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Identification
NameMethadyl Acetate
Accession NumberDB01433
TypeSmall Molecule
GroupsApproved, Illicit
DescriptionA narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence. [PubChem]
Structure
Thumb
Synonyms
Acetilmetadol
Acetylmethadol
Acetylmethadolum
Betamethadol
External Identifiers Not Available
Approved Prescription ProductsNot Available
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
SaltsNot Available
Categories
UNIIL59OC40KWJ
CAS number509-74-0
WeightAverage: 353.4977
Monoisotopic: 353.235479241
Chemical FormulaC23H31NO2
InChI KeyXBMIVRRWGCYBTQ-UHFFFAOYSA-N
InChI
InChI=1S/C23H31NO2/c1-6-22(26-19(3)25)23(17-18(2)24(4)5,20-13-9-7-10-14-20)21-15-11-8-12-16-21/h7-16,18,22H,6,17H2,1-5H3
IUPAC Name
6-(dimethylamino)-4,4-diphenylheptan-3-yl acetate
SMILES
CCC(OC(C)=O)C(CC(C)N(C)C)(C1=CC=CC=C1)C1=CC=CC=C1
Pharmacology
IndicationUsed mainly in the treatment of narcotic dependence.
Structured Indications Not Available
PharmacodynamicsMethadyl Acetate is a narcotic analgesic with a long onset and duration of action. The drug decreases a patients opioid use by preventing opioid withdrawal and in how it can mimic some of the effects of opioids.
Mechanism of actionMethadyl Acetate is primarily a mu-type opioid receptor agonist. It functions similarily to methadone.
TargetKindPharmacological actionActionsOrganismUniProt ID
Mu-type opioid receptorProteinyes
agonist
HumanP35372 details
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityNot Available
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Methadyl Acetate Action PathwayDrug actionSMP00678
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
1,1,1,2 TetrafluoroethaneThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with 1,1,1,2 Tetrafluoroethane.Investigational
2,5-Dimethoxy-4-ethylamphetamine2,5-Dimethoxy-4-ethylamphetamine may increase the analgesic activities of Methadyl Acetate.Experimental, Illicit
3,4-Methylenedioxyamphetamine3,4-Methylenedioxyamphetamine may increase the analgesic activities of Methadyl Acetate.Experimental, Illicit
3,4-Methylenedioxymethamphetamine3,4-Methylenedioxymethamphetamine may increase the analgesic activities of Methadyl Acetate.Experimental, Illicit
4-Bromo-2,5-dimethoxyamphetamine4-Bromo-2,5-dimethoxyamphetamine may increase the analgesic activities of Methadyl Acetate.Experimental, Illicit
7-NitroindazoleThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with 7-Nitroindazole.Experimental
AcepromazineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Acepromazine.Approved, Vet Approved
AceprometazineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Aceprometazine.Approved
AcetazolamideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Acetazolamide.Approved, Vet Approved
AclidiniumThe risk or severity of adverse effects can be increased when Aclidinium is combined with Methadyl Acetate.Approved
adipiplonThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with adipiplon.Investigational
AgomelatineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Agomelatine.Approved, Investigational
AlfaxaloneThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Alfaxalone.Vet Approved
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Methadyl Acetate.Approved, Illicit
AlimemazineAlimemazine may increase the hypotensive activities of Methadyl Acetate.Approved, Vet Approved
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Alphacetylmethadol.Experimental, Illicit
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Methadyl Acetate.Approved, Illicit, Investigational
AlvimopanThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Alvimopan.Approved
AmilorideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Amiloride.Approved
AmisulprideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Amisulpride.Approved, Investigational
AmitriptylineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Amitriptyline.Approved
Ammonium chlorideAmmonium chloride may increase the excretion rate of Methadyl Acetate which could result in a lower serum level and potentially a reduction in efficacy.Approved, Vet Approved
AmobarbitalThe risk or severity of adverse effects can be increased when Amobarbital is combined with Methadyl Acetate.Approved, Illicit
AmoxapineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Amoxapine.Approved
AmperozideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Amperozide.Experimental
AmphetamineAmphetamine may increase the analgesic activities of Methadyl Acetate.Approved, Illicit
Anisotropine MethylbromideThe risk or severity of adverse effects can be increased when Anisotropine Methylbromide is combined with Methadyl Acetate.Approved
AripiprazoleThe risk or severity of adverse effects can be increased when Aripiprazole is combined with Methadyl Acetate.Approved, Investigational
ArticaineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Articaine.Approved
AsenapineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Asenapine.Approved
Atracurium besylateThe risk or severity of adverse effects can be increased when Atracurium besylate is combined with Methadyl Acetate.Approved
AtropineThe risk or severity of adverse effects can be increased when Atropine is combined with Methadyl Acetate.Approved, Vet Approved
AzaperoneThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Azaperone.Vet Approved
AzelastineMethadyl Acetate may increase the central nervous system depressant (CNS depressant) activities of Azelastine.Approved
AzelastineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Azelastine.Approved
AzosemideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Azosemide.Investigational
BaclofenThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Baclofen.Approved
BarbitalThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Barbital.Illicit
BenactyzineThe risk or severity of adverse effects can be increased when Benactyzine is combined with Methadyl Acetate.Withdrawn
BendroflumethiazideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Bendroflumethiazide.Approved
BenperidolThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Benperidol.Investigational
BenzatropineThe risk or severity of adverse effects can be increased when Benzatropine is combined with Methadyl Acetate.Approved
BenzocaineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Methadyl Acetate.Approved
BenzphetamineBenzphetamine may increase the analgesic activities of Methadyl Acetate.Approved, Illicit
Benzyl alcoholThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Benzyl alcohol.Approved
BiperidenThe risk or severity of adverse effects can be increased when Biperiden is combined with Methadyl Acetate.Approved
BL-1020BL-1020 may increase the hypotensive activities of Methadyl Acetate.Investigational
BrexpiprazoleThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Brexpiprazole.Approved
BrimonidineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Brimonidine.Approved
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Methadyl Acetate.Approved
BromazepamThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Bromazepam.Approved, Illicit
BrompheniramineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Brompheniramine.Approved
BrotizolamThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Brotizolam.Approved, Withdrawn
BumetanideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Bumetanide.Approved
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Methadyl Acetate.Approved, Investigational
BuprenorphineMethadyl Acetate may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Methadyl Acetate.Approved, Investigational
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Methadyl Acetate.Approved, Illicit
ButacaineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Butacaine.Vet Approved
ButalbitalThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Butalbital.Approved, Illicit
ButambenThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Butamben.Approved
ButethalThe risk or severity of adverse effects can be increased when Butethal is combined with Methadyl Acetate.Approved, Illicit
ButorphanolButorphanol may decrease the analgesic activities of Methadyl Acetate.Approved, Illicit, Vet Approved
Canrenoic acidThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Canrenoic acid.Approved, Withdrawn
CanrenoneThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Canrenone.Investigational
CarbamazepineThe risk or severity of adverse effects can be increased when Carbamazepine is combined with Methadyl Acetate.Approved, Investigational
CarbinoxamineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Carbinoxamine.Approved
CarfentanilThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Carfentanil.Illicit, Vet Approved
CarisoprodolThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Carisoprodol.Approved
CetirizineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Cetirizine.Approved
Chloral hydrateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Chloral hydrate.Approved, Illicit, Vet Approved
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Methadyl Acetate.Approved, Illicit
ChlormezanoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Methadyl Acetate.Approved, Withdrawn
ChloroprocaineThe risk or severity of adverse effects can be increased when Chloroprocaine is combined with Methadyl Acetate.Approved
ChlorothiazideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Chlorothiazide.Approved, Vet Approved
ChlorphenamineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Chlorphenamine.Approved
ChlorphenoxamineThe risk or severity of adverse effects can be increased when Chlorphenoxamine is combined with Methadyl Acetate.Withdrawn
ChlorphentermineChlorphentermine may increase the analgesic activities of Methadyl Acetate.Illicit, Withdrawn
ChlorpromazineThe risk or severity of adverse effects can be increased when Chlorpromazine is combined with Methadyl Acetate.Approved, Vet Approved
ChlorprothixeneThe risk or severity of adverse effects can be increased when Chlorprothixene is combined with Methadyl Acetate.Approved, Withdrawn
ChlorthalidoneThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Chlorthalidone.Approved
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Chlorzoxazone.Approved
CicletanineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Cicletanine.Investigational
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Methadyl Acetate.Approved, Vet Approved
CitalopramMethadyl Acetate may increase the serotonergic activities of Citalopram.Approved
ClemastineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Clemastine.Approved
ClidiniumThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Clidinium.Approved
ClobazamThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Clobazam.Approved, Illicit
clomethiazoleThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with clomethiazole.Investigational
ClomipramineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Clomipramine.Approved, Vet Approved
ClonazepamThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Clonazepam.Approved, Illicit
ClonidineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Clonidine.Approved
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Methadyl Acetate.Approved, Illicit
ClozapineThe risk or severity of adverse effects can be increased when Clozapine is combined with Methadyl Acetate.Approved
CocaineThe risk or severity of adverse effects can be increased when Cocaine is combined with Methadyl Acetate.Approved, Illicit
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Methadyl Acetate.Approved, Illicit
ConivaptanThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Conivaptan.Approved, Investigational
CyclizineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Cyclizine.Approved
CyclobenzaprineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Methadyl Acetate.Approved
CyclopentolateThe risk or severity of adverse effects can be increased when Cyclopentolate is combined with Methadyl Acetate.Approved
CyclothiazideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Cyclothiazide.Approved
CyproheptadineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Cyproheptadine.Approved
DantroleneThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Dantrolene.Approved
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Methadyl Acetate.Approved
DapoxetineMethadyl Acetate may increase the serotonergic activities of Dapoxetine.Investigational
DarifenacinThe risk or severity of adverse effects can be increased when Darifenacin is combined with Methadyl Acetate.Approved, Investigational
deramciclaneThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with deramciclane.Investigational
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Methadyl Acetate.Approved
DesipramineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Desipramine.Approved
DesloratadineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Desloratadine.Approved, Investigational
DesmopressinThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Desmopressin.Approved
DesvenlafaxineMethadyl Acetate may increase the serotonergic activities of Desvenlafaxine.Approved
DetomidineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Detomidine.Vet Approved
DexbrompheniramineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Dexbrompheniramine.Approved
DexetimideThe risk or severity of adverse effects can be increased when Dexetimide is combined with Methadyl Acetate.Withdrawn
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Methadyl Acetate.Approved, Vet Approved
DextroamphetamineDextroamphetamine may increase the analgesic activities of Methadyl Acetate.Approved, Illicit
DextromoramideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Dextromoramide.Experimental, Illicit
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Methadyl Acetate.Approved, Illicit, Withdrawn
DezocineThe risk or severity of adverse effects can be increased when Dezocine is combined with Methadyl Acetate.Approved
DiazepamThe risk or severity of adverse effects can be increased when Diazepam is combined with Methadyl Acetate.Approved, Illicit, Vet Approved
DicyclomineThe risk or severity of adverse effects can be increased when Dicyclomine is combined with Methadyl Acetate.Approved
DiethylpropionDiethylpropion may increase the analgesic activities of Methadyl Acetate.Approved, Illicit
DifenoxinThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Difenoxin.Approved, Illicit
DihydrocodeineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Dihydrocodeine.Approved, Illicit
DihydroetorphineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Dihydroetorphine.Experimental, Illicit
DihydromorphineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Dihydromorphine.Experimental, Illicit
DimenhydrinateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Dimenhydrinate.Approved
DiphenhydramineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Methadyl Acetate.Approved
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Methadyl Acetate.Approved, Illicit
DoramectinThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Doramectin.Vet Approved
DoxepinThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Doxepin.Approved
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Methadyl Acetate.Approved, Vet Approved
DPDPEThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with DPDPE.Investigational
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Methadyl Acetate.Approved, Illicit
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Methadyl Acetate.Approved, Vet Approved
DrospirenoneThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Drospirenone.Approved
DrotebanolThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Drotebanol.Experimental, Illicit
DuloxetineMethadyl Acetate may increase the serotonergic activities of Duloxetine.Approved
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Methadyl Acetate.Approved
EcgonineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Ecgonine.Experimental, Illicit
ECGONINE METHYL ESTERThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with ECGONINE METHYL ESTER.Experimental
EcopipamThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Ecopipam.Investigational
EfavirenzThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Efavirenz.Approved, Investigational
EfonidipineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Efonidipine.Approved
EluxadolineMethadyl Acetate may increase the constipating activities of Eluxadoline.Approved
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Methadyl Acetate.Approved, Vet Approved
EntacaponeThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Entacapone.Approved, Investigational
EplerenoneThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Eplerenone.Approved
EscitalopramMethadyl Acetate may increase the serotonergic activities of Escitalopram.Approved, Investigational
EstazolamThe risk or severity of adverse effects can be increased when Estazolam is combined with Methadyl Acetate.Approved, Illicit
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Methadyl Acetate.Approved
Etacrynic acidThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Etacrynic acid.Approved
EthanolMethadyl Acetate may increase the central nervous system depressant (CNS depressant) activities of Ethanol.Approved
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Methadyl Acetate.Approved, Illicit, Withdrawn
EthopropazineThe risk or severity of adverse effects can be increased when Ethopropazine is combined with Methadyl Acetate.Approved
EthosuximideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Ethosuximide.Approved
EthotoinThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Ethotoin.Approved
EthoxzolamideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Ethoxzolamide.Withdrawn
Ethyl carbamateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Ethyl carbamate.Withdrawn
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Ethyl loflazepate.Approved, Illicit
EthylmorphineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Ethylmorphine.Approved, Illicit
EtidocaineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Etidocaine.Approved
EtifoxineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Etifoxine.Withdrawn
EtizolamThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Etizolam.Approved
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Methadyl Acetate.Approved
EtoperidoneMethadyl Acetate may increase the serotonergic activities of Etoperidone.Approved
EtorphineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Etorphine.Illicit, Vet Approved
EzogabineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Ezogabine.Approved
FelbamateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Felbamate.Approved
FencamfamineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Fencamfamine.Approved, Illicit, Withdrawn
FentanylThe risk or severity of adverse effects can be increased when Fentanyl is combined with Methadyl Acetate.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe risk or severity of adverse effects can be increased when Fesoterodine is combined with Methadyl Acetate.Approved
FexofenadineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Fexofenadine.Approved
FlibanserinThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Flibanserin.Approved
FludiazepamThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Fludiazepam.Approved, Illicit
FlunarizineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Flunarizine.Approved
FlunitrazepamThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Flunitrazepam.Approved, Illicit
FluoxetineMethadyl Acetate may increase the serotonergic activities of Fluoxetine.Approved, Vet Approved
FlupentixolThe risk or severity of adverse effects can be increased when Flupentixol is combined with Methadyl Acetate.Approved, Withdrawn
FluphenazineThe risk or severity of adverse effects can be increased when Fluphenazine is combined with Methadyl Acetate.Approved
FlurazepamThe risk or severity of adverse effects can be increased when Flurazepam is combined with Methadyl Acetate.Approved, Illicit
FluspirileneThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Fluspirilene.Approved
Fluticasone PropionateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Fluticasone Propionate.Approved
FluvoxamineThe risk or severity of adverse effects can be increased when Fluvoxamine is combined with Methadyl Acetate.Approved, Investigational
FosphenytoinThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Fosphenytoin.Approved
FospropofolThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Fospropofol.Approved, Illicit
FurosemideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Furosemide.Approved, Vet Approved
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Methadyl Acetate.Approved, Investigational
gabapentin enacarbilThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with gabapentin enacarbil.Approved
Gallamine TriethiodideThe risk or severity of adverse effects can be increased when Gallamine Triethiodide is combined with Methadyl Acetate.Approved
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Gamma Hydroxybutyric Acid.Approved, Illicit
GepironeThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Gepirone.Investigational
GlutethimideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Glutethimide.Approved, Illicit
GlycopyrroniumThe risk or severity of adverse effects can be increased when Glycopyrronium is combined with Methadyl Acetate.Approved, Investigational, Vet Approved
GuanfacineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Guanfacine.Approved, Investigational
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with Methadyl Acetate.Approved, Illicit, Withdrawn
HaloperidolThe risk or severity of adverse effects can be increased when Haloperidol is combined with Methadyl Acetate.Approved
HalothaneThe risk or severity of adverse effects can be increased when Halothane is combined with Methadyl Acetate.Approved, Vet Approved
HeroinThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Heroin.Approved, Illicit
HexamethoniumThe risk or severity of adverse effects can be increased when Hexamethonium is combined with Methadyl Acetate.Experimental
HexobarbitalThe risk or severity of adverse effects can be increased when Hexobarbital is combined with Methadyl Acetate.Approved
HomatropineThe risk or severity of adverse effects can be increased when Homatropine is combined with Methadyl Acetate.Approved
HydrochlorothiazideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Hydrochlorothiazide.Approved, Vet Approved
HydrocodoneMethadyl Acetate may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.Approved, Illicit
HydroflumethiazideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Hydroflumethiazide.Approved
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Methadyl Acetate.Approved, Illicit
Hydroxyamphetamine hydrobromideHydroxyamphetamine hydrobromide may increase the analgesic activities of Methadyl Acetate.Approved
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Methadyl Acetate.Approved
HyoscyamineThe risk or severity of adverse effects can be increased when Hyoscyamine is combined with Methadyl Acetate.Approved
IloperidoneThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Iloperidone.Approved
ImipramineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Imipramine.Approved
IndalpineMethadyl Acetate may increase the serotonergic activities of Indalpine.Investigational, Withdrawn
IndapamideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Indapamide.Approved
Ipratropium bromideThe risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Methadyl Acetate.Approved
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Methadyl Acetate.Approved, Vet Approved
IsosorbideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Isosorbide.Approved
KetamineThe risk or severity of adverse effects can be increased when Ketamine is combined with Methadyl Acetate.Approved, Vet Approved
KetazolamThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Ketazolam.Approved
KetobemidoneThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Ketobemidone.Approved
KW-3902The risk or severity of adverse effects can be increased when Methadyl Acetate is combined with KW-3902.Investigational
LamotrigineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Lamotrigine.Approved, Investigational
LevetiracetamThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Levetiracetam.Approved, Investigational
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Methadyl Acetate.Approved
LevocabastineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Levocabastine.Approved
LevocetirizineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Levocetirizine.Approved
LevodopaThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Levodopa.Approved
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Methadyl Acetate.Approved
LevomilnacipranMethadyl Acetate may increase the serotonergic activities of Levomilnacipran.Approved
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Methadyl Acetate.Approved
LidocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Methadyl Acetate.Approved, Vet Approved
LisdexamfetamineLisdexamfetamine may increase the analgesic activities of Methadyl Acetate.Approved, Investigational
LithiumThe risk or severity of adverse effects can be increased when Lithium is combined with Methadyl Acetate.Approved
LofentanilThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Lofentanil.Illicit
LoratadineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Loratadine.Approved
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Methadyl Acetate.Approved
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Methadyl Acetate.Approved
Lu AA21004The risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Lu AA21004.Investigational
LurasidoneThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Lurasidone.Approved
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Methadyl Acetate.Approved, Vet Approved
MannitolThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Mannitol.Approved, Investigational
MaprotilineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Maprotiline.Approved
MecamylamineThe risk or severity of adverse effects can be increased when Mecamylamine is combined with Methadyl Acetate.Approved
MeclizineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Meclizine.Approved
MedetomidineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Medetomidine.Vet Approved
MelatoninThe risk or severity of adverse effects can be increased when Melatonin is combined with Methadyl Acetate.Approved, Nutraceutical, Vet Approved
MelperoneThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Melperone.Approved
MephedroneMephedrone may increase the analgesic activities of Methadyl Acetate.Investigational
MephentermineMephentermine may increase the analgesic activities of Methadyl Acetate.Approved
MepivacaineThe risk or severity of adverse effects can be increased when Mepivacaine is combined with Methadyl Acetate.Approved, Vet Approved
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Methadyl Acetate.Approved, Illicit
MersalylThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Mersalyl.Approved
MesoridazineThe risk or severity of adverse effects can be increased when Mesoridazine is combined with Methadyl Acetate.Approved
MetaxaloneThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Metaxalone.Approved
MethadoneThe risk or severity of adverse effects can be increased when Methadone is combined with Methadyl Acetate.Approved
MethamphetamineMethamphetamine may increase the analgesic activities of Methadyl Acetate.Approved, Illicit
MethanthelineThe risk or severity of adverse effects can be increased when Methantheline is combined with Methadyl Acetate.Approved
MethapyrileneThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Methapyrilene.Withdrawn
MethaqualoneThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Methaqualone.Illicit, Withdrawn
MethazolamideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Methazolamide.Approved
MethocarbamolThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Methocarbamol.Approved, Vet Approved
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Methadyl Acetate.Approved
MethotrimeprazineMethadyl Acetate may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.Approved
MethoxyfluraneThe risk or severity of adverse effects can be increased when Methoxyflurane is combined with Methadyl Acetate.Approved, Vet Approved
MethsuximideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Methsuximide.Approved
MethyclothiazideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Methyclothiazide.Approved
Methylene blueMethylene blue may increase the hypotensive activities of Methadyl Acetate.Investigational
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Methadyl Acetate.Approved
MetixeneThe risk or severity of adverse effects can be increased when Metixene is combined with Methadyl Acetate.Approved
MetolazoneThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Metolazone.Approved
MetyrosineMethadyl Acetate may increase the sedative activities of Metyrosine.Approved
MidazolamThe risk or severity of adverse effects can be increased when Midazolam is combined with Methadyl Acetate.Approved, Illicit
MilnacipranMethadyl Acetate may increase the serotonergic activities of Milnacipran.Approved
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Methadyl Acetate.Approved, Investigational
MirtazapineMethadyl Acetate may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.Approved
MMDAMMDA may increase the analgesic activities of Methadyl Acetate.Experimental, Illicit
MolindoneThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Molindone.Approved
MoricizineMoricizine may increase the hypotensive activities of Methadyl Acetate.Approved, Withdrawn
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Methadyl Acetate.Approved, Investigational
N-butylscopolammonium bromideThe risk or severity of adverse effects can be increased when N-butylscopolammonium bromide is combined with Methadyl Acetate.Vet Approved
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Methadyl Acetate.Approved, Investigational
NalbuphineNalbuphine may decrease the analgesic activities of Methadyl Acetate.Approved
NaltrexoneThe therapeutic efficacy of Methadyl Acetate can be decreased when used in combination with Naltrexone.Approved, Investigational, Vet Approved
NefazodoneMethadyl Acetate may increase the serotonergic activities of Nefazodone.Approved, Withdrawn
NitrazepamThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Nitrazepam.Approved
Nitrous oxideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Nitrous oxide.Approved, Vet Approved
NormethadoneThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Normethadone.Approved, Illicit
NortriptylineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Nortriptyline.Approved
NVA237The risk or severity of adverse effects can be increased when NVA237 is combined with Methadyl Acetate.Investigational
OlanzapineThe risk or severity of adverse effects can be increased when Olanzapine is combined with Methadyl Acetate.Approved, Investigational
OlopatadineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Olopatadine.Approved
OndansetronThe risk or severity of adverse effects can be increased when Ondansetron is combined with Methadyl Acetate.Approved
OpiumThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Opium.Approved, Illicit
OrphenadrineMethadyl Acetate may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.Approved
OsanetantThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Osanetant.Investigational
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with Methadyl Acetate.Approved
OxetacaineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Oxetacaine.Investigational
OxprenololThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Oxprenolol.Approved
OxybuprocaineThe risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Methadyl Acetate.Approved
OxybutyninThe risk or severity of adverse effects can be increased when Oxybutynin is combined with Methadyl Acetate.Approved, Investigational
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Methadyl Acetate.Approved, Illicit, Investigational
OxymorphoneThe risk or severity of adverse effects can be increased when Oxymorphone is combined with Methadyl Acetate.Approved, Investigational, Vet Approved
OxyphenoniumThe risk or severity of adverse effects can be increased when Oxyphenonium is combined with Methadyl Acetate.Approved
PaliperidoneThe risk or severity of adverse effects can be increased when Paliperidone is combined with Methadyl Acetate.Approved
PancuroniumThe risk or severity of adverse effects can be increased when Pancuronium is combined with Methadyl Acetate.Approved
ParaldehydeMethadyl Acetate may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
ParoxetineMethadyl Acetate may increase the serotonergic activities of Paroxetine.Approved, Investigational
PegvisomantThe therapeutic efficacy of Pegvisomant can be decreased when used in combination with Methadyl Acetate.Approved
PentazocinePentazocine may decrease the analgesic activities of Methadyl Acetate.Approved, Vet Approved
PentobarbitalThe risk or severity of adverse effects can be increased when Pentobarbital is combined with Methadyl Acetate.Approved, Vet Approved
PentoliniumThe risk or severity of adverse effects can be increased when Pentolinium is combined with Methadyl Acetate.Approved
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Methadyl Acetate.Approved
PerazineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Perazine.Investigational
PerospironeThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Perospirone.Approved
PerphenazineThe risk or severity of adverse effects can be increased when Perphenazine is combined with Methadyl Acetate.Approved
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Methadyl Acetate.Approved
PhenobarbitalThe risk or severity of adverse effects can be increased when Phenobarbital is combined with Methadyl Acetate.Approved
PhenoxyethanolThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Phenoxyethanol.Approved
PhenterminePhentermine may increase the analgesic activities of Methadyl Acetate.Approved, Illicit
PhenytoinThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Phenytoin.Approved, Vet Approved
PimozideThe risk or severity of adverse effects can be increased when Pimozide is combined with Methadyl Acetate.Approved
PipamperoneThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Pipamperone.Approved
PipecuroniumThe risk or severity of adverse effects can be increased when Pipecuronium is combined with Methadyl Acetate.Approved
PipotiazineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Pipotiazine.Approved
PirenzepineThe risk or severity of adverse effects can be increased when Pirenzepine is combined with Methadyl Acetate.Approved
PiretanideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Piretanide.Experimental
PiritramideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Piritramide.Investigational
PizotifenThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Pizotifen.Approved
PolythiazideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Polythiazide.Approved
PomalidomideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Pomalidomide.Approved
PotassiumThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Potassium.Approved
Potassium CitrateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Potassium Citrate.Approved, Vet Approved
PramipexoleMethadyl Acetate may increase the sedative activities of Pramipexole.Approved, Investigational
PramocaineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Pramocaine.Approved
PrazepamThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Prazepam.Approved, Illicit
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Methadyl Acetate.Approved, Illicit, Investigational
PregnanoloneThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Pregnanolone.Investigational
PrilocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Methadyl Acetate.Approved
PrimidoneThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Primidone.Approved, Vet Approved
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with Methadyl Acetate.Approved, Investigational, Vet Approved
ProchlorperazineThe risk or severity of adverse effects can be increased when Prochlorperazine is combined with Methadyl Acetate.Approved, Vet Approved
ProcyclidineThe risk or severity of adverse effects can be increased when Procyclidine is combined with Methadyl Acetate.Approved
PromazineThe risk or severity of adverse effects can be increased when Promazine is combined with Methadyl Acetate.Approved, Vet Approved
PromethazineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Promethazine.Approved
PropanthelineThe risk or severity of adverse effects can be increased when Propantheline is combined with Methadyl Acetate.Approved
ProparacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Methadyl Acetate.Approved, Vet Approved
PropiopromazinePropiopromazine may increase the hypotensive activities of Methadyl Acetate.Vet Approved
PropiverineThe risk or severity of adverse effects can be increased when Propiverine is combined with Methadyl Acetate.Investigational
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Methadyl Acetate.Approved, Investigational, Vet Approved
PropoxycaineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Propoxycaine.Approved
ProtriptylineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Protriptyline.Approved
PSD502The risk or severity of adverse effects can be increased when Methadyl Acetate is combined with PSD502.Investigational
PseudoephedrinePseudoephedrine may increase the analgesic activities of Methadyl Acetate.Approved
QuazepamThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Quazepam.Approved, Illicit
QuetiapineThe risk or severity of adverse effects can be increased when Quetiapine is combined with Methadyl Acetate.Approved
QuinethazoneThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Quinethazone.Approved
QuinidineThe risk or severity of adverse effects can be increased when Quinidine is combined with Methadyl Acetate.Approved
RacloprideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Raclopride.Investigational
RamelteonThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Ramelteon.Approved, Investigational
RamosetronMethadyl Acetate may increase the constipating activities of Ramosetron.Approved
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Methadyl Acetate.Approved
RemoxiprideThe risk or severity of adverse effects can be increased when Remoxipride is combined with Methadyl Acetate.Approved, Withdrawn
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Methadyl Acetate.Approved
RisperidoneThe risk or severity of adverse effects can be increased when Risperidone is combined with Methadyl Acetate.Approved, Investigational
RitanserinThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Ritanserin.Investigational
RitobegronRitobegron may increase the analgesic activities of Methadyl Acetate.Investigational
RolofyllineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Rolofylline.Investigational
RomifidineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Romifidine.Vet Approved
RopiniroleMethadyl Acetate may increase the sedative activities of Ropinirole.Approved, Investigational
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Methadyl Acetate.Approved
RotigotineMethadyl Acetate may increase the sedative activities of Rotigotine.Approved
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Methadyl Acetate.Approved
S-EthylisothioureaThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with S-Ethylisothiourea.Experimental
Sage 547The risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Sage 547.Investigational
ScopolamineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Scopolamine.Approved
Scopolamine butylbromideThe risk or severity of adverse effects can be increased when Scopolamine butylbromide is combined with Methadyl Acetate.Approved
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Methadyl Acetate.Approved, Vet Approved
SertindoleThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Sertindole.Approved, Withdrawn
SertralineMethadyl Acetate may increase the serotonergic activities of Sertraline.Approved
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Methadyl Acetate.Approved, Vet Approved
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Methadyl Acetate.Approved
SolifenacinThe risk or severity of adverse effects can be increased when Solifenacin is combined with Methadyl Acetate.Approved
SpironolactoneThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Spironolactone.Approved
StiripentolThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Stiripentol.Approved
SuccinylcholineSuccinylcholine may increase the bradycardic activities of Methadyl Acetate.Approved
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Methadyl Acetate.Approved, Investigational
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Methadyl Acetate.Approved
SuvorexantMethadyl Acetate may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.Approved
TandospironeThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Tandospirone.Investigational
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Methadyl Acetate.Approved
TasimelteonThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Tasimelteon.Approved
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Methadyl Acetate.Approved
TetrabenazineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Tetrabenazine.Approved
TetracaineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Tetracaine.Approved, Vet Approved
TetrodotoxinThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Tetrodotoxin.Investigational
ThalidomideMethadyl Acetate may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.Approved, Investigational, Withdrawn
TheobromineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Theobromine.Approved
ThiamylalThe risk or severity of adverse effects can be increased when Thiamylal is combined with Methadyl Acetate.Approved, Vet Approved
ThiethylperazineThiethylperazine may increase the hypotensive activities of Methadyl Acetate.Withdrawn
ThiopentalThe risk or severity of adverse effects can be increased when Thiopental is combined with Methadyl Acetate.Approved, Vet Approved
ThioridazineThe risk or severity of adverse effects can be increased when Thioridazine is combined with Methadyl Acetate.Approved
ThiothixeneThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Thiothixene.Approved
TiagabineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Tiagabine.Approved
TiaprideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Tiapride.Investigational
TicrynafenThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Ticrynafen.Withdrawn
TiletamineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Tiletamine.Vet Approved
TiotropiumThe risk or severity of adverse effects can be increased when Tiotropium is combined with Methadyl Acetate.Approved
TizanidineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Tizanidine.Approved
TolcaponeThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Tolcapone.Approved, Withdrawn
TolterodineThe risk or severity of adverse effects can be increased when Tolterodine is combined with Methadyl Acetate.Approved, Investigational
TolvaptanThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Tolvaptan.Approved
TopiramateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Topiramate.Approved
TorasemideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Torasemide.Approved
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Methadyl Acetate.Approved, Investigational
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Trans-2-Phenylcyclopropylamine.Experimental
TranylcypromineThe risk or severity of adverse effects can be increased when Tranylcypromine is combined with Methadyl Acetate.Approved
TrazodoneThe risk or severity of adverse effects can be increased when Trazodone is combined with Methadyl Acetate.Approved, Investigational
TriamtereneThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Triamterene.Approved
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with Methadyl Acetate.Approved
TrichlormethiazideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Trichlormethiazide.Approved, Vet Approved
TrifluoperazineThe risk or severity of adverse effects can be increased when Trifluoperazine is combined with Methadyl Acetate.Approved
TriflupromazineThe risk or severity of adverse effects can be increased when Triflupromazine is combined with Methadyl Acetate.Approved, Vet Approved
TrihexyphenidylThe risk or severity of adverse effects can be increased when Trihexyphenidyl is combined with Methadyl Acetate.Approved
TrimethaphanThe risk or severity of adverse effects can be increased when Trimethaphan is combined with Methadyl Acetate.Approved
TrimipramineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Trimipramine.Approved
TriprolidineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Triprolidine.Approved
TropicamideThe risk or severity of adverse effects can be increased when Tropicamide is combined with Methadyl Acetate.Approved
TrospiumThe risk or severity of adverse effects can be increased when Trospium is combined with Methadyl Acetate.Approved
TubocurarineThe risk or severity of adverse effects can be increased when Tubocurarine is combined with Methadyl Acetate.Approved
Uc1010The risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Uc1010.Investigational
UlaritideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Ularitide.Investigational
UmeclidiniumThe risk or severity of adverse effects can be increased when Umeclidinium is combined with Methadyl Acetate.Approved
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Methadyl Acetate.Approved, Investigational
VecuroniumThe risk or severity of adverse effects can be increased when Vecuronium is combined with Methadyl Acetate.Approved
VenlafaxineMethadyl Acetate may increase the serotonergic activities of Venlafaxine.Approved
VigabatrinThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Vigabatrin.Approved
VortioxetineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Vortioxetine.Approved
XylazineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Xylazine.Vet Approved
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with Methadyl Acetate.Approved, Illicit, Investigational
ZiconotideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Ziconotide.Approved
ZimelidineMethadyl Acetate may increase the serotonergic activities of Zimelidine.Withdrawn
ZiprasidoneThe risk or severity of adverse effects can be increased when Ziprasidone is combined with Methadyl Acetate.Approved
ZolazepamThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Zolazepam.Vet Approved
ZolpidemMethadyl Acetate may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.Approved
ZonisamideThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Zonisamide.Approved, Investigational
ZopicloneThe risk or severity of adverse effects can be increased when Zopiclone is combined with Methadyl Acetate.Approved
ZotepineThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Zotepine.Approved
ZuclopenthixolThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Zuclopenthixol.Approved, Investigational
Food InteractionsNot Available
References
Synthesis ReferenceNot Available
General ReferencesNot Available
External Links
ATC CodesNot Available
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelNot Available
MSDSNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9965
Blood Brain Barrier+0.9648
Caco-2 permeable+0.7459
P-glycoprotein substrateSubstrate0.5822
P-glycoprotein inhibitor IInhibitor0.8472
P-glycoprotein inhibitor IINon-inhibitor0.8897
Renal organic cation transporterNon-inhibitor0.6473
CYP450 2C9 substrateNon-substrate0.7976
CYP450 2D6 substrateNon-substrate0.8641
CYP450 3A4 substrateSubstrate0.6658
CYP450 1A2 substrateInhibitor0.5619
CYP450 2C9 inhibitorNon-inhibitor0.8153
CYP450 2D6 inhibitorInhibitor0.7123
CYP450 2C19 inhibitorNon-inhibitor0.7312
CYP450 3A4 inhibitorInhibitor0.5242
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.5811
Ames testNon AMES toxic0.9016
CarcinogenicityCarcinogens 0.7025
BiodegradationNot ready biodegradable0.9792
Rat acute toxicity3.3406 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9706
hERG inhibition (predictor II)Inhibitor0.7157
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage formsNot Available
PricesNot Available
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
logP4.27HANSCH,C ET AL. (1995)
Predicted Properties
PropertyValueSource
Water Solubility0.00179 mg/mLALOGPS
logP4.78ALOGPS
logP4.88ChemAxon
logS-5.3ALOGPS
pKa (Strongest Basic)9.87ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area29.54 Å2ChemAxon
Rotatable Bond Count9ChemAxon
Refractivity117.86 m3·mol-1ChemAxon
Polarizability40.82 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
Taxonomy
ClassificationNot classified

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Voltage-gated calcium channel activity
Specific Function:
Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociati...
Gene Name:
OPRM1
Uniprot ID:
P35372
Molecular Weight:
44778.855 Da
References
  1. Mancino MJ, McGaugh J, Feldman Z, Poling J, Oliveto A: Effect of PTSD diagnosis and contingency management procedures on cocaine use in dually cocaine- and opioid-dependent individuals maintained on LAAM: a retrospective analysis. Am J Addict. 2010 Mar-Apr;19(2):169-77. doi: 10.1111/j.1521-0391.2009.00025.x. [PubMed:20163389 ]
  2. Walczak SA, Makman MH, Gardner EL: Acetylmethadol metabolites influence opiate receptors and adenylate cyclase in amygdala. Eur J Pharmacol. 1981 Jul 10;72(4):343-9. [PubMed:6268422 ]
  3. Wolstein J, Gastpar M, Finkbeiner T, Heinrich C, Heitkamp R, Poehlke T, Scherbaum N: A randomized, open-label trial comparing methadone and Levo-Alpha-Acetylmethadol (LAAM) in maintenance treatment of opioid addiction. Pharmacopsychiatry. 2009 Jan;42(1):1-8. doi: 10.1055/s-0028-1083818. Epub 2009 Jan 19. [PubMed:19153939 ]
  4. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
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Drug created on July 24, 2007 14:16 / Updated on August 17, 2016 12:23