, and in the management of hypocalcemia and renal osteodystrophy in patients with chronic renal failure undergoing dialysis. Also used in conjunction with calcium in the management and prevention of primary or corticosteroid-induced osteoporosis.

Structured Indications Not Available
Pharmacodynamics

Cholecalciferol (vitamin D3) is a steroid hormone that has long been known for its important role in regulating body levels of calcium and phosphorus, in mineralization of bone, and for the assimilation of Vitamin A. The classical manifestations of vitamin D deficiency is rickets, which is seen in children and results in bony deformaties including bowed long bones. Deficiency in adults leads to the disease osteomalacia. Both rickets and osteomalacia reflect impaired mineralization of newly synthesized bone matrix, and usually result from a combination of inadequate exposure to sunlight and decreased dietary intake of vitamin D. Common causes of vitamin D deficiency include genetic defects in the vitamin D receptor, severe liver or kidney disease, and insufficient exposure to sunlight. Vitamin D plays an important role in maintaining calcium balance and in the regulation of parathyroid hormone (PTH). It promotes renal reabsorption of calcium, increases intestinal absorption of calcium and phosphorus, and increases calcium and phosphorus mobilization from bone to plasma.

Mechanism of action

The first step involved in the activation of vitamin D3 is a 25-hydroxylation which is catalysed by the 25-hydroxylase in the liver and then by other enzymes. The mitochondrial sterol 27-hydroxylase catalyses the first reaction in the oxidation of the side chain of sterol intermediates. The active form of vitamin D3 (calcitriol) binds to intracellular receptors that then function as transcription factors to modulate gene expression. Like the receptors for other steroid hormones and thyroid hormones, the vitamin D receptor has hormone-binding and DNA-binding domains. The vitamin D receptor forms a complex with another intracellular receptor, the retinoid-X receptor, and that heterodimer is what binds to DNA. In most cases studied, the effect is to activate transcription, but situations are also known in which vitamin D suppresses transcription. Calcitriol increases the serum calcium concentrations by: increasing GI absorption of phosphorus and calcium, increasing osteoclastic resorption, and increasing distal renal tubular reabsorption of calcium. Calcitriol appears to promote intestinal absorption of calcium through binding to the vitamin D receptor in the mucosal cytoplasm of the intestine. Subsequently, calcium is absorbed through formation of a calcium-binding protein.

TargetKindPharmacological actionActionsOrganismUniProt ID
Vitamin D3 receptorProteinyes
agonist
HumanP11473 details
Related Articles
Absorption

Readily absorbed

Volume of distributionNot Available
Protein binding

50% to 80%

Metabolism

Within the liver, cholecalciferal is hydroxylated to calcidiol (25-hydroxycholecalciferol) by the enzyme 25-hydroxylase. Within the kidney, calcidiol serves as a substrate for 1-alpha-hydroxylase, yielding calcitriol (1,25-dihydroxycholecalciferol), the biologically active form of vitamin D3.

SubstrateEnzymesProduct
Cholecalciferol
Not Available
(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)Details
Route of eliminationNot Available
Half life

Several weeks

ClearanceNot Available
Toxicity

Hypercalcemia - Early symptoms of hypercalcemia, include nausea and vomiting, weakness, headache, somnolence, dry mouth, constipation, metallic taste, muscle pain and bone pain. Late symptoms and signs of hypercalcemia, include polyuria, polydipsia, anorexia, weight loss, nocturia, conjunctivitis, pancreatitis, photophobia, rhinorrhea, pruritis, hyperthermia, decreased libido, elevated BUN, albuminuria, hypercholesterolemia, elevated ALT (SGPT) and AST (SGOT), ectopic calcification, nephrocalcinosis, hypertension and cardiac arrhythmias.

Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Alendronate Action PathwayDrug actionSMP00095
Zoledronate Action PathwayDrug actionSMP00107
Wolman diseaseDiseaseSMP00511
Pravastatin Action PathwayDrug actionSMP00089
Risedronate Action PathwayDrug actionSMP00112
HypercholesterolemiaDiseaseSMP00209
Rosuvastatin Action PathwayDrug actionSMP00092
Fluvastatin Action PathwayDrug actionSMP00119
CHILD SyndromeDiseaseSMP00387
Hyper-IgD syndromeDiseaseSMP00509
Cerivastatin Action PathwayDrug actionSMP00111
Pamidronate Action PathwayDrug actionSMP00117
Atorvastatin Action PathwayDrug actionSMP00131
Cholesteryl ester storage diseaseDiseaseSMP00508
Mevalonic aciduriaDiseaseSMP00510
Steroid BiosynthesisMetabolicSMP00023
Ibandronate Action PathwayDrug actionSMP00079
Simvastatin Action PathwayDrug actionSMP00082
Lovastatin Action PathwayDrug actionSMP00099
Lysosomal Acid Lipase Deficiency (Wolman Disease)DiseaseSMP00319
DesmosterolosisDiseaseSMP00386
Chondrodysplasia Punctata II, X Linked Dominant (CDPX2)DiseaseSMP00388
Smith-Lemli-Opitz Syndrome (SLOS)DiseaseSMP00389
Pharmacogenomic Effects/ADRs Not Available
Interactions
Drug Interactions
DrugInteractionDrug group
4-MethoxyamphetamineThe metabolism of 4-Methoxyamphetamine can be decreased when combined with Cholecalciferol.Experimental, Illicit
AceclofenacThe metabolism of Aceclofenac can be decreased when combined with Cholecalciferol.Approved
AcenocoumarolThe metabolism of Acenocoumarol can be decreased when combined with Cholecalciferol.Approved
AcetaminophenThe metabolism of Acetaminophen can be decreased when combined with Cholecalciferol.Approved
AcetylcholineThe metabolism of Acetylcholine can be decreased when combined with Cholecalciferol.Approved
AcetyldigitoxinCholecalciferol may increase the arrhythmogenic activities of Acetyldigitoxin.Approved
Acetylsalicylic acidThe metabolism of Acetylsalicylic acid can be decreased when combined with Cholecalciferol.Approved, Vet Approved
AdinazolamThe metabolism of Adinazolam can be decreased when combined with Cholecalciferol.Approved
AjmalineThe metabolism of Ajmaline can be decreased when combined with Cholecalciferol.Approved
AlfacalcidolThe risk or severity of adverse effects can be increased when Cholecalciferol is combined with Alfacalcidol.Approved, Nutraceutical
AlmotriptanThe metabolism of Almotriptan can be decreased when combined with Cholecalciferol.Approved, Investigational
AlogliptinThe metabolism of Alogliptin can be decreased when combined with Cholecalciferol.Approved
AlosetronThe metabolism of Alosetron can be decreased when combined with Cholecalciferol.Approved, Withdrawn
AlprazolamThe metabolism of Alprazolam can be decreased when combined with Cholecalciferol.Approved, Illicit, Investigational
AlprenololThe metabolism of Alprenolol can be decreased when combined with Cholecalciferol.Approved, Withdrawn
Aluminum hydroxideThe serum concentration of Aluminum hydroxide can be increased when it is combined with Cholecalciferol.Approved
AmbrisentanThe metabolism of Ambrisentan can be decreased when combined with Cholecalciferol.Approved, Investigational
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Cholecalciferol.Approved, Withdrawn
AmiodaroneThe metabolism of Cholecalciferol can be decreased when combined with Amiodarone.Approved, Investigational
AmitriptylineThe metabolism of Amitriptyline can be decreased when combined with Cholecalciferol.Approved
AmodiaquineThe serum concentration of Amodiaquine can be increased when it is combined with Cholecalciferol.Approved
AmoxapineThe metabolism of Amoxapine can be decreased when combined with Cholecalciferol.Approved
AmoxicillinThe metabolism of Amoxicillin can be decreased when combined with Cholecalciferol.Approved, Vet Approved
AmphetamineThe metabolism of Amphetamine can be decreased when combined with Cholecalciferol.Approved, Illicit
AmprenavirThe metabolism of Amprenavir can be decreased when combined with Cholecalciferol.Approved
AmsacrineThe metabolism of Amsacrine can be decreased when combined with Cholecalciferol.Approved
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Cholecalciferol.Approved
ApixabanThe metabolism of Apixaban can be decreased when combined with Cholecalciferol.Approved
AprepitantThe serum concentration of Cholecalciferol can be increased when it is combined with Aprepitant.Approved, Investigational
AprindineThe metabolism of Aprindine can be decreased when combined with Cholecalciferol.Approved
Arachidonic AcidThe metabolism of Arachidonic Acid can be decreased when combined with Cholecalciferol.Experimental
ArformoterolThe metabolism of Arformoterol can be decreased when combined with Cholecalciferol.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Cholecalciferol.Approved, Investigational
ArtemetherThe metabolism of Artemether can be decreased when combined with Cholecalciferol.Approved
AstemizoleThe metabolism of Astemizole can be decreased when combined with Cholecalciferol.Approved, Withdrawn
AtazanavirThe metabolism of Cholecalciferol can be decreased when combined with Atazanavir.Approved, Investigational
AtomoxetineThe metabolism of Cholecalciferol can be decreased when combined with Atomoxetine.Approved
AxitinibThe metabolism of Axitinib can be decreased when combined with Cholecalciferol.Approved, Investigational
AzelastineThe metabolism of Azelastine can be decreased when combined with Cholecalciferol.Approved
BendroflumethiazideBendroflumethiazide may increase the hypercalcemic activities of Cholecalciferol.Approved
BenzatropineThe metabolism of Benzatropine can be decreased when combined with Cholecalciferol.Approved
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Cholecalciferol.Approved
BepridilThe metabolism of Bepridil can be decreased when combined with Cholecalciferol.Approved, Withdrawn
BetaxololThe metabolism of Betaxolol can be decreased when combined with Cholecalciferol.Approved
BexaroteneThe serum concentration of Cholecalciferol can be decreased when it is combined with Bexarotene.Approved, Investigational
BisoprololThe metabolism of Bisoprolol can be decreased when combined with Cholecalciferol.Approved
BoceprevirThe metabolism of Cholecalciferol can be decreased when combined with Boceprevir.Withdrawn
BortezomibThe metabolism of Cholecalciferol can be decreased when combined with Bortezomib.Approved, Investigational
BosentanThe serum concentration of Bosentan can be increased when it is combined with Cholecalciferol.Approved, Investigational
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Cholecalciferol.Approved
BromazepamThe metabolism of Bromazepam can be decreased when combined with Cholecalciferol.Approved, Illicit
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Cholecalciferol.Approved
BufuralolThe metabolism of Bufuralol can be decreased when combined with Cholecalciferol.Experimental, Investigational
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Cholecalciferol.Approved, Investigational
BuprenorphineThe metabolism of Buprenorphine can be decreased when combined with Cholecalciferol.Approved, Illicit, Investigational, Vet Approved
BupropionThe metabolism of Bupropion can be decreased when combined with Cholecalciferol.Approved
BuspironeThe metabolism of Buspirone can be decreased when combined with Cholecalciferol.Approved, Investigational
CabozantinibThe metabolism of Cabozantinib can be decreased when combined with Cholecalciferol.Approved
CaffeineThe metabolism of Caffeine can be decreased when combined with Cholecalciferol.Approved
CalcidiolThe risk or severity of adverse effects can be increased when Calcidiol is combined with Cholecalciferol.Approved, Nutraceutical
CalcipotriolThe risk or severity of adverse effects can be increased when Cholecalciferol is combined with Calcipotriol.Approved
CalcitriolThe risk or severity of adverse effects can be increased when Calcitriol is combined with Cholecalciferol.Approved, Nutraceutical
CalciumThe risk or severity of adverse effects can be increased when Calcium is combined with Cholecalciferol.Nutraceutical
Calcium AcetateThe risk or severity of adverse effects can be increased when Calcium Acetate is combined with Cholecalciferol.Approved
Calcium CarbonateThe risk or severity of adverse effects can be increased when Calcium carbonate is combined with Cholecalciferol.Approved
Calcium ChlorideThe risk or severity of adverse effects can be increased when Calcium Chloride is combined with Cholecalciferol.Approved
Calcium CitrateThe risk or severity of adverse effects can be increased when Calcium citrate is combined with Cholecalciferol.Approved
Calcium glubionateThe risk or severity of adverse effects can be increased when Calcium glubionate is combined with Cholecalciferol.Approved
Calcium GluceptateThe risk or severity of adverse effects can be increased when Calcium Gluceptate is combined with Cholecalciferol.Approved
Calcium gluconateThe risk or severity of adverse effects can be increased when Calcium gluconate is combined with Cholecalciferol.Approved, Vet Approved
CandesartanThe metabolism of Candesartan can be decreased when combined with Cholecalciferol.Approved
CaptoprilThe metabolism of Captopril can be decreased when combined with Cholecalciferol.Approved
CarbamazepineThe metabolism of Cholecalciferol can be increased when combined with Carbamazepine.Approved, Investigational
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Cholecalciferol.Approved
CariprazineThe metabolism of Cariprazine can be decreased when combined with Cholecalciferol.Approved
CarisoprodolThe metabolism of Carisoprodol can be decreased when combined with Cholecalciferol.Approved
CarteololThe metabolism of Carteolol can be decreased when combined with Cholecalciferol.Approved
CarvedilolThe serum concentration of Carvedilol can be increased when it is combined with Cholecalciferol.Approved, Investigational
CelecoxibThe metabolism of Celecoxib can be decreased when combined with Cholecalciferol.Approved, Investigational
CephalexinThe metabolism of Cephalexin can be decreased when combined with Cholecalciferol.Approved, Vet Approved
CeritinibThe serum concentration of Cholecalciferol can be increased when it is combined with Ceritinib.Approved
CevimelineThe metabolism of Cevimeline can be decreased when combined with Cholecalciferol.Approved
ChloramphenicolThe metabolism of Chloramphenicol can be decreased when combined with Cholecalciferol.Approved, Vet Approved
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Cholecalciferol.Approved, Illicit
ChloroquineThe metabolism of Chloroquine can be decreased when combined with Cholecalciferol.Approved, Vet Approved
ChlorothiazideChlorothiazide may increase the hypercalcemic activities of Cholecalciferol.Approved, Vet Approved
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Cholecalciferol.Approved
ChlorpromazineThe metabolism of Chlorpromazine can be decreased when combined with Cholecalciferol.Approved, Vet Approved
ChlorpropamideThe metabolism of Chlorpropamide can be decreased when combined with Cholecalciferol.Approved
ChlorthalidoneChlorthalidone may increase the hypercalcemic activities of Cholecalciferol.Approved
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Cholecalciferol.Approved
CholestyramineThe serum concentration of Cholecalciferol can be decreased when it is combined with Cholestyramine.Approved
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Cholecalciferol.Approved
CinnarizineThe metabolism of Cinnarizine can be decreased when combined with Cholecalciferol.Approved
CisaprideThe metabolism of Cisapride can be decreased when combined with Cholecalciferol.Approved, Investigational, Withdrawn
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Cholecalciferol.Approved
ClarithromycinThe metabolism of Cholecalciferol can be decreased when combined with Clarithromycin.Approved
ClemastineThe metabolism of Cholecalciferol can be decreased when combined with Clemastine.Approved
ClevidipineThe metabolism of Clevidipine can be decreased when combined with Cholecalciferol.Approved
ClobazamThe metabolism of Clobazam can be decreased when combined with Cholecalciferol.Approved, Illicit
clomethiazoleThe metabolism of clomethiazole can be decreased when combined with Cholecalciferol.Investigational
ClomipramineThe metabolism of Clomipramine can be decreased when combined with Cholecalciferol.Approved, Vet Approved
ClonidineThe metabolism of Clonidine can be decreased when combined with Cholecalciferol.Approved
ClopidogrelThe serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Cholecalciferol resulting in a loss in efficacy.Approved, Nutraceutical
ClotiazepamThe metabolism of Clotiazepam can be decreased when combined with Cholecalciferol.Approved, Illicit
ClotrimazoleThe metabolism of Cholecalciferol can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineThe metabolism of Clozapine can be decreased when combined with Cholecalciferol.Approved
CobicistatThe metabolism of Cholecalciferol can be decreased when combined with Cobicistat.Approved
CodeineThe therapeutic efficacy of Codeine can be decreased when used in combination with Cholecalciferol.Approved, Illicit
ColesevelamThe serum concentration of Cholecalciferol can be decreased when it is combined with Colesevelam.Approved
ColestipolThe serum concentration of Cholecalciferol can be decreased when it is combined with Colestipol.Approved
ConivaptanThe serum concentration of Cholecalciferol can be increased when it is combined with Conivaptan.Approved, Investigational
CrizotinibThe metabolism of Cholecalciferol can be decreased when combined with Crizotinib.Approved
CyclobenzaprineThe metabolism of Cyclobenzaprine can be decreased when combined with Cholecalciferol.Approved
CyclophosphamideThe metabolism of Cyclophosphamide can be decreased when combined with Cholecalciferol.Approved, Investigational
CyclosporineThe metabolism of Cholecalciferol can be decreased when combined with Cyclosporine.Approved, Investigational, Vet Approved
DabrafenibThe serum concentration of Cholecalciferol can be decreased when it is combined with Dabrafenib.Approved
DanazolDanazol may increase the hypercalcemic activities of Cholecalciferol.Approved
DapagliflozinThe metabolism of Dapagliflozin can be decreased when combined with Cholecalciferol.Approved
DapsoneThe metabolism of Dapsone can be decreased when combined with Cholecalciferol.Approved, Investigational
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Cholecalciferol.Approved, Investigational
DarunavirThe metabolism of Cholecalciferol can be decreased when combined with Darunavir.Approved
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Cholecalciferol.Approved
DasatinibThe serum concentration of Cholecalciferol can be increased when it is combined with Dasatinib.Approved, Investigational
DebrisoquinThe metabolism of Debrisoquin can be decreased when combined with Cholecalciferol.Approved
DeferasiroxThe serum concentration of Cholecalciferol can be decreased when it is combined with Deferasirox.Approved, Investigational
DelavirdineThe metabolism of Cholecalciferol can be decreased when combined with Delavirdine.Approved
DesipramineThe metabolism of Desipramine can be decreased when combined with Cholecalciferol.Approved
DeslanosideCholecalciferol may increase the arrhythmogenic activities of Deslanoside.Approved
DexamethasoneThe serum concentration of Cholecalciferol can be decreased when it is combined with Dexamethasone.Approved, Investigational, Vet Approved
DexfenfluramineThe metabolism of Dexfenfluramine can be decreased when combined with Cholecalciferol.Approved, Illicit, Withdrawn
DexmethylphenidateThe metabolism of Dexmethylphenidate can be decreased when combined with Cholecalciferol.Approved
DextroamphetamineThe metabolism of Dextroamphetamine can be decreased when combined with Cholecalciferol.Approved, Illicit
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Cholecalciferol.Approved
DiazepamThe metabolism of Diazepam can be decreased when combined with Cholecalciferol.Approved, Illicit, Vet Approved
DiclofenacThe metabolism of Diclofenac can be decreased when combined with Cholecalciferol.Approved, Vet Approved
DicoumarolThe metabolism of Dicoumarol can be decreased when combined with Cholecalciferol.Approved
DigitoxinCholecalciferol may increase the arrhythmogenic activities of Digitoxin.Approved
DigoxinCholecalciferol may increase the arrhythmogenic activities of Digoxin.Approved
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Cholecalciferol.Approved, Illicit
DihydroergotamineThe metabolism of Cholecalciferol can be decreased when combined with Dihydroergotamine.Approved
DihydrotachysterolThe risk or severity of adverse effects can be increased when Cholecalciferol is combined with Dihydrotachysterol.Approved
DiltiazemThe metabolism of Cholecalciferol can be decreased when combined with Diltiazem.Approved
DiphenhydramineThe metabolism of Diphenhydramine can be decreased when combined with Cholecalciferol.Approved
DolasetronThe metabolism of Dolasetron can be decreased when combined with Cholecalciferol.Approved
DomperidoneThe metabolism of Domperidone can be decreased when combined with Cholecalciferol.Approved, Investigational, Vet Approved
DonepezilThe metabolism of Donepezil can be decreased when combined with Cholecalciferol.Approved
DopamineThe metabolism of Dopamine can be decreased when combined with Cholecalciferol.Approved
DorzolamideThe metabolism of Dorzolamide can be decreased when combined with Cholecalciferol.Approved
DoxazosinThe metabolism of Doxazosin can be decreased when combined with Cholecalciferol.Approved
DoxepinThe metabolism of Doxepin can be decreased when combined with Cholecalciferol.Approved
DoxercalciferolThe risk or severity of adverse effects can be increased when Cholecalciferol is combined with Doxercalciferol.Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Cholecalciferol.Approved, Investigational
DoxorubicinThe metabolism of Doxorubicin can be decreased when combined with Cholecalciferol.Approved, Investigational
DoxycyclineThe metabolism of Cholecalciferol can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Cholecalciferol.Approved, Illicit
DronedaroneThe metabolism of Cholecalciferol can be decreased when combined with Dronedarone.Approved
DuloxetineThe metabolism of Duloxetine can be decreased when combined with Cholecalciferol.Approved
EfavirenzThe serum concentration of Cholecalciferol can be decreased when it is combined with Efavirenz.Approved, Investigational
EletriptanThe metabolism of Eletriptan can be decreased when combined with Cholecalciferol.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Cholecalciferol.Approved
EncainideThe metabolism of Encainide can be decreased when combined with Cholecalciferol.Approved, Withdrawn
EnclomipheneThe metabolism of Enclomiphene can be decreased when combined with Cholecalciferol.Investigational
EnfuvirtideThe metabolism of Enfuvirtide can be decreased when combined with Cholecalciferol.Approved, Investigational
EnzalutamideThe serum concentration of Cholecalciferol can be decreased when it is combined with Enzalutamide.Approved
EpinastineThe metabolism of Epinastine can be decreased when combined with Cholecalciferol.Approved, Investigational
EpoprostenolThe metabolism of Epoprostenol can be decreased when combined with Cholecalciferol.Approved
ErgocalciferolThe risk or severity of adverse effects can be increased when Ergocalciferol is combined with Cholecalciferol.Approved, Nutraceutical
ErlotinibThe metabolism of Erlotinib can be decreased when combined with Cholecalciferol.Approved, Investigational
ErythromycinThe metabolism of Cholecalciferol can be decreased when combined with Erythromycin.Approved, Vet Approved
EscitalopramThe metabolism of Escitalopram can be decreased when combined with Cholecalciferol.Approved, Investigational
Eslicarbazepine acetateThe serum concentration of Cholecalciferol can be decreased when it is combined with Eslicarbazepine acetate.Approved
EsmirtazapineThe metabolism of Esmirtazapine can be decreased when combined with Cholecalciferol.Investigational
EsomeprazoleThe metabolism of Esomeprazole can be decreased when combined with Cholecalciferol.Approved, Investigational
EstradiolThe metabolism of Estradiol can be decreased when combined with Cholecalciferol.Approved, Investigational, Vet Approved
EstroneThe metabolism of Estrone can be decreased when combined with Cholecalciferol.Approved
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Cholecalciferol.Approved
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Cholecalciferol.Approved, Illicit
EtodolacThe metabolism of Etodolac can be decreased when combined with Cholecalciferol.Approved, Investigational, Vet Approved
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Cholecalciferol.Approved, Investigational
EtravirineThe serum concentration of Cholecalciferol can be decreased when it is combined with Etravirine.Approved
FamotidineThe metabolism of Famotidine can be decreased when combined with Cholecalciferol.Approved
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Cholecalciferol.Approved
FingolimodThe metabolism of Fingolimod can be decreased when combined with Cholecalciferol.Approved, Investigational
FlecainideThe metabolism of Flecainide can be decreased when combined with Cholecalciferol.Approved, Withdrawn
FluconazoleThe metabolism of Cholecalciferol can be decreased when combined with Fluconazole.Approved
FlunarizineThe metabolism of Flunarizine can be decreased when combined with Cholecalciferol.Approved
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Cholecalciferol.Approved, Illicit
FluoxetineThe metabolism of Fluoxetine can be decreased when combined with Cholecalciferol.Approved, Vet Approved
FluphenazineThe metabolism of Fluphenazine can be decreased when combined with Cholecalciferol.Approved
FlurbiprofenThe metabolism of Flurbiprofen can be decreased when combined with Cholecalciferol.Approved, Investigational
FlutamideThe metabolism of Flutamide can be decreased when combined with Cholecalciferol.Approved
FluvastatinThe metabolism of Fluvastatin can be decreased when combined with Cholecalciferol.Approved
FluvoxamineThe metabolism of Cholecalciferol can be decreased when combined with Fluvoxamine.Approved, Investigational
FormoterolThe metabolism of Formoterol can be decreased when combined with Cholecalciferol.Approved, Investigational
FosamprenavirThe metabolism of Cholecalciferol can be decreased when combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Cholecalciferol can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinThe metabolism of Cholecalciferol can be increased when combined with Fosphenytoin.Approved
Fusidic AcidThe serum concentration of Cholecalciferol can be increased when it is combined with Fusidic Acid.Approved
GalantamineThe metabolism of Galantamine can be decreased when combined with Cholecalciferol.Approved
GavestinelThe metabolism of Gavestinel can be decreased when combined with Cholecalciferol.Investigational
GefitinibThe metabolism of Gefitinib can be decreased when combined with Cholecalciferol.Approved, Investigational
GliclazideThe metabolism of Gliclazide can be decreased when combined with Cholecalciferol.Approved
GlimepirideThe metabolism of Glimepiride can be decreased when combined with Cholecalciferol.Approved
GlipizideThe metabolism of Glipizide can be decreased when combined with Cholecalciferol.Approved
GlucosamineThe metabolism of Glucosamine can be decreased when combined with Cholecalciferol.Approved
GlyburideThe metabolism of Glyburide can be decreased when combined with Cholecalciferol.Approved
GranisetronThe metabolism of Granisetron can be decreased when combined with Cholecalciferol.Approved, Investigational
GuanfacineThe metabolism of Guanfacine can be decreased when combined with Cholecalciferol.Approved, Investigational
HalofantrineThe metabolism of Halofantrine can be decreased when combined with Cholecalciferol.Approved
HaloperidolThe metabolism of Haloperidol can be decreased when combined with Cholecalciferol.Approved
HalothaneThe metabolism of Halothane can be decreased when combined with Cholecalciferol.Approved, Vet Approved
HexobarbitalThe metabolism of Hexobarbital can be decreased when combined with Cholecalciferol.Approved
HistamineThe metabolism of Histamine Phosphate can be decreased when combined with Cholecalciferol.Approved, Investigational
HydrochlorothiazideHydrochlorothiazide may increase the hypercalcemic activities of Cholecalciferol.Approved, Vet Approved
HydrocodoneThe metabolism of Hydrocodone can be decreased when combined with Cholecalciferol.Approved, Illicit
HydroflumethiazideHydroflumethiazide may increase the hypercalcemic activities of Cholecalciferol.Approved
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Cholecalciferol.Approved, Illicit
IbrutinibThe metabolism of Ibrutinib can be decreased when combined with Cholecalciferol.Approved
IbuprofenThe metabolism of Ibuprofen can be decreased when combined with Cholecalciferol.Approved
IdarubicinThe metabolism of Idarubicin can be decreased when combined with Cholecalciferol.Approved
IdelalisibThe serum concentration of Cholecalciferol can be increased when it is combined with Idelalisib.Approved
IfosfamideThe metabolism of Ifosfamide can be decreased when combined with Cholecalciferol.Approved
IloperidoneThe metabolism of Iloperidone can be decreased when combined with Cholecalciferol.Approved
ImatinibThe metabolism of Cholecalciferol can be decreased when combined with Imatinib.Approved
ImipramineThe metabolism of Imipramine can be decreased when combined with Cholecalciferol.Approved
IndapamideIndapamide may increase the hypercalcemic activities of Cholecalciferol.Approved
IndinavirThe metabolism of Cholecalciferol can be decreased when combined with Indinavir.Approved
indisulamThe metabolism of indisulam can be decreased when combined with Cholecalciferol.Investigational
IndomethacinThe metabolism of Indomethacin can be decreased when combined with Cholecalciferol.Approved, Investigational
Ipratropium bromideThe metabolism of Ipratropium bromide can be decreased when combined with Cholecalciferol.Approved
IrbesartanThe metabolism of Irbesartan can be decreased when combined with Cholecalciferol.Approved, Investigational
IsavuconazoniumThe metabolism of Cholecalciferol can be decreased when combined with Isavuconazonium.Approved, Investigational
IsradipineThe metabolism of Cholecalciferol can be decreased when combined with Isradipine.Approved
ItraconazoleThe metabolism of Cholecalciferol can be decreased when combined with Itraconazole.Approved, Investigational
IvacaftorThe serum concentration of Cholecalciferol can be increased when it is combined with Ivacaftor.Approved
IxazomibThe metabolism of Ixazomib can be decreased when combined with Cholecalciferol.Approved
KetamineThe metabolism of Ketamine can be decreased when combined with Cholecalciferol.Approved, Vet Approved
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Cholecalciferol.Approved
KetoconazoleThe metabolism of Cholecalciferol can be decreased when combined with Ketoconazole.Approved, Investigational
KetoprofenThe metabolism of Ketoprofen can be decreased when combined with Cholecalciferol.Approved, Vet Approved
LabetalolThe metabolism of Labetalol can be decreased when combined with Cholecalciferol.Approved
LansoprazoleThe metabolism of Lansoprazole can be decreased when combined with Cholecalciferol.Approved, Investigational
LapatinibThe metabolism of Lapatinib can be decreased when combined with Cholecalciferol.Approved, Investigational
LeflunomideThe metabolism of Leflunomide can be decreased when combined with Cholecalciferol.Approved, Investigational
LesinuradThe metabolism of Lesinurad can be decreased when combined with Cholecalciferol.Approved
LevodopaThe metabolism of Levodopa can be decreased when combined with Cholecalciferol.Approved
LevomilnacipranThe metabolism of Levomilnacipran can be decreased when combined with Cholecalciferol.Approved
LicofeloneThe metabolism of Licofelone can be decreased when combined with Cholecalciferol.Investigational
LidocaineThe metabolism of Lidocaine can be decreased when combined with Cholecalciferol.Approved, Vet Approved
LisurideThe metabolism of Lisuride can be decreased when combined with Cholecalciferol.Approved
LomustineThe metabolism of Lomustine can be decreased when combined with Cholecalciferol.Approved
LoperamideThe metabolism of Loperamide can be decreased when combined with Cholecalciferol.Approved
LopinavirThe metabolism of Cholecalciferol can be decreased when combined with Lopinavir.Approved
LoratadineThe metabolism of Loratadine can be decreased when combined with Cholecalciferol.Approved
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Cholecalciferol.Approved
LornoxicamThe metabolism of Lornoxicam can be decreased when combined with Cholecalciferol.Approved
LosartanThe metabolism of Losartan can be decreased when combined with Cholecalciferol.Approved
LovastatinThe metabolism of Cholecalciferol can be decreased when combined with Lovastatin.Approved, Investigational
LuliconazoleThe serum concentration of Cholecalciferol can be increased when it is combined with Luliconazole.Approved
LumacaftorThe metabolism of Cholecalciferol can be increased when combined with Lumacaftor.Approved
LumiracoxibThe metabolism of Lumiracoxib can be decreased when combined with Cholecalciferol.Approved, Investigational
MacitentanThe metabolism of Macitentan can be decreased when combined with Cholecalciferol.Approved
MaprotilineThe metabolism of Maprotiline can be decreased when combined with Cholecalciferol.Approved
Mefenamic acidThe metabolism of Mefenamic acid can be decreased when combined with Cholecalciferol.Approved
MelatoninThe metabolism of Melatonin can be decreased when combined with Cholecalciferol.Approved, Nutraceutical, Vet Approved
MeloxicamThe metabolism of Meloxicam can be decreased when combined with Cholecalciferol.Approved, Vet Approved
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Cholecalciferol.Investigational, Withdrawn
MeprobamateThe metabolism of Meprobamate can be decreased when combined with Cholecalciferol.Approved, Illicit
MequitazineThe metabolism of Mequitazine can be decreased when combined with Cholecalciferol.Approved
MesoridazineThe metabolism of Mesoridazine can be decreased when combined with Cholecalciferol.Approved
MestranolThe metabolism of Mestranol can be decreased when combined with Cholecalciferol.Approved
MethadoneThe metabolism of Methadone can be decreased when combined with Cholecalciferol.Approved
MethamphetamineThe metabolism of Methamphetamine can be decreased when combined with Cholecalciferol.Approved, Illicit
MethotrimeprazineThe metabolism of Methotrimeprazine can be decreased when combined with Cholecalciferol.Approved
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Cholecalciferol.Approved, Vet Approved
MethsuximideThe metabolism of Methsuximide can be decreased when combined with Cholecalciferol.Approved
MethyclothiazideMethyclothiazide may increase the hypercalcemic activities of Cholecalciferol.Approved
MethylphenidateThe metabolism of Methylphenidate can be decreased when combined with Cholecalciferol.Approved, Investigational
MethylphenobarbitalThe metabolism of Methylphenobarbital can be decreased when combined with Cholecalciferol.Approved
MethyprylonThe metabolism of Methyprylon can be decreased when combined with Cholecalciferol.Approved, Illicit, Withdrawn
MetoclopramideThe metabolism of Metoclopramide can be decreased when combined with Cholecalciferol.Approved, Investigational
MetolazoneMetolazone may increase the hypercalcemic activities of Cholecalciferol.Approved
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Cholecalciferol.Approved, Investigational
MetronidazoleThe metabolism of Metronidazole can be decreased when combined with Cholecalciferol.Approved
MexiletineThe metabolism of Mexiletine can be decreased when combined with Cholecalciferol.Approved
MianserinThe metabolism of Mianserin can be decreased when combined with Cholecalciferol.Approved
MifepristoneThe serum concentration of Cholecalciferol can be increased when it is combined with Mifepristone.Approved, Investigational
MinaprineThe metabolism of Minaprine can be decreased when combined with Cholecalciferol.Approved
Mineral oilThe serum concentration of Cholecalciferol can be decreased when it is combined with Mineral oil.Approved, Vet Approved
MirabegronThe metabolism of Mirabegron can be decreased when combined with Cholecalciferol.Approved
MirtazapineThe metabolism of Mirtazapine can be decreased when combined with Cholecalciferol.Approved
MitotaneThe serum concentration of Cholecalciferol can be decreased when it is combined with Mitotane.Approved
MoclobemideThe metabolism of Moclobemide can be decreased when combined with Cholecalciferol.Approved
ModafinilThe serum concentration of Cholecalciferol can be decreased when it is combined with Modafinil.Approved, Investigational
MontelukastThe metabolism of Montelukast can be decreased when combined with Cholecalciferol.Approved
MorphineThe metabolism of Morphine can be decreased when combined with Cholecalciferol.Approved, Investigational
NafcillinThe serum concentration of Cholecalciferol can be decreased when it is combined with Nafcillin.Approved
NaproxenThe metabolism of Naproxen can be decreased when combined with Cholecalciferol.Approved, Vet Approved
NateglinideThe metabolism of Nateglinide can be decreased when combined with Cholecalciferol.Approved, Investigational
NebivololThe serum concentration of Nebivolol can be increased when it is combined with Cholecalciferol.Approved, Investigational
NefazodoneThe metabolism of Cholecalciferol can be decreased when combined with Nefazodone.Approved, Withdrawn
NelfinavirThe metabolism of Cholecalciferol can be decreased when combined with Nelfinavir.Approved
NetupitantThe serum concentration of Cholecalciferol can be increased when it is combined with Netupitant.Approved
NevirapineThe metabolism of Cholecalciferol can be increased when combined with Nevirapine.Approved
NicardipineThe metabolism of Nicardipine can be decreased when combined with Cholecalciferol.Approved
NicergolineThe metabolism of Nicergoline can be decreased when combined with Cholecalciferol.Approved
NiclosamideThe metabolism of Niclosamide can be decreased when combined with Cholecalciferol.Approved, Vet Approved
NicotineThe metabolism of Nicotine can be decreased when combined with Cholecalciferol.Approved
NifedipineThe metabolism of Nifedipine can be decreased when combined with Cholecalciferol.Approved
NilotinibThe metabolism of Cholecalciferol can be decreased when combined with Nilotinib.Approved, Investigational
NilutamideThe metabolism of Nilutamide can be decreased when combined with Cholecalciferol.Approved
NitrofuralThe metabolism of Nitrofural can be decreased when combined with Cholecalciferol.Approved, Vet Approved
NortriptylineThe metabolism of Nortriptyline can be decreased when combined with Cholecalciferol.Approved
OlanzapineThe metabolism of Olanzapine can be decreased when combined with Cholecalciferol.Approved, Investigational
OlaparibThe metabolism of Cholecalciferol can be decreased when combined with Olaparib.Approved
OleandrinCholecalciferol may increase the arrhythmogenic activities of Anvirzel.Experimental
OlodaterolThe metabolism of Olodaterol can be decreased when combined with Cholecalciferol.Approved
OmeprazoleThe metabolism of Omeprazole can be decreased when combined with Cholecalciferol.Approved, Investigational, Vet Approved
OndansetronThe metabolism of Ondansetron can be decreased when combined with Cholecalciferol.Approved
OrlistatThe serum concentration of Cholecalciferol can be decreased when it is combined with Orlistat.Approved, Investigational
OsimertinibThe serum concentration of Cholecalciferol can be increased when it is combined with Osimertinib.Approved
OspemifeneThe metabolism of Ospemifene can be decreased when combined with Cholecalciferol.Approved
OuabainCholecalciferol may increase the arrhythmogenic activities of Ouabain.Approved
OxaprozinThe metabolism of Oxaprozin can be decreased when combined with Cholecalciferol.Approved
OxiconazoleThe metabolism of Oxiconazole can be decreased when combined with Cholecalciferol.Approved
OxycodoneThe metabolism of Oxycodone can be decreased when combined with Cholecalciferol.Approved, Illicit, Investigational
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Cholecalciferol.Approved, Investigational, Vet Approved
PaclitaxelThe metabolism of Paclitaxel can be decreased when combined with Cholecalciferol.Approved, Vet Approved
PalbociclibThe serum concentration of Cholecalciferol can be increased when it is combined with Palbociclib.Approved
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Cholecalciferol.Approved, Investigational
PantoprazoleThe metabolism of Pantoprazole can be decreased when combined with Cholecalciferol.Approved
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Cholecalciferol.Approved
ParecoxibThe metabolism of Parecoxib can be decreased when combined with Cholecalciferol.Approved
ParicalcitolThe risk or severity of adverse effects can be increased when Cholecalciferol is combined with Paricalcitol.Approved, Investigational
ParoxetineThe metabolism of Paroxetine can be decreased when combined with Cholecalciferol.Approved, Investigational
PazopanibThe metabolism of Pazopanib can be decreased when combined with Cholecalciferol.Approved
PentamidineThe metabolism of Pentamidine can be decreased when combined with Cholecalciferol.Approved
PentobarbitalThe metabolism of Cholecalciferol can be increased when combined with Pentobarbital.Approved, Vet Approved
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Cholecalciferol.Approved
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Cholecalciferol.Approved
PethidineThe metabolism of Pethidine can be decreased when combined with Cholecalciferol.Approved
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Cholecalciferol.Withdrawn
PhenforminThe metabolism of Phenformin can be decreased when combined with Cholecalciferol.Approved, Withdrawn
PhenobarbitalThe metabolism of Cholecalciferol can be increased when combined with Phenobarbital.Approved
PhenprocoumonThe metabolism of Phenprocoumon can be decreased when combined with Cholecalciferol.Approved
PhenylbutazoneThe metabolism of Phenylbutazone can be decreased when combined with Cholecalciferol.Approved, Vet Approved
PhenytoinThe metabolism of Cholecalciferol can be increased when combined with Phenytoin.Approved, Vet Approved
PindololThe metabolism of Pindolol can be decreased when combined with Cholecalciferol.Approved
PioglitazoneThe metabolism of Pioglitazone can be decreased when combined with Cholecalciferol.Approved, Investigational
PiperazineThe metabolism of Piperazine can be decreased when combined with Cholecalciferol.Approved, Vet Approved
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Cholecalciferol.Approved
PiroxicamThe metabolism of Piroxicam can be decreased when combined with Cholecalciferol.Approved, Investigational
PitavastatinThe metabolism of Pitavastatin can be decreased when combined with Cholecalciferol.Approved
PodofiloxThe metabolism of Podofilox can be decreased when combined with Cholecalciferol.Approved
PolythiazidePolythiazide may increase the hypercalcemic activities of Cholecalciferol.Approved
PonatinibThe metabolism of Ponatinib can be decreased when combined with Cholecalciferol.Approved
PosaconazoleThe metabolism of Cholecalciferol can be decreased when combined with Posaconazole.Approved, Investigational, Vet Approved
PrasugrelThe metabolism of Prasugrel can be decreased when combined with Cholecalciferol.Approved
PravastatinThe metabolism of Pravastatin can be decreased when combined with Cholecalciferol.Approved
PraziquantelThe metabolism of Praziquantel can be decreased when combined with Cholecalciferol.Approved, Vet Approved
PrimidoneThe metabolism of Cholecalciferol can be increased when combined with Primidone.Approved, Vet Approved
ProcainamideThe metabolism of Procainamide can be decreased when combined with Cholecalciferol.Approved
ProchlorperazineThe metabolism of Prochlorperazine can be decreased when combined with Cholecalciferol.Approved, Vet Approved
ProgesteroneThe metabolism of Progesterone can be decreased when combined with Cholecalciferol.Approved, Vet Approved
ProguanilThe metabolism of Proguanil can be decreased when combined with Cholecalciferol.Approved
PromazineThe metabolism of Promazine can be decreased when combined with Cholecalciferol.Approved, Vet Approved
PromethazineThe metabolism of Promethazine can be decreased when combined with Cholecalciferol.Approved
PropafenoneThe serum concentration of Cholecalciferol can be increased when it is combined with Propafenone.Approved
PropofolThe metabolism of Propofol can be decreased when combined with Cholecalciferol.Approved, Investigational, Vet Approved
PropranololThe metabolism of Propranolol can be decreased when combined with Cholecalciferol.Approved, Investigational
ProtriptylineThe metabolism of Protriptyline can be decreased when combined with Cholecalciferol.Approved
PseudoephedrineThe metabolism of Pseudoephedrine can be decreased when combined with Cholecalciferol.Approved
QuazepamThe metabolism of Quazepam can be decreased when combined with Cholecalciferol.Approved, Illicit
QuetiapineThe metabolism of Quetiapine can be decreased when combined with Cholecalciferol.Approved
QuinethazoneQuinethazone may increase the hypercalcemic activities of Cholecalciferol.Approved
QuinidineThe metabolism of Quinidine can be decreased when combined with Cholecalciferol.Approved
QuinineThe metabolism of Quinine can be decreased when combined with Cholecalciferol.Approved
RabeprazoleThe metabolism of Rabeprazole can be decreased when combined with Cholecalciferol.Approved, Investigational
RamelteonThe metabolism of Ramelteon can be decreased when combined with Cholecalciferol.Approved, Investigational
RanitidineThe metabolism of Ranitidine can be decreased when combined with Cholecalciferol.Approved
RanolazineThe metabolism of Cholecalciferol can be decreased when combined with Ranolazine.Approved, Investigational
RemoxiprideThe metabolism of Remoxipride can be decreased when combined with Cholecalciferol.Approved, Withdrawn
repinotanThe metabolism of repinotan can be decreased when combined with Cholecalciferol.Investigational
RifabutinThe metabolism of Cholecalciferol can be increased when combined with Rifabutin.Approved
RifampicinThe metabolism of Cholecalciferol can be increased when combined with Rifampicin.Approved
RifapentineThe metabolism of Cholecalciferol can be increased when combined with Rifapentine.Approved
RisperidoneThe metabolism of Risperidone can be decreased when combined with Cholecalciferol.Approved, Investigational
RitonavirThe metabolism of Cholecalciferol can be decreased when combined with Ritonavir.Approved, Investigational
RofecoxibThe metabolism of Rofecoxib can be decreased when combined with Cholecalciferol.Investigational, Withdrawn
RomidepsinThe metabolism of Romidepsin can be decreased when combined with Cholecalciferol.Approved, Investigational
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Cholecalciferol.Approved
RosiglitazoneThe metabolism of Rosiglitazone can be decreased when combined with Cholecalciferol.Approved, Investigational
RosuvastatinThe metabolism of Rosuvastatin can be decreased when combined with Cholecalciferol.Approved
RotigotineThe metabolism of Rotigotine can be decreased when combined with Cholecalciferol.Approved
Salicylic acidThe metabolism of Salicylic acid can be decreased when combined with Cholecalciferol.Approved, Vet Approved
SaquinavirThe metabolism of Cholecalciferol can be decreased when combined with Saquinavir.Approved, Investigational
SelegilineThe metabolism of Selegiline can be decreased when combined with Cholecalciferol.Approved, Investigational, Vet Approved
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Cholecalciferol.Approved
SertindoleThe metabolism of Sertindole can be decreased when combined with Cholecalciferol.Approved, Withdrawn
SertralineThe metabolism of Sertraline can be decreased when combined with Cholecalciferol.Approved
SildenafilThe metabolism of Cholecalciferol can be decreased when combined with Sildenafil.Approved, Investigational
SiltuximabThe serum concentration of Cholecalciferol can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Cholecalciferol can be increased when it is combined with Simeprevir.Approved
SimvastatinThe metabolism of Simvastatin can be decreased when combined with Cholecalciferol.Approved
SitaxentanThe metabolism of Sitaxentan can be decreased when combined with Cholecalciferol.Approved, Investigational, Withdrawn
SparteineThe metabolism of Sparteine can be decreased when combined with Cholecalciferol.Experimental
St. John's WortThe serum concentration of Cholecalciferol can be decreased when it is combined with St. John's Wort.Nutraceutical
StiripentolThe serum concentration of Cholecalciferol can be increased when it is combined with Stiripentol.Approved
SucralfateThe serum concentration of Sucralfate can be increased when it is combined with Cholecalciferol.Approved
SulfadiazineThe metabolism of Sulfadiazine can be decreased when combined with Cholecalciferol.Approved, Vet Approved
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be decreased when combined with Cholecalciferol.Approved
SulfamoxoleThe metabolism of Sulfamoxole can be decreased when combined with Cholecalciferol.Approved
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be decreased when combined with Cholecalciferol.Approved
SulfisoxazoleThe metabolism of Cholecalciferol can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
SuprofenThe metabolism of Suprofen can be decreased when combined with Cholecalciferol.Approved, Withdrawn
TamoxifenThe serum concentration of the active metabolites of Tamoxifen can be reduced when Tamoxifen is used in combination with Cholecalciferol resulting in a loss in efficacy.Approved
TamsulosinThe metabolism of Tamsulosin can be decreased when combined with Cholecalciferol.Approved, Investigational
TapentadolThe metabolism of Tapentadol can be decreased when combined with Cholecalciferol.Approved
TegaserodThe metabolism of Tegaserod can be decreased when combined with Cholecalciferol.Investigational, Withdrawn
TelaprevirThe metabolism of Cholecalciferol can be decreased when combined with Telaprevir.Withdrawn
TelithromycinThe metabolism of Cholecalciferol can be decreased when combined with Telithromycin.Approved
TemazepamThe metabolism of Temazepam can be decreased when combined with Cholecalciferol.Approved
TeniposideThe metabolism of Teniposide can be decreased when combined with Cholecalciferol.Approved
TenoxicamThe metabolism of Tenoxicam can be decreased when combined with Cholecalciferol.Approved
TerbinafineThe metabolism of Terbinafine can be decreased when combined with Cholecalciferol.Approved, Investigational, Vet Approved
TerfenadineThe metabolism of Terfenadine can be decreased when combined with Cholecalciferol.Withdrawn
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Cholecalciferol.Investigational
TestosteroneThe metabolism of Testosterone can be decreased when combined with Cholecalciferol.Approved, Investigational
TetrabenazineThe metabolism of Tetrabenazine can be decreased when combined with Cholecalciferol.Approved
ThalidomideThe metabolism of Thalidomide can be decreased when combined with Cholecalciferol.Approved, Investigational, Withdrawn
TheophyllineThe metabolism of Theophylline can be decreased when combined with Cholecalciferol.Approved
ThiamylalThe metabolism of Thiamylal can be decreased when combined with Cholecalciferol.Approved, Vet Approved
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Cholecalciferol.Withdrawn
TiclopidineThe metabolism of Cholecalciferol can be decreased when combined with Ticlopidine.Approved
TimololThe metabolism of Timolol can be decreased when combined with Cholecalciferol.Approved
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Cholecalciferol.Approved
TipranavirThe metabolism of Tipranavir can be decreased when combined with Cholecalciferol.Approved, Investigational
TocilizumabThe serum concentration of Cholecalciferol can be decreased when it is combined with Tocilizumab.Approved
TofacitinibThe metabolism of Tofacitinib can be decreased when combined with Cholecalciferol.Approved, Investigational
TolbutamideThe metabolism of Tolbutamide can be decreased when combined with Cholecalciferol.Approved
TolterodineThe metabolism of Tolterodine can be decreased when combined with Cholecalciferol.Approved, Investigational
TorasemideThe metabolism of Torasemide can be decreased when combined with Cholecalciferol.Approved
TrabectedinThe metabolism of Trabectedin can be decreased when combined with Cholecalciferol.Approved, Investigational
TramadolThe therapeutic efficacy of Tramadol can be decreased when used in combination with Cholecalciferol.Approved, Investigational
TrazodoneThe metabolism of Trazodone can be decreased when combined with Cholecalciferol.Approved, Investigational
TreprostinilThe metabolism of Treprostinil can be decreased when combined with Cholecalciferol.Approved, Investigational
TretinoinThe metabolism of Tretinoin can be decreased when combined with Cholecalciferol.Approved, Investigational, Nutraceutical
TrichlormethiazideTrichlormethiazide may increase the hypercalcemic activities of Cholecalciferol.Approved, Vet Approved
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Cholecalciferol.Approved
TrimethoprimThe metabolism of Trimethoprim can be decreased when combined with Cholecalciferol.Approved, Vet Approved
TrimipramineThe metabolism of Trimipramine can be decreased when combined with Cholecalciferol.Approved
TroglitazoneThe metabolism of Troglitazone can be decreased when combined with Cholecalciferol.Withdrawn
UmeclidiniumThe metabolism of Umeclidinium can be decreased when combined with Cholecalciferol.Approved
ValdecoxibThe metabolism of Valdecoxib can be decreased when combined with Cholecalciferol.Investigational, Withdrawn
Valproic AcidThe metabolism of Valproic Acid can be decreased when combined with Cholecalciferol.Approved, Investigational
ValsartanThe metabolism of Valsartan can be decreased when combined with Cholecalciferol.Approved, Investigational
VenlafaxineThe metabolism of Cholecalciferol can be decreased when combined with Venlafaxine.Approved
VerapamilThe metabolism of Cholecalciferol can be decreased when combined with Verapamil.Approved
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Cholecalciferol.Investigational
VilazodoneThe metabolism of Vilazodone can be decreased when combined with Cholecalciferol.Approved
VinblastineThe metabolism of Vinblastine can be decreased when combined with Cholecalciferol.Approved
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Cholecalciferol.Approved, Investigational
VismodegibThe metabolism of Vismodegib can be decreased when combined with Cholecalciferol.Approved
VoriconazoleThe metabolism of Cholecalciferol can be decreased when combined with Voriconazole.Approved, Investigational
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Cholecalciferol.Approved
WarfarinThe metabolism of Warfarin can be decreased when combined with Cholecalciferol.Approved
XimelagatranThe metabolism of Ximelagatran can be decreased when combined with Cholecalciferol.Approved, Investigational, Withdrawn
YohimbineThe metabolism of Yohimbine can be decreased when combined with Cholecalciferol.Approved, Vet Approved
ZafirlukastThe metabolism of Zafirlukast can be decreased when combined with Cholecalciferol.Approved, Investigational
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Cholecalciferol.Approved
ZaltoprofenThe metabolism of Zaltoprofen can be decreased when combined with Cholecalciferol.Approved
ZidovudineThe metabolism of Zidovudine can be decreased when combined with Cholecalciferol.Approved
ZileutonThe metabolism of Zileuton can be decreased when combined with Cholecalciferol.Approved, Investigational, Withdrawn
ZiprasidoneThe metabolism of Cholecalciferol can be decreased when combined with Ziprasidone.Approved
ZolpidemThe metabolism of Zolpidem can be decreased when combined with Cholecalciferol.Approved
ZopicloneThe metabolism of Zopiclone can be decreased when combined with Cholecalciferol.Approved
ZuclopenthixolThe metabolism of Zuclopenthixol can be decreased when combined with Cholecalciferol.Approved, Investigational
Food InteractionsNot Available
References
Synthesis Reference

Jean Jolly, Primo Rizzi, Jean Taillardat, "1.alpha.,25.alpha.-Dihydroxy-cholecalciferol and methods for the production thereof." U.S. Patent US4435325, issued May, 1977.

US4435325
General References
  1. Armas LA, Hollis BW, Heaney RP: Vitamin D2 is much less effective than vitamin D3 in humans. J Clin Endocrinol Metab. 2004 Nov;89(11):5387-91. [PubMed:15531486 ]
External Links
ATC CodesM05BB08 — Zoledronic acid, calcium and colecalciferol, sequentialA11CC05 — ColecalciferolM05BB04 — Risedronic acid, calcium and colecalciferol, sequentialM05BB05 — Alendronic acid, calcium and colecalciferol, sequentialM05BB03 — Alendronic acid and colecalciferolM05BX53 — Strontium ranelate and colecalciferolM05BB07 — Risedronic acid and colecalciferol
AHFS Codes
  • 88:16.00
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (123 KB)
Clinical Trials
Clinical Trials
PhaseStatusPurposeConditionsCount
0Active Not RecruitingPreventionDeficiency, Vitamin D1
0CompletedPreventionLong Segment Barrett's Esophagus / Short Segment Barrett's Esophagus1
0CompletedTreatmentChronic Kidney Disease (CKD)1
0RecruitingBasic ScienceStage I-III Colon Cancer / Stage IV Colon Cancer With Resectable Liver Metastases / Stage, Colon Cancer1
0Unknown StatusPreventionDeficiency, Vitamin D / Periodontal Diseases1
1CompletedNot AvailableHealthy Volunteers1
1CompletedNot AvailableHuman Immunodeficiency Virus (HIV) Infections / Infection, Human Immunodeficiency Virus I / Mycobacterium avium complex infection1
1CompletedBasic ScienceHealthy Volunteers1
1CompletedDiagnosticHealthy Volunteers1
1CompletedHealth Services ResearchDeficiency, Vitamin D1
1CompletedPreventionHIV/AIDS1
1CompletedPreventionHealthy, no Evidence of Disease / Skin Cancers1
1CompletedTreatmentAcute and Chronic Inflammation / Autoimmune Diseases / Disorder of Pleura and Pleural Cavity / Disorder of Synovium / Felty's Syndrome / Rheumatoid Arthritis / Rheumatoid Nodules / Sjogren's Syndrome1
1CompletedTreatmentCalcium Deficiency / Deficiency, Vitamin D1
1CompletedTreatmentCancers / Metastases1
1CompletedTreatmentDeficiency, Vitamin D1
1CompletedTreatmentDeficiency, Vitamin D / Disseminated Sclerosis1
1CompletedTreatmentSystemic Lupus Erythematosus (SLE)1
1CompletedTreatmentType 2 Diabetes Mellitus1
1Not Yet RecruitingBasic ScienceAging / Mineral deficiency / Vitamin Deficiency1
1RecruitingTreatmentAdult Women / Estrogen Receptor Positive / Metastatic Breast Cancer (MBC)1
1RecruitingTreatmentPneumonia1
1RecruitingTreatmentSarcopenia1
1, 2Active Not RecruitingTreatmentDeficiency, Vitamin D1
1, 2CompletedPreventionBiomarker Change Linked to Breast Cancer1
1, 2CompletedPreventionCancer, Breast1
1, 2CompletedPreventionPrimary Immune Deficiency Disorders (PIDD)1
1, 2CompletedTreatmentDeficiency, Vitamin D / Spinal Cord Injuries (SCI)1
1, 2CompletedTreatmentHIV Disease1
1, 2CompletedTreatmentSickle Cell Disorders1
1, 2Not Yet RecruitingTreatmentDiabetes, Gestational1
1, 2RecruitingTreatmentCancer, Breast / Ductal Carcinoma In-situ / Invasive Breast Carcinoma1
1, 2RecruitingTreatmentCrohn's Disease (CD) / Deficiency, Vitamin D1
1, 2RecruitingTreatmentDeficiency, Vitamin D1
1, 2SuspendedTreatmentSchizoaffective Disorders / Schizophrenic Disorders1
1, 2Unknown StatusTreatmentGlioblastoma Multiforme1
1, 2WithdrawnTreatmentUlcerative Colitis (UC)1
2Active Not RecruitingPreventionBone Loss / Calcifications, Vascular / End Stage Renal Disease (ESRD) / Fracture Bone / Transplantation, Kidney1
2Active Not RecruitingTreatmentAcute Chest Syndrome / Asthma Bronchial / Deficiency, Vitamin D / Respiratory Tract Infections (RTI) / Sickle Cell Disorders1
2Active Not RecruitingTreatmentBone Diseases / Diabetic Nephropathies / Sub-optimal Vitamin D Status1
2Active Not RecruitingTreatmentCholecalciferol Toxicity / Methicillin Resistant Staphylococcus Aureus (MRSA) / Resistant Staphylococcus Aureus: [Methicillin] or [Multiple] / Staphylococcus Aureus Infections / Vitamin D3 Deficiency1
2CompletedBasic ScienceInsulin Sensitivity / Intraocular Pressure1
2CompletedBasic ScienceProstate Cancer1
2CompletedBasic ScienceType 2 Diabetes Mellitus / Vitamin D Insufficiency1
2CompletedDiagnosticHypersensitivity1
2CompletedPreventionAtherosclerosis / Systemic Lupus Erythematosus (SLE)1
2CompletedPreventionAutistic Disorder1
2CompletedPreventionCancer, Breast1
2CompletedPreventionCancer, Ovarian1
2CompletedPreventionColorectal Cancers1
2CompletedPreventionHuman Immunodeficiency Virus (HIV) Infections1
2CompletedSupportive CareArthralgia / Muscle pains1
2CompletedTreatmentAdenocarcinoma, Prostate / Stage I Prostate Cancer / Stage IIA Prostate Cancer / Stage IIB Prostate Cancer1
2CompletedTreatmentAids / Human Immunodeficiency Virus (HIV) Infections1
2CompletedTreatmentAllergic Rhinoconjunctivitis1
2CompletedTreatmentAutism, Early Infantile1
2CompletedTreatmentBMI >30 kg/m21
2CompletedTreatmentCancer, Breast1
2CompletedTreatmentChronic Heart Failure (CHF)1
2CompletedTreatmentChronic Kidney Disease (CKD)1
2CompletedTreatmentCongestive Heart Failure (CHF) / Deficiency, Vitamin D / Heart Failure, Unspecified / Prophylaxis of cardiomyopathy1
2CompletedTreatmentCrohn's Disease (CD)1
2CompletedTreatmentDeficiency, Vitamin D / HIV Disease / Hyperparathyroidism / Hypovitaminosis D1
2CompletedTreatmentDeficiency, Vitamin D / Hypertensive1
2CompletedTreatmentEnd-Stage Renal Disease (ESRD)1
2CompletedTreatmentFalls, Accidental / Parkinson's Disease (PD)1
2CompletedTreatmentGaucher's Disease / Osteopenia1
2CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections1
2CompletedTreatmentInfection, Human Immunodeficiency Virus I1
2CompletedTreatmentLupus / Systemic Lupus Erythematosus (SLE)1
2CompletedTreatmentNon-Alcoholic Steatohepatitis (NASH)1
2CompletedTreatmentPolycystic Ovarian Syndrome / Reproductive Endocrinology1
2CompletedTreatmentBone destruction / Postmenopausal Osteoporosis (PMO)1
2CompletedTreatmentProstate Cancer2
2CompletedTreatmentModerate, refractory Atopic dermatitis / Psoriasis1
2CompletedTreatmentPulmonary Tuberculosis (TB)1
2CompletedTreatmentType 2 Diabetes Mellitus1
2Enrolling by InvitationBasic SciencePulmonary Disease, Chronic Obstructive1
2Enrolling by InvitationPreventionDiabetes, Diabetes Mellitus Type 1 / Prediabetic State1
2Enrolling by InvitationTreatmentDeficiency, Vitamin D / Diabetes Mellitus (DM) / Hypertensive / Lipid Metabolism Disorders / Obesity, Abdominal1
2Not Yet RecruitingPreventionDeficiency, Vitamin D / Hypertensive1
2Not Yet RecruitingPreventionNeurofibromatosis Type 1 (NF1)1
2Not Yet RecruitingTreatmentDeficiency, Vitamin D1
2RecruitingBasic ScienceDeficiency, Vitamin D1
2RecruitingOtherFracture Bone1
2RecruitingPreventionDeficiency, Vitamin D / Peritoneal Dialysis-associated Peritonitis1
2RecruitingPreventionBone destruction / Osteopenia1
2RecruitingTreatmentAcute Myeloid Leukaemias (AML)1
2RecruitingTreatmentAsthma Bronchial1
2RecruitingTreatmentBone Metabolism Biomarkers / Bone Mineral Density / Physical Fitness1
2RecruitingTreatmentDepressive State / Diabetes / Quality of Life1
2RecruitingTreatmentDiabetes / Executive Dysfunction1
2RecruitingTreatmentHuman Immunodeficiency Virus (HIV) Infections1
2RecruitingTreatmentHypovitaminosis D1
2RecruitingTreatmentProstate Cancer1
2RecruitingTreatmentTuberculosis1
2RecruitingTreatmentModerate, refractory Atopic dermatitis1
2TerminatedOtherDisseminated Sclerosis1
2TerminatedSupportive CareNeurotoxicity1
2TerminatedTreatmentSystemic Lupus Erythematosus (SLE)1
2Unknown StatusPreventionCancer, Breast1
2Unknown StatusPreventionSickle Cell Disorders1
2Unknown StatusTreatmentAnemia of Chronic Kidney Disease1
2Unknown StatusTreatmentBMI >30 kg/m2 / Bypass, Gastric / Gastric Resection1
2Unknown StatusTreatmentBMI >30 kg/m2 / Deficiency, Vitamin D / Insulin Resistance1
2Unknown StatusTreatmentDeficiency, Vitamin D1
2Unknown StatusTreatmentDeficiency, Vitamin D / Human Immunodeficiency Virus (HIV) Infections1
2Unknown StatusTreatmentHypovitaminosis D / Type 2 Diabetes Mellitus1
2WithdrawnBasic ScienceBMI >30 kg/m21
2WithdrawnTreatmentDeficiency, Vitamin D / Rheumatoid Arthritis1
2WithdrawnTreatmentSchizoaffective Disorders / Schizophrenic Disorders1
2, 3Active Not RecruitingPreventionAdenoma benign / Colorectal Cancers / Polyps1
2, 3CompletedPreventionImpaired Glucose Tolerance (IGT)1
2, 3CompletedTreatmentCardiovascular Disease (CVD) / Chronic Kidney Disease (CKD) / Mortality1
2, 3CompletedTreatmentDeficiency, Vitamin D / Hypercalcemia / Hyperparathyroidism, Primary1
2, 3CompletedTreatmentDisseminated Sclerosis1
2, 3CompletedTreatmentHIV+ / Human Immunodeficiency Virus (HIV) Infections1
2, 3CompletedTreatmentMale Infertility1
2, 3CompletedTreatmentType 2 Diabetes Mellitus1
2, 3Not Yet RecruitingPreventionCritical Illness / Deficiency, Vitamin D1
2, 3RecruitingTreatmentAllergies1
2, 3RecruitingTreatmentCraniocerebral Trauma / Critical Illness / Deficiency, Vitamin D / Intracranial Aneurysms / Intracranial Hemorrhages / Meningitis / Neoplasms, Brain / Seizures / Spinal Cord Injuries (SCI) / Strokes1
2, 3TerminatedTreatmentCancer, Breast / Musculoskeletal Disorders1
2, 3Unknown StatusTreatmentDeficiency, Vitamin D / Heart Failure, Unspecified1
3Active Not RecruitingPreventionImprove Healthy Ageing in Seniors; Prevent Disease at Older Age1
3Active Not RecruitingPreventionType 2 Diabetes Mellitus1
3Active Not RecruitingTreatmentCutaneous Malignant Melanoma1
3Active Not RecruitingTreatmentLocally Advanced Breast Cancer and Large Operable Breast Cancer1
3CompletedHealth Services ResearchDeficiency, Vitamin D1
3CompletedPreventionAcute Bronchiolitis / Acute Tracheobronchitis / Upper Respiratory Tract Infections1
3CompletedPreventionDeficiency, Vitamin D2
3CompletedPreventionDeficiency, Vitamin D / Pregnancy1
3CompletedTreatmentAlzheimer's Disease (AD)1
3CompletedTreatmentAnemias1
3CompletedTreatmentAsthma Bronchial2
3CompletedTreatmentBypass, Gastric / Parathyroid Hormone1
3CompletedTreatmentCKd Patients With Stage 3 and 41
3CompletedTreatmentCancer, Breast1
3CompletedTreatmentChronic Hepatitis C Infection1
3CompletedTreatmentChronic Kidney Disease Stage 3 and 41
3CompletedTreatmentChronic Renal Insufficiency / Deficiency, Vitamin D1
3CompletedTreatmentCritical Illness / Deficiency, Vitamin D1
3CompletedTreatmentDeficiency, Vitamin D3
3CompletedTreatmentDeficiency, Vitamin D / Heart Failure, Unspecified1
3CompletedTreatmentDiabetes / Insulin Resistance / Low-intensity Chronic Inflammation1
3CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Tuberculosis, Pulmonary1
3CompletedTreatmentHypovitaminosis D1
3CompletedTreatmentHypovitaminosis D / Polycystic Ovaries Syndrome1
3CompletedTreatmentInfection NOS1
3CompletedTreatmentPlaque Psoriasis1
3CompletedTreatmentTuberculosis, Pulmonary1
3CompletedTreatmentBone destruction1
3Not Yet RecruitingPreventionEnd Organ Damage / Multiple Organ Failure / Sepsis / Severe Sepsis1
3Not Yet RecruitingTreatmentCritical Illness / Deficiency, Vitamin D1
3Not Yet RecruitingTreatmentCritical Illness / Deficiency, Vitamin D / Sarcopenia1
3Not Yet RecruitingTreatmentCrohn's Disease (CD) / Inflammatory Bowel Diseases (IBD) / Ulcerative Colitis (UC)1
3RecruitingPreventionCancers / Cardiovascular Disease (CVD) / Fracture Bone1
3RecruitingPreventionDisseminated Sclerosis1
3RecruitingTreatmentAcute Respiratory Distress Syndrome (ARDS) / Critical Illness / Deficiency, Vitamin D1
3RecruitingTreatmentCrohn's Disease (CD)1
3RecruitingTreatmentDeficiency, Vitamin D1
3RecruitingTreatmentDyslipidemias1
3RecruitingTreatmentH. Pylori Infection1
3RecruitingTreatmentHypogonadism / Pre-frail Seniors1
3RecruitingTreatmentMelanoma1
3RecruitingTreatmentOsteopenia1
3RecruitingTreatmentRelapsing Remitting Multiple Sclerosis (RRMS)1
3RecruitingTreatmentUrticarias1
3TerminatedPreventionPolymorphic Light Eruption (PLE)1
3TerminatedTreatmentDeficiency, Vitamin D / Diabetes Mellitus (DM)1
3Unknown StatusNot AvailableAnemias / Low Birth Weight / Neonatal Mortality1
3Unknown StatusPreventionFalls, Accidental / Fracture Bone / Hip Fractures1
3Unknown StatusTreatmentAlzheimer's Disease (AD) / Down Syndrome (DS)1
3Unknown StatusTreatmentChronic Lymphocytic Leukaemia (CLL)1
3Unknown StatusTreatmentDeficiency, Vitamin D / Renal Osteodystrophy / Transplantation, Kidney1
3Unknown StatusTreatmentHypovitaminosis D1
3Unknown StatusTreatmentTuberculosis1
3Unknown StatusTreatment[X]Statin Causing Adverse Effect in Therapeutic Use1
4Active Not RecruitingPreventionAllergies / Wheezing1
4Active Not RecruitingPreventionHypocalcemia1
4Active Not RecruitingTreatmentAsthma Bronchial1
4Active Not RecruitingTreatmentCalcifications, Vascular / Deficiency, Vitamin D / End Stage Renal Failure on Dialysis / Impaired Renal Function1
4CompletedBasic ScienceDeficiency, Vitamin D2
4CompletedBasic SciencePremature Births1
4CompletedPreventionDeficiency, Vitamin D1
4CompletedPreventionDiabetes, Diabetes Mellitus Type 12
4CompletedPreventionHealthy Humans1
4CompletedPreventionImmune Tolerance1
4CompletedPreventionRecurrent Respiratory Tract Infections1
4CompletedTreatmentAnovulatory cycle / Polycystic Ovaries Syndrome1
4CompletedTreatmentBMI >30 kg/m2 / Deficiency, Vitamin D2
4CompletedTreatmentBariatric Surgery Candidate1
4CompletedTreatmentCardiorenal Syndrome / Chronic Allograft Nephropathy (CAN)1
4CompletedTreatmentDeficiency, Vitamin D2
4CompletedTreatmentDeficiency, Vitamin D / Glucose tolerance impaired / Type 2 Diabetes Mellitus1
4CompletedTreatmentDeficiency, Vitamin D / Polycystic Ovaries Syndrome1
4CompletedTreatmentDiabetes Mellitus (DM)1
4CompletedTreatmentEnd Stage Kidney Disease1
4CompletedTreatmentEpilepsies1
4CompletedTreatmentHyperemesis Gravidarum / Morning Sickness / Nausea / Pregnancy / Vomiting1
4CompletedTreatmentBone destruction / Osteopenia1
4CompletedTreatmentPancreatitis, Chronic1
4CompletedTreatmentPneumonia1
4CompletedTreatmentPostmenopausal Osteoporosis (PMO)1
4CompletedTreatmentPregnancy1
4CompletedTreatmentSeasonal Allergic Rhinitis (SAR)1
4Not Yet RecruitingPreventionHepatocellular,Carcinoma / Viral Hepatitis B1
4Not Yet RecruitingTreatmentVitamin D Substitution1
4RecruitingBasic Science25-Hydroxyvitamin D Concentration / Deficiency, Vitamin D1
4RecruitingPreventionBenign Paroxysmal Positional Vertigo (BPPV)1
4RecruitingPreventionEclampsia / Gestational Hypertension / HELLP Syndrome / Superimposed Preeclampsia / Toxemia1
4RecruitingPreventionFood Allergy1
4RecruitingTreatmentBone Diseases, Metabolic / Renal Insufficiency,Chronic / Vascular Stiffness1
4RecruitingTreatmentBronchiectasis1
4RecruitingTreatmentCerebral Vascular Accident (CVA) / Heart Failure Hospitalization / Mortality / Myocardial Infarction (MI)1
4RecruitingTreatmentDeficiency, Vitamin D1
4RecruitingTreatmentDiabetes, Diabetes Mellitus Type 11
4RecruitingTreatmentHuman Immunodeficiency Virus (HIV) Infections1
4TerminatedTreatmentCrohn's Disease (CD) / Deficiency, Vitamin D1
4TerminatedTreatmentHeart Failure, Unspecified1
4TerminatedTreatmentPeripheral Arterial Disease (PAD)1
4Unknown StatusDiagnosticThalassemia Major (TM)1
4Unknown StatusTreatmentAcute Lower Respiratory Tract Infection / Bronchiolitis / Pneumonia1
4Unknown StatusTreatmentBMI >30 kg/m2 / Deficiency, Vitamin D / Hyperparathyroidism, Secondary1
4Unknown StatusTreatmentBMI >30 kg/m2 / Insulin Resistance1
4Unknown StatusTreatmentDisseminated Sclerosis1
4Unknown StatusTreatmentMetabolic Syndromes1
4Unknown StatusTreatmentPersistent Asthma1
4Unknown StatusTreatmentBone destruction1
4WithdrawnTreatmentCrohn's Disease (CD)1
4WithdrawnTreatmentNephritis / Proteinuria / Systemic Lupus Erythematosus (SLE)1
Not AvailableActive Not RecruitingPreventionHypovitaminosis D1
Not AvailableActive Not RecruitingSupportive CareHyperparathyroidism, Primary1
Not AvailableActive Not RecruitingTreatmentAsthma Bronchial / Deficiency, Vitamin D1
Not AvailableActive Not RecruitingTreatmentDeficiency, Vitamin D1
Not AvailableCompletedNot AvailableDeficiency, Vitamin D1
Not AvailableCompletedNot AvailableDiabetes, Diabetes Mellitus Type 11
Not AvailableCompletedNot AvailableHMG COA Reductase Inhibitor Adverse Reaction1
Not AvailableCompletedNot AvailableHuman Immunodeficiency Virus (HIV) Infections1
Not AvailableCompletedNot AvailableBone destruction1
Not AvailableCompletedOtherType 2 Diabetes Mellitus1
Not AvailableCompletedPreventionBlood Platelet Disorders / Deficiency, Vitamin D1
Not AvailableCompletedPreventionCancer, Breast2
Not AvailableCompletedPreventionDeficiency, Vitamin D1
Not AvailableCompletedPreventionGingival Inflammation1
Not AvailableCompletedPreventionMalignant Melanoma of Skin1
Not AvailableCompletedPreventionNeural Tube Defects (NTDs)1
Not AvailableCompletedPreventionSarcopenia1
Not AvailableCompletedPreventionBone destruction2
Not AvailableCompletedSupportive CareBurn Injuries / Vitamin D1
Not AvailableCompletedSupportive CareDiabetic Neuropathies1
Not AvailableCompletedSupportive CareTuberculosis, Pulmonary1
Not AvailableCompletedTreatmentAngioedema / Hives / Swelling / Urticarias1
Not AvailableCompletedTreatmentArterial Dysfunction / Chronic Kidney Disease (CKD)1
Not AvailableCompletedTreatmentAsthma Bronchial / Deficiency, Vitamin D / Disease Exacerbation1
Not AvailableCompletedTreatmentBipolar Disorder (BD) / Depression, Bipolar1
Not AvailableCompletedTreatmentChronic Kidney Disease (CKD) / Deficiency, Vitamin D1
Not AvailableCompletedTreatmentChronic Kidney Disease (CKD) / Deficiency, Vitamin D / Insulin Resistance1
Not AvailableCompletedTreatmentChronic Kidney Disease (CKD) / End-Stage Renal Disease (ESRD)1
Not AvailableCompletedTreatmentClozapine Resistant Schizophrenia1
Not AvailableCompletedTreatmentCystic Fibrosis (CF)1
Not AvailableCompletedTreatmentBone destruction / Cystic Fibrosis (CF)1
Not AvailableCompletedTreatmentDeficiency of Vitamin D3 / Gingival and Periodontal Disease / Pregnancy1
Not AvailableCompletedTreatmentDeficiency, Vitamin D4
Not AvailableCompletedTreatmentDeficiency, Vitamin D / End-Stage Renal Disease (ESRD)1
Not AvailableCompletedTreatmentDeficiency, Vitamin D / Hypertensive / Pre-Hypertension1
Not AvailableCompletedTreatmentDeficiency, Vitamin D / Renal Failure Chronic Requiring Hemodialysis1
Not AvailableCompletedTreatmentEnd-Stage Renal Disease (ESRD)2
Not AvailableCompletedTreatmentEndometriosis1
Not AvailableCompletedTreatmentHeart Failure, Unspecified1
Not AvailableCompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections1
Not AvailableCompletedTreatmentHyperparathyroidism, Secondary / Renal Insufficiency,Chronic1
Not AvailableCompletedTreatmentIntestinal Malabsorption / Pancreatitis, Chronic1
Not AvailableCompletedTreatmentPolycystic Ovaries Syndrome1
Not AvailableCompletedTreatmentRenal Osteodystrophy / Secondary Hyperparathyroidism in Chronic Kidney Disease Stage 3 and 41
Not AvailableCompletedTreatmentSystemic Lupus Erythematosus (SLE)1
Not AvailableNot Yet RecruitingPreventionTransient Hypercalciuria1
Not AvailableNot Yet RecruitingTreatmentBreast Cancer Metastatic / Metastatic Breast Cancer (MBC)1
Not AvailableRecruitingTreatmentAtherosclerosis / Leukocyte Activation Disorder / Oxidative Stress1
Not AvailableRecruitingTreatmentBMI >30 kg/m21
Not AvailableRecruitingTreatmentCancer, Breast1
Not AvailableRecruitingTreatmentCancer, Ovarian1
Not AvailableRecruitingTreatmentCardiovascular Disease (CVD) / Deficiency, Vitamin D / Hypertensive / Insulin Resistance / Type 2 Diabetes Mellitus1
Not AvailableRecruitingTreatmentNeoplasms, Brain1
Not AvailableRecruitingTreatmentProphylaxis of Contrast-induced nephropathy1
Not AvailableTerminatedNot AvailableUrolithiasis1
Not AvailableTerminatedBasic ScienceCancer, Breast1
Not AvailableTerminatedTreatmentHMG-CoA Reductase Inhibitors-related Myalgias1
Not AvailableUnknown StatusTreatmentChronic Musculoskeletal Pain / Vitamin D Supplementation1
Not AvailableUnknown StatusTreatmentChronic Rhinosinusitis1
Not AvailableUnknown StatusTreatmentDeficiency, Vitamin D / Hepatocellular,Carcinoma1
Not AvailableUnknown StatusTreatmentDiabetic Kidney Disease1
Not AvailableUnknown StatusTreatmentHypercholesterolemia, Familial1
Not AvailableWithdrawnTreatmentHMG COA Reductase Inhibitor Adverse Reaction1
Not AvailableWithdrawnTreatmentInflammatory Bowel Diseases (IBD) / Ulcerative Colitis (UC)1
Not AvailableWithdrawnTreatmentTuberculosis1
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
OintmentTopical
Granule, effervescent; kit; tabletOral
CreamTopical
WaferOral
Kit
Solution / dropsOral400 unit
TabletOral10000 unit
LiquidOral
WaferOral100 unit
TabletOral
PowderOral
CapsuleOral2000 unit
CapsuleOral25000 unit
Solution / dropsOral
SolutionOral
CapsuleOral
Tablet, film coatedOral
Injection, solutionIntravenous
CapsuleOral10000 unit
CapsuleOral5000 unit
CapsuleOral50000 unit
Tablet, coatedOral
Capsule, liquid filledOral
Tablet, chewableOral
Tablet, effervescentOral
Capsule, gelatin coatedOral
TabletOral1000 unit
TabletOral400 unit
CapsuleOral100000 unit
Prices
Unit descriptionCostUnit
Cholecalciferol crystals104.3USD g
Vitamin d3 2400 unit/ml liquid0.8USD ml
Vitamin d3 2000 unit spray0.44USD ml
Vitamin d3 3000 unit tablet0.11USD tablet
Vitamin d-3 2000 unit tablet0.07USD tablet
CVS Pharmacy vitamin d 1000 unit tablet0.04USD tablet
Delta d3 400 unit tablet0.04USD each
Vitamin d 1000 unit tablet0.03USD tablet
Pv vitamin d 2000 unit tablet0.02USD tablet
Pv vitamin d 5000 unit tablet0.02USD tablet
Vitamin d 400 unit tablet0.02USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US5994329 Yes1999-01-172019-01-17Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point (°C)84.5 °CPhysProp
water solubilityInsolubleNot Available
logP7.5Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00038 mg/mLALOGPS
logP7.98ALOGPS
logP7.13ChemAxon
logS-6ALOGPS
pKa (Strongest Acidic)18.38ChemAxon
pKa (Strongest Basic)-1.3ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count1ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area20.23 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity123.22 m3·mol-1ChemAxon
Polarizability49.6 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+1.0
Blood Brain Barrier+0.959
Caco-2 permeable+0.8342
P-glycoprotein substrateSubstrate0.6706
P-glycoprotein inhibitor IInhibitor0.7603
P-glycoprotein inhibitor IINon-inhibitor0.5346
Renal organic cation transporterNon-inhibitor0.7818
CYP450 2C9 substrateNon-substrate0.8384
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateSubstrate0.7302
CYP450 1A2 substrateNon-inhibitor0.9256
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorNon-inhibitor0.9551
CYP450 2C19 inhibitorNon-inhibitor0.9026
CYP450 3A4 inhibitorNon-inhibitor0.7881
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.7093
Ames testNon AMES toxic0.9132
CarcinogenicityNon-carcinogens0.921
BiodegradationNot ready biodegradable0.9878
Rat acute toxicity3.9310 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.773
hERG inhibition (predictor II)Non-inhibitor0.7589
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Spectra
Mass Spec (NIST)Download (11.1 KB)
Spectra
Spectrum TypeDescriptionSplash Key
Predicted GC-MSPredicted GC-MS Spectrum - GC-MSNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as vitamin d and derivatives. These are compounds containing a secosteroid backbone, usually secoergostane or secocholestane.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassSteroids and steroid derivatives
Sub ClassVitamin D and derivatives
Direct ParentVitamin D and derivatives
Alternative ParentsTriterpenoids / Secondary alcohols / Cyclic alcohols and derivatives / Hydrocarbon derivatives
SubstituentsTriterpenoid / Cyclic alcohol / Secondary alcohol / Organic oxygen compound / Hydrocarbon derivative / Organooxygen compound / Alcohol / Aliphatic homopolycyclic compound
Molecular FrameworkAliphatic homopolycyclic compounds
External Descriptorssecondary alcohol, steroid hormone, seco-cholestane, hydroxy seco-steroid, D3 vitamins (CHEBI:28940 ) / Vitamin D3 and derivatives, Fat-soluble vitamins (C05443 ) / Vitamin D3 and derivatives (LMST03020000 )

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Zinc ion binding
Specific Function:
Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Recruited to promoters via its interaction with BAZ1B/WSTF which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.
Gene Name:
VDR
Uniprot ID:
P11473
Uniprot Name:
Vitamin D3 receptor
Molecular Weight:
48288.64 Da
References
  1. Reinhart GA: Vitamin D analogs: novel therapeutic agents for cardiovascular disease? Curr Opin Investig Drugs. 2004 Sep;5(9):947-51. [PubMed:15503649 ]
  2. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  3. Fujishima T, Tsuji G, Tanaka C, Harayama H: Novel vitamin D receptor ligands having a carboxyl group as an anchor to arginine 274 in the ligand-binding domain. J Steroid Biochem Mol Biol. 2010 Jul;121(1-2):60-2. doi: 10.1016/j.jsbmb.2010.04.020. Epub 2010 May 6. [PubMed:20435140 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3).
Gene Name:
CYP2R1
Uniprot ID:
Q6VVX0
Uniprot Name:
Vitamin D 25-hydroxylase
Molecular Weight:
57358.82 Da
References
  1. Flanagan JN, Young MV, Persons KS, Wang L, Mathieu JS, Whitlatch LW, Holick MF, Chen TC: Vitamin D metabolism in human prostate cells: implications for prostate cancer chemoprevention by vitamin D. Anticancer Res. 2006 Jul-Aug;26(4A):2567-72. [PubMed:16886665 ]
  2. Segura-Aguilar J: Peroxidase activity of liver microsomal vitamin D 25-hydroxylase and cytochrome P450 1A2 catalyzes 25-hydroxylation of vitamin D3 and oxidation of dopamine to aminochrome. Biochem Mol Med. 1996 Jun;58(1):122-9. [PubMed:8809353 ]
  3. Schuster I: Cytochromes P450 are essential players in the vitamin D signaling system. Biochim Biophys Acta. 2011 Jan;1814(1):186-99. doi: 10.1016/j.bbapap.2010.06.022. Epub 2010 Jul 7. [PubMed:20619365 ]
  4. Ohyama Y, Yamasaki T: Eight cytochrome P450s catalyze vitamin D metabolism. Front Biosci. 2004 Sep 1;9:3007-18. [PubMed:15353333 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Catalyzes the first step in the oxidation of the side chain of sterol intermediates; the 27-hydroxylation of 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol. Has also a vitamin D3-25-hydroxylase activity.
Gene Name:
CYP27A1
Uniprot ID:
Q02318
Uniprot Name:
Sterol 26-hydroxylase, mitochondrial
Molecular Weight:
60234.28 Da
References
  1. Lehmann B, Tiebel O, Meurer M: Expression of vitamin D3 25-hydroxylase (CYP27) mRNA after induction by vitamin D3 or UVB radiation in keratinocytes of human skin equivalents--a preliminary study. Arch Dermatol Res. 1999 Sep;291(9):507-10. [PubMed:10541881 ]
  2. Sawada N, Sakaki T, Yoneda S, Kusudo T, Shinkyo R, Ohta M, Inouye K: Conversion of vitamin D3 to 1alpha,25-dihydroxyvitamin D3 by Streptomyces griseolus cytochrome P450SU-1. Biochem Biophys Res Commun. 2004 Jul 16;320(1):156-64. [PubMed:15207715 ]
  3. Uchida E, Kagawa N, Sakaki T, Urushino N, Sawada N, Kamakura M, Ohta M, Kato S, Inouye K: Purification and characterization of mouse CYP27B1 overproduced by an Escherichia coli system coexpressing molecular chaperonins GroEL/ES. Biochem Biophys Res Commun. 2004 Oct 15;323(2):505-11. [PubMed:15369780 ]
  4. Sakaki T, Kagawa N, Yamamoto K, Inouye K: Metabolism of vitamin D3 by cytochromes P450. Front Biosci. 2005 Jan 1;10:119-34. Print 2005 Jan 1. [PubMed:15574355 ]
  5. Tokar EJ, Webber MM: Cholecalciferol (vitamin D3) inhibits growth and invasion by up-regulating nuclear receptors and 25-hydroxylase (CYP27A1) in human prostate cancer cells. Clin Exp Metastasis. 2005;22(3):275-84. [PubMed:16158255 ]
  6. Schuster I: Cytochromes P450 are essential players in the vitamin D signaling system. Biochim Biophys Acta. 2011 Jan;1814(1):186-99. doi: 10.1016/j.bbapap.2010.06.022. Epub 2010 Jul 7. [PubMed:20619365 ]
  7. Ohyama Y, Yamasaki T: Eight cytochrome P450s catalyze vitamin D metabolism. Front Biosci. 2004 Sep 1;9:3007-18. [PubMed:15353333 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation to all four regioisomeric cis-epoxyeicosatrienoic acids. One of the predominant enzymes responsible for the epoxidation of endogenous cardiac arachidonic acid pools.
Gene Name:
CYP2J2
Uniprot ID:
P51589
Uniprot Name:
Cytochrome P450 2J2
Molecular Weight:
57610.165 Da
References
  1. Aiba I, Yamasaki T, Shinki T, Izumi S, Yamamoto K, Yamada S, Terato H, Ide H, Ohyama Y: Characterization of rat and human CYP2J enzymes as Vitamin D 25-hydroxylases. Steroids. 2006 Oct;71(10):849-56. Epub 2006 Jul 13. [PubMed:16842832 ]
  2. Schuster I: Cytochromes P450 are essential players in the vitamin D signaling system. Biochim Biophys Acta. 2011 Jan;1814(1):186-99. doi: 10.1016/j.bbapap.2010.06.022. Epub 2010 Jul 7. [PubMed:20619365 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Uniprot Name:
Cytochrome P450 3A4
Molecular Weight:
57342.67 Da
References
  1. Schuster I: Cytochromes P450 are essential players in the vitamin D signaling system. Biochim Biophys Acta. 2011 Jan;1814(1):186-99. doi: 10.1016/j.bbapap.2010.06.022. Epub 2010 Jul 7. [PubMed:20619365 ]
  2. Ohyama Y, Yamasaki T: Eight cytochrome P450s catalyze vitamin D metabolism. Front Biosci. 2004 Sep 1;9:3007-18. [PubMed:15353333 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, nad(p)h as one donor, and incorporation of one atom of oxygen
Specific Function:
Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.
Gene Name:
CYP11A1
Uniprot ID:
P05108
Uniprot Name:
Cholesterol side-chain cleavage enzyme, mitochondrial
Molecular Weight:
60101.87 Da
References
  1. Tuckey RC, Janjetovic Z, Li W, Nguyen MN, Zmijewski MA, Zjawiony J, Slominski A: Metabolism of 1alpha-hydroxyvitamin D3 by cytochrome P450scc to biologically active 1alpha,20-dihydroxyvitamin D3. J Steroid Biochem Mol Biol. 2008 Dec;112(4-5):213-9. doi: 10.1016/j.jsbmb.2008.10.005. Epub 2008 Oct 21. [PubMed:19000766 ]
  2. Tuckey RC, Nguyen MN, Slominski A: Kinetics of vitamin D3 metabolism by cytochrome P450scc (CYP11A1) in phospholipid vesicles and cyclodextrin. Int J Biochem Cell Biol. 2008;40(11):2619-26. doi: 10.1016/j.biocel.2008.05.006. Epub 2008 May 20. [PubMed:18573681 ]
  3. Guryev O, Carvalho RA, Usanov S, Gilep A, Estabrook RW: A pathway for the metabolism of vitamin D3: unique hydroxylated metabolites formed during catalysis with cytochrome P450scc (CYP11A1). Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14754-9. Epub 2003 Dec 1. [PubMed:14657394 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Vitamin d 24-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP1A1
Uniprot ID:
P04798
Uniprot Name:
Cytochrome P450 1A1
Molecular Weight:
58164.815 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Gene Name:
CYP2B6
Uniprot ID:
P20813
Uniprot Name:
Cytochrome P450 2B6
Molecular Weight:
56277.81 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Uniprot Name:
Cytochrome P450 2C19
Molecular Weight:
55930.545 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme...
Gene Name:
CYP2C8
Uniprot ID:
P10632
Uniprot Name:
Cytochrome P450 2C8
Molecular Weight:
55824.275 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Uniprot Name:
Cytochrome P450 2C9
Molecular Weight:
55627.365 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Uniprot Name:
Cytochrome P450 2D6
Molecular Weight:
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Carriers

Kind
Protein
Organism
Human
Pharmacological action
no
General Function:
Vitamin transporter activity
Specific Function:
Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.
Gene Name:
GC
Uniprot ID:
P02774
Uniprot Name:
Vitamin D-binding protein
Molecular Weight:
52963.025 Da
References
  1. Nykjaer A, Dragun D, Walther D, Vorum H, Jacobsen C, Herz J, Melsen F, Christensen EI, Willnow TE: An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3. Cell. 1999 Feb 19;96(4):507-15. [PubMed:10052453 ]
  2. Verboven C, Rabijns A, De Maeyer M, Van Baelen H, Bouillon R, De Ranter C: A structural basis for the unique binding features of the human vitamin D-binding protein. Nat Struct Biol. 2002 Feb;9(2):131-6. [PubMed:11799400 ]
  3. Houghton LA, Vieth R: The case against ergocalciferol (vitamin D2) as a vitamin supplement. Am J Clin Nutr. 2006 Oct;84(4):694-7. [PubMed:17023693 ]
  4. Yamamoto N, Naraparaju VR: Vitamin D3-binding protein as a precursor for macrophage activating factor in the inflammation-primed macrophage activation cascade in rats. Cell Immunol. 1996 Jun 15;170(2):161-7. [PubMed:8660814 ]
  5. Yamamoto N, Naraparaju VR: Role of vitamin D3-binding protein in activation of mouse macrophages. J Immunol. 1996 Aug 15;157(4):1744-9. [PubMed:8759764 ]
Drug created on June 13, 2005 07:24 / Updated on September 01, 2017 10:24