Centrally Acting Sympathomimetics

DrugDrug NameDrug Indication
DB00182AmphetamineFor treatment of Attention Deficit Disorder with Hyperactivity (ADDH), narcolepsy, and exogenous obesity as a short term (a few weeks) adjunct in a regimen of weight reduction based on caloric restriction for patients refractory to alternative therapy.
DB00289AtomoxetineFor the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) alone or in combination with behavioral treatment, as an adjunct to psychological, educational, social, and other remedial measures.
DB00422MethylphenidateFor use as an integral part of a total treatment program which typically includes other remedial measures (psychological, educational, social) for a stabilizing effect in children with a behavioral syndrome characterized by the following group of developmentally inappropriate symptoms: moderate-to-severe distractibility, short attention span, hyperactivity, emotional lability, and impulsivity.
DB00745ModafinilTo improve wakefulness in patients with excessive daytime sleepiness (EDS) associated with narcolepsy.
DB01230PemolineFor treatment of Attention Deficit Hyperactivity Disorder (ADHD)
DB01255LisdexamfetamineFor the treatment of Attention Deficit/Hyperactivity Disorder (ADHD) in pediatric populations aged 6 to 12 years.
DB01463FencamfamineFor the the treatment of depressive fatigue in convalescence and other debilitated states as well as in the treatment of depressive day-time fatigue, lack of concentration and lethargy.
DB01576DextroamphetamineUsed to treat attention deficit hyperactivity disorder (ADHD).
DB01577MethamphetamineFor the treatment of Attention Deficit Disorder with Hyperactivity (ADHD) and exogenous obesity.
DB06413ArmodafinilInvestigated for use/treatment in sleep disorders, obstructive sleep apnea, schizophrenia and schizoaffective disorders, depression, and bipolar disorders.
DB06701DexmethylphenidateDexmethylphenidate is used as a treatment for ADHD, ideally in conjunction with psychological, educational, behavioral or other forms of treatment.
DB01482FenethyllineNot Available
DrugDrug NameTargetType
DB00182AmphetamineCytochrome P450 2D6enzyme
DB00182AmphetamineCytochrome P450 2A6enzyme
DB00182AmphetamineSodium-dependent dopamine transportertarget
DB00182AmphetamineCocaine- and amphetamine-regulated transcript proteintarget
DB00182AmphetamineTrace amine-associated receptor 1target
DB00182AmphetamineSynaptic vesicular amine transportertarget
DB00182AmphetamineSodium-dependent noradrenaline transportertarget
DB00182AmphetamineAlpha adrenergic receptortarget
DB00182AmphetamineBeta adrenergic receptortarget
DB00182AmphetamineD(2) dopamine receptortarget
DB00182AmphetamineAmine oxidase [flavin-containing] Btarget
DB00182AmphetamineSodium-dependent serotonin transportertarget
DB00182AmphetamineMonoamine oxidasetarget
DB00182Amphetaminevesicular monoamine transporter 2 (VMAT2)target
DB00182AmphetamineSolute carrier family 22 member 3transporter
DB00182AmphetamineSolute carrier family 22 member 5transporter
DB00289AtomoxetineCytochrome P450 2D6enzyme
DB00289AtomoxetineCytochrome P450 2C19enzyme
DB00289AtomoxetineCytochrome P450 3A4enzyme
DB00289AtomoxetineSodium-dependent noradrenaline transportertarget
DB00289AtomoxetineSodium-dependent serotonin transportertarget
DB00289AtomoxetineSodium-dependent dopamine transportertarget
DB00289AtomoxetineNMDA receptortarget
DB00422MethylphenidateCarboxylesteraseenzyme
DB00422MethylphenidateSodium-dependent dopamine transportertarget
DB00422MethylphenidateSodium-dependent noradrenaline transportertarget
DB00422MethylphenidateSodium-dependent serotonin transportertarget
DB00745ModafinilCytochrome P450 3A4enzyme
DB00745ModafinilCytochrome P450 2C19enzyme
DB00745ModafinilCytochrome P450 1A2enzyme
DB00745ModafinilCytochrome P450 2B6enzyme
DB00745ModafinilCytochrome P450 2C9enzyme
DB00745ModafinilCytochrome P450 3A5enzyme
DB00745ModafinilSodium-dependent dopamine transportertarget
DB00745ModafinilAlpha-1B adrenergic receptortarget
DB01255LisdexamfetamineAlpha-1B adrenergic receptortarget
DB01255LisdexamfetamineSodium-dependent dopamine transportertarget
DB01463FencamfamineSodium-dependent dopamine transportertarget
DB01576DextroamphetamineAlpha-1A adrenergic receptortarget
DB01576DextroamphetamineAlpha-1B adrenergic receptortarget
DB01576DextroamphetamineSodium-dependent dopamine transportertarget
DB01576DextroamphetamineSodium-dependent noradrenaline transportertarget
DB01576DextroamphetamineSynaptic vesicular amine transportertarget
DB01576DextroamphetamineTrace amine-associated receptor 1target
DB01577MethamphetamineCytochrome P450 2D6enzyme
DB01577MethamphetamineSodium-dependent dopamine transportertarget
DB01577MethamphetamineSynaptic vesicular amine transportertarget
DB01577MethamphetamineTrace amine-associated receptor 1target
DB01577MethamphetamineSodium-dependent serotonin transportertarget
DB01577MethamphetamineSodium-dependent noradrenaline transportertarget
DB01577MethamphetamineChromaffin granule amine transportertarget
DB01577MethamphetamineAmine oxidase [flavin-containing] Atarget
DB01577MethamphetamineAmine oxidase [flavin-containing] Btarget
DB01577MethamphetamineAlpha-2A adrenergic receptortarget
DB01577MethamphetamineAlpha-2B adrenergic receptortarget
DB01577MethamphetamineAlpha-2C adrenergic receptortarget
DB01577MethamphetamineSolute carrier family 22 member 3transporter
DB01577MethamphetamineSolute carrier family 22 member 5transporter
DB06413ArmodafinilCytochrome P450 2C19enzyme
DB06413ArmodafinilCytochrome P450 3A4enzyme
DB06413ArmodafinilCytochrome P450 1A2enzyme
DB06413ArmodafinilCytochrome P450 2B6enzyme
DB06413ArmodafinilCytochrome P450 3A5enzyme
DB06413ArmodafinilCytochrome P450 2C9enzyme
DB06413ArmodafinilSodium-dependent dopamine transportertarget
DB06701DexmethylphenidateSodium-dependent dopamine transportertarget
DB06701DexmethylphenidateSodium-dependent noradrenaline transportertarget
DB06701DexmethylphenidateSodium-dependent serotonin transportertarget
DB01482FenethyllineCytochrome P450 1A2enzyme