Central Nervous System Stimulation

DrugDrug NameDrug Indication
DB01255LisdexamfetamineFor the treatment of Attention Deficit/Hyperactivity Disorder (ADHD) in pediatric populations aged 6 to 12 years.
DB00201CaffeineFor management of fatigue, orthostatic hypotension, and for the short term treatment of apnea of prematurity in infants.
DB00745ModafinilTo improve wakefulness in patients with excessive daytime sleepiness (EDS) associated with narcolepsy.
DB00182AmphetamineFor treatment of Attention Deficit Disorder with Hyperactivity (ADDH), narcolepsy, and exogenous obesity as a short term (a few weeks) adjunct in a regimen of weight reduction based on caloric restriction for patients refractory to alternative therapy.
DB01577MethamphetamineFor the treatment of Attention Deficit Disorder with Hyperactivity (ADHD) and exogenous obesity.
DB01576DextroamphetamineUsed to treat attention deficit hyperactivity disorder (ADHD).
DB06701DexmethylphenidateDexmethylphenidate is used as a treatment for ADHD, ideally in conjunction with psychological, educational, behavioral or other forms of treatment.
DB00422MethylphenidateFor use as an integral part of a total treatment program which typically includes other remedial measures (psychological, educational, social) for a stabilizing effect in children with a behavioral syndrome characterized by the following group of developmentally inappropriate symptoms: moderate-to-severe distractibility, short attention span, hyperactivity, emotional lability, and impulsivity.
DrugDrug NameTargetType
DB01255LisdexamfetamineAlpha-1B adrenergic receptortarget
DB01255LisdexamfetamineSodium-dependent dopamine transportertarget
DB00201CaffeineAdenosine receptor A1target
DB00201CaffeinecAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
DB00201CaffeineAdenosine receptor A2atarget
DB00201CaffeineCytochrome P450 1A2enzyme
DB00201CaffeineRyanodine receptor 1target
DB00201CaffeineCytochrome P450 3A4enzyme
DB00201CaffeineCytochrome P450 3A5enzyme
DB00201CaffeineCytochrome P450 3A7enzyme
DB00201CaffeineMultidrug resistance protein 1transporter
DB00201CaffeineCytochrome P450 2E1enzyme
DB00201CaffeineCytochrome P450 2C8enzyme
DB00201CaffeineCytochrome P450 2C9enzyme
DB00201CaffeineCytochrome P450 1A1enzyme
DB00201CaffeineCytochrome P450 1B1enzyme
DB00201CaffeineCytochrome P450 2D6enzyme
DB00201CaffeineCyclic nucleotide phosphodiesterasetarget
DB00201CaffeineDNA-dependent protein kinase catalytic subunittarget
DB00201CaffeinePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformtarget
DB00201CaffeinePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformtarget
DB00201CaffeinePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformtarget
DB00201CaffeineInositol 1,4,5-trisphosphate receptortarget
DB00201CaffeineSerine-protein kinase ATMtarget
DB00745ModafinilSodium-dependent dopamine transportertarget
DB00745ModafinilAlpha-1B adrenergic receptortarget
DB00745ModafinilCytochrome P450 3A4enzyme
DB00745ModafinilCytochrome P450 2C19enzyme
DB00745ModafinilCytochrome P450 1A2enzyme
DB00745ModafinilCytochrome P450 2B6enzyme
DB00745ModafinilCytochrome P450 2C9enzyme
DB00745ModafinilCytochrome P450 3A5enzyme
DB00182AmphetamineSodium-dependent dopamine transportertarget
DB00182AmphetamineCocaine- and amphetamine-regulated transcript proteintarget
DB00182AmphetamineTrace amine-associated receptor 1target
DB00182AmphetamineCytochrome P450 2D6enzyme
DB00182AmphetamineSolute carrier family 22 member 3transporter
DB00182AmphetamineSolute carrier family 22 member 5transporter
DB00182AmphetamineSynaptic vesicular amine transportertarget
DB00182AmphetamineCytochrome P450 2A6enzyme
DB00182AmphetamineSodium-dependent noradrenaline transportertarget
DB00182AmphetamineAlpha adrenergic receptortarget
DB00182AmphetamineBeta adrenergic receptortarget
DB00182AmphetamineD(2) dopamine receptortarget
DB00182AmphetamineAmine oxidase [flavin-containing] Btarget
DB00182AmphetamineSodium-dependent serotonin transportertarget
DB00182AmphetamineMonoamine oxidasetarget
DB00182Amphetaminevesicular monoamine transporter 2 (VMAT2)target
DB01577MethamphetamineCytochrome P450 2D6enzyme
DB01577MethamphetamineSolute carrier family 22 member 3transporter
DB01577MethamphetamineSolute carrier family 22 member 5transporter
DB01577MethamphetamineSodium-dependent dopamine transportertarget
DB01577MethamphetamineSynaptic vesicular amine transportertarget
DB01577MethamphetamineTrace amine-associated receptor 1target
DB01577MethamphetamineSodium-dependent serotonin transportertarget
DB01577MethamphetamineSodium-dependent noradrenaline transportertarget
DB01577MethamphetamineChromaffin granule amine transportertarget
DB01577MethamphetamineAmine oxidase [flavin-containing] Atarget
DB01577MethamphetamineAmine oxidase [flavin-containing] Btarget
DB01577MethamphetamineAlpha-2A adrenergic receptortarget
DB01577MethamphetamineAlpha-2B adrenergic receptortarget
DB01577MethamphetamineAlpha-2C adrenergic receptortarget
DB01576DextroamphetamineAlpha-1A adrenergic receptortarget
DB01576DextroamphetamineAlpha-1B adrenergic receptortarget
DB01576DextroamphetamineSodium-dependent dopamine transportertarget
DB01576DextroamphetamineCytochrome P450 2D6enzyme
DB01576DextroamphetamineSodium-dependent noradrenaline transportertarget
DB01576DextroamphetamineSynaptic vesicular amine transportertarget
DB01576DextroamphetamineTrace amine-associated receptor 1target
DB06701DexmethylphenidateSodium-dependent dopamine transportertarget
DB06701DexmethylphenidateSodium-dependent noradrenaline transportertarget
DB06701DexmethylphenidateSodium-dependent serotonin transportertarget
DB06701DexmethylphenidateCytochrome P450 2D6enzyme
DB00422MethylphenidateSodium-dependent dopamine transportertarget
DB00422MethylphenidateSodium-dependent noradrenaline transportertarget
DB00422MethylphenidateSodium-dependent serotonin transportertarget
DB00422MethylphenidateCytochrome P450 2D6enzyme
DB00422MethylphenidateCarboxylesteraseenzyme