Identification

Name
Acetyl sulfisoxazole
Accession Number
DB14033  (DBSALT000856)
Type
Small Molecule
Groups
Approved, Vet approved
Description

Sulfisoxazole acetyl is an ester of sulfisoxazole, a broad-spectrum sulfanilamide and a synthetic analog of para-aminobenzoic acid (PABA) with antibacterial activity. Sulfisoxazole acetyl competes with PABA for the bacterial enzyme, dihydropteroate synthase, preventing the incorporation of PABA into dihydrofolic acid, which is the precursor of folic acid. This process causes an inhibition of bacterial folic acid synthesis and de novo synthesis of purines and pyrimidines, resulting in cell growth arrest and cell death [2].

It is often combined with erythromycin to treat acute otitis media caused by the bacteria, haemophilus influenzae [3].

Structure
Thumb
Synonyms
  • Sulfisoxazole acetyl
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Erythromycin Ethylsuccinate and Sulfisoxazole AcetylAcetyl sulfisoxazole (600 mg/5mL) + Erythromycin ethylsuccinate (200 mg/5mL)Granule, for suspensionOralPhysicians Total Care, Inc.2000-10-11Not applicableUs
Erythromycin Ethylsuccinate and Sulfisoxazole AcetylAcetyl sulfisoxazole (600 mg/5mL) + Erythromycin ethylsuccinate (200 mg/5mL)Granule, for suspensionOralRebel Distributors1988-05-20Not applicableUs
Categories
UNII
WBT5QH3KED
CAS number
80-74-0
Weight
Average: 309.34
Monoisotopic: 309.078327149
Chemical Formula
C13H15N3O4S
InChI Key
JFNWFXVFBDDWCX-UHFFFAOYSA-N
InChI
InChI=1S/C13H15N3O4S/c1-8-9(2)15-20-13(8)16(10(3)17)21(18,19)12-6-4-11(14)5-7-12/h4-7H,14H2,1-3H3
IUPAC Name
N-(4-aminobenzenesulfonyl)-N-(3,4-dimethyl-1,2-oxazol-5-yl)acetamide
SMILES
CC(=O)N(C1=C(C)C(C)=NO1)S(=O)(=O)C1=CC=C(N)C=C1

Pharmacology

Indication

Acute, recurrent or chronic urinary tract infections (primarily pyelonephritis, pyelitis and cystitis) due to susceptible organisms (usually Escherichia coli, Klebsiella-Enterobacter, staphylococcus, Proteus mirabilis and, less frequently, Proteus vulgaris) in the absence of obstructive uropathy or foreign bodies [9]

Meningococcal meningitis where the organism has been demonstrated to be susceptible. Haemophilus influenzae meningitis as adjunctive therapy with parenteral streptomycin [9]

Meningococcal meningitis prophylaxis [9].

Acute otitis media due to Haemophilus influenzae when used concomitantly with adequate doses of penicillin or erythromycin (see appropriate labeling for prescribing information) [9].

Trachoma, inclusion conjunctivitis, nocardiosis, chancroid, toxoplasmosis as adjunctive therapy with pyrimethamine. Malaria due to chloroquine-resistant strains of Plasmodium falciparum, when used as adjunctive therapy [9].

Currently, the increasing frequency of resistant organisms is a limitation of the usefulness of antibacterial agents including the sulfonamides, especially in the treatment of chronic and recurrent urinary tract infections [9].

Pharmacodynamics

Sulfisoxazole is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with action against most gram-positive and many gram-negative organisms. Many strains of an individual species may be resistant to this drugf. Sulfonamides inhibit the multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus [6].

Mechanism of action

Sulfisoxazole is a competitive inhibitor of the enzyme dihydropteroate synthetase. It inhibits bacterial synthesis of dihydrofolic acid by preventing the condensation of the pteridine with para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid [6].

TargetActionsOrganism
ADihydropteroate synthase
inhibitor
Escherichia coli (strain K12)
Absorption

Readily absorbed from the gastrointestinal tract [5].

In a pharmacokinetic study, the adjustments for variable renal clearances between oral and intravenous administration and using the unbound plasma concentrations, the bioavailability for an oral dose of sulfisoxazole was found to be 0.95 +/- 0.04 [7].

Volume of distribution

The sulfonamides are widely distributed throughout all body tissues [5].

It readily crosses the placental barrier and enters into fetal circulation and also crosses the blood-brain barrier. In healthy subjects, cerebrospinal fluid concentrations of sulfisoxazole vary; in patients with meningitis, however, concentrations of free drug in cerebrospinal fluid as high as 94 mcg/mL have been reported [9].

In a pharmacokinetic study, the apparent volume of distribution for total drug was 10.9 +/- 2.0 liters and 136 +/- 36 liters for the unbound drug, indicating that sulfisoxazole is primarily distributed extracellularly [7].

Protein binding

Approximately 85% of a dose of sulfisoxazole is bound to plasma proteins, primarily to albumin; 65% to 72% of the unbound portion is in the nonacetylated form [9].

Metabolism

Sulfisoxazole acetyl is a prodrug of sulfisoxazole. The acetyl group is added to make the drug poorly water-soluble and is hydrolyzed in vivo to the active drug [9], [11].

N1-acetyl sulfisoxazole is metabolized to sulfisoxazole by digestive enzymes in the gastrointestinal tract and is absorbed as sulfisoxazole. This enzymatic splitting is thought to be responsible for slower absorption and lower peak blood concentrations are achieved after administration of an equal oral dose of sulfisoxazole. With sustained administration of acetyl sulfisoxazole, blood concentrations approximate those of sulfisoxazole. Following a single 4 gram dose of acetyl sulfisoxazole to healthy volunteers, maximum plasma concentrations of sulfisoxazole ranged from 122 to 282 mcg/mL (mean, 181 mcg/mL) for the pediatric suspension and occurred between 2 and 6 hours postadministration of sulfisoxazole, in a pharmacokinetic study [9].

Route of elimination

The mean urinary excretion recovery following oral administration of sulfisoxazole is 97% within 48 hours, of which 52% is the parent drug, and the remaining as the N4-acetylated metabolite. It is excreted in human milk [5].

Sulfisoxazole and its acetylated metabolites are excreted primarily by the kidneys through glomerular filtration [9].

Half life

The serum half-life is 10 -12 hours [5].

Clearance

The clearance of sulfisoxazole is 18.7 +/- 3.9 ml/min for total drug and 232 +/- 64 ml/min for the unbound drug [7].

Toxicity

LD50=6800 mg/kg (Orally in mice) [10].

Sulfonamide-induced hypersensitivity reactions, although uncommon, can be severe. They can include rare life-threatening cutaneous reactions such as erythema multiform (Stevens-Johnson syndrome) and toxic epidermal necrolysis. Crystalluria may result in dysuria, renal colic, haematuria and acute renal obstruction [8].

Other infrequent reactions include granulocytopenia, agranulocytosis, aplastic anemia, thrombocytopenic purpura and toxic hepatitis. Rarely, hemolysis may occur in individuals deficient in glucose-6-phosphate dehydrogenase [8].

The severe or irreversible adverse effects of sulfisoxazole, which give rise to more complications which may include: nephrotoxicity, blood dyscrasias, interstitial nephritis, hematuria, crystalluria, oliguria, anuria, lumbar pain, and tubular necrosis [8].

The symptomatic adverse reactions produced by sulfisoxazole are more or less tolerable and if severe, may be treated symptomatically, these include anorexia, diarrhea, rashes, pruritus, nausea and vomiting, hypersensitivity reactions, Photosensitivity reactions [5].

Overdosage: Continuously forced diuresis may be beneficial and an alkaline urine should be initiated [5].

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
AbemaciclibThe metabolism of Abemaciclib can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
AbirateroneThe metabolism of Abiraterone can be decreased when combined with Acetyl sulfisoxazole.Approved
AceclofenacThe metabolism of Aceclofenac can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
AcenocoumarolThe metabolism of Acenocoumarol can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
AcetaminophenThe metabolism of Acetaminophen can be decreased when combined with Acetyl sulfisoxazole.Approved
Acetylsalicylic acidThe metabolism of Acetylsalicylic acid can be decreased when combined with Acetyl sulfisoxazole.Approved, Vet Approved
AdinazolamThe metabolism of Adinazolam can be decreased when combined with Acetyl sulfisoxazole.Approved
AlbendazoleThe metabolism of Albendazole can be decreased when combined with Acetyl sulfisoxazole.Approved, Vet Approved
AlclometasoneThe metabolism of Alclometasone can be decreased when combined with Acetyl sulfisoxazole.Approved
AlfentanilThe metabolism of Alfentanil can be decreased when combined with Acetyl sulfisoxazole.Approved, Illicit
AlfuzosinThe metabolism of Alfuzosin can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
AliskirenThe metabolism of Aliskiren can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
AllylestrenolThe metabolism of Allylestrenol can be decreased when combined with Acetyl sulfisoxazole.Approved
AlmotriptanThe metabolism of Almotriptan can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
AlogliptinThe metabolism of Alogliptin can be decreased when combined with Acetyl sulfisoxazole.Approved
AlosetronThe metabolism of Alosetron can be decreased when combined with Acetyl sulfisoxazole.Approved, Withdrawn
alpha-Tocopherol acetateThe metabolism of alpha-Tocopherol acetate can be decreased when combined with Acetyl sulfisoxazole.Approved
AlprazolamThe metabolism of Alprazolam can be decreased when combined with Acetyl sulfisoxazole.Approved, Illicit, Investigational
AmbrisentanThe metabolism of Ambrisentan can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
AmbroxolThe metabolism of Ambroxol can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Acetyl sulfisoxazole.Approved, Withdrawn
AminophyllineThe metabolism of Aminophylline can be decreased when combined with Acetyl sulfisoxazole.Approved
AmiodaroneThe metabolism of Acetyl sulfisoxazole can be decreased when combined with Amiodarone.Approved, Investigational
AmitriptylineThe metabolism of Amitriptyline can be decreased when combined with Acetyl sulfisoxazole.Approved
AmlodipineThe metabolism of Amlodipine can be decreased when combined with Acetyl sulfisoxazole.Approved
AmprenavirThe metabolism of Amprenavir can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
ApalutamideThe serum concentration of Acetyl sulfisoxazole can be decreased when it is combined with Apalutamide.Approved, Investigational
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Acetyl sulfisoxazole.Approved
ApremilastThe metabolism of Apremilast can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
AprepitantThe metabolism of Acetyl sulfisoxazole can be increased when combined with Aprepitant.Approved, Investigational
Arachidonic AcidThe metabolism of Arachidonic Acid can be decreased when combined with Acetyl sulfisoxazole.Experimental
ArformoterolThe metabolism of Arformoterol can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
ArgatrobanThe metabolism of Argatroban can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Acetyl sulfisoxazole.Approved, Investigational
ArtemetherThe metabolism of Artemether can be decreased when combined with Acetyl sulfisoxazole.Approved
AsenapineThe metabolism of Asenapine can be decreased when combined with Acetyl sulfisoxazole.Approved
AstemizoleThe metabolism of Astemizole can be decreased when combined with Acetyl sulfisoxazole.Approved, Withdrawn
AsunaprevirThe serum concentration of Asunaprevir can be increased when it is combined with Acetyl sulfisoxazole.Approved, Investigational, Withdrawn
AtazanavirThe metabolism of Atazanavir can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
AtorvastatinThe risk or severity of adverse effects can be increased when Acetyl sulfisoxazole is combined with Atorvastatin.Approved
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Acetyl sulfisoxazole.Approved
AvatrombopagThe metabolism of Avatrombopag can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
AxitinibThe metabolism of Axitinib can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
AzelastineThe metabolism of Azelastine can be decreased when combined with Acetyl sulfisoxazole.Approved
AzithromycinThe metabolism of Azithromycin can be decreased when combined with Acetyl sulfisoxazole.Approved
BanoxantroneThe metabolism of Banoxantrone can be decreased when combined with Acetyl sulfisoxazole.Investigational
BaricitinibThe metabolism of Baricitinib can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
BedaquilineThe metabolism of Bedaquiline can be decreased when combined with Acetyl sulfisoxazole.Approved
BenidipineThe metabolism of Benidipine can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
BenzphetamineThe metabolism of Benzphetamine can be decreased when combined with Acetyl sulfisoxazole.Approved, Illicit
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Acetyl sulfisoxazole.Approved
BexaroteneThe metabolism of Bexarotene can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
BezafibrateThe metabolism of Bezafibrate can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
BicalutamideThe metabolism of Bicalutamide can be decreased when combined with Acetyl sulfisoxazole.Approved
BictegravirThe metabolism of Bictegravir can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
BioallethrinThe metabolism of Bioallethrin can be decreased when combined with Acetyl sulfisoxazole.Approved, Experimental
BisoprololThe metabolism of Bisoprolol can be decreased when combined with Acetyl sulfisoxazole.Approved
BlonanserinThe metabolism of Blonanserin can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
BoceprevirThe metabolism of Boceprevir can be decreased when combined with Acetyl sulfisoxazole.Approved, Withdrawn
BortezomibThe metabolism of Bortezomib can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
BosentanThe serum concentration of Bosentan can be increased when it is combined with Acetyl sulfisoxazole.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Acetyl sulfisoxazole.Approved
Brentuximab vedotinThe metabolism of Brentuximab vedotin can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Acetyl sulfisoxazole.Approved, Investigational
BrigatinibThe metabolism of Brigatinib can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
BrinzolamideThe metabolism of Brinzolamide can be decreased when combined with Acetyl sulfisoxazole.Approved
BrivaracetamThe metabolism of Brivaracetam can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
BromazepamThe metabolism of Bromazepam can be decreased when combined with Acetyl sulfisoxazole.Approved, Illicit, Investigational
BromocriptineThe risk or severity of adverse effects can be increased when Bromocriptine is combined with Acetyl sulfisoxazole.Approved, Investigational
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Acetyl sulfisoxazole.Approved
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Acetyl sulfisoxazole.Approved
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
BuprenorphineThe metabolism of Buprenorphine can be decreased when combined with Acetyl sulfisoxazole.Approved, Illicit, Investigational, Vet Approved
BupropionThe metabolism of Bupropion can be decreased when combined with Acetyl sulfisoxazole.Approved
BuspironeThe metabolism of Buspirone can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
BusulfanThe metabolism of Busulfan can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
CabazitaxelThe metabolism of Cabazitaxel can be decreased when combined with Acetyl sulfisoxazole.Approved
CabergolineThe risk or severity of adverse effects can be increased when Cabergoline is combined with Acetyl sulfisoxazole.Approved
CabozantinibThe metabolism of Cabozantinib can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
CaffeineThe metabolism of Caffeine can be decreased when combined with Acetyl sulfisoxazole.Approved
CalcitriolThe metabolism of Calcitriol can be decreased when combined with Acetyl sulfisoxazole.Approved, Nutraceutical
CanagliflozinThe metabolism of Canagliflozin can be decreased when combined with Acetyl sulfisoxazole.Approved
CandesartanThe metabolism of Candesartan can be decreased when combined with Acetyl sulfisoxazole.Experimental
Candesartan cilexetilThe metabolism of Candesartan cilexetil can be decreased when combined with Acetyl sulfisoxazole.Approved
CannabidiolThe metabolism of Cannabidiol can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
CapecitabineThe metabolism of Acetyl sulfisoxazole can be decreased when combined with Capecitabine.Approved, Investigational
CarbamazepineThe metabolism of Acetyl sulfisoxazole can be increased when combined with Carbamazepine.Approved, Investigational
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Acetyl sulfisoxazole.Approved
CariprazineThe metabolism of Cariprazine can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
CarvedilolThe serum concentration of Carvedilol can be increased when it is combined with Acetyl sulfisoxazole.Approved, Investigational
CelecoxibThe metabolism of Celecoxib can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
CeliprololThe metabolism of Celiprolol can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
CephalexinThe metabolism of Cephalexin can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational, Vet Approved
CeritinibThe serum concentration of Acetyl sulfisoxazole can be increased when it is combined with Ceritinib.Approved
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Acetyl sulfisoxazole.Approved, Withdrawn
CevimelineThe metabolism of Cevimeline can be decreased when combined with Acetyl sulfisoxazole.Approved
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be decreased when combined with Acetyl sulfisoxazole.Approved
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Acetyl sulfisoxazole.Approved, Illicit, Investigational
ChloroquineThe metabolism of Chloroquine can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational, Vet Approved
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Acetyl sulfisoxazole.Approved
ChlorpromazineThe metabolism of Chlorpromazine can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational, Vet Approved
ChlorpropamideThe metabolism of Chlorpropamide can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Acetyl sulfisoxazole.Approved
CholecalciferolThe metabolism of Cholecalciferol can be decreased when combined with Acetyl sulfisoxazole.Approved, Nutraceutical
CiclesonideThe metabolism of Ciclesonide can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Acetyl sulfisoxazole.Approved, Investigational
CinacalcetThe metabolism of Cinacalcet can be decreased when combined with Acetyl sulfisoxazole.Approved
CinnarizineThe metabolism of Cinnarizine can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
CisaprideThe metabolism of Cisapride can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational, Withdrawn
CitalopramThe metabolism of Citalopram can be decreased when combined with Acetyl sulfisoxazole.Approved
ClarithromycinThe metabolism of Clarithromycin can be decreased when combined with Acetyl sulfisoxazole.Approved
ClindamycinThe metabolism of Clindamycin can be decreased when combined with Acetyl sulfisoxazole.Approved, Vet Approved
ClobazamThe metabolism of Clobazam can be decreased when combined with Acetyl sulfisoxazole.Approved, Illicit
ClofazimineThe metabolism of Clofazimine can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
ClofibrateThe metabolism of Clofibrate can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
clomethiazoleThe metabolism of clomethiazole can be decreased when combined with Acetyl sulfisoxazole.Investigational
ClomipramineThe metabolism of Clomipramine can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational, Vet Approved
ClonazepamThe metabolism of Clonazepam can be decreased when combined with Acetyl sulfisoxazole.Approved, Illicit
ClonidineThe metabolism of Clonidine can be decreased when combined with Acetyl sulfisoxazole.Approved
ClopidogrelThe metabolism of Clopidogrel can be decreased when combined with Acetyl sulfisoxazole.Approved
ClorazepateThe metabolism of Clorazepate can be decreased when combined with Acetyl sulfisoxazole.Approved, Illicit
ClotiazepamThe metabolism of Clotiazepam can be decreased when combined with Acetyl sulfisoxazole.Approved, Illicit
ClotrimazoleThe metabolism of Acetyl sulfisoxazole can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineThe metabolism of Clozapine can be decreased when combined with Acetyl sulfisoxazole.Approved
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Acetyl sulfisoxazole.Approved, Investigational
CocaineThe metabolism of Cocaine can be decreased when combined with Acetyl sulfisoxazole.Approved, Illicit
CodeineThe metabolism of Codeine can be decreased when combined with Acetyl sulfisoxazole.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Acetyl sulfisoxazole.Approved
ConivaptanThe metabolism of Conivaptan can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
Conjugated estrogensThe metabolism of Conjugated estrogens can be decreased when combined with Acetyl sulfisoxazole.Approved
CopanlisibThe metabolism of Copanlisib can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
Cortisone acetateThe metabolism of Cortisone acetate can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
CrisaboroleThe metabolism of Acetyl sulfisoxazole can be decreased when combined with Crisaborole.Approved, Investigational
CrizotinibThe metabolism of Crizotinib can be decreased when combined with Acetyl sulfisoxazole.Approved
CurcuminThe metabolism of Acetyl sulfisoxazole can be decreased when combined with Curcumin.Approved, Investigational
CyclobenzaprineThe metabolism of Cyclobenzaprine can be decreased when combined with Acetyl sulfisoxazole.Approved
CyclophosphamideThe metabolism of Cyclophosphamide can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
CyclosporineThe metabolism of Cyclosporine can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational, Vet Approved
CytarabineThe metabolism of Cytarabine can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
DabrafenibThe serum concentration of Acetyl sulfisoxazole can be decreased when it is combined with Dabrafenib.Approved, Investigational
DaclatasvirThe metabolism of Daclatasvir can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
DantroleneThe metabolism of Dantrolene can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
DapagliflozinThe metabolism of Dapagliflozin can be decreased when combined with Acetyl sulfisoxazole.Approved
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Acetyl sulfisoxazole.Investigational
DapsoneThe metabolism of Dapsone can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
DarunavirThe metabolism of Darunavir can be decreased when combined with Acetyl sulfisoxazole.Approved
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Acetyl sulfisoxazole.Approved
DasatinibThe metabolism of Dasatinib can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
DaunorubicinThe metabolism of Daunorubicin can be decreased when combined with Acetyl sulfisoxazole.Approved
DeflazacortThe metabolism of Deflazacort can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
DelamanidThe metabolism of Delamanid can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
DelavirdineThe metabolism of Acetyl sulfisoxazole can be decreased when combined with Delavirdine.Approved
DesvenlafaxineThe metabolism of Desvenlafaxine can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
DeutetrabenazineThe metabolism of Deutetrabenazine can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
DexamethasoneThe metabolism of Dexamethasone can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational, Vet Approved
Dexchlorpheniramine maleateThe metabolism of Dexchlorpheniramine maleate can be decreased when combined with Acetyl sulfisoxazole.Approved
DexketoprofenThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Acetyl sulfisoxazole.Approved, Investigational
DexlansoprazoleThe metabolism of Dexlansoprazole can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Acetyl sulfisoxazole.Approved
DextropropoxypheneThe metabolism of Dextropropoxyphene can be decreased when combined with Acetyl sulfisoxazole.Approved, Illicit, Investigational, Withdrawn
DiazepamThe metabolism of Diazepam can be decreased when combined with Acetyl sulfisoxazole.Approved, Illicit, Investigational, Vet Approved
DiclofenacThe serum concentration of Diclofenac can be increased when it is combined with Acetyl sulfisoxazole.Approved, Vet Approved
DicoumarolThe metabolism of Dicoumarol can be decreased when combined with Acetyl sulfisoxazole.Approved
DienogestThe metabolism of Dienogest can be decreased when combined with Acetyl sulfisoxazole.Approved
DigitoxinThe metabolism of Digitoxin can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
DigoxinThe metabolism of Digoxin can be decreased when combined with Acetyl sulfisoxazole.Approved
Dihydro-alpha-ergocryptineThe metabolism of Dihydro-alpha-ergocryptine can be decreased when combined with Acetyl sulfisoxazole.Approved
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Acetyl sulfisoxazole.Approved, Illicit
DihydroergocornineThe risk or severity of adverse effects can be increased when Dihydroergocornine is combined with Acetyl sulfisoxazole.Approved
DihydroergocristineThe risk or severity of adverse effects can be increased when Dihydroergocristine is combined with Acetyl sulfisoxazole.Approved, Experimental
DihydroergocryptineThe risk or severity of adverse effects can be increased when Dihydroergocryptine is combined with Acetyl sulfisoxazole.Experimental
DihydroergotamineThe risk or severity of adverse effects can be increased when Dihydroergotamine is combined with Acetyl sulfisoxazole.Approved, Investigational
DiltiazemThe metabolism of Diltiazem can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
DiphenhydramineThe metabolism of Diphenhydramine can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
DisopyramideThe metabolism of Disopyramide can be decreased when combined with Acetyl sulfisoxazole.Approved
DisulfiramThe metabolism of Disulfiram can be decreased when combined with Acetyl sulfisoxazole.Approved
DocetaxelThe metabolism of Docetaxel can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
DoconexentThe metabolism of Doconexent can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Acetyl sulfisoxazole.Approved, Investigational
DolasetronThe metabolism of Dolasetron can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Acetyl sulfisoxazole.Approved, Investigational, Vet Approved
DonepezilThe metabolism of Donepezil can be decreased when combined with Acetyl sulfisoxazole.Approved
DopamineThe metabolism of Dopamine can be decreased when combined with Acetyl sulfisoxazole.Approved
DorzolamideThe metabolism of Dorzolamide can be decreased when combined with Acetyl sulfisoxazole.Approved
DosulepinThe metabolism of Acetyl sulfisoxazole can be decreased when combined with Dosulepin.Approved
DoxepinThe metabolism of Doxepin can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Acetyl sulfisoxazole.Approved, Investigational
DoxorubicinThe metabolism of Doxorubicin can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Acetyl sulfisoxazole.Approved, Illicit
DronedaroneThe metabolism of Dronedarone can be decreased when combined with Acetyl sulfisoxazole.Approved
DutasterideThe metabolism of Dutasteride can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
EfavirenzThe metabolism of Efavirenz can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
ElbasvirThe metabolism of Elbasvir can be decreased when combined with Acetyl sulfisoxazole.Approved
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Acetyl sulfisoxazole.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Acetyl sulfisoxazole.Approved
ElvitegravirThe metabolism of Elvitegravir can be decreased when combined with Acetyl sulfisoxazole.Approved
EnalaprilThe metabolism of Enalapril can be decreased when combined with Acetyl sulfisoxazole.Approved, Vet Approved
EnasidenibThe metabolism of Enasidenib can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
EnzalutamideThe metabolism of Enzalutamide can be decreased when combined with Acetyl sulfisoxazole.Approved
EpinastineThe metabolism of Epinastine can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Acetyl sulfisoxazole.Approved
EpoprostenolThe metabolism of Epoprostenol can be decreased when combined with Acetyl sulfisoxazole.Approved
ErgocalciferolThe metabolism of Ergocalciferol can be decreased when combined with Acetyl sulfisoxazole.Approved, Nutraceutical
Ergoloid mesylateThe metabolism of Ergoloid mesylate can be decreased when combined with Acetyl sulfisoxazole.Approved
ErgonovineThe risk or severity of adverse effects can be increased when Ergonovine is combined with Acetyl sulfisoxazole.Approved
ErgotamineThe risk or severity of adverse effects can be increased when Ergotamine is combined with Acetyl sulfisoxazole.Approved
ErlotinibThe metabolism of Erlotinib can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
ErythromycinThe metabolism of Erythromycin can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational, Vet Approved
EscitalopramThe metabolism of Escitalopram can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
EsomeprazoleThe metabolism of Esomeprazole can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
EstazolamThe metabolism of Estazolam can be decreased when combined with Acetyl sulfisoxazole.Approved, Illicit
EstradiolThe metabolism of Estradiol can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational, Vet Approved
Estradiol acetateThe metabolism of Estradiol acetate can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational, Vet Approved
Estradiol benzoateThe metabolism of Estradiol benzoate can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational, Vet Approved
Estradiol cypionateThe metabolism of Estradiol cypionate can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational, Vet Approved
Estradiol dienanthateThe metabolism of Estradiol dienanthate can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational, Vet Approved
Estradiol valerateThe metabolism of Estradiol valerate can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational, Vet Approved
EstramustineThe metabolism of Estramustine can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
Estrogens, esterifiedThe metabolism of Estrogens, esterified can be decreased when combined with Acetyl sulfisoxazole.Approved
EstroneThe metabolism of Estrone can be decreased when combined with Acetyl sulfisoxazole.Approved
Estrone sulfateThe metabolism of Estrone sulfate can be decreased when combined with Acetyl sulfisoxazole.Approved
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
EthanolThe metabolism of Ethanol can be decreased when combined with Acetyl sulfisoxazole.Approved
Ethinyl EstradiolThe metabolism of Ethinyl Estradiol can be decreased when combined with Acetyl sulfisoxazole.Approved
EthosuximideThe metabolism of Ethosuximide can be decreased when combined with Acetyl sulfisoxazole.Approved
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Acetyl sulfisoxazole.Approved, Illicit
EtizolamThe metabolism of Etizolam can be decreased when combined with Acetyl sulfisoxazole.Approved
EtodolacThe metabolism of Etodolac can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational, Vet Approved
EtonogestrelThe metabolism of Etonogestrel can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
EtoposideThe metabolism of Etoposide can be decreased when combined with Acetyl sulfisoxazole.Approved
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
EtravirineThe metabolism of Etravirine can be decreased when combined with Acetyl sulfisoxazole.Approved
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Acetyl sulfisoxazole.Approved
ExemestaneThe metabolism of Exemestane can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
FamciclovirThe metabolism of Famciclovir can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
FelbamateThe metabolism of Felbamate can be decreased when combined with Acetyl sulfisoxazole.Approved
FelodipineThe metabolism of Felodipine can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
FenofibrateThe metabolism of Fenofibrate can be decreased when combined with Acetyl sulfisoxazole.Approved
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Acetyl sulfisoxazole.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe metabolism of Fesoterodine can be decreased when combined with Acetyl sulfisoxazole.Approved
FinasterideThe metabolism of Finasteride can be decreased when combined with Acetyl sulfisoxazole.Approved
FingolimodThe metabolism of Fingolimod can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
FlibanserinThe risk or severity of adverse effects can be increased when Acetyl sulfisoxazole is combined with Flibanserin.Approved, Investigational
FloxuridineThe metabolism of Acetyl sulfisoxazole can be decreased when combined with Floxuridine.Approved
FluconazoleThe metabolism of Acetyl sulfisoxazole can be decreased when combined with Fluconazole.Approved, Investigational
FlunarizineThe metabolism of Flunarizine can be decreased when combined with Acetyl sulfisoxazole.Approved
FlunisolideThe metabolism of Flunisolide can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Acetyl sulfisoxazole.Approved, Illicit
FluorometholoneThe metabolism of Fluorometholone can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
FluorouracilThe metabolism of Acetyl sulfisoxazole can be decreased when combined with Fluorouracil.Approved
FluoxetineThe metabolism of Fluoxetine can be decreased when combined with Acetyl sulfisoxazole.Approved, Vet Approved
FlurazepamThe metabolism of Flurazepam can be decreased when combined with Acetyl sulfisoxazole.Approved, Illicit, Investigational
FlurbiprofenThe metabolism of Flurbiprofen can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
FlutamideThe metabolism of Flutamide can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
Fluticasone furoateThe metabolism of Fluticasone furoate can be decreased when combined with Acetyl sulfisoxazole.Approved
Fluticasone propionateThe metabolism of Fluticasone propionate can be decreased when combined with Acetyl sulfisoxazole.Approved
FluvastatinThe serum concentration of Fluvastatin can be increased when it is combined with Acetyl sulfisoxazole.Approved
FluvoxamineThe metabolism of Acetyl sulfisoxazole can be decreased when combined with Fluvoxamine.Approved, Investigational
FormoterolThe metabolism of Formoterol can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
FosamprenavirThe metabolism of Fosamprenavir can be decreased when combined with Acetyl sulfisoxazole.Approved
FosnetupitantThe metabolism of Fosnetupitant can be decreased when combined with Acetyl sulfisoxazole.Approved
FosphenytoinThe metabolism of Acetyl sulfisoxazole can be increased when combined with Fosphenytoin.Approved, Investigational
FostamatinibThe metabolism of Fostamatinib can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
FulvestrantThe metabolism of Fulvestrant can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
GalantamineThe metabolism of Galantamine can be decreased when combined with Acetyl sulfisoxazole.Approved
GavestinelThe metabolism of Gavestinel can be decreased when combined with Acetyl sulfisoxazole.Investigational
GefitinibThe metabolism of Gefitinib can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
GemfibrozilThe metabolism of Acetyl sulfisoxazole can be decreased when combined with Gemfibrozil.Approved
GliclazideThe metabolism of Gliclazide can be decreased when combined with Acetyl sulfisoxazole.Approved
GlimepirideThe metabolism of Glimepiride can be decreased when combined with Acetyl sulfisoxazole.Approved
GlipizideThe metabolism of Glipizide can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
GlyburideThe metabolism of Glyburide can be decreased when combined with Acetyl sulfisoxazole.Approved
GranisetronThe metabolism of Granisetron can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
GrazoprevirThe metabolism of Grazoprevir can be decreased when combined with Acetyl sulfisoxazole.Approved
GrepafloxacinThe metabolism of Grepafloxacin can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational, Withdrawn
GuanfacineThe metabolism of Guanfacine can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Acetyl sulfisoxazole.Approved
HaloperidolThe metabolism of Haloperidol can be decreased when combined with Acetyl sulfisoxazole.Approved
HalothaneThe metabolism of Halothane can be decreased when combined with Acetyl sulfisoxazole.Approved, Vet Approved
HexobarbitalThe metabolism of Hexobarbital can be decreased when combined with Acetyl sulfisoxazole.Approved
HistamineThe metabolism of Histamine can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Acetyl sulfisoxazole.Approved, Illicit
HydrocortisoneThe metabolism of Hydrocortisone can be decreased when combined with Acetyl sulfisoxazole.Approved, Vet Approved
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Acetyl sulfisoxazole.Approved, Illicit
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Acetyl sulfisoxazole.Approved
IbuprofenThe metabolism of Ibuprofen can be decreased when combined with Acetyl sulfisoxazole.Approved
IcotinibThe metabolism of Icotinib can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
IdarubicinThe metabolism of Idarubicin can be decreased when combined with Acetyl sulfisoxazole.Approved
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Acetyl sulfisoxazole resulting in a loss in efficacy.Approved
IloperidoneThe metabolism of Iloperidone can be decreased when combined with Acetyl sulfisoxazole.Approved
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Acetyl sulfisoxazole.Approved
ImidafenacinThe metabolism of Imidafenacin can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
ImipramineThe metabolism of Imipramine can be decreased when combined with Acetyl sulfisoxazole.Approved
ImiquimodThe metabolism of Imiquimod can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
IndacaterolThe metabolism of Indacaterol can be decreased when combined with Acetyl sulfisoxazole.Approved
IndapamideThe metabolism of Indapamide can be decreased when combined with Acetyl sulfisoxazole.Approved
IndinavirThe metabolism of Indinavir can be decreased when combined with Acetyl sulfisoxazole.Approved
IndisulamThe metabolism of Indisulam can be decreased when combined with Acetyl sulfisoxazole.Investigational
IndomethacinThe metabolism of Indomethacin can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
IpecacThe metabolism of Ipecac can be decreased when combined with Acetyl sulfisoxazole.Approved, Withdrawn
IpratropiumThe metabolism of Ipratropium bromide can be decreased when combined with Acetyl sulfisoxazole.Approved
IrbesartanThe metabolism of Irbesartan can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
IrinotecanThe metabolism of Irinotecan can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
IsavuconazoleThe metabolism of Isavuconazole can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
IsavuconazoniumThe metabolism of Isavuconazonium can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be decreased when combined with Acetyl sulfisoxazole.Approved
IsradipineThe metabolism of Isradipine can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
ItraconazoleThe metabolism of Itraconazole can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Acetyl sulfisoxazole.Approved
IvacaftorThe serum concentration of Ivacaftor can be increased when it is combined with Acetyl sulfisoxazole.Approved
IvermectinThe metabolism of Ivermectin can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational, Vet Approved
IxabepiloneThe metabolism of Ixabepilone can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
IxazomibThe metabolism of Ixazomib can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
KetamineThe metabolism of Ketamine can be decreased when combined with Acetyl sulfisoxazole.Approved, Vet Approved
KetazolamThe metabolism of Ketazolam can be decreased when combined with Acetyl sulfisoxazole.Approved
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
KetoconazoleThe metabolism of Ketoconazole can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
KetoprofenThe metabolism of Ketoprofen can be decreased when combined with Acetyl sulfisoxazole.Approved, Vet Approved
LacidipineThe metabolism of Lacidipine can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
LacosamideThe serum concentration of Lacosamide can be increased when it is combined with Acetyl sulfisoxazole.Approved
LansoprazoleThe metabolism of Lansoprazole can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
LapatinibThe metabolism of Lapatinib can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
LaquinimodThe metabolism of Laquinimod can be decreased when combined with Acetyl sulfisoxazole.Investigational
LeflunomideThe metabolism of Leflunomide can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
LenvatinibThe metabolism of Lenvatinib can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
LercanidipineThe metabolism of Lercanidipine can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
LesinuradThe metabolism of Lesinurad can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
LetrozoleThe metabolism of Letrozole can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
LevobupivacaineThe metabolism of Levobupivacaine can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
LevocetirizineThe metabolism of Levocetirizine can be decreased when combined with Acetyl sulfisoxazole.Approved
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
LevomilnacipranThe metabolism of Levomilnacipran can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
LevonorgestrelThe metabolism of Levonorgestrel can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
LevothyroxineThe metabolism of Levothyroxine can be decreased when combined with Acetyl sulfisoxazole.Approved
LicofeloneThe metabolism of Licofelone can be decreased when combined with Acetyl sulfisoxazole.Investigational
LidocaineThe metabolism of Lidocaine can be decreased when combined with Acetyl sulfisoxazole.Approved, Vet Approved
LisurideThe risk or severity of adverse effects can be increased when Lisuride is combined with Acetyl sulfisoxazole.Approved, Investigational
LobeglitazoneThe metabolism of Acetyl sulfisoxazole can be decreased when combined with Lobeglitazone.Approved, Investigational
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Acetyl sulfisoxazole.Approved, Investigational
LoperamideThe metabolism of Loperamide can be decreased when combined with Acetyl sulfisoxazole.Approved
LopinavirThe metabolism of Lopinavir can be decreased when combined with Acetyl sulfisoxazole.Approved
LoratadineThe metabolism of Loratadine can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Acetyl sulfisoxazole.Approved
LornoxicamThe metabolism of Lornoxicam can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
LorpiprazoleThe metabolism of Lorpiprazole can be decreased when combined with Acetyl sulfisoxazole.Approved
LosartanThe metabolism of Losartan can be decreased when combined with Acetyl sulfisoxazole.Approved
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Acetyl sulfisoxazole.Approved, Investigational
LumacaftorThe serum concentration of Acetyl sulfisoxazole can be decreased when it is combined with Lumacaftor.Approved
LumefantrineThe metabolism of Lumefantrine can be decreased when combined with Acetyl sulfisoxazole.Approved
LumiracoxibThe metabolism of Lumiracoxib can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Acetyl sulfisoxazole.Approved, Investigational
Lysergic Acid DiethylamideThe risk or severity of adverse effects can be increased when Lysergic Acid Diethylamide is combined with Acetyl sulfisoxazole.Illicit, Investigational, Withdrawn
MacimorelinThe metabolism of Macimorelin can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
MacitentanThe metabolism of Macitentan can be decreased when combined with Acetyl sulfisoxazole.Approved
ManidipineThe metabolism of Acetyl sulfisoxazole can be decreased when combined with Manidipine.Approved, Investigational
MaravirocThe metabolism of Maraviroc can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
MebendazoleThe metabolism of Mebendazole can be decreased when combined with Acetyl sulfisoxazole.Approved, Vet Approved
MecamylamineThe risk or severity of adverse effects can be increased when Acetyl sulfisoxazole is combined with Mecamylamine.Approved, Investigational
Medical CannabisThe metabolism of Medical Cannabis can be decreased when combined with Acetyl sulfisoxazole.Experimental, Investigational
Medroxyprogesterone acetateThe metabolism of Medroxyprogesterone acetate can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
Mefenamic acidThe metabolism of Mefenamic acid can be decreased when combined with Acetyl sulfisoxazole.Approved
MefloquineThe metabolism of Mefloquine can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
MelatoninThe metabolism of Melatonin can be decreased when combined with Acetyl sulfisoxazole.Approved, Nutraceutical, Vet Approved
MeloxicamThe metabolism of Meloxicam can be decreased when combined with Acetyl sulfisoxazole.Approved, Vet Approved
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Acetyl sulfisoxazole.Investigational, Withdrawn
MestranolThe metabolism of Mestranol can be decreased when combined with Acetyl sulfisoxazole.Approved
MetergolineThe risk or severity of adverse effects can be increased when Metergoline is combined with Acetyl sulfisoxazole.Experimental
MethadoneThe metabolism of Methadone can be decreased when combined with Acetyl sulfisoxazole.Approved
MethaqualoneThe metabolism of Methaqualone can be decreased when combined with Acetyl sulfisoxazole.Illicit, Withdrawn
MethoxsalenThe metabolism of Methoxsalen can be decreased when combined with Acetyl sulfisoxazole.Approved
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational, Vet Approved
MethylergometrineThe risk or severity of adverse effects can be increased when Methylergometrine is combined with Acetyl sulfisoxazole.Approved
MethylprednisoloneThe metabolism of Methylprednisolone can be decreased when combined with Acetyl sulfisoxazole.Approved, Vet Approved
MethyltestosteroneThe metabolism of Methyltestosterone can be decreased when combined with Acetyl sulfisoxazole.Approved
MethysergideThe risk or severity of adverse effects can be increased when Methysergide is combined with Acetyl sulfisoxazole.Approved
MetronidazoleThe metabolism of Metronidazole can be decreased when combined with Acetyl sulfisoxazole.Approved
MevastatinThe serum concentration of Mevastatin can be increased when it is combined with Acetyl sulfisoxazole.Experimental
MexiletineThe metabolism of Mexiletine can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
MianserinThe metabolism of Mianserin can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
MibefradilThe metabolism of Mibefradil can be decreased when combined with Acetyl sulfisoxazole.Investigational, Withdrawn
MiconazoleThe metabolism of Miconazole can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational, Vet Approved
MidazolamThe metabolism of Midazolam can be decreased when combined with Acetyl sulfisoxazole.Approved, Illicit
MidecamycinThe metabolism of Midecamycin can be decreased when combined with Acetyl sulfisoxazole.Approved
MidostaurinThe metabolism of Acetyl sulfisoxazole can be decreased when combined with Midostaurin.Approved, Investigational
MifepristoneThe serum concentration of Acetyl sulfisoxazole can be increased when it is combined with Mifepristone.Approved, Investigational
MirabegronThe metabolism of Mirabegron can be decreased when combined with Acetyl sulfisoxazole.Approved
MirtazapineThe metabolism of Mirtazapine can be decreased when combined with Acetyl sulfisoxazole.Approved
MoclobemideThe metabolism of Moclobemide can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
ModafinilThe metabolism of Modafinil can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
MontelukastThe metabolism of Montelukast can be decreased when combined with Acetyl sulfisoxazole.Approved
MorphineThe metabolism of Morphine can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
Mycophenolate mofetilThe metabolism of Mycophenolate mofetil can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
NabiloneThe metabolism of Acetyl sulfisoxazole can be decreased when combined with Nabilone.Approved, Investigational
NabiximolsThe metabolism of Nabiximols can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Acetyl sulfisoxazole.Approved
NaloxoneThe metabolism of Naloxone can be decreased when combined with Acetyl sulfisoxazole.Approved, Vet Approved
NaproxenThe metabolism of Naproxen can be decreased when combined with Acetyl sulfisoxazole.Approved, Vet Approved
NateglinideThe metabolism of Nateglinide can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
NefazodoneThe metabolism of Nefazodone can be decreased when combined with Acetyl sulfisoxazole.Approved, Withdrawn
NelfinavirThe metabolism of Nelfinavir can be decreased when combined with Acetyl sulfisoxazole.Approved
NeratinibThe metabolism of Neratinib can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
NetupitantThe metabolism of Netupitant can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
NevirapineThe metabolism of Nevirapine can be decreased when combined with Acetyl sulfisoxazole.Approved
NicardipineThe metabolism of Acetyl sulfisoxazole can be decreased when combined with Nicardipine.Approved, Investigational
NicergolineThe risk or severity of adverse effects can be increased when Nicergoline is combined with Acetyl sulfisoxazole.Approved, Investigational
NiclosamideThe metabolism of Niclosamide can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational, Vet Approved
NicotineThe metabolism of Nicotine can be decreased when combined with Acetyl sulfisoxazole.Approved
NifedipineThe metabolism of Nifedipine can be decreased when combined with Acetyl sulfisoxazole.Approved
NilotinibThe metabolism of Nilotinib can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
NilvadipineThe metabolism of Nilvadipine can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Acetyl sulfisoxazole.Approved, Investigational
NisoldipineThe metabolism of Nisoldipine can be decreased when combined with Acetyl sulfisoxazole.Approved
NitrazepamThe metabolism of Nitrazepam can be decreased when combined with Acetyl sulfisoxazole.Approved
NitrendipineThe metabolism of Nitrendipine can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
NorethisteroneThe metabolism of Norethisterone can be decreased when combined with Acetyl sulfisoxazole.Approved
NorgestrelThe metabolism of Norgestrel can be decreased when combined with Acetyl sulfisoxazole.Approved
NortriptylineThe metabolism of Nortriptyline can be decreased when combined with Acetyl sulfisoxazole.Approved
OdanacatibThe metabolism of Odanacatib can be decreased when combined with Acetyl sulfisoxazole.Investigational
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Acetyl sulfisoxazole.Approved
OlodaterolThe metabolism of Olodaterol can be decreased when combined with Acetyl sulfisoxazole.Approved
OlopatadineThe metabolism of Olopatadine can be decreased when combined with Acetyl sulfisoxazole.Approved
OmeprazoleThe metabolism of Omeprazole can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational, Vet Approved
OndansetronThe metabolism of Ondansetron can be decreased when combined with Acetyl sulfisoxazole.Approved
OpiumThe metabolism of Opium can be decreased when combined with Acetyl sulfisoxazole.Approved, Illicit
OrphenadrineThe metabolism of Orphenadrine can be decreased when combined with Acetyl sulfisoxazole.Approved
OspemifeneThe serum concentration of Ospemifene can be increased when it is combined with Acetyl sulfisoxazole.Approved, Investigational
OxaprozinThe metabolism of Oxaprozin can be decreased when combined with Acetyl sulfisoxazole.Approved
OxazepamThe metabolism of Oxazepam can be decreased when combined with Acetyl sulfisoxazole.Approved
OxybutyninThe metabolism of Oxybutynin can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
OxycodoneThe risk or severity of adverse effects can be increased when Acetyl sulfisoxazole is combined with Oxycodone.Approved, Illicit, Investigational
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational, Vet Approved
PaclitaxelThe metabolism of Paclitaxel can be decreased when combined with Acetyl sulfisoxazole.Approved, Vet Approved
PalbociclibThe metabolism of Palbociclib can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
PanobinostatThe metabolism of Panobinostat can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
PantoprazoleThe metabolism of Pantoprazole can be decreased when combined with Acetyl sulfisoxazole.Approved
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Acetyl sulfisoxazole.Approved
ParamethasoneThe metabolism of Paramethasone can be decreased when combined with Acetyl sulfisoxazole.Approved
ParecoxibThe serum concentration of Parecoxib can be increased when it is combined with Acetyl sulfisoxazole.Approved
ParicalcitolThe metabolism of Paricalcitol can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
ParitaprevirThe metabolism of Paritaprevir can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
PazopanibThe metabolism of Pazopanib can be decreased when combined with Acetyl sulfisoxazole.Approved
PentamidineThe metabolism of Pentamidine can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
PerampanelThe metabolism of Perampanel can be decreased when combined with Acetyl sulfisoxazole.Approved
PergolideThe risk or severity of adverse effects can be increased when Pergolide is combined with Acetyl sulfisoxazole.Approved, Investigational, Vet Approved, Withdrawn
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
PermethrinThe metabolism of Permethrin can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
PerospironeThe metabolism of Perospirone can be decreased when combined with Acetyl sulfisoxazole.Approved
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Acetyl sulfisoxazole.Approved
PethidineThe metabolism of Pethidine can be decreased when combined with Acetyl sulfisoxazole.Approved
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Acetyl sulfisoxazole.Withdrawn
PhenobarbitalThe metabolism of Acetyl sulfisoxazole can be increased when combined with Phenobarbital.Approved, Investigational
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be decreased when combined with Acetyl sulfisoxazole.Approved
PhenprocoumonThe metabolism of Phenprocoumon can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
PhenylbutazoneThe metabolism of Phenylbutazone can be decreased when combined with Acetyl sulfisoxazole.Approved, Vet Approved
PhenytoinThe metabolism of Acetyl sulfisoxazole can be increased when combined with Phenytoin.Approved, Vet Approved
PilocarpineThe metabolism of Pilocarpine can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
PimecrolimusThe metabolism of Pimecrolimus can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
PimozideThe serum concentration of Pimozide can be increased when it is combined with Acetyl sulfisoxazole.Approved
PinacidilThe metabolism of Pinacidil can be decreased when combined with Acetyl sulfisoxazole.Approved
PioglitazoneThe metabolism of Pioglitazone can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
PiperaquineThe metabolism of Piperaquine can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
PiroxicamThe metabolism of Piroxicam can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Acetyl sulfisoxazole.Approved
PitolisantThe metabolism of Pitolisant can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
PodofiloxThe metabolism of Podofilox can be decreased when combined with Acetyl sulfisoxazole.Approved
PomalidomideThe metabolism of Pomalidomide can be decreased when combined with Acetyl sulfisoxazole.Approved
PonatinibThe metabolism of Ponatinib can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
PosaconazoleThe metabolism of Posaconazole can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational, Vet Approved
PrasteroneThe metabolism of Prasterone can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational, Nutraceutical
PrasugrelThe metabolism of Prasugrel can be decreased when combined with Acetyl sulfisoxazole.Approved
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Acetyl sulfisoxazole.Approved
PrazepamThe metabolism of Prazepam can be decreased when combined with Acetyl sulfisoxazole.Approved, Illicit
PraziquantelThe metabolism of Praziquantel can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational, Vet Approved
PrednisoloneThe metabolism of Prednisolone can be decreased when combined with Acetyl sulfisoxazole.Approved, Vet Approved
PrednisoneThe metabolism of Prednisone can be decreased when combined with Acetyl sulfisoxazole.Approved, Vet Approved
PrimaquineThe metabolism of Primaquine can be decreased when combined with Acetyl sulfisoxazole.Approved
PrimidoneThe metabolism of Acetyl sulfisoxazole can be increased when combined with Primidone.Approved, Vet Approved
ProchlorperazineThe metabolism of Prochlorperazine can be decreased when combined with Acetyl sulfisoxazole.Approved, Vet Approved
ProgesteroneThe metabolism of Progesterone can be decreased when combined with Acetyl sulfisoxazole.Approved, Vet Approved
ProguanilThe metabolism of Proguanil can be decreased when combined with Acetyl sulfisoxazole.Approved
PromazineThe metabolism of Promazine can be decreased when combined with Acetyl sulfisoxazole.Approved, Vet Approved
PropafenoneThe serum concentration of Propafenone can be increased when it is combined with Acetyl sulfisoxazole.Approved
PropiverineThe metabolism of Propiverine can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
PropofolThe metabolism of Propofol can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational, Vet Approved
PropranololThe metabolism of Propranolol can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
PyrazinamideThe metabolism of Pyrazinamide can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
PyrimethamineThe metabolism of Acetyl sulfisoxazole can be decreased when combined with Pyrimethamine.Approved, Investigational, Vet Approved
QuazepamThe metabolism of Quazepam can be decreased when combined with Acetyl sulfisoxazole.Approved, Illicit
QuetiapineThe metabolism of Quetiapine can be decreased when combined with Acetyl sulfisoxazole.Approved
QuinacrineThe metabolism of Quinacrine can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
QuinidineThe metabolism of Quinidine can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
QuinineThe metabolism of Quinine can be decreased when combined with Acetyl sulfisoxazole.Approved
RabeprazoleThe metabolism of Rabeprazole can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
RaloxifeneThe metabolism of Raloxifene can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
RamelteonThe serum concentration of Ramelteon can be increased when it is combined with Acetyl sulfisoxazole.Approved, Investigational
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Acetyl sulfisoxazole.Approved, Investigational
ReboxetineThe metabolism of Reboxetine can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
RegorafenibThe metabolism of Regorafenib can be decreased when combined with Acetyl sulfisoxazole.Approved
RepaglinideThe metabolism of Repaglinide can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
RetapamulinThe metabolism of Retapamulin can be decreased when combined with Acetyl sulfisoxazole.Approved
RifabutinThe metabolism of Rifabutin can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
RifampicinThe metabolism of Acetyl sulfisoxazole can be increased when combined with Rifampicin.Approved
RifapentineThe metabolism of Acetyl sulfisoxazole can be increased when combined with Rifapentine.Approved, Investigational
RilpivirineThe serum concentration of Rilpivirine can be increased when it is combined with Acetyl sulfisoxazole.Approved
RimonabantThe metabolism of Rimonabant can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
RiociguatThe metabolism of Riociguat can be decreased when combined with Acetyl sulfisoxazole.Approved
RisperidoneThe metabolism of Risperidone can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
RitonavirThe metabolism of Ritonavir can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
RivaroxabanThe metabolism of Rivaroxaban can be decreased when combined with Acetyl sulfisoxazole.Approved
RofecoxibThe metabolism of Rofecoxib can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational, Withdrawn
RolapitantThe metabolism of Rolapitant can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
RomidepsinThe metabolism of Romidepsin can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
RopiniroleThe metabolism of Ropinirole can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Acetyl sulfisoxazole.Approved
RosiglitazoneThe metabolism of Rosiglitazone can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
RosuvastatinThe serum concentration of Rosuvastatin can be increased when it is combined with Acetyl sulfisoxazole.Approved
RotigotineThe metabolism of Rotigotine can be decreased when combined with Acetyl sulfisoxazole.Approved
RoxithromycinThe metabolism of Roxithromycin can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational, Withdrawn
RucaparibThe metabolism of Rucaparib can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
RupatadineThe metabolism of Rupatadine can be decreased when combined with Acetyl sulfisoxazole.Approved
RuxolitinibThe metabolism of Ruxolitinib can be decreased when combined with Acetyl sulfisoxazole.Approved
SafinamideThe metabolism of Safinamide can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
Salicylic acidThe metabolism of Salicylic acid can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational, Vet Approved
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Acetyl sulfisoxazole.Approved
SaquinavirThe metabolism of Saquinavir can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Acetyl sulfisoxazole.Approved
SecobarbitalThe metabolism of Acetyl sulfisoxazole can be increased when combined with Secobarbital.Approved, Vet Approved
SelegilineThe metabolism of Selegiline can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational, Vet Approved
SelexipagThe metabolism of Selexipag can be decreased when combined with Acetyl sulfisoxazole.Approved
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Acetyl sulfisoxazole.Approved
SertindoleThe metabolism of Sertindole can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational, Withdrawn
SertralineThe metabolism of Sertraline can be decreased when combined with Acetyl sulfisoxazole.Approved
SevofluraneThe metabolism of Sevoflurane can be decreased when combined with Acetyl sulfisoxazole.Approved, Vet Approved
SibutramineThe metabolism of Sibutramine can be decreased when combined with Acetyl sulfisoxazole.Approved, Illicit, Investigational, Withdrawn
SildenafilThe metabolism of Sildenafil can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
SilodosinThe metabolism of Silodosin can be decreased when combined with Acetyl sulfisoxazole.Approved
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Acetyl sulfisoxazole.Approved
SirolimusThe metabolism of Sirolimus can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
SitagliptinThe metabolism of Sitagliptin can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
SitaxentanThe metabolism of Sitaxentan can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational, Withdrawn
SolifenacinThe metabolism of Solifenacin can be decreased when combined with Acetyl sulfisoxazole.Approved
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Acetyl sulfisoxazole.Approved, Investigational
SorafenibThe metabolism of Sorafenib can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
SpiramycinThe metabolism of Spiramycin can be decreased when combined with Acetyl sulfisoxazole.Approved
SufentanilThe metabolism of Sufentanil can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
SulfadiazineThe metabolism of Acetyl sulfisoxazole can be decreased when combined with Sulfadiazine.Approved, Investigational, Vet Approved
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be decreased when combined with Acetyl sulfisoxazole.Approved
SulfamoxoleThe metabolism of Sulfamoxole can be decreased when combined with Acetyl sulfisoxazole.Approved
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be decreased when combined with Acetyl sulfisoxazole.Approved
SulfisoxazoleThe metabolism of Acetyl sulfisoxazole can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
SunitinibThe metabolism of Sunitinib can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
SuprofenThe metabolism of Suprofen can be decreased when combined with Acetyl sulfisoxazole.Approved, Withdrawn
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Acetyl sulfisoxazole.Approved, Investigational
Synthetic Conjugated Estrogens, AThe metabolism of Synthetic Conjugated Estrogens, A can be decreased when combined with Acetyl sulfisoxazole.Approved
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be decreased when combined with Acetyl sulfisoxazole.Approved
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
TadalafilThe metabolism of Tadalafil can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
TamoxifenThe metabolism of Tamoxifen can be decreased when combined with Acetyl sulfisoxazole.Approved
TamsulosinThe metabolism of Tamsulosin can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
TapentadolThe metabolism of Tapentadol can be decreased when combined with Acetyl sulfisoxazole.Approved
TasosartanThe metabolism of Tasosartan can be decreased when combined with Acetyl sulfisoxazole.Approved
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be decreased when combined with Acetyl sulfisoxazole.Experimental
TelaprevirThe metabolism of Telaprevir can be decreased when combined with Acetyl sulfisoxazole.Approved, Withdrawn
TelithromycinThe metabolism of Telithromycin can be decreased when combined with Acetyl sulfisoxazole.Approved
TemazepamThe metabolism of Temazepam can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
TemsirolimusThe metabolism of Temsirolimus can be decreased when combined with Acetyl sulfisoxazole.Approved
TeniposideThe metabolism of Teniposide can be decreased when combined with Acetyl sulfisoxazole.Approved
TenoxicamThe metabolism of Tenoxicam can be decreased when combined with Acetyl sulfisoxazole.Approved
TerbinafineThe metabolism of Terbinafine can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational, Vet Approved
TerfenadineThe metabolism of Terfenadine can be decreased when combined with Acetyl sulfisoxazole.Approved, Withdrawn
TergurideThe risk or severity of adverse effects can be increased when Terguride is combined with Acetyl sulfisoxazole.Experimental
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Acetyl sulfisoxazole.Investigational
TestosteroneThe metabolism of Testosterone can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
Testosterone cypionateThe metabolism of Testosterone cypionate can be decreased when combined with Acetyl sulfisoxazole.Approved
Testosterone enanthateThe metabolism of Testosterone enanthate can be decreased when combined with Acetyl sulfisoxazole.Approved
Testosterone propionateThe metabolism of Testosterone propionate can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational, Vet Approved, Withdrawn
Testosterone undecanoateThe metabolism of Testosterone undecanoate can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
TetracyclineThe metabolism of Tetracycline can be decreased when combined with Acetyl sulfisoxazole.Approved, Vet Approved
TezacaftorThe metabolism of Tezacaftor can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
ThalidomideThe metabolism of Thalidomide can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational, Withdrawn
TheophyllineThe metabolism of Theophylline can be decreased when combined with Acetyl sulfisoxazole.Approved
ThiamylalThe metabolism of Thiamylal can be decreased when combined with Acetyl sulfisoxazole.Approved, Vet Approved
ThiotepaThe metabolism of Thiotepa can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
TiagabineThe metabolism of Tiagabine can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
TicagrelorThe metabolism of Ticagrelor can be decreased when combined with Acetyl sulfisoxazole.Approved
TiclopidineThe metabolism of Ticlopidine can be decreased when combined with Acetyl sulfisoxazole.Approved
TinidazoleThe metabolism of Tinidazole can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Acetyl sulfisoxazole.Approved
TipranavirThe metabolism of Tipranavir can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
TocofersolanThe metabolism of Tocofersolan can be decreased when combined with Acetyl sulfisoxazole.Approved
TocopherolThe metabolism of Tocopherol can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
TofacitinibThe metabolism of Tofacitinib can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
TolbutamideThe metabolism of Acetyl sulfisoxazole can be decreased when combined with Tolbutamide.Approved, Investigational
TolterodineThe metabolism of Tolterodine can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Acetyl sulfisoxazole.Approved
TopiroxostatThe metabolism of Acetyl sulfisoxazole can be decreased when combined with Topiroxostat.Approved, Investigational
TorasemideThe metabolism of Torasemide can be decreased when combined with Acetyl sulfisoxazole.Approved
ToremifeneThe metabolism of Toremifene can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
TrabectedinThe metabolism of Trabectedin can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
TramadolThe metabolism of Tramadol can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
Trastuzumab emtansineThe metabolism of Trastuzumab emtansine can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
TrazodoneThe metabolism of Trazodone can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
TreprostinilThe metabolism of Treprostinil can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
TretinoinThe metabolism of Tretinoin can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational, Nutraceutical
TriamcinoloneThe metabolism of Triamcinolone can be decreased when combined with Acetyl sulfisoxazole.Approved, Vet Approved
TriazolamThe metabolism of Triazolam can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Acetyl sulfisoxazole.Approved
TrimethoprimThe metabolism of Trimethoprim can be decreased when combined with Acetyl sulfisoxazole.Approved, Vet Approved
TrimipramineThe metabolism of Trimipramine can be decreased when combined with Acetyl sulfisoxazole.Approved
TroglitazoneThe metabolism of Troglitazone can be decreased when combined with Acetyl sulfisoxazole.Investigational, Withdrawn
TroleandomycinThe metabolism of Troleandomycin can be decreased when combined with Acetyl sulfisoxazole.Approved
UdenafilThe metabolism of Udenafil can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Acetyl sulfisoxazole.Approved
ValbenazineThe metabolism of Valbenazine can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
ValdecoxibThe metabolism of Valdecoxib can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational, Withdrawn
Valproic AcidThe metabolism of Valproic Acid can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
ValsartanThe metabolism of Valsartan can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
VandetanibThe metabolism of Vandetanib can be decreased when combined with Acetyl sulfisoxazole.Approved
VanoxerineThe metabolism of Vanoxerine can be decreased when combined with Acetyl sulfisoxazole.Investigational
VardenafilThe metabolism of Vardenafil can be decreased when combined with Acetyl sulfisoxazole.Approved
VelpatasvirThe metabolism of Velpatasvir can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
VemurafenibThe metabolism of Vemurafenib can be decreased when combined with Acetyl sulfisoxazole.Approved
VenetoclaxThe metabolism of Venetoclax can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
VenlafaxineThe metabolism of Venlafaxine can be decreased when combined with Acetyl sulfisoxazole.Approved
VerapamilThe metabolism of Verapamil can be decreased when combined with Acetyl sulfisoxazole.Approved
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Acetyl sulfisoxazole.Investigational
VilanterolThe metabolism of Vilanterol can be decreased when combined with Acetyl sulfisoxazole.Approved
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Acetyl sulfisoxazole.Approved
VinblastineThe metabolism of Vinblastine can be decreased when combined with Acetyl sulfisoxazole.Approved
VincristineThe metabolism of Vincristine can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
VindesineThe serum concentration of Vindesine can be increased when it is combined with Acetyl sulfisoxazole.Approved, Investigational
VinflunineThe metabolism of Vinflunine can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
VismodegibThe metabolism of Vismodegib can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
VoriconazoleThe metabolism of Voriconazole can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
VoxilaprevirThe metabolism of Voxilaprevir can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
WarfarinThe metabolism of Warfarin can be decreased when combined with Acetyl sulfisoxazole.Approved
XimelagatranThe metabolism of Ximelagatran can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational, Withdrawn
YohimbineThe metabolism of Yohimbine can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational, Vet Approved
ZafirlukastThe metabolism of Zafirlukast can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
ZaleplonThe metabolism of Zaleplon can be decreased when combined with Acetyl sulfisoxazole.Approved, Illicit, Investigational
ZaltoprofenThe metabolism of Zaltoprofen can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
ZidovudineThe metabolism of Zidovudine can be decreased when combined with Acetyl sulfisoxazole.Approved
ZileutonThe metabolism of Zileuton can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational, Withdrawn
ZiprasidoneThe metabolism of Ziprasidone can be decreased when combined with Acetyl sulfisoxazole.Approved
ZolpidemThe metabolism of Zolpidem can be decreased when combined with Acetyl sulfisoxazole.Approved
ZomepiracThe metabolism of Zomepirac can be decreased when combined with Acetyl sulfisoxazole.Withdrawn
ZonisamideThe metabolism of Zonisamide can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Acetyl sulfisoxazole.Approved
ZotepineThe metabolism of Zotepine can be decreased when combined with Acetyl sulfisoxazole.Approved, Investigational, Withdrawn
ZuclopenthixolThe serum concentration of Zuclopenthixol can be increased when it is combined with Acetyl sulfisoxazole.Approved, Investigational
Food Interactions
Not Available

References

General References
  1. Suber RL, Lee C, Torosian G, Edds GT: Pharmacokinetics of sulfisoxazole compared in humans and two monogastric animal species. J Pharm Sci. 1981 Sep;70(9):981-4. [PubMed:6101167]
  2. Acetyl Sulfisoxazole [Link]
  3. ERYTHROMYCIN ETHYLSUCCINATE AND SULFISOXAZOLE ACETYL [Link]
  4. Sulfisoxazole [Link]
  5. Sulfadiazine or Sulfisoxazole [Link]
  6. Sulfisoxazole [Link]
  7. Comparison of the disposition of total and unbound sulfisoxazole after single and multiple dosing [Link]
  8. Gantrisin [Link]
  9. Gantrisin Description [Link]
  10. Sulfisoxazole, ToxNET [Link]
  11. Sulfisoxazole [Link]
External Links
PubChem Compound
6662
ChemSpider
6410
ChEBI
135975
ChEMBL
CHEMBL1200910
ATC Codes
G01AE10 — Combinations of sulfonamides
MSDS
Download (200 KB)

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
Granule, for suspensionOral
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)192 - 195 MSDS
Predicted Properties
PropertyValueSource
Water Solubility0.136 mg/mLALOGPS
logP1.02ALOGPS
logP0.72ChemAxon
logS-3.4ALOGPS
pKa (Strongest Acidic)18.1ChemAxon
pKa (Strongest Basic)1.61ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area106.5 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity77.48 m3·mol-1ChemAxon
Polarizability30.24 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as aminobenzenesulfonamides. These are organic compounds containing a benzenesulfonamide moiety with an amine group attached to the benzene ring.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Benzene and substituted derivatives
Sub Class
Benzenesulfonamides
Direct Parent
Aminobenzenesulfonamides
Alternative Parents
Benzenesulfonyl compounds / Aniline and substituted anilines / Organosulfonic acids and derivatives / Isoxazoles / Heteroaromatic compounds / Aminosulfonyl compounds / Acetamides / Amino acids and derivatives / Oxacyclic compounds / Azacyclic compounds
show 5 more
Substituents
Aminobenzenesulfonamide / Benzenesulfonyl group / Aniline or substituted anilines / Azole / Isoxazole / Organic sulfonic acid or derivatives / Organosulfonic acid or derivatives / Sulfonyl / Aminosulfonyl compound / Acetamide
show 18 more
Molecular Framework
Aromatic heteromonocyclic compounds
External Descriptors
Not Available

Targets

Kind
Protein
Organism
Escherichia coli (strain K12)
Pharmacological action
Yes
Actions
Inhibitor
General Function
Metal ion binding
Specific Function
Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
Gene Name
folP
Uniprot ID
P0AC13
Uniprot Name
Dihydropteroate synthase
Molecular Weight
30614.855 Da
References
  1. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
  2. Jorgensen JH, Crawford SA, Fiebelkorn KR: Susceptibility of Neisseria meningitidis to 16 antimicrobial agents and characterization of resistance mechanisms affecting some agents. J Clin Microbiol. 2005 Jul;43(7):3162-71. [PubMed:16000430]
  3. Fiebelkorn KR, Crawford SA, Jorgensen JH: Mutations in folP associated with elevated sulfonamide MICs for Neisseria meningitidis clinical isolates from five continents. Antimicrob Agents Chemother. 2005 Feb;49(2):536-40. [PubMed:15673729]
  4. Hong YL, Hossler PA, Calhoun DH, Meshnick SR: Inhibition of recombinant Pneumocystis carinii dihydropteroate synthetase by sulfa drugs. Antimicrob Agents Chemother. 1995 Aug;39(8):1756-63. [PubMed:7486915]
  5. Sulfisoxazole [Link]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
Inhibitor
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2C9
Uniprot ID
P11712
Uniprot Name
Cytochrome P450 2C9
Molecular Weight
55627.365 Da
References
  1. Komatsu K, Ito K, Nakajima Y, Kanamitsu Si, Imaoka S, Funae Y, Green CE, Tyson CA, Shimada N, Sugiyama Y: Prediction of in vivo drug-drug interactions between tolbutamide and various sulfonamides in humans based on in vitro experiments. Drug Metab Dispos. 2000 Apr;28(4):475-81. [PubMed:10725317]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da

Drug created on May 17, 2018 11:14 / Updated on June 06, 2018 05:05