Name
Opioids
Accession Number
DBCAT000480
Description

Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS.

ATC Classification
Drugs
DrugDrug Description
TramadolA centrally-acting opioid agonist and SNRI (serotonin/norepinephrine reuptake inhibitor) used for the management of moderate to severe pain in adults.
MorphineAn opioid agonist used for the relief of moderate to severe acute and chronic pain.
HydromorphoneAn opioid analgesic used to treat moderate to severe pain when the use of an opioid is indicated.
MethadoneAn opioid analgesic indicated for management of severe pain that is not responsive to alternative treatments. Also used to aid in detoxification and maintenance treatment of opioid addiction.
MeperidineAn opioid agonist with analgesic and sedative properties used to manage severe pain.
OxycodoneAn opioid used in the management of moderate to severe pain.
ButorphanolAn opioid agonist-antagonist used to treat moderate to severe pain.
DextropropoxypheneAn opioid analgesic used to treat mild to moderate pain.
PentazocineAn analgesic used to treat moderate to severe pain.
FentanylAn opioid analgesic used in anesthesia, for breakthrough cancer pain, or round the clock pain management.
NalbuphineAn opioid agonist-antagonist used to treat pain, for pre and postoperative analgesia, and for analgesia in labor and delivery.
BuprenorphineA partial opioid agonist used for management of severe pain that is not responsive to alternative treatments. Also used for maintenance treatment of opioid addiction.
DezocineIndicated in the treatment of moderate to severe pain.
DextromoramideAn opioid analgesic structurally related to methadone and used in the treatment of severe pain. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1070)
DihydrocodeineAn opioid analgesic agent used for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate.
KetobemidoneFor the treatment of all types of severe pain, such as postoperative, cancer, kidney stones and fractures.
PiritramidePiritramide is under investigation for the treatment of Colon Cancer and Minimal Residual Disease. Piritramide has been investigated for the supportive care of Pain, Postoperative and Postoperative Nausea and Vomiting.
MeptazinolNot Annotated
PhenazocineNot Annotated
TilidineNot Annotated
CodeineAn opioid analgesic used to treat moderate to severe pain when the use of an opioid is indicated.
SufentanilAn opioid used to induce and maintain anesthesia, to act as an analgesic in labor and delivery, and to treat severe, acute pain.
AlfentanilAn opioid agonist used to induce and maintain anesthesia, as well as an analgesic.
LevorphanolAn opioid analgesic used to treat moderate to severe pain.
RemifentanilAn opioid analgesic used in anesthesia.
HydrocodoneAn opioid agonist used as an analgesic and antitussive agent.
DiphenoxylateAn antidiarrheal medication used with atropine to manage diarrhea.
OxymorphoneAn opioid analgesic used in the management of moderate-to-severe pain and for analgesic therapies.
LevacetylmethadolFor the treatment and management of opiate dependence. It is sometimes used to treat severe pain in terminal patients.
Methadyl acetateUsed mainly in the treatment of narcotic dependence.
DihydroetorphineNot Available
DiamorphineAn opioid analgesic agent used in the relief of severe pain associated with surgical procedures, myocardial infarction or pain in the terminally ill and for the relief of dyspnea in acute pulmonary edema.
EthylmorphineEthylmorphine is an analgesic used for pain relief.
EtorphineEtorphine is only available for its use in veterinary. This main usage is related to the immobilization of large mammals.
CarfentanilCarfentanil is similar (but more potent) to the opioid analgesic fentanyl. It is used as a tranquilizer for large animals.
AlphacetylmethadolA narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence. [PubChem]
DihydromorphineDihydromorphine is an opioid analgesic used for moderate to severe pain relief.
DPDPEA heterodetic cyclic peptide that is a cyclic enkephalin analogue, having D-penicillaminyl residues located at positions 2 and 5, which form the heterocycle via a disulfide bond.
LofentanilLofentanil is an analog of fentanyl and is one of the most potent opioids available today. It displays most similarity to carfentanil (4-carbomethoxyfentanyl) and is considered to be slightly more...
OpiumA medication used to treat moderate to severe pain.
NormethadoneAn opioid antitussive used to treat a cough associated with inflamed mucosa.
AlphaprodineNot Annotated
PhenoperidineNot Annotated
BezitramideA narcotic analgesic once used for the treatment of severe chronic pain.
TapentadolAn opioid used to manage severe pain that has not responded to non-opioid medications, and for which opioid analgesic therapy is appropriate.
NicomorphineNot Annotated
NaltrexoneA narcotic antagonist used in opioid overdose.
EluxadolineA mixed mu-opioid receptor agonist used to treat irritable bowel syndrome with diarrhea.
Carfentanil, C-11Carfentanil, C-11 is under investigation in clinical trial NCT01899170 (Towards Individualized Deep Brain Stimulation Treatment of Chronic Neuropathic Pain).
DesomorphineNot Available
BenzhydrocodoneBenzyhydrocodone is indicated, in combination with acetaminophen, for the short-term management of acute pain requiring opioid therapy.
Drugs & Drug Targets
DrugTargetType
TramadolMu-type opioid receptortarget
TramadolSodium-dependent noradrenaline transportertarget
Tramadol5-hydroxytryptamine receptor 2Ctarget
TramadolKappa-type opioid receptortarget
TramadolSodium-dependent serotonin transportertarget
TramadolCytochrome P450 2D6enzyme
TramadolDelta-type opioid receptortarget
TramadolCytochrome P450 3A4enzyme
TramadolCytochrome P450 2B6enzyme
TramadolAlpha-7 nicotinic cholinergic receptor subunittarget
TramadolMuscarinic acetylcholine receptor M3target
TramadolMuscarinic acetylcholine receptor M1target
TramadolUDP-glucuronosyltransferase 1-1enzyme
TramadolNeurokinin 1 receptortarget
TramadolSodium channel protein type 2 subunit alphatarget
TramadolTransient receptor potential cation channel subfamily V member 1target
TramadolNMDA receptortarget
TramadolAdenosine receptor A1target
TramadolAlpha-2 adrenergic receptorstarget
MorphineMu-type opioid receptortarget
MorphineDelta-type opioid receptortarget
MorphineKappa-type opioid receptortarget
MorphineP-glycoprotein 1transporter
MorphineCytochrome P450 2C8enzyme
MorphineCytochrome P450 3A4enzyme
MorphineUDP-glucuronosyltransferase 2B7enzyme
MorphineUDP-glucuronosyltransferase 1-1enzyme
MorphineUDP-glucuronosyltransferase 1-8enzyme
MorphineUDP-glucuronosyltransferase 2B15enzyme
MorphineUDP-glucuronosyltransferase 2B4enzyme
MorphineUDP-glucuronosyltransferase 1-3enzyme
MorphineLymphocyte antigen 96target
MorphineSerum albumincarrier
HydromorphoneMu-type opioid receptortarget
HydromorphoneDelta-type opioid receptortarget
HydromorphoneKappa-type opioid receptortarget
HydromorphoneCytochrome P450 2C9enzyme
HydromorphoneUDP-glucuronosyltransferase 1-3enzyme
HydromorphoneUDP-glucuronosyltransferase 2B7enzyme
HydromorphoneSerum albumincarrier
MethadoneNMDA receptortarget
MethadoneMu-type opioid receptortarget
MethadoneCytochrome P450 2B6enzyme
MethadoneCytochrome P450 3A4enzyme
MethadoneCytochrome P450 2C19enzyme
MethadoneDelta-type opioid receptortarget
MethadoneCytochrome P450 3A7enzyme
MethadoneCytochrome P450 2D6enzyme
MethadoneP-glycoprotein 1transporter
MethadoneCytochrome P450 2C8enzyme
MethadoneCytochrome P450 19A1enzyme
MethadoneCytochrome P450 1A2enzyme
MethadoneCytochrome P450 2C18enzyme
MethadoneCytochrome P450 2C9enzyme
Methadone5-hydroxytryptamine receptor 3Atarget
MethadoneAlpha-1-acid glycoprotein 1carrier
MethadoneSerum albumincarrier
MethadoneNeuronal acetylcholine receptor subunit alpha-7target
MethadoneNeuronal acetylcholine receptor subunit alpha-3target
MethadoneNeuronal acetylcholine receptor subunit alpha-4target
MethadoneNeuronal acetylcholine receptor subunit beta-2target
MeperidineKappa-type opioid receptortarget
MeperidineCytochrome P450 2D6enzyme
MeperidineCytochrome P450 2B6enzyme
MeperidineGlutamate receptor ionotropic, NMDA 1target
MeperidineGlutamate receptor ionotropic, NMDA 2Btarget
MeperidineGlutamate receptor ionotropic, NMDA 2Atarget
MeperidineGlutamate receptor ionotropic, NMDA 2Ctarget
MeperidineGlutamate receptor ionotropic, NMDA 2Dtarget
MeperidineCytochrome P450 2C19enzyme
MeperidineCytochrome P450 3A4enzyme
MeperidineSerum albumincarrier
MeperidineAlpha-1-acid glycoprotein 1carrier
MeperidineMuscarinic acetylcholine receptortarget
MeperidineMu-type opioid receptortarget
MeperidineSodium-dependent dopamine transportertarget
MeperidineSodium-dependent noradrenaline transportertarget
MeperidineSodium-dependent serotonin transportertarget
MeperidineLiver carboxylesterase 1target
MeperidineCytochrome P450 1A2enzyme
MeperidineP-glycoprotein 1transporter
OxycodoneMu-type opioid receptortarget
OxycodoneKappa-type opioid receptortarget
OxycodoneDelta-type opioid receptortarget
OxycodoneCytochrome P450 2D6enzyme
OxycodoneCytochrome P450 3A4enzyme
OxycodoneCytochrome P450 3A5enzyme
OxycodoneSerum albumincarrier
Oxycodonealpha1-acid glycoproteincarrier
ButorphanolKappa-type opioid receptortarget
ButorphanolMu-type opioid receptortarget
ButorphanolDelta-type opioid receptortarget
DextropropoxypheneMu-type opioid receptortarget
DextropropoxypheneDelta-type opioid receptortarget
DextropropoxypheneKappa-type opioid receptortarget
DextropropoxypheneCytochrome P450 2D6enzyme
DextropropoxypheneCytochrome P450 3A4enzyme
DextropropoxypheneLiver carboxylesterase 1target
PentazocineMu-type opioid receptortarget
PentazocineKappa-type opioid receptortarget
PentazocineSigma non-opioid intracellular receptor 1target
PentazocineP-glycoprotein 1transporter
FentanylMu-type opioid receptortarget
FentanylDelta-type opioid receptortarget
FentanylCytochrome P450 3A4enzyme
FentanylCytochrome P450 3A7enzyme
FentanylP-glycoprotein 1transporter
FentanylKappa-type opioid receptortarget
FentanylP-glycoprotein 1target
FentanylSerum albumincarrier
Fentanylalpha1-acid glycoproteincarrier
NalbuphineKappa-type opioid receptortarget
NalbuphineMu-type opioid receptortarget
NalbuphineDelta-type opioid receptortarget
BuprenorphineKappa-type opioid receptortarget
BuprenorphineMu-type opioid receptortarget
BuprenorphineCytochrome P450 3A4enzyme
BuprenorphineCytochrome P450 2D6enzyme
BuprenorphineP-glycoprotein 1transporter
BuprenorphineATP-binding cassette sub-family G member 2transporter
BuprenorphineCytochrome P450 2C9enzyme
BuprenorphineCytochrome P450 3A5enzyme
BuprenorphineCytochrome P450 2C8enzyme
BuprenorphineCytochrome P450 3A7enzyme
BuprenorphineDelta-type opioid receptortarget
BuprenorphineCytochrome P450 2C18enzyme
BuprenorphineCytochrome P450 2C19enzyme
BuprenorphineNociceptin receptortarget
DezocineMu-type opioid receptortarget
DezocineKappa-type opioid receptortarget
DihydrocodeineCytochrome P450 2D6enzyme
DihydrocodeineCytochrome P450 3A4enzyme
KetobemidoneProstaglandin G/H synthase 1enzyme
KetobemidoneCytochrome P450 2C9enzyme
KetobemidoneCytochrome P450 3A4enzyme
KetobemidoneUDP-glucuronosyltransferase 1-9enzyme
KetobemidoneCytochrome P450 2B6enzyme
KetobemidoneCytochrome P450 2C19enzyme
KetobemidoneCytochrome P450 2C8enzyme
KetobemidoneMu-type opioid receptortarget
KetobemidoneKappa-type opioid receptortarget
KetobemidoneDelta-type opioid receptortarget
KetobemidoneNMDA receptortarget
CodeineMu-type opioid receptortarget
CodeineDelta-type opioid receptortarget
CodeineKappa-type opioid receptortarget
CodeineCytochrome P450 2D6enzyme
CodeineCytochrome P450 3A4enzyme
CodeineSolute carrier family 22 member 1transporter
CodeineUDP-glucuronosyltransferase 2B7enzyme
CodeineUDP-glucuronosyltransferase 2B4enzyme
SufentanilMu-type opioid receptortarget
SufentanilDelta-type opioid receptortarget
SufentanilKappa-type opioid receptortarget
SufentanilCytochrome P450 3A4enzyme
AlfentanilMu-type opioid receptortarget
AlfentanilCytochrome P450 3A4enzyme
AlfentanilCytochrome P450 3A5enzyme
AlfentanilAlpha-1-acid glycoprotein 1carrier
AlfentanilSerum albumincarrier
AlfentanilCytochrome P450 3A7enzyme
AlfentanilP-glycoprotein 1transporter
LevorphanolMu-type opioid receptortarget
LevorphanolDelta-type opioid receptortarget
LevorphanolKappa-type opioid receptortarget
RemifentanilMu-type opioid receptortarget
RemifentanilDelta-type opioid receptortarget
RemifentanilKappa-type opioid receptortarget
HydrocodoneMu-type opioid receptortarget
HydrocodoneDelta-type opioid receptortarget
HydrocodoneCytochrome P450 3A4enzyme
HydrocodoneCytochrome P450 2D6enzyme
HydrocodoneCytochrome P450 2B6enzyme
HydrocodoneCytochrome P450 2C19enzyme
HydrocodoneSigma non-opioid intracellular receptor 1target
DiphenoxylateMu-type opioid receptortarget
DiphenoxylateDelta-type opioid receptortarget
OxymorphoneMu-type opioid receptortarget
OxymorphoneCytochrome P450 2D6enzyme
OxymorphoneDelta-type opioid receptortarget
OxymorphoneCytochrome P450 3A4enzyme
LevacetylmethadolMu-type opioid receptortarget
LevacetylmethadolCytochrome P450 3A4enzyme
LevacetylmethadolNeuronal acetylcholine receptor subunit beta-4target
LevacetylmethadolNeuronal acetylcholine receptor subunit alpha-3target
LevacetylmethadolCytochrome P450 3A5enzyme
LevacetylmethadolCytochrome P450 3A7enzyme
Methadyl acetateMu-type opioid receptortarget
DiamorphineMu-type opioid receptortarget
DiamorphineKappa-type opioid receptortarget
DiamorphineDelta-type opioid receptortarget
DiamorphineLiver carboxylesterase 1target
DiamorphineThyroxine-binding globulincarrier
EthylmorphineCytochrome P450 2D6enzyme
EthylmorphineNADPH--cytochrome P450 reductaseenzyme
EthylmorphineMu-type opioid receptortarget
EthylmorphineCytochrome P450 2B6enzyme
EthylmorphineCytochrome P450 3A4enzyme
EtorphineE3 ubiquitin-protein ligase TRIM13target
EtorphinePro-opiomelanocortintarget
EtorphineMu-type opioid receptortarget
EtorphineDelta-type opioid receptortarget
EtorphineKappa-type opioid receptortarget
EtorphineNociceptin receptortarget
CarfentanilMu-type opioid receptortarget
CarfentanilKappa-type opioid receptortarget
CarfentanilDelta-type opioid receptortarget
DihydromorphineE3 ubiquitin-protein ligase TRIM13target
DihydromorphinePro-opiomelanocortintarget
DihydromorphineMu-type opioid receptortarget
DihydromorphineDelta-type opioid receptortarget
DihydromorphineKappa-type opioid receptortarget
DPDPESolute carrier organic anion transporter family member 1B3transporter
OpiumDelta-type opioid receptortarget
OpiumKappa-type opioid receptortarget
OpiumMu-type opioid receptortarget
OpiumSerum albumincarrier
OpiumBeta-2-microglobulincarrier
OpiumCytochrome P450 2D6enzyme
OpiumCytochrome P450 3A4enzyme
TapentadolMu-type opioid receptortarget
TapentadolKappa-type opioid receptortarget
TapentadolDelta-type opioid receptortarget
TapentadolSodium-dependent noradrenaline transportertarget
Tapentadol5-hydroxytryptamine receptor 3Atarget
TapentadolUDP-glucuronosyltransferase 1-9enzyme
TapentadolUDP-glucuronosyltransferase 2B7enzyme
TapentadolCytochrome P450 2D6enzyme
TapentadolCytochrome P450 2C9enzyme
TapentadolCytochrome P450 2C19enzyme
TapentadolSodium-dependent serotonin transportertarget
NaltrexoneMu-type opioid receptortarget
NaltrexoneKappa-type opioid receptortarget
NaltrexoneDelta-type opioid receptortarget
NaltrexoneHCG20471, isoform CRA_ctarget
NaltrexoneUDP-glucuronosyltransferase 1-1enzyme
EluxadolineMu-type opioid receptortarget
EluxadolineDelta-type opioid receptortarget
EluxadolineKappa-type opioid receptortarget
EluxadolineSolute carrier organic anion transporter family member 1B1transporter
EluxadolineCanalicular multispecific organic anion transporter 1transporter
EluxadolineSolute carrier family 22 member 8transporter