Benzenesulfonamides

Name
Benzenesulfonamides
Accession Number
DBCAT005891
Description

A group of compounds that contain sulfonamide group S-linked to a benzene ring. Many benzenesulfonamide derivatives are pharmaceuticals (e.g., BOSENTAN; SULFAPYRIDINE; and SULFADIAZINE; CELECOXIB) as their sulfonamide moiety target various enzymes (e.g., CARBONIC ANHYDRASES; ACETYLCHOLINESTERASE; BUTYRYLCHOLINESTERASE; and CYCLOOXYNENASE 2).

Drugs
DrugDrug Description
SulfanilamideA sulfonamide anti-infective used to treat vulvovaginal candidiasis caused by Candida albicans.
SulfisoxazoleA sulfonamide antibiotic used with other antibiotics to prevent and treat a variety of bacterial infections.
ChlorthalidoneA diuretic used to treat hypertension or edema caused by heart failure, renal failure, hepatic cirrhosis, estrogen therapy, and other conditions.
SulfadiazineA sulfonamide antibiotic used in a variety of infections, such as urinary tract infections, trachoma, and chancroid.
AcetohexamideUsed in the management of diabetes mellitus type 2 (adult-onset).
CelecoxibAn NSAID used to treat osteoarthritis, rheumatoid arthritis, acute pain, menstrual symptoms, and to reduce polyps is familial adenomatous polyposis.
BosentanA dual endothelin receptor antagonist used to treat pulmonary arterial hypertension.
SulfamethizoleA sulfonamide antibiotic used to treat a wide variety of susceptible bacterial infections.
SulfametopyrazineAn antibiotic used in the treatment or prevention of bacterial infections and malaria.
ChlorpropamideA sulfonylurea used in the treatment of non insulin dependent diabetes mellitus.
TamsulosinAn alpha-1A and alpha-1B adrenergic receptor antagonist used to treat benign prostatic hyperplasia, ureteral stones, prostatitis, and female voiding dysfunction.
TolazamideA sulfonylurea used in the treatment of non insulin dependent diabetes mellitus.
SulfapyridineA sulfonamide antibiotic used to treat dermatitis herpetiformis, benign mucous membrane pemphigoid and pyoderma gangrenosum.
SulfamethoxazoleAn oral sulfonamide antibiotic, given in combination with trimethoprim, used to treat a variety of infections of the urinary tract, respiratory system, and gastrointestinal tract.
GliclazideA sulfonylurea used to treat hyperglycemia in patients with type 2 diabetes mellitus.
TolbutamideA sulfonylurea used to treat hyperglycemia in patients with type 2 diabetes mellitus.
SulfadoxineA long acting sulfonamide used for the treatment or prevention of malaria.
SulfamerazineAn antibacterial agent used in the treatment of various bacterial infections, such as bronchitis, prostatitis, and urinary tract infections.
SulfamethazineAn antibacterial agent used in the treatment of various bacterial infections, such as bronchitis, prostatitis, and urinary tract infections.
Silver sulfadiazineA topical sulfonamide antibiotic that acts on the bacterial cell wall and cell membrane; approved for the treatment of burns.
SulfathiazoleSulfathiazole is effective against a wide range of gram positive and gram negative pathogenic microorganisms. Although no longer used in humans, it is used in cattle.
SulfadimethoxineFor use in the treatment of infections.
SulfaphenazoleFor the treatment bacterial infections.
MafenideAn antimicrobial topical agent indicated for use as an adjunctive treatment to control bacterial infection when used under moist dressings over meshed autografts on excised burn wounds.
SulfameterLong acting sulfonamide used in leprosy, urinary, and respiratory tract infections.
SulfamoxoleFor the treatment of bacterial infection.
SulfachlorpyridazineA sulfonamide antimicrobial used for urinary tract infections and in veterinary medicine.
SulfaethoxypyridazineNot Annotated
SulfaquinoxalineSulfaquinoxaline is a veterinary medicine which can be given to cattle and sheep to treat coccidiosis.It is available in Pakistan with Sanna Laboratories in combination with Amprolium and Vitamin K...
SulfaisodimidineSulfaisodimidine also called sulfisomidine is an antibacterial product that has been studied for the treatment of urinary tract infections in the 1950s, however, it is unclear whether this drug has...
CarbutamideNot Annotated
SulfatolamideNot Annotated
SulfaguanidineNot Annotated
SulfamethoxypyridazineA sulphonamide antibiotic indicated in the treatment of gonorrhea, inflammation, urinary tract ulcers, and bronchitis.
Acetyl sulfisoxazoleAcute, recurrent or chronic urinary tract infections (primarily pyelonephritis, pyelitis and cystitis) due to susceptible organisms (usually Escherichia coli, Klebsiella-Enterobacter, staphylococcus, Proteus mirabilis and, less frequently, Proteus vulgaris) in the...
Drugs & Drug Targets
DrugTargetType
SulfanilamideDihydropteroate synthasetarget
SulfisoxazoleDihydropteroate synthasetarget
SulfisoxazoleCytochrome P450 2C9enzyme
ChlorthalidoneSolute carrier family 12 member 1target
ChlorthalidoneSerum albumincarrier
ChlorthalidoneCarbonic anhydrase 1target
SulfadiazineCytochrome P450 2C9enzyme
SulfadiazineDihydropteroate synthetasetarget
SulfadiazineCytochrome P450 2C8enzyme
SulfadiazineCytochrome P450 3A4enzyme
AcetohexamideATP-sensitive inward rectifier potassium channel 1target
AcetohexamideCarbonyl reductase [NADPH] 1enzyme
AcetohexamideSerum albumincarrier
AcetohexamideCytochrome P450 2C9enzyme
CelecoxibProstaglandin G/H synthase 2target
Celecoxib3-phosphoinositide-dependent protein kinase 1target
CelecoxibCytochrome P450 2C9enzyme
CelecoxibCytochrome P450 2D6enzyme
CelecoxibMultidrug resistance-associated protein 4transporter
CelecoxibCytochrome P450 3A4enzyme
CelecoxibCytochrome P450 2C8enzyme
CelecoxibCarbonic anhydrase 2target
CelecoxibCarbonic anhydrase 3target
CelecoxibBile salt export pumptransporter
CelecoxibCadherin-11target
CelecoxibP-glycoprotein 1transporter
CelecoxibATP-binding cassette sub-family G member 2transporter
CelecoxibProstaglandin G/H synthase 2enzyme
CelecoxibSialidase-1target
BosentanEndothelin B receptortarget
BosentanEndothelin-1 receptortarget
BosentanCytochrome P450 3A4enzyme
BosentanCytochrome P450 2C9enzyme
BosentanBile salt export pumptransporter
SulfamethizoleDihydropteroate synthasetarget
SulfamethizoleSerum albumincarrier
SulfamethizoleCytochrome P450 2C9enzyme
SulfametopyrazineDihydropteroate synthetasetarget
ChlorpropamideATP-binding cassette sub-family C member 8target
ChlorpropamideSolute carrier family 15 member 1transporter
ChlorpropamideSolute carrier family 15 member 2transporter
ChlorpropamideSolute carrier family 22 member 6transporter
ChlorpropamideCytochrome P450 2C9enzyme
ChlorpropamideCytochrome P450 2C19enzyme
ChlorpropamideProstaglandin G/H synthase 1enzyme
TamsulosinAlpha-1A adrenergic receptortarget
TamsulosinAlpha-1D adrenergic receptortarget
TamsulosinAlpha-1B adrenergic receptortarget
TamsulosinAlpha-1-acid glycoprotein 1carrier
TamsulosinCytochrome P450 2D6enzyme
TamsulosinCytochrome P450 3A4enzyme
TolazamideSulfonylurea receptor 1, Kir6.2target
TolazamideCytochrome P450 2C9enzyme
SulfapyridineDihydropteroate synthase type-1target
SulfapyridineCytochrome P450 2C9enzyme
SulfamethoxazoleCytochrome P450 2C9enzyme
SulfamethoxazoleSerum albumincarrier
SulfamethoxazoleArylamine N-acetyltransferase 1enzyme
SulfamethoxazoleArylamine N-acetyltransferase 2enzyme
SulfamethoxazoleDihydropteroate synthasetarget
SulfamethoxazoleCytochrome P450 3A4enzyme
SulfamethoxazoleBile salt export pumptransporter
GliclazideATP-binding cassette sub-family C member 8target
GliclazideSerum albumincarrier
GliclazideVascular endothelial growth factor Atarget
GliclazideCytochrome P450 2C9enzyme
GliclazideCytochrome P450 2C19enzyme
TolbutamideATP-sensitive inward rectifier potassium channel 1target
TolbutamideCytochrome P450 2C19enzyme
TolbutamideCytochrome P450 2C9enzyme
TolbutamideCytochrome P450 2C8enzyme
TolbutamideATP-binding cassette sub-family C member 8target
TolbutamideSolute carrier family 15 member 1transporter
TolbutamideSolute carrier organic anion transporter family member 1A2transporter
TolbutamideSolute carrier family 15 member 2transporter
TolbutamideSolute carrier family 22 member 6transporter
TolbutamideSolute carrier organic anion transporter family member 2B1transporter
TolbutamideCytochrome P450 2C18enzyme
TolbutamideSerum albumincarrier
SulfadoxineDihydropteroate synthetasetarget
SulfadoxineBifunctional dihydrofolate reductase-thymidylate synthasetarget
SulfamerazineDihydropteroate synthasetarget
SulfamerazineSerum albumincarrier
SulfamethazineDihydropteroate synthasetarget
SulfamethazineSerum albumincarrier
SulfamethazineArylamine N-acetyltransferaseenzyme
Silver sulfadiazineDNAtarget
SulfathiazoleDihydropteroate synthetasetarget
SulfathiazoleCytochrome P450 19A1enzyme
SulfadimethoxineCytochrome P450 2C9enzyme
SulfadimethoxineSerum albumincarrier
SulfaphenazoleCytochrome P450 2C9enzyme
SulfaphenazoleCytochrome P450 2B6enzyme
SulfaphenazoleCytochrome P450 2C8enzyme
SulfaphenazoleCytochrome P450 2D6enzyme
SulfaphenazoleDihydropteroate synthasetarget
MafenideCarbonic anhydrase 6target
SulfameterDihydropteroate synthasetarget
SulfamoxoleDihydropteroate synthetasetarget
SulfamoxoleCytochrome P450 2C9enzyme
CarbutamideCytochrome P450 2C9enzyme
Acetyl sulfisoxazoleDihydropteroate synthasetarget
Acetyl sulfisoxazoleCytochrome P450 2C9enzyme