Identification

Name
Chlorthalidone
Accession Number
DB00310  (APRD00127)
Type
Small Molecule
Groups
Approved
Description

A benzenesulfonamide-phthalimidine that tautomerizes to a benzophenones form. It is considered a thiazide-like diuretic. [PubChem]

Structure
Thumb
Synonyms
  • 1-keto-3-(3'-Sulfamyl-4'-chlorophenyl)-3-hydroxyisoindoline
  • 1-oxo-3-(3-Sulfamyl-4-chlorophenyl)-3-hydroxyisoindoline
  • 2-chloro-5-(1-Hydroxy-3-oxo-1-isoindolinyl)benzenesulfonamide
  • 2-chloro-5-(2,3-dihydro-1-Hydroxy-3-oxo-1H-isoindol-1-yl)benzenesulfonamide
  • 3-(4'-chloro-3'-Sulfamoylphenyl)-3-hydroxyphthalimidine
  • 3-Hydroxy-3-(4-chloro-3-sulfamylphenyl)phthalimidine
  • Chlorphthalidolone
  • Chlortalidone
  • Chlorthalidone
  • Phthalamodine
  • Phthalamudine
Product Images
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo Chlorthalidone Tab 100mgTablet100 mgOralApotex Corporation1976-12-31Not applicableCanada
ChlorthalidoneTablet50 mgOralAa Pharma Inc1976-12-31Not applicableCanada
Chlorthalidone 100mg TabletsTablet100 mgOralLaboratoires Confab IncNot applicableNot applicableCanada
Chlorthalidone 50mg TabletsTablet50 mgOralLaboratoires Confab IncNot applicableNot applicableCanada
Chlorthalidone Tab 100mgTablet100 mgOralPro Doc Limitee1978-12-311999-08-12Canada
Chlorthalidone Tab 100mgTablet100 mgOralDuchesnay Inc.1978-12-312003-07-18Canada
Chlorthalidone Tab 50mgTablet50 mgOralDuchesnay Inc.1978-12-312003-07-18Canada
Chlorthalidone Tab 50mgTablet50 mgOralPro Doc Limitee1978-12-311999-08-12Canada
Hygroton 50mgTablet50 mgOralNovartis1968-12-311999-08-04Canada
ThalitoneTablet15 mg/1OralMonarch Pharmaceuticals, Inc.1988-12-20Not applicableUs
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
ChlorthalidoneTablet50 mg/1OralIngenus Pharmaceuticals Nj, Llc2017-05-012018-05-11Us
ChlorthalidoneTablet25 mg/1OralRemedy Repack2017-09-19Not applicableUs
ChlorthalidoneTablet50 mg/1OralAphena Pharma Solutions Tennessee, Inc.1981-02-26Not applicableUs
ChlorthalidoneTablet25 mg/1Oralbryant ranch prepack2017-05-17Not applicableUs
ChlorthalidoneTablet25 mg/1OralA S Medication Solutions1981-02-262017-06-20Us
ChlorthalidoneTablet25 mg/1OralPreferreed Pharmaceuticals Inc.2016-12-12Not applicableUs
ChlorthalidoneTablet50 mg/1OralAphena Pharma Solutions Tennessee, Inc.2016-02-12Not applicableUs
ChlorthalidoneTablet25 mg/1OralPd Rx Pharmaceuticals, Inc.2009-11-18Not applicableUs
ChlorthalidoneTablet25 mg/1OralRiconpharma Llc2017-05-012018-05-11Us
ChlorthalidoneTablet25 mg/1OralAphena Pharma Solutions Tennessee, Inc.2016-02-12Not applicableUs
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Apo-atenidoneChlorthalidone (25 mg) + Atenolol (50 mg)TabletOralApotex Corporation2004-08-12Not applicableCanada
Apo-atenidoneChlorthalidone (25 mg) + Atenolol (100 mg)TabletOralApotex Corporation2004-08-12Not applicableCanada
Atenolol and ChlorthalidoneChlorthalidone (25 mg/1) + Atenolol (50 mg/1)TabletOralMajor1993-04-292018-03-30Us
Atenolol and ChlorthalidoneChlorthalidone (25 mg/1) + Atenolol (50 mg/1)TabletOralAphena Pharma Solutions Tennessee, Inc.2013-03-28Not applicableUs
Atenolol and ChlorthalidoneChlorthalidone (25 mg/1) + Atenolol (50 mg/1)TabletOralAidarex Pharmaceuticals LLC1992-08-01Not applicableUs
Atenolol and ChlorthalidoneChlorthalidone (25 mg/1) + Atenolol (100 mg/1)TabletOralPhysicians Total Care, Inc.2005-05-05Not applicableUs
Atenolol and ChlorthalidoneChlorthalidone (25 mg/1) + Atenolol (50 mg/1)TabletOralAvera Mc Kennan Hospital2016-05-16Not applicableUs
Atenolol and ChlorthalidoneChlorthalidone (25 mg/1) + Atenolol (50 mg/1)TabletOralMutual Pharmaceutical1993-04-29Not applicableUs53489 0531 01 nlmimage10 cd22e6d7
Atenolol and ChlorthalidoneChlorthalidone (25 mg/1) + Atenolol (100 mg/1)TabletOralMylan Pharmaceuticals1993-10-31Not applicableUs
Atenolol and ChlorthalidoneChlorthalidone (25 mg/1) + Atenolol (100 mg/1)TabletOralbryant ranch prepack1992-08-01Not applicableUs
International/Other Brands
Hygroton (Novartis) / Saluretin (Balkanpharma)
Categories
UNII
Q0MQD1073Q
CAS number
77-36-1
Weight
Average: 338.766
Monoisotopic: 338.012805247
Chemical Formula
C14H11ClN2O4S
InChI Key
JIVPVXMEBJLZRO-UHFFFAOYSA-N
InChI
InChI=1S/C14H11ClN2O4S/c15-11-6-5-8(7-12(11)22(16,20)21)14(19)10-4-2-1-3-9(10)13(18)17-14/h1-7,19H,(H,17,18)(H2,16,20,21)
IUPAC Name
2-chloro-5-(1-hydroxy-3-oxo-2,3-dihydro-1H-isoindol-1-yl)benzene-1-sulfonamide
SMILES
NS(=O)(=O)C1=C(Cl)C=CC(=C1)C1(O)NC(=O)C2=CC=CC=C12

Pharmacology

Indication

For management of hypertension either as the sole therapeutic agent or to enhance the effect of other antihypertensive drugs in the more severe forms of hypertension.

Structured Indications
Not Available
Pharmacodynamics

Chlorthalidone, a monosulfonamyl diuretic, differs form other thiazide diuretics in that a double ring system is incorporated into its structure. Chlorthalidone is used alone or with atenolol in the management of hypertension and edema.

Mechanism of action

Chlorthalidone inhibits sodium ion transport across the renal tubular epithelium in the cortical diluting segment of the ascending limb of the loop of Henle. By increasing the delivery of sodium to the distal renal tubule, Chlorthalidone indirectly increases potassium excretion via the sodium-potassium exchange mechanism.

TargetActionsOrganism
ASolute carrier family 12 member 1
inhibitor
Human
Absorption

Absorbed relatively rapidly after oral administration.

Volume of distribution
Not Available
Protein binding

High (75% [58% to albumin])

Metabolism

Liver

Route of elimination

The major portion of the drug is excreted unchanged by the kidneys.

Half life

40 hours

Clearance
Not Available
Toxicity

Symptoms of overdose include nausea, weakness, dizziness and disturbances of electrolyte balance.

Affected organisms
  • Humans and other mammals
Pathways
PathwayCategory
Chlorthalidone Action PathwayDrug action
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
(4R)-limoneneThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with (4R)-limonene.Investigational
16-Bromoepiandrosterone16-Bromoepiandrosterone may increase the hypokalemic activities of Chlorthalidone.Investigational
19-norandrostenedione19-norandrostenedione may increase the hypokalemic activities of Chlorthalidone.Experimental, Illicit
1alpha-Hydroxyvitamin D5The risk or severity of hyperkalemia can be increased when 1alpha-Hydroxyvitamin D5 is combined with Chlorthalidone.Investigational
2,4-thiazolidinedioneThe therapeutic efficacy of 2,4-thiazolidinedione can be decreased when used in combination with Chlorthalidone.Investigational
5-androstenedione5-androstenedione may increase the hypokalemic activities of Chlorthalidone.Experimental, Illicit
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline may increase the hypotensive activities of Chlorthalidone.Experimental
AcarboseThe therapeutic efficacy of Acarbose can be decreased when used in combination with Chlorthalidone.Approved, Investigational
AcebutololChlorthalidone may increase the hypotensive activities of Acebutolol.Approved, Investigational
AceclofenacThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Aceclofenac.Approved, Investigational
AcemetacinThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Acemetacin.Approved, Experimental, Investigational
AcetohexamideThe therapeutic efficacy of Acetohexamide can be decreased when used in combination with Chlorthalidone.Approved, Investigational, Withdrawn
AcetyldigitoxinThe risk or severity of adverse effects can be increased when Chlorthalidone is combined with Acetyldigitoxin.Approved
AcetyldigoxinThe risk or severity of adverse effects can be increased when Chlorthalidone is combined with Acetyldigoxin.Experimental
Acetylsalicylic acidThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Acetylsalicylic acid.Approved, Vet Approved
AclidiniumThe serum concentration of Chlorthalidone can be increased when it is combined with Aclidinium.Approved
AdapaleneThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Adapalene.Approved
AICA ribonucleotideThe therapeutic efficacy of AICA ribonucleotide can be decreased when used in combination with Chlorthalidone.Experimental, Investigational
AlaproclateAlaproclate may increase the hyponatremic activities of Chlorthalidone.Experimental
AlclofenacThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Alclofenac.Approved, Withdrawn
AlclometasoneAlclometasone may increase the hypokalemic activities of Chlorthalidone.Approved
AlcuroniumThe serum concentration of Chlorthalidone can be increased when it is combined with Alcuronium.Experimental
AldesleukinThe risk or severity of adverse effects can be increased when Aldesleukin is combined with Chlorthalidone.Approved
AldosteroneAldosterone may increase the hypokalemic activities of Chlorthalidone.Experimental, Investigational
AlfacalcidolThe risk or severity of hyperkalemia can be increased when Alfacalcidol is combined with Chlorthalidone.Approved, Nutraceutical
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Chlorthalidone.Approved, Illicit
AlfuzosinAlfuzosin may increase the hypotensive activities of Chlorthalidone.Approved, Investigational
AliskirenChlorthalidone may increase the hypotensive activities of Aliskiren.Approved, Investigational
AllicinThe therapeutic efficacy of Allicin can be decreased when used in combination with Chlorthalidone.Investigational
AllopurinolThe risk of a hypersensitivity reaction to Allopurinol is increased when it is combined with Chlorthalidone.Approved
AlminoprofenThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Alminoprofen.Experimental
AlogliptinThe therapeutic efficacy of Alogliptin can be decreased when used in combination with Chlorthalidone.Approved
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Alphacetylmethadol is combined with Chlorthalidone.Experimental, Illicit
AlphaprodineThe risk or severity of adverse effects can be increased when Alphaprodine is combined with Chlorthalidone.Illicit
AlprenololChlorthalidone may increase the hypotensive activities of Alprenolol.Approved, Withdrawn
AmbrisentanChlorthalidone may increase the hypotensive activities of Ambrisentan.Approved, Investigational
AmcinonideAmcinonide may increase the hypokalemic activities of Chlorthalidone.Approved
AmifostineChlorthalidone may increase the hypotensive activities of Amifostine.Approved, Investigational
AmilorideThe risk or severity of adverse effects can be increased when Chlorthalidone is combined with Amiloride.Approved
AmiodaroneThe risk or severity of adverse effects can be increased when Amiodarone is combined with Chlorthalidone.Approved, Investigational
AmlodipineChlorthalidone may increase the hypotensive activities of Amlodipine.Approved
AmobarbitalAmobarbital may increase the orthostatic hypotensive activities of Chlorthalidone.Approved, Illicit
AmphetamineAmphetamine may increase the hypotensive activities of Chlorthalidone.Approved, Illicit, Investigational
Amphotericin BThe risk or severity of adverse effects can be increased when Amphotericin B is combined with Chlorthalidone.Approved, Investigational
Amyl NitriteThe risk or severity of adverse effects can be increased when Chlorthalidone is combined with Amyl Nitrite.Approved
AndrographolideThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Andrographolide.Investigational
AndrostenedioneAndrostenedione may increase the hypokalemic activities of Chlorthalidone.Experimental, Illicit
AnecortaveAnecortave may increase the hypokalemic activities of Chlorthalidone.Investigational
anecortave acetateanecortave acetate may increase the hypokalemic activities of Chlorthalidone.Investigational
AnisodamineThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Anisodamine.Investigational
Anisotropine MethylbromideThe serum concentration of Chlorthalidone can be increased when it is combined with Anisotropine Methylbromide.Approved
AntipyrineThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Antipyrine.Approved, Investigational
ApocyninThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Apocynin.Investigational
ApomorphineThe risk or severity of adverse effects can be increased when Apomorphine is combined with Chlorthalidone.Approved, Investigational
ApraclonidineThe risk or severity of adverse effects can be increased when Chlorthalidone is combined with Apraclonidine.Approved
ApremilastThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Apremilast.Approved, Investigational
ArbutamineArbutamine may increase the hypokalemic activities of Chlorthalidone.Approved
ArformoterolArformoterol may increase the hypokalemic activities of Chlorthalidone.Approved, Investigational
AripiprazoleAripiprazole may increase the hypotensive activities of Chlorthalidone.Approved, Investigational
ArotinololThe risk or severity of adverse effects can be increased when Arotinolol is combined with Chlorthalidone.Investigational
Arsenic trioxideThe risk or severity of adverse effects can be increased when Arsenic trioxide is combined with Chlorthalidone.Approved, Investigational
AtamestaneAtamestane may increase the hypokalemic activities of Chlorthalidone.Investigational
AtenololChlorthalidone may increase the hypotensive activities of Atenolol.Approved
AtracuriumThe serum concentration of Chlorthalidone can be increased when it is combined with Atracurium.Approved, Experimental, Investigational
Atracurium besylateThe serum concentration of Chlorthalidone can be increased when it is combined with Atracurium besylate.Approved
AtropineThe serum concentration of Chlorthalidone can be increased when it is combined with Atropine.Approved, Vet Approved
AvanafilAvanafil may increase the antihypertensive activities of Chlorthalidone.Approved
AzapropazoneThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Azapropazone.Withdrawn
AzelastineThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Azelastine.Approved
Azilsartan medoxomilThe risk or severity of adverse effects can be increased when Chlorthalidone is combined with Azilsartan medoxomil.Approved, Investigational
BalaglitazoneThe therapeutic efficacy of Balaglitazone can be decreased when used in combination with Chlorthalidone.Investigational
BalsalazideThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Balsalazide.Approved, Investigational
BambuterolBambuterol may increase the hypokalemic activities of Chlorthalidone.Approved, Investigational
BarbexacloneBarbexaclone may increase the orthostatic hypotensive activities of Chlorthalidone.Experimental
BarbitalBarbital may increase the orthostatic hypotensive activities of Chlorthalidone.Illicit
BarnidipineChlorthalidone may increase the antihypertensive activities of Barnidipine.Approved
Beclomethasone dipropionateBeclomethasone dipropionate may increase the hypokalemic activities of Chlorthalidone.Approved, Investigational
BecocalcidiolThe risk or severity of hyperkalemia can be increased when Becocalcidiol is combined with Chlorthalidone.Investigational
Bempedoic acidThe therapeutic efficacy of Bempedoic acid can be decreased when used in combination with Chlorthalidone.Investigational
BenactyzineThe serum concentration of Chlorthalidone can be increased when it is combined with Benactyzine.Withdrawn
BenazeprilThe risk or severity of hypotension can be increased when Chlorthalidone is combined with Benazepril.Approved, Investigational
BendazacThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Bendazac.Experimental
BendroflumethiazideChlorthalidone may increase the hypotensive activities of Bendroflumethiazide.Approved
BenmoxinBenmoxin may increase the hypotensive activities of Chlorthalidone.Withdrawn
BenorilateThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Benorilate.Experimental
BenoxaprofenThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Benoxaprofen.Withdrawn
BenzatropineThe serum concentration of Chlorthalidone can be increased when it is combined with Benzatropine.Approved
BenzydamineThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Benzydamine.Approved
BepridilChlorthalidone may increase the hypotensive activities of Bepridil.Approved, Withdrawn
BetamethasoneBetamethasone may increase the hypokalemic activities of Chlorthalidone.Approved, Vet Approved
BetaxololBetaxolol may increase the hypotensive activities of Chlorthalidone.Approved, Investigational
BethanidineBethanidine may increase the hypotensive activities of Chlorthalidone.Approved
BevoniumThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Bevonium.Experimental
BezitramideThe risk or severity of adverse effects can be increased when Bezitramide is combined with Chlorthalidone.Experimental, Illicit, Withdrawn
BietaserpineBietaserpine may increase the hypotensive activities of Chlorthalidone.Experimental
BimatoprostChlorthalidone may increase the hypotensive activities of Bimatoprost.Approved, Investigational
BiperidenThe serum concentration of Chlorthalidone can be increased when it is combined with Biperiden.Approved, Investigational
BisoprololChlorthalidone may increase the hypotensive activities of Bisoprolol.Approved
BornaprineThe serum concentration of Chlorthalidone can be increased when it is combined with Bornaprine.Experimental
BortezomibThe risk or severity of adverse effects can be increased when Bortezomib is combined with Chlorthalidone.Approved, Investigational
BosentanBosentan may increase the hypotensive activities of Chlorthalidone.Approved, Investigational
BQ-123Chlorthalidone may increase the hypotensive activities of BQ-123.Investigational
BretyliumChlorthalidone may increase the hypotensive activities of Bretylium.Approved
BrimonidineBrimonidine may increase the antihypertensive activities of Chlorthalidone.Approved
BrofaromineBrofaromine may increase the hypotensive activities of Chlorthalidone.Experimental
BromfenacThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Bromfenac.Approved
BromocriptineThe risk or severity of adverse effects can be increased when Bromocriptine is combined with Chlorthalidone.Approved, Investigational
BucillamineThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Bucillamine.Investigational
BudesonideBudesonide may increase the hypokalemic activities of Chlorthalidone.Approved
BufexamacThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Bufexamac.Approved, Experimental
BuforminThe therapeutic efficacy of Buformin can be decreased when used in combination with Chlorthalidone.Investigational, Withdrawn
BumadizoneThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Bumadizone.Experimental
BumetanideThe risk or severity of adverse effects can be increased when Chlorthalidone is combined with Bumetanide.Approved
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Chlorthalidone.Approved, Investigational
BupranololChlorthalidone may increase the hypotensive activities of Bupranolol.Approved
BuprenorphineThe risk or severity of adverse effects can be increased when Buprenorphine is combined with Chlorthalidone.Approved, Illicit, Investigational, Vet Approved
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Chlorthalidone.Approved, Illicit, Vet Approved
ButylscopolamineThe serum concentration of Chlorthalidone can be increased when it is combined with Butylscopolamine.Approved, Investigational, Vet Approved
CadralazineCadralazine may increase the hypotensive activities of Chlorthalidone.Experimental
CafedrineChlorthalidone may increase the hypotensive activities of Cafedrine.Investigational
CalcidiolThe risk or severity of hyperkalemia can be increased when Calcidiol is combined with Chlorthalidone.Approved, Nutraceutical
CalcipotriolThe risk or severity of hyperkalemia can be increased when Calcipotriol is combined with Chlorthalidone.Approved
CalcitriolThe risk or severity of hyperkalemia can be increased when Calcitriol is combined with Chlorthalidone.Approved, Nutraceutical
Calcium AcetateChlorthalidone may decrease the excretion rate of Calcium Acetate which could result in a higher serum level.Approved, Investigational
Calcium CarbonateChlorthalidone may decrease the excretion rate of Calcium Carbonate which could result in a higher serum level.Approved, Investigational
Calcium ChlorideChlorthalidone may decrease the excretion rate of Calcium Chloride which could result in a higher serum level.Approved
Calcium CitrateChlorthalidone may decrease the excretion rate of Calcium Citrate which could result in a higher serum level.Approved
Calcium glubionateChlorthalidone may decrease the excretion rate of Calcium glubionate which could result in a higher serum level.Approved
Calcium GluceptateChlorthalidone may decrease the excretion rate of Calcium Gluceptate which could result in a higher serum level.Approved
Calcium gluconateChlorthalidone may decrease the excretion rate of Calcium gluconate which could result in a higher serum level.Approved, Vet Approved
Calcium lactateChlorthalidone may decrease the excretion rate of Calcium lactate which could result in a higher serum level.Approved, Investigational, Vet Approved
Calcium lactate gluconateChlorthalidone may decrease the excretion rate of Calcium lactate gluconate which could result in a higher serum level.Experimental
Calcium levulinateChlorthalidone may decrease the excretion rate of Calcium levulinate which could result in a higher serum level.Approved, Experimental
Calcium pangamateChlorthalidone may decrease the excretion rate of Calcium pangamate which could result in a higher serum level.Experimental
Calcium PhosphateChlorthalidone may decrease the excretion rate of Calcium Phosphate which could result in a higher serum level.Approved
CanagliflozinThe therapeutic efficacy of Canagliflozin can be decreased when used in combination with Chlorthalidone.Approved
CandesartanChlorthalidone may increase the hypotensive activities of Candesartan.Experimental
Candesartan cilexetilThe risk or severity of hypotension can be increased when Candesartan cilexetil is combined with Chlorthalidone.Approved
CandoxatrilThe risk or severity of hypotension can be increased when Chlorthalidone is combined with Candoxatril.Experimental
CaptoprilThe risk or severity of hypotension can be increased when Chlorthalidone is combined with Captopril.Approved
CarbamazepineThe risk or severity of adverse effects can be increased when Chlorthalidone is combined with Carbamazepine.Approved, Investigational
Carbaspirin calciumThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Carbaspirin calcium.Experimental, Investigational
CarbetocinThe risk or severity of adverse effects can be increased when Carbetocin is combined with Chlorthalidone.Approved, Investigational
CarbutamideThe therapeutic efficacy of Carbutamide can be decreased when used in combination with Chlorthalidone.Experimental
CarfentanilThe risk or severity of adverse effects can be increased when Carfentanil is combined with Chlorthalidone.Illicit, Investigational, Vet Approved
CaroxazoneCaroxazone may increase the hypotensive activities of Chlorthalidone.Withdrawn
CarprofenThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Carprofen.Approved, Vet Approved, Withdrawn
CarteololChlorthalidone may increase the hypotensive activities of Carteolol.Approved
CarvedilolChlorthalidone may increase the hypotensive activities of Carvedilol.Approved, Investigational
CaseinChlorthalidone may decrease the excretion rate of Casein which could result in a higher serum level.Approved
CastanospermineThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Castanospermine.Experimental
CelecoxibThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Celecoxib.Approved, Investigational
CeliprololCeliprolol may increase the hypokalemic activities of Chlorthalidone.Approved, Investigational
ChloroquineThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Chloroquine.Approved, Investigational, Vet Approved
ChlorothiazideChlorthalidone may increase the hypotensive activities of Chlorothiazide.Approved, Vet Approved
ChlorphenoxamineThe serum concentration of Chlorthalidone can be increased when it is combined with Chlorphenoxamine.Withdrawn
ChlorpromazineThe risk or severity of adverse effects can be increased when Chlorpromazine is combined with Chlorthalidone.Approved, Investigational, Vet Approved
ChlorpropamideThe therapeutic efficacy of Chlorpropamide can be decreased when used in combination with Chlorthalidone.Approved, Investigational
CholecalciferolThe risk or severity of hyperkalemia can be increased when Cholecalciferol is combined with Chlorthalidone.Approved, Nutraceutical
CholestyramineCholestyramine can cause a decrease in the absorption of Chlorthalidone resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
Choline magnesium trisalicylateThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Choline magnesium trisalicylate.Approved
CiclesonideCiclesonide may increase the hypokalemic activities of Chlorthalidone.Approved, Investigational
CicletanineChlorthalidone may increase the hypotensive activities of Cicletanine.Investigational
CiglitazoneThe therapeutic efficacy of Ciglitazone can be decreased when used in combination with Chlorthalidone.Experimental
CilazaprilThe risk or severity of hypotension can be increased when Chlorthalidone is combined with Cilazapril.Approved
CilnidipineThe risk or severity of adverse effects can be increased when Cilnidipine is combined with Chlorthalidone.Approved, Investigational
CitalopramCitalopram may increase the hyponatremic activities of Chlorthalidone.Approved
ClenbuterolClenbuterol may increase the hypokalemic activities of Chlorthalidone.Approved, Investigational, Vet Approved
ClevidipineThe risk or severity of adverse effects can be increased when Chlorthalidone is combined with Clevidipine.Approved, Investigational
ClobetasolClobetasol may increase the hypokalemic activities of Chlorthalidone.Approved, Investigational
Clobetasol propionateClobetasol propionate may increase the hypokalemic activities of Chlorthalidone.Approved
ClobetasoneClobetasone may increase the hypokalemic activities of Chlorthalidone.Approved
ClocortoloneClocortolone may increase the hypokalemic activities of Chlorthalidone.Approved
ClofarabineThe risk or severity of adverse effects can be increased when Clofarabine is combined with Chlorthalidone.Approved, Investigational
ClomipramineThe risk or severity of adverse effects can be increased when Clomipramine is combined with Chlorthalidone.Approved, Investigational, Vet Approved
ClonidineClonidine may increase the hypotensive activities of Chlorthalidone.Approved
ClonixinThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Clonixin.Approved
CloranololChlorthalidone may increase the hypotensive activities of Cloranolol.Experimental
ClozapineThe risk or severity of adverse effects can be increased when Clozapine is combined with Chlorthalidone.Approved
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Chlorthalidone.Approved, Illicit
ColesevelamColesevelam can cause a decrease in the absorption of Chlorthalidone resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
ColestipolColestipol can cause a decrease in the absorption of Chlorthalidone resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
ConivaptanThe risk or severity of adverse effects can be increased when Conivaptan is combined with Chlorthalidone.Approved, Investigational
Cortexolone 17α-propionateCortexolone 17α-propionate may increase the hypokalemic activities of Chlorthalidone.Investigational
CorticosteroneCorticosterone may increase the hypokalemic activities of Chlorthalidone.Experimental
Cortisone acetateCortisone acetate may increase the hypokalemic activities of Chlorthalidone.Approved, Investigational
CryptenamineChlorthalidone may increase the hypotensive activities of Cryptenamine.Approved
CurcuminThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Curcumin.Approved, Investigational
CyclopenthiazideChlorthalidone may increase the hypotensive activities of Cyclopenthiazide.Experimental
CyclopentolateThe serum concentration of Chlorthalidone can be increased when it is combined with Cyclopentolate.Approved
CyclophosphamideThe risk or severity of severe leukopenia can be increased when Chlorthalidone is combined with Cyclophosphamide.Approved, Investigational
CyclothiazideChlorthalidone may increase the hypotensive activities of Cyclothiazide.Approved
CymarinThe risk or severity of adverse effects can be increased when Chlorthalidone is combined with Cymarin.Experimental
DapagliflozinThe risk or severity of adverse effects can be increased when Chlorthalidone is combined with Dapagliflozin.Approved
DapoxetineDapoxetine may increase the hyponatremic activities of Chlorthalidone.Investigational
DarifenacinThe serum concentration of Chlorthalidone can be increased when it is combined with Darifenacin.Approved, Investigational
DebrisoquinDebrisoquin may increase the hypotensive activities of Chlorthalidone.Approved, Investigational
DeflazacortDeflazacort may increase the hypokalemic activities of Chlorthalidone.Approved, Investigational
DelaprilThe risk or severity of hypotension can be increased when Chlorthalidone is combined with Delapril.Experimental
DeoxyspergualinThe therapeutic efficacy of Deoxyspergualin can be decreased when used in combination with Chlorthalidone.Investigational
DeserpidineChlorthalidone may increase the hypotensive activities of Deserpidine.Approved
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Chlorthalidone.Approved
DeslanosideThe risk or severity of adverse effects can be increased when Chlorthalidone is combined with Deslanoside.Approved
DesloratadineThe serum concentration of Chlorthalidone can be increased when it is combined with Desloratadine.Approved, Investigational
DesonideDesonide may increase the hypokalemic activities of Chlorthalidone.Approved, Investigational
DesoximetasoneDesoximetasone may increase the hypokalemic activities of Chlorthalidone.Approved
Desoxycorticosterone acetateDesoxycorticosterone acetate may increase the hypokalemic activities of Chlorthalidone.Approved
Desoxycorticosterone PivalateDesoxycorticosterone Pivalate may increase the hypokalemic activities of Chlorthalidone.Experimental, Vet Approved
DesvenlafaxineDesvenlafaxine may increase the hyponatremic activities of Chlorthalidone.Approved, Investigational
DexamethasoneDexamethasone may increase the hypokalemic activities of Chlorthalidone.Approved, Investigational, Vet Approved
Dexamethasone isonicotinateDexamethasone isonicotinate may increase the hypokalemic activities of Chlorthalidone.Vet Approved
DexetimideThe serum concentration of Chlorthalidone can be increased when it is combined with Dexetimide.Withdrawn
DexketoprofenThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Chlorthalidone.Approved, Investigational
DexmedetomidineThe risk or severity of adverse effects can be increased when Chlorthalidone is combined with Dexmedetomidine.Approved, Vet Approved
DextromoramideThe risk or severity of adverse effects can be increased when Dextromoramide is combined with Chlorthalidone.Experimental, Illicit
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Chlorthalidone.Approved, Illicit, Investigational, Withdrawn
DezocineThe risk or severity of adverse effects can be increased when Dezocine is combined with Chlorthalidone.Approved, Investigational
DiazoxideThe risk or severity of adverse effects can be increased when Chlorthalidone is combined with Diazoxide.Approved
DiclofenacThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Diclofenac.Approved, Vet Approved
DiclofenamideThe risk or severity of adverse effects can be increased when Chlorthalidone is combined with Diclofenamide.Approved, Investigational
DicyclomineThe serum concentration of Chlorthalidone can be increased when it is combined with Dicyclomine.Approved
DiethylnorspermineChlorthalidone may increase the hypotensive activities of Diethylnorspermine.Investigational
DifenpiramideThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Difenpiramide.Experimental
DiflorasoneDiflorasone may increase the hypokalemic activities of Chlorthalidone.Approved
DiflunisalThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Diflunisal.Approved, Investigational
DifluocortoloneDifluocortolone may increase the hypokalemic activities of Chlorthalidone.Approved, Investigational, Withdrawn
DifluprednateDifluprednate may increase the hypokalemic activities of Chlorthalidone.Approved
DigitoxinThe risk or severity of adverse effects can be increased when Chlorthalidone is combined with Digitoxin.Approved, Investigational
DigoxinThe risk or severity of adverse effects can be increased when Chlorthalidone is combined with Digoxin.Approved
Digoxin Immune Fab (Ovine)The risk or severity of adverse effects can be increased when Chlorthalidone is combined with Digoxin Immune Fab (Ovine).Approved
DihydralazineDihydralazine may increase the hypotensive activities of Chlorthalidone.Approved, Investigational
DihydrocodeineThe risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Chlorthalidone.Approved, Illicit
DihydroetorphineThe risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Chlorthalidone.Experimental, Illicit
DihydromorphineThe risk or severity of adverse effects can be increased when Dihydromorphine is combined with Chlorthalidone.Experimental, Illicit
DihydrotachysterolThe risk or severity of hyperkalemia can be increased when Dihydrotachysterol is combined with Chlorthalidone.Approved
DiltiazemChlorthalidone may increase the hypotensive activities of Diltiazem.Approved, Investigational
DinutuximabThe risk or severity of adverse effects can be increased when Chlorthalidone is combined with Dinutuximab.Approved, Investigational
DiphenhydramineThe serum concentration of Chlorthalidone can be increased when it is combined with Diphenhydramine.Approved, Investigational
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Chlorthalidone.Approved, Illicit
DipivefrinDipivefrin may increase the hypokalemic activities of Chlorthalidone.Approved
DipyridamoleThe risk or severity of adverse effects can be increased when Chlorthalidone is combined with Dipyridamole.Approved
DobutamineDobutamine may increase the hypokalemic activities of Chlorthalidone.Approved
DofetilideChlorthalidone may increase the QTc-prolonging activities of Dofetilide.Approved, Investigational
DorzolamideChlorthalidone may increase the hypotensive activities of Dorzolamide.Approved
DoxazosinDoxazosin may increase the hypotensive activities of Chlorthalidone.Approved
DoxercalciferolThe risk or severity of hyperkalemia can be increased when Doxercalciferol is combined with Chlorthalidone.Approved
DoxofyllineDoxofylline may increase the hypokalemic activities of Chlorthalidone.Approved, Investigational
DPDPEThe risk or severity of adverse effects can be increased when DPDPE is combined with Chlorthalidone.Experimental
DroxicamThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Droxicam.Withdrawn
DroxidopaDroxidopa may increase the hypokalemic activities of Chlorthalidone.Approved, Investigational
DulaglutideThe therapeutic efficacy of Dulaglutide can be decreased when used in combination with Chlorthalidone.Approved, Investigational
DuloxetineChlorthalidone may increase the orthostatic hypotensive activities of Duloxetine.Approved
DuvelisibThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Duvelisib.Investigational
E-6201The therapeutic efficacy of Chlorthalidone can be decreased when used in combination with E-6201.Investigational
EfonidipineChlorthalidone may increase the hypotensive activities of Efonidipine.Approved, Investigational
EldecalcitolThe risk or severity of hyperkalemia can be increased when Eldecalcitol is combined with Chlorthalidone.Investigational
ElocalcitolThe risk or severity of hyperkalemia can be increased when Elocalcitol is combined with Chlorthalidone.Investigational
EmeproniumThe serum concentration of Chlorthalidone can be increased when it is combined with Emepronium.Experimental
EmpagliflozinThe therapeutic efficacy of Empagliflozin can be decreased when used in combination with Chlorthalidone.Approved
EnalaprilThe risk or severity of hypotension can be increased when Chlorthalidone is combined with Enalapril.Approved, Vet Approved
EnalaprilatThe risk or severity of hypotension can be increased when Chlorthalidone is combined with Enalaprilat.Approved
EndralazineEndralazine may increase the hypotensive activities of Chlorthalidone.Experimental
EpanololChlorthalidone may increase the hypotensive activities of Epanolol.Experimental
EphedraEphedra may increase the hypokalemic activities of Chlorthalidone.Approved, Nutraceutical, Withdrawn
EpinephrineEpinephrine may increase the hypokalemic activities of Chlorthalidone.Approved, Vet Approved
EpirizoleThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Epirizole.Approved
EplerenoneThe risk or severity of adverse effects can be increased when Chlorthalidone is combined with Eplerenone.Approved
EpoprostenolChlorthalidone may increase the hypotensive activities of Epoprostenol.Approved
EprosartanChlorthalidone may increase the hypotensive activities of Eprosartan.Approved
EquileninEquilenin may increase the hypokalemic activities of Chlorthalidone.Experimental
EquilinEquilin may increase the hypokalemic activities of Chlorthalidone.Approved
ErgocalciferolThe risk or severity of hyperkalemia can be increased when Ergocalciferol is combined with Chlorthalidone.Approved, Nutraceutical
EscitalopramEscitalopram may increase the hyponatremic activities of Chlorthalidone.Approved, Investigational
EsmololThe risk or severity of adverse effects can be increased when Esmolol is combined with Chlorthalidone.Approved
EstroneEstrone may increase the hypokalemic activities of Chlorthalidone.Approved
Estrone sulfateEstrone sulfate may increase the hypokalemic activities of Chlorthalidone.Approved
Etacrynic acidThe risk or severity of adverse effects can be increased when Chlorthalidone is combined with Etacrynic acid.Approved, Investigational
EtafedrineEtafedrine may increase the hypokalemic activities of Chlorthalidone.Approved
EtanautineThe serum concentration of Chlorthalidone can be increased when it is combined with Etanautine.Experimental
EtanerceptThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Etanercept.Approved, Investigational
EthanolEthanol may increase the orthostatic hypotensive activities of Chlorthalidone.Approved
EthenzamideThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Ethenzamide.Experimental
EthopropazineThe serum concentration of Chlorthalidone can be increased when it is combined with Ethopropazine.Approved
EthylmorphineThe risk or severity of adverse effects can be increased when Ethylmorphine is combined with Chlorthalidone.Approved, Illicit
EtodolacThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Etodolac.Approved, Investigational, Vet Approved
EtofenamateThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Etofenamate.Approved, Investigational
EtoperidoneEtoperidone may increase the hyponatremic activities of Chlorthalidone.Withdrawn
EtoricoxibThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Etoricoxib.Approved, Investigational
EtorphineThe risk or severity of adverse effects can be increased when Etorphine is combined with Chlorthalidone.Illicit, Vet Approved
EtybenzatropineThe serum concentration of Chlorthalidone can be increased when it is combined with Etybenzatropine.Experimental
Evening primrose oilThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Evening primrose oil.Investigational, Nutraceutical
ExenatideThe therapeutic efficacy of Exenatide can be decreased when used in combination with Chlorthalidone.Approved, Investigational
ExisulindThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Exisulind.Investigational
FelbinacThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Felbinac.Experimental
FelodipineChlorthalidone may increase the hypotensive activities of Felodipine.Approved, Investigational
FenbufenThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Fenbufen.Approved
FenoldopamChlorthalidone may increase the hypotensive activities of Fenoldopam.Approved
FenoprofenThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Fenoprofen.Approved
FenoterolFenoterol may increase the hypokalemic activities of Chlorthalidone.Approved, Investigational
FentanylThe risk or severity of adverse effects can be increased when Fentanyl is combined with Chlorthalidone.Approved, Illicit, Investigational, Vet Approved
FentiazacThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Fentiazac.Experimental
FeprazoneThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Feprazone.Experimental
Ferulic acidThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Ferulic acid.Experimental
FesoterodineThe serum concentration of Chlorthalidone can be increased when it is combined with Fesoterodine.Approved
FimasartanThe risk or severity of adverse effects can be increased when Fimasartan is combined with Chlorthalidone.Approved, Investigational
FlavoxateThe serum concentration of Chlorthalidone can be increased when it is combined with Flavoxate.Approved
FloctafenineThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Floctafenine.Approved, Withdrawn
FluasteroneFluasterone may increase the hypokalemic activities of Chlorthalidone.Investigational
FludrocortisoneFludrocortisone may increase the hypokalemic activities of Chlorthalidone.Approved, Investigational
FlumethasoneFlumethasone may increase the hypokalemic activities of Chlorthalidone.Approved, Vet Approved
FlunisolideFlunisolide may increase the hypokalemic activities of Chlorthalidone.Approved, Investigational
FlunixinThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Flunixin.Vet Approved
FlunoxaprofenThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Flunoxaprofen.Experimental
Fluocinolone AcetonideFluocinolone Acetonide may increase the hypokalemic activities of Chlorthalidone.Approved, Investigational, Vet Approved
FluocinonideFluocinonide may increase the hypokalemic activities of Chlorthalidone.Approved, Investigational
FluocortoloneFluocortolone may increase the hypokalemic activities of Chlorthalidone.Approved, Withdrawn
FluorometholoneFluorometholone may increase the hypokalemic activities of Chlorthalidone.Approved, Investigational
FluoxetineFluoxetine may increase the hyponatremic activities of Chlorthalidone.Approved, Vet Approved
FluprednideneFluprednidene may increase the hypokalemic activities of Chlorthalidone.Approved, Withdrawn
FluprednisoloneFluprednisolone may increase the hypokalemic activities of Chlorthalidone.Approved
FlurandrenolideFlurandrenolide may increase the hypokalemic activities of Chlorthalidone.Approved
FlurbiprofenThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Flurbiprofen.Approved, Investigational
Fluticasone furoateFluticasone furoate may increase the hypokalemic activities of Chlorthalidone.Approved
Fluticasone propionateFluticasone propionate may increase the hypokalemic activities of Chlorthalidone.Approved
FluvoxamineFluvoxamine may increase the hyponatremic activities of Chlorthalidone.Approved, Investigational
FormestaneFormestane may increase the hypokalemic activities of Chlorthalidone.Approved, Investigational, Withdrawn
FormoterolFormoterol may increase the hypokalemic activities of Chlorthalidone.Approved, Investigational
FosinoprilThe risk or severity of hypotension can be increased when Chlorthalidone is combined with Fosinopril.Approved
FurazolidoneFurazolidone may increase the hypotensive activities of Chlorthalidone.Approved, Investigational, Vet Approved
FurosemideThe risk or severity of adverse effects can be increased when Chlorthalidone is combined with Furosemide.Approved, Vet Approved
GallamineThe serum concentration of Chlorthalidone can be increased when it is combined with Gallamine.Experimental
Gallamine TriethiodideThe serum concentration of Chlorthalidone can be increased when it is combined with Gallamine Triethiodide.Approved
GitoformateThe risk or severity of adverse effects can be increased when Chlorthalidone is combined with Gitoformate.Experimental
GlibornurideThe therapeutic efficacy of Glibornuride can be decreased when used in combination with Chlorthalidone.Investigational, Withdrawn
GliclazideThe therapeutic efficacy of Gliclazide can be decreased when used in combination with Chlorthalidone.Approved
GlimepirideThe therapeutic efficacy of Glimepiride can be decreased when used in combination with Chlorthalidone.Approved
GlipizideThe therapeutic efficacy of Glipizide can be decreased when used in combination with Chlorthalidone.Approved, Investigational
GliquidoneThe therapeutic efficacy of Gliquidone can be decreased when used in combination with Chlorthalidone.Approved, Investigational
GlyburideThe therapeutic efficacy of Glyburide can be decreased when used in combination with Chlorthalidone.Approved
GlycopyrroniumThe serum concentration of Chlorthalidone can be increased when it is combined with Glycopyrronium.Approved, Investigational, Vet Approved
GuacetisalThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Guacetisal.Experimental
GuanabenzChlorthalidone may increase the hypotensive activities of Guanabenz.Approved, Investigational
GuanadrelGuanadrel may increase the hypotensive activities of Chlorthalidone.Approved
GuanazodineChlorthalidone may increase the hypotensive activities of Guanazodine.Experimental
GuanethidineChlorthalidone may increase the hypotensive activities of Guanethidine.Approved
GuanfacineGuanfacine may increase the hypotensive activities of Chlorthalidone.Approved, Investigational
GuanoclorChlorthalidone may increase the hypotensive activities of Guanoclor.Experimental
GuanoxabenzChlorthalidone may increase the hypotensive activities of Guanoxabenz.Experimental
GuanoxanChlorthalidone may increase the hypotensive activities of Guanoxan.Experimental
GusperimusThe therapeutic efficacy of Gusperimus can be decreased when used in combination with Chlorthalidone.Investigational
HalcinonideHalcinonide may increase the hypokalemic activities of Chlorthalidone.Approved, Investigational, Withdrawn
HalothaneThe risk or severity of adverse effects can be increased when Halothane is combined with Chlorthalidone.Approved, Vet Approved
HarmalineHarmaline may increase the hypotensive activities of Chlorthalidone.Experimental
HE3286HE3286 may increase the hypokalemic activities of Chlorthalidone.Investigational
HeroinThe risk or severity of adverse effects can be increased when Heroin is combined with Chlorthalidone.Approved, Illicit, Investigational
HexamethoniumChlorthalidone may increase the hypotensive activities of Hexamethonium.Experimental
HexobarbitalHexobarbital may increase the orthostatic hypotensive activities of Chlorthalidone.Approved
HigenamineThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Higenamine.Investigational
HomatropineThe serum concentration of Chlorthalidone can be increased when it is combined with Homatropine.Approved
HydracarbazineHydracarbazine may increase the hypotensive activities of Chlorthalidone.Experimental
HydralazineHydralazine may increase the hypotensive activities of Chlorthalidone.Approved
HydrochlorothiazideChlorthalidone may increase the hypotensive activities of Hydrochlorothiazide.Approved, Vet Approved
HydrocodoneThe risk or severity of adverse effects can be increased when Hydrocodone is combined with Chlorthalidone.Approved, Illicit
HydrocortisoneHydrocortisone may increase the hypokalemic activities of Chlorthalidone.Approved, Vet Approved
HydroflumethiazideChlorthalidone may increase the hypotensive activities of Hydroflumethiazide.Approved, Investigational
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Chlorthalidone.Approved, Illicit
HyoscyamineThe serum concentration of Chlorthalidone can be increased when it is combined with Hyoscyamine.Approved
IbuprofenThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Ibuprofen.Approved
IbuproxamThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Ibuproxam.Withdrawn
IcatibantThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Icatibant.Approved, Investigational
IloprostThe risk or severity of adverse effects can be increased when Iloprost is combined with Chlorthalidone.Approved, Investigational
ImidaprilThe risk or severity of hypotension can be increased when Chlorthalidone is combined with Imidapril.Investigational
Imidazole salicylateThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Imidazole salicylate.Experimental
ImipramineThe risk or severity of adverse effects can be increased when Imipramine is combined with Chlorthalidone.Approved
IndacaterolIndacaterol may increase the hypokalemic activities of Chlorthalidone.Approved
IndalpineIndalpine may increase the hyponatremic activities of Chlorthalidone.Investigational, Withdrawn
IndapamideChlorthalidone may increase the hypotensive activities of Indapamide.Approved
IndenololChlorthalidone may increase the hypotensive activities of Indenolol.Withdrawn
IndobufenThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Indobufen.Investigational
IndomethacinThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Indomethacin.Approved, Investigational
IndoprofenThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Indoprofen.Withdrawn
IndoraminIndoramin may increase the hypotensive activities of Chlorthalidone.Withdrawn
InecalcitolThe risk or severity of hyperkalemia can be increased when Inecalcitol is combined with Chlorthalidone.Experimental, Investigational
Insulin AspartThe therapeutic efficacy of Insulin Aspart can be decreased when used in combination with Chlorthalidone.Approved
Insulin DetemirThe therapeutic efficacy of Insulin Detemir can be decreased when used in combination with Chlorthalidone.Approved
Insulin GlargineThe therapeutic efficacy of Insulin Glargine can be decreased when used in combination with Chlorthalidone.Approved
Insulin GlulisineThe therapeutic efficacy of Insulin Glulisine can be decreased when used in combination with Chlorthalidone.Approved
Insulin HumanThe therapeutic efficacy of Insulin Human can be decreased when used in combination with Chlorthalidone.Approved, Investigational
Insulin LisproThe therapeutic efficacy of Insulin Lispro can be decreased when used in combination with Chlorthalidone.Approved
Insulin PorkThe therapeutic efficacy of Insulin Pork can be decreased when used in combination with Chlorthalidone.Approved
Ipratropium bromideThe serum concentration of Chlorthalidone can be increased when it is combined with Ipratropium bromide.Approved
IproclozideIproclozide may increase the hypotensive activities of Chlorthalidone.Withdrawn
IproniazidIproniazid may increase the hypotensive activities of Chlorthalidone.Withdrawn
IrbesartanChlorthalidone may increase the hypotensive activities of Irbesartan.Approved, Investigational
IsocarboxazidIsocarboxazid may increase the hypotensive activities of Chlorthalidone.Approved
IsoetarineIsoetarine may increase the hypokalemic activities of Chlorthalidone.Approved
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Chlorthalidone.Approved, Vet Approved
IsoprenalineIsoprenaline may increase the hypokalemic activities of Chlorthalidone.Approved, Investigational
Isosorbide DinitrateThe risk or severity of adverse effects can be increased when Chlorthalidone is combined with Isosorbide Dinitrate.Approved, Investigational
Isosorbide MononitrateThe risk or severity of adverse effects can be increased when Chlorthalidone is combined with Isosorbide Mononitrate.Approved
IsoxicamThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Isoxicam.Withdrawn
IsoxsuprineThe risk or severity of adverse effects can be increased when Chlorthalidone is combined with Isoxsuprine.Approved, Withdrawn
IsradipineIsradipine may increase the hypotensive activities of Chlorthalidone.Approved, Investigational
IstaroximeIstaroxime may increase the hypokalemic activities of Chlorthalidone.Investigational
IvabradineChlorthalidone may increase the arrhythmogenic activities of Ivabradine.Approved
KebuzoneThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Kebuzone.Experimental
KetanserinKetanserin may increase the hypotensive activities of Chlorthalidone.Investigational
KetobemidoneThe risk or severity of adverse effects can be increased when Ketobemidone is combined with Chlorthalidone.Approved, Investigational
KetoprofenThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Ketoprofen.Approved, Vet Approved
KetorolacThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Ketorolac.Approved
LabetalolChlorthalidone may increase the hypotensive activities of Labetalol.Approved
LacidipineChlorthalidone may increase the hypotensive activities of Lacidipine.Approved, Investigational
Lanatoside CThe risk or severity of adverse effects can be increased when Chlorthalidone is combined with Lanatoside C.Experimental
LatanoprostChlorthalidone may increase the hypotensive activities of Latanoprost.Approved, Investigational
LeflunomideThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Leflunomide.Approved, Investigational
LercanidipineChlorthalidone may increase the hypotensive activities of Lercanidipine.Approved, Investigational
LevobunololThe risk or severity of adverse effects can be increased when Chlorthalidone is combined with Levobunolol.Approved
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Chlorthalidone.Approved, Investigational
LevodopaChlorthalidone may increase the orthostatic hypotensive activities of Levodopa.Approved
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Chlorthalidone.Approved, Investigational
LevomilnacipranLevomilnacipran may increase the hyponatremic activities of Chlorthalidone.Approved, Investigational
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Chlorthalidone.Approved
LevosalbutamolLevosalbutamol may increase the hypokalemic activities of Chlorthalidone.Approved, Investigational
LevosimendanThe risk or severity of adverse effects can be increased when Levosimendan is combined with Chlorthalidone.Approved, Investigational
LicoriceLicorice may increase the hypokalemic activities of Chlorthalidone.Approved
LinagliptinThe therapeutic efficacy of Linagliptin can be decreased when used in combination with Chlorthalidone.Approved
LinsidomineChlorthalidone may increase the hypotensive activities of Linsidomine.Experimental
LiraglutideThe therapeutic efficacy of Liraglutide can be decreased when used in combination with Chlorthalidone.Approved
LisinoprilThe risk or severity of hypotension can be increased when Chlorthalidone is combined with Lisinopril.Approved, Investigational
LisofyllineThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Lisofylline.Investigational
LithiumChlorthalidone may decrease the excretion rate of Lithium which could result in a higher serum level.Approved
LofentanilThe risk or severity of adverse effects can be increased when Lofentanil is combined with Chlorthalidone.Illicit
LofexidineChlorthalidone may increase the hypotensive activities of Lofexidine.Approved, Investigational
LonazolacThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Lonazolac.Experimental
LornoxicamThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Lornoxicam.Approved, Investigational
LosartanChlorthalidone may increase the hypotensive activities of Losartan.Approved
LoteprednolLoteprednol may increase the hypokalemic activities of Chlorthalidone.Approved
LoxoprofenThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Loxoprofen.Approved, Investigational
LumiracoxibThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Lumiracoxib.Approved, Investigational
MacitentanChlorthalidone may increase the hypotensive activities of Macitentan.Approved
Magnesium salicylateThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Magnesium salicylate.Approved
ManidipineChlorthalidone may increase the hypotensive activities of Manidipine.Approved, Investigational
MannitolThe risk or severity of adverse effects can be increased when Chlorthalidone is combined with Mannitol.Approved, Investigational
MasoprocolThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Masoprocol.Approved, Investigational
MaxacalcitolThe risk or severity of hyperkalemia can be increased when Maxacalcitol is combined with Chlorthalidone.Approved, Investigational
MazaticolThe serum concentration of Chlorthalidone can be increased when it is combined with Mazaticol.Experimental
ME-609ME-609 may increase the hypokalemic activities of Chlorthalidone.Investigational
MebanazineMebanazine may increase the hypotensive activities of Chlorthalidone.Withdrawn
MecamylamineThe risk or severity of adverse effects can be increased when Chlorthalidone is combined with Mecamylamine.Approved, Investigational
Meclofenamic acidThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Meclofenamic acid.Approved, Vet Approved
MedrysoneMedrysone may increase the hypokalemic activities of Chlorthalidone.Approved
Mefenamic acidThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Mefenamic acid.Approved
MelengestrolMelengestrol may increase the hypokalemic activities of Chlorthalidone.Vet Approved
MeloxicamThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Meloxicam.Approved, Vet Approved
MeptazinolThe risk or severity of adverse effects can be increased when Meptazinol is combined with Chlorthalidone.Experimental
MesalazineThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Mesalazine.Approved
MetamizoleThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Metamizole.Approved, Investigational, Withdrawn
MetforminThe therapeutic efficacy of Metformin can be decreased when used in combination with Chlorthalidone.Approved
MethadoneThe risk or severity of adverse effects can be increased when Methadone is combined with Chlorthalidone.Approved
Methadyl AcetateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Chlorthalidone.Approved, Illicit
MethanthelineThe serum concentration of Chlorthalidone can be increased when it is combined with Methantheline.Approved, Investigational
MethazolamideThe risk or severity of adverse effects can be increased when Chlorthalidone is combined with Methazolamide.Approved
MethohexitalMethohexital may increase the orthostatic hypotensive activities of Chlorthalidone.Approved
MethoserpidineChlorthalidone may increase the hypotensive activities of Methoserpidine.Experimental
MethscopolamineThe serum concentration of Chlorthalidone can be increased when it is combined with Methscopolamine.Approved
MethyclothiazideThe risk or severity of adverse effects can be increased when Methyclothiazide is combined with Chlorthalidone.Approved
MethyldopaChlorthalidone may increase the hypotensive activities of Methyldopa.Approved
Methylene blueMethylene blue may increase the hypotensive activities of Chlorthalidone.Approved, Investigational
MethylphenidateMethylphenidate may decrease the antihypertensive activities of Chlorthalidone.Approved, Investigational
MethylphenobarbitalMethylphenobarbital may increase the orthostatic hypotensive activities of Chlorthalidone.Approved
MethylprednisoloneMethylprednisolone may increase the hypokalemic activities of Chlorthalidone.Approved, Vet Approved
Methylscopolamine bromideThe serum concentration of Chlorthalidone can be increased when it is combined with Methylscopolamine bromide.Approved
MetildigoxinThe risk or severity of adverse effects can be increased when Chlorthalidone is combined with Metildigoxin.Experimental
MetipranololChlorthalidone may increase the hypotensive activities of Metipranolol.Approved
MetixeneThe serum concentration of Chlorthalidone can be increased when it is combined with Metixene.Approved
MetolazoneChlorthalidone may increase the hypotensive activities of Metolazone.Approved
MetoprololMetoprolol may increase the hypotensive activities of Chlorthalidone.Approved, Investigational
MetyrosineChlorthalidone may increase the hypotensive activities of Metyrosine.Approved
MibefradilChlorthalidone may increase the hypotensive activities of Mibefradil.Investigational, Withdrawn
MiglitolThe therapeutic efficacy of Miglitol can be decreased when used in combination with Chlorthalidone.Approved
MiglustatThe therapeutic efficacy of Miglustat can be decreased when used in combination with Chlorthalidone.Approved
MilnacipranMilnacipran may increase the hyponatremic activities of Chlorthalidone.Approved, Investigational
MinaprineMinaprine may increase the hypotensive activities of Chlorthalidone.Approved
MinoxidilMinoxidil may increase the hypotensive activities of Chlorthalidone.Approved, Investigational
MirodenafilMirodenafil may increase the antihypertensive activities of Chlorthalidone.Investigational
MitiglinideThe therapeutic efficacy of Mitiglinide can be decreased when used in combination with Chlorthalidone.Approved, Investigational
MizoribineThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Mizoribine.Investigational
MoclobemideMoclobemide may increase the hypotensive activities of Chlorthalidone.Approved, Investigational
MoexiprilThe risk or severity of hypotension can be increased when Chlorthalidone is combined with Moexipril.Approved
MofebutazoneThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Mofebutazone.Experimental
MolsidomineMolsidomine may increase the hypotensive activities of Chlorthalidone.Approved, Investigational
MometasoneMometasone may increase the hypokalemic activities of Chlorthalidone.Approved, Vet Approved
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Chlorthalidone.Approved, Investigational
MoxonidineMoxonidine may increase the hypotensive activities of Chlorthalidone.Approved, Investigational
MuzolimineChlorthalidone may increase the hypotensive activities of Muzolimine.Experimental
Mycophenolate mofetilThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Mycophenolate mofetil.Approved, Investigational
Mycophenolic acidThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Mycophenolic acid.Approved
NabiloneThe risk or severity of adverse effects can be increased when Nabilone is combined with Chlorthalidone.Approved, Investigational
NabumetoneThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Nabumetone.Approved
NadololChlorthalidone may increase the hypotensive activities of Nadolol.Approved
NafamostatThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Nafamostat.Approved, Investigational
NaftifineThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Naftifine.Approved
NaftopidilChlorthalidone may increase the hypotensive activities of Naftopidil.Investigational
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Chlorthalidone.Approved
NaproxenThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Naproxen.Approved, Vet Approved
NateglinideThe therapeutic efficacy of Nateglinide can be decreased when used in combination with Chlorthalidone.Approved, Investigational
NCX 1022NCX 1022 may increase the hypokalemic activities of Chlorthalidone.Investigational
NebivololChlorthalidone may increase the hypotensive activities of Nebivolol.Approved, Investigational
NefazodoneNefazodone may increase the hyponatremic activities of Chlorthalidone.Approved, Withdrawn
NepafenacThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Nepafenac.Approved, Investigational
NesiritideThe risk or severity of adverse effects can be increased when Chlorthalidone is combined with Nesiritide.Approved, Investigational
NialamideNialamide may increase the hypotensive activities of Chlorthalidone.Withdrawn
NicardipineChlorthalidone may increase the hypotensive activities of Nicardipine.Approved, Investigational
NicomorphineThe risk or severity of adverse effects can be increased when Nicomorphine is combined with Chlorthalidone.Experimental
NicorandilNicorandil may increase the hypotensive activities of Chlorthalidone.Approved, Investigational
NifedipineThe risk or severity of adverse effects can be increased when Chlorthalidone is combined with Nifedipine.Approved
NifenazoneThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Nifenazone.Experimental
Niflumic AcidThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Niflumic Acid.Approved
NiguldipineChlorthalidone may increase the hypotensive activities of Niguldipine.Experimental
NilvadipineChlorthalidone may increase the hypotensive activities of Nilvadipine.Approved, Investigational
NimesulideThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Nimesulide.Approved, Investigational, Withdrawn
NimodipineChlorthalidone may increase the hypotensive activities of Nimodipine.Approved, Investigational
NisoldipineChlorthalidone may increase the hypotensive activities of Nisoldipine.Approved
NitrendipineChlorthalidone may increase the hypotensive activities of Nitrendipine.Approved, Investigational
Nitric OxideThe risk or severity of adverse effects can be increased when Nitric Oxide is combined with Chlorthalidone.Approved
NitroaspirinThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Nitroaspirin.Investigational
NitroglycerinThe risk or severity of adverse effects can be increased when Chlorthalidone is combined with Nitroglycerin.Approved, Investigational
NitroprussideNitroprusside may increase the hypotensive activities of Chlorthalidone.Approved, Investigational
Nitrous acidThe risk or severity of adverse effects can be increased when Nitrous acid is combined with Chlorthalidone.Approved, Investigational
NorepinephrineNorepinephrine may increase the hypokalemic activities of Chlorthalidone.Approved
NormethadoneThe risk or severity of adverse effects can be increased when Normethadone is combined with Chlorthalidone.Approved, Illicit
ObinutuzumabChlorthalidone may increase the hypotensive activities of Obinutuzumab.Approved, Investigational
OctamoxinOctamoxin may increase the hypotensive activities of Chlorthalidone.Withdrawn
OleandrinThe risk or severity of adverse effects can be increased when Chlorthalidone is combined with Oleandrin.Experimental, Investigational
Oleoyl-estroneOleoyl-estrone may increase the hypokalemic activities of Chlorthalidone.Investigational
OlmesartanOlmesartan may increase the hypotensive activities of Chlorthalidone.Approved, Investigational
OlodaterolOlodaterol may increase the hypokalemic activities of Chlorthalidone.Approved
OlopatadineThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Olopatadine.Approved
OlsalazineThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Olsalazine.Approved
OmapatrilatThe risk or severity of hypotension can be increased when Chlorthalidone is combined with Omapatrilat.Investigational
OpiumThe risk or severity of adverse effects can be increased when Opium is combined with Chlorthalidone.Approved, Illicit
OrciprenalineOrciprenaline may increase the hypokalemic activities of Chlorthalidone.Approved
OrgoteinThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Orgotein.Vet Approved
OrphenadrineThe serum concentration of Chlorthalidone can be increased when it is combined with Orphenadrine.Approved
OtiloniumThe serum concentration of Chlorthalidone can be increased when it is combined with Otilonium.Experimental, Investigational
OuabainThe risk or severity of adverse effects can be increased when Chlorthalidone is combined with Ouabain.Approved
OxaprozinThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Oxaprozin.Approved
OxcarbazepineThe risk or severity of hyponatremia can be increased when Chlorthalidone is combined with Oxcarbazepine.Approved
OxitropiumThe serum concentration of Chlorthalidone can be increased when it is combined with Oxitropium.Investigational
OxprenololChlorthalidone may increase the hypotensive activities of Oxprenolol.Approved
OxybutyninThe serum concentration of Chlorthalidone can be increased when it is combined with Oxybutynin.Approved, Investigational
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Chlorthalidone.Approved, Illicit, Investigational
OxymorphoneThe risk or severity of adverse effects can be increased when Oxymorphone is combined with Chlorthalidone.Approved, Investigational, Vet Approved
OxyphenbutazoneThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Oxyphenbutazone.Approved, Withdrawn
OxyphenoniumThe serum concentration of Chlorthalidone can be increased when it is combined with Oxyphenonium.Approved
PaclitaxelThe risk or severity of adverse effects can be increased when Paclitaxel is combined with Chlorthalidone.Approved, Vet Approved
PancuroniumThe serum concentration of Chlorthalidone can be increased when it is combined with Pancuronium.Approved
PapaverineThe risk or severity of adverse effects can be increased when Chlorthalidone is combined with Papaverine.Approved, Investigational
ParamethasoneParamethasone may increase the hypokalemic activities of Chlorthalidone.Approved
ParecoxibThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Parecoxib.Approved
PargylinePargyline may increase the hypotensive activities of Chlorthalidone.Approved
ParicalcitolThe risk or severity of hyperkalemia can be increased when Paricalcitol is combined with Chlorthalidone.Approved, Investigational
ParoxetineParoxetine may increase the hyponatremic activities of Chlorthalidone.Approved, Investigational
ParthenolideThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Parthenolide.Approved, Investigational
PenbutololChlorthalidone may increase the hypotensive activities of Penbutolol.Approved, Investigational
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Chlorthalidone.Approved, Vet Approved
PentobarbitalPentobarbital may increase the orthostatic hypotensive activities of Chlorthalidone.Approved, Investigational, Vet Approved
PentoliniumThe serum concentration of Chlorthalidone can be increased when it is combined with Pentolinium.Approved
PentoxifyllinePentoxifylline may increase the hypotensive activities of Chlorthalidone.Approved, Investigational
PerindoprilThe risk or severity of hypotension can be increased when Chlorthalidone is combined with Perindopril.Approved
PeruvosideThe risk or severity of adverse effects can be increased when Chlorthalidone is combined with Peruvoside.Experimental
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Chlorthalidone.Approved
PhenazocineThe risk or severity of adverse effects can be increased when Phenazocine is combined with Chlorthalidone.Experimental
PhenelzinePhenelzine may increase the hypotensive activities of Chlorthalidone.Approved
PhenforminThe therapeutic efficacy of Phenformin can be decreased when used in combination with Chlorthalidone.Approved, Investigational, Withdrawn
PhenglutarimideThe serum concentration of Chlorthalidone can be increased when it is combined with Phenglutarimide.Experimental
PheniprazinePheniprazine may increase the hypotensive activities of Chlorthalidone.Withdrawn
PhenobarbitalPhenobarbital may increase the orthostatic hypotensive activities of Chlorthalidone.Approved, Investigational
PhenoperidineThe risk or severity of adverse effects can be increased when Phenoperidine is combined with Chlorthalidone.Experimental
PhenoxybenzamineChlorthalidone may increase the hypotensive activities of Phenoxybenzamine.Approved
PhenoxypropazinePhenoxypropazine may increase the hypotensive activities of Chlorthalidone.Withdrawn
PhentolamineChlorthalidone may increase the hypotensive activities of Phentolamine.Approved
PhenylbutazoneThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Phenylbutazone.Approved, Vet Approved
PhenylpropanolaminePhenylpropanolamine may increase the hypokalemic activities of Chlorthalidone.Approved, Vet Approved, Withdrawn
PimecrolimusThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Pimecrolimus.Approved, Investigational
PinacidilPinacidil may increase the hypotensive activities of Chlorthalidone.Approved
PindololChlorthalidone may increase the hypotensive activities of Pindolol.Approved, Investigational
PioglitazoneThe therapeutic efficacy of Pioglitazone can be decreased when used in combination with Chlorthalidone.Approved, Investigational
PipamperoneThe risk or severity of adverse effects can be increased when Pipamperone is combined with Chlorthalidone.Approved, Investigational
PipecuroniumThe serum concentration of Chlorthalidone can be increased when it is combined with Pipecuronium.Approved
PirbuterolPirbuterol may increase the hypokalemic activities of Chlorthalidone.Approved
PirenzepineThe serum concentration of Chlorthalidone can be increased when it is combined with Pirenzepine.Approved
PirfenidoneThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Pirfenidone.Approved, Investigational
PiritramideThe risk or severity of adverse effects can be increased when Piritramide is combined with Chlorthalidone.Approved, Investigational
PirlindolePirlindole may increase the hypotensive activities of Chlorthalidone.Approved
PiroxicamThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Piroxicam.Approved, Investigational
PirprofenThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Pirprofen.Experimental
PivhydrazinePivhydrazine may increase the hypotensive activities of Chlorthalidone.Withdrawn
Platelet Activating FactorChlorthalidone may increase the hypotensive activities of Platelet Activating Factor.Experimental
PolythiazideChlorthalidone may increase the hypotensive activities of Polythiazide.Approved
PramipexoleThe risk or severity of adverse effects can be increased when Pramipexole is combined with Chlorthalidone.Approved, Investigational
PramlintideThe therapeutic efficacy of Pramlintide can be decreased when used in combination with Chlorthalidone.Approved, Investigational
PranoprofenThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Pranoprofen.Experimental, Investigational
PrasteronePrasterone may increase the hypokalemic activities of Chlorthalidone.Approved, Investigational, Nutraceutical
Prasterone sulfatePrasterone sulfate may increase the hypokalemic activities of Chlorthalidone.Investigational
PrazosinPrazosin may increase the hypotensive activities of Chlorthalidone.Approved
PrednicarbatePrednicarbate may increase the hypokalemic activities of Chlorthalidone.Approved, Investigational
PrednisolonePrednisolone may increase the hypokalemic activities of Chlorthalidone.Approved, Vet Approved
PrednisonePrednisone may increase the hypokalemic activities of Chlorthalidone.Approved, Vet Approved
PregnenolonePregnenolone may increase the hypokalemic activities of Chlorthalidone.Approved, Experimental, Investigational
PrimidonePrimidone may increase the orthostatic hypotensive activities of Chlorthalidone.Approved, Vet Approved
ProcarbazineProcarbazine may increase the hypotensive activities of Chlorthalidone.Approved, Investigational
ProcaterolProcaterol may increase the hypokalemic activities of Chlorthalidone.Approved, Investigational
ProcyclidineThe serum concentration of Chlorthalidone can be increased when it is combined with Procyclidine.Approved
ProglumetacinThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Proglumetacin.Experimental
PropacetamolThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Propacetamol.Approved, Investigational
PropanthelineThe serum concentration of Chlorthalidone can be increased when it is combined with Propantheline.Approved
PropiverineThe serum concentration of Chlorthalidone can be increased when it is combined with Propiverine.Approved, Investigational
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Chlorthalidone.Approved, Investigational, Vet Approved
PropranololChlorthalidone may increase the hypotensive activities of Propranolol.Approved, Investigational
PropyphenazoneThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Propyphenazone.Experimental
ProquazoneThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Proquazone.Experimental
ProscillaridinThe risk or severity of adverse effects can be increased when Chlorthalidone is combined with Proscillaridin.Experimental
ProtokylolProtokylol may increase the hypokalemic activities of Chlorthalidone.Approved, Vet Approved
PTC299The therapeutic efficacy of Chlorthalidone can be decreased when used in combination with PTC299.Investigational
QuetiapineThe risk or severity of adverse effects can be increased when Chlorthalidone is combined with Quetiapine.Approved
QuinaprilThe risk or severity of hypotension can be increased when Chlorthalidone is combined with Quinapril.Approved, Investigational
QuinidineThe serum concentration of Chlorthalidone can be increased when it is combined with Quinidine.Approved, Investigational
QuinineQuinine may increase the hypotensive activities of Chlorthalidone.Approved
RacepinephrineRacepinephrine may increase the hypokalemic activities of Chlorthalidone.Approved
RamiprilThe risk or severity of hypotension can be increased when Chlorthalidone is combined with Ramipril.Approved
RasagilineRasagiline may increase the hypotensive activities of Chlorthalidone.Approved
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Chlorthalidone.Approved
RemikirenRemikiren may increase the hypotensive activities of Chlorthalidone.Approved
RepaglinideThe therapeutic efficacy of Repaglinide can be decreased when used in combination with Chlorthalidone.Approved, Investigational
RescinnamineThe risk or severity of hypotension can be increased when Chlorthalidone is combined with Rescinnamine.Approved
ReserpineReserpine may increase the hypotensive activities of Chlorthalidone.Approved, Investigational
ResveratrolThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Resveratrol.Approved, Experimental, Investigational
RilmenidineRilmenidine may increase the hypotensive activities of Chlorthalidone.Approved, Investigational
RimexoloneRimexolone may increase the hypokalemic activities of Chlorthalidone.Approved
RiociguatChlorthalidone may increase the hypotensive activities of Riociguat.Approved
RisperidoneChlorthalidone may increase the hypotensive activities of Risperidone.Approved, Investigational
RitodrineRitodrine may increase the hypokalemic activities of Chlorthalidone.Approved, Investigational
RituximabChlorthalidone may increase the hypotensive activities of Rituximab.Approved
RofecoxibThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Rofecoxib.Approved, Investigational, Withdrawn
RopiniroleThe risk or severity of adverse effects can be increased when Ropinirole is combined with Chlorthalidone.Approved, Investigational
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Chlorthalidone.Approved
RosiglitazoneThe therapeutic efficacy of Rosiglitazone can be decreased when used in combination with Chlorthalidone.Approved, Investigational
RotigotineThe risk or severity of adverse effects can be increased when Rotigotine is combined with Chlorthalidone.Approved
SacubitrilThe risk or severity of adverse effects can be increased when Sacubitril is combined with Chlorthalidone.Approved
SafrazineSafrazine may increase the hypotensive activities of Chlorthalidone.Withdrawn
SalbutamolSalbutamol may increase the hypokalemic activities of Chlorthalidone.Approved, Vet Approved
SalicylamideThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Salicylamide.Approved
Salicylic acidThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Salicylic acid.Approved, Investigational, Vet Approved
SalmeterolSalmeterol may increase the hypokalemic activities of Chlorthalidone.Approved
SalsalateThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Salsalate.Approved
SaprisartanChlorthalidone may increase the hypotensive activities of Saprisartan.Experimental
SaxagliptinThe therapeutic efficacy of Saxagliptin can be decreased when used in combination with Chlorthalidone.Approved
ScopolamineThe serum concentration of Chlorthalidone can be increased when it is combined with Scopolamine.Approved, Investigational
SecobarbitalSecobarbital may increase the orthostatic hypotensive activities of Chlorthalidone.Approved, Vet Approved
SelegilineSelegiline may increase the hypotensive activities of Chlorthalidone.Approved, Investigational, Vet Approved
SelexipagChlorthalidone may increase the hypotensive activities of Selexipag.Approved
SemapimodThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Semapimod.Investigational
SeocalcitolThe risk or severity of hyperkalemia can be increased when Seocalcitol is combined with Chlorthalidone.Experimental, Investigational
SeratrodastThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Seratrodast.Approved
SerrapeptaseThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Serrapeptase.Investigational
SertralineSertraline may increase the hyponatremic activities of Chlorthalidone.Approved
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Chlorthalidone.Approved, Vet Approved
SildenafilSildenafil may increase the antihypertensive activities of Chlorthalidone.Approved, Investigational
SitagliptinThe therapeutic efficacy of Sitagliptin can be decreased when used in combination with Chlorthalidone.Approved, Investigational
SitaxentanChlorthalidone may increase the hypotensive activities of Sitaxentan.Approved, Investigational, Withdrawn
Sodium phosphateChlorthalidone may increase the nephrotoxic activities of Sodium phosphate.Approved
SolifenacinThe serum concentration of Chlorthalidone can be increased when it is combined with Solifenacin.Approved
SotagliflozinThe therapeutic efficacy of Sotagliflozin can be decreased when used in combination with Chlorthalidone.Investigational
SotalolThe risk or severity of adverse effects can be increased when Chlorthalidone is combined with Sotalol.Approved
SpiraprilThe risk or severity of hypotension can be increased when Chlorthalidone is combined with Spirapril.Approved
SpironolactoneThe risk or severity of adverse effects can be increased when Chlorthalidone is combined with Spironolactone.Approved
SRT501The therapeutic efficacy of Chlorthalidone can be decreased when used in combination with SRT501.Investigational
StreptokinaseThe risk or severity of adverse effects can be increased when Streptokinase is combined with Chlorthalidone.Approved, Investigational
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Chlorthalidone.Approved, Investigational
SulfasalazineThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Sulfasalazine.Approved
SulodexideThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Chlorthalidone.Approved, Investigational
SulpirideThe risk or severity of adverse effects can be increased when Chlorthalidone is combined with Sulpiride.Approved, Investigational
SuprofenThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Suprofen.Approved, Withdrawn
SuxibuzoneThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Suxibuzone.Experimental
TacalcitolThe risk or severity of hyperkalemia can be increased when Tacalcitol is combined with Chlorthalidone.Experimental, Investigational
TadalafilTadalafil may increase the antihypertensive activities of Chlorthalidone.Approved, Investigational
TalinololChlorthalidone may increase the hypotensive activities of Talinolol.Investigational
TamsulosinThe risk or severity of adverse effects can be increased when Tamsulosin is combined with Chlorthalidone.Approved, Investigational
TapentadolThe risk or severity of adverse effects can be increased when Tapentadol is combined with Chlorthalidone.Approved
TarenflurbilThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Tarenflurbil.Investigational
TelmisartanChlorthalidone may increase the hypotensive activities of Telmisartan.Approved, Investigational
TemocaprilThe risk or severity of hypotension can be increased when Chlorthalidone is combined with Temocapril.Experimental, Investigational
TenidapThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Tenidap.Experimental
TenoxicamThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Tenoxicam.Approved
TepoxalinThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Tepoxalin.Vet Approved
TerazosinThe risk or severity of adverse effects can be increased when Chlorthalidone is combined with Terazosin.Approved
TerbutalineTerbutaline may increase the hypokalemic activities of Chlorthalidone.Approved
TeriflunomideThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Teriflunomide.Approved
TerlipressinChlorthalidone may increase the hypotensive activities of Terlipressin.Approved, Investigational
TetrahydropalmatineChlorthalidone may increase the hypotensive activities of Tetrahydropalmatine.Investigational
ThalidomideThe risk or severity of adverse effects can be increased when Thalidomide is combined with Chlorthalidone.Approved, Investigational, Withdrawn
TheodrenalineChlorthalidone may increase the hypotensive activities of Theodrenaline.Investigational
ThiamylalThiamylal may increase the orthostatic hypotensive activities of Chlorthalidone.Approved, Vet Approved
ThiopentalThiopental may increase the orthostatic hypotensive activities of Chlorthalidone.Approved, Vet Approved
ThioridazineThe risk or severity of adverse effects can be increased when Thioridazine is combined with Chlorthalidone.Approved, Withdrawn
Tiaprofenic acidThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Tiaprofenic acid.Approved
TiboloneChlorthalidone may increase the hypotensive activities of Tibolone.Approved, Investigational
TicrynafenChlorthalidone may increase the hypotensive activities of Ticrynafen.Withdrawn
TilidineThe risk or severity of adverse effects can be increased when Tilidine is combined with Chlorthalidone.Experimental
TimololChlorthalidone may increase the hypotensive activities of Timolol.Approved
TinoridineThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Tinoridine.Investigational
TiotropiumThe serum concentration of Chlorthalidone can be increased when it is combined with Tiotropium.Approved
TixocortolTixocortol may increase the hypokalemic activities of Chlorthalidone.Approved, Withdrawn
TizanidineThe risk or severity of adverse effects can be increased when Chlorthalidone is combined with Tizanidine.Approved, Investigational
TolazamideThe therapeutic efficacy of Tolazamide can be decreased when used in combination with Chlorthalidone.Approved, Investigational
TolazolineChlorthalidone may increase the hypotensive activities of Tolazoline.Approved, Vet Approved
TolbutamideThe therapeutic efficacy of Tolbutamide can be decreased when used in combination with Chlorthalidone.Approved, Investigational
TolcaponeThe risk or severity of adverse effects can be increased when Tolcapone is combined with Chlorthalidone.Approved, Withdrawn
Tolfenamic AcidThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Tolfenamic Acid.Approved, Investigational
TolmetinThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Tolmetin.Approved
TolonidineChlorthalidone may increase the hypotensive activities of Tolonidine.Experimental
ToloxatoneToloxatone may increase the hypotensive activities of Chlorthalidone.Approved
TolterodineThe serum concentration of Chlorthalidone can be increased when it is combined with Tolterodine.Approved, Investigational
TorasemideTorasemide may increase the hypotensive activities of Chlorthalidone.Approved
ToremifeneChlorthalidone may increase the hypercalcemic activities of Toremifene.Approved, Investigational
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Chlorthalidone.Approved, Investigational
TrandolaprilThe risk or severity of hypotension can be increased when Chlorthalidone is combined with Trandolapril.Approved
TranilastThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Tranilast.Approved, Investigational
TranylcypromineTranylcypromine may increase the hypotensive activities of Chlorthalidone.Approved, Investigational
TravoprostTravoprost may increase the hypotensive activities of Chlorthalidone.Approved
TreprostinilChlorthalidone may increase the hypotensive activities of Treprostinil.Approved, Investigational
TretinoinThe risk or severity of adverse effects can be increased when Tretinoin is combined with Chlorthalidone.Approved, Investigational, Nutraceutical
TriamcinoloneTriamcinolone may increase the hypokalemic activities of Chlorthalidone.Approved, Vet Approved
TriamtereneThe risk or severity of adverse effects can be increased when Chlorthalidone is combined with Triamterene.Approved
TribenosideThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Tribenoside.Experimental
TrichlormethiazideChlorthalidone may increase the hypotensive activities of Trichlormethiazide.Approved, Vet Approved
TrihexyphenidylThe serum concentration of Chlorthalidone can be increased when it is combined with Trihexyphenidyl.Approved
TrimazosinTrimazosin may increase the hypotensive activities of Chlorthalidone.Experimental
TrimethaphanThe serum concentration of Chlorthalidone can be increased when it is combined with Trimethaphan.Approved, Investigational
TriptolideThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Triptolide.Investigational
TroglitazoneThe therapeutic efficacy of Troglitazone can be decreased when used in combination with Chlorthalidone.Investigational, Withdrawn
TropatepineThe serum concentration of Chlorthalidone can be increased when it is combined with Tropatepine.Experimental
TropicamideThe serum concentration of Chlorthalidone can be increased when it is combined with Tropicamide.Approved, Investigational
TrospiumThe serum concentration of Chlorthalidone can be increased when it is combined with Trospium.Approved
TubocurarineThe serum concentration of Chlorthalidone can be increased when it is combined with Tubocurarine.Approved
UdenafilUdenafil may increase the antihypertensive activities of Chlorthalidone.Approved, Investigational
UlobetasolUlobetasol may increase the hypokalemic activities of Chlorthalidone.Approved
UmeclidiniumThe serum concentration of Chlorthalidone can be increased when it is combined with Umeclidinium.Approved
UnoprostoneChlorthalidone may increase the hypotensive activities of Unoprostone.Approved, Investigational
UrapidilUrapidil may increase the hypotensive activities of Chlorthalidone.Investigational
ValdecoxibThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Valdecoxib.Approved, Investigational, Withdrawn
ValsartanValsartan may increase the hypotensive activities of Chlorthalidone.Approved, Investigational
VardenafilVardenafil may increase the antihypertensive activities of Chlorthalidone.Approved
VecuroniumThe serum concentration of Chlorthalidone can be increased when it is combined with Vecuronium.Approved
VenlafaxineVenlafaxine may increase the hyponatremic activities of Chlorthalidone.Approved
VerapamilThe risk or severity of adverse effects can be increased when Chlorthalidone is combined with Verapamil.Approved
VilanterolVilanterol may increase the hypokalemic activities of Chlorthalidone.Approved
VildagliptinThe therapeutic efficacy of Vildagliptin can be decreased when used in combination with Chlorthalidone.Approved, Investigational
VincamineChlorthalidone may increase the hypotensive activities of Vincamine.Experimental
VinpocetineChlorthalidone may increase the hypotensive activities of Vinpocetine.Investigational
Vitamin DThe risk or severity of hyperkalemia can be increased when Vitamin D is combined with Chlorthalidone.Approved, Nutraceutical, Vet Approved
VogliboseThe therapeutic efficacy of Voglibose can be decreased when used in combination with Chlorthalidone.Approved, Investigational
XipamideChlorthalidone may increase the hypotensive activities of Xipamide.Experimental
XylometazolineChlorthalidone may increase the hypotensive activities of Xylometazoline.Approved, Investigational
YohimbineYohimbine may decrease the antihypertensive activities of Chlorthalidone.Approved, Investigational, Vet Approved
ZaltoprofenThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Zaltoprofen.Approved, Investigational
ZileutonThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Zileuton.Approved, Investigational, Withdrawn
ZimelidineZimelidine may increase the hyponatremic activities of Chlorthalidone.Withdrawn
ZofenoprilThe risk or severity of hypotension can be increased when Chlorthalidone is combined with Zofenopril.Experimental
ZomepiracThe therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Zomepirac.Withdrawn
Food Interactions
  • Take with food (increases availability).

References

Synthesis Reference

Graf, W., Schmid, E. and Stoll, W.G.; US Patent 3,055,904; September 25,1962; assigned to Geigy Chemical Corporation.

General References
Not Available
External Links
Human Metabolome Database
HMDB0014455
KEGG Drug
D00272
PubChem Compound
2732
PubChem Substance
46505541
ChemSpider
2631
BindingDB
25900
ChEBI
3654
ChEMBL
CHEMBL1055
Therapeutic Targets Database
DAP000521
PharmGKB
PA448970
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
Wikipedia
Chlorthalidone
ATC Codes
C03BA04 — ChlortalidoneC03BB04 — Chlortalidone and potassiumC03EA06 — Chlortalidone and potassium-sparing agentsG01AE10 — Combinations of sulfonamides
AHFS Codes
  • 40:28.24 — Thiazide-like Diuretics

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedNot AvailableHigh Blood Pressure (Hypertension)1
1CompletedBasic ScienceHigh Blood Pressure (Hypertension)1
1CompletedBasic ScienceHypertension(HTN)1
1CompletedTreatmentHigh Blood Pressure (Hypertension)1
2CompletedTreatmentCardiovascular Disease (CVD) / Heart Diseases / High Blood Pressure (Hypertension) / Vascular Diseases2
2Not Yet RecruitingTreatmentDiabetes, Diabetes Mellitus Type 1 / Hypercalciuria1
2RecruitingTreatmentHigh Blood Pressure (Hypertension)1
2RecruitingTreatmentHigh Blood Pressure (Hypertension) / Renal Insufficiency,Chronic1
3CompletedNot AvailableCardiovascular Disease (CVD) / Death, Sudden,Cardiac / Heart Arrest / Heart Diseases / High Blood Pressure (Hypertension)1
3CompletedPreventionAtherosclerosis / Cardiovascular Disease (CVD) / Coronary Heart Disease (CHD) / Diabetes Mellitus (DM) / High Blood Cholesterol Level / High Blood Pressure (Hypertension) / Type 2 Diabetes Mellitus1
3CompletedPreventionCardiovascular Disease (CVD) / Cerebrovascular Disorders / Heart Diseases / High Blood Pressure (Hypertension)1
3CompletedPreventionCardiovascular Disease (CVD) / Coronary Heart Disease (CHD) / Diabetes Mellitus (DM) / Heart Diseases / Heart Failure, Unspecified / High Blood Cholesterol Level / High Blood Pressure (Hypertension) / Myocardial Infarction (MI) / Myocardial Ischemia1
3CompletedTreatmentCardiovascular Disease (CVD) / Heart Diseases / High Blood Pressure (Hypertension)1
3CompletedTreatmentCardiovascular Disease (CVD) / Heart Diseases / High Blood Pressure (Hypertension) / Vascular Diseases1
3CompletedTreatmentHigh Blood Pressure (Hypertension)4
3CompletedTreatmentHigh Blood Pressure (Hypertension) / Obstructive Sleep Apnea (OSA)1
3CompletedTreatmentHigh Blood Pressure (Hypertension) / Transplantation, Kidney1
3CompletedTreatmentHypertension,Essential5
3CompletedTreatmentSafety1
3RecruitingTreatmentHigh Blood Pressure (Hypertension)1
3WithdrawnTreatmentEssential Arterial Hypertension2
4Active Not RecruitingTreatmentCardio-Renal Syndrome / Renal Insufficiency,Chronic1
4CompletedPreventionHigh Blood Pressure (Hypertension)1
4CompletedTreatmentChronic Kidney Disease (CKD) / Poorly-Controlled Hypertension1
4CompletedTreatmentHigh Blood Pressure (Hypertension)1
4RecruitingNot AvailableHigh Blood Pressure (Hypertension) / Hypertension,Essential / Resistant Hypertension1
4RecruitingTreatmentHigh Blood Pressure (Hypertension)2
4RecruitingTreatmentHypertension,Essential1
4TerminatedTreatmentDiabetes Mellitus (DM) / High Blood Pressure (Hypertension) / Stage 2 Hypertension1
4WithdrawnTreatmentHigh Blood Pressure (Hypertension)2
4WithdrawnTreatmentResistant Hypertension in Kidney Transplant Patients1
Not AvailableCompletedNot AvailableCardiovascular Disease (CVD) / Coronary Heart Disease (CHD) / Heart Diseases / High Blood Pressure (Hypertension) / Myocardial Infarction (MI)1
Not AvailableCompletedNot AvailableHigh Blood Pressure (Hypertension)1
Not AvailableCompletedDiagnosticHigh Blood Pressure (Hypertension)1
Not AvailableRecruitingPreventionHigh Blood Pressure (Hypertension)1
Not AvailableRecruitingPreventionRenal Stones1
Not AvailableRecruitingTreatmentHigh Blood Pressure (Hypertension)1

Pharmacoeconomics

Manufacturers
  • Abbott laboratories pharmaceutical products div
  • Ascot hosp pharmaceuticals inc div travenol laboratories inc
  • Clonmel healthcare ltd
  • Ivax pharmaceuticals inc
  • Kv pharmaceutical co
  • Mutual pharmaceutical co inc
  • Mylan pharmaceuticals inc
  • Pioneer pharmaceuticals inc
  • Pliva inc
  • Purepac pharmaceutical co
  • Sandoz inc
  • Superpharm corp
  • Teva pharmaceuticals usa inc
  • Usl pharma inc
  • Vangard laboratories inc div midway medical co
  • Warner chilcott div warner lambert co
  • Watson laboratories inc
  • Sanofi aventis us llc
  • Monarch pharmaceuticals inc
Packagers
  • Advanced Pharmaceutical Services Inc.
  • Amerisource Health Services Corp.
  • Apothecon
  • A-S Medication Solutions LLC
  • AstraZeneca Inc.
  • Bryant Ranch Prepack
  • Comprehensive Consultant Services Inc.
  • Dispensing Solutions
  • Diversified Healthcare Services Inc.
  • H and H Laboratories
  • Hl Moore Drug Exchange
  • IPR Pharmaceuticals Inc.
  • Ivax Pharmaceuticals
  • Kaiser Foundation Hospital
  • King Pharmaceuticals Inc.
  • Lake Erie Medical and Surgical Supply
  • Major Pharmaceuticals
  • Medvantx Inc.
  • Merckle GmbH
  • Monarch Pharmacy
  • Murfreesboro Pharmaceutical Nursing Supply
  • Mutual Pharmaceutical Co.
  • Mylan
  • Nucare Pharmaceuticals Inc.
  • Palmetto Pharmaceuticals Inc.
  • PD-Rx Pharmaceuticals Inc.
  • Pharmaceutical Utilization Management Program VA Inc.
  • Physicians Total Care Inc.
  • Pliva Inc.
  • Preferred Pharmaceuticals Inc.
  • Prepak Systems Inc.
  • Qualitest
  • Rebel Distributors Corp.
  • Remedy Repack
  • Sandhills Packaging Inc.
  • Southwood Pharmaceuticals
  • Stat Scripts LLC
  • UDL Laboratories
  • Watson Pharmaceuticals
Dosage forms
FormRouteStrength
TabletOral
TabletOral25 mg/1
TabletOral50 mg/1
TabletOral50 mg
TabletOral15 mg/1
TabletOral100 mg
Prices
Unit descriptionCostUnit
Tenoretic 100 100-25 mg tablet2.91USD tablet
Tenoretic 100 tablet2.91USD tablet
Tenoretic 50 50-25 mg tablet2.18USD tablet
Tenoretic 50 tablet2.07USD tablet
Thalitone 15 mg tablet1.55USD tablet
Chlorthalidone 100 mg tablet1.07USD tablet
Chlorthalidone 50 mg tablet0.46USD tablet
Chlorthalidone 25 mg tablet0.28USD tablet
Apo-Chlorthalidone 50 mg Tablet0.13USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US9169238No2010-02-252030-02-25Us
US7572920No2005-01-072025-01-07Us
US9066936No2008-03-262028-03-26Us
US7157584No2005-05-222025-05-22Us

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)239 °CPhysProp
water solubility120 mg/L (at 20 °C)MERCK INDEX (1996)
logP0.85BERTHOD,A ET AL. (1999)
Predicted Properties
PropertyValueSource
Water Solubility0.0528 mg/mLALOGPS
logP1.27ALOGPS
logP1.6ChemAxon
logS-3.8ALOGPS
pKa (Strongest Acidic)8.58ChemAxon
pKa (Strongest Basic)-2.6ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area109.49 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity81.3 m3·mol-1ChemAxon
Polarizability31.23 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+1.0
Blood Brain Barrier+0.5447
Caco-2 permeable-0.6272
P-glycoprotein substrateNon-substrate0.767
P-glycoprotein inhibitor INon-inhibitor0.9603
P-glycoprotein inhibitor IINon-inhibitor0.9573
Renal organic cation transporterNon-inhibitor0.891
CYP450 2C9 substrateNon-substrate0.6403
CYP450 2D6 substrateNon-substrate0.822
CYP450 3A4 substrateNon-substrate0.6369
CYP450 1A2 substrateNon-inhibitor0.9046
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorNon-inhibitor0.9231
CYP450 2C19 inhibitorNon-inhibitor0.9025
CYP450 3A4 inhibitorNon-inhibitor0.9299
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8193
Ames testNon AMES toxic0.7277
CarcinogenicityNon-carcinogens0.5752
BiodegradationNot ready biodegradable1.0
Rat acute toxicity1.8623 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9968
hERG inhibition (predictor II)Non-inhibitor0.8914
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-qTof , PositiveLC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-qTof , PositiveLC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-QFT , negativeLC-MS/MSsplash10-000i-0609000000-faf1d2e7aeaeb67be716
LC-MS/MS Spectrum - LC-ESI-QFT , negativeLC-MS/MSsplash10-000b-1910000000-e0b8fe4609e6388b1ffd
LC-MS/MS Spectrum - LC-ESI-QFT , negativeLC-MS/MSsplash10-002b-4910000000-73abcbf2a1d59168b6bf
LC-MS/MS Spectrum - LC-ESI-QFT , negativeLC-MS/MSsplash10-002b-7900000000-f7d1994811fe2a4e97a7
LC-MS/MS Spectrum - LC-ESI-QFT , negativeLC-MS/MSsplash10-004j-9600000000-fa803d15f1d75531f680
LC-MS/MS Spectrum - LC-ESI-QFT , negativeLC-MS/MSsplash10-01ta-9300000000-f8f2617e8f0094998274
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-00di-0009000000-0395bc83917f9fc4af05
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-00di-0029000000-bbee59ce6cba3ba80a24
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-0006-0192000000-8f7aa98268ee9e344849
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-0006-1490000000-7e99919cc132fee88dbf
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-0udr-1950000000-4195d981453db67a37b0
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-0udi-1910000000-27cef04d1420bbc9441e
MS/MS Spectrum - , positiveLC-MS/MSsplash10-00di-0269000000-ea7da059eeece096f30e
MS/MS Spectrum - , positiveLC-MS/MSsplash10-0006-2982000000-a0107386ee7e2a9cf40e

Taxonomy

Description
This compound belongs to the class of organic compounds known as isoindolones. These are aromatic polycyclic compounds that an isoindole bearing a ketone.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Isoindoles and derivatives
Sub Class
Isoindolines
Direct Parent
Isoindolones
Alternative Parents
Benzenesulfonamides / Benzenesulfonyl compounds / Isoindoles / Chlorobenzenes / Aryl chlorides / Organosulfonamides / Aminosulfonyl compounds / Lactams / Secondary carboxylic acid amides / Alkanolamines
show 6 more
Substituents
Benzenesulfonamide / Isoindolone / Isoindole / Benzenesulfonyl group / Chlorobenzene / Halobenzene / Aryl chloride / Aryl halide / Monocyclic benzene moiety / Organosulfonic acid amide
show 22 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
sulfonamide, monochlorobenzenes, isoindoles (CHEBI:3654)

Targets

Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Inhibitor
General Function
Sodium:potassium:chloride symporter activity
Specific Function
Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume.
Gene Name
SLC12A1
Uniprot ID
Q13621
Uniprot Name
Solute carrier family 12 member 1
Molecular Weight
121449.13 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
  3. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352]

Drug created on June 13, 2005 07:24 / Updated on May 26, 2018 08:44